Univerzita Palackeho V Olomouci | Date: 2017-03-29
The present invention provides a culture dish for the preparation of adherent cell line mounts on culture glass slides, wherein the bottom of said culture dish is provided with at least two spacers for maintaining the culture glass slides within a pre-defined space and with at least six distancing elements for preventing adhesion of the culture glass slides to the culture dish bottom due to capillary forces, said distancing elements having the height in the range of from 0.05 to 0.5 mm. The culture dish of the invention prevents the adhesion of the culture glass slides and allows smooth manipulation with the culture glass slides, while providing for the desired optical properties of the whole system allowing an unhindered observation of the adhered cells during the process of the preparation of the adherent cell line mounts.
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.87M | Year: 2016
In the face of the increasing global consumption of fossil resources, photosynthetic organisms offer an attractive alternative that could meet our rising future needs as clean, renewable, sources of energy and for the production of fine chemicals. Key to the efficient exploitation of these organisms is to optimise the conversion of Solar Energy into Biomass (SE2B). The SE2B network deals with this optimisation in an interdisciplinary approach including molecular biology, biochemistry, biophysics and biotechnology. Regulation processes at the level of the photosynthetic membranes, integrating molecular processes within individual proteins up to flexible re-arrangements of the membranes, will be analysed as a dynamic network of interacting regulations. SE2B will yield information about the similarities and differences between cyanobacteria, green algae, diatoms and higher plants, the organisms most commonly employed in biotechnological approaches exploiting photosynthetic organisms, as well as in agriculture. The knowledge gained from understanding these phenomena will be directly transferred to increase the productivity of algal mass cultures for valuable products, and for the development of sophisticated analytic devices that are used to optimise this production. In future, the knowledge created can also be applicable to the design of synthetic cell factories with efficient light harvesting and energy conversion systems. The SE2B network will train young researchers to work at the forefront of innovations that shape the bio-based economy. SE2B will develop a training program based on individual and network-wide training on key research and transferable skills, and will furthermore disseminate these results by open online courses prepared by the young researchers themselves.
Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-2012-1 | Award Amount: 1.62M | Year: 2012
The existing building stock in European countries accounts for over 40% of final energy consumption in the European Union (EU) member states, of which residential use represents 63% of total energy consumption in the buildings sector. In this scenario, the EcoThermo proposal will address specific needs and will pursue challenges in order to introduce breakthrough technologies into the market. The EcoThermo project aims to develop a smart thermoregulatory system aimed at optimizing the heat/cooling energy consumption and perform smart and accurate cost allocation to be applied in already existing (old) buildings where the heating/cooling system is centralized, without independent control and independent cost allocation even with a vertical pipeline distribution (i.e. each radiator connected to a different vertical pipe) avoiding the batteries and devices disposal and at the same time preserving a heating/cooling cost allocation really based on the user/flat thermal energy demand. Main Scientific Achievement: to research physical and mathematical models aimed to estimate with high accuracy the real demand of thermal energy by users (radiators, flats, etc.) connected to a common thermal generator and thermal distribution network and avoiding the usage of the traditional heat cost allocators (for each radiator) as well as the heat meters (for each flat); to research the physical phenomena in order to develop breakthrough technologies to electrically power flow control devices, such as radiator electronic valves, by the mean of transducers applied in main pipeline section and on board of the same peripheral control devices, avoiding the usage of batteries and the plug-in of the same devices to the grid and estimate the lowest energy demand for the most energy consumption device to be powered without plugging it on the electric power network
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.1.2-02 | Award Amount: 6.88M | Year: 2014
The project has been conceived to promote the culture of grain legumes in Europe by identifying priority issues currently limiting grain legume cultivation and devising solutions in term of novel varietal development, culture practices, and food uses. LEGATO will develop tools and resources to enable state of the art breeding methodology and to exploit fully the breadth of genetic resources available. The project will focus on a small number of key characters not previously explored in depth and complementary to other ongoing European and national projects. These topics covered include disease and pest resistance, where in addition to marker development for major fungal and viral pathogens, a focus on emerging insect pests is planned. The impact of end-of-season drought and heat stress on the rhizobial symbiosis, and its consequences for plant performance, will be studied. Two characters that can influence grain legume yield, autofertility and number of flowering nodes, will be investigated. The potential for improving legume nutritional and organoleptic quality by identification of desirable traits and innovative selection methods will be investigated. LEGATO will conceive sustainable legume-based cropping systems adapted to different pedoclimatic zones, respecting local constraints. The project has been constructed around the participation of commercial partners including SMEs in the areas of marker development, plant breeding, and legume food processing, who will benefit from the advances made in these areas in LEGATO. Promising legume varieties and cropping systems will be tested at a series of pan-european sites to favour the widest possible take-up in agriculture, and the partners potentially concerned will participate in a stakeholder forum convened regularly during the project.
