Paris, France

Pierre and Marie Curie University , also known as University of Paris VI , is a public research university located on the Jussieu Campus in the Latin Quarter of the 5th arrondissement of Paris, France.It was established in 1971 following the division of the University of Paris , and is a principal heir to Faculty of science of the University of Paris . The French cultural revolution of 1968, commonly known as "the French May", resulted in the division of the world's second oldest academic institution, the University of Paris, into thirteen autonomous universities.UPMC is the largest scientific and medical complex in France, active in many fields of research with scope and achievements at the highest level, as demonstrated by the many awards regularly won by UPMC researchers, and the many international partnerships it maintains across all five continents. Several university rankings have regularly put UPMC at the 1st place in France, and it has been ranked as one of the top universities in the world. The ARWU has ranked UPMC as the 1st in France, 6th in Europe and 35th in the world and also 4th in field of mathematics, 25th in field of physics, 14th in field of natural science and 32nd in field of engineering, technology and computer science.It has more than 125 laboratories, most of them in association with the Centre national de la recherche scientifique . Some of its most notable institutes and laboratories include the Institut Henri Poincaré, Institut d'Astrophysique de Paris, Laboratoire d'informatique de Paris 6 , Institut de mathématiques de Jussieu and the Laboratoire Kastler-Brossel .The University's Faculty of Medicine Pierre and Marie Curie is located in the teaching hospitals Pitié-Salpêtrière and Saint-Antoine .UPMC delivers a diploma in physics in English, since September 2013 for Université Paris-Sorbonne Abou Dhabi. Wikipedia.

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University Pierre, Marie Curie and University of Liège | Date: 2016-11-21

A compound of formula (I-1) wherein n equals 0 or 1, Z represents O or S, R1 represents one group chosen among the group consisting of hydrogen, C1-C7 alkyl, substituted, or not, by a halogen, a hydroxyl or a OR12 group, wherein R12 is a C1-C7 alkyl, a group CH_(2)OCOR5 wherein R5 is chosen among a hydrogen atom and a C1-C7 alkyl, substituted or not by at least one halogen, a group OR13, wherein R13 is chosen among hydrogen and a C1-C7 alkyl, an amine or a CH_(2)-amine, R1 represents a group chosen among hydrogen and OR14, wherein R14 is chosen among hydrogen and a C1-C7 alkyl, and R2 is chosen among the group consisting of a C1-C7 alkyl, a C3-C6 cycloalkyl, an aryl group, and an heteroaryl group for the treatment of pathologies involving excess activity of at least one member of the kallikrein family.

University Pierre, Marie Curie and French National Center for Scientific Research | Date: 2015-02-12

A surface coating method includes the steps of preparing a solution containing a solvent and a material or its precursor, intended to cover a surface to be coated, which is non-volatile, film-forming and soluble or can be in suspension or dispersed in a solvent; and generating an aerosol of the solution. The method further includes generating an aerosol flow from a first end of a tube towards a second end of the tube, wherein the second end pre-determined cross-section (Se) and provided with a spray nozzle having an outlet with a cross-section (S) smaller than the cross-section (Se) of the second end of the tube, such that the ratio R1=F/S is greater than 4 metres per second. The method also includes the steps of directing the outlet of the nozzle towards the surface to be coated and spraying the aerosol onto the surface to be coated.

University Pierre and Marie Curie | Date: 2016-09-02

The invention relates to a peptide comprising the following amino acid sequence Thr-Phe-Leu-Lys or Thr-Phe-Leu-Lys-Cys, useful as a CCR2 non competitive antagonist peptide.

Association Institute Of Myologie, French National Center for Scientific Research, French Institute of Health, Medical Research, University Pierre and Marie Curie | Date: 2015-04-14

The present invention relates to compositions and methods for treating myotonic dystrophy.

French Atomic Energy Commission, University Pierre and Marie Curie | Date: 2015-05-20

A device for analyzing at least one oxidizable molten metal using a LIBS technique, including: a LIBS analyzer; a mechanical rotary mechanism stirring a liquid bath of the at least one oxidizable molten metal, and including a central section, to be positioned above the liquid bath of the at least one oxidizable molten metal, including an internal cavity forming an analysis chamber, the central section including a first end connected to the LIBS analyzer, and a plurality of mechanical stirring paddles to be partially submerged in the liquid bath of the at least one oxidizable molten metal and that are connected to a second end of the central section opposite the first end of the central section, the LIBS analyzer configured to allow the surface of the at least one oxidizable molten metal located in the portion plumb with the internal cavity of the central portion to be analyzed.

Ecole Normale Superieure de Paris, French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2016-10-26

The present invention relates to a method for the determination of a nucleic acid sequence by physical manipulation. The method is based on the precise determination of the localization of the replicating fork on the template by measuring the physical distance between one end of the molecule and the fork. This allows the determination of the physical location of the site where a pause or a blockage of the replication occurs, and deducing therefrom information on the sequence of the nucleic acid.

French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2016-11-03

Replication-defective lentiviral vectors are described. Using this vector, methods of directing evolution of a target polynucleotide of interest for obtaining variants of the target polynucleotide, methods to generate genetic variability by preparing a cell library, and methods to isolate and/or screen variants of a polynucleotide or variants of a protein able to impact the phenotype of a cell or to confer a desired phenotype to target cells and to identify theses polynucleotide variants or protein variants responsible for this phenotype are described.

Ecole Normale Superieure de Paris, French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2016-10-26

The present invention relates to a method for the determination of a nucleic acid sequence by physical manipulation. In particular, the said method comprises the steps of denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence by applying a physical force to the said molecule; and detecting a blockage of the renaturation of the double-stranded nucleic acid molecule. More specifically, the method comprises the steps of denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence by applying a physical force to the said molecule; providing a single-stranded nucleic acid molecule; renaturing the said double stranded nucleic acid molecule in the presence of the said single-stranded nucleic acid molecule; and detecting a blockage of the renaturation of the double-stranded nucleic acid.

French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2015-04-24

Asynchronous information is provided by a sensor having a matrix of pixels disposed opposite the scene. The asynchronous information includes, for each pixel of the matrix, successive events originating from this pixel, that may depend on variations of light in the scene. A model representing the tracked shape of an object is updated after detecting events attributed to this object in the asynchronous information. Following detection, the updating of the model includes an association of a point of the model with the event detected by minimizing a criterion of distance with respect to the pixel of the matrix from which the detected event originates. The updated model is then determined as a function of the pixel of the matrix from which the detected event originates and attributed to the object and of the associated point in the model, independently of the associations performed before the detection of this event.

Loeuille N.,University Pierre and Marie Curie | Loeuille N.,French National Institute for Agricultural Research
Ecology Letters | Year: 2010

In randomly assembled communities, diversity is known to have a destabilizing effect. Evolution may affect this result, but our theoretical knowledge of its role is mostly limited to models of small food webs. In the present article, I introduce evolution in a two-species Lotka-Volterra model in which I vary the interaction type and the cost constraining evolution. Regardless of the cost type, evolution tends to stabilize the dynamics more often in trophic interactions than for mutualism or competition. I then use simulations to study the effect of evolution in larger communities that contain all interaction types. Results suggest that evolution usually stabilizes the dynamics. This stabilizing effect is stronger when evolution affects trophic interactions, but happens for all interaction types. Stabilization decreases with diversity and evolution becomes destabilizing in very diverse communities. This suggests that evolution may not counteract the destabilizing effect of diversity observed in random communities. © 2010 Blackwell Publishing Ltd/CNRS.

Taddei A.,University Pierre and Marie Curie | Gasser S.M.,Friedrich Miescher Institute for Biomedical Research
Genetics | Year: 2012

Budding yeast, like other eukaryotes, carries its genetic information on chromosomes that are sequestered from other cellular constituents by a double membrane, which forms the nucleus. An elaborate molecular machinery forms large pores that span the double membrane and regulate the traffic of macromolecules into and out of the nucleus. In multicellular eukaryotes, an intermediate filament meshwork formed of lamin proteins bridges from pore to pore and helps the nucleus reform after mitosis. Yeast, however, lacks lamins, and the nuclear envelope is not disrupted during yeast mitosis. The mitotic spindle nucleates from the nucleoplasmic face of the spindle pole body, which is embedded in the nuclear envelope. Surprisingly, the kinetochores remain attached to short microtubules throughout interphase, influencing the position of centromeres in the interphase nucleus, and telomeres are found clustered in foci at the nuclear periphery. In addition to this chromosomal organization, the yeast nucleus is functionally compartmentalized to allow efficient gene expression, repression, RNA processing, genomic replication, and repair. The formation of functional subcompartments is achieved in the nucleus without intranuclear membranes and depends instead on sequence elements, protein-protein interactions, specific anchorage sites at the nuclear envelope or at pores, and long-range contacts between specific chromosomal loci, such as telomeres. Here we review the spatial organization of the budding yeast nucleus, the proteins involved in forming nuclear subcompartments, and evidence suggesting that the spatial organization of the nucleus is important for nuclear function. © 2012 by the Genetics Society of America.

Billard C.,University Pierre and Marie Curie
Leukemia | Year: 2012

Impaired programmed cell death is an important factor in the pathogenesis of chronic lymphocytic leukemia (CLL) and in the development of resistance to chemoimmunotherapy. Hence, the reactivation of apoptotic processes is likely to be a pertinent strategy for circumventing this resistance. Proteins from the Bcl-2 family are critical elements in defective apoptosis. Some compounds induce the apoptosis of CLL cells ex vivo by downregulation of prosurvival members of this family (for example, Bcl-2 and Mcl-1), whereas others act by upregulation of proapoptotic Bcl-2 homology (BH) 3-only members (for example, Noxa and Bim). The concept of BH3 mimetics was prompted by the fact that BH3-only proteins are specific antagonistic ligands of prosurvival Bcl-2 family members. This led to the design of small molecules capable of inhibiting the activity of prosurvival Bcl-2 proteins and inducing apoptosis in leukemia cells in vitro and antileukemic effects in animal models. Several putative or actual BH3 mimetics are currently being trialed in the clinic. Two novel BH3 mimetics that can specifically bind to and antagonize Mcl-1 (a crucial antiapoptotic factor in CLL) have recently been discovered. The evaluation of this type of compounds clinical impact in CLL can now be considered. © 2012 Macmillan Publishers Limited All rights reserved.

Pitaval A.,Institute Of Recherche En Science Et Technologies Pour Le Vivant | Tseng Q.,French National Institute for Agricultural Research | Bornens M.,University Pierre and Marie Curie | Thery M.,French National Institute for Agricultural Research
Journal of Cell Biology | Year: 2010

In most lineages, cell cycle exit is correlated with the growth of a primary cilium. We analyzed cell cycle exit and ciliogenesis in human retinal cells and found that, contrary to the classical view, not all cells exiting the cell division cycle generate a primary cilium. Using adhesive micropatterns to control individual cell spreading, we demonstrate that cell spatial confinement is a major regulator of ciliogenesis. When spatially confined, cells assemble a contractile actin network along their ventral surface and a protrusive network along their dorsal surface. The nucleus-centrosome axis in confined cells is oriented toward the dorsal surface where the primary cilium is formed. In contrast, highly spread cells assemble mostly contractile actin bundles. The nucleus-centrosome axis of spread cells is oriented toward the ventral surface, where contractility prevented primary cilium growth. These results indicate that cell geometrical confinement affects cell polarity via the modulation of actin network architecture and thereby regulates basal body positioning and primary cilium growth. © 2010 Pitaval et al.

Marchetti M.C.,Syracuse Biomaterials Institute | Joanny J.F.,University Pierre and Marie Curie | Ramaswamy S.,Indian Institute of Science | Liverpool T.B.,University of Bristol | And 5 more authors.
Reviews of Modern Physics | Year: 2013

This review summarizes theoretical progress in the field of active matter, placing it in the context of recent experiments. This approach offers a unified framework for the mechanical and statistical properties of living matter: biofilaments and molecular motors in vitro or in vivo, collections of motile microorganisms, animal flocks, and chemical or mechanical imitations. A major goal of this review is to integrate several approaches proposed in the literature, from semimicroscopic to phenomenological. In particular, first considered are "dry" systems, defined as those where momentum is not conserved due to friction with a substrate or an embedding porous medium. The differences and similarities between two types of orientationally ordered states, the nematic and the polar, are clarified. Next, the active hydrodynamics of suspensions or "wet" systems is discussed and the relation with and difference from the dry case, as well as various large-scale instabilities of these nonequilibrium states of matter, are highlighted. Further highlighted are various large-scale instabilities of these nonequilibrium states of matter. Various semimicroscopic derivations of the continuum theory are discussed and connected, highlighting the unifying and generic nature of the continuum model. Throughout the review, the experimental relevance of these theories for describing bacterial swarms and suspensions, the cytoskeleton of living cells, and vibrated granular material is discussed. Promising extensions toward greater realism in specific contexts from cell biology to animal behavior are suggested, and remarks are given on some exotic active-matter analogs. Last, the outlook for a quantitative understanding of active matter, through the interplay of detailed theory with controlled experiments on simplified systems, with living or artificial constituents, is summarized. © 2013 American Physical Society.

Sinclair J.C.,Laboratory of Molecular Biophysics | Davies K.M.,Laboratory of Molecular Biophysics | Venien-Bryan C.,Laboratory of Molecular Biophysics | Venien-Bryan C.,University Pierre and Marie Curie | Noble M.E.M.,Laboratory of Molecular Biophysics
Nature Nanotechnology | Year: 2011

The self-assembly of supramolecular structures that are ordered on the nanometre scale is a key objective in nanotechnology. DNA 1-4 and peptide 5-7 nanotechnologies have produced various two- and three-dimensional structures, but protein molecules have been underexploited in this area of research. Here we show that the genetic fusion of subunits from protein assemblies that have matching rotational symmetry generates species that can self-assemble into well-ordered, pre-determined one- and two-dimensional arrays that are stabilized by extensive intermolecular interactions. This new class of supramolecular structure provides a way to manufacture biomaterials with diverse structural and functional properties. © 2011 Macmillan Publishers Limited. All rights reserved.

Komajda M.,University Pierre and Marie Curie | Lam C.S.P.,National University of Singapore
European Heart Journal | Year: 2014

Heart failure with preserved ejection fraction (HFpEF) is now recognized as a major and growing public health problem worldwide. Yet significant uncertainties still surround its pathophysiology and treatment, leaving clinicians in a dilemma regarding its optimal management. Whether HFpEF and heart failure with reduced ejection fraction (HFrEF) are two distinct entities or two ends of a common spectrum remains a matter of debate. In particular, the lack of benefit observed with renin-angiotensin system blockers has raised questions regarding our understanding of the pathophysiology of HFpEF. New paradigms including a prominent role of co-morbidities, inflammation, endothelial dysfunction, and pro-hypertrophic signalling pathways have been proposed. Recent proof-of-concept trials using a phosphodiesterase inhibitor, a mineralocorticoid receptor antagonist, an angiotensin receptor/neprilysin inhibitor, a soluble guanylate cyclase stimulator, or a sino atria, if current blocker provide important insight for the development of novel therapeutic strategies in HFpEF. © 2014 The Author.

Sterdyniak A.,University of Innsbruck | Cooper N.R.,Tcm Group | Regnault N.,Princeton University | Regnault N.,University Pierre and Marie Curie
Physical Review Letters | Year: 2015

In two dimensions strongly interacting bosons in a magnetic field can realize a bosonic integer quantum Hall state, the simplest two-dimensional example of a symmetry-protected topological phase. We propose a realistic implementation of this phase using an optical flux lattice. Through exact diagonalization calculations, we show that the system exhibits a clear bulk gap and the topological signature of the bosonic integer quantum Hall state. In particular, the calculation of the many-body Chern number leads to a quantized Hall conductance in agreement with the analytical predictions. We also study the stability of the phase with respect to some of the experimentally relevant parameters. © 2015 American Physical Society. © 2015 American Physical Society.

Kuttippurath J.,University Pierre and Marie Curie | Nikulin G.,Swedish Meteorological and Hydrological Institute
Atmospheric Chemistry and Physics | Year: 2012

We present an analysis of the major sudden stratospheric warmings (SSWs) in the Arctic winters 2003/04-2009/10. There were 6 major SSWs (major warmings [MWs]) in 6 out of the 7 winters, in which the MWs of 2003/04, 2005/06, and 2008/09 were in January and those of 2006/07, 2007/08, and 2009/10 were in February. Although the winter 2009/10 was relatively cold from mid-December to mid-January, strong wave 1 activity led to a MW in early February, for which the largest momentum flux among the winters was estimated at 60° N/10 hPa, about 450 m 2 s -2. The strongest MW, however, was observed in 2008/09 and the weakest in 2006/07. The MW in 2008/09 was triggered by intense wave 2 activity and was a vortex split event. In contrast, strong wave 1 activity led to the MWs of other winters and were vortex displacement events. Large amounts of Eliassen-Palm (EP) and wave 1/2 EP fluxes (about 2-4 ×10 5 kg s -2) are estimated shortly before the MWs at 100 hPa averaged over 45-75° N in all winters, suggesting profound tropospheric forcing for the MWs. We observe an increase in the occurrence of MWs (∼1.1 MWs/winter) in recent years (1998/99-2009/10), as there were 13 MWs in the 12 Arctic winters, although the long-term average (1957/58-2009/10) of the frequency stays around its historical value (∼0.7 MWs/winter), consistent with the findings of previous studies. An analysis of the chemical ozone loss in the past 17 Arctic winters (1993/94-2009/10) suggests that the loss is inversely proportional to the intensity and timing of MWs in each winter, where early (December-January) MWs lead to minimal ozone loss. Therefore, this high frequency of MWs in recent Arctic winters has significant implications for stratospheric ozone trends in the northern hemisphere. © 2012 Author(s).

Poupon R.,University Pierre and Marie Curie | Poupon R.,French Institute of Health and Medical Research
Journal of Hepatology | Year: 2010

Primary biliary cirrhosis (PBC) is a chronic inflammatory autoimmune disease that mainly targets the cholangiocytes of the interlobular bile ducts in the liver. The condition primarily affects middle-aged women. Without treatment, PBC generally progresses to cirrhosis and eventually liver failure over a period of 10-20 years. PBC is a rare disease with prevalence of less than 1/2000. PBC is thought to result from a combination of multiple genetic factors and superimposed environmental triggers. The contribution of the genetic predisposition is evidenced by the familial clustering. Several risk factors, including exposure to infectious agents and chemical xenobiotics, have been suggested. Ursodeoxycholic acid (UDCA) is currently the only FDA-approved medical treatment for PBC. When administered at doses of 13-15 mg/kg/day, a majority of patients with PBC have a normal life expectancy without additional therapeutic measures. One out of three patients does not adequately respond to UDCA therapy and may need additional medical therapy and/or liver transplantation. This review summarises current knowledge on the epidemiology, ethiopathogenesis, clinical, and therapeutic aspects of PBC. © 2010 European Association for the Study of the Liver.

Plehn T.,University of Heidelberg | Salam G.P.,University Pierre and Marie Curie | Spannowsky M.,Karlsruhe Institute of Technology | Spannowsky M.,University of Oregon
Physical Review Letters | Year: 2010

At the LHC associated top quark and Higgs boson production with a Higgs boson decay to bottom quarks has long been a heavily disputed search channel. Recently, it has been found not to be viable. We show how it can be observed by tagging massive Higgs bosons and top jets. For this purpose we construct boosted top and Higgs taggers for standard-model processes in a complex QCD environment. © 2010 The American Physical Society.

Aron-Wisnewsky J.,University Pierre and Marie Curie | Dore J.,French National Institute for Agricultural Research | Clement K.,University Pierre and Marie Curie
Nature Reviews Gastroenterology and Hepatology | Year: 2012

The gut microbiota is recognized to have an important role in energy storage and the subsequent development of obesity. To date, bariatric surgery (indicated for severe obesity) represents the only treatment that enables substantial and sustained weight loss. Bariatric surgery is also a good model to study not only the pathophysiology of obesity and its related diseases but also the mechanisms involved in their improvement after weight reduction. Scarce data from humans and animal models have demonstrated that gut microbiota composition is modified after Roux-en-Y gastric bypass (RYGB), suggesting that weight reduction could affect gut microbiota composition. However, weight loss might not be the only factor responsible for those modifications. Indeed, bariatric surgery not only improves hormonal and inflammatory status, but also induces numerous changes in the digestive tract that might account for the observed modifications of microbiota ecology. In future bariatric surgery studies in humans or mice, these major surgery-induced modifications will need to be taken into account when analyzing the link between gut microbiota composition, obesity, its complications and their improvement after bariatric surgery. This Review outlines the potential mechanisms by which the major changes in the digestive tract after bariatric surgery can affect the gut microbiota. © 2012 Macmillan Publishers Limited. All rights reserved.

Bolopion A.,FEMTO ST Institute | Regnier S.,University Pierre and Marie Curie
IEEE Transactions on Automation Science and Engineering | Year: 2013

This paper presents a review of the major haptic feedback teleoperation systems for micromanipulation. During the last decade, the handling of micrometer-sized objects has become a critical issue. Fields of application from material science to electronics demonstrate an urgent need for intuitive and flexible manipulation systems able to deal with small-scale industrial projects and assembly tasks. Two main approaches have been considered: fully automated tasks and manual operation. The first one require fully pre determined tasks, while the later necessitates highly trained operators. To overcome these issues the use of haptic feedback teleoperation where the user manipulates the tool through a joystick whilst feeling a force feedback, appears to be a promising solution as it allows high intuitiveness and flexibility. Major advances have been achieved during this last decade, starting with systems that enable the operator to feel the substrate topology, to the current state-of-the-art where 3D haptic feedback is provided to aid manipulation tasks. This paper details the major achievements and the solutions that have been developed to propose 3D haptic feedback for tools that often lack 3D force measurements. The use of virtual reality to enhance the immersion is also addressed. The strategies developed provide haptic feedback teleoperation systems with a high degree of assistance and for a wide range of micromanipulation tools. Based on this expertise on haptic for micromanipulation and virtual reality assistance it is now possible to propose microassembly systems for objects as small as 1 to 10 micrometers. This is a mature field and will benefit small-scale industrial projects where precision and flexibility in microassembly are required. © 2013 IEEE.

