Macchia D.,UO Allergologia Immunologia Clinica |
Capretti S.,UO Allergologia Immunologia Clinica |
Cecchi L.,Allergologia |
Colombo G.,Unita di Allergologia |
And 15 more authors.
Italian Journal of Allergy and Clinical Immunology | Year: 2011
Food allergy (FA) is an important problem due to its increasing prevalence in general population and to its broad range of clinical manifestations (from mild symptoms to anaphylactic shock, sometimes fatal). The identification of the food responsible for symptoms, using all the available standardized diagnostic methods, must be the main goal. The diagnosis of food allergy should be based on a correct procedure, that starts from a thorough clinical history and proceeds through the performance of in vivo and in vitro diagnostic methods, with a progressive level of complexity. The recent development of molecular biology techniques, that implies the use of molecular allergens, has improved the knowledge of food allergens and designs a component resolved sensitization profile (CRD: Component Resolved Diagnosis) for each patient, with important clinical and therapeutic consequences. However, the increasing use of in vitro routine tests based on molecular allergens runs the risk of possible, potentially serious mistakes. The Specialist in Allergology and Clinical Immunology should manage this complicated matter, after an adequate training. Therefore, a shared and standardized diagnostic pathway is mandatory. The aim of this position statement is to suggest the basic points in the adult food allergy diagnosis.