News Article | February 15, 2017
Attorney Lloyd Herman, founder of Lloyd Herman & Associates, is celebrating his fiftieth anniversary as a legal professional. “It’s been a pleasure to be able to help injured victims take on a system that is stacked against them and bring them favorable outcomes against heavy odds,” said Herman. “Fifty years of being able to do this is very satisfying from a personal and professional standpoint. Being able to add value to human beings through legal, psychological and moral support has been extremely gratifying.” Herman received his Juris Doctor from Gonzaga University School of Law in Spokane, WA, in 1966. He worked in several different areas until he found his niche thirty years ago doing personal injury claims. Since then Herman has settled approximately 1,500 cases, of which he has made case law on a couple. Herman is renowned for settling almost all of his cases out of court. “Just in the sixteen years I have been here, I have gone to trial less than ten times,” added Herman, who devotes 90 percent of his practice to the area of litigation. During the course of his illustrious career, Herman has been instrumental in changing the law in Washington state in favor of consumers in the Supreme Court and Division III in the Court of Appeals, which had the effect of aiding people against bad faith acts of the insurance companies. He also helped expand the law in the area of automobile coverage and in favor of tenants of defective apartment houses and rentals. About Lloyd Herman, Lloyd Herman & Associates Attorney Lloyd Herman is licensed to practice before the Western and Eastern Federal District Court and the Ninth Circuit Court of Appeals, including Eastern Washington and Northern Idaho. He focuses his practice on personal injury law, workers’ compensation law and wills and trusts. For more information, please call (509) 922-6600, or visit http://www.lloydhermanlaw.com. The law office is located at 213 N. University Road, Spokane, WA 99206. About the NALA™ The NALA offers small and medium-sized businesses effective ways to reach customers through new media. As a single-agency source, the NALA helps businesses flourish in their local community. The NALA’s mission is to promote a business’ relevant and newsworthy events and achievements, both online and through traditional media. For media inquiries, please call 805.650.6121, ext. 361.
Crowley P.B.,University Road |
Chow E.,University College Dublin |
Papkovskaia T.,University College Dublin
ChemBioChem | Year: 2011
Protein science is shifting towards experiments performed under native or native-like conditions. In-cell NMR spectroscopy for instance has the potential to reveal protein structure and dynamics inside cells. However, not all proteins can be studied by this technique. 15N-labelled cytochrome c (cyt c) over-expressed in Escherichia coli was undetectable by in-cell NMR spectroscopy. When whole-cell lysates were subjected to size-exclusion chromatography (SEC) cyt c was found to elute with an apparent molecular weight of >150 kDa. The presence of high molecular weight species is indicative of complex formation between cyt c and E. coli cytosolic proteins. These interactions were disrupted by charge-inverted mutants in cyt c and by elevated concentrations of NaCl. The physiologically relevant salt, KGlu, was less efficient at disrupting complex formation. Notably, a triple mutant of cyt c could be detected in cell lysates by NMR spectroscopy. The protein, GB1, yields high quality in-cell spectra and SEC analysis of lysates containing GB1 revealed a lack of interaction between GB1 and E. coli proteins. Together these data suggest that protein "stickiness" is a limiting factor in the application of in-cell NMR spectroscopy. Electrostatic interactions in the cytosol: Size-exclusion chromatography was used to demonstrate binding between cytochrome c and E. coli cytosolic proteins. High concentrations of NaCl disrupted complex formation, but the physiologically relevant salt KGlu was less effective. Charge-inverted mutants also disrupted the interaction. In contrast to the wild-type protein, a triple mutant could be detected in cell lysates by NMR spectroscopy. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Lai C.-M.,National Cheng Kung University |
Lai C.-M.,University Road |
Hokoi S.,Kyoto University
Energy and Buildings | Year: 2014
This study combined building construction practice, microencapsulated phase change materials (mPCM), and aluminum honeycomb structures to construct an mPCM honeycomb wallboard prototype. The heat transfer characteristics and thermal storage behaviors of this prototype and other modules (mPCM only, mPCM + EG, and mPCM + iron-wire) were investigated experimentally. The results indicated that the aluminum honeycomb used for structural support and enhancing the thermal conductivity in the prototype rapidly transferred the heat flux into the mPCM. Consequently, the latent heat can be used to increase the time lag of the peak load, effectively shifting the peak hours of electricity use in the summer and achieving a lower module surface temperature than other modules. Thus, the mPCM + honeycomb exhibited better control over the surface temperature, which makes it suitable for use in places where the exterior surface temperature must be controlled. A correlation of the effective thermal protection duration of the mPCM + honeycomb modules for Ste5 = 2-5 and Sc1 = 0.24-0.32 was proposed. © 2014 Elsevier B.V.All rights reserved.
