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News Article | May 16, 2017
Site: www.prweb.com

UV Skinz, a leading provider in sun-protective clothing will partake in their 10th Annual Save a Baby's Skin Campaign for the entire month of May. For every order placed, UV Skinz will include a UPF 50+ baby sun shirt to raise awareness about the seriousness of skin cancer and the actionable steps that can be taken to prevent as many babies as possible from ever experiencing the feeling of a sunburn. “A single severe sunburn during the first 15 years of life doubles that child’s risk for developing melanoma later on so it is critical children are adequately protected from the sun at all times,” says UV Skinz Founder and CEO, Rhonda Sparks. UV Skinz was founded after the devastating loss of Rhonda's then husband, and has since fueled her passion to prevent other families from experiencing the same fate her family has. “After losing my 32-year-old husband, Darren, to skin cancer, and being left to raise our three little boys on my own, I was determined to bring products to the market that could help families live sun-safe,” she adds. In addition to promoting the importance of sun protection for young children each May, UV Skinz participates year-round in cultivating personal relationships and dialogue with true Warriors, Angels and Survivors of Melanoma and other skin conditions. Featured here in the 'My Story' series on the company's blog, these personal accounts represent the core of UV Skinz' dedication to their mission of education and awareness. This honest exchange of information told by survivors and their loved ones focuses on fostering awareness through personal stories of hope, loss, triumph and healing. UV Skinz is honored to celebrate these heroes by sharing their heartfelt experiences in order to highlight the need to instill sun-safe habits at a young age that will last a lifetime. To receive a certified UPF 50+ Baby Shirt (size 12-24m), simply place an order on the company’s website during the month of May and a 'My First Skinz' sun shirt will be automatically included with your order, no coupon code necessary! About UV Skinz UV Skinz offers a complete line of infant, children, and adult sun-protective clothing and accessories. In addition to providing high quality sun protective apparel, UV Skinz, Inc. donates to hundreds of skin cancer awareness organizations and education events annually. For more information about the company’s mission, sun safety advice, or to purchase products please visit http://www.uvskinz.com


News Article | May 16, 2017
Site: www.marketwired.com

ALAMEDA, CA--(Marketwired - May 16, 2017) - Verific Design Automation, the recognized leader of SystemVerilog, VHDL and Unified Power Format (UPF) Parser Platforms in production and development use throughout the semiconductor industry, today announced availability of its UPF Elaborator. The new functionality broadens the capabilities of Verific's UPF Parser/Analyzer, available since 2014 and in production use within several chip design flows. It complies with the IEEE 1801-2015 standard (UPF 3.0) as well as previous versions 1.0, 2.0 and 2.1. Lawrence Neukom, senior member of technical staff at Verific, is a co-author of the standard and a voting member of the IEEE 1801 UPF Working Group. "As engineering groups have found, UPF eases specification, simulation and verification of chip designs with power intent in mind. Our new UPF Elaborator extends our support for UPF by providing access to a power-aware netlist." The Verific UPF Parser/Analyzer reads a UPF specification command by command, maintaining line and file origination information, and executes syntax and semantic checks to ensure correctness of the UPF specification. The result is a resolved power-intent model. The UPF Elaborator applies the power-intent model to the original hardware design language (HDL) design. The result is a power-aware netlist with new instantiations of power-related cells, as well as any required supply network and corresponding control path logic. UPF concepts elaborated in an HDL design by Verific's UPF Elaborator include logic and supply ports and nets, power switches, retention, isolation, level-shifter and repeater cells. Verific's SystemVerilog, VHDL and UPF parsers are in production and development flows throughout semiconductor companies worldwide, from emerging companies to established Fortune 500 vendors. Applications range from analysis, simulation, formal verification and synthesis to emulation and virtual prototyping, in-circuit debug and design for test. Verific distributes its Parser Platforms as C++ source code and compiles on all 32 and 64 bit Unix, Linux, Mac and Windows operating systems. Verific will exhibit at the Design Automation Conference (DAC) in Booth #639 June 19-21 from10 a.m. until 6 p.m. at the Austin Convention Center in Austin, Texas. DAC attendees are invited to visit the Verific booth to learn more about the new Elaboration Module and its Parser Platforms and pick up this year's giraffe giveaway. To schedule an appointment, contact Rick Carlson, Verific's vice president of sales. He can be reached at (970) 948-9650 or via email at rick@verific.com. More information can be found on the Verific website. About Verific Design Automation Verific Design Automation, with offices in Alameda, Calif., and Kolkata, India, provides SystemVerilog, Verilog, VHDL and UPF Parser Platforms that enable project groups to develop advanced electronic design automation (EDA) products quickly and cost effectively. Since 1999, Verific has shipped more than 60,000 copies of its software used worldwide by the EDA and semiconductor industry. Corporate headquarters is located at: 1516 Oak Street, Suite 115, Alameda, Calif. 94501. Telephone: (510) 522-1555. Email: info@verific.com Website: www.verific.com Or, follow Verific on Facebook: https://www.facebook.com/Verific-Design-Automation-100448363329771/ Verific Design Automation acknowledges trademarks or registered trademarks of other organizations for their respective products and services.


