Garces-Eisele J.,UPAEP University
Hematology | Year: 2012
The prognostic significance of minimal residual disease (MRD) has been demonstrated for a variety of hematologic malignancies. PCR based assays are among the most important methods for identifying MRD. They are aimed at detecting genetic abnormalities of residual leukemic cells with high specificity and sensitivity and represent an important diagnostic tool to assess the quality of therapeutic response, for clinical risk assessment, and for clinical management. In the present review technical aspects of different MRD detection methods are discussed which depend on the available targets regularly present in the respective leukemia type and subtype. As such fusion transcripts, gene mutations, and clonal rearrangements of antigen-receptor genes may be available for detection. Emphasis is given on discussing benefits and limitations of MRD detection and quantification in CML, AML and ALL. © W. S. Maney & Son Ltd 2012.
Index of Nutritional Purchasing Power Parity: Comparison of caloric costs of a healthy versus an unhealthy diet [Índice de Paridad Poder de Compra Nutricional: comparación de los precios calóricos entre dietas habituales y saludables]
Velazquez A.M.,UPAEP University
Revista Panamericana de Salud Publica/Pan American Journal of Public Health | Year: 2012
Objective: Develop the Index of Nutritional Purchasing Power Parity (Nut3-CiO) as an instrument to compare the caloric costs of a healthy versus an unhealthy diet between regions or cities in a country over time. Methods: Indices of caloric prices were constructed and the "law of one price" was used to derive the Nut3-CiO index. Caloric inflation rates were obtained using basic descriptive statistics. The Nut3-CiO was applied in the major cities of Mexico during the period from January 1996 to December 2010. Results: The statistical behavior of the Nut3-CiO revealed that, in Mexican cities, products for a typical diet are less expensive than products for a healthy diet. The findings showed a cyclical behavior to the index, a high correlation between inflation for the typical diet and inflation for the market basket, and a high persistence of prices. Conclusions: The Nut3-CiO index makes it possible to periodically compare the price differential of two types of diets-typical and healthy-between cities in a single country. This instrument could help health authorities identify the cities where it is easier or more difficult for consumers to access a typical or healthy diet in terms of cost. Furthermore, it makes it possible to estimate the percentage adjustment necessary in each city to attain levels of nutritional purchasing power parity.
Castro-Manzano J.M.,UPAEP University
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2013
We present the initial results of a series of studies around the concept of computational political philosophy. We show a computational interpretation of three classical models of political philosophy that justify three different forms of government by implementing some experiments in order to provide evidence to answer the question of which political philosophy proposes a more plausible form of government. We focus in the relation commitment vis-à-vis earnings and we observe that although some political philosophies would justify highly united (communal) or highly competitive (liberal) communities, they would not necessarily imply societies with a reasonable level of welfare. © 2013 Springer-Verlag.
Ruiz-Arguelles A.,UPAEP University
Hematology | Year: 2012
Minimal residual disease refers to the tumour cells that are still present in a given patient after completion of a therapeutic scheme. The demonstration and quantification of residual neoplastic cells has a crucial impact in clinical decision making, for it might prompt continuation of treatment, while the absence of such cells might serve as evidence to withdraw therapy. Therefore, both sensitivity and specificity of the methods used to unravel residual neoplastic cells must be highly reliable and robust. Flow cytometry has been widely used for this purpose, and its clinical performance depends mainly on the criteria of interpretation, rather than in the technique by itself; molecular biology techniques have proved to be highly sensitive and specific but unfortunately they cannot be used in all patients or in all types of leukemia. Finally, the development of donor cell leukemia in transplanted patients, might mimic residual disease and add more confusion to an already controversial issue. These topics are discussed in this paper. © W. S. Maney & Son Ltd 2012.
Ordenana-Martinez A.S.,UPAEP University |
Rincon M.E.,National Autonomous University of Mexico
Journal of Solid State Electrochemistry | Year: 2016
In this paper, we report the preparation and characterization (morphological, structural, surface, and electrochemical) of multiwalled carbon nanotube (MWCNT)/carbon xerogel (CX) electrodes prepared by mixing. This research proposes the hypothesis that the use of a hydrophilic binder (nafion) and the use of MWCNTs enhance electrode capacitance and conductivity. Electrochemical measurements in 2 M NaCl solution were performed. The advantage of adding multiwalled carbon nanotubes to the array of xerogel-nafion was studied through different electrochemical methods. It was validated that the greater carbon nanotube mesoporosity allows less compaction of the electrode, thus effectively increasing the specific area and therefore capacitance. Furthermore, we observed the increase in electronic conductivity reported in numerous studies, a fact that is true for iR drop measurement cycles in both galvanostatic charging and discharging. The carbon composite proved to be viable for energy storage. © 2016 Springer-Verlag Berlin Heidelberg