Griffin M.D.,National University of Ireland |
Elliman S.J.,University Road |
Cahill E.,National University of Ireland, Maynooth |
English K.,National University of Ireland, Maynooth |
And 2 more authors.
Stem Cells | Year: 2013
Mesenchymal stromal (stem) cells (MSCs) continue to be a strong area of focus for academic- and industry-based researchers who share the goal of expanding their therapeutic use for diverse inflammatory and immune-mediated diseases. Recently, there has been an accelerated rate of scientific publication, clinical trial activity, and commercialisation in the field. This has included the reporting of exciting new developments in four areas that will be of key importance to future successful use of MSC-based therapies in large numbers of patients: (a) fundamental biology of the primary cells in bone marrow and other tissues that give rise to MSCs in culture. (b) Mechanisms by which MSCs modulate immune and inflammatory responses in vivo. (c) Insights into MSC kinetics, safety, and efficacy in relevant animal disease models. (d) Isolation, definition, and clinical trial-based testing of human MSCs by biomedical companies and academic medical centers. Despite this progress, it remains unclear whether MSCs will enter mainstream therapeutic practice as a frequently used alternative to pharmacotherapy or surgical/radiological procedures in the foreseeable future. In this review, we summarize some of the most significant new developments for each of the four areas that contribute to the process of translating MSC research to the clinical arena. In the context of this recent progress, we discuss key challenges and specific knowledge gaps which, if not addressed in a coordinated fashion, may hinder the creation of robust "translational pipelines" for consolidating the status of MSC-based therapies. © AlphaMed Press.
Westbrook C.K.,Lawrence Livermore National Laboratory |
Pitz W.J.,Lawrence Livermore National Laboratory |
Mehl M.,Lawrence Livermore National Laboratory |
Curran H.J.,University Road
Proceedings of the Combustion Institute | Year: 2011
A detailed chemical kinetic reaction mechanism is developed for primary reference fuel mixtures of n-hexadecane and 2,2,4,4,6,8,8-heptamethyl nonane for diesel cetane ratings. The mechanisms are constructed using existing rules for reaction pathways and rate expressions developed previously for the primary reference fuels for gasoline octane ratings, n-heptane and iso-octane. These reaction mechanisms are validated by comparisons between computed and experimental results for shock tube ignition and for oxidation under jet-stirred reactor conditions. The combined kinetic reaction mechanism contains the submechanisms for the primary reference fuels for diesel cetane ratings and submechanisms for the primary reference fuels for gasoline octane ratings, all in one integrated large kinetic reaction mechanism. Representative applications of this mechanism to several test problems are presented, describing fuel/air autoignition variations with changes in fuel cetane and octane numbers, and others describing fuel combustion in a jet-stirred reactor environment with the fuel varying from pure 2,2,4,4,6,8,8-heptamethyl nonane (cetane number of 15) to pure n-hexadecane (cetane number of 100). © 2010 Published by Elsevier Inc. on behalf of The Combustion Institute. All rights reserved.
Watson L.,University Road |
Elliman S.J.,University Road |
Coleman C.M.,National University of Ireland
Stem Cell Research and Therapy | Year: 2014
Compromised bone-regenerating capability following a long bone fracture is often the result of reduced host bone marrow (BM) progenitor cell numbers and efficacy. Without surgical intervention, these malunions result in mobility restrictions, deformities, and disability. The clinical application of BM-derived mesenchymal stem cells (MSCs) is a feasible, minimally invasive therapeutic option to treat non-union fractures. This review focuses on novel, newly identified cell surface markers in both the mouse and human enabling the isolation and purification of osteogenic progenitor cells as well as their direct and indirect contributions to fracture repair upon administration. Furthermore, clinical success to date is summarized with commentary on autologous versus allogeneic cell sources and the methodology of cell administration. Given our clinical success to date in combination with recent advances in the identification, isolation, and mechanism of action of MSCs, there is a significant opportunity to develop improved technologies for defining therapeutic MSCs and potential to critically inform future clinical strategies for MSC-based bone regeneration. © 2014 Watson et al.; licensee BioMed Central Ltd.