News Article | May 24, 2017
Site: phys.org

Brown clothing dyes made from sorghum husks (top row) closely match the colors of synthetic dyes (bottom row). Credit: American Chemical Society Sorghum has long been a staple food in many parts of the world, but in the U.S., it's best known as a sweetener and livestock feed. As demand for the grain soars, so does the amount of waste husks. To reduce this waste, scientists report in the journal ACS Sustainable Chemistry & Engineering a new use for it: a wool dye that can add ultraviolet protection and fluorescence properties to clothing. Sorghum, which looks like pearl couscous, is a hardy, drought-tolerant crop that is gaining popularity as a health food, livestock feed and source of bioethanol. Additionally, scientists are working on transforming the crop's waste for a range of applications, including food coloring and waste water purification. Building further on the colorant possibilities, Yiqi Yang, Xiuliang Hou and colleagues wanted to see if they could develop a practical clothing dye out of sorghum husks. The researchers tested extracts of husks on wool materials, which turned varying shades of brown. The dyes showed good colorfastness even when the wool was washed, rubbed and ironed. They also added UV protection and fluorescence properties to the materials, which withstood 30 cycles of laundering. More information: Xiuliang Hou et al. Potential of Sorghum Husk Extracts as a Natural Functional Dye for Wool Fabrics, ACS Sustainable Chemistry & Engineering (2017). DOI: 10.1021/acssuschemeng.6b02969 Abstract We report a novel application of sorghum husk extracts (SHE) as a natural functional dye for wool fabrics. Sorghum husk is an abundant, cheap and readily available agricultural byproduct. A small proportion of sorghum husk has been used to extract food colorants. In order to add value to sorghum and decrease environmental pollution, a number of investigations need to be undertaken to explore newer application for the husk. This paper investigated the stability of SHE, the colorfastness, UV-protection and fluorescence properties of dyed wool fabrics with SHE by different dyeing methods. SHE had good thermal and pH stability suitable for the dyeing and finishing processes of textiles. Wool fabrics dyed directly or with Al3+ and Fe2+ mordant demonstrated good colorfastness to washing, to rubbing, to wet ironing and acceptable colorfastness to light. The dyed wool fabrics showed good UV-protection and fluorescence properties. After 30 home laundering cycles, the UV-Protection Factor (UPF) and fluorescence intensity of wool fabrics dyed with SHE were still remarkably higher than those of wool fabrics dyed with mixed synthetic dyes with similar shade and depth and undyed fabric. SHE would be a feasible alternative for some synthetic dyes and functional finishing agent.