Georges A.,Ecole Polytechnique - Palaiseau | Georges A.,Collège de France | Georges A.,University of Geneva | De Medici L.,University Paris - Sud | And 4 more authors.
Annual Review of Condensed Matter Physics | Year: 2013

Strong electronic correlations are often associated with the proximity of a Mott-insulating state. In recent years however, it has become increasingly clear that the Hund's rule coupling (intra-atomic exchange) is responsible for strong correlations in multiorbital metallic materials that are not close to a Mott insulator. Hund's coupling has two effects: It influences the energetics of the Mott gap and strongly suppresses the coherence scale for the formation of a Fermi liquid. A global picture has emerged recently, which emphasizes the importance of the average occupancy of the shell as a control parameter. The most dramatic effects occur away from half-filling or single occupancy. We review the theoretical understanding and physical properties of these Hund's metals, together with the relevance of this concept to transition-metal oxides (TMOs) of the 3d, and especially 4d, series (such as ruthenates), as well as to the iron-based superconductors (iron pnictides and chalcogenides). © 2013 by Annual Reviews. All rights reserved.

Rodriguez R.,CNRS Natural Product Chemistry Institute | Rodriguez R.,University Pierre and Marie Curie | Miller K.M.,University of Texas at Austin
Nature Reviews Genetics | Year: 2014

Small molecules-including various approved and novel cancer therapeutics-can operate at the genomic level by targeting the DNA and protein components of chromatin. Emerging evidence suggests that functional interactions between small molecules and the genome are non-stochastic and are influenced by a dynamic interplay between DNA sequences and chromatin states. The establishment of genome-wide maps of small-molecule targets using unbiased methodologies can help to characterize and exploit drug responses. In this Review, we discuss how high-throughput sequencing strategies, such as ChIP-seq (chromatin immunoprecipitation followed by sequencing) and Chem-seq (chemical affinity capture and massively parallel DNA sequencing), are enabling the comprehensive identification of small-molecule target sites throughout the genome, thereby providing insights into unanticipated drug effects.

Leroy B.,University Pierre and Marie Curie | Soussi T.,University Pierre and Marie Curie
Human Mutation | Year: 2014

More than 50% of human tumors carry TP53 gene mutations and in consequence more than 45,000 somatic and germline mutations have been gathered in the UMD TP53 database ( Analyses of these mutations have been invaluable for bettering our knowledge on the structure-function relationships within the TP53 protein and the high degree of heterogeneity of the various TP53 mutants in human cancer. In this review, we discuss how with the release of the sequences of thousands of tumor genomes issued from high-throughput sequencing, the description of novel TP53 mutants is now reaching a plateau indicating that we are close to the full set of mutants that target the elusive tumor-suppressive activity of this protein. We performed an extensive and thorough analysis of the TP53 mutation database, focusing particularly on specific sets of mutations that were overlooked in the past because of their low frequencies, for example, synonymous mutations, splice mutations, or mutations-targeting residues subject to posttranslational modifications. We also discuss the evolution of the statistical methods used to differentiate TP53 passenger mutations and artifactual data from true mutations, a process vital to the release of an accurate TP53 mutation database that will in turn be an invaluable tool for both clinicians and researchers. © 2014 WIley Periodicals, Inc.

University Pierre, Marie Curie, Endocontrol, Mauna Kea Technologies and French National Center for Scientific Research | Date: 2012-06-25

The invention relates to an endoscopic instrument (1) having an elongate body with a distal end (4) designed to be introduced into the body of the patient so as to come into proximity with an internal organ, the distal end carrying a tool (7) for intervention on the internal organ. The endoscopic instrument has a fool (10) rigidly connected to the distal end and designed to bear on the internal organ, and also controllable means (13) for conferring movements on the tool, at least in directions transverse to a longitudinal axis (X) of the distal end of the endoscopic instrument, when the foot is bearing against the internal organ.

Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: ICT-2013.9.9 | Award Amount: 74.61M | Year: 2013

This Flagship aims to take graphene and related layered materials from a state of raw potential to a point where they can revolutionize multiple industries from flexible, wearable and transparent electronics, to new energy applications and novel functional composites.\nOur main scientific and technological objectives in the different tiers of the value chain are to develop material technologies for ICT and beyond, identify new device concepts enabled by graphene and other layered materials, and integrate them to systems that provide new functionalities and open new application areas.\nThese objectives are supported by operative targets to bring together a large core consortium of European academic and industrial partners and to create a highly effective technology transfer highway, allowing industry to rapidly absorb and exploit new discoveries.\nThe Flagship will be aligned with European and national priorities to guarantee its successful long term operation and maximal impact on the national industrial and research communities.\nTogether, the scientific and technological objectives and operative targets will allow us to reach our societal goals: the Flagship will contribute to sustainable development by introducing new energy efficient and environmentally friendly products based on carbon and other abundant, safe and recyclable natural resources, and boost economic growth in Europe by creating new jobs and investment opportunities.

Agency: Cordis | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CSA) under the 7th framework program (2013-2016), while this and the following parts are implemented as Core Projects under the Horizon 2020 framework. The mission of the Graphene Flagship is to take graphene and related layered materials from a state of raw potential to a point where they can revolutionise multiple industries. This will bring a new dimension to future technology a faster, thinner, stronger, flexible, and broadband revolution. Our program will put Europe firmly at the heart of the process, with a manifold return on the EU investment, both in terms of technological innovation and economic growth. To realise this vision, we have brought together a larger European consortium with about 150 partners in 23 countries. The partners represent academia, research institutes and industries, which work closely together in 15 technical work packages and five supporting work packages covering the entire value chain from materials to components and systems. As time progresses, the centre of gravity of the Flagship moves towards applications, which is reflected in the increasing importance of the higher - system - levels of the value chain. In this first core project the main focus is on components and initial system level tasks. The first core project is divided into 4 divisions, which in turn comprise 3 to 5 work packages on related topics. A fifth, external division acts as a link to the parts of the Flagship that are funded by the member states and associated countries, or by other funding sources. This creates a collaborative framework for the entire Flagship.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: Ocean.2010-1 | Award Amount: 14.85M | Year: 2011

The Arctic is engaged in a deep climatic evolution. This evolution is quite predictable at short (year) and longer scales (several decades), but it is the decadal intermediate scale that is the most difficult to predict. This is because the natural variability of the system is large and dominant at this scale, and the system is highly non linear due to positive and negative feedback between sea ice, the ocean and atmosphere. Already today, due to the increase of the GHG concentration in the atmosphere and the amplification of global warming in the Arctic, the impacts of climate change in the region are apparent, e.g. in the reduction in sea ice, in changes in weather patterns and cyclones or in the melting of glaciers and permafrost. It is therefore not surprising that models clearly predict that Artic sea ice will disappear in summer within 20 or 30 years, yielding new opportunities and risks for human activities in the Arctic. This climatic evolution is going to have strong impacts on both marine ecosystems and human activities in the Arctic. This in turn has large socio-economic implications for Europe. ACCESS will evaluate climatic impacts in the Arctic on marine transportation (including tourism), fisheries, marine mammals and the extraction of hydrocarbons for the next 20 years; with particular attention to environmental sensitivities and sustainability. These meso-economic issues will be extended to the macro-economic scale in order to highlight trans-sectoral implications and provide an integrated assessment of the socio-economic impact of climate change. An important aspect of ACCESS, given the geostrategic implication of Arctic state changes, will be the consideration of Arctic governance issues, including the framework UNCLOS (United Nations Convention for the Law of the Sea). ACCESS dedicates a full work package to integrate Arctic climate changes, socioeconomic impacts and Arctic governance issues.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.8.0 | Award Amount: 3.33M | Year: 2010

The central aim of iSense is to deliver breakthrough enabling technologies and knowledge to push long-anticipated sensor and quantum ICT applications using cold atoms to a broadly accessible and commercially exploitable level.\n\nTo achieve this goal, iSense is structured in two highly interlinked and temporally overlapping phases: In the phase 1 iSense will create a science and technology platform introducing novel integrated optics concepts for cold atom production and interrogation. Phase 2 will pursue the establishment of commercial cold atom devices for a wide variety of integrated quantum sensors as well as in information and communication technologies (ICT). Starting with the realization of an integrated high-precision gravity sensor and strong technology dissemination activities this phase will lay the foundations for applications-specific broadening and wide use of the technol-ogy platform beyond the extension of this project.\n\nThe long term vision is a modular, scalable and portable quantum technology family based on cold atoms, adaptable to a wide variety of applications in diverse working envi-ronments. Potential applications include fundamental physics tests, quantum ICT devices, satel-lite geodesy, oil / mineral prospecting and communication network timing.

Agency: Cordis | Branch: FP7 | Program: NOE | Phase: ICT-2007.1.1 | Award Amount: 9.17M | Year: 2008

NEWCOM\\ is the acronym of a proposed Network of Excellence in Wireless COMmunications, submitted to Call 1 of the VII Framework Programme under the Objective ICT-2007.1.1: The Network of the Future, mainly in its target direction Ubiquitous network infrastructure and architectures. The current proposal draws inspiration, shape/form, and substantive direction from its successful predecessor, the NoE NEWCOM, which was approved and funded by the EC for 36 months starting March 1st, 2004 and ending February 28, 2007. At the same time, NEWCOM\\ aspires to inject new vision, expanded roles, ever-higher degrees of research integration, and a definitive roadmap to financial security for the long-term life of this undertaking in the European research and higher-learning space. The core concept of NEWCOM\\ is that of an NoE of medium size, greatly reduced from the initial NEWCOM Consortium, formed by keeping the most committed and performing partners, exploiting the successful integration tools that NEWCOM designed and activated, and which is created for the purpose of scientifically addressing medium/long term, complex, interdisciplinary, fundamental research problems in the field of wireless networks, focused towards identifying, posing in the right modelling perspective, and at least partially characterizing the information-communication theoretical limits. Its main objectives are: Identify a selective set of scenarios, Define suitable performance measures that take into account the wireless channel nature, Perform a detailed analysis of the main theoretical results available, Evaluate information-theoretical bounds on the achievable performance, Design and analyze transmitting/receiving algorithms and protocols in order to approach those limits, Analyze implementation aspects of the above algorithms in flexible, energy-aware user terminals, Output the major findings into an integrated simulation library, Enhance the already good cooperation level among research

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: ENV.2007. | Award Amount: 4.07M | Year: 2008

ACOBAR will develop an observing system for the interior of the Arctic Ocean based on underwater acoustic methods including tomography, data transmission and communication to/from underwater platforms, and navigation of gliders. ACOBAR offers complementary methods to the ARGO system, which has limited capability in ice-covered seas. Data collection and transmission from the water column, the seafloor and the subseafloor will be possible in ice-covered seas based on research conducted in ACOBAR. The research will contribute to filling gaps in the global ocean observing system and thereby support the development of GEOSS. ACOBAR will implement field experiments with acoustic sources and receivers as well as gliders in the Fram Strait. Acoustic travel time data will be used to obtain integrated 3-D fields of temperature, transports and heat fluxes. Long-range acoustic navigation commands will be tested to operate gliders. Data transmission from fixed moorings via acoustic modems to the surface for downloading from ships or for satellite transmission will be implemented. The existing array of acoustic sources from ice-tethered platforms in the Arctic Ocean will be tested for tomographic measurements of water mass properties. Data from tomography arrays and other underwater platforms will be disseminated to users with near real-time capability, including assimilation in ocean models. ACOBAR will extend and improve methods for underwater data collection that was first tested in DAMOCLES IP. The acoustic technologies in ACOBAR aim to be used for transmission of multidisciplinary data from underwater observatories developed in ESONET NoE. Transfer of technology and know-how from USA to Europe and between industry and research institutes will take place, with exchange of scientists, workshops and meetings between scientists, engineers and students. The consortium consists of 9 partners, of which three are SMEs and six are research and educational institutions.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2007.8.0 | Award Amount: 1.83M | Year: 2008

NIW will investigate possibilities for the integrated and interchangeable use of the haptic and auditory modality in floor interfaces, and for the synergy of perception and action in capturing and guiding human walking. Its objective is to provide closed-loop interaction paradigms, negotiated with users and validated through experiments, enabling the transfer of skills that have been previously learned in everyday tasks associated to walking, and where multi-sensory feedback and sensory substitution can be exploited to create unitary multimodal percepts. NIW will expose walkers to virtual scenes presenting grounds of different natures, populated with natural obstacles and human artefacts, in which to situate the sensing and display of haptic and acoustic information for interactive simulation, and where vision will play an integrative role. Experiments will measure the ecological validity of such scenarios, investigating also on the cognitive aspects of the underlying perceptual processes. Floor based interfaces will be designed and prototyped by making use of existing haptic and acoustic sensing and actuation devices, comprising interactive floor tiles and soles, with special attention to simplicity of technology. Its applicability to navigation aids such as land-marking, guidance to locations of interest, signalling, warning about obstacles and restricted areas, will be assessed. NIW will nurture floor and shoe designs which may impact the way we get information from the environment. FET-Open will further benefit from the discovery of cross-modal psychophysical phenomena, the design of ecologically valid walking interaction paradigms, the modelling of motion analysis and multimodal display synthesis algorithms, the study of non visual floor-based navigation aids, and the development of guidelines for the use of existing sensing and actuation technologies to create virtual walking interaction scenarios.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: ENV.2010.2.2.1-1 | Award Amount: 9.65M | Year: 2010

EURO-BASIN is designed to advance our understanding on the variability, potential impacts, and feedbacks of global change and anthropogenic forcing on the structure, function and dynamics of the North Atlantic and associated shelf sea ecosystems as well as the key species influencing carbon sequestering and ecosystem functioning. The ultimate goal of the program is to further our capacity to manage these systems in a sustainable manner following the ecosystem approach. Given the scope and the international significance, EURO-BASIN is part of a multidisciplinary international effort linked with similar activities in the US and Canada. EURO-BASIN focuses on a number of key groups characterizing food web types, e.g. diatoms versus microbial loop players; key species copepods of the genus Calanus; pelagic fish, herring (Clupea harengus), mackerel (Scomber scombrus), blue whiting (Micromesistius poutassou) which represent some of the largest fish stocks on the planet; piscivorous pelagic bluefin tuna (Thunnus thynnus) and albacore (Thunnus alalunga) all of which serve to structure the ecosystem and thereby influence the flux of carbon from the euphotic zone via the biological carbon pump. In order to establish relationships between these key players, the project identifies and accesses relevant international databases and develops methods to integrate long term observations. These data will be used to perform retrospective analyses on ecosystem and key species/group dynamics, which are augmented by new data from laboratory experiments, mesocosm studies and field programs. These activities serve to advance modelling and predictive capacities based on an ensemble approach where modelling approaches such as size spectrum; mass balance; coupled NPZD; fisheries; and end to end models and as well as ecosystem indicators are combined to develop understanding of the past, present and future dynamics of North Atlantic and shelf sea ecosystems and their living marine resources.

Agency: Cordis | Branch: FP7 | Program: CP-CSA | Phase: SPA.2011.1.5-02 | Award Amount: 27.65M | Year: 2011

MACC II (Monitoring Atmospheric Composition and Climate Interim Implementation) is designed to meet the requirements that have been expressed for prototype operational GMES services for the atmospheric domain. From late-2011 MACC II will continue the operation and development of the GMES service lines established by the MACC project and prepare for its transition in 2014 to become the atmospheric monitoring component of GMES Operations. MACC II will prepare for full operations in terms of continuity, sustainability and availability. It will maintain and further develop the efficiency and resilience of its end-to-end processing system, and will refine the quality of the products of the system. It will adapt the system to make use of observations from new satellites, in particular the first of the atmospheric Sentinels, and will interface with FP7 RTD projects that contribute towards long-term service improvement. MACC II will ensure that its service lines best meet both the requirements of downstream-service providers and end users, and the requirements of the global scientific user community. The service lines will cover air quality, climate forcing, stratospheric ozone and solar radiation. MACC II will deliver products and information that support the establishment and implementation of European policy and wider international programmes. It will acquire and assimilate observational data to provide sustained real-time and retrospective global monitoring of greenhouse gases, aerosols and reactive gases such as tropospheric ozone and nitrogen dioxide. It will provide daily global forecasts of atmospheric composition, detailed air-quality forecasts and assessments for Europe, and key information on long range transport of atmospheric pollutants. It will provide comprehensive web-based graphical products and gridded data. Feedback will be given to space agencies and providers of in situ data on the quality of their data and future observational requirements.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2013.6.2-8 | Award Amount: 12.42M | Year: 2013

The MIDAS project addresses fundamental environmental issues relating to the exploitation of deep-sea mineral and energy resources; specifically polymetallic sulphides, manganese nodules, cobalt-rich ferromanganese crusts, methane hydrates and the potential mining of rare earth elements. These new industries will have significant impacts on deep-sea ecosystems, in some cases extending over hundreds of thousands of square kilometres. Scientific knowledge is needed urgently to develop guidelines for industry ensuring wealth creation and Best Environmental Practice. MIDAS will assess the nature and scales of the potential impacts including 1) physical destruction of the seabed by mining, the creation of mine tailings and the potential for catastrophic slope failures from methane hydrate exploitation, 2) the potential effects of particle-laden plumes in the water column, and 3) the possible toxic chemicals that might be released by the mining process. Knowledge of the impacts will be used to address the key biological unknowns, such as connectivity between populations, impacts of the loss of biological diversity on ecosystem functioning, and how quickly the ecosystems will recover. The information derived will be used to guide recommendations for best practice, iterating with MIDAS industry partners and the wider stakeholder community to ensure that solutions are practical and cost-effective. We will engage with European and international regulatory organisations to take these recommendations forward into legislation in a timely fashion. A major element of MIDAS will be to develop methods and technologies for 1) preparing baseline assessments of biodiversity, and 2) monitoring activities remotely in the deep sea during and after exploitation (including ecosystem recovery). The MIDAS partnership represents a unique combination of scientists, industry, social scientists, legal experts, NGOs and SMEs.

Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 4.06M | Year: 2013

It is estimated that touch screen module revenues will reach $23.9 billion by 2017. These user interfaces have become one of the most common input devices for digital media, e.g. in mobile phones and computers. Current devices incorporate relatively primitive vibrotactile haptic-feedback. The aim of PROTOTOUCH is to develop tactile displays with high fidelity haptic recognition, so that buttons would press and release like those on a real keyboard, for example, which would considerably enhance the user performance, ease of use and user experience of touch screens. Compared to visual and audio rendering, this is an immense technological challenge, particularly given the practical constraints such as cost, power and size etc. PROTOTOUCH will train 11 Early Stage Researchers (ESRs) and 4 Experienced Researchers (ERs) as a new cohort of researchers that will adopt a radically new approach to overcome the immense development challenges in the design of next generation TDs. The focus of the training will be on (a) the exploitation of the biological processes that evoke the sense of touch, (b) the application of advanced numerical techniques, such as multiscale multiphysics virtual prototyping and information processing, and (c) the translation of innovative technology into commercially viable mass-market and niche products. The ITN will involve a study of the mechanical interactions between a finger pad and a tactile display, the peripheral and central neural response that is evoked and the tactile perception of the subject. The neuromechanical interactions will form the basis of virtual prototyping. The human and virtual data will be analysed using advanced information techniques to delineate the factors that govern the performance of the displays and thus guide the design and optimisation of virtual prototypes prior to fabrication and testing.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SPA.2011.1.5-03 | Award Amount: 3.36M | Year: 2011

The first level of GMES applications in the marine area is mostly represented by the upstream services of the MCS (e.g. MyOcean). Unfortunately, the current MyOcean offering of products and services for biogeochemistry has limitations that prevent a full uptake by the potential users. The present project proposes to address these issues through a range of R&D activities designed to offer a set of solutions that shall benefit the Marine Core Service beyond 2015. The outcomes of the project are expected to benefit both the upstream and downstream services of the MCS. To achieve this, the OSS2015 team will conduct R&D work in three areas: o The derivation of 3-D and 4-D representations of biogeochemical variables from the integration of gliders and floats in situ data and EO satellite data into cutting-edge numerical biogeochemical and bio-optical models. The models, assimilation schemes and output products from the models will be tested at two pilot sites (Mediterranean and North Atlantic) o The generation and validation of satellite derived global time series of advanced biogeochemical products (POC, NPP, PFT, PSD) for carbon cycle science. o The implementation of a prototype platform of on-demand services for product generation and distribution. This system of services will be tested and demonstrated with the new biogeochemistry products developed during the project. OSS2015 will also analyse the social and economical benefits and value of the products and services generated by the project. The OSS2015 team is a good balance of ten partners from six scientific research institutions and four SMEs and is designed to cover the needs of both science users and users interested in more applied services. A strong emphasis will be put on dialogue and interaction with users in order to identify their actual needs and adapt the OSS2015 services accordingly whenever possible.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: ENV.2011.1.1.2-2 | Award Amount: 3.81M | Year: 2011

ECLIPSE aims to develop and assess effective emission abatement strategies for short-lived climate agents in order to provide sound scientific advice on how to mitigate climate change while improving the quality of air. Current climate policy does not consider a range of short-lived gases and aerosols, and their precursors (including nitrogen oxides, volatile organic compounds, sulphate, and black carbon). These nevertheless make a significant contribution to climate change and directly influence air quality. There are fundamental scientific uncertainties in characterizing both the climate and air quality impacts of short-lived species and many aspects (for example, the regional dependence) are quite distinct to those for the longer-lived climate gases already included in the Kyoto Protocol. ECLIPSE will bring together 11 institutes with established and complementary expertise for a closely co-ordinated 3 year programme. It will build on existing knowledge and use state-of-the-art chemistry and climate models to (i) improve understanding of key atmospheric processes (including the impact of short-lived species on cloud properties) and characterize existing uncertainties; (ii) evaluate model simulations of short-lived species and their long-range transport using ground-based and satellite observations; (iii) perform case studies on key source and receptor regions (focused on Southeastern Europe, China and the Arctic); (iv) quantify the radiative forcing and climate response due to short-lived species, incorporating the dependence on where the species are emitted; (v) refine the calculation of climate metrics, and develop novel metrics which, for example, consider rate of climate warming and go beyond using global-mean quantities; (vi) clarify possible win-win and trade-off situations between climate policy and air quality policy; (vii) identify a set of concrete cost-effective abatement measures of short-lived species with large co-benefits.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: ENV.2008. | Award Amount: 6.55M | Year: 2009

The broad interdisciplinary consortia assembled in the Arctic Tipping Points (ATP) project will be managed (WP1) to identify the elements of the Arctic marine ecosystem likely to show abrupt changes in response to climate change, and establish the levels of the corresponding climate drivers inducing the regime shift for these tipping elements. ATP will evaluate the consequences of crossing those tipping points, and the associated risks and opportunities for economic activities dependent on the Arctic marine ecosystem. Historical records of Arctic climate change and projections of future changes in Arctic sea climate and ice systems are compiled (WP2), and time series of Arctic ecosystem components analysed using novel statistical tools to detect regime shifts and ecological thresholds and tipping points, and evaluate their sensitivity to climatic forcing (WP3). Experimental manipulations and comparative analyses across broad climatic ranges will be used to detect climatic thresholds and tipping points of Arctic organisms and ecosystems, using genome-wide analyses to develop genomic markers of climate-driven stress useful as early-warning indicators of the proximity of tipping points (WP4). A biological-physical coupled 3 D model will be used to generate future trajectories of Arctic ecosystems under projected climate change scenarios and to identify their consequences for the Arctic ecosystem (WP5). The impacts of abrupt changes in the Arctic ecosystems for activities of strategic importance for the European Arctic and the associated impacts on employment and income will be elucidated, and policies and legislative frameworks to adapt and mitigate these impacts will be analysed (WP 6). The effectiveness of possible alternative, post-Kyoto policies and stabilization targets in avoiding climate-driven thresholds in the Arctic ecosystem will be examined, and the results and projections will be conveyed to policy makers, economic sectors and the public in general (WP7).

