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Kumar A.,UP Pt Deen Dayal Upadyay Pashu Chikitsa Vishwavidyalaya Evam Gau Anusandhan Sansthan DUVASU | Rahal A.,Indian Veterinary Research Institute | Zoheb S.M.,UP Pt Deen Dayal Upadyay Pashu Chikitsa Vishwavidyalaya Evam Gau Anusandhan Sansthan DUVASU | Prakash A.,UP Pt Deen Dayal Upadyay Pashu Chikitsa Vishwavidyalaya Evam Gau Anusandhan Sansthan DUVASU | Mandil R.,UP Pt Deen Dayal Upadyay Pashu Chikitsa Vishwavidyalaya Evam Gau Anusandhan Sansthan DUVASU
Toxicological and Environmental Chemistry | Year: 2014

This study aimed to evaluate the reparative potential of ascorbic acid (AA, 100 mg/kg, orally for 28 days) in sub-acute lead (Pb, 100 ppm in drinking water for 28 days) or cypermethrin (CPM, 50 mg/kg, orally in vehicle for 28 days) poisoning alone and as binary mixture on the basis of oxidative stress parameters in erythrocytes of Wistar rats. Both Pb and CPM produced significant increase in lipid peroxidation along with elevated glutathione-S-transferase and catalase activity individually but not as a binary mixture. Glutathione peroxidase activity was significantly increased but glutathione levels were significantly reduced irrespective of single or co-exposure while the activity of superoxide dismutase and erythrocytic protein content were not significantly affected. Co-exposure led to a comparatively lower level of oxidative stress than that induced by Pb or CPM alone indicating an antagonistic toxicodynamic profile in rat erythrocytes. Co-administration of AA along with Pb and/or CPM significantly restored the oxidative stress parameters to normal values. Overall results indicated that co-exposure induces a lower level of oxidative stress and AA ameliorates Pb- and/or CPM-induced oxidative damage in rat erythrocytes. © 2015, © 2015 Taylor & Francis. Source

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