KANSAS CITY, Mo.--(BUSINESS WIRE)--Fair & Fashionable is kicking off May Skin Cancer Awareness Month by awarding its “Best Sun Protection” seal to Sol La La, a women’s sun-safe fashion brand. Fair & Fashionable’s goal is to show that real style means celebrating natural skin tones. The organization’s seal recognizes products that offer effective and fashionable sun protection. According to the American Academy of Dermatology: Drs. Molly Menser and Brian Matthys started Fair & Fashionable out of concern for the increase in skin cancer cases among their female patients. Fair & Fashionable uses fashion as a way to encourage daily sun protection and tanning avoidance. Sol La La offers chic and sunsmart apparel for women seeking sun protection without compromising style. The fashion line and exclusive UPF fabric, SansolTM, are made-in-America from eco-friendly cotton and beechwood fibers resulting in ultra soft, lightweight and breathable fabric that blocks 97% of harmful UV rays. “Sol La La is thrilled to receive the Fair & Fashionable ‘Best Sun Protection’ seal to kick off Skin Cancer Awareness Month,” said Abby Auerbach, creator and CEO, Sol La La. “We’re committed to women’s fashion sense while protecting them from harmful UV rays. Sol La La styles add sun protection to Sol Sisters’ favorite outfits without having to reapply. Like sunglasses, simply slip on a Sol La La accessory and ‘step into the sun.’ We support Fair & Fashionable’s mission wholeheartedly!” “Sol La La meets our strict scientific requirements to protect from UVA and UVB rays - during May Skin Cancer Awareness Month and every day,” said Dr. Molly Menser, president and co-founder, Fair & Fashionable. “The styles have broad spectrum protection, they’re stylish and comfortable to wear. We applaud Abby’s team for their contributions to the prevention of skin cancer and are delighted to award Sol La La the Fair & Fashionable ‘Best Sun Protection’ seal.”


News Article | March 1, 2017
Site: www.marketwired.com

With on-trend style, easy shopping tools, coverage options and smart control, Lands' End helps women hit the beach with confidence DODGEVILLE, WI--(Marketwired - Mar 1, 2017) - One piece, tankini or bikini? Plus size, tall or petite? Perhaps a little tummy control? Lands' End ( : LE) now offers women more choices in swimwear -- and easy online shopping tools -- so they'll not only look great, but feel confident in their swimwear. Lands' End has launched its 2017 swim collection with on-trend styles designed with every body, taste and need in mind. Swimwear that Suits "Whether she's looking for swimwear with minimal coverage or targeted control, we want her to be confident -- to know that she's got a suit that uniquely suits her," said Pierre Colorado, divisional merchandise manager for swim, Lands' End. "We've created nine swim collections with endless options -- from cover-ups to control suits -- so that this swim season, there's truly something for every body." Dive Into Swim Lands' End swim is now easier to shop with an advanced, mobile-friendly Swim Finder tool providing personalized swimsuit recommendations based on body shape, silhouette, coverage, control and more. Women can also shop myriad styles that are available in sizes ranging from 0 to 26W, G-cup, petite, tall, tall plus, and mastectomy. With its largest assortment of two-piece bikini and tankini swimsuit options, Lands' End has also launched a new Mix & Match tool to build the perfect swimsuit. Whether by computer or mobile device, women can visually pair bikini and tankini tops with the collection's assortment of bottoms by simply scrolling back and forth between pieces, then selecting the color. Swimming in Style Nine complete swimwear collections offer style to suit any taste. From the feminine detailing in the Sea & Sky, Costa D'Oro and Lands' End Canvas collections to athletic styles in the LE Sport and AquaSport collections, women have more options in form and function. The Slender Suit® and Shape & Enhance™ collections feature comfortable control in modern silhouettes, prints and colors. Clever "line art" textured fabric in the Texture collection functions as swimwear camouflage, smoothing any shape. Build Your Perfect Suit with Beach Living® By far the largest collection from Lands' End swim, Beach Living offers an extensive assortment of tops and bottoms that customers can mix and match to create the perfect swim wardrobe. Beach Living takes women from the pool to the party with coordinating swim and cover-up options. As an added bonus, all Beach Living separates feature UPF 50 protection plus various control and bra options throughout. Among many new highlights, the flattering Squareneck Tankini is available in an on-trend Scuba Blue Foulard Stripe that features deep navy, lime and turquoise patterned stripes. A new Swim Tee in Deep Sea Placed Italian Floral places a beautiful yellow and blue floral print over a solid navy long-sleeved shirt. Swimwear Standouts Style abounds throughout the entire Lands' End swim collection. Several standout pieces in the Sea & Sky, LE Sport, Lands' End Canvas and Costa D'Oro push the style quotient. High-neck bikini tops, reversible print/solid fabrics, cropped rash guards, cut-out monokinis, wrap-around and lace-up details make the Sea & Sky collection the fashion leader. Inspired by the Italian coast, the Costa D'Oro collection features striking florals, feminine details such as ruffles, and high-waist bikini bottoms to help her freshen any swim wardrobe with style. The athletic-inspired Long Sleeve Zip Front One Piece Swimsuit from LE Sport completely covers the torso in style and sun protection while looking sporty and on-trend. It's also available in a sleeveless style with colorblocking. Dress details and Hollywood glamour abounds in the Lands' End Canvas collection. Lattice details add softness to one-piece swimsuits while keyholes in bikini tops and high-waist bottoms add a touch of drama. Clever Cover-Ups Lands' End swim cover-ups are so stylish that women wear them to the pool, pool party and beyond. There's a cover-up for every suit -- from floral and ombre caftans to a button-front boyfriend shirt, even swim shorts. For full, neck-to-ankle coverage, women can pair a UPF 50 rash guard with cover-up crop leggings that feature an attached skirt. Smart Design, Quality, Guaranteed. Period. The experts at Lands' End swim look at every stitch, every detail to ensure quality, function and fashion. From control swimsuits that are woven to provide control exactly where it's needed to bra cup options, long torso suits, mastectomy and maternity friendly options, designers work hard to ensure every woman fits in -- and fits in style -- at Lands' End. About Lands' End, Inc. Lands' End, Inc. ( : LE) is a leading multi-channel retailer of clothing, accessories, footwear and home products. We offer products through catalogs, online at www.landsend.com, www.landsendcanvas.com, and affiliated specialty and international websites, and through retail locations, primarily at Lands' End Shops at Sears® and standalone Lands' End Stores. We are a classic American lifestyle brand with a passion for quality, legendary service and real value, and seek to deliver timeless style for men, women, kids and the home. To view this release in a media-rich format, go to: http://landsend.new-media-release.com/2017swimwear/