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.2.1 | Award Amount: 4.19M | Year: 2013

The aim of CoDyCo is to advance the current control and cognitive understanding about robust, goaldirected\nwhole-body motion interaction with multiple contacts. CoDyCo will go beyond traditional approaches: (1) proposing methodologies for performing coordinated interaction tasks with complex systems; (2) combining planning and compliance to deal with predictable and unpredictable events and contacts; (3) validating theoretical advances in real-world interaction scenarios.\nFirst, CoDyCo will advance the state-of-the-art in the way robots coordinate physical interaction and\nphysical mobility. Traditional industrial applications involve robots with limited mobility. Consequently,\ninteraction (e.g. manipulation) was treated separately from whole-body posture (e.g. balancing), assuming\nthe robot firmly connected to the ground. Foreseen applications involve robots with augmented autonomy\nand physical mobility. Within this novel context, physical interaction influences stability and balance. To\nallow robots to surpass barriers between interaction and posture control, CoDyCo will be grounded in\nprinciples governing whole-body coordination with contact dynamics.\nSecond, CoDyCo will go beyond traditional approaches in dealing with all perceptual and motor aspects\nof physical interaction, unpredictability included. Recent developments in compliant actuation and touch\nsensing allow safe and robust physical interaction from unexpected contact including humans. The next\nadvancement for cognitive robots, however, is the ability not only to cope with unpredictable contact, but\nalso to exploit predictable contact in ways that will assist in goal achievement.\nThird, the achievement of the project objectives will be validated in real-world scenarios with the iCub\nhumanoid robot engaged in whole-body goal-directed tasks. The evaluations will show the iCub exploiting\nrigid supportive contacts, learning to compensate for compliant contacts, and utilizing assistive physical\ninteraction.

Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.92M | Year: 2015

The proposed ITN entitled Modelling and computation of Shocks and Interfaces will focus on the training of young researchers in the general area of nonlinear hyperbolic and convection dominated PDEs with emphasis on innovative modelling and computational methods. The research program of the proposed ITN is centered on an important field (in terms of both history and scope), that is placed at the forefront of modern Computational and Applied Mathematics. The fact that hyperbolic convection dominated PDEs is probably one of the very few areas within Computational and Applied Mathematics, where traditionally modelling, Physics, Mechanics, analytical approaches, and advanced computational methods have contributed in synergy to several achievements to date, makes this field eminently suitable to train young researchers in. These researchers can become research leaders in a wide area as well as impacting on both industry and non-academic scientific institutions. The network will consist of some of Europes leading research groups on hyperbolic PDEs, and includes experts on Modelling, Analysis and Computation. A well defined training program is outlined in the proposal. The training program emphasises the European and international dimension of the effort. The training design is expected to produce effective results and foster the expertise on how to structure doctoral training at the European level and enhance the innovation capacity of the involved individuals. The innovative techniques developed will be applied to diverse concrete problems ranging from fluid dynamics and geophysical flows to materials science. In the pursuance of this goal, the research groups will be assisted by experts in these areas of application and non-academic partners, resulting in a significant enhancement of the impact of the research and training program.

Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.23M | Year: 2015

Demand for highly trained scientists with a deep understanding of wave propagation in complex media, and capable of exploiting this knowledge to develop imaging tools for seismology and acoustics, is very high in the Earth and environmental sciences. Wave-based imaging serves to map spatial and temporal variations in the structure of the Earths interior, of the oceans and atmosphere; it is used to monitor faults and volcanoes and detect natural-resource reservoirs. It is relevant to other disciplines, medical imaging being one of its most widespread applications. Todays Earth scientists are faced with a set of questions that require the application of wave-based imaging at unprecedented resolution. WAVES aims at fostering scientific and technological advances in this context, stimulating knowledge exchange between seismologists and acousticians, and researchers in the public/private domains. A unique strength of our network resides in the participation of novel physical acoustics laboratories, managed by beneficiaries/partners of WAVES, with a strong record of experimental research on inter-disciplinary and seismology-related topics. WAVES will train young scientists working in academia or industry in how to use this resource effectively, re-introducing the laboratory into the ideas-to-applications pipeline. Experimental work will serve to develop new theory, addressing topics of current interest such as acoustic time-reversal, scattering-based imaging. A truly multidisciplinary network, WAVES will apply these new ideas in a number of contexts: medical elastography is used as a tool to implement novel analogue models of seismic faults; wave sources are localized by a bio-inspired system making use of very few receivers, etc. Through WAVES, a critical mass of expertise will consolidate, defining the study of acoustic/elastic wave propagation and wave-based imaging/monitoring as an independent discipline, rich in applications of intellectual and societal relevance.

Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-EJD | Phase: MSCA-ITN-2014-EJD | Award Amount: 3.79M | Year: 2015

Theoretical Chemistry and Computational Modelling (TCCM) is emerging as a powerful tool to help in the rational design of new products and materials for pharmaceutical, chemical, energy, computer, and new-materials industries. To achieve this goal, it is necessary to go beyond the traditional electronic structure studies, and merge complementary techniques that are normally not available at a single research group. The research programme of the TCCM-EJD aims at applying computational modelling to problems demanded by the industry and with high societal relevance, namely Materials with special properties, Biomolecules for new therapies and Energy storage. The objective of the Joint Doctorate is to prepare future research leaders, able to develop and use multidisciplinary computational techniques (methods and software), with solid communication skills, with many contacts established through the intensive relationship with worldwide leading researchers of 12 European universities and 14 additional partners, including 7 industrial and spin-off companies. A Joint Doctorate in TCCM is already operative since 2011, based on a fully participative scientific discussion and assessment of all research projects with a clear interdisciplinary character and the direct participation of the non-academic sector. The training programme puts the emphasis in common training, including 3 annual International Workshops, 3 schools on High Performance Computing and 3 tutorials in new computer codes. Career development opportunities are enhanced with regular inter-sectoral activities, transferable skill education and career coaching.

Agency: Cordis | Branch: H2020 | Program: IA | Phase: ICT-12-2015 | Award Amount: 2.16M | Year: 2015

EMBERS will bring to market a back-end for smart city mobility that is developed by a European small enterprise based upon its smart parking and smart traffic management products that two municipalities in Portugal currently deploy. The Mobility Back-end as a Service (MBaaS) replaces such all-in-one systems, in which a municipality purchases the full set of components from a single vendor. Instead, the city manager can purchase best-of-breed devices and apps developed by third parties, with the only constraint being that they interoperate with the back-end via a free, open, smart city mobility API. This domain-specific API lowers barriers to entry for app and device developers, making it easier for innovative SMEs to enter the market. Furthermore, the API is offered via a variety of generic interfaces, including oneM2M, ETSI M2M, OMA LWM2M, and FIWARE NGSI. EMBERS thus clears the way for developers and to municipalities that have adopted any one of these potential emerging machine-to-machine (M2M) communication standards. Beyond its primary goal of bringing the MBaaS to market, EMBERS will stimulate development of an entire ecosystem around the MBaaS smart city mobility API. Separating out the back-end from the other components will, however, require rigorous testing. EMBERS will experiment with the system on two testbeds that are part of the FIRE\ OneLab facility: the FUSECO Playground, for M2M communications, and FIT IoT-LAB, for wireless sensor devices. EMBERS will host a hackathon and an app challenge to bring in third party developers. The project will also include three demonstrators by third parties via an open call. These activities will contribute back to FIRE\ by demonstrating successful experimentation by SMEs developing close-to-market products. The project will also conduct real world pilots in two or more cities as a final step in bringing the MBaaS to market.

Agency: Cordis | Branch: H2020 | Program: CSA | Phase: INFRADEV-2-2015 | Award Amount: 975.52K | Year: 2015

EMBRC is a distributed infrastructure of marine biology and ecology, encompassing aquaculture and biotechnology, exploiting the latest omics, analytical and imaging technologies, and providing on site and remote scientific and technical services to the scientific community of the public and private sector. EMBRC successfully completed a preparatory phase in early in 2014 with the production of a business plan and a memorandum of understanding (MoU) signed by 9 countries. A host for its headquarters has been chosen and and an ERIC application is in preparation. Since only institutions from 5 MoU signatory countries went through the preparatory phase, the present proposal has as objectives: 1) to harmonize the access mechanism to the operational EMBRC-ERIC across all the partners, putting all the practical tools in place, including host contracts and single point online access platform, to enable EMBRC-ERIC to commence its access program; 2) to put in place practical guidelines towards the full implementation of the new European and international legislation and commitments on access and fair benefit sharing of the use of marine biological resources, thus providing clarity to future users of EMBRC-ERIC about their legal rights over obtained biological resources, and positioning itself globally as a broker between users and the supplying countries ; 3) to focus the smart specialization of the regions onto the opportunities marine biological resources offer for blue-biotech development and innovation, thus demonstrating the member states that EMBRC is a tool towards economic development of their maritime regions, and enticing them to sign the EMBRC-ERIC, and prioritize its sustained support, particularly from regions which are now underrepresented in EMBRC (Black and Baltic Seas). These activities will ensure that the beneficiary research communities can exploit the results obtained at EMBRC-ERIC facility from the start with the highest efficiency.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.10.1.3 | Award Amount: 1.56M | Year: 2011

In the last two decades networks, and especially the Internet, have become part of the critical infrastructure of governments, businesses, homes and schools. The current Internet architecture, designed about 30 years ago, has suffered many extensions in recent years, to include new functionalities, which were unforeseen in the original design. Many network experts now consider it is necessary to undertake the study of alternative architectures for the Future Internet as a truly effective way to resolve many of the pressing problems that currently afflict the Internet.\n\nHowever, one serious obstacle to effective adoption of such innovations has been the inability to validate them convincingly. The reduction in real-world impact of any given network innovation is due to the enormous installed base of equipment and protocols, and the reluctance to experiment with production traffic, which have created an exceedingly high barrier to entry for new ideas. The result is that most new ideas from the networking research community go untried and untested, leading to the commonly held belief that the Internet infrastructure has ossified.\n\nHaving recognized the problem, the network research community is developing alternative solutions for experimental FI research, using programmable testbed networks such as those of GENI in the USA, AKARI in Japan and FIRE in Europe. The main goal of the FIBRE project is the design, implementation and validation of a shared Future Internet research facility between Brazil and Europe, supporting the joint Future Internet experimentation of European and Brazilian researchers. In order to achieve this goal the project will carry out four main activities:\n\tThe development and operation of a new experimental facility in Brazil, including the setup of equipment to support experimentation with various technologies (fixed layer 2 and layer 3, wireless, optical) as well as the design and implementation of a control framework to automate the use and operation of the testbed.\n\tThe development and operation of a Future Internet facility in Europe based on enhancements and the federation (interoperability) of two existing FIRE infrastructures: OFELIA and OneLab. Two of the OFELIA testbeds (i2CAT and UEssex) and the UTHs NITOS testbed will be enhanced by i) adding more physical resources to be able to cope with a bigger number of users and different use cases, ii) improving its respective control frameworks and iii) adding more manpower to operate the facilities.\n\tThe federation of the Brazilian and European experimental facilities, both at the physical connectivity and control framework level, to support the provisioning of slices using resources from both testbeds. This work will allow FIBRE experimenters to use the FIBRE facility as a unified, intercontinental testbed.\n\tThe design and implementation of pilot applications of public utility that showcase the power of a shared Europe-Brazil Future Internet experimental facility.

Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: INFRA-2008-1.2.2 | Award Amount: 3.39M | Year: 2009

Many research groups and institutes within the European Research Area (ERA) are playing a central role in the production of a vast range of atomic and molecular (AM) data, data that is of critical importance across a wide range of applications such as astrophysics, atmospheric physics, fusion, environmental sciences, combustion chemistry and in industrial applications from plasmas to lighting.\n\nThrough the auspices of this infrastructure the Virtual Atomic and Molecular Data Centre (VAMDC) aims to build a secure, documented, flexible and interoperable e-science environment-based interface to the existing AM data. The VAMDC will be built upon the expertise of existing AM databases, data producers and service providers with the specific aim of creating an infrastructure that is easily tuned to the requirements of a wide variety of users in academic, governmental, industrial or public communities both within and outside the ERA. The project will cover the building of the core consortium, the development and deployment of the infrastructure and the development of interfaces to the existing AM databases as well as providing a forum for training potential users and dissemination of expertise across the ERA. It is expected that VAMDC becomes a European legal entity during the course of the project.

Agency: Cordis | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses ICT to integrate neuroscience data from around the world, to develop a unified multi-level understanding of the brain and diseases, and ultimately to emulate its computational capabilities. The goal is to catalyze a global collaborative effort. During the HBPs first Specific Grant Agreement (SGA1), the HBP Core Project will outline the basis for building and operating a tightly integrated Research Infrastructure, providing HBP researchers and the scientific Community with unique resources and capabilities. Partnering Projects will enable independent research groups to expand the capabilities of the HBP Platforms, in order to use them to address otherwise intractable problems in neuroscience, computing and medicine in the future. In addition, collaborations with other national, European and international initiatives will create synergies, maximizing returns on research investment. SGA1 covers the detailed steps that will be taken to move the HBP closer to achieving its ambitious Flagship Objectives.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2007-2.2.2-3 | Award Amount: 15.91M | Year: 2008

The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of biological age and predict the onset of age-related diseases and/or residual lifetime are termed biomarkers of ageing. Many candidate biomarkers have been proposed but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has so far proven to yield a useful biomarker of ageing on its own, probably due to the multi-causal and multi-system nature of ageing. We propose to conduct a population study (3,300 probands) to identify a set biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. Two large groups of subjects will be recruited, i.e. (1) randomly recruited age-stratified individuals from the general population covering the age range 35-74 years and (2) subjects born from a long-living parent belonging to a family with long living sibling(s) already recruited in the framework of the GEHA project. For genetic reasons such individuals (GEHA offspring) are expected to age at a slower rate. They will be recruited together with their spouses as controls, thus allowing initial validation of the biomarkers identified. (3) A small number of patients with progeroid syndromes will also be included in the study. A wide range of candidate biomarkers will be tested, including (a) classical ones for which data from several smaller studies have been published; (b) new ones, based on recent preliminary data, as well as (c) novel ones, based on recent research on mechanistic aspects of ageing, conducted by project participants. Bioinformatics will be used in order to extract a robust set of biomarkers of human ageing from the large amounts of data to be generated and to derive a model for healthy ageing.

Agency: Cordis | Branch: FP7 | Program: NOE | Phase: ICT-2007.2.1 | Award Amount: 7.78M | Year: 2008

PASCAL2 builds on the FP6 PASCAL Network of Excellence that has created a distributed institute pioneering principled methods of pattern analysis, statistical modeling, and computational learning (see While retaining some of the structuring elements and mechanisms (such as the semi-annual Themes, and the Pump-Priming and Challenges programmes) of its predecessor NoE, PASCAL2 refocuses the institute towards the emerging challenges created by the ever expanding applications of adaptive systems technology and their central role in the development of artificial cognitive systems of different scales. Learning technology is key to, for instance, making robots more versatile, effective and autonomous, and to endowing machines with advanced interaction capabilities. The PASCAL2 Joint Programme of Activities (JPA) responds to these challenges not only through the research topics it addresses but also by engaging in technology transfer through an Industrial Club to effect rapid deployment of the developed technologies into a wide variety of applications. In addition, its Harvest sub-programme provides opportunities for close collaboration between academic and industry researchers. Other noteworthy outreach activities include curriculum development, brokerage of expertise, public outreach, and liaison with relevant R&D projects. Furthermore, PASCAL2 has adopted an open membership policy allowing for active inclusion in Network activities, of researchers working at non-beneficiary institutions.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.8.2 | Award Amount: 9.14M | Year: 2010

The overall objectives of the AQUTE project are\nA) To develop quantum technologies based on atomic, molecular and optical (AMO) systems for\n* scalable quantum computation;\n* entanglement-enabled technologies like metrology and sensing.\nB) To establish and exploit new interdisciplinary connections, coming from AMO physics, but also including concepts and experimental settings of solid state systems, in order to\n* reinforce interdisciplinary links at the frontiers of quantum information science, and other fields of physics or science in general;\n* conceive and realize novel hybrid systems that couple in a coherent way physically different quantum degrees of freedom.\nObj. A will be pursued along two complementary directions:\n* a bottom-up approach, where individually trapped atomic particles are combined into elementary general-purpose quantum processors including qubit interconnects;\n* a top-down approach, where many-particle atomic systems are employed to realize special-purpose quantum processors, for instance quantum simulators.\nGroundbreaking work in qualitatively new directions is also needed to lay the foundations for the future attainment of scalable fault-tolerant architectures. AQUTE will thus also\n* investigate new experimental systems that have become available in the laboratory and are of direct relevance for QIFT;\n* optimize existing and develop novel theoretical concepts for quantum processing.\nObj. B connects atomic quantum technologies for QIFT to a wider context, by\n* exploring hybrid approaches to QIFT beyond AMO physics;\n* improving connections between QIFT and science in general, following the emergence of a new quantum paradigm at the frontier of nanosciences and information sciences.\nThese research lines determine the structuring of the AQUTE workplan into four deeply interrelated Sub-Projects: Entangling gates and quantum processors, Hybrid quantum systems and interconnects, Quantum Simulators and Quantum Technologies.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRADEV-4-2014-2015 | Award Amount: 9.04M | Year: 2015

Marine (blue) biotechnology is the key to unlocking the huge economic potential of the unique biodiversity of marine organisms. This potential remains largely underexploited due to lack of connectivity between research services, practical and cultural difficulties in connecting science with industry, and high fragmentation of regional research, development and innovation (RDI) policies. To overcome these barriers, EMBRIC (European Marine Biological Resource Infrastructure Cluster) will link biological and social science research infrastructures (EMBRC, MIRRI, EU-OPENSCREEN, ELIXIR, AQUAEXCEL, RISIS) and will build inter-connectivity along three dimensions: science, industry and regions. The objectives of EMBRIC are to: (1) develop integrated workflows of high quality services for access to biological, analytical and data resources, and deploy common underpinning technologies and practices; (2) strengthen the connection of science with industry by engaging companies and by federating technology transfer (TT) services; (3) defragment RDI policies and involve maritime regions with the construction of EMBRIC. Acceleration of the pace of scientific discovery and innovation from marine bioresources will be achieved through: (i) establishment of multidisciplinary service-oriented technological workflows; (ii) joint development activities focusing on bioprospection for novel marine natural products, and marker-assisted selection in aquaculture; (iii) training and knowledge transfer; (iv) pilot transnational access to cluster facilities and services. EMBRIC will also connect TT officers from contrasted maritime regions to promote greater cohesion in TT practices. It will engage with policy-makers with the aim of consolidating a perennial pan-European virtual infrastructure cluster rooted in the maritime regions of Europe and underpinning the blue bioeconomy.

Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra-PP | Phase: INFRA-2010-2.2.5 | Award Amount: 5.29M | Year: 2011

The Preparatory Phase for a pan-European MARINE BIOLOGICAL RESOURCE CENTRE(EMBRC) research Infrastructure. This application focuses on the technical, legal, governance, and financial issues to prepare a memorandum of understanding to begin to construct EMBRC. It will build on existing Marine Biological Institutes and Research Centres which will be complemented with innovative components and properly embedded into European scientific, ethical, legal and societal frameworks. The preparative phase of EMBRC will provide the proof of concepts for a key resource to increase excellence and efficacy in Marine Biological Research and secure competitiveness of European research and industry in a global context. This distributed pan-European infrastructure will provide access to model marine organisms and related genomic resources. It will promote access for both research and training. The main costal marine laboratories will be embedded within this RI to provide access to model marine organisms and their ecosystems together with modern technology and omic platforms.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.3.3 | Award Amount: 5.16M | Year: 2011

Systems of Systems (SoS) are heterogeneous whereby the functionality more and more rely on the interaction and interoperability between the analogue/mixed-signal (AMS), digital electronics, software and other physical domains.\nTo achieve the required reliability, robustness and quality of SoS, mastering the heterogeneous behaviour across domains is the most essential part during the development process. The traditional barriers between different design disciplines such as system design, verification and prototype validation should be removed, by introducing an integral system verification and validation methodology.\nVerdi aims at improving the design efficiency and quality by developing methods and tools to address the design challenges related to heterogeneous integration. It will link simulation-based, pre-tape-out system analysis and verification with system validation and analysis of the physical prototype using measurement equipment, by:\n\tDefining an unified system-level verification and validation methodology\n\tSpecifying a Reuse strategy for verification IP, across and inside companies and for different product generations\n\tDefining a path from verification IP to validation IP, to bridge the gap between verification and prototype validation\nThe unified system-level verification library developed in Verdi will bring new concepts to continuously validate the SoS throughout the product creation process, based on methods to create and reuse verification components and IP such as stimuli, test-benches, analysis algorithms, etc.\nThe Verdi methodology and library will demonstrate for safety critical automotive SoS applications: power-train, in-vehicle networking and airbag.\nAs the methodology and library will extend industry-recognized standards (Universal Verification Methodology, SystemC and IP-XACT) they will be actively brought to standardization (Accellera, OSCI), enabling promotion and wider adoption in the industry in other heterogeneous applications.