Danaher J.,University Road
Science and Engineering Ethics | Year: 2016
Suppose we are about to enter an era of increasing technological unemployment. What implications does this have for society? Two distinct ethical/social issues would seem to arise. The first is one of distributive justice: how will the (presumed) efficiency gains from automated labour be distributed through society? The second is one of personal fulfillment and meaning: if people no longer have to work, what will they do with their lives? In this article, I set aside the first issue and focus on the second. In doing so, I make three arguments. First, I argue that there are good reasons to embrace non-work and that these reasons become more compelling in an era of technological unemployment. Second, I argue that the technological advances that make widespread technological unemployment possible could still threaten or undermine human flourishing and meaning, especially if (as is to be expected) they do not remain confined to the economic sphere. And third, I argue that this threat could be contained if we adopt an integrative approach to our relationship with technology. In advancing these arguments, I draw on three distinct literatures: (1) the literature on technological unemployment and workplace automation; (2) the antiwork critique—which I argue gives reasons to embrace technological unemployment; and (3) the philosophical debate about the conditions for meaning in life—which I argue gives reasons for concern. © 2016 Springer Science+Business Media Dordrecht
Baliga M.S.,Father Muller Medical College |
Kurian P.J.,University Road
Chinese Journal of Integrative Medicine | Year: 2012
Ixora coccinea Linn., (Rubiaceae) commonly known as jungle of geranium and red ixora, is an evergreen shrub found throughout India. Depending on the medical condition, the flowers, leaves, roots, and the stem are used to treat various ailments in the Indian traditional system of medicine, the Ayurveda, and also in various folk medicines. The fruits, when fully ripe, are used as a dietary source. Phytochemical studies indicate that the plant contains important phytochemicals such as lupeol, ursolic acid, oleanolic acid, sitosterol, rutin, lecocyanadin, anthocyanins, proanthocyanidins, glycosides of kaempferol and quercetin. Pharmacological studies suggest that the plant possesses antioxidative, antibacterial, gastroprotective, hepatoprotective, antidiarrhoeal, antinociceptive, antimutagenic, antineoplastic and chemopreventive effects, thus lending scientific support to the plant's ethnomedicinal uses. In the present review, efforts are made in addressing its ethnomedicinal uses, chemical constituents, and validated pharmacological observations. © 2011 Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg.
Quondamatteo F.,University Road
Cell and Tissue Research | Year: 2014
Diabetes mellitus (DM) is becoming increasingly prevalent worldwide. Although major complications of this condition involve kidney, retina and peripheral nerves, the skin of diabetic patients is also frequently injured. Hence, interest is mounting in the definition of the structural and molecular profile of non-complicated diabetic skin, i.e., before injuries occur. Most of the available knowledge in this area has been obtained relatively recently and, in part, derives from various diabetic animal models. These include both insulin-dependent and insulin-resistant models. Structural work in human diabetic skin has also been carried out by means of tissue samples or of non-invasive methods. Indications have indeed been found for molecular/structural changes in diabetic skin. However, the overall picture that emerges is heterogeneous, incomplete and often contradictory and many questions remain unanswered. This review aims to detail, as much as possible, the various pieces of current knowledge in a systematic and synoptic manner. This should aid the identification of areas in which key questions are still open and more research is needed. A comprehensive understanding of this field could help in determining molecular targets for the prevention and treatment of skin injuries in DM and markers for the monitoring of cutaneous and systemic aspects of the disease. Additionally, with the increasing development of non-invasive optics-based deep-tissue-imaging diagnostic technologies, precise knowledge of cutaneous texture and molecular structure becomes an important pre-requisite for the use of such methods in diabetic patients. © 2013 Springer-Verlag Berlin Heidelberg.
Danaher J.,University Road
Neuroethics | Year: 2016
Technology could be used to improve morality but it could do so in different ways. Some technologies could augment and enhance moral behaviour externally by using external cues and signals to push and pull us towards morally appropriate behaviours. Other technologies could enhance moral behaviour internally by directly altering the way in which the brain captures and processes morally salient information or initiates moral action. The question is whether there is any reason to prefer one method over the other? In this article, I argue that there is. Specifically, I argue that internal moral enhancement is likely to be preferable to external moral enhancement, when it comes to the legitimacy of political decision-making processes. In fact, I go further than this and argue that the increasingly dominant forms of external moral enhancement (algorithm-assisted enhancement) may already be posing a significant threat to political legitimacy, one that we should try to address. Consequently, research and development of internal moral enhancements should be prioritised as a political project. © 2016 Springer Science+Business Media Dordrecht