News Article | February 23, 2017
Site: www.eurekalert.org

A study led by researchers at the Hospital del Mar Medical Research Institute (IMIM) and the Institute of Medical Physics and Biophysics at the Faculty of Medicine in Charité Hospital, Berlin, published in the journal Nature Communications, demonstrates that the cholesterol present in cell membranes can interfere with the function of an important brain membrane protein, through a previously unknown mode of interaction. Specifically, cholesterol is capable of regulating the activity of the adenosine receptor, by invading it and accessing the active site. This will allow new ways of interacting with these proteins to be devised that in the future could lead to drugs for treating diseases like Alzheimer's. The adenosine receptor belongs to the GPCR family (G Protein-Coupled Receptors), a large group of proteins located in cell membranes, which are key in the transmission of signals and communication between cells. GPCRs are therefore involved in the majority of important physiological processes, including the interpretation of sensory stimuli such as vision, smell, and taste, the regulation of the immune and inflammatory system, and behaviour modulation. "Cholesterol is an essential component of neuronal membranes, where GPCRs reside along with other proteins. Interestingly, the levels of cholesterol in the membrane are altered in diseases such as Alzheimer's, where GPCRs like the adenosine receptor play a key role", explains Jana Selent, head of the GPCR Drug Discovery research group at the GRIB, a joint programme between Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF). "This study has shown that cholesterol can exert direct action on this important family of proteins in neuronal membranes, the GPCRs, and establishes the basis for a hitherto unknown interaction pathway between the cell membrane and proteins", adds the researcher. Up to now, it was thought that membrane cholesterol could regulate the activity of these proteins through two mechanisms: either by altering the physical properties of the membrane, or by binding to the surface of the protein. In both cases, it was thought that cholesterol could only exercise its modulatory action from outside the protein. However, by using latest-generation molecular simulations the researchers were able to detect the fact that cholesterol can leave the neuronal membrane and get within the adenosine receptor, in particular accessing the receptor's active site. With this information, and in collaboration with Dr. Mairena Martin and Dr. José L. Albasanz from the University of Castilla-La Mancha, we designed an experimental protocol using cell assays to demonstrate that cholesterol is able to modulate the activity of this receptor by accessing its interior. "Cholesterol levels in cell membranes could have a more direct effect than previously thought on the behaviour of key proteins in central nervous system diseases. In particular, high levels of membrane cholesterol like those present in Alzheimer's patients probably block the adenosine receptor, which could in turn be related to certain symptoms observed in this disease", explains Ramón Guixà González, a postdoctoral researcher at the Institute of Medical Physics and Biophysics at the Faculty of Medicine in Charité Hospital in Berlin and first author of the article. "Although other studies are needed to prove this relationship, this work provides key knowledge that could be used in the future in the development of new molecules that, like cholesterol, have the ability to get inside the receptor and modulate its activity", says the researcher. The results from this study represent a paradigm shift in the relationship between membrane cholesterol and GPCRs in the central nervous system, and open up new avenues of research in fields where the cholesterol-GPCR relationship is essential. It also appears that the cholesterol access pathway into the receptor is an evolutionary footprint. It is therefore necessary to discover whether the molecular mechanism described in this paper is present in other GPCRs and therefore potentially involved in a wide range of central nervous system diseases. Guixà-González R, Albasanz JL, Rodríguez-Epigares I, Pastor M, Sanz F, Martí-Solano M, Manna M, Martínez-Seara H, Hildebrand PW, Martí M, Selent J. Membrane cholesterol access into a G-protein-coupled receptor. Nature Communications, 8:14505, 2017. (DOI: doi:10.1038/ncomms14505) Explanatory video in which you can see how cholesterol leaves the neuronal membrane and get within the adenosine receptor: https:/


