Univerzita Palackeho V Olomouci | Date: 2012-07-23
The two-step immobilisation of silver nanoparticles on solid substrates using polyethylenimine as adhesive and reduction linker, where the primary coating of solid substrates by polyethylenimine occurs followed by production of silver nanoparticles covalently anchored on polymer surface thanks to reduction effect of its functional groups and therefore, no nanoparticles are released to environment. The method permits working under aqueous conditions, does not use any reducing agents, stabilisers or toxic solvents and can universally be applied for anti-microbial treatments of all types of solid substrates.
Univerzita Palackeho V Olomouci, Ustav Organicke Chemie A Biocheme Akademie Ved Ceske Republiky and Ustav Molekularni Genetiky Akademie Ved Ceske Republiky | Date: 2012-10-24
Derivatives of boron cluster compounds of general formula I and their pharmaceutically acceptable salts and solvates, and their specific inhibition effect on the enzyme carbonic anhydrase IX, a protein overexpressed in cancer tissues. Methods of synthesis and the use of the novel derivatives. These inhibitors of human carbonic anhydrase IX can be used as active compounds of pharmaceuticals for diagnostics and/or therapy of cancer diseases.
Agency: Cordis | Branch: FP7 | Program: MC-CIG | Phase: FP7-PEOPLE-2012-CIG | Award Amount: 100.00K | Year: 2013
Photosynthesis is one of the most important biological processes on Earth. Photosystem I and Photosystem II are the key protein complexes in the photosynthetic or thylakoid membrane of chloroplasts for converting light energy. They mediate light-driven electron transport through the thylakoid membrane with help of additional light harvesting proteins. Both Photosystem I and II are organized into large supercomplexes with variable numbers of specifically attached membrane-bound light harvesting proteins. Under varying natural conditions plants have to regulate light harvesting to keep maximum efficiency of photosynthetic reactions under light limiting conditions and to prevent the photosynthetic apparatus from photooxidative damage under high light conditions. Acclimation and protective mechanisms involve considerable structural changes at the level of both individual photosynthetic proteins and the entire photosynthetic membrane, which are largely unexplored. Increasing our knowledge of stress induced structural changes of the photosynthetic apparatus is important for overall understanding of regulatory mechanisms of photosynthetic performance. Such information is of great importance to e.g. a booming field of artificial photosynthesis, which tries to mimic photosynthetic reactions at the laboratory conditions. The aim of proposed project is to monitor stress-induced structural changes (different light conditions, elevated temperature) of the plant photosynthetic apparatus at the level of individual supercomplexes of Photosystem I and Photosystem II and their associated antenna complexes using transmission electron microscopy and single particle image analysis. Another challenging aim of the research proposal is a visualization of stress-induced structural changes of (i) the overall organization and distribution of individual photosynthetic proteins within the thylakoid membrane and (ii) a folding of entire thylakoid membrane using cryo electron tomography.
Univerzita Palackeho V Olomouci | Date: 2011-09-02
The invention relates to 6-substituted 9-halogenalkyl purine derivatives of the general formula I wherein R6 is selected from the group comprising NH-furfuryl, NH-(4-hydroxy-3-methylbut-2-en-1-yl), NH-(3-methylbut-2-en-1-yl), NH-(4-hydroxy-3-methylbutyl), NH-(4-hydroxy-1,3-dimethylbut-2-en-1-yl), NH-(4-hydroxy-1,3-dimethylbutyl), NH-benzyl, NH-phenyl, wherein benzyl, furfuryl and phenyl can be unsubstituted or optionally substituted with 1 to 3 substituents selected from the group comprising hydroxy, halogen, methyl and methoxy, and R9 is selected from the group comprising C
Agency: Cordis | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2015 | Award Amount: 580.50K | Year: 2016
Substructural logics are formal reasoning systems that refine classical logic by weakening the structural rules in Gentzen sequent calculus. While classical logic generally formalises the notion of truth, substructural logics allow to handle notions such as resources, vagueness, meaning, and language syntax, motivated by studies in computer science, epistemology, economy, and linguistics. Moreover, from a theoretical point of view, substructural logics provide a refined perspective of classical logic, since the former often exhibit features which are either absent or trivialised in the classical case. Traditionally, substructural logics have been investigated following three main approaches: proof theoretic, algebraic and abstract study. Although some connections among these approaches were observed long ago, in large part these practices developed in independence. As a result, the research directions, tools and motivations for each approach developed in relative isolation. The main objective of this project is to establish a network of collaborations between the experts of these diverse methods to investigate substructural logics in a cohesive fashion, taking into account these three distinct yet complementary points of view. The main momentum for this endeavour is provided by recent surprising results that confirm how deeply algebraic and proof theoretic methods are linked to one another. The proposal gathers leading experts in all these three areas, from all around the word, with the aim of reuniting these traditions and their communities and obtain deep results in all three areas. We are confident that this innovative, combined perspective on substructural logics will have a deep impact on the field and that this project will provide a stable basis of cooperation for a large, international community of algebraists, logicians and theoretical computer scientists, giving fresh impetus to these disciplines to flourish and integrate.