Lobaccaro J.M.A.,University Blaise Pascal |
Lobaccaro J.M.A.,French National Center for Scientific Research |
Lobaccaro J.M.A.,French Institute of Health and Medical Research |
Gallot D.,Estaing University Hospital Center |
And 3 more authors.
Journal of Endocrinological Investigation | Year: 2013
The role of cholesterol in female reproductive physiology has been suspected for a long time, while the molecular bases were unknown. Cholesterol is the precursor of ovarian steroid biosynthesis and is also essential for fertility. In the uterus, cholesterol is essential to achieve correct contractions at term, but an excessive uterine cholesterol concentration has been associated with contractility defects. Liver X Receptor (LXR) α and LXR β are nuclear receptors activated by oxysterols, oxidized derivatives of cholesterol. Since their discovery, the role of LXR in the control of cholesterol homeostasis has been widely described. Beyond their cholesterol-lowering role, more recent data have linked these nuclear receptors to various physiological processes. In particular, they control ovarian endocrine and exocrine functions, as well as uterine contractility. Their contribution to female reproductive cancers will also be discussed. This review will try to enlighten on the LXR as a molecular link between dietary cholesterol and reproductive diseases in women. In the future, a better comprehension of the various physiological processes regulated by the LXR will help to develop new ligands to prevent or to cure these pathologies in women. © 2013, Editrice Kurtis.
Antenatal management for patients with increased risk of post-partum hemorrhage (excluding abnormal placentatio [Prise en charge anténatale des patientes à risque d'hémorragie du post-partum (hors anomalies de l'insertion placentaire)]
Fournet-Fayard A.,Estaing University Hospital Center |
Lebreton A.,Estaing University Hospital Center |
Ruivard M.,Estaing University Hospital Center |
Ruivard M.,University uvergne |
And 6 more authors.
Journal de Gynecologie Obstetrique et Biologie de la Reproduction | Year: 2014
Objectives-To describe management and screening for high-risk patients concerning post-partum hemorrhage (PPH) and antenatal management for severe anemia, thrombopenia,bleeding disorders and anticoagulant therapy.Methods -Bibliographic search restricted to French and English languages using Medline data-base and recommendations of medical societies.Results -The appropriate place for delivery should be chosen after multidisciplinary concer-tation based on level of risk (especially past-history of severe PPH and bleeding disorder) andeasy access to blood products (Professional Consensus). Prevention for severe anemia is mainlybased on oral iron supplementation (grade B). Explorations are required in case of thrombope-nia < 100 Giga/L (grade C). Patients with bleeding disorder require the assistance of a physicianskilled in hemostasis for perinatal management (grade C). Preventive anticoagulant therapyhas no impact on PPH risk and perimedullar analgesia is usually authorized 12 hours after lastinjection (grade C). Curative anticoagulant therapy slightly increases PPH risk and perimedullaranalgesia is authorized only after 24 hours since last injection (Professional Consensus).Conclusion -Prenatal identification of high-risk patients concerning PPH implies multidiscipli-nary concertation to determine the most appropriate birthplace where technical and humanresources are available. © 2014 Elsevier Masson SAS. All rights reserved.
Therapeutic improvements expected in the near future for schizophrenia and schizoaffective disorder: An appraisal of phase III clinical trials of schizophrenia-targeted therapies as found in US and EU clinical trial registries
Garay R.P.,University Paris - Sud |
Citrome L.,New York Medical College |
Samalin L.,University uvergne |
Liu C.-C.,National Taiwan University Hospital |
And 4 more authors.
Expert Opinion on Pharmacotherapy | Year: 2016
Introduction: In this review, the authors describe medications in phase III of clinical development for schizophrenia and schizoaffective disorder, and provide an opinion on how current treatment can be improved in the near future.Areas covered: Recent (post 2013) phase III clinical trials of schizophrenia-targeted therapies were found in US and EU clinical trial registries. Two hundred fifty-three trials were identified, that included 16 investigational compounds. The antipsychotics brexpiprazole and cariprazine have been approved in the US, and although both are dopamine D2 receptor partial agonists, they differ markedly in their pharmacodynamic profiles. Encenicline and valbenazine are first-in-class candidates for treatment of cognitive impairment associated with schizophrenia (CIAS) and tardive dyskinesia, respectively. Eleven add-on compounds were previously approved for other therapeutic indications and are for the most part being studied at academic medical centers and smaller pharmaceutical companies for negative symptoms and CIAS or for specific populations (comorbidities, antipsychotic-induced obesity).Expert opinion: Promising new agents are emerging for schizophrenia and schizoaffective disorder. In addition to better-tolerated antipsychotics that treat positive symptoms, we could see the arrival of the first effective drug for negative symptoms and CIAS, which would strongly facilitate the ultimate goal of recovery in persons with schizophrenia. © 2016 Informa UK Limited.