JACKSON, MS / ACCESSWIRE / February 21, 2017 / Bahamas Development Corporation (OTC PINK: BDCI) has executed an Asset Purchase Agreement (APA) to acquire a U.S. based wholesale performance wear apparel manufacturing company. The apparel manufacturing company currently generates approximately $100,000 a month in revenue. The apparel manufacturing acquisition announced today complements the previously announced acquisition of a fast-growing wholesale turnkey performance lifestyle apparel company, which itself generates approximately $1 million per year in revenue. While both companies focus on the "HOT" Athleisure category, each has its own existing operations and distribution channels. Both companies are synergistic in nature, and the acquisitions have been structured to avoid any dilution to BDCI. The apparel manufacturing company being acquired specializes in "MADE IN THE USA", 100% moisture wicking mesh polyester performance wear with UPF 40 Sun Protection, and dye sublimation printing. Services include creative, dye sublimation printing, cut and sew operations, custom packaging/labeling and fulfillment. The company manufactures private branded and co-branded apparel and services several clients. Sales are made through multiple websites, and other wholesale channels. Current customers include major fishing, marine & outdoor retail stores, marinas, special events, hospitality, agriculture, team sports, diving, and the U.S. military. As a result of the acquisition, BDCI expects to achieve economies of scale both with respect to raw material purchases, as well as other manufacturing processes. BDCI also aims to build and rollout new websites in order to expand its combined trademarked brands and to reach out directly to retail customers. The rise in Athleisure has given apparel sales a significant boost in the last couple of years. In 2014, US consumers spent $323 billion on apparel, footwear and accessories, according to The NPD Group. This was a $2 billion increase from the prior year, and largely thanks to dramatic growth in sales of activewear. Morgan Stanley predicts that, by 2020, activewear will represent $83 billion in sales, "stealing market share from non-athletic apparel." According to Stylus, "The Athleisure phenomenon looks set to continue into 2016 and beyond, and is now on course to become one of the fastest-growing global apparel product categories in the second half of this decade." Bahamas Development Corporation, in compliance with SEC regulations, may in the future use social media outlets like Facebook or Twitter and its own website to announce key information in compliance with Reg FD. For additional information about this release please contact: This news release contains "forward-looking statements" as that term is defined in Section 27(a) of the United States Securities Act of 1933, as amended and Section 21(e) of the Securities Exchange Act of 1934, as amended. Statements in this press release which are not purely historical are forward-looking statements and include any statements regarding beliefs, plans, expectations or intentions regarding the future. Such forward-looking statements include, among other things, estimates of services and equipment markets, release of corporate apps, growth of platform, target markets, product releases, product demand and, business strategy. Actual results could differ from those projected in any forward-looking statements due to numerous factors. Such factors include, among others, the inherent uncertainties associated with new projects and development stage companies. These forward-looking statements are made as of the date of this news release, and we assume no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those projected in the forward-looking statements. Although we believe that any beliefs, plans, expectations and intentions contained in this press release are reasonable, there can be no assurance that any such beliefs, plans, expectations or intentions will prove to be accurate. Investors should consult all of the information set forth herein and should also consider that any investment in securities is at risk. Details of the Company's business, finances, appointments and agreements can be found as part of the Company's continuous public disclosure on otcmarkets.com.


