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Genova, Italy

Berruti A.,University of Turin | Generali D.,Breast Cancer Unit | Kaufmann M.,Goethe University Frankfurt | Puztai L.,University of Houston | And 34 more authors.
Journal of the National Cancer Institute - Monographs | Year: 2011

A panel of international breast cancer experts formulated a declaration of consensus regarding many key issues in the use of primary systemic therapy (PST) either in clinical routine or research practice. The attainment of pathological complete response (pCR), defined as no residual invasive tumor in the surgical specimens both in breast and in axillary nodes, is one of the main goals of PST, and pCR can be used as the primary objective in prospective clinical trials. However, pCR is not a reliable endpoint with all treatment approaches, and alternatives such as Ki67 index of the residual invasive disease or after 2 weeks of PST are also potential endpoints. PST has several advantages: breast conservation and the unique opportunity to obtain information on the interaction between treatment and tumor biology. Changes in tumor biology after PST are an early phenomenon; so, an additional core biopsy performed after 14 days from treatment start should be considered in clinical trials. © The Author 2011. Published by Oxford University Press. All rights reserved. Source

Romano F.,U.O. di Pneumologia Oncologica | Scarlato M.I.,U.O. di Pneumologia Oncologica | Corno O.,U.O. di Endoscopia Toracica | De Donato P.,UO di Radiologia | Romeo F.,U.O. di Anatomia Patologica
Rassegna di Patologia dell'Apparato Respiratorio | Year: 2013

Rosai-Dorfman Disease, Sinus Histiocytosis with Massive Lymphadenopathy (SHML), is a rare histiocytic syndrome first described by Rosai and Dorfman, seen predominantly in childhood and early adulthood. Although considered a benign disease, fatalities may occur due to cellular infiltrates of vital organs. We report the case of a 21-year-old man presenting with dry cough, chest pain, oedema of the upper limbs, and axillary, inguinal and mediastinal lymphadenopathy. All immunologic examinations were negative. Lymphnode biopsy revealed the diagnosis of Rosai-Dorfman disease. Source

Palazzuoli A.,Sezione di Cardiologia | Beltrami M.,Sezione di Cardiologia | Sabini A.,U.O. di Cardiologia | Magnolfi A.,UO di Radiologia | Bucciarelli-Ducci C.,Bristol Heart Institute
Giornale Italiano di Cardiologia | Year: 2012

A 30-year-old male was evaluated in our hospital for the presence of transient palpitations. The ECG showed sporadic ventricular extrasystolic beats with normal ventricular depolarization and repolarization phases. Two-dimensional transthoracic echocardiography demonstrated a localized intraventricular myocardial mass (measuring 3 x 2 mm) in the basal lateral wall. To further characterize the mass, the patient was addressed to cardiac magnetic resonance imaging (MRI). Noninvasive myocardial tissue characterization with T2-weighted sequences (with and without fat suppression), and T1-weighted after contrast suggested the presence of fat tissue associated with undiversified muscle tissue. The intramyocardial mass was not capsulated and partially infiltrated the surrounding myocardium. The imaging features suggested the diagnosis of a benign myocardial mass with mixed aspects between cardiac hamartoma and lipoma. To monitor mass growth and in the absence of new symptoms, the patient is followed up yearly with transthoracic echocardiography, and with cardiac MRI exams every 3 years. This case highlights the utility of cardiac MRI to assess a myocardial mass non-invasively and delineate its anatomy and tissue characterization, which potentially avoids myocardial biopsy. © 2012 Il Pensiero Scientifico Editore. Source

Cappella M.,UOC di Pediatria e Neonatologia | Dal Bo S.,UOC di Pediatria e Neonatologia | Berretti L.,UO di Radiologia | Burnelli R.,SSD di Oncoematologia Pediatrica | Marchetti F.,UOC di Pediatria e Neonatologia
Medico e Bambino | Year: 2014

The paper reports the case of a 7-year-old child who presented with recurrent multifocal bone pain associated with low fever, elevation of flogosis indexes and negative standard radiological exams. The spectrum of differential diagnosis was wide. The magnetic resonance imaging (MRI) scan of his right knee and elbow revealed a multifocal areas of oedema-like bone marrow signal (abnormal hyperintensity on STIR images and abnormal hypointensity on T1-weighthed images). The main differential was exclusion of infection and malignancy. Bone marrow aspirate and biopsy was normal. Cultures from blood and bone biopsies were also negative. Bone biopsy was required and it showed chronic, non specific, aseptic inflammation. After ruling out acute or chronic infectious, malignancies, and benign bone tumors the final diagnosis was of chronic recurrent multifocal osteomyelitis (CRMO). The case highlights the importance of thinking about chronic nonbacterial osteomyelitis when a patient presents with recurrent episodes of unifocal or multifocal bone pain associated with fever. Source

Mele D.,U.O. di Cardiologia | Chiodi E.,UO di Radiologia | Lombardi M.,CNR Institute of Neuroscience | Bighi S.,UO di Radiologia | And 3 more authors.
Giornale Italiano di Cardiologia | Year: 2010

Cardiac resynchronization therapy (CRT) is a therapeutic option with proven efficacy in improving symptoms and reducing both hospitalization and mortality in patients with refractory heart failure. However, a significant number of patients do not respond to CRT and this may be due to incomplete or inappropriate selection and characterization of patients before pacemaker implant. Cardiac magnetic resonance imaging (CMRI) is an imaging technique that may assist cardiologists in this regard. This technique has the potential to improve the success rate of CRT, due to pre-interventional evaluation of left ventricular function, mechanical dyssynchrony, and characterization and quantification of scar tissue. Recently, venous coronary anatomy has also been successfully evaluated by CMRI. In this review the role of CMRI in patients with heart failure who are candidates for CRT is discussed and potential future developments are indicated. © 2010 AIM Publishing Srl. Source

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