University uvergne

Clermont-Ferrand, France

University uvergne

Clermont-Ferrand, France
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Bartoli A.,University uvergne | Ozgur E.,University uvergne
Adjunct Proceedings of the 2016 IEEE International Symposium on Mixed and Augmented Reality, ISMAR-Adjunct 2016 | Year: 2016

Shape-from-Template (SfT) uses an object's shape template and a deformation law to achieve single-image reconstruction. SfT is a fundamental tool to retexture or augment a deformable object in a monocular video. It has matured for isometric deformations, but the non-isometric case is yet largely open. This is because modeling is generally more complicated and the constraints certainly weaker. Existing algorithms use, for instance, linear elasticity, require one to provide boundary conditions represented by known deformed shape parts and need nonconvex optimization. We use a very simple and generic model to show that non-isometric SfT has a unique solution up to scale under strong perspective imaging and mild deformation curvature. Our model uses a novel type of homography interpretation that we call Perspective-Projection-Affine-Embedding. It may use boundary conditions if available and can be estimated with Linear Least Squares optimization. We provide experimental results on synthetic and real data. © 2016 IEEE.

Gasc C.,University of Auvergne | Constantin A.,University uvergne | Jaziri F.,University uvergne | Peyret P.,University of Auvergne
Database | Year: 2017

The detection and identification of bacterial pathogens involved in acts of bio- and agroterrorism are essential to avoid pathogen dispersal in the environment and propagation within the population. Conventional molecular methods, such as PCR amplification, DNA microarrays or shotgun sequencing, are subject to various limitations when assessing environmental samples, which can lead to inaccurate findings. We developed a hybridization capture strategy that uses a set of oligonucleotide probes to target and enrich biomarkers of interest in environmental samples. Here, we present Oligonucleotide Capture Probes for Pathogen Identification Database (OCaPPI-Db), an online capture probe database containing a set of 1, 685 oligonucleotide probes allowing for the detection and identification of 30 biothreat agents up to the species level. This probe set can be used in its entirety as a comprehensive diagnostic tool or can be restricted to a set of probes targeting a specific pathogen or virulence factor according to the user's needs. © The Author(s) 2017. Published by Oxford University Press.

Caberlotto E.,Institute Pasteur Paris | Caberlotto E.,French Institute of Health and Medical Research | Caberlotto E.,University Pierre and Marie Curie | Michel V.,Institute Pasteur Paris | And 38 more authors.
Proceedings of the National Academy of Sciences of the United States of America | Year: 2011

The mechanotransducer channels of auditory hair cells are gated by tip-links, oblique filaments that interconnect the stereocilia of the hair bundle. Tip-links stretch from the tips of stereocilia in the short and middle rows to the sides of neighboring, taller stereocilia. They are made of cadherin-23 and protocadherin-15, products of the Usher syndrome type 1 genes USH1D and USH1F, respectively. In this study we address the role of sans, a putative scaffold protein and product of the USH1G gene. In Ush1g-/- mice, the cohesion of stereocilia is disrupted, and both the amplitude and the sensitivity of the transduction currents are reduced. In Ush1g fl/flMyo15-cre+/- mice, the loss of sans occurs postnatally and the stereocilia remain cohesive. In these mice, there is a decrease in the amplitude of the total transducer current with no loss in sensitivity, and the tips of the stereocilia in the short and middle rows lose their prolate shape, features that can be attributed to the loss of tip-links. Furthermore, stereocilia from these rows undergo a dramatic reduction in length, suggesting that the mechanotransduction machinery has a positive effect on F-actin polymerization. Sans interacts with the cytoplasmic domains of cadherin-23 and protocadherin-15 in vitro and is absent from the hair bundle in mice defective for either of the two cadherins. Because sans localizes mainly to the tips of short- and middle-row stereocilia in vivo, we conclude that it belongs to a molecular complex at the lower end of the tip-link and plays a critical role in the maintenance of this link.

Lobaccaro J.M.A.,University Blaise Pascal | Lobaccaro J.M.A.,French National Center for Scientific Research | Lobaccaro J.M.A.,French Institute of Health and Medical Research | Gallot D.,Estaing University Hospital Center | And 3 more authors.
Journal of Endocrinological Investigation | Year: 2013

The role of cholesterol in female reproductive physiology has been suspected for a long time, while the molecular bases were unknown. Cholesterol is the precursor of ovarian steroid biosynthesis and is also essential for fertility. In the uterus, cholesterol is essential to achieve correct contractions at term, but an excessive uterine cholesterol concentration has been associated with contractility defects. Liver X Receptor (LXR) α and LXR β are nuclear receptors activated by oxysterols, oxidized derivatives of cholesterol. Since their discovery, the role of LXR in the control of cholesterol homeostasis has been widely described. Beyond their cholesterol-lowering role, more recent data have linked these nuclear receptors to various physiological processes. In particular, they control ovarian endocrine and exocrine functions, as well as uterine contractility. Their contribution to female reproductive cancers will also be discussed. This review will try to enlighten on the LXR as a molecular link between dietary cholesterol and reproductive diseases in women. In the future, a better comprehension of the various physiological processes regulated by the LXR will help to develop new ligands to prevent or to cure these pathologies in women. © 2013, Editrice Kurtis.

Garay R.P.,University Paris - Sud | Citrome L.,New York Medical College | Samalin L.,University uvergne | Liu C.-C.,National Taiwan University Hospital | And 4 more authors.
Expert Opinion on Pharmacotherapy | Year: 2016

Introduction: In this review, the authors describe medications in phase III of clinical development for schizophrenia and schizoaffective disorder, and provide an opinion on how current treatment can be improved in the near future.Areas covered: Recent (post 2013) phase III clinical trials of schizophrenia-targeted therapies were found in US and EU clinical trial registries. Two hundred fifty-three trials were identified, that included 16 investigational compounds. The antipsychotics brexpiprazole and cariprazine have been approved in the US, and although both are dopamine D2 receptor partial agonists, they differ markedly in their pharmacodynamic profiles. Encenicline and valbenazine are first-in-class candidates for treatment of cognitive impairment associated with schizophrenia (CIAS) and tardive dyskinesia, respectively. Eleven add-on compounds were previously approved for other therapeutic indications and are for the most part being studied at academic medical centers and smaller pharmaceutical companies for negative symptoms and CIAS or for specific populations (comorbidities, antipsychotic-induced obesity).Expert opinion: Promising new agents are emerging for schizophrenia and schizoaffective disorder. In addition to better-tolerated antipsychotics that treat positive symptoms, we could see the arrival of the first effective drug for negative symptoms and CIAS, which would strongly facilitate the ultimate goal of recovery in persons with schizophrenia. © 2016 Informa UK Limited.

Jimenez Cabello D.,University of Alcalá | Behnke S.,University of Bonn | Perez D.P.,University uvergne
VISAPP 2013 - Proceedings of the International Conference on Computer Vision Theory and Applications | Year: 2013

Detecting primitives, like lines and planes, is a popular first step for the interpretation of range images. Real scenes are, however, often cluttered and range measurements are noisy, such that the detection of pure lines and planes is unreliable. In this paper, we propose a new primitive that combines properties of planes and lines: Linear Plane Borders (LPB). These are planar stripes of a certain width that are delineated at one side by a linear edge (i.e. depth discontinuity). The design of this primitive is motivated by the contours of many man-made objects. We extend the J-Linkage algorithm to robustly detect multiple LPBs in range images from noisy sensors. We validated our method using qualitative and quantitative experiments with real scenes.

Destrez R.,Laboratoire PRISME | Treuillet S.,Laboratoire PRISME | Lucas Y.,Laboratoire PRISME | Albouy-Kissi B.,University uvergne
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2013

In orthodontics, a common practice used to diagnose and plan the treatment is the dental cast. After digitization by a CTscan or a laser scanner, the obtained 3D surface models can feed orthodontics numerical tools for computer-aided diagnosis and treatment planning. One of the pre-processing critical steps is the 3D registration of dental arches to obtain the occlusion of these numerical models. For this task, we propose a vision based method to automatically compute the registration based on photos of patient mouth. From a set of matched singular points between two photos and the dental 3D models, the rigid transformation to apply to the mandible to be in contact with the maxillary may be computed by minimizing the reprojection errors. During a precedent study, we established the feasibility of this visual registration approach with a manual selection of singular points. This paper addresses the issue of automatic point detection. Based on a priori knowledge, histogram thresholding and edge detection are used to extract specific points in 2D images. Concurrently, curvatures information detects 3D corresponding points. To improve the quality of the final registration, we also introduce a combined optimization of the projection matrix with the 2D/3D point positions. These new developments are evaluated on real data by considering the reprojection errors and the deviation angles after registration in respect to the manual reference occlusion realized by a specialist. © 2013 SPIE.

Lenoir L.,University uvergne | Rossary A.,Clermont University | Joubert-Zakeyh J.,Service DAnatomie et de Cytologie Pathologiques | Vergnaud-Gauduchon J.,Clermont University | And 6 more authors.
Digestive Diseases and Sciences | Year: 2011

Background Inflammatory bowel diseases (IBD) consist of an uncontrolled intestinal inflammation leading to mucosal disruption. This inflammation is accompanied by an excessive production of reactive oxygen species (ROS). Polyphenols are micronutrients with antioxidative and antiinflammatory properties, and may play an interesting role in the prevention of intestinal inflammation. Lemon verbena (Aloysia triphylla) infusion is a popular herbal infusion rich in polyphenols (flavones and verbascoside). Aims This study evaluated the preventive effects of lemon verbena infusion consumption against mild-tomoderate dextran sulfate sodium (DSS)-induced colitis in rats. Methods Wistar rats drank water or lemon verbena infusion for 14 days. On day 15, half of the rats received DSS (4%) in their drink for 7 days. At the end of the experimental period, the colon was taken for histopathological examination and determination of myeloperoxidase (MPO) activity, antioxidant enzyme activities (superoxide dismutase [SOD], glutathione peroxidase [GPx], glutathione reductase [GR], catalase [CAT]), glutathione and lipid peroxidation. Lymphocyte populations were determined in blood, mesenteric nodes and Peyer's patches. Results Rats ingested daily 5.6 μmol of polyphenols. DSS reduced food intake and induced colitis, as reflected by histological lesions and increased MPO activity. Although these alterations were not significantly counteracted by lemon verbena consumption, the herbal infusion increased colonic SOD activity and decreased lipid peroxidation (malondialdehyde). Other oxidative stress markers (GPx, GR, CAT, glutathione) were not significantly modified. Conclusion Our study shows that the preventive consumption of lemon verbena infusion offered some antioxidative protection during experimental colitis by stimulating SOD activity and decreasing lipid peroxidation. © Springer Science+Business Media, LLC 2011.

Coudert P.,University uvergne | Donas E.,24 Avenue du General de Gaulle
Actualites Pharmaceutiques | Year: 2015

The most frequently found insect in domestic carnivores, the flea does not just produce skin disorders in its hosts. It can also be a vector of helminths such as tapeworms and heartworms in dogs, as well as bacteria in cats. The pharmacist is in a position to be able to advise pet owners. The eradication of fleas requires the use of active principles and galenic forms adapted to each animal as well as a specific treatment for the living areas. © 2015 Elsevier Masson SAS.

Braux-Zin J.,CEA Saclay Nuclear Research Center | Bartoli A.,University uvergne | Dupont R.,CEA Saclay Nuclear Research Center | Vinciguerra R.,CEA Saclay Nuclear Research Center
Proceedings - 2nd Joint 3DIM/3DPVT Conference: 3D Imaging, Modeling, Processing, Visualization and Transmission, 3DIMPVT 2012 | Year: 2012

We present a novel extrinsic calibration method for optical see-through systems. It is primarily aimed at tablet-like systems with a semi transparent screen, a camera tracking the user position and another camera analyzing the scene but easily generalizable to any optical see-through setup. Relative poses of the cameras and the screen are all needed for proper alignment. The proposed algorithm is based on the user indicating the projections onto the screen of several reference points chosen on a known object. A convex estimation is computed through the resectioning of virtual cameras and used to initialize a global bundle adjustment. Both synthetic and real experiments show the viability of our approach. © 2012 IEEE.

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