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Tatti P.,UOCA di Endocrinologia e Diabetologia | Di Mauro P.,UOCA di Endocrinologia e Diabetologia | Neri M.,UOCA di Endocrinologia e Diabetologia | Pipicelli G.,UOC Diabetologia e Dietologia | Mussad V.A.,Abbott Laboratories
Mediterranean Journal of Nutrition and Metabolism | Year: 2010

We treated 96 obese diabetic subjects (BMI 33-44 kg/m2) with a "package of interventions" including therapeutic education, regular follow-up at 15-day intervals and a hypocaloric diet of 60% of their daily needs, 20% at breakfast and 40% at each meal. At the beginning of the observation and after 3 and 6 months we checked certain baseline characteristics. All the subjects performed self blood glucose measurement (SMBG) 3 or 5 times a day and kept a log. After the first 3 months of observation (Phase 1) 18 were lost to follow-up and 40 who obtained a weight loss >5% of their initial BW continued on their diet (G-). The remaining 38 substituted a nutritionally rich hypocaloric meal (Glucerna® SR) for 206 calories of one of the main meals (G+). During the following three months (Phase 2) all were treated with the package of interventions. The subjects treated with Glucerna® SR had a more consistent weight loss and a more remarkable improvement of the parameters under evaluation, with greater statistical significance. With the logistic regression analysis the residual variance not explained by the weight loss was greater for the G+ group, which implies the existence of an additional beneficial effect of the formula used. Of great relevance is the observation that the G+ group had a reduction of the standard deviation of the SMBG data, thus suggesting a greater stability of the BG values in this group. © 2009 Springer-Verlag Italia. Source


Tatti P.,UOCA di Endocrinologia e Diabetologia | Di Mauro P.,UOCA di Endocrinologia e Diabetologia | Neri M.,UOCA di Endocrinologia e Diabetologia | Pipicelli G.,UOC Diabetologia e Dietologia | Strollo F.,U.O.C. di Endocrinologia
Mediterranean Journal of Nutrition and Metabolism | Year: 2010

Subjects with type 2 diabetes are in a continuous catabolic state due to increased neoglycogensis during most of the fasting and the postprandial period. We compared the body cell mass index (BCMI) of 257 subjects with type 2 diabetes mellitus (T2DM) and 216 non-diabetic controls and found a statistically significant lower value in the diabetic subjects. This abnormality was reversed after 6 months of treatment with a diabetes-specific nutritional formula. Furthermore, in a population of 715 diabetic subjects without other diseases, we found that the BCMI was inversely correlated with the prevailing HbA1c and the duration of the disease. © 2010 Springer-Verlag. Source


Tatti P.,UOCA di Endocrinologia e Diabetologia | Masselli L.,UOCA di Endocrinologia e Diabetologia | Di Mauro P.,UOCA di Endocrinologia e Diabetologia | Pipicelli G.,UOC di Diabetologia e Metabolismo | Strollo F.,U.O.C. di Endocrinologia
Mediterranean Journal of Nutrition and Metabolism | Year: 2011

Hypoglycemia is a frequent and often dramatic event in subjects with type 1 diabetes. It is also probable that an unrecognized nocturnal hypoglycemia may cause a marked variability of the fasting blood glucose. We used a nutritional formula with slow release carbohydrates represented by modified maltodextrins to reduce the risk of these events in 14 type 1 diabetic subjects. The continuous subcutaneous monitoring of interstitial glucose demonstrated a marked reduction in the number and depth of the hypoglycemic episodes throughout the 48 h when the formula was used versus the preceding 48 h. © 2011 Springer-Verlag. Source

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