R.Ø.S.A. and Univerzita Palackeho V Olomouci | Date: 2014-02-05
This invention relates to novel 2-substituted-6-biarylmethylamino-9-cyclopentyl-9H-purine derivatives, showing activity as specific inhibitors of growth and angiogenesis of hepatocellular carcinoma. The invention further includes pharmaceutical compositions containing the 2-substituted-6-biarylmethylamino-9-cyclopentylpurines.
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2015 | Award Amount: 580.50K | Year: 2016
Substructural logics are formal reasoning systems that refine classical logic by weakening the structural rules in Gentzen sequent calculus. While classical logic generally formalises the notion of truth, substructural logics allow to handle notions such as resources, vagueness, meaning, and language syntax, motivated by studies in computer science, epistemology, economy, and linguistics. Moreover, from a theoretical point of view, substructural logics provide a refined perspective of classical logic, since the former often exhibit features which are either absent or trivialised in the classical case. Traditionally, substructural logics have been investigated following three main approaches: proof theoretic, algebraic and abstract study. Although some connections among these approaches were observed long ago, in large part these practices developed in independence. As a result, the research directions, tools and motivations for each approach developed in relative isolation. The main objective of this project is to establish a network of collaborations between the experts of these diverse methods to investigate substructural logics in a cohesive fashion, taking into account these three distinct yet complementary points of view. The main momentum for this endeavour is provided by recent surprising results that confirm how deeply algebraic and proof theoretic methods are linked to one another. The proposal gathers leading experts in all these three areas, from all around the word, with the aim of reuniting these traditions and their communities and obtain deep results in all three areas. We are confident that this innovative, combined perspective on substructural logics will have a deep impact on the field and that this project will provide a stable basis of cooperation for a large, international community of algebraists, logicians and theoretical computer scientists, giving fresh impetus to these disciplines to flourish and integrate.
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP.2012.1.2-1 | Award Amount: 14.00M | Year: 2013
NANOREM is designed to unlock the potential of nanoremediation and so support both the appropriate use of nanotechnology in restoring land and aquifer resources and the development of the knowledge-based economy at a world leading level for the benefit of a wide range of users in the EU environmental sector. NANOREM uniquely takes a holistic approach to examining how the potential for nanoremediation can be developed and applied in practice, to enhance a stronger development of nanoremediation markets and applications in the EU. NANOREMs ambitious objectives are: 1) Identification of the most appropriate nanoremediation technological approaches to achieve a step change in practical remediation performance. Development of lower cost production techniques and production at commercially relevant scales, also for large scale applications. 2) Determination of the mobility and migration potential of nanoparticles in the subsurface, and their potential to cause harm, focusing on the NP types most likely to be adopted into practical use in the EU. 3) Development of a comprehensive tool box for field scale observation of nanoremediation performance and determination of the fate of NPs in the subsurface, including analytical methods, field measurement devices, decision support and numerical tools. 4) Dissemination and dialogue with key stakeholder interests to ensure that research, development and demonstration meets end-user and regulatory requirements and information and knowledge is shared widely across the EU. 5) Provide applications at representative scales including field sites to validate cost, performance, and fate and transport findings. The NANOREM consortium is multidisciplinary, cross-sectoral and transnational. It includes 28 partners from 12 countries organized in 11 work packages. The consortium includes 18 of the leading nanoremediation research groups in the EU, 10 industry and service providers (8 SMEs) and one organisation with policy and regulatory interest.