News Article | February 15, 2017
Site: www.prweb.com

ReelSkinz has updated it's website to proudly showcase it's vibrant, bright, and unique colors of high performance fishing shirts. Fishermen have been taking advantage of ReelSkinz outdoors fishing apparel since it launched in 2011 in Miami, Florida. They capture the beauty of real fish skins caught in the wild and place them on their high performance fishing apparel without any digital manipulation. Each fishing shirt sold by ReelSkinz has it's own unique story that starts at the first tug of the fishing line. Every fishing shirt includes SPF/UPF 50 weaved into every stitch to ensure maximum sun protection while out on the boat trying to catch the fish of the day. ReelSkinz has revamped their entire website to offer fishermen the ideal fishing gear for the outdoors lifestyle. Not only did ReelSkinz do a facelift on their website, but they added new performance fishing shirts and outdoor fishing gear for its fans. ReelSkinz is more than just a brand, they built themselves around the community of fishermen around the world. With an ever growing social media presence on Instagram has allowed them to hear instant feedback with its fishing fans. In addition, ReelSkinz has become a proud partner of 1% For The Planet, an organization that focuses on helping the oceanic wildlife community. There is no better way to give back to the open waters we love and enjoy so much. ReelSkinz added a new line of high performance fishing shirts that include vibrant colors such as hot coral, ocean blue, and neon orange to it's collection. ReelSkinz found it imperative to add new fishing gear to its line including their newly popular fishing face shields, which offer the ultimate sun protection to keep on fishing. These fishing masks are lightweight and can be worn multiple ways to help keep fishermen cool out on the open water while fishing all day. These fishing face shields come in swordfish, mahi, bass, blackfin tuna, and many of our other vibrant fish skins. Alongside ReelSkinz website relaunch they have added multiple way to purchase all of their high performance fishing apparel online. Their goal is to make it as easy as possible for fishing fanatics to buy and show off their new fishing shirts out on the boat. During checkout ReelSkinz offers Amazon Payments and Paypal to offer secure and quick checkouts. They also understood how important it was to be mobile friendly in todays internet world and have made their website 100% mobile. Consider shopping for all outdoor fishing apparel on the go as easy as ever. Don't wait any longer to check out ReelSkinz brand new fishing apparel website. Check out ReelSkinz to see their entire new line of high performance fishing shirts. They have even added a fresh off the boat sale section to their online store. Every time ReelSkinz introduces new fishing apparel they first put them on sale so all of their fans can get the first chance at reeling them in. These brand new fishing shirts are only on sale for a limited time before they are added to the normal fishing apparel line. Don't wait any longer to check out ReelSkinz brand new website and grab the newest high performance fishing shirts.


