San Raffaele Cimena, Italy
San Raffaele Cimena, Italy

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Solaro C.,PA Micone Hospital | Rezzani C.,Instituto Neurologico Nazionale Mondino | Trabucco E.,PA Micone Hospital | Amato M.P.,University of Florence | And 20 more authors.
Journal of the Neurological Sciences | Year: 2013

Objective: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system(CNS)with a chronic course. Dysphagia represents one of the current challenges in clinical practice for the management of MS patients. Dysphagia starts to appear in mildly impaired MS subjects (EDSS 2-3) and becomes increasingly common in the most severely disabled subjects (EDSS 8-9). The aim of the present study was to evaluate the frequency and characteristics of patient-reported dysphagia inMS patientswith a multicenter study using the recently developed DYMUS (DYsphagia in MUltiple Sclerosis) questionnaire. Design: Data were collected in a multi-centre, cross-sectional study using a face-to-face structured questionnaire for clinical characteristics and the DYMUS questionnaire. Results: 1875 patients were interviewed. The current study has shown a correlation between patient-reported dysphagia and EDSS and disease course but notwith age, gender and disease duration.Questionnaireswere divided into "patient-reported dysphagia-yes" (587, 31.3%) and "patient-reported dysphagia-no" (1288, 68.7%). Compared with the patient-reported dysphagia-no group, patients in patient-reported dysphagia-yes group had higher EDSS score (mean EDSS 4.6 vs. 2.8; p < 0.001) and had a longer disease duration (mean duration 13 years vs. 11 years; p < 0.001), while there was no significant difference in gender (32.7% vs. 30.5% male and 67.3% vs. 69.5% female) and in age composition (46.18 vs. 42.05). Conclusions: This study represents the largest, multi-centre sample ofMS patients evaluated for patient-reported dysphagia utilizing an ad-hoc questionnaire for this condition. © 2013 Published by Elsevier B.V.

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