University Pierre and Marie Curie

www.upmc.fr
Paris, France

Pierre and Marie Curie University , also known as University of Paris VI , is a public research university located on the Jussieu Campus in the Latin Quarter of the 5th arrondissement of Paris, France.It was established in 1971 following the division of the University of Paris , and is a principal heir to Faculty of science of the University of Paris . The French cultural revolution of 1968, commonly known as "the French May", resulted in the division of the world's second oldest academic institution, the University of Paris, into thirteen autonomous universities.UPMC is the largest scientific and medical complex in France, active in many fields of research with scope and achievements at the highest level, as demonstrated by the many awards regularly won by UPMC researchers, and the many international partnerships it maintains across all five continents. Several university rankings have regularly put UPMC at the 1st place in France, and it has been ranked as one of the top universities in the world. The ARWU has ranked UPMC as the 1st in France, 6th in Europe and 35th in the world and also 4th in field of mathematics, 25th in field of physics, 14th in field of natural science and 32nd in field of engineering, technology and computer science.It has more than 125 laboratories, most of them in association with the Centre national de la recherche scientifique . Some of its most notable institutes and laboratories include the Institut Henri Poincaré, Institut d'Astrophysique de Paris, Laboratoire d'informatique de Paris 6 , Institut de mathématiques de Jussieu and the Laboratoire Kastler-Brossel .The University's Faculty of Medicine Pierre and Marie Curie is located in the teaching hospitals Pitié-Salpêtrière and Saint-Antoine .UPMC delivers a diploma in physics in English, since September 2013 for Université Paris-Sorbonne Abou Dhabi. Wikipedia.

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Patent
Paris Science Et Lettre Quartier Latin, French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2015-07-03

Disclosed is a functional derivative of a Photoactive Yellow Protein (PYP), or a functional fragment thereof, for fluorescently labelling particles, e.g. proteins, or surfaces, which is capable of binding reversibly a fluorogenic chromophore of formula (I), and which is capable of enhancing the brightness of the fluorogenic chromophore upon complexation thereto; and of inducing the spectral shift of the fluorogenic chromophore through the ionization of an auxochromic group thereof.


Patent
Ecole Normale Superieure de Paris, French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2016-10-26

The present invention relates to a method for the determination of a nucleic acid sequence by physical manipulation. In particular, the said method comprises the steps of denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence by applying a physical force to the said molecule; and detecting a blockage of the renaturation of the double-stranded nucleic acid molecule. More specifically, the method comprises the steps of denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence by applying a physical force to the said molecule; providing a single-stranded nucleic acid molecule; renaturing the said double stranded nucleic acid molecule in the presence of the said single-stranded nucleic acid molecule; and detecting a blockage of the renaturation of the double-stranded nucleic acid.


Patent
Ecole Normale Superieure de Paris, French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2016-10-26

The present invention relates to a method for the determination of a nucleic acid sequence by physical manipulation. The method is based on the precise determination of the localization of the replicating fork on the template by measuring the physical distance between one end of the molecule and the fork. This allows the determination of the physical location of the site where a pause or a blockage of the replication occurs, and deducing therefrom information on the sequence of the nucleic acid.


Patent
French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2016-11-03

Replication-defective lentiviral vectors are described. Using this vector, methods of directing evolution of a target polynucleotide of interest for obtaining variants of the target polynucleotide, methods to generate genetic variability by preparing a cell library, and methods to isolate and/or screen variants of a polynucleotide or variants of a protein able to impact the phenotype of a cell or to confer a desired phenotype to target cells and to identify theses polynucleotide variants or protein variants responsible for this phenotype are described.


Patent
University Pierre, Marie Curie and University of Liège | Date: 2016-11-21

A compound of formula (I-1) wherein n equals 0 or 1, Z represents O or S, R1 represents one group chosen among the group consisting of hydrogen, C1-C7 alkyl, substituted, or not, by a halogen, a hydroxyl or a OR12 group, wherein R12 is a C1-C7 alkyl, a group CH_(2)OCOR5 wherein R5 is chosen among a hydrogen atom and a C1-C7 alkyl, substituted or not by at least one halogen, a group OR13, wherein R13 is chosen among hydrogen and a C1-C7 alkyl, an amine or a CH_(2)-amine, R1 represents a group chosen among hydrogen and OR14, wherein R14 is chosen among hydrogen and a C1-C7 alkyl, and R2 is chosen among the group consisting of a C1-C7 alkyl, a C3-C6 cycloalkyl, an aryl group, and an heteroaryl group for the treatment of pathologies involving excess activity of at least one member of the kallikrein family.


Patent
Association Institute Of Myologie, French National Center for Scientific Research, French Institute of Health, Medical Research, University Pierre and Marie Curie | Date: 2015-04-14

The present invention relates to compositions and methods for treating myotonic dystrophy.


Patent
University Pierre and Marie Curie | Date: 2016-09-02

The invention relates to a peptide comprising the following amino acid sequence Thr-Phe-Leu-Lys or Thr-Phe-Leu-Lys-Cys, useful as a CCR2 non competitive antagonist peptide.


Patent
University Pierre, Marie Curie and French National Center for Scientific Research | Date: 2015-02-12

A surface coating method includes the steps of preparing a solution containing a solvent and a material or its precursor, intended to cover a surface to be coated, which is non-volatile, film-forming and soluble or can be in suspension or dispersed in a solvent; and generating an aerosol of the solution. The method further includes generating an aerosol flow from a first end of a tube towards a second end of the tube, wherein the second end pre-determined cross-section (Se) and provided with a spray nozzle having an outlet with a cross-section (S) smaller than the cross-section (Se) of the second end of the tube, such that the ratio R1=F/S is greater than 4 metres per second. The method also includes the steps of directing the outlet of the nozzle towards the surface to be coated and spraying the aerosol onto the surface to be coated.


Patent
Paris Science Et Lettres Quartier Latin, French National Center for Scientific Research, University Pierre, Marie Curie and University Paris Diderot | Date: 2016-12-16

The invention relates to an optical device for measuring the position of an object along a first axis, the object being subjected to light radiations emitted by a light source. The optical device comprises: an imaging system comprising an objective for collecting light radiations diffused by the object, the imaging system having an optical axis extending parallel to the first axis; a transmission mask having at least a first aperture and a second aperture, the first aperture and second aperture being spaced from each other along a second axis, perpendicular to the first axis, the transmission mask being arranged so as to let a first part of the radiations and a second part of the radiations which are diffused by the object pass through the first aperture and the second aperture respectively, while blocking a part of the radiations emitted by the light source which is not diffused by the object; and a detector adapted for generating an image including a first spot and a second spot representative of the first part and second part of the radiations impacting the detector plane, wherein variation of the position of the object relative to the object plane of the imaging system along the first axis causes variation of a position of the first spot and of the second spot relative to each other along the second axis.


Millecamps S.,University Pierre and Marie Curie | Julien J.-P.,Laval University
Nature Reviews Neuroscience | Year: 2013

The intracellular transport of organelles along an axon is crucial for the maintenance and function of a neuron. Anterograde axonal transport has a role in supplying proteins and lipids to the distal synapse and mitochondria for local energy requirements, whereas retrograde transport is involved in the clearance of misfolded and aggregated proteins from the axon and the intracellular transport of distal trophic signals to the soma. Axonal transport can be affected by alterations to various components of the transport machinery. Here, we review the current state of knowledge about axonal transport defects that might contribute to the pathogenesis of particular neurodegenerative diseases. © 2013 Macmillan Publishers Limited. All rights reserved.

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