News Article | February 22, 2017
Site: phys.org

Arrestin loops interact directly with the membrane adjacent to the GPCR. Credit: Jana Selent, Pompeu Fabra University. Researchers from Charité – Universitätsmedizin Berlin have been studying two proteins that play a vital role in many bodily processes. The aim of the research was to establish how G-protein-coupled receptors (GPCRs) and arrestin form complexes. The human GPCR family consists of nearly one thousand different types of membrane proteins, with the majority involved in sensory and neuronal processes. Results from this research, which has been published in the current issue of the journal Nature Communications, identify a previously unknown binding element critical to the arrestin - GPCR interaction. As crucial drug targets, G-protein-coupled receptors are responsible for the effectiveness of nearly half of all medicines prescribed today. GPCRs are integral membrane proteins that control and modulate the processing of sensory and physiological stimuli, such as those relevant to our sight and taste, or those involved in controlling our heart rate. Arrestins play a key role in controlling the activity and signal transduction of GPCRs inside the cells of the body. "GPCRs are the target of a wide variety of drug-based treatments, which is why it is so important for us to understand their structure and function, and to fully understand how these membrane proteins interact at the molecular level. In order to develop better drugs with fewer side effects, this knowledge is necessary," explains Dr. Martha Sommer, who chairs the Arrestin Working Group at Charité's Institute of Medical Physics and Biophysics. Some of the side effects that occur with certain medicines (such as morphine-based drugs) are the result of arrestin-dependent signaling pathways. The researchers' close observation of the interactions between arrestins and GPCRs yielded crucial conclusions. "We asked ourselves how these two proteins manage to find each other, and what happens when they come together to form a complex. The recent crystal structure of a GPCR-arrestin complex prompted us to ask whether a section of arrestin called the C-edge might interact with the membrane adjacent to the GPCR," explains Dr. Sommer. "Using a combination of computer simulations, which we conducted in cooperation with Dr. Jana Selent at the UPF Barcelona, and site-directed fluorescence spectroscopy, we were able to show that loops within the C-edge of arrestin binds to the membrane." The existence of this type of interaction was previously unknown, and its discovery opens up a whole new field of research regarding how the membrane influences the function of arrestin. A better understanding of GPCR-arrestin interactions is essential if we are to develop drugs with fewer side effects. Dr. Sommer's team have already begun to explore the role of the membrane on the structure and interactions inside the GPCR-arrestin complex. More information: Ciara C M. Lally et al, C-edge loops of arrestin function as a membrane anchor, Nature Communications (2017). DOI: 10.1038/ncomms14258


News Article | February 22, 2017
Site: www.eurekalert.org

Researchers from Charité - Universitätsmedizin Berlin have been studying two proteins that play a vital role in many bodily processes. The aim of the research was to establish how G-protein-coupled receptors (GPCRs) and arrestin form complexes. The human GPCR family consists of nearly one thousand different types of membrane proteins, with the majority involved in sensory and neuronal processes. Results from this research, which has been published in the current issue of the journal Nature Communications*, identify a previously unknown binding element critical to the arrestin - GPCR interaction. As crucial drug targets, G-protein-coupled receptors are responsible for the effectiveness of nearly half of all medicines prescribed today. GPCRs are integral membrane proteins that control and modulate the processing of sensory and physiological stimuli, such as those relevant to our sight and taste, or those involved in controlling our heart rate. Arrestins play a key role in controlling the activity and signal transduction of GPCRs inside the cells of the body. "GPCRs are the target of a wide variety of drug-based treatments, which is why it is so important for us to understand their structure and function, and to fully understand how these membrane proteins interact at the molecular level. In order to develop better drugs with fewer side effects, this knowledge is necessary," explains Dr. Martha Sommer, who chairs the Arrestin Working Group at Charité's Institute of Medical Physics and Biophysics. Some of the side effects that occur with certain medicines (such as morphine-based drugs) are the result of arrestin-dependent signaling pathways. The researchers' close observation of the interactions between arrestins and GPCRs yielded crucial conclusions. "We asked ourselves how these two proteins manage to find each other, and what happens when they come together to form a complex. The recent crystal structure of a GPCR-arrestin complex prompted us to ask whether a section of arrestin called the C-edge might interact with the membrane adjacent to the GPCR," explains Dr. Sommer. "Using a combination of computer simulations, which we conducted in cooperation with Dr. Jana Selent at the UPF Barcelona, and site-directed fluorescence spectroscopy, we were able to show that loops within the C-edge of arrestin binds to the membrane." The existence of this type of interaction was previously unknown, and its discovery opens up a whole new field of research regarding how the membrane influences the function of arrestin. A better understanding of GPCR-arrestin interactions is essential if we are to develop drugs with fewer side effects. Dr. Sommer's team have already begun to explore the role of the membrane on the structure and interactions inside the GPCR-arrestin complex. Dr. Martha Sommer Institute of Medical Physics and Biophysics / Chair of the Arrestin Working Group (AG Arrestin) Charité - Universitätsmedizin Berlin Tel: +49 30 450 524 200 Email: martha.sommer@charite.de

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