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.9.1 | Award Amount: 2.39M | Year: 2012
Quantum information technology (QIT) offers faster processing and more secure transfer of information based on the laws of quantum mechanics. It is a vital technology of the future as conventional methods reach their limits. Current QIT operates with microscopic objects: single atoms, ions, molecules, and especially photons. Few-photon states of light are used in commercial quantum key distribution (QKD) systems. However, as single photons do not have efficient non-destructive interactions with each other or with material objects, their usefulness is limited. It is tempting to extend QIT protocols to macroscopic states of light, enabling more efficient interactions, but it is widely believed that going to macroscopic scale degrades quantum features. In particular, squeezed coherent states of light contain classical excitation as their largest part and are therefore inapplicable in most QIT protocols.We challenge the accepted viewpoint that only few-photon states provide the optimal features required in QIT. Unlike squeezed coherent states, bright squeezed vacuum (BSV) has perfect photon-number correlations. It thus resembles two-photon entangled states but has macroscopic photon numbers. The 5 complementary teams of our consortium plan to perform proof-of-principle experiments and calculations showing that BSV can (1) manifest experimentally accessible non-separability; (2) violate Bell inequalities, including new ones, specific for such states, and thus manifest new non-classical correlations; (3) be prepared in a single Schmidt mode; (4) be used in QKD and (5) have new applications in quantum imaging. Achieving these results will foster QIT development in a new direction.Since BSV is macroscopic, it can be controlled by tapping a small portion and using almost non-invasive feedforward techniques. In QKD protocols based on entanglement this could result in practical device-independent schemes, as the macroscopic nature would remove the detection loophole problem.
Univerzita Palackeho V Olomouci | Date: 2016-06-22
The present invention relates to a paper-based composite planar material, which contains cellulose fibers and filler particles, selected from kaolin, kaolinite, TiO_(2), Al_(2)O_(3) and mixtures thereof, of sizes in the range of from 50 nm to 200 m, whereas the filler particles content is in the range of from 5 to 65 % (w/w). It relates also to a packaging material for microwave applications, which contains the composite material according to the present invention. Furthermore, a method of preparation of the composite material is disclosed, as well as its uses.
Agency: European Commission | Branch: H2020 | Program: ERC-COG | Phase: ERC-CoG-2015 | Award Amount: 1.83M | Year: 2016
The suite of graphenes unique properties and applications can be enormously enhanced by its functionalization. As non-covalently functionalized graphenes do not target all graphenes properties and may suffer from limited stability, covalent functionalization represents a promising way for controlling graphenes properties. To date, only a few well-defined graphene derivatives have been introduced. Among them, fluorographene (FG) stands out as a prominent member because of its easy synthesis and high stability. Being a perfluorinated hydrocarbon, FG was believed to be as unreactive as the two-dimensional counterpart perfluoropolyethylene (Teflon). However, our recent experiments showed that FG is not chemically inert and can be used as a viable precursor for synthesizing graphene derivatives. This surprising behavior indicates that common textbook grade knowledge cannot blindly be applied to the chemistry of 2D materials. Further, there might be specific rules behind the chemistry of 2D materials, forming a new chemical discipline we tentatively call 2D chemistry. The main aim of the project is to explore, identify and apply the rules of 2D chemistry starting from FG. Using the knowledge gained of 2D chemistry, we will attempt to control the chemistry of various 2D materials aimed at preparing stable graphene derivatives with designed properties, e.g., 1-3 eV band gap, fluorescent properties, sustainable magnetic ordering and dispersability in polar media. The new graphene derivatives will be applied in sensing, imaging, magnetic delivery and catalysis and new emerging applications arising from the synergistic phenomena are expected. We envisage that new applications will be opened up that benefit from the 2D scaffold and tailored properties of the synthesized derivatives. The derivatives will be used for the synthesis of 3D hybrid materials by covalent linking of the 2D sheets joined with other organic and inorganic molecules, nanomaterials or biomacromolecules.