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Di Folco U.,UOS di Diabetologia con DH Azienda Ospedaliera | Morviducci L.,UOS di Diabetologia con DH Azienda Ospedaliera | Nardone R.,UOS di Diabetologia con DH Azienda Ospedaliera | Hassan O.,UOS di Diabetologia con DH Azienda Ospedaliera | Tubili C.,UOS di Diabetologia con DH Azienda Ospedaliera
Giornale Italiano di Diabetologia e Metabolismo | Year: 2014

In type 1 diabetes mellitus the prandial insulin bolus must be adjusted to the carbohydrate (CHO) intake in order to achieve postprandial glucose targets, prevent late-onset hypoglycemia, and maintain good metabolic control. We studied 64 type 1 diabetic patients treated with multiple daily injections (MDI), in poor metabolic control, to assess the efficacy of an automated bolus calculator. After individual training in CHO counting, the patients were randomly divided into two groups of 32; group A calculated the insulin bolus with the automated bolus calculator, while group B established it empirically. All the subjects checked their fasting (FBG) and postprandial (PBG) capillary glucose daily, and recorded any hypoglycemic episodes (< 70 mg/dl); HbA1c was assayed after four months.At the end of the study FBG and PBG were significantly lower in group A than group B; HbA1c fell 1.1%, a drop of 13.5% from the start (p < 0.006) and no hypoglycemia was reported. The automated bolus calculator improved metabolic control and efficiently prevented postprandial late-onset hypoglycemia in type 1 MDItreated diabetics. @#x00A9; 2014 UTET Periodici Scientifici srl.All rights reserved.

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