SAS Institute, University Pierre, Marie Curie and French National Institute for Agricultural Research | Date: 2012-12-13

Phytoecdysones for use in improving muscle quality in obese and/or sarcopenic mammals, preferably, obese mammals subjected to a low-calorie diet. The phytoecdysones are advantageously incorporated into a food composition. The phytoecdysones can be derived from plants, such as quinoa.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SC1-PM-06-2016 | Award Amount: 23.70M | Year: 2017

A highly effective malaria vaccine against Plasmodium falciparum should help prevent half a million deaths from malaria each year. New vaccine technologies and antigen discovery approaches now make accelerated design and development of a highly effective multi-antigen multi-stage subunit vaccine feasible. Leading malariologists, vaccine researchers and product developers will here collaborate in an exciting programme of antigen discovery science linked to rapid clinical development of new vaccine candidates. Our approach tackles the toughest problems in malaria vaccine design: choice of the best antigens, attaining high immunogenicity, avoiding polymorphic antigens and increasing the durability of vaccine immunogenicity and efficacy. We take advantage of several recent advances in vaccinology and adopt some very new technologies: sequencing malaria peptides eluted from the HLA molecules, parasites expressing multiple transgenes, multi-antigen virus-like particles constructed with new bonding technologies, delayed release microcapsules, and liver-targeted immunisation with vaccine vectors. We enhance our chances of success by using a multi-stage multi-antigen approach, by optimising the magnitude and durability of well-characterised immune responses to key antigens, and using stringent infectious challenges and functional assays as established criteria for progression at each stage. The consortium comprises many of the foremost researchers in this field in Europe with leading groups in the USA, Australia and Africa. We link to EDCTP programmes and harmonise our timeline to fit with the recent roadmaps for malaria vaccine development. We include a major pharma partner and several excellent European biotech companies helping enhance Europes leading position in the commercial development of vaccines. This ambitious and exciting programme should have a high chance of success in tackling the major global health problem posed by malaria.

Agency: Cordis | Branch: H2020 | Program: ERC-STG | Phase: ERC-2016-STG | Award Amount: 1.50M | Year: 2017

Tryptophan (Trp) is an essential amino acid required for protein biosynthesis and is also a biochemical precursor of metabolites which have major effects on mammalian physiology. In the gastrointestinal tract, Trp metabolism can follow three major pathways, all of which are under the control of the gut microbiota: (i) the kynurenin pathway in immune and epithelial cells via indoleamine 2,3-Dioxygenase 1, (ii) the serotonin production pathway in enterochromaffin cells via Trp hydroxylase 1 and (iii) the direct use of Trp by the microorganisms of the gut microbiota into several molecules including ligands of the Aryl Hydrocarbon Receptor. The end products of these pathways play key roles in modulating the immune response, intestinal and metabolic functions and behaviour. Several diseases which involve the gut microbiota in their pathogenesis are also impacted by Trp metabolite. This suggests that the effect of the microbiota in these diseases could be at least partially mediated by impaired Trp metabolism. We recently observed that impaired Trp metabolism by the gut microbiota is involved in inflammatory bowel disease pathogenesis and preliminary data suggest a potential role in other major human diseases. The aims of the current proposal are (i) to identify the components of the gut microbiota, including both bacteria and fungi, involved in the control of the 3 Trp metabolism pathways in the gut, (ii) to decipher the reciprocal equilibrium between the pathways and to evaluate the potential of its modulation as a therapeutic target, and finally (iii) to assess the relevance of these phenomena in human patients. This challenging project will involve multi-disciplinary aspects, from microbiology to metabolism, inflammation and medicine, the use of multiple cutting edge technologies and translational analysis from mice to human. Beside scientific importance, it will have societal impact by identifying new therapeutic strategies in several human diseases with unmet needs.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-13-2016 | Award Amount: 11.65M | Year: 2017

The Fed4FIRE\ project has the objective to run and further improve Fed4FIREs best-in-town federation of experimentation facilities for the Future Internet Research and Experimentation initiative. Federating a heterogeneous set of facilities covering technologies ranging from wireless, wired, cloud services and open flow, and making them accessible through common frameworks and tools suddenly opens new possibilities, supporting a broad range of experimenter communities covering a wide variety of Internet infrastructures, services and applications. Fed4FIRE\ will continuously upgrade and improve the facilities and include technical innovations, focused towards increased user satisfaction (user-friendly tools, privacy-oriented data management, testbed SLA and reputation, experiment reproducibility, service-level experiment orchestration, federation ontologies, etc.). It will open this federation to the whole FIRE community and beyond, for experimentation by industry and research organisations, through the organization of Open Calls and Open Access mechanisms The project will also establish a flexible, demand-driven framework which allows test facilities to join during the course of its lifetime by defining a set of entry requirements for new facilities to join and to comply with the federation. FIRE Experimental Facilities generate an ever increasing amount of research data that provides the foundation for new knowledge and insight into the behaviour of FI systems. Fed4FIRE\ will participate in the Pilot on Open Research Data in Horizon 2020 to offer open access to its scientific results, to the relevant scientific data and to data generated throughout the projects lifetime. Fed4FIRE\ will finally build on the existing community of experimenters, testbeds and tool developers and bring them together regularly (two times a year) in engineering conferences to have maximal interaction between the different stakeholders involved.

French National Institute for Agricultural Research, University Pierre, Marie Curie and Institute Of Recherche Pour Le Developpement Ird | Date: 2013-10-17

The present invention relates to a method for determining whether an overweight subject has a reduced gut bacterial diversity. The said method comprises detecting the presence or absence in a gut DNA sample of at least one gene of at least one bacterial species of Table 1 or Table 2, respectively.

Prost J.,University Pierre and Marie Curie | Prost J.,National University of Singapore | Julicher F.,Max Planck Institute for the Physics of Complex Systems | Joanny J.-F.,University Pierre and Marie Curie | Joanny J.-F.,Paris West University Nanterre La Défense
Nature Physics | Year: 2015

The mechanical behaviour of cells is largely controlled by a structure that is fundamentally out of thermodynamic equilibrium: a network of crosslinked filaments subjected to the action of energy-transducing molecular motors. The study of this kind of active system was absent from conventional physics and there was a need for both new theories and new experiments. The field that has emerged in recent years to fill this gap is underpinned by a theory that takes into account the transduction of chemical energy on the molecular scale. This formalism has advanced our understanding of living systems, but it has also had an impact on research in physics per se. Here, we describe this developing field, its relevance to biology, the novelty it conveys to other areas of physics and some of the challenges in store for the future of active gel physics. © 2015 Macmillan Publishers Limited.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2009-2.4.4-1 | Award Amount: 8.18M | Year: 2010

Usher syndrome (USH) is the most frequent hereditary cause of deafness associated to blindness. It is a rare disease, affecting 1 in every 10.000 individuals, with an autosomal recessive monogenic inheritance. Deafness is congenital while the retinitis pigmentosa is not detected before the age of 8 to 10. These patients suffer from a dreadful disability as their two major senses are impaired. Important scientific advances have been achieved, mostly by auditory scientists: 9 causative genes have been identified. The hearing impairment pathogenesis has been elucidated, ie, an early developmental defect of auditory sensory cells. Our project gathering scientists and physicians from both the auditory and visual fields aims : -to halt the no longer acceptable underdiagnosis of this syndrome. Because, children affected with Usher type I, the most severe form, are usually diagnosed as severely or profoundly deaf only, parents may choose visual/sign language whereas these children would have taken full advantage from an early cochlear implantation. -To make these patients benefit from gene replacement therapy in the retina that recently showed tremendous results. We propose : 1/ To develop new clinical and molecular tools and guidelines for an early diagnosis thereafter broadly disseminated. 2/To clarify the retinal pathogenesis of Usher syndrome (type I and II) by an unpreceding effort to generate animal and tissue models that will be characterised in depth by multidisciplinary investigations including innovative methods. Mouse, frog, pig in vivo models and cultured retinal explants will be used, as well as human retinal cultures. This will also provide the necessary tests to evaluate phenotype rescuing. 3/To prevent and treat the retinal defect by associated adenovirus (AAV) gene therapy. This includes optimisation of the gene transfer and selection of patients to lead to a clinical trial carried out for one or more Usher genes (USH1B, 1C, 1G & USH2D)

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: KBBE.2010.3.2-04 | Award Amount: 3.89M | Year: 2011

Monitoring the quality of drinking water is of paramount importance for public health. Water is not a commercial product but a heritage that must be protected, defended and treated as such (Water Framework Directive 2000/60/EC). The threat of waterborne diseases in Europe will predictably increase in the future as the human population increases and as a result of globalization and migration from non-EU countries and of climate change. Development of efficient, sensitive, robust, rapid and inexpensive tests to monitor various aspects of water quality represents an essential milestone within the strategy for control and prevention of diseases caused by waterborne pathogens and by algal toxins. Traditional methods for the detection of waterborne pathogens, based on cultivation, biochemical characterisation and microscopic detection are laborious and time-consuming; molecular biological tools have now greatly enhanced our ability to investigate biodiversity by identifying species and to estimate gene flow and distribution of species in time and space. AQUA aims to design and develop a universal microarray chip for the high-throughput detection in water of known and emerging pathogens (bacteria, viruses, protozoa and cyanobacteria) and to assess the water quality monitoring the presence of select bioindicators (i.e. diatoms). A chip able to detect cyanobacterial toxins will also be developed. These innovative molecular tools should be amenable to automation so that they could be deployed on moorings for routine semi-continuous monitoring of water quality. AQUA also aims to identify cyanophages potentially capable of controlling and mitigating the periodical blooming of toxic cyanobacteria in drinking water reservoirs. Overall, these innovative and cost efficient technologies will reduce energy requirements and improve performance of water treatment, and allow rapid management response to new situations brought about by environmental (including climatic) changes.

Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: ICT-2013.9.9 | Award Amount: 72.73M | Year: 2013

Understanding the human brain is one of the greatest challenges facing 21st century science. If we can rise to the challenge, we can gain profound insights into what makes us human, develop new treatments for brain diseases and build revolutionary new computing technologies. Today, for the first time, modern ICT has brought these goals within sight. The goal of the Human Brain Project, part of the FET Flagship Programme, is to translate this vision into reality, using ICT as a catalyst for a global collaborative effort to understand the human brain and its diseases and ultimately to emulate its computational capabilities. The Human Brain Project will last ten years and will consist of a ramp-up phase (from month 1 to month 36) and subsequent operational phases.\nThis Grant Agreement covers the ramp-up phase. During this phase the strategic goals of the project will be to design, develop and deploy the first versions of six ICT platforms dedicated to Neuroinformatics, Brain Simulation, High Performance Computing, Medical Informatics, Neuromorphic Computing and Neurorobotics, and create a user community of research groups from within and outside the HBP, set up a European Institute for Theoretical Neuroscience, complete a set of pilot projects providing a first demonstration of the scientific value of the platforms and the Institute, develop the scientific and technological capabilities required by future versions of the platforms, implement a policy of Responsible Innovation, and a programme of transdisciplinary education, and develop a framework for collaboration that links the partners under strong scientific leadership and professional project management, providing a coherent European approach and ensuring effective alignment of regional, national and European research and programmes. The project work plan is organized in the form of thirteen subprojects, each dedicated to a specific area of activity.\nA significant part of the budget will be used for competitive calls to complement the collective skills of the Consortium with additional expertise.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.3.1 | Award Amount: 6.25M | Year: 2012

From the strategic agendas of ENIAC,EPoSS and ITRS it is evident that wirelessapplications are gaining more and more importance that results to new requirements in terms of miniaturization and increased complexity.The limitations of Moores Law in term of physics but also in terms of manufacturability, flexibility and multi-functionality has motivated research and development to implement new technologiesand new wireless architectures identified as Beyond CMOS and More than Moore.Carbon nanotubes are featuring very attractive intrinsic multi-physic properties. These properties coupled with CMOS compatibility offer promise for a new generation of smart miniaturised systems for wireless communications.Graphene also exhibits impressive electrical and mechanical properties.CMOS compatible microwave graphene devices, still at their infancy, hold promise for extremely low noise and high speed communications.The coordinator (TRT) is one of the major world players in civilian & professional electronics.TAS is N1in Europe and N3 worldwide for civil and military aerospace products. One key area for their products is T/R front-end systems for applications like radars for which long term solutions are continuously sought after.The main concept of NANO-RF is the development of CNT&graphene based advanced component technologies for the implementation of miniaturised electronic systems for 2020 and beyond wirelesscommunications and radars.The major objectives of NANO-RF are the development of: Active components from CNTs&graphene Passive components from CNTs& grapheneCapacitive RF NEMS from CNTsCNTs based vertical interconnectsCNTs & graphene based ICsThe developed components and technologies will be implemented in the following demonstratorsReflect array antennae for wake vortex and weather radars and Graphene receiver moduleThe demonstrators will exhibit the reconfigurability, systemability, integratability and manufacturability of thedevelopedtechnologies and unify advanced

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: NMP-2007-1.1-2 | Award Amount: 5.00M | Year: 2008

Recent developments in the design and synthesis of nanoscale building blocks as active elements in opto- or bio-electronic devices with tailored electronic functionality have the potential to open up new horizons in nanoscience and also revolutionise multi-billion dollar markets across multiple technology sectors including healthcare, printable electronics, and security. Ligand-stabilised inorganic nanocrystals (~2-30 nm core diameters) and functional organic molecules are attractive building blocks due to their size dependent opto-electronic properties, the availability of low-cost synthesis processes and the potential for formation of ordered structures via (bio) molecular recognition and self-assembly. Harnessing the complementary properties of both nanocrystals and functional molecules thus represents a unique opportunity for generation of new knowledge and development of new classes of high knowledge-content materials with specific functionality tailored for key applications, e.g., printable electronics, biosensing or energy conversion in the medium term, and radically new information and signal processing paradigms in the long term. Self-assembly and self-organisation processes offer the potential to achieve dimensional control of novel multifunctional materials at length scales not accessible to conventional top-down technologies based on lithography. It is critical for European industry to develop new knowledge and low-cost, scaleable processes for assembly and electrical interfacing of these multifunctional materials with conventional contact electrodes in order to produce into tailored devices and products, in particular on low-cost substrates. The FUNMOL consortium will deliver substantial innovation to European industry via development of cost-effective, scaleable processes for directed assembly of high-knowledge content nanocrystal-molecule materials into electrically-interfaced devices at silicon oxide, glass and plastic substrates.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2013.6.1-1 | Award Amount: 12.17M | Year: 2013

Tropical Atlantic climate recently experienced pronounced shifts of great socio-economic importance. The oceanic changes were largest in the eastern boundary upwelling systems. African countries bordering the Atlantic strongly depend upon their ocean - societal development, fisheries, and tourism. They were strongly affected by these climatic changes and will face important adaptation challenges associated with global warming. Furthermore, these upwelling regions are also of great climatic importance, playing a key role in regulating global climate. Paradoxically, the Tropical Atlantic is a region of key uncertainty in earth-climate system: state-of-the-art climate models exhibit large systematic error, climate change projections are highly uncertain, and it is largely unknown how climate change will impact marine ecosystems. PREFACE aims to address these interconnected issues, and has the following goals: To reduce uncertainties in our knowledge of the functioning of Tropical Atlantic climate. To improve climate prediction and the quantification of climate change impacts in the region. To improve understanding of the cumulative effects of the multiple stressors of climate variability, greenhouse induced climate change, and fisheries on marine ecosystems, and ecosystem services (e.g., fisheries, coastal vulnerability). To assess the socio-economic vulnerabilities and evaluate the resilience of Atlantic African fishing communities to climate-driven ecosystem shifts and global markets. To meet these goals we bring together European and African expertise to combine regional and global scale modelling capabilities, field experiments and observation systems. Our target region includes areas more affected by climate change and by its consequences, European outermost regions, and African countries bordering the Atlantic.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: Fission-2007-1.2-01 | Award Amount: 23.78M | Year: 2008

Actinide recycling by separation and transmutation is considered worldwide and particularly in several European countries as one of the most promising strategies to reduce the inventory of radioactive waste, thus contributing to make nuclear energy sustainable. Consistently with potentially viable recycling strategies, the Collaborative Project ACSEPT will provide a structured R&D framework to develop chemical separation processes compatible with fuel fabrication techniques, with a view to their future demonstration at the pilot level. Considering technically mature aqueous separation processes, ACSEPT will optimise and select the most promising ones dedicated to actinide partitioning and those featuring a group separation. These developments will be appropriately balanced with an exploratory research focused on the design of new molecules. In parallel, promising group actinide separation pyro-processes will be developed beyond the current state-of-the-art, as an alternative option, for a longer term. ACSEPT will also pave the way towards more integration between Partitioning and Transmutation by carrying dissolution as well as actinide conversion studies. All experimental results will be integrated by carrying out engineering and systems studies on aqueous and dry (pyro) processes to prepare for future demonstration at a pilot level. A training and education programme will also be implemented to share the knowledge among partitioning community and present and future generations of researchers. The challenging objectives of ACSEPT will be addressed by a multi-disciplinary consortium composed of European universities, nuclear research bodies and major industrial players. This consortium will generate fundamental improvements for a future design of an Advanced Processing Pilot Unit. ACSEPT will thus be an essential contribution to the demonstration, in the long term, of the potential benefits of actinide recycling to minimise the burden on the geological repositories.

Agency: Cordis | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2012-IRSES | Award Amount: 520.80K | Year: 2013

The project European and Chinese Platform for Robotics and Applications (ECROBOT) focuses on the staff exchange between the partners of EU and China, and on the development of new technologies and applications in the field of robotics on the macro, micro and nano scales. It meets the objectives and requirements of the Marie Curie Action: International Research Staff Exchange Scheme (IRSES), by setting up multiple bridges between European and Chinese institutions. The ultimate goal of ECROBOT is to establish a long-term research cooperation platform between Europe and China in the challenging field of Robotics with promising applications in scientific, industrial and domestic sectors. The synergistic approach made by ECROBOT will keep the consortiums leading position in the world for potential major scientific and technological breakthroughs. The project is divided into five inter-related workpackages: (1) Setup of knowledge base and road mapping, (2) Fundamental exploration of robotics, (3) Development of robot systems, (4) Dissemination and exploitation, and (5) Project management. The workpackages integrate all activities that will lead to the completion of all the project objectives within 36 months.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2010.2.3.2-2 | Award Amount: 8.47M | Year: 2011

Early stage Drug Discovery efforts over the last 5 years have resulted in the identification of a number of promising lead compounds in the fight against TB. These leads need to be further progressed and optimised into candidates for pre-clinical development through the Drug Development progression cascade. Three compound families are of particular interest: 1) InhA Inhibitors, 2) New potent whole cell anti-tubercular compounds with unknown mode of action and 3) new Beta-lactam/Beta-lactamase combinations for TB. A preclinical package is already in place for some of them, but further work is necessary for others in order to justify the progression of a single anti-tubercular family to the more resource intensive stages of preclinical and clinical development. The project will encompass the parallel progression of the three compound families through: A) Lead Optimization Chemistry efforts and MoA studies (Genetic and Proteomic) for whole cell inhibitors, B) In vitro and in vivo evaluation of a new orally bioavailable Beta-lactam alone or in combination with a Beta-lactamase inhibitor to evaluate the sterilising potential of the new drug/s and C) the optimization of an InhA inhibitor for later preclinical development. These efforts will yield candidate molecules for new information rich in vitro assays of antimycobacterial activity (artificial granuloma, activity against slow/non growing cells and activity against clinical isolates) as well as for in vivo safety and efficacy evaluation in different animal models of infection (acute and/or chronic). At this stage a single compound family will be prioritized. Further studies will be performed assessing the potential for shortening treatment in stand alone therapy as well as in combination regimens both in vitro and in vivo. Finally a Clinical Development plan will be put in place for the selected candidate molecule.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: ENV.2010.1.1.5-1 | Award Amount: 4.82M | Year: 2011

Increases of atmospheric CO2 and associated decreases in seawater pH and carbonate ion concentration this century and beyond are likely to have wide impacts on marine ecosystems including those of the Mediterranean Sea. Consequences of this process, ocean acidification, threaten the health of the Mediterranean, adding to other anthropogenic pressures, including those from climate change. Yet in comparison to other areas of the world ocean, there has been no concerted effort to study Mediterranean acidification, which is fundamental to the social and economic conditions of more than 130 million people living along its coastlines and another 175 million who visit the region each year. The MedSeA project addresses ecologic and economic impacts from the combined influences of anthropogenic acidification and warming, while accounting for the unique characteristics of this key region. MedSeA will forecast chemical, climatic, ecological-biological, and socio-economical changes of the Mediterranean driven by increases in CO2 and other greenhouse gases, while focusing on the combined impacts of acidification and warming on marine shell and skeletal building, productivity, and food webs. We will use an interdisciplinary approach involving biologists, earth scientists, and economists, through observations, experiments, and modelling. These experts will provide science-based projections of Mediterranean acidification under the influence of climate change as well as associated economic impacts. Projections will be based on new observations of chemical conditions as well as new observational and experimental data on the responses of key organisms and ecosystems to acidification and warming, which will be fed into existing ocean models that have been improved to account for the Mediterraneans fine-scale features. These scientific advances will allow us to provide the best advice to policymakers who must develop regional strategies for adaptation and mitigation.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2007.1.6 | Award Amount: 8.85M | Year: 2008

Experimentally driven research is key to success in todays Internet. Many test beds support research and development, and product prototyping in communication networks. However, they tend to specialise in particular access technologies or services, or explore near term product offerings, often with limited availability and openness. An open and sustainable large-scale shared experimental facility will allow European industry and academia to innovate today and to design the future Internet. The OneLab2 project will leverage the original OneLab projects PlanetLab Europe test bed and its international visibility to make this facility a reality.\n\nOneLab2 is built on three complementary pillars. The Platform Pillar will operate PlanetLab Europe, extending PlanetLab service across Europe, and federating with other PlanetLab infrastructures worldwide. It will integrate new features into the system. The Tools Pillar will enhance the test-bed-native network monitoring service that supports experiments. And the Customers Pillar will meet the needs of the facilitys customers by providing them with access to diverse facilities, achieved through federating different types of test bed. An experimental facility must know its customers. OneLab2 will do this by directly involving pilot customers who are testing novel ideas in networking research.\n\nOneLab2s coalition assembles some of the most highly respected networking research teams from university and industry labs in Europe. Each team has an active research agenda in new network technologies, network monitoring, or test bed management. OneLab2s success would mean that PlanetLab Europe is established as a competitive and federated facility with international visibility and a broad set of customers, implementing OneLab2s vision and research contributions. PlanetLab Europe will continue to function beyond the end of the project period, providing ongoing services to the research community at large.

