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Pierre and Marie Curie University , also known as University of Paris VI , is a public research university located on the Jussieu Campus in the Latin Quarter of the 5th arrondissement of Paris, France.It was established in 1971 following the division of the University of Paris , and is a principal heir to Faculty of science of the University of Paris . The French cultural revolution of 1968, commonly known as "the French May", resulted in the division of the world's second oldest academic institution, the University of Paris, into thirteen autonomous universities.UPMC is the largest scientific and medical complex in France, active in many fields of research with scope and achievements at the highest level, as demonstrated by the many awards regularly won by UPMC researchers, and the many international partnerships it maintains across all five continents. Several university rankings have regularly put UPMC at the 1st place in France, and it has been ranked as one of the top universities in the world. The ARWU has ranked UPMC as the 1st in France, 6th in Europe and 35th in the world and also 4th in field of mathematics, 25th in field of physics, 14th in field of natural science and 32nd in field of engineering, technology and computer science.It has more than 125 laboratories, most of them in association with the Centre national de la recherche scientifique . Some of its most notable institutes and laboratories include the Institut Henri Poincaré, Institut d'Astrophysique de Paris, Laboratoire d'informatique de Paris 6 , Institut de mathématiques de Jussieu and the Laboratoire Kastler-Brossel .The University's Faculty of Medicine Pierre and Marie Curie is located in the teaching hospitals Pitié-Salpêtrière and Saint-Antoine .UPMC delivers a diploma in physics in English, since September 2013 for Université Paris-Sorbonne Abou Dhabi. Wikipedia.

Bauvois B.,University Pierre and Marie Curie
Biochimica et Biophysica Acta - Reviews on Cancer | Year: 2012

This review focuses on matrix metalloproteinases (MMPs)-2 (gelatinase A) and -9 (gelatinase B), both of which are cancer-associated, secreted, zinc-dependent endopeptidases. Gelatinases cleave many different targets (extracellular matrix, cytokines, growth factors, chemokines and cytokine/growth factor receptors) that in turn regulate key signaling pathways in cell growth, migration, invasion, inflammation and angiogenesis. Interactions with cell surface integral membrane proteins (CD44, αVβ/αβ1/αβ2 integrins and Ku protein) can occur through the gelatinases' active site or hemopexin-like C-terminal domain. This review evaluates the recent literature on the non-enzymatic, signal transduction roles of surface-bound gelatinases and their subsequent effects on cell survival, migration and angiogenesis. Gelatinases have long been drug targets. The current status of gelatinase inhibitors as anticancer agents and their failure in the clinic is discussed in light of these new data on the gelatinases' roles as cell surface transducers - data that may lead to the design and development of novel, gelatinase-targeting inhibitors. © 2011 Elsevier B.V. Source

Dujon B.,University Pierre and Marie Curie
Nature Reviews Genetics | Year: 2010

Over the past few years, genome sequences have become available from an increasing range of yeast species, which has led to notable advances in our understanding of evolutionary mechanisms in eukaryotes. Yeasts offer us a unique opportunity to examine how molecular and reproductive mechanisms combine to affect genome architectures and drive evolutionary changes over a broad range of species. This Review summarizes recent progress in understanding the molecular mechanisms-such as gene duplication, mutation and acquisition of novel genetic material-that underlie yeast evolutionary genomics. I also discuss how results from yeasts can be extended to other eukaryotes. © 2010 Macmillan Publishers Limited. All rights reserved. Source

French National Center for Scientific Research, Mohammed V University, University Pierre and Marie Curie | Date: 2014-01-22

The present invention relates to a method for determining whether a protein binds to a specific DNA sequence. This method is useful in particular for identifying modifications to the DNA sequence (e.g. methylations) via the binding of proteins that specifically recognize those modifications (e.g. antibodies), but also to identify the binding sequence on DNA of a variety of proteins.

University Pierre and Marie Curie | Date: 2014-04-25

Method for visual tracking of at least one object represented by a cluster of points with which information is associated, characterised in that it includes steps to: receive (E1) data representing a set of space-time events, determine (E2) the probability that an event in the set belongs to the cluster of points representing the at least one object, for each event in the received set, determine (E3) whether or not an event belongs to the cluster of points as a function of the determined probability for the event considered, for each event in the received set, update (E4) information associated with the cluster of points for at least one object, for each event for which it was determined in the previous step that it belongs to the cluster of points, calculate (E4, E5) the position, size and orientation of the at least one object as a function of the updated information.

Institute Curie, French National Center for Scientific Research, French Institute of Health, Medical Research, University Pierre and Marie Curie | Date: 2014-09-05

The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein:

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