Jimenez Cabello D.,University of Alcalá |
Behnke S.,University of Bonn |
Perez D.P.,University uvergne
VISAPP 2013 - Proceedings of the International Conference on Computer Vision Theory and Applications | Year: 2013
Detecting primitives, like lines and planes, is a popular first step for the interpretation of range images. Real scenes are, however, often cluttered and range measurements are noisy, such that the detection of pure lines and planes is unreliable. In this paper, we propose a new primitive that combines properties of planes and lines: Linear Plane Borders (LPB). These are planar stripes of a certain width that are delineated at one side by a linear edge (i.e. depth discontinuity). The design of this primitive is motivated by the contours of many man-made objects. We extend the J-Linkage algorithm to robustly detect multiple LPBs in range images from noisy sensors. We validated our method using qualitative and quantitative experiments with real scenes.
Characteristics of practitioners prescribing glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors [Profil des medecins prescripteurs des agonistes du recepteur du GLP-1 ou des inhibiteurs de la DPP4]
Bogenmann L.,Center Hospitalier University |
Vidal P.,Direction Regionale du Service Medical DAuvergne |
Pereira B.,University uvergne |
Tauveron I.,Center Hospitalier University
Medecine des Maladies Metaboliques | Year: 2015
Many recommendations on antidiabetic treatments for type 2 diabetes are available. GLP-1 receptor agonists and DPP-4 inhibitors are now part of our therapeutic arsenal, but their prescription remains limited. In this context, we decided to conduct a study on the profile of the physicians prescribing these drugs in the French Auvergne region regarding the medical demography, their mode of exercise, or their training. The data are obtained by individualized telephone questionnaire and from the files of the national health insurance fund (Cnamts) for a period of one year. The target population is defined by the 1077 GPs practicing in one of the four departments of the Auvergne region as listed in the directory. Data for 546 GP's have been collected. The average age of included physicians is 52.7 years. The population is made up of 178 women and 368 men. Comparing the group of prescribers of GLP-1 receptor agonists and DPP-4 inhibitors ("incretins") to non-prescribers (health insurance data): age, practicing in a rural or urban area, group practice or medical house, and adherence to diabetes network or participation in CME on diabetes, have no influence over the choice of treatments. Prescribers of "incretins" are predominantly male, and perform more consultations and are more willing to receive pharmaceutical companies. These results are statistically significant. The choice of a medical prescription is a complex process and is discussed. However the influence of the pharmaceutical industry in the innovative molecules' prescribing is confirmed. © 2015-Elsevier Masson SAS-Tous droits reserves.
Destrez R.,Laboratoire PRISME |
Treuillet S.,Laboratoire PRISME |
Lucas Y.,Laboratoire PRISME |
Albouy-Kissi B.,University uvergne
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2013
In orthodontics, a common practice used to diagnose and plan the treatment is the dental cast. After digitization by a CTscan or a laser scanner, the obtained 3D surface models can feed orthodontics numerical tools for computer-aided diagnosis and treatment planning. One of the pre-processing critical steps is the 3D registration of dental arches to obtain the occlusion of these numerical models. For this task, we propose a vision based method to automatically compute the registration based on photos of patient mouth. From a set of matched singular points between two photos and the dental 3D models, the rigid transformation to apply to the mandible to be in contact with the maxillary may be computed by minimizing the reprojection errors. During a precedent study, we established the feasibility of this visual registration approach with a manual selection of singular points. This paper addresses the issue of automatic point detection. Based on a priori knowledge, histogram thresholding and edge detection are used to extract specific points in 2D images. Concurrently, curvatures information detects 3D corresponding points. To improve the quality of the final registration, we also introduce a combined optimization of the projection matrix with the 2D/3D point positions. These new developments are evaluated on real data by considering the reprojection errors and the deviation angles after registration in respect to the manual reference occlusion realized by a specialist. © 2013 SPIE.
Othman I.,University of Monastir |
Othman I.,University of Carthage |
Mirand A.,University uvergne |
Mirand A.,Center National Of Reference Des Enterovirus Parechovirus |
And 7 more authors.
PLoS ONE | Year: 2015
The enterovirus (EV) types echovirus (E-) 5, E-9, and E-18, and coxsackievirus (CV-) A9 are infrequently reported in human diseases and their epidemiologic features are poorly defined. Virus transmission patterns between countries have been estimated with phylogenetic data derived from the 1D/VP1 and 3CD gene sequences of a sample of 74 strains obtained in France (2000-2012) and Tunisia (2011-2013) and from the publicly available sequences. The EV types (E-5, E-9, and E-18) exhibited a lower worldwide genetic diversity (respective number of genogroups: 4, 5, and 3) in comparison to CV-A9 (n = 10). The phylogenetic trees estimated with both 1D/VP1 and 3CD sequence data showed variations in the number of co-circulating lineages over the last 20 years among the four EV types. Despite the low number of genogroups in E-18, the virus exhibited the highest number of recombinant 3CD lineages (n = 10) versus 4 (E-5) to 8 (E-9). The phylogenies provided evidence of multiple transportation events between France and Tunisia involving E-5, E-9, E-18, and CV-A9 strains. Virus spread events between France and 17 other countries in five continents had high probabilities of occurrence as those between Tunisia and two European countries other than France. All transportation events were supported by BF values > 10. Inferring the source of virus transmission from phylogenetic data may provide insights into the patterns of sporadic and epidemic diseases caused by EVs. © 2015 Othman et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Lenoir L.,University uvergne |
Rossary A.,Clermont University |
Joubert-Zakeyh J.,Service DAnatomie et de Cytologie Pathologiques |
Vergnaud-Gauduchon J.,Clermont University |
And 6 more authors.
Digestive Diseases and Sciences | Year: 2011
Background Inflammatory bowel diseases (IBD) consist of an uncontrolled intestinal inflammation leading to mucosal disruption. This inflammation is accompanied by an excessive production of reactive oxygen species (ROS). Polyphenols are micronutrients with antioxidative and antiinflammatory properties, and may play an interesting role in the prevention of intestinal inflammation. Lemon verbena (Aloysia triphylla) infusion is a popular herbal infusion rich in polyphenols (flavones and verbascoside). Aims This study evaluated the preventive effects of lemon verbena infusion consumption against mild-tomoderate dextran sulfate sodium (DSS)-induced colitis in rats. Methods Wistar rats drank water or lemon verbena infusion for 14 days. On day 15, half of the rats received DSS (4%) in their drink for 7 days. At the end of the experimental period, the colon was taken for histopathological examination and determination of myeloperoxidase (MPO) activity, antioxidant enzyme activities (superoxide dismutase [SOD], glutathione peroxidase [GPx], glutathione reductase [GR], catalase [CAT]), glutathione and lipid peroxidation. Lymphocyte populations were determined in blood, mesenteric nodes and Peyer's patches. Results Rats ingested daily 5.6 μmol of polyphenols. DSS reduced food intake and induced colitis, as reflected by histological lesions and increased MPO activity. Although these alterations were not significantly counteracted by lemon verbena consumption, the herbal infusion increased colonic SOD activity and decreased lipid peroxidation (malondialdehyde). Other oxidative stress markers (GPx, GR, CAT, glutathione) were not significantly modified. Conclusion Our study shows that the preventive consumption of lemon verbena infusion offered some antioxidative protection during experimental colitis by stimulating SOD activity and decreasing lipid peroxidation. © Springer Science+Business Media, LLC 2011.
Coudert P.,University uvergne |
Donas E.,24 Avenue du General de Gaulle
Actualites Pharmaceutiques | Year: 2015
The most frequently found insect in domestic carnivores, the flea does not just produce skin disorders in its hosts. It can also be a vector of helminths such as tapeworms and heartworms in dogs, as well as bacteria in cats. The pharmacist is in a position to be able to advise pet owners. The eradication of fleas requires the use of active principles and galenic forms adapted to each animal as well as a specific treatment for the living areas. © 2015 Elsevier Masson SAS.
Braux-Zin J.,CEA Saclay Nuclear Research Center |
Bartoli A.,University uvergne |
Dupont R.,CEA Saclay Nuclear Research Center |
Vinciguerra R.,CEA Saclay Nuclear Research Center
Proceedings - 2nd Joint 3DIM/3DPVT Conference: 3D Imaging, Modeling, Processing, Visualization and Transmission, 3DIMPVT 2012 | Year: 2012
We present a novel extrinsic calibration method for optical see-through systems. It is primarily aimed at tablet-like systems with a semi transparent screen, a camera tracking the user position and another camera analyzing the scene but easily generalizable to any optical see-through setup. Relative poses of the cameras and the screen are all needed for proper alignment. The proposed algorithm is based on the user indicating the projections onto the screen of several reference points chosen on a known object. A convex estimation is computed through the resectioning of virtual cameras and used to initialize a global bundle adjustment. Both synthetic and real experiments show the viability of our approach. © 2012 IEEE.