Agency: Cordis | Branch: FP7 | Program: NOE | Phase: ICT-2011.1.6 | Award Amount: 5.99M | Year: 2011

The goal of EINS is coordinating and integrating European research aimed at achieving a deeper multidisciplinary understanding of the development of the Internet as a societal and technological artefact, whose evolution is increasingly interwined with that of human societies. Its main objective is to allow an open and productive dialogue between all the disciplines which study Internet systems under any technological or humanistic perspective, and which in turn are being transformed by the continuous advances in Internet functionalities and applications. EINS will bring together research institutions focusing on network engineering, computation, complexity, security, trust, mathematics, physics, sociology, game theory, economics, political sciences, humanities, law, energy, transport, artistic expression, and any other relevant social and life sciences.\nThis multidisciplinary bridging of the different disciplines may also be seen as the starting point for a new Internet Science, the theoretical and empirical foundation for an holistic understanding of the complex techno-social interactions related to the Internet. It is supposed to inform the future technological, social, political choices concerning Internet technologies, infrastructures and policies made by the various public and private stakeholders, for example as for the far-ended possible consequences of architectural choices on social, economic, environmental or political aspects, and ultimately on quality of life at large.\nThe individual contributing disciplines will themselves benefit from a more holistic understanding of the Internet principles and in particular of the network effect. The unprecedented connectivity offered by the Internet plays a role often underappreciated in most of them; whereas the Internet provides both an operational development platform and a concrete empirical and experimental model. These multi- and inter-disciplinary investigations will improve the design of elements of Future Internet, enhance the understanding of its evolving and emerging implications at societal level, and possibly identify universal principles for understanding the Internet-based world that will be fed back to the participating disciplines. EINS will:\nCoordinate the investigation, from a multi-disciplinary perspective, of specific topics at the intersection between humanistic and technological sciences, such as privacy & identity, reputation, virtual communities, security & resilience, network neutrality\nLay the foundations for an Internet Science, based i.a. on Network Science and Web Science, aiming at understanding the impact of the network effect on human societies & organisations, as for technological, economic, social & environmental aspects\nProvide concrete incentives for academic institutions and individual researchers to conduct studies across multiple disciplines, in the form of online journals, conferences, workshops, PhD courses, schools, contests, and open calls

Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: ENV.2008. | Award Amount: 1.81M | Year: 2009

The issue of concern of the AWARE project is the anthropogenic deterioration of water ecosystems, in particular in coastal areas. The new approach proposed by the AWARE project to enhance connectivity between research and policy-making exploit the concept of integrated adaptive ecosystem management, engaging scientists, policy makers and the public (the latter including both stakeholders and lay citizens/water users) into comparable case studies of participatory scenario-building. The emphasis given to the role of the public enlarges the concept of organisational learning to the wider concept of social learning. The specific objectives and WPs of the AWARE project will include therefore: WP1: to design and prepare the pilot experiments of participatory scenario-building; WP2: to perform three case studies of participatory-scenario building in different coastal regions of Europe; WP3: to make an evaluation and assessment of the pilot case studies and of the proposed approach; WP4: to foster networking between science institutions, policy authorities and stakeholders in the case study areas and at EU level, and disseminate the approach elsewhere in Europe. The AWARE consortium includes 14 partners of complementary expertise in the field of aquatic ecosystems studies (UU, UPMC, ULB, UNIPR), social sciences (ADELPHI, ICCR, Missions Publiques), system analysis (ISIS, JRC-IES, UNISI) and integrated water management (BIOFORSK, POLIEDRA), plus the Environmental Service from the Provincial Administration of Ferrara and the Baltic Environmental Forum (BEF). The consortium will be complemented by an advisory group of 10 policy makers and stakeholders.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: SPA-2007-1.1-01;SPA-2007-1.1-02 | Award Amount: 15.86M | Year: 2009

MACC (Monitoring Atmospheric Composition and Climate) is designed to meet the requirements that have been expressed for the pilot Core GMES Atmospheric Service. The project has been prepared by the consortia of the FP6 project GEMS and the GSE project PROMOTE, whose core service lines will provide the starting point for MACC. From mid-2009 MACC will continue, improve, extend, integrate and validate these service lines, so that the overall MACC system is ready near the end of 2011 for qualification as the operational GMES Atmospheric Core Service. MACC will prepare the core service in terms of implementation, sustained operation and availability. It will maintain and further develop the efficiency and resilience of the end-to-end pre-operational system, and will refine the scientific basis and quality of the products of the system. It will ensure that its service lines best meet both the requirements of downstream-service providers and end users at the European, national and local levels, and the requirements of the global scientific user community. The service lines will cover air quality, climate forcing, stratospheric ozone and solar radiation. MACC will deliver operational products and information that support the establishment and implementation of European policy and wider international programmes. It will acquire and assimilate observational data to provide sustained real-time and retrospective global monitoring of greenhouse gases, aerosols and reactive gases such as tropospheric ozone and nitrogen dioxide. It will provide daily global forecasts of atmospheric composition, detailed air-quality forecasts and assessments for Europe, and key information on long range transport of atmospheric pollutants. It will provide comprehensive web-based graphical products and gridded data on which downstream services may be based. Feedback will be given to space agencies and providers of in-situ data on the quality of their data and on future observational requirements.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2013.6.4-1 | Award Amount: 14.89M | Year: 2013

Assessing individual exposure to environmental stressors and predicting health outcomes implies that both environmental exposures and epi/genetic variations are reliably measured simultaneously. HEALS (Health and Environment-wide Associations based on Large population Surveys) brings together in an innovative approach a comprehensive array of novel technologies, data analysis and modeling tools that support efficiently exposome studies. The general objective of HEALS is the refinement of an integrated methodology and the application of the corresponding analytical and computational tools for performing environment-wide association studies in support of EU-wide environment and health assessments. The exposome represents the totality of exposures from conception onwards, simultaneously identifying, characterizing and quantifying the exogenous and endogenous exposures and modifiable risk factors that predispose to and predict diseases throughout a persons life span. The HEALS approach brings together and organizes environmental, socio-economic, exposure, biomarker and health effect data; in addition, it includes all the procedures and computational sequences necessary for applying advanced bioinformatics coupling thus effective data mining, biological and exposure modeling so as to ensure that environmental exposure-health associations are studied comprehensively. The overall approach will be verified and refined in a series of population studies across Europe including twin cohorts, tackling different levels of environmental exposure, age windows of exposure, and socio-economic and genetic variability. The HEALS approach will be applied in a pilot environment and health examination survey of children including singletons and sets of twins with matched singletons (each twins pair having also a matched singleton) covering ten EU Member States (the EXHES Study). The lessons learned will be translated into scientific advice towards the development of protocols and guidelines for the setting up of a larger European environment and health examination survey.

Agency: Cordis | Branch: H2020 | Program: CSA | Phase: ICT-37-2016 | Award Amount: 2.56M | Year: 2017

Europe and China are at the forefront of technological advances in areas related to the Future Internet (especially 5G and IoT). While both parties share common technological objectives, there is still room for improvement in what concerns bilateral co-operation. As a result, the main purpose of EXCITING is to support the creation of favourable conditions for co-operation between the European and Chinese research and innovation ecosystems, mainly related to the key strategic domains of IoT and 5G. EXCITING will study the research and innovation ecosystem for IoT and 5G in China and compare it with the European model. EXCITING will identify and document the key international standards bodies for IoT and 5G, as well as other associations and fora where discussions take place and implementation decisions are made. Going beyond standardisation, interoperability testing is a key step towards market deployment. EXCITING will identify and document the key international InterOp events at which European and Chinese manufacturers can test and certify their IoT and 5G products. It will also explain the rules for engaging in these events. EXCITING will produce Best Practice guidelines for establishing and operating practical joint collaborations, in order to stimulate further such co-operations in the future on IoT and 5G Large Scale Pilots. As a result of the above investigations EXCITING will produce a roadmap showing how research and innovation ecosystems, policy, standardisation, interoperability testing and practical Large Scale Pilots should be addressed during the H2020 timeframe, and make recommendations for optimising collaboration between Europe and China for IoT and 5G.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: ENV.2008. | Award Amount: 10.98M | Year: 2009

The HERMIONE project is designed to make a major advance in our knowledge of the functioning of deep-sea ecosystems and their contribution to the production of goods and services. This will be achieved through a highly interdisciplinary approach (including biologists, ecologists, microbiologists, biogeochemists, sedimentologists, physical oceanographers, modelers and socio-economists) that will integrate biodiversity, specific adaptions and biological capacity in the context of a wide range of highly vulnerable deep-sea habitats. Gaining this understanding is crucial, because these ecosystems are now being affected by climate change and impacted by man through fishing, resource extraction, seabed installations and pollution. To design and implement effective governance strategies and management plans we must understand the extent, natural dynamics and interconnection of ocean ecosystems and integrate socio-economic research with natural science. The study sites include the Arctic, North Atlantic and Mediterranean and cover a range of ecosystems including cold-water corals, canyons, cold and hot seeps, seamounts and open slopes and deep-basins. The project will make strong connections between deep-sea science and user needs. HERMIONE will enhance the education and public perception of the deep-ocean issues also through some of the major EU aquaria. These actions, together with GEOSS databases that will be made available, will create a platform for discussion between a range of stakeholders, and contribute to EU environmental policies.

Agency: Cordis | Branch: H2020 | Program: CSA | Phase: SPACE | Award Amount: 5.00M | Year: 2014

MACC-III is the last of the pre-operational stages in the development of the Copernicus Atmosphere Service. Its overall institutional objective is to function as the bridge between the developmental precursor projects - GEMS, PROMOTE, MACC and MACC-II- and the Atmosphere Service envisaged to form part of Copernicus Operations. MACC-III will provide continuity of the atmospheric services provided by MACC-II. Its continued provision of coherent atmospheric data and information, either directly or via value-adding downstream services, is for the benefit of European citizens and helps meet global needs as a key European contribution to the Global Climate Observing System (GCOS) and the encompassing Global Earth Observation System of Systems (GEOSS). Its services cover in particular: air quality, climate forcing, stratospheric ozone, UV radiation and solar-energy resources. MACC-IIIs services are freely and openly available to users throughout Europe and in the world. MACC-III and its downstream service sector will enable European citizens at home and abroad to benefit from improved warning, advisory and general information services and from improved formulation and implementation of regulatory policy. MACC-III, together with its scientific-user sector, also helps to improve the provision of science-based information for policy-makers and for decision-making at all levels. The most significant economic benefit by far identified in the ESA-sponsored Socio-Economic Benefits Analysis of Copernicus report published in July 2006 was the long-term benefit from international policy on climate change. Long-term benefit from air quality information ranked second among all Copernicus benefits in terms of present value. Immediate benefits can be achieved through efficiency gains in relation to current policies. The estimated benefits substantially outweigh the costs of developing and operating the proposed services.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: BG-08-2014 | Award Amount: 20.65M | Year: 2015

The overarching objective of AtlantOS is to achieve a transition from a loosely-coordinated set of existing ocean observing activities to a sustainable, efficient, and fit-for-purpose Integrated Atlantic Ocean Observing System (IAOOS), by defining requirements and systems design, improving the readiness of observing networks and data systems, and engaging stakeholders around the Atlantic; and leaving a legacy and strengthened contribution to the Global Ocean Observing System (GOOS) and the Global Earth Observation System of Systems (GEOSS). AtlantOS will fill existing in-situ observing system gaps and will ensure that data are readily accessible and useable. AtlantOS will demonstrate the utility of integrating in-situ and Earth observing satellite based observations towards informing a wide range of sectors using the Copernicus Marine Monitoring Services and the European Marine Observation and Data Network and connect them with similar activities around the Atlantic. AtlantOS will support activities to share, integrate and standardize in-situ observations, reduce the cost by network optimization and deployment of new technologies, and increase the competitiveness of European industries, and particularly of the small and medium enterprises of the marine sector. AtlantOS will promote innovation, documentation and exploitation of innovative observing systems. All AtlantOS work packages will strengthen the trans-Atlantic collaboration, through close interaction with partner institutions from Canada, United States, and the South Atlantic region. AtlantOS will develop a results-oriented dialogue with key stakeholders communities to enable a meaningful exchange between the products and services that IAOOS can deliver and the demands and needs of the stakeholder communities. Finally, AtlantOS will establish a structured dialogue with funding bodies, including the European Commission, USA, Canada and other countries to ensure sustainability and adequate growth of IAOOS.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: NMP-2009-2.6-1 | Award Amount: 4.09M | Year: 2010

More than 1.2 billion people, mostly in poor regions, suffer from water scarcity, due to a global shortfall of potable water caused by population growth, over-exploitation, and pollution. NATIOMEM proposes to alleviate this by developing novel technology for treating contaminated surface and waste water so that it will be potable. This technology will not require electrical power, chemicals or other logistical support, and hence will be suitable for poor areas lacking infrastructure. The technology uses membranes functionalized with a photocatalytic material, eg. N-doped TiO2 (TiON). Raw water will be directed through the membrane while it is exposed to solar radiation. The membrane will filter out particles and micro-organisms larger than the its pore size, and TiON photocatalysis will kill micro-organisms, decompose and mineralize organic pollutants, and oxidize dissolved metals, thus providing a one-step treatment against a broad spectrum of contaminants. In the NATIOMEM project, functionalized membranes will be developed with two approaches: (1) coating conventional membranes with TiON nanostructured films, using several candidate deposition methods, and (2) electrospinning TiON fibers, from which membranes will be fabricated. The functionalized membranes will be characterized for their morphological, physical, mechanical, chemical, and in particular, their photocatalytic properties, and the most effective will be extensively tested to determine their pollution abatement mechanisms and kinetics. A pilot plant incorporating these photocatalytic membranes will be designed, and field tested in the Middle East and in Africa. The results of these tests will be correlated with potential end-user requirements to set the stage for industrial exploitation. Achieving this result will be a breakthrough in water purification and reclamation technology, advancing far beyond the state of the art with a system which is simple, solar enabled, and chemical free.

Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2008-1.1.1 | Award Amount: 8.96M | Year: 2009

SPIRIT is an Integrating Activities project integrating 7 leading ion beam facilities and 4 research providers from 7 Member States and 1 Associated State. The 7 partners providing TransNational Access supply ions in an energy range from ~10 keV to 100 MeV for modification and analysis of solid surfaces, interfaces, thin films and nanostructured systems. The techniques cover materials, biomedical and environmental research and technology, and are complementary to the existing synchrotron and neutron radiation networks. The partners have highly complementary equipment and areas of specialization. SPIRIT will increase User access and the quality of research by sharing best practice, balancing supply and demand, harmonizing procedures and extending the services into new emerging fields and to new users especially from the NMS and industry. An independent International User Selection Panel will examine proposals under a common SPIRIT procedure. Networking activities include the development of common standards for quality assessment; training and consultancy for User researchers and foresight studies. Joint Research Activities will promote emerging fields such as targeted single ion implantation for irradiation of living cells; ion-beam based analysis with ultrahigh depth resolution; ion-based 3-D tomography, and chemical and molecular imaging. Joint efforts are necessary to improve the systems for detection of ion-induced secondary radiation and to develop means to reduce sample deterioration by the analyzing ion beam. Finally, a unified software package for ion-beam based analysis shall be developed and made available to the community. The management structure of SPIRIT will consist of a Management Board, 3 Activity Boards (Networking, Transnational Access and Joint Research) and a Project Steering Team. A European Users Panel will provide input on user needs, evaluate service improvements against the benchmark level and assess new capabilities resulting from the JRA.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: KBBE.2012.1.1-01 | Award Amount: 3.83M | Year: 2013

Seed quality is of paramount importance to agriculture, food security and the conservation of wild species. Considerable economic losses result from sub-optimal seed performance, undermining food security and livelihoods. Seed quality is strongly influenced by the environmental stresses experienced by the mother plant. Climate change will further exacerbate economic losses and decrease the predictability of seed yield and quality for the farmer. The looming challenges of climate change and food security require new knowledge of how stress impacts on seed quality, as well as a re-appraisal of optimal storage conditions. EcoSeed addresses these challenges by bringing together a group of distinguished European experts in seed science and converging sciences to characterise seed quality and resilience to perturbation. EcoSeed combines state-of the-art omics, epigenetics, and post-omics approaches, such as nuclear and chromatin compaction, DNA repair, oxidative and post-translational modifications to macromolecules, to define regulatory switchboards that underpin the seed phenotype. Special emphasis is placed on the stress signalling hub that determines seed fate from development, through storage, germination and seedling development, with a particular focus on seed after-ripening, vigour, viability and storability. Translation of new knowledge gained in model to crop and wild species is an integral feature of EcoSeed project design, which will create a step-change in our understanding of the regulatory switchboards that determine seed fate. Novel markers for seed quality and new omics information generated in this project will assist plant breeders, advise the seed trade and conservationists alike. In this way, EcoSeed will not only be proactive in finding solutions to problems of ensuring seed quality and storability but also play a leading role in enabling associated industries to better capture current and emerging markets.

The I-MOVE\ Consortium includes European Union (EU) Public Health Institutes, SME and Universities. It aims at measuring and comparing the effectiveness (VE) and impact (VI) of influenza and Pneumococcal vaccines and vaccination strategies a in the elderly population in Europe. The goal is to develop a sustainable platform of primary care practices, hospitals and laboratory networks that share validated methods to evaluate post marketing vaccine performances. The objectives are to identify, pilot test, and disseminate in EU the best study designs to measure, on a real time basis, VE (direct effect) and the VI of vaccination programmes (indirect and overall effect) against laboratory confirmed cases of influenza (types/subtypes) and pneumococcal disease (serotypes), and clinical outcomes. Cost effectiveness analysis will be conducted. Results will allow to understand factors affecting specific VE, the duration of protection of influenza and pneumococcal vaccines, the interaction between vaccines, the role of repeated vaccinations, the occurrence of serotype replacement (pneumococcus); identify vaccine types and brands with low VE; guide the decision of the WHO committees on vaccine strain selection (influenza); provide robust benefit indicators (VE and VI) and cost benefit and effectiveness results; guide vaccination strategies (schedules, doses, boosters). This EU member state collaboration will respond to questions that require studies based on large sample sizes and sharing of expertise that cannot be achieved by one country alone. It will allow the best methods to be used and results to benefit to all EU countries whatever their current public health achievements. Results will be shared with international partners.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: BG-03-2014 | Award Amount: 7.65M | Year: 2015

Microalgae are a source of secondary metabolites useful as new bioactive compounds. Activity of these compounds against bacterial pathogens and biofilm formation has not been determined yet. Biofilm formation is especially important in infections and tissue inflammation related to implants and catheters. These problems finally cause a release of the implant, which must be removed and replaced by a new one, entailing an increase in antibiotic consumption, together with a health costs of about 50,000-90,000 per infection episode. Taking both problems in account, the search of new antimicrobial agents that will be effective against the bacteria in their two ways of life, planktonic and biofilm stage, is a priority need in the clinical practice. For this reason, the overall objective of NOMORFILM project is to search for antibiofilm compounds isolated from microalgae that will be useful in the treatment of this kind of infections and could be incorporated in the manufacturing of medical prosthetic devices. For this purpose, 4,000 microalgae species will be deeply screened specifically for new antibacterial and antibiofilm molecules. Structural elucidation of bioactive compounds from these extracts will assure that only new chemical entities, therefore with anticipated new mechanisms of action, will arise to further project stages, those including toxicity tests and animal models. This project also addresses the biosynthesis of the targeted bioactive compounds in sustainable microalgae co-cultures, diminishing cultivation costs by mimicking natural aquatic ecosystems. Most industrially interesting antibiofilm molecules will be incorporated into nanoparticles in order to develop manufacturing methodologies able to incorporate these compounds into real prosthetic devices matrixes. Marketing of results are assured by the presence of diverse SMEs along the manufacture and distribution of prosthetic devices, and the corresponding consortium agreements with respect to IPRs

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2007.6.3 | Award Amount: 13.61M | Year: 2008

The GENESIS Project has the objective of providing Environment management and Health actors with an innovative solution based on advanced ICT. Relying on interoperability standards and harmonization process, GENESIS helps to constitute complex information networks, by combining benefits of various information systems with a collaborative systems approach. The proposed generic solution allows easy deployment and customization to thematic needs on a wide range of applications, at regional, national or Europe levels for various thematic fields. The main benefits of GENESIS solution are two-fold :-to improve and facilitate actors daily practices in relation with the management of environmental data; -to perform an essential step in the deployment of the Single Information Space for the environment in Europe. The GENESIS solution will be validated through dedicated scenarios addressing thematic fields of Air Quality, Water Quality and their impact on Health. For the final benefits and information of European citizens, the needs of Environment and Health stakeholders are covered through fundamental services like : -environment monitoring,\n-multi-criteria finding of the information; -visualization and combination of static or near-real-time information; -fusion of various sources of environmental data; -correlation between environmental with health data; -support of decision making processes; -support of the risk management and response to crisis; -near-real-time information of citizens. The GENESIS generic solution is open and sustainable as based on de facto and emerging standards (OGC, OASIS, INSPIRE,...). Moreover, the GENESIS project development integrates current state of the art and innovative researches of major EC or ESA projects. GENERIS project represents an important step in operational environmental management in Europe thus paving the way to an effective wide deployment of the solution as part of the future Single European Information Space for Environment.

Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.54M | Year: 2013

SPRITE is a multi-disciplinary European training network which brings together Europes premier research institutes in technology and applications of ion beams. Those involved are already actively collaborating, for example in the recently very favourably reviewed EC Infrastructure project SPIRIT. SPRITE addresses the urgent European need - identified in a recent Foresight Review - to train the next generation of researchers in this multi- and supra- disciplinary emerging field. Through its Internship Mobility Partnerships (IMPs) SPRITE offers an innovative training package, providing the researchers with the opportunity to gain real world experience and business facing skills in the private and public sectors. In addition, ELVEs (European Laboratory Visit Exchanges) are an integral part of the training program. In combination with the IMPs, every ER and ESR will thus spend up to 30% of its time outside its host laboratory, part of this time in another EC country. Collaboration with the IAEA opens up a further dimension to SPRITE, enabling the researchers to put their research into a global context and to interact with scientists from all over the world. Despite the numerous participants SPRITE is able to offer a personalized training program. For this purpose the Action Planner, a web-based training needs analysis tool, developed at the University of Surrey will be used. This maps on to the Researcher Development Framework, currently being trialled by the European Science Foundation. Action Planner allows the training for each researcher to be tailored to their individual needs and aspirations. In addition to individualized training, SPRITE organizes network wide training events, encompassing amongst others technical training and business facing skills. In this way SPRITE researchers will leave not only as a brilliant and experienced researcher but also as a skilled manager, able to lead their own group.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: GC-ICT-2011.6.8 | Award Amount: 5.75M | Year: 2012

Smart Power ICs are extensively used in automotive embedded systems due to their unique capabilities to merge low power and high voltage devices on the same chip, at competitive cost. In such devices, induced electrical coupling noise due to switching of the power stages, when integrating such high voltage (HV) devices with low voltage (LV) functions, is a big issue. During switching, parasitic voltages and currents, consisting of electrons and holes, lead to a local shift of the substrate potential that can reach hundreds of millivolts. This electrical coupling noise can severely disturb low voltage circuits. Such parasitic signals are known to represent the major cause of failure and costly circuit redesign in power integrated circuits. Furthermore, parasitic carrier injections are considerably increased under high temperature operation such as those encountered in automotive applications where this problem is even more severe since these dedicated ICs need to be highly reliable and stable with time. Most solutions are layout dependent and are thus difficult to optimize using available electrical simulator software. The lack for a model strategy that would enable to simulate accurately the injection of minority carriers in the substrate as part of the HV model, as well as its propagation in the substrate, is one of the main reasons for this critical situation. This lack for a design methodology prohibits an efficient design strategy and fails at giving clear predictions of perturbations in high voltage integrated circuits. This picture motivates this project proposal where all these aspects are addressed to create a link between circuit design, modeling and implementation in innovative computer aided design tools. This concerns smart power ICs dedicated to automotive applications requiring co-integration of high voltage power stages with low voltage analog/digital blocks on the same chip, still being reliable\nwhen operating at high temperature.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2007.1.1 | Award Amount: 23.39M | Year: 2008

Todays network architectures are stifling innovation, restricting it mostly to the application level while the need for structural change is increasingly evident. The absence of adequate facilities to design, optimize and interoperate new networks currently forces a convergence to an architecture that is suboptimal for many applications and that cannot support innovations within itself, the Internet.\n4WARD overcomes this impasse through a set of radical architectural approaches built on our strong mobile and wireless background.. We improve our ability to design inter-operable and complementary families of network architectures. We enable the co-existence of multiple networks on common platforms through carrier-grade virtualization for networking resources. We enhance the utility of networks by making them self-managing. We increase their robustness and efficiency by leveraging diversity. Finally we improve application support by a new information-centric paradigm in place of the old host-centric approach. These solutions will embrace the full range of technologies, from fibre backbones to wireless and sensor networks.\nThe 4WARD results will allow new markets to appear, redefining business roles and creating new economic models. We will establish the Future Internet Forum as a leading standards body, enabling these new markets and opening them for old and new players alike, increasing opportunities for competition and cooperation and creating new products and services.\nThese goals can only be achieved by gathering a strong, industry-led consortium of the leading operators, vendors, SME, and research organisations, with the determination, skills, and critical mass to create cross-industry consensus and to drive standardisation. The project is designed for multiple phases; the first one will establish the core concepts and technologies and last for two years. The planned effort of about 2200 person months corresponds to the strategic importance of this endeavour.

Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: INFRA-2010-1.2.3 | Award Amount: 6.26M | Year: 2010

Biodiversity science brings information science and technologies to bear on the data and information generated by the study of organisms, their genes, and their interactions. ViBRANT will help focus the collective output of biodiversity science, making it more transparent, accountable, and accessible. Mobilising these data will address global environmental challenges, contribute to sustainable development, and promote the conservation of biological diversity. Through a platform of web based informatics tools and services we have built a successful data-publishing framework (Scratchpads) that allows distributed groups of scientists to create their own virtual research communities supporting biodiversity science. The infrastructure is highly user-oriented, focusing on the needs of research networks through a flexible and scalable system architecture, offering adaptable user interfaces for the development of various services. In just 28 months the Scratchpads have been adopted by over 120 communities in more than 60 countries, embracing over 1,500 users. ViBRANT will distribute the management, hardware infrastructure and software development of this system and connect with the broader landscape of biodiversity initiatives including PESI, Biodiversity Heritage Library (Europe), GBIF and EoL. The system will also inform the design of the LifeWatch Service Centre and is aligned with the ELIXIR and EMBRC objectives, all part of the ESFRI roadmap. ViBRANT will extend the userbase, reaching out to new multidisciplinary communities including citizen scientists by offering an enhanced suite of services and functionality.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.9.9 | Award Amount: 11.78M | Year: 2013

The overarching goal of our project is to develop systems based on direct and deterministic interactions between individual quantum entities, which by involving large-scale entanglement can outperform classical systems in a series of relevant applications.\nWe plan to achieve that by improving technologies from atomic, molecular and optical physics as well as from solid-state physics, and by developing new ones, including combinations across those different domains. We will explore a wide range of experimental platforms as enabling technologies: from cold collisions or Rydberg blockade in neutral atoms to electrostatic or spin interactions in charged systems like trapped ions and quantum dots; from photon-phonon interactions in nano-mechanics to photon-photon interactions in cavity quantum electrodynamics and to spin-photon interactions in diamond color centers.\nWe will work on two deeply interconnected lines to build experimentally working implementations of quantum simulators and of quantum interfaces. This will enable us to conceive and realize applications exploiting those devices for simulating important problems in other fields of physics, as well as for carrying out protocols outperforming classical communication and measurement systems.

News Article | October 28, 2016

MENLO PARK, CA--(Marketwired - October 24, 2016) - ONOS Project, the rapidly growing open source community advancing the software-defined networking (SDN) OS for service providers with high availability, scale and performance and the right abstractions to create apps and services, today announced BII, Canonical, NCTU and UPMC have joined as collaborators. To build on the continued project momentum, more than 215 ONOS® developers focused on coding and testing will converge in Paris from November 2-4 for the project's first large-scale developer summit, ONOS Build 2016. "ONOS Build 2016 will offer the unique opportunity for ONOS users and contributors across the globe to meet, align, plan and hack together in-person," said Bill Snow, VP of engineering for ON.Lab. "Open to members and non-members alike, attendees will have the chance to talk directly with the ONOS core architects and Technical Steering Team, collaborate on ideas that will directly impact the future of ONOS, and promote their work among the community." The ONOS Build 2016 agenda includes a mix of sharing the ONOS roadmap, social activities for the community to bond, and hacking activities to help deliver specific features in the pipeline. The event will feature keynotes and industry panelists from ONOS community partners and collaborators Ciena, Create-Net, DT, GARR, Huawei, NOKIA Bell Labs, NTT Communications, ON.Lab, Radisys and UPMC. Topics for discussion will include basics of the ONOS architecture, northbound and southbound protocols, deployments, application development, performance and testing, community planning and the Ambassador program. Click here to learn more about the confirmed speakers. A separate Community Showcase track will be devoted to members and ONOS Brigade teams presenting updates on interesting new features developed by and for the ONOS community through open source collaboration. For example, the Dynamic Configuration Brigade has focused on building a vendor-agnostic driver into ONOS that allows automatic discovery and activation of NETCONF-enabled devices and services into the network as long as they expose a Yang Model. Click here to read more about the ONOS Brigades, and here to view the complete ONOS Build 2016 agenda. To obtain an ONOS Build ticket, complete the online registration form. ONOS Build 2016 is free for students and ONOS contributors. General admission costs $400 USD. ONOS is grateful for its generous sponsors who are helping organize the event. These include Platinum sponsors Ciena, Fujitsu, and Huawei, Gold sponsors Kisti and Radisys, and Silver sponsors ADARA Networks and Gandi. If interested in sponsoring ONOS Build 2016 or future Build events, please contact More about the new ONOS collaborators: BII: BII Group Holdings Ltd. centered on the core of technical research and development, seated on the basis of testing service, and navigated by internationalization and marketization, is a global open platform for internet infrastructure technologies with a focus on IPv6, Domain Name System (DNS), SDN and Internet of Things (IoT). Canonical: Canonical is the company behind Ubuntu, the leading OS for container, cloud, scale-out and hyperscale computing. 65% of large-scale OpenStack deployments are on Ubuntu, using both KVM and the pure-container LXD hypervisor for the world's fastest private clouds. Canonical provides enterprise support and services for commercial users of Ubuntu. NCTU: National Chiao Tung University (NCTU) is a prestigious university known for its special strengths in the areas of computer science and electronics engineering. Its highly-reputable computer science department, which is the largest one in Taiwan, will participate in the ONOS Project with a focus on SDN-IP. UPMC: The University Pierre and Marie Curie LIP6 computer science research laboratory is dedicated to application modeling and testing, as well as implementation and validation through academic and industry partnerships. Currently, LIP6 is strategizing data consistency for distributed network control-plane systems, and enhancing SDN southbound interfaces. Redefining network economics, ONOS provides the only SDN control plane that can support both disruptive and incremental SDN for service providers and enterprises seeking to virtualize and optimize their networks to keep agile pace with the explosion of mobile devices, video and big data applications. The rapidly growing and diverse ONOS community comprises a core engineering team at ON.Lab, along with developers from service providers, vendors and Research and Educational Networks spanning across industries. Whether an individual or an organization, as an open source project all are encouraged to get involved with the growing ONOS community and help contribute to the project today. ONOS® is the open source SDN networking operating system for Service Provider networks architected for high performance, scale and availability. The ONOS ecosystem comprises ON.Lab, organizations that are funding and contributing to the ONOS initiative, and individual contributors. These organizations include AT&T, China Unicom, Comcast, Google, NTT Communications Corp., SK Telecom Co. Ltd., Verizon, Ciena Corporation, Cisco Systems, Inc., Ericsson, Fujitsu Ltd., Huawei Technologies Co. Ltd., Intel Corporation, NEC Corporation, Nokia, Radisys and Samsung. See the full list of members, including ONOS' collaborators, and learn how you can get involved with ONOS at ONOS is an independently funded software project hosted by The Linux Foundation, the nonprofit advancing professional open source management for mass collaboration to fuel innovation across industries and ecosystems.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.1.7 | Award Amount: 2.41M | Year: 2013

Forging Online Education through FIRE (FORGE) is a project proposal bringing the FIRE and eLearning worlds together. FORGE will align FIRE with the ongoing education revolution for mutual benefit. In particular, this project is concerned with specifying development methodologies and best practices for offering FIRE experimentation facilities to learners and to the learning community in general, related both to communications and IT but also to other disciplines including the sciences and social sciences, leading to a strong connection between the learning community and existing FIRE platforms and supporting tools. The learning community will benefit from the use of the very high performance facilities. FIRE will benefit through the addition of an ever-growing set of FIRE-specific learning materials for an increasing number of FIRE-based students, leading to increased awareness and use.\nWithin the FORGE project we will:\n Study and develop new processes and approaches to online learning based on the integration of FIRE facilities and eLearning technologies.\n Inject into the higher education learning sphere the FIRE portfolio of facilities and tools.\n Introduce the learning community to the concepts of Experimentally Driven Research.\n Increase the overall accessibility and usability of FIRE facilities through the layering of how-to-use resources over the FIRE platforms.\nThe FORGE project believes that it is the right time for students, especially those at higher education institutes, to become familiar with FIREs portfolio. Most FIRE platforms and tools are already sufficiently mature to be used by end-users and thus can be introduced seamlessly to current student curricula. Moreover, by targeting students we are aiming at the next-generation future-internet facilities users who having learnt through FIRE facilities will be enthusiastic future FIRE users. By investing in students, FORGE is creating a path for FIREs long-term sustainability.

Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: INFRA-2010-1.2.1 | Award Amount: 70.14M | Year: 2010

Scientific research is no longer conducted within national boundaries and is becoming increasing dependent on the large-scale analysis of data, generated from instruments or computer simulations housed in trans-national facilities, by using e Infrastructure (distributed computing and storage resources linked by high-performance networks).\nThe 48 month EGI-InSPIRE project will continue the transition to a sustainable pan-European e-Infrastructure started in EGEE-III. It will sustain support for Grids of high-performance and high-throughput computing resources, while seeking to integrate new Distributed Computing Infrastructures (DCIs), i.e. Clouds, SuperComputing, Desktop Grids, etc., as they are required by the European user community. It will establish a central coordinating organisation,, and support the staff throughout Europe necessary to integrate and interoperate individual national grid infrastructures. will provide a coordinating hub for European DCIs, working to bring existing technologies into a single integrated persistent production infrastructure for researchers within the European Research Area.\nEGI-InSPIRE will collect requirements and provide user-support for the current and new (e.g. ESFRI) users. Support will also be given for the current heavy users as they move their critical services and tools from a central support model to ones driven by their own individual communities. The project will define, verify and integrate within the Unified Middleware Distribution, the middleware from external providers needed to access the e-Infrastructure. The operational tools will be extended by the project to support a national operational deployment model, include new DCI technologies in the production infrastructure and the associated accounting information to help define EGIs future revenue model.

Agency: Cordis | Branch: FP7 | Program: CP-IP-SICA | Phase: OCEAN.2011-3 | Award Amount: 16.99M | Year: 2012

The overall scientific objectives of PERSEUS are to identify the interacting patterns of natural and human-derived pressures on the Mediterranean and Black Seas, assess their impact on marine ecosystems and, using the objectives and principles of the Marine Strategy Framework Directive as a vehicle, to design an effective and innovative research governance framework based on sound scientific knowledge. Well-coordinated scientific research and socio-economic analysis will be applied at a wide-ranging scale, from basin to coastal. The new knowledge will advance our understanding on the selection and application of the appropriate descriptors and indicators of the MSFD. New tools will be developed in order to evaluate the current environmental status, by way of combining monitoring and modelling capabilities and existing observational systems will be upgraded and extended. Moreover, PERSEUS will develop a concept of an innovative, small research vessel, aiming to serve as a scientific survey tool, in very shallow areas, where the currently available research vessels are inadequate. In view of reaching Good Environmental Status (GES), a scenario-based framework of adaptive policies and management schemes will be developed. Scenarios of a suitable time frame and spatial scope will be used to explore interactions between projected anthropogenic and natural pressures. A feasible and realistic adaptation policy framework will be defined and ranked in relation to vulnerable marine sectors/groups/regions in order to design management schemes for marine governance. Finally, the project will promote the principles and objectives outlined in the MSFD across the SES. Leading research Institutes and SMEs from EU Member States, Associated States, Associated Candidate countries, non-EU Mediterranean and Black Sea countries, will join forces in a coordinated manner, in order to address common environmental pressures, and ultimately, take action in the challenge of achieving GES.

Parkinsons disease (PD) is a major, chronic, non-communicable disease and the 2nd most frequent neurodegenerative disorder worldwide. Excess iron is primarily detected in the substantia nigra pars compacta, where dopaminergic neurons are exposed to high levels of oxidative stress produced by mitochondrial disorders and dopamine metabolism. Our previous preclinical, translational and pilot clinical studies demonstrated that novel iron chelation therapy with the prototypic drug deferiprone (DFP) (i) induces neuroprotection in cell models of PD via a powerful antioxidant effect, (ii) reduces regional siderosis of the brain, (iii) reduces motor handicap via inhibition of catechol-o-methyl transferase, and (iv) slows the progression of motor handicap in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model and in early PD patients. This project now seeks to demonstrate that conservative iron chelation therapy with moderate-dose DFP (30 mg/kg/day) slows the progression of handicap in de novo PD patients while not affecting systemic parameters. The 9-month, parallel-group, randomized, placebo-controlled, multicentre trial will be followed by a 1-month wash-out period. The primary efficacy criterion will be the change in motor and non-motor handicap scores on the Total Movement Disorders Society Unified Parkinsons Disease Rating Scale to identify disease-modifying and symptomatic effects. The secondary efficacy criterion will be the change in score between baseline and 40 weeks (i.e. probing the disease-modifying effect only). Potential surrogate radiological and biological biomarkers, health economics and societal impacts will be assessed. 17 national, European and international research and innovation activities will be linked with the project. The study results should prompt academic and industrial research on iron chelation as a disease-modifying treatment in neurodegenerative diseases.

Brunel N.,University of Chicago | Hakim V.,University Pierre and Marie Curie | Richardson M.J.E.,University of Warwick
Current Opinion in Neurobiology | Year: 2014

At the single neuron level, information processing involves the transformation of input spike trains into an appropriate output spike train. Building upon the classical view of a neuron as a threshold device, models have been developed in recent years that take into account the diverse electrophysiological make-up of neurons and accurately describe their input-output relations. Here, we review these recent advances and survey the computational roles that they have uncovered for various electrophysiological properties, for dendritic arbor anatomy as well as for short-term synaptic plasticity. © 2014 Elsevier Ltd.

Westerhold T.,University of Bremen | Rohl U.,University of Bremen | Laskar J.,University Pierre and Marie Curie
Geochemistry, Geophysics, Geosystems | Year: 2012

Timing is crucial to understanding the causes and consequences of events in Earth history. The calibration of geological time relies heavily on the accuracy of radioisotopic and astronomical dating. Uncertainties in the computations of Earth's orbital parameters and in radioisotopic dating have hampered the construction of a reliable astronomically calibrated time scale beyond 40 Ma. Attempts to construct a robust astronomically tuned time scale for the early Paleogene by integrating radioisotopic and astronomical dating are only partially consistent. Here, using the new La2010 and La2011 orbital solutions, we present the first accurate astronomically calibrated time scale for the early Paleogene (47-65 Ma) uniquely based on astronomical tuning and thus independent of the radioisotopic determination of the Fish Canyon standard. Comparison with geological data confirms the stability of the new La2011 solution back to ∼54 Ma. Subsequent anchoring of floating chronologies to the La2011 solution using the very long eccentricity nodes provides an absolute age of 55.530 0.05 Ma for the onset of the Paleocene/Eocene Thermal Maximum (PETM), 54.850 0.05 Ma for the early Eocene ash -17, and 65.250 0.06 Ma for the K/Pg boundary. The new astrochronology presented here indicates that the intercalibration and synchronization of U/Pb and 40Ar/ 39Ar radioisotopic geochronology is much more challenging than previously thought. ©2012. American Geophysical Union. All Rights Reserved. 1 of 19.

Ducloue B.,University Paris - Sud | Szymanowski L.,National Center for Nuclear Research | Wallon S.,University Paris - Sud | Wallon S.,University Pierre and Marie Curie
Physical Review Letters | Year: 2014

The study of the production of two forward jets with a large interval of rapidity at hadron colliders was proposed by Mueller and Navelet as a possible test of the high energy dynamics of QCD. We analyze this process within a complete next-to-leading logarithm framework, supplemented by the use of the Brodsky-Lepage-Mackenzie procedure extended to the perturbative Regge dynamics, to find the optimal renormalization scale. This leads to a very good description of the recent CMS data at LHC for the azimuthal correlations of the jets. © 2014 American Physical Society.

Callan-Jones A.C.,CNRS Charles Coulomb Laboratory | Voituriez R.,University Pierre and Marie Curie
New Journal of Physics | Year: 2013

We develop a model of amoeboid cell motility based on active gel theory. Modeling the motile apparatus of a eukaryotic cell as a confined layer of finite length of poroelastic active gel permeated by a solvent, we first show that, due to active stress and gel turnover, an initially static and homogeneous layer can undergo a contractile-type instability to a polarized moving state in which the rear is enriched in gel polymer. This agrees qualitatively with motile cells containing an actomyosin-rich uropod at their rear. We find that the gel layer settles into a steadily moving, inhomogeneous state at long times, sustained by a balance between contractility and filament turnover. In addition, our model predicts an optimal value of the gel-substrate adhesion leading to maximum layer speed, in agreement with cell motility assays. The model may be relevant to motility of cells translocating in complex, confining environments that can be mimicked experimentally by cell migration through microchannels. © IOP Publishing and Deutsche Physikalische Gesellschaft.

Pawlus S.,University of Silesia | Klotz S.,University Pierre and Marie Curie | Paluch M.,University of Silesia
Physical Review Letters | Year: 2013

High pressure viscosity and dielectric measurements were carried out on two monohydroxy alcohols, 2-ethyl-1-hexanol and 5-methyl-2-hexanol, at room temperature. Analysis of the dielectric relaxation times versus viscosity revealed the breakdown of the Einstein-Debye relation above some characteristic pressure. The failure of the Einstein-Debye relation is a manifestation of pressure induced changes of supramolecular hydrogen bonded structures which occur in these liquids. © 2013 American Physical Society.

Yang Z.,University Pierre and Marie Curie | Lisiecki I.,University Pierre and Marie Curie | Walls M.,University Paris - Sud | Pileni M.-P.,University Pierre and Marie Curie
ACS Nano | Year: 2013

Here it is demonstrated that the diffusion process of oxygen in Co nanoparticles is controlled by their 2D ordering and crystallinity. The crystallinity of isolated Co nanoparticles deposited on a substrate does not play any role in the oxide formation. When they are self-assembled in 2D superlattices, the oxidation process is slowed and produces either core/shell (Co/CoO) nanoparticles or hollow CoO nanocrystals. This is attributed to the decrease in the oxygen diffusion rate when the nanoparticles are interdigitated. Initially, polycrystalline nanoparticles form core/shell (Co/CoO) structures, while for single-domain hexagonal close-packed Co nanocrystals, the outward diffusion of Co ions is favored over the inward diffusion of oxygen, producing hollow CoO single-domain nanocrystals. © 2013 American Chemical Society.

Messina R.,University Pierre and Marie Curie | Antezza M.,CNRS Charles Coulomb Laboratory
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2011

We study the radiative heat transfer and the Casimir-Lifshitz force occurring between two bodies in a system out of thermal equilibrium. We consider bodies of arbitrary shape and dielectric properties, held at two different temperatures and immersed in environmental radiation at a third different temperature. We derive explicit closed-form analytic expressions for the correlations of the electromagnetic field and for the heat transfer and Casimir-Lifshitz force in terms of the bodies' scattering matrices. We then consider some particular cases which we investigate in detail: the atom-surface and the slab-slab configurations. © 2011 American Physical Society.

De Medici L.,University Pierre and Marie Curie | De Medici L.,University Paris - Sud | De Medici L.,European Synchrotron Radiation Facility | Giovannetti G.,International School for Advanced Studies | Capone M.,International School for Advanced Studies
Physical Review Letters | Year: 2014

We show that electron- and hole-doped BaFe2As2 are strongly influenced by a Mott insulator that would be realized for half-filled conduction bands. Experiments show that weakly and strongly correlated conduction electrons coexist in much of the phase diagram, a differentiation which increases with hole doping. This selective Mottness is caused by the Hund's coupling effect of decoupling the charge excitations in different orbitals. Each orbital then behaves as a single-band doped Mott insulator, where the correlation degree mainly depends on how doped is each orbital from half filling. Our scenario reconciles contrasting evidences on the electronic correlation strength, implies a strong asymmetry between hole and electron doping, and establishes a deep connection with the cuprates. © 2014 American Physical Society.

