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Clermont-Ferrand, France

Lobaccaro J.M.A.,University Blaise Pascal | Lobaccaro J.M.A.,French National Center for Scientific Research | Lobaccaro J.M.A.,French Institute of Health and Medical Research | Gallot D.,Estaing University Hospital Center | And 3 more authors.
Journal of Endocrinological Investigation | Year: 2013

The role of cholesterol in female reproductive physiology has been suspected for a long time, while the molecular bases were unknown. Cholesterol is the precursor of ovarian steroid biosynthesis and is also essential for fertility. In the uterus, cholesterol is essential to achieve correct contractions at term, but an excessive uterine cholesterol concentration has been associated with contractility defects. Liver X Receptor (LXR) α and LXR β are nuclear receptors activated by oxysterols, oxidized derivatives of cholesterol. Since their discovery, the role of LXR in the control of cholesterol homeostasis has been widely described. Beyond their cholesterol-lowering role, more recent data have linked these nuclear receptors to various physiological processes. In particular, they control ovarian endocrine and exocrine functions, as well as uterine contractility. Their contribution to female reproductive cancers will also be discussed. This review will try to enlighten on the LXR as a molecular link between dietary cholesterol and reproductive diseases in women. In the future, a better comprehension of the various physiological processes regulated by the LXR will help to develop new ligands to prevent or to cure these pathologies in women. © 2013, Editrice Kurtis. Source

Bogenmann L.,Center Hospitalier University | Vidal P.,Direction Regionale du Service Medical DAuvergne | Pereira B.,University uvergne | Tauveron I.,Center Hospitalier University
Medecine des Maladies Metaboliques | Year: 2015

Many recommendations on antidiabetic treatments for type 2 diabetes are available. GLP-1 receptor agonists and DPP-4 inhibitors are now part of our therapeutic arsenal, but their prescription remains limited. In this context, we decided to conduct a study on the profile of the physicians prescribing these drugs in the French Auvergne region regarding the medical demography, their mode of exercise, or their training. The data are obtained by individualized telephone questionnaire and from the files of the national health insurance fund (Cnamts) for a period of one year. The target population is defined by the 1077 GPs practicing in one of the four departments of the Auvergne region as listed in the directory. Data for 546 GP's have been collected. The average age of included physicians is 52.7 years. The population is made up of 178 women and 368 men. Comparing the group of prescribers of GLP-1 receptor agonists and DPP-4 inhibitors ("incretins") to non-prescribers (health insurance data): age, practicing in a rural or urban area, group practice or medical house, and adherence to diabetes network or participation in CME on diabetes, have no influence over the choice of treatments. Prescribers of "incretins" are predominantly male, and perform more consultations and are more willing to receive pharmaceutical companies. These results are statistically significant. The choice of a medical prescription is a complex process and is discussed. However the influence of the pharmaceutical industry in the innovative molecules' prescribing is confirmed. © 2015-Elsevier Masson SAS-Tous droits reserves. Source

Destrez R.,Laboratoire PRISME | Treuillet S.,Laboratoire PRISME | Lucas Y.,Laboratoire PRISME | Albouy-Kissi B.,University uvergne
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2013

In orthodontics, a common practice used to diagnose and plan the treatment is the dental cast. After digitization by a CTscan or a laser scanner, the obtained 3D surface models can feed orthodontics numerical tools for computer-aided diagnosis and treatment planning. One of the pre-processing critical steps is the 3D registration of dental arches to obtain the occlusion of these numerical models. For this task, we propose a vision based method to automatically compute the registration based on photos of patient mouth. From a set of matched singular points between two photos and the dental 3D models, the rigid transformation to apply to the mandible to be in contact with the maxillary may be computed by minimizing the reprojection errors. During a precedent study, we established the feasibility of this visual registration approach with a manual selection of singular points. This paper addresses the issue of automatic point detection. Based on a priori knowledge, histogram thresholding and edge detection are used to extract specific points in 2D images. Concurrently, curvatures information detects 3D corresponding points. To improve the quality of the final registration, we also introduce a combined optimization of the projection matrix with the 2D/3D point positions. These new developments are evaluated on real data by considering the reprojection errors and the deviation angles after registration in respect to the manual reference occlusion realized by a specialist. © 2013 SPIE. Source

Jimenez Cabello D.,University of Alcala | Behnke S.,University of Bonn | Perez D.P.,University uvergne
VISAPP 2013 - Proceedings of the International Conference on Computer Vision Theory and Applications | Year: 2013

Detecting primitives, like lines and planes, is a popular first step for the interpretation of range images. Real scenes are, however, often cluttered and range measurements are noisy, such that the detection of pure lines and planes is unreliable. In this paper, we propose a new primitive that combines properties of planes and lines: Linear Plane Borders (LPB). These are planar stripes of a certain width that are delineated at one side by a linear edge (i.e. depth discontinuity). The design of this primitive is motivated by the contours of many man-made objects. We extend the J-Linkage algorithm to robustly detect multiple LPBs in range images from noisy sensors. We validated our method using qualitative and quantitative experiments with real scenes. Source

Coudert P.,University uvergne | Donas E.,24 avenue du General De Gaulle
Actualites Pharmaceutiques | Year: 2015

The most frequently found insect in domestic carnivores, the flea does not just produce skin disorders in its hosts. It can also be a vector of helminths such as tapeworms and heartworms in dogs, as well as bacteria in cats. The pharmacist is in a position to be able to advise pet owners. The eradication of fleas requires the use of active principles and galenic forms adapted to each animal as well as a specific treatment for the living areas. © 2015 Elsevier Masson SAS. Source

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