Katz B.F.G.,University Paris - Sud | Noisternig M.,University Pierre and Marie Curie
Journal of the Acoustical Society of America | Year: 2014

The Interaural Time Delay (ITD) is an important binaural cue for sound source localization. Calculations of ITD values are obtained either from measured time domain Head-Related Impulse Responses (HRIRs) or from their frequency transform Head-Related Transfer Functions (HRTFs). Numerous methods exist in current literature, based on a variety of definitions and assumptions of the nature of the ITD as an acoustic cue. This work presents a thorough comparative study of the degree of variability between some of the most common methods for calculating the ITD from measured data. Thirty-two different calculations or variations are compared for positions on the horizontal plane for the HRTF measured on both a KEMAR mannequin and a rigid sphere. Specifically, the spatial variations of the methods are investigated. Included is a discussion of the primary potential causes of these differences, such as the existence of multiple peaks in the HRIR of the contra-lateral ear for azimuths near the inter-aural axis due to multipath propagation and head/pinnae shadowing. © 2014 Acoustical Society of America.

Blanchet L.,University Pierre and Marie Curie | Heisenberg L.,KTH Royal Institute of Technology | Heisenberg L.,The Oskar Klein Center
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2015

In this work we investigate the existence of relativistic models for dark matter in the context of bimetric gravity, used here to reproduce the modified Newtonian dynamics (MOND) at galactic scales. For this purpose we consider two different species of dark matter particles that separately couple to the two metrics of bigravity. These two sectors are linked together via an internal U(1) vector field, and some effective composite metric built out of the two metrics. Among possible models only certain classes of kinetic and interaction terms are allowed without invoking ghost degrees of freedom. Along these lines we explore the number of allowed kinetic terms in the theory and point out the presence of ghosts in a previous model. Finally, we propose a promising class of ghost-free candidate theories that could provide the MOND phenomenology at galactic scales while reproducing the standard cold dark matter model at cosmological scales. © 2015 American Physical Society.

Abecassis B.,University Paris - Sud | Tessier M.D.,University Pierre and Marie Curie | Davidson P.,University Paris - Sud | Dubertret B.,University Pierre and Marie Curie
Nano Letters | Year: 2014

We report on the self-assembly of colloidal CdSe nanoplatelets into micrometers long anisotropic needle-like superparticles (SPs), which are formed in solution upon addition of an antisolvent to a stable colloidal dispersion. Optical fluorescence microscopy, transmission electron microscopy, and small-angle X-ray scattering provide detailed structural characterization and show that each particle is composed of 106 nanoplatelets organized in highly aligned columns. Within the SPs, the nanoplatelets are stacked on each other to maximize the contact surface between the ligands. When deposited on a substrate, the planes of the platelets are oriented perpendicularly to its surface and the SPs exhibit polarized emission properties. © 2013 American Chemical Society.

Babichev E.,University Paris - Sud | Babichev E.,University Pierre and Marie Curie | Esposito-Farese G.,University Pierre and Marie Curie
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

We study spherically symmetric solutions of the cubic covariant Galileon model in curved spacetime in the presence of a matter source, in the test scalar field approximation. We show that a cosmological time evolution of the Galileon field gives rise to an induced matter-scalar coupling, due to the Galileon-graviton kinetic braiding, therefore the solution for the Galileon field is nontrivial even if the bare matter-scalar coupling constant is set to zero. The local solution crucially depends on the asymptotic boundary conditions, and in particular, Minkowski and de Sitter asymptotics correspond to different branches of the solution. We study the stability of these solutions, namely, the well posedness of the Cauchy problem and the positivity of energy for scalar and tensor perturbations, by diagonalizing the kinetic terms of the spin-2 and spin-0 degrees of freedom. In addition, we find that in the presence of a cosmological time evolution of the Galileon field, its kinetic mixing with the graviton leads to a friction force resulting in efficient damping of scalar perturbations within matter. © 2013 American Physical Society.

Naim V.,University Paris - Sud | Naim V.,Institute Gustave Roussy | Wilhelm T.,University Pierre and Marie Curie | Debatisse M.,University Pierre and Marie Curie | And 2 more authors.
Nature Cell Biology | Year: 2013

Chromosomal instability (CIN) is a hallmark of tumour initiation and progression. Some genomic regions are particularly unstable under replication stress, notably common fragile sites (CFSs) whose rearrangements in tumour cells contribute to cancer development. Recent work has shown that the Fanconi anaemia (FANC) pathway plays a role in preventing defective chromosome segregation and CIN under conditions of replication stress. Strikingly, FANCD2 is recruited to regions hosting CFSs on metaphase chromosomes. To decipher the mechanisms protecting CFSs in G2/M, we searched for proteins that co-localize with FANCD2 on mitotic chromosomes, and identified XPF-ERCC1 and MUS81-EME1, two structure-specific endonucleases. We show that depletion of either ERCC1 or MUS81-EME1 affects accurate processing of replication intermediates or under-replicated DNA that persist at CFSs until mitosis. Depletion of these endonucleases also leads to an increase in the frequency of chromosome bridges during anaphase that, in turn, favours accumulation of DNA damage in the following G1 phase. © 2013 Macmillan Publishers Limited. All rights reserved.

Muller S.,University Pierre and Marie Curie | Rodriguez R.,CNRS Institute of Chemistry
Expert Review of Clinical Pharmacology | Year: 2014

G-quadruplexes are non-Watson-Crick four-stranded nucleic acid structures. Recent evidence points toward their existence in vivo and their implication in various biological processes. Over the past two decades, small molecules have been developed to specifically and selectively target these structures in order to dissect mechanisms they have been linked to. This has led to the development of potential therapeutic agents, particularly for anti-carcinogenic activity. Here, we first present how major biological roles of G-quadruplexes have been uncovered by the use of specifically designed small molecule probes. We use this to highlight how fundamental research has contributed to identifying biological functions of G-quadruplexes and their potential as therapeutic targets. We then discuss the development of G-quadruplex interacting small molecules as potential drug candidates. © 2014 Informa UK Ltd.

Gorisse D.,Yakaz Laboratory | Cord M.,University Pierre and Marie Curie | Precioso F.,CNRS Informatics, Signals & Systems Lab in Sophia Antipolis
IEEE Transactions on Pattern Analysis and Machine Intelligence | Year: 2012

In the past 10 years, new powerful algorithms based on efficient data structures have been proposed to solve the problem of Nearest Neighbors search (or Approximate Nearest Neighbors search). If the Euclidean Locality Sensitive Hashing algorithm, which provides approximate nearest neighbors in a euclidean space with sublinear complexity, is probably the most popular, the euclidean metric does not always provide as accurate and as relevant results when considering similarity measure as the Earth-Mover Distance and distances. In this paper, we present a new LSH scheme adapted to distance for approximate nearest neighbors search in high-dimensional spaces. We define the specific hashing functions, we prove their local-sensitivity, and compare, through experiments, our method with the Euclidean Locality Sensitive Hashing algorithm in the context of image retrieval on real image databases. The results prove the relevance of such a new LSH scheme either providing far better accuracy in the context of image retrieval than euclidean scheme for an equivalent speed, or providing an equivalent accuracy but with a high gain in terms of processing speed. © 2012 IEEE.

Kwon Y.-O.,Woods Hole Oceanographic Institution | Frankignoul C.,University Pierre and Marie Curie
Climate Dynamics | Year: 2012

The Atlantic meridional overturning circulation (AMOC) in the last 250 years of the 700-year-long present-day control integration of the Community Climate System Model version 3 with T85 atmospheric resolution exhibits a red noise-like irregular multi-decadal variability with a persistence longer than 10 years, which markedly contrasts with the preceding ~300 years of very regular and stronger AMOC variability with ~20 year periodicity. The red noise-like multi-decadal AMOC variability is primarily forced by the surface fluxes associated with stochastic changes in the North Atlantic Oscillation (NAO) that intensify and shift northward the deep convection in the Labrador Sea. However, the persistence of the AMOC and the associated oceanic anomalies that are directly forced by the NAO forcing does not exceed about 5 years. The additional persistence originates from anomalous horizontal advection and vertical mixing, which generate density anomalies on the continental shelf along the eastern boundary of the subpolar gyre. These anomalies are subsequently advected by the mean boundary current into the northern part of the Labrador Sea convection region, reinforcing the density changes directly forced by the NAO. As no evidence was found of a clear two-way coupling with the atmosphere, the multi-decadal AMOC variability in the last 250 years of the integration is an ocean-only response to stochastic NAO forcing with a delayed positive feedback caused by the changes in the horizontal ocean circulation. © 2011 Springer-Verlag.

Bouraoui F.,European Commission - Joint Research Center Ispra | Grizzetti B.,University Pierre and Marie Curie
Science of the Total Environment | Year: 2014

Agriculture is responsible for large scale water quality degradation and is estimated to contribute around 55% of the nitrogen entering the European Seas. The key policy instrument for protecting inland, transitional and coastal water resources is the Water Framework Directive (WFD). Reducing nutrient losses from agriculture is crucial to the successful implementation of the WFD. There are several mitigation measures that can be implemented to reduce nitrogen losses from agricultural areas to surface and ground waters. For the selection of appropriate measures, models are useful for quantifying the expected impacts and the associated costs. In this article we review some of the models used in Europe to assess the effectiveness of nitrogen mitigation measures, ranging from fertilizer management to the construction of riparian areas and wetlands. We highlight how the complexity of models is correlated with the type of scenarios that can be tested, with conceptual models mostly used to evaluate the impact of reduced fertilizer application, and the physically-based models used to evaluate the timing and location of mitigation options and the response times. We underline the importance of considering the lag time between the implementation of measures and effects on water quality. Models can be effective tools for targeting mitigation measures (identifying critical areas and timing), for evaluating their cost effectiveness, for taking into consideration pollution swapping and considering potential trade-offs in contrasting environmental objectives. Models are also useful for involving stakeholders during the development of catchments mitigation plans, increasing their acceptability. © 2013 Elsevier B.V.

Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-ITN-2008 | Award Amount: 3.75M | Year: 2009

This ITN project will train young investigators to enable them make significant advances in the field of in situ sensor technology. It will bring together 15 research groups and 2 industrial partners from across the European Union. The ITN will provide training for 16 PhD students, early stage researchers (ESRs) and 1 Postdoctoral student, experienced researcher (ER). The programme will combine the strengths of the leading marine and engineering research groups in the EU, and through a structured and extensive programme of collaboration and student exchange, will provide a powerful, cohesive marine sensor development programme. Fundamentally, the outcome of this ITN will be to equip Europe with a network of young scientist/engineers, who will share a common technical culture and approach, and who will ultimately enable the monitoring of our fragile yet rapidly changing marine environment.

Essilor, University Pierre and Marie Curie | Date: 2012-12-06

An optical device including: an optical substrate provided with selective optical filtering element configured to selectively inhibit transmission, through the optical substrate of at least one selected range of wavelengths of incident light in the visible light spectrum at an inhibition rate of at least 5%, the selective optical filtering element being further configured to transmit at least 8% of incident light of the visible spectrum outside the at least one selected range of wavelengths; wherein the at least one selected range of wavelengths has a bandwidth in a range of from 10 nm to 70 nm, preferably 10 nm to 60 nm centered on a wavelength within a range of between 430 nm and 465 nm.

Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 5.72M | Year: 2012

Over the past year a new research field has emerged: cavity Optomechanics which brings the quantum regime of mechanical oscillators in reach and may allow to explore new fundamental measurements concepts, may lead to novel transducers and test quantum mechanics on a macroscopic scale. In this research field, which utilizes mechanical oscillators coupled to laser fields, Europe has played a pioneering role. The distinguishing feature of this ITN training network is that the partners are active in this research field (cavity Optomechanics), which facilitates and indeed leverages the collaborative effort and will make this ITN highly effective. Cavity optomechanics is moreover a field which is highly faceted in terms of the required and offered training skills that spans quantum optics, nanofabrication, finite element simulation and cryogenic expertise and techniques as well as quantum theory. To effectively train new students it is therefore pivotal to train students in all relevant skills and techniques and theory. The realization that a single group is much less efficient than a consortium is the major driving force behind the ITN network. It will provide a streamlined, high quality-training program that offers a remarkably diverse set of skills. This training program will be of immediate benefit to the partners that will thereby obtain a superior training of their PhD students, which therefore provides a build-in mechanism that will ensure the effective realization of the proposed ITN training program and it success. The existence of such a training program, which will be opened to international groups, will contribute to the visibility of the EU cavity optomechanics community in an international setting.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.5.5 | Award Amount: 2.86M | Year: 2011

The number of young people not in employment, education or training (NEET) is increasing across Europe. Current research reveals that NEETs often lack self-confidence and the essential social skills needed to seek and secure employment. Youth inclusion associations across Europe provide social coaching programmes, in order to help young people acquire and improve their social competencies. However, it is an expensive and time-consuming approach that relies on the availability of trained practitioners as well as the willingness of the young people to engage in exploring their social strengths and weakness in front of their peers and practitioners.\nDigital technologies such as serious-games offer the advantage of repeatable experience that can be modulated to suit the individual needs of the young people. Additionally, such technologies are intrinsically motivating to the young and carry the potential of removing the many barriers that real-life situations may pose, in particular the stress associated with engaging in unfamiliar interactions with others.\nTARDIS aims to build a scenario-based serious-game simulation platform for young people at risk of exclusion, aged 18-25, to explore, practice and improve their social skills. TARDIS will facilitate the interaction through virtual agents (VAs) acting as recruiters in job interviews scenarios. The VAs are designed to deliver realistic socio-emotional interactions and are credible, yet tireless interlocutors. TARDIS exploits the unique affordances of digital technology, by creating an environment in which the quality and the quantity of emotional display by the agents can be modulated to scaffold the young trainees through a diverse range of possible interview situations. The scenarios are co-designed with experienced practitioners in several European countries in order to ensure their relevance to the different individuals across a number of cultural contexts.\nTARDIS offers three major innovations. First, it will be able to detect in real-time users emotions and social attitudes through voice and facial expression recognition, and to adapt the progress of the game and the behaviour virtual interlocutors behaviour to the individual users. Second, it will provide field practitioners with an intuitive authoring tool for designing appropriate interview scenarios and for setting agents behaviours without the help of computer scientists. Third, it will give practitioners a unique access to a systematic record of the specific difficulties that the users experience. This will offer new instruments for practitioners to measure individuals progress in emotion regulation and social skill acquisition, thus facilitating reflection on their own practice and enabling a more flexible and personalised coaching for young people at risk of social exclusion.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2007.2.2 | Award Amount: 8.19M | Year: 2009

The field of robotics is undergoing a major revolution as it is increasingly being applied to general purposes outside the production line: for health, rehabilitation and professional services, in domestic and leisure environments, as well as hazardous environments. There, one keystone for robots to carry out accurate and intelligent tasks, with and for people, is their ability both to handle autonomously all sorts of objects and to use human tools. However, todays robots are unable to achieve dexterous and fine manipulation, especially when this requires in-hand manipulation. They are far from being able to understand and reason about their environments, their goals and their own capabilities, to learn skills and improve their performance by what they have been taught and their own experience, to interact with their environments with the efficiency of humans.\nThe HANDLE project aims at understanding how humans perform the manipulation of objects in order to replicate grasping and skilled in-hand movements with an anthropomorphic artificial hand, and thereby move robot grippers from current best practice towards more autonomous, natural and effective articulated hands. The project implies not only focusing on technological developments but also working with fundamental multidisciplinary research aspects in order to endow the robotic hand system with advanced perception capabilities, high level feedback control and elements of intelligence that allow recognition of objects and context, reasoning about actions and a high degree of recovery from failure during the execution of dexterous tasks.\nIntegrating findings from disciplines such as neuroscience, developmental psychology, cognitive science, robotics, multimodal perception and machine learning, the method we will develop is based on an original blend of learning and predicting behaviours from imitation and babbling to allow the robot to be capable of responding to gaps in its knowledge.

Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.41M | Year: 2013

CALIPSO is a genuine interdisciplinary and intersectorial research network composed of nine academic research institutions and three industrial partners, thus presenting an example of true translational research and training of young researchers in communicating and transferring achievements from different model organisms directly to industrial partners. CALIPSO aims at identifying environmentally triggered regulatory calcium signals and protein phosphorylation events that control photosynthesis and metabolism. CALIPSO partners work with a wide range of different organisms covering the full phylogenetic spectrum from algae to higher plants including economically important crops. They combine a wide spectrum of newest technologies in molecular biology, biochemistry, proteomics, metabolomics, genetics, bioinformatics and systems biology to uncover how photosynthetic organisms acclimate to changing environmental conditions or stress. This novel combination of scientific expertise combined with industrial applications is one of the major strengths of CALIPSO, exposing the participating researchers to different schools of thought. The active participation of Bayer CropScience Gent and Ecoduna as full network partners, and Photon Systems Instruments as associated partner, will enable intersectorial industry-academia cooperation with the long term objectives of (i) improving yield and stress robustness of crops and (ii) developing microalgal-biotechnology. The integrated systematic training programme of CALIPSO will boost the future employability of the young researchers by acquisition of technical skills for their work in academia or the private sector and also essential complementary skills for their future career. The training programme comprises three workshops on state-of-the art techniques - and one on industrial-relevant skills. This is completed by secondments to partner laboratories and industry and network-wide training events in further complementary skills.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.4.1 | Award Amount: 12.09M | Year: 2011

The SCAPE project will enhance the state of the art of digital preservation in three ways: by developing infrastructure and tools for scalable preservation actions; by providing a framework for automated, quality-assured preservation workflows and by integrating these components with a policy-based preservation planning and watch system. These concrete project results will be validated within three large-scale Testbeds from diverse application areas: Digital Repositories from the library community, Web Content from the web archiving community, and Research Data Sets from the scientific community. Each Testbed has been selected because it highlights unique challenges.SCAPE will develop scalable services for planning and execution of institutional preservation strategies on an open source platform that orchestrates semi-automated workflows for large-scale, heterogeneous collections of complex digital objects. These services will be able to:* Identify requirements for preserving all or parts of a repository through characterisation and trend analysis;* Define responses to those needs using formal descriptions of preservation policies and preservation plans;* Allow a high degree of automation, virtualization of tools, and scalable processing;* Monitor the quality of preservation processes.The SCAPE consortium brings together experts from memory institutions, data centres, research labs, universities, and industrial firms in order to research and develop scalable preservation systems that can be practically deployed within the project lifetime.Through a project extension in the final year, SCAPE will broaden its scope with respect to the utilized deployment models and infrastructures available to the project. New activities include the development of new scientific use-cases, advanced preservation services, and installations of the SCAPE environment in high performance computing (HPC) data centers. These use cases will further demonstrate the generic nature of the SCAPE approach and its applicability in the new Data Center Testbed.SCAPE is dedicated toward producing open source software solutions available to the entire digital preservation community. The project results will be curated and further exploited by the newly founded Open Planets Foundation. Project results will also be exploited by an SME and research institutions within the consortium catering to the preservation community and by two industrial IT partners.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.1.6 | Award Amount: 7.23M | Year: 2011

Experimentally-driven research is key to success in exploring the possible futures of the Internet. An open, general-purpose, shared experimental facility, both large-scale and sustainable, is essential for European industry and academia to innovate today and assess the performance of their solutions. OpenLab brings together the essential ingredients for such a facility. We extend early prototypes of testbeds, middleware, and measurement tools so as to provide more efficient and flexible support for a diverse set of experimental applications and protocols. The prototypes include a set of demonstrably successful testbeds: PlanetLab Europe, with its 153 partner/user institutions across Europe; the NITOS and w-iLab.t wireless testbeds; two IMS (IP Multimedia Subsystem) telco testbeds for exploring merged media distribution; a green networking testbed; the ETOMIC high precision network measurement testbed; and the HEN emulation testbed. Associated with these testbeds are similarly successful control- and experimental-plane software. OpenLab advances these prototypes with key enhancements in the areas of mobility, wireless, monitoring, domain interconnections, and the integration of new technologies such as OpenFlow. These enhancements will be transparent to existing users of each testbed, while opening up a diversity of new experiments that users can perform, extending from wired and wireless media distribution to distributed and autonomous management of new social interactions and localized services, going far beyond what can be tested on the current Internet. OpenLab results will advance the goal of a unified Future Internet Research and Experimentation (FIRE) facility. In addition, OpenLab can provide models for the Future Internet Public Private Partnership (FI-PPP). Finally, OpenLab will issue open calls to users in industry and academia to submit proposals for innovative experiments using the OpenLabs technologies and testbeds, and will devote one million euros to funding the best of these proposals.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2013.6.1-1 | Award Amount: 11.52M | Year: 2014

The ICE-ARC project aims to understand and quantify the multiple stresses involved in the change in the Arctic marine environment. Particular focus is on the rapid retreat and collapse of the Arctic sea ice cover and to assess the climatic (ice, ocean, atmosphere and ecosystem), economic and social impacts of these stresses on regional and global scales. It is not possible to look at one aspect of this system in isolation; a coupled atmosphere/cryosphere/ocean/ecosystem approach is needed. Our observations will focus on reducing the uncertainty in understanding of Arctic physical processes which are vital in climate and ecosystem change and which may not be adequately represented in present models. Results of the observational programme will be fed into an ice-ocean-atmosphere model which, after validation, will make projections - with reduced uncertainties - of the rate and nature of future changes in the ice cover, ocean structure and atmospheric temperature and circulation. In parallel with this an ecosystems model will perform the same role for marine living resources. The resulting projections of the two models will be fed into an economic impact model (PAGE-ICE) that is specially reconfigured for cryosphere-driven impacts. This will calculate the impacts of the projected physical changes upon the global economic and social system, including those of the Arctic region itself. This will be the first time that a leading global impact model has been coupled with a physical climate model to directly assess the economic impact of observed and projected climate change events. It is being applied to the oceanic region of greatest current concern to the global community because of the speed of visible change there. The outputs of the entire project, will undoubtedly lead to more effective policy and management options for societal responses to climate change, and because of this we have an extensive dissemination and engagement programme within ICE-ARC.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2009-2.4.4-1 | Award Amount: 7.77M | Year: 2009

Myasthenia Gravis (MG) is a heterogeneous rare autoimmune neurological disease affecting the neuromuscular junction (NMJ). The molecular events causing and maintaining MG are still unknown and current treatments do not lead to remission and entail considerable side-effects stressing the need for improved therapies. We will address the: 1. Natural course of disease: determine factors associated with disease onset and/or affecting the course of disease and patients quality of life in subgroups of MG patients including children, twins, females and elderly patients. 2. Etiology of MG: identify new genetic, epigenetic and environmental risk factors and investigate immunological key molecules associated with MG onset. 3. Pathogenic mechanisms at the NMJ: a) study molecular changes in the NMJ by proteomic, genetic, epigenetic and microRNA analyses in MG patients and experimental models; b) analyze morphological changes at the NMJ in mouse models expressing YFP nerves and mice transgenic for mini-agrin; c) evaluate the capacity of muscle cell satellites from MG patients to regenerate muscle and form new endplates in immunodeficient mice. 4. New diagnostic and monitoring assays: a) identify pathogenic and protective factors in MG sera; b) improve the sensitivity of current assays; c) Identify new biomarkers associated with different MG subgroups by proteomic and microRNA analyses; d) Identify patients response to treatment and liability to side effects by pharmacogenomic analyses. 5. Novel therapies: a) study new cell-based therapies aimed at regulating the autoimmune response by regulatory T cells or mesenchymal stem cells in humanized mice; b) immunoadsorb pathogenic antibodies; c) test non-cell based immmunomodulatory therapies; d) target epigenetic regulators. This multidisciplinary project linking basic researchers with clinical neurologists, SMEs and several European patient associations should favor a translational approach for improved MG management

Agency: Cordis | Branch: H2020 | Program: CSA | Phase: BG-11-2014 | Award Amount: 4.00M | Year: 2015

We are standing at the dawn of a century that will be largely affected by how we as a society are able to manage our oceans and their resources. Marine and Maritime Research has a critical role to play in developing our understanding of the seas and advance technology so that we can develop their economic potential in a sustainable manner. The COLUMBUS project intends to capitalise on the ECs significant research by ensuring accessibility and uptake of research Knowledge Outputs by end-users (policy, industry, science and wider society). COLUMBUS will ensure measurable value creation from research investments contributing to sustainable Blue Growth within the timeframe of the project. Adopting proven methodologies and building on significant past work, COLUMBUS will first identify end-user needs and priorities. It will then set about identifying and collecting Knowledge Outputs from past and current EC projects. Rigorous analysis will take place to identify specific applications and end-users. Transfer will be achieved and measured through tailor-made knowledge transfer. All knowledge collected will be made accessible the pre-existing Marine Knowledge Gate. To achieve the above, COLUMBUS has brought together a multi-disciplinary, multi-stakeholder team representing all aspects of the research value chain from funding agencies to end-users. Key strategic initiatives and networks further strengthen and provide a strong vehicle for project legacy. A network of 9 Competence Nodes, each with a Knowledge Fellow and support team across Europe will provide the necessary critical mass (470pm of effort) to ensure full thematic and spatial coverage. COLUMBUS will also carry out strategic actions to enhance the visibility and impact of research to stakeholders and European Citizens. Furthermore working with funding agencies and stakeholders, COLUMBUS will examine the feasibility of improved systems and processes to ensure measurable value creation from research.

Association Institute Of Myologie, University of Bern, University Pierre, Marie Curie, Institute National Of La Snate Et Of La Recherche Medicale and French National Center for Scientific Research | Date: 2012-10-12

The present invention relates to a nucleic acid molecule containing a sequence of tricyclo nucleosides joined by internucleoside phosphorothioate linkage. The invention also relates to synthetic antisense oligonucleotides and to methods employing the same.

University Pierre, Marie Curie and Essilor | Date: 2012-12-06

Method of determining configuration of interferential filtering elements for an optical device having an optical substrate for a user, includes:

French Institute of Health, Medical Research, Institute Gustave Roussy, Assistance Publique Hopitaux De Paris, Center Henri Becquerel, University of Paris Descartes, University Pierre, Marie Curie and University Paris - Sud | Date: 2016-06-08

The present invention concerns an in vitro method for diagnosing a myeloid tumour or a lymphoid tumour in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the Ten Eleven Translocation protein family member 2 gene (TET2) coding for the polypeptide having the sequence SEQ ID NO: 2, and/or (ii) analyzing the expression of the TET2 gene; wherein the detection of such a TET2 mutation, of the absence of expression of TET2 or of the expression of a truncated TET2 is indicative of a subject developing or predisposed to develop a myeloid tumour or a lymphoid tumour.

Association Institute Of Myologie, University Pierre, Marie Curie, French National Center for Scientific Research and Genethon | Date: 2011-03-22

Methods for increasing the efficiency of target tissue penetration of an adeno-associated virus (AAV) vector in a patient are provided. In some aspects, the methods involve inhibiting the interaction of the serum protein galectin 3 binding protein (G3BP) with AAV vector. Further provided are methods for reducing tissue distribution of a virus or for neutralizing a virus harbored by an organ destined for transplant, or newly transplanted, by administering a composition comprising G3BP.

University Pierre, Marie Curie, University Paris - Sud and French National Center for Scientific Research | Date: 2011-07-12

A process for depositing a layer on at least part of the surface of a substrate by at least partially submerging the substrate in a solution comprising a solvent and at least one compound intended to form the layer, then drying the substrate, this drying being at least partially carried out in an atmosphere that is isolated from the solution. The submersion in the solution and the drying of the substrate are carried out in the same controlled-atmosphere enclosure.

F-Interop will develop and provide remotely accessible tools to support and accelerate standardisation processes and products developments, by offsetting several cost and time barriers. It will research and develop a new FIRE experimental platform to support the development of new technologies and standards, from their genesis to the market for: online interoperability tests and validation tools, remote compliance and conformance tests, scalability tests, Quality of Service (QoS) tests, SDN/NFV interoperability tools, Online privacy test tools, energy efficiency tools. F-Interop gathers standardisation partners together with 3 FIRE federations (Fed4FIRE, IoT Lab, OneLab) to build a common experimental platform as a service. Following an end-user driven methodology, it will directly address the needs of 3 emerging standards: oneM2M led by ETSI, 6TiSCH (IETF) chaired by our Inria partner, Web of Things WG (start Feb 2015) led by W3C, our advisory board member. The open call will extend the platform to other standardisation activities, as well as to additional tools extensions and SME products validations. F-Interop will: - Provide online interoperability tools enabling research and development teams to test their products development and implementations at any time, without having to wait until the next face-to-face interop meeting. - Provide an online platform for standards compliance and labelling to be used by the IPv6 Forum Ready Logo Program and other similar labelling bodies, including ETSI, IETF and W3C. - Enable SME to accelerate interoperability and the development of their products and services. - Extend FIRE testbeds and bring them closer to the market. To achieve this ambitious objective, F.-Interop gathers a formidable combination of leading industry experts form standardisation bodies, research centres, FIRE testbeds and SMEs from Europe and Japan. The F-Interop Ecosystem will enable sustainable impact, commercial uptake and synergies at EU level.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.1.1 | Award Amount: 4.39M | Year: 2012

To support the booming demand in mobile 4G data services, the MOTO project proposes to design, dimension, implement, and evaluate a new network architecture in support of dynamic traffic offloading strategies to relieve a congested 4G/LTE network. Going far beyond present infrastructure based offloading approaches, MOTO explores an additional layer of disruptive offloading protocols that make use of direct terminal-to-terminal communications.MOTO definitely takes an operator point of view to opportunistic networking by keeping terminal based offloading under the control of the operators infrastructure. It explores and evaluates distributed offloading control protocols, it investigates coordination strategies between mobile and broadband Internet operators, it designs and implements a distributed trust and security policy, it derives formal capacity enhancements estimates and works toward understanding mobility and contact opportunities.MOTO adopts an experimental methodology, providing enhancements to an open source simulation environment, and carrying out practical experimentations on an operators large scale integrated testbed for architecture and protocol validation. The operators vision, requirements, and experience are backed by a strong team of experts in wireless networking technologies both from academia and industry.Thanks to MOTO offloading solutions, the operators will decide how much bandwidth to allocate for supporting crowds of users sharing data hungry services in a flexible and efficient way, and will be able to handle peaks of traffic without overprovisioning the infrastructure and without blocking the service to its users.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.1.6 | Award Amount: 3.25M | Year: 2010

NOVI (Networking innovations Over Virtualized Infrastructures) research concentrates on efficient approaches to compose virtualized e-Infrastructures towards a holistic Future Internet (FI) cloud service. Resources belonging to various levels, i.e. networking, storage and processing are in principle managed by separate yet interworking providers. NOVI will concentrate on methods, information systems and algorithms that will enable users with composite isolated slices, baskets of resources and services provided by federated infrastructures.\nNOVI will investigate federation at the data, control, monitoring and provisioning planes of constituent FI infrastructures. A user ideally expects seamless and secure access to virtual resources distributed across multiple domains. The complex nature of the federated infrastructure requires adoption of common definitions and abstractions of virtualized resources. Within this context, NOVI will propose and test resource description data models and abstraction algorithms, incorporating Semantic Web concepts. Predictable and accountable service delivery will be further addressed by investigating monitoring and resource brokerage methods in multi-domain virtualized infrastructures. Secure, authenticated access is a key requirement for a service cloud. NOVI will assess options of federated AAI schemas as they pertain to multi-domain FI environments.\nSome of the models and methods developed within NOVI are expected to enrich the FIRE facility, contributing to the creation of a blueprint of FI federated infrastructures. NOVIs research will be validated by deploying early prototypes on federating resources of virtualization platforms, initially PlanetLab Europe and FEDERICA. In fact the consortium includes key players of these two e-Infrastructures. NOVI participants (network research laboratories) will act as guinea pigs for experiments, promoting adoption by the wider FI community and substantiating input to standardization bodies.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.1.6 | Award Amount: 4.51M | Year: 2010

The main objective of the EULER exploratory research project is to investigate new routing paradigms so as to design, develop, and validate experimentally a distributed and dynamic routing scheme suitable for the future Internet and its evolution. The resulting routing scheme(s) is/are intended to address the fundamental limits of current stretch-1 shortest-path routing in terms of routing table scalability but also topology and policy dynamics (perform efficiently under dynamic network conditions). Therefore, this project will investigate trade-offs between routing table size (to enhance scalability), routing scheme stretch (to ensure routing quality) and communication cost (to efficiently and timely react to various failures). The driving idea of this research project is to make use of the structural and statistical properties of the Internet topology (some of which are hidden) as well as the stability and convergence properties of the Internet policy in order to specialize the design of a distributed routing scheme known to perform efficiently under dynamic network and policy conditions when these properties are met. The project will develop new models and tools to exhaustively analyse the Internet topology, to accurately and reliably measure its properties, and to precisely characterize its evolution. These models, that better reflect the network and its policy dynamics, will be used to derive useful properties and metrics for the routing schemes and provide relevant experimental scenarios. The project will develop appropriate tools to evaluate the performance of the proposed routing schemes on large-scale topologies (order of 10k nodes). Prototype of the routing protocols as well as their functional validation and performance benchmarking on the iLAB experimental facility and/or virtual experimental facilities such as PlanetLab/OneLab will allow validating under realistic conditions the overall behaviour of the proposed routing schemes.

Agency: Cordis | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2014 | Award Amount: 1.22M | Year: 2015

HYMADE focuses on the development of capsules and engineered colloidal particles for drug delivery combining mesoporous colloids, the Layer by Layer (LbL) technique and virosomes. The capsules and particles have potential applications in cancer and inflammatory diseases such as rheumatoid arthritis and uveitis. The project is based on the secondments of Early Stage Researchers and Experienced Researchers and networking and training activities between European and non European academic institutions. HYMADE aims to profit from the combination of hybrid materials to fabricate advanced drug delivery systems with controlled release and targeting efficiency of biological entities. The project also aims to gain understanding of the self assembly process of hybrid materials and the transport properties of the drug delivery systems.The biological fate, drug release, degradation and therapeutical efficiency of the drug delivery systems will be studied in vitro and in vivo with state of the art imaging techniques. To achieve these goals we have gathered an international multidisciplinary team with scientists at the forefront of Material Science, Self assembly, Physics, Chemistry, Biophysics and Imaging from Germany, Austria, France and Spain on the European side and from United States of America, Argentina and Armenia on the non European side.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-1.4-3 | Award Amount: 16.34M | Year: 2010

We propose to develop new strategies to mobilize skeletal muscle tissue-associated stem cells as a tool for efficient tissue repair. This will be combined with exploring novel approaches that limit tissue damage, and will focus on agents that modify muscle and muscle vasculature progenitor cells. These molecules include nitric oxide associated with non-steroidal anti-inflammatory drugs, HMGB1, Cripto, NAC, and present and improved deacetylase inhibitors. Three clinical trials will be run in tandem with efforts to dissect the underlying mechanisms of action. Importantly, we have already initiated a monocentric clinical trial that focuses on the efficacy of NO-donors plus NSAIDs in muscle pathologies. Our efforts will be complemented by novel biodelivery systems for effective targeting. Our efforts will be complemented by novel biodelivery systems for effective targeting. The most promising drugs, used alone or in combination, will be first validated in small and large animal models. Our project brings together leading investigators to examine how vascular and muscle progenitors participate in postnatal growth and muscle tissue repair. A key issue that this project addresses is the tissue environment in which endogenous stem cells are activated. We propose that muscle degeneration and fibrosis provokes altered vascularization and immune responses, which eventually affect negatively stem cell functions. Molecules that can be used to therapeutically target these key cells, and their communication with neighboring vascular, inflammatory and fibrotic cell types, will lead to more effective approaches to muscle regenerative medicine and to novel cures for degenerative diseases, including atherosclerosis, vascular damage in diabetes and in peripheral ischemic vascular disease.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.1.6 | Award Amount: 11.07M | Year: 2012

A federation of experimentation facilities will significantly accelerate Future Internet research. Fed4FIRE will deliver open and easily accessible facilities to the FIRE experimentation communities, which focus on fixed and wireless infrastructures, services and applications, and combinations thereof. The project will develop a demand-driven common federation framework, based on an open architecture and specification. It will be widely adopted by facilities and promoted internationally. This framework will provide simple, efficient, and cost effective experimental processes built around experimenters and facility owners requirements. Insight into technical and socio-economic metrics, and how the introduction of new technologies into Future Internet facilities influences them, will be provided by harmonized and comprehensive measurement techniques. Tools and services supporting dynamic federated identities, access control, and SLA management will increase the trustworthiness of the federation and its facilities. A FIRE portal will offer brokering, user access management and measurements. Professional technical staff will offer first-line and second-line support to make the federation simple to use. The project will use open calls to support innovative experiments from academia and industry and to adapt additional experimentation facilities for compliance with Fed4FIRE specifications. A federation authority will be established to approve facilities and to promote desirable operational policies that simplify federation. A Federation Standardization Task Force will prepare for sustainable standardization beyond the end of the project. The adoption of the Fed4FIRE common federation framework by the FIRE facilities, the widespread usage by both academic and industrial experimenters, and the strong links with other national and international initiatives such as the FI-PPP, will pave the way to sustainability towards Horizon 2020.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-22-2014 | Award Amount: 3.80M | Year: 2015

The visually impaired and the elderly, often suffering from mild speech and/or motor disabilities, are experiencing a significant and increasing barrier in accessing ICT technology and services. Yet, in order to be able to participate in a modern, interconnected society that relies on ICT technologies for handling everyday issues, there is clear need also for these user groups to have access to ICT, in particular to mobile platforms such as tablet computers or smart-phones. The proposed project aims at developing and exploiting the recently matured and quickly advancing biologically-inspired technology of event-driven, compressive sensing (EDC) of audio-visual information, to realize a new generation of low-power multi-modal human-computer interface for mobile devices. The project is based on two main technology pillars: (A) an air gesture control set, and (B) a vision-assisted speech recognition set. (A) exploits EDC vision for low and high level hand and finger gesture recognition and subsequent command execution; (B) combines temporal dynamics from lip and chin motion acquired using EDC vision sensors with the auditory sensor input to gain robustness and background noise immunity of spoken command recognition and speech-to-text input. In contrast to state-of-the-art technologies, both proposed human-computer communication channels will be designed to work reliably under uncontrolled conditions. Particularly, mobile devices equipped with the proposed interface technology will facilitate unrestricted outdoor use under uncontrolled lighting and background noise conditions. Furthermore, due to the sparse nature of information encoding, EDC excels conventional approaches in energy efficiency, yielding an ideal solution for mobile, battery-powered devices. ECOMODE is committed to pave the way for industrialization of commercial products by demonstrating the availability of the required hardware and software components and their integrability into a mobile platform.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: NMP.2011.1.4-4 | Award Amount: 5.16M | Year: 2012

NeuroCare aims to create better retinal, cortical and cochlear implantable devices through the use of improved interfacing between the electronic implants and living cells. The NeuroCare concept involves low-cost, carbon-based materials, well-adapted for medical implants, because they (i) offer wide range of electronic properties (metal, semiconductor and insulator), (ii) are bio-inert and (iii) are physically robust. Coupling between electronic devices and neurons was recently studied using soft, nanocrystalline diamond-based micro-electrode arrays, evaluated in laboratory animals for retinal stimulation. These diamond implants considerably reduced gliosis, enabled stimulation currents to be raised by more than one order of magnitude before causing visible chemical alteration, and enabled long lasting operation with reduced biofouling. Our previous experience with nanocrystalline diamond will be directly built upon through the introduction of atomic layers of graphene to diamond surfaces. NeuroCare will specifically focus on: Carbon-biointerface development offering reduced biofouling over the state-of-the-art, as set by the DREAMS project and improved biocompatibility Interfacing of rigid MEAs and FETs with cells and organs to improve bidirectional communication with neurons for in vitro research and pharmacological applications Nanoscale surface engineering and flexible macroscale implant materials for optimal contact to biological tissue Making and testing implantable MEAs and FETs for complex multichannel neuronal communication - targeting the specificity in vivo of the implantable devices for 3 high-impact clinical applications Neurocare partners will test interfaceable and implantable devices via in vitro and in vivo testing. NeuroCare federates 12 partners: CEA (LIST and CLINATEC), Ecole Suprieure dIngnieurs en Electronique, Forschungszentrum Jlich, Ayanda Biosystems SA, University College London (London Centre for Nanotechnology), Johannes

Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-ITN-2008 | Award Amount: 4.28M | Year: 2009

The discovery of Bose-Einstein condensation (BEC) of exciton-polaritons in 2006 and the demonstration of room-temperature polariton lasing in 2007 have opened the way to realisation of a new generation of optoelectronic devices referred to as polariton devices. The research on exciton-polaritons and polaritonics allows the quantum effects of superfluidity, entanglement, squeezing of light to be brought to the everyday life and used in new light sources, optical switches, modulators and memory elements. The fundamental principles of polariton physics have been established by our previous networks CLERMONT and CLERMONT2 within the 5th and 6th FP. The breakthrough achieved in 2006-2007 brings the polaritonics on a new level and makes its rapid development in Europe an overall strategic priority. Our present consortium composed by 10 European academic teams and supported by 6 leading industrial groups has a critical mass in polariton physics and technology. We intend to form a new generation of solid state physicists able to maintain the European leadership in this rapidly developing interdisciplinary research field. Four of the present partners took part in the discovery of the BEC of polaritons and polariton lasing, six others have given key contributions into polaritonics over the last decade. The Coordinator of the project holds the Marie Curie Chair of Excellence Polariton Devices at the university of Rome. We propose 16 full term PhD and 3 postdoc projects to be realized at two network nodes each with a compulsary training in industry. We shall organize the international conference on Optics of Excitons in Confined Systems in 2009, 3 international conferences on Physics of Light-Matter Coupling in Nanostructures and 2 Summer Schools on Nanophotonics. The project will form a world-leading international team of researchers capable to implement the ideas of polaritonics in a new generation of optoelectronic devices.

NACLIM aims at investigating and quantifying the predictability of the climate in the North Atlantic/European sector related to North Atlantic/Arctic sea surface temperature (SST) and sea ice variability and change on seasonal to decadal time scales. SST and sea-ice forcing have a crucial impact on weather and climate in Europe. Rather than running climate forecasts ourselves, we will analyze the multi-model decadal prediction experiments currently performed as part of the fifth Coupled Model Intercomparison Project (CMIP5) and critically assess the quality of predictions of the near-future state of key oceanic and atmospheric quantities relevant to the SST and sea-ice distribution and the related climate. Long-term observations of relevant ocean parameters will be carried out, necessary to assess the forecast skill of the model-based prediction results. We will identify those observations that are key to the quality of the prediction and in turn optimize the present observing system. We will quantify the impact of North Atlantic/European climate change on high trophic levels of the oceanic ecosystem as well as on urban societies.

Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: HEALTH.2013.4.1-4 | Award Amount: 554.66K | Year: 2013

Diabetes, Cardiovascular and Chronic kidney (DCC) -diseases are relentlessly increasing globally, causing enormous human suffering, premature deaths and unsustainable costs. Leading European research has indisputably pointed that the kidney filtration barrier and its epithelial cell, the podocyte, is a common denominator for the DCC-diseases. However, European excellence and expertise have remained uncoordinated in separate pockets and, consequently, underutilised for full societal benefits and capacity creation to combat the challenges of diabetic, hypertensive and primary kidney diseases. Notably, these diseases are of major healthcare interest and of key importance for discovery intensive biopharma industry. KidneyConnect brings together teams of excellence to underpin nationally funded programs under a) Discovery and Future Technologies b) New Research Platforms c) Translational and d) Clinical Podocyte Research to create connected capacities, access to well trained talents and to optimize strategies for industry-academia cowork. In addition to resource maps, KidneyConnect supports international congresses, training courses, talent coaching, special seminars and builds systematically relations to key stakeholders. Due to the limited funds available, main aims are to provide roadmaps for future efforts, outlines for shared data -and sample repositories, targeted training, societal outreach and, as a result, competitive European funded programs. Our events are arranged as satellites of established meetings and supported by in-kind contribution from partners. The goal is to establish faster translation from discovery to clinical practices by creating dynamic networks, sustainable capacities and outlines for improved kidney disease management. High cohesion and shared resources together with the most prominent European authorities included will guarantee optimized resource usage. Substantial benefits and competitiveness in the huge global markets are to be expected

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2007.8.0 | Award Amount: 2.09M | Year: 2008

In the recent years, continuous variables (CV) have emerged as a viable and very promising alternative to the traditional quantum bit-based approaches to quantum information processing. Encoding CV information onto mesoscopic carriers such as the quadratures of light modes or the collective spin of atoms offers several distinct advantages, such as the deterministic generation and manipulation of entangled states of light and atomic ensembles, or the interface between light and atoms allowing the implementation of a quantum memory. This toolbox of available operations has recently been significantly extended by conditional photon subtraction, which allows the generation of highly non-classical states with negative Wigner functions. This opens access to the realm of non-Gaussian operations, which are essential to several critical applications such as CV entanglement distillation or CV quantum computing. By building on these recent spectacular achievements, the present project aims at carrying out exploratory research on mesoscopic CV quantum information systems, with the ambitious ultimate objective of designing the first small-scale quantum processor using this CV toolbox. In an interplay between theory and experimental research, the consortium will investigate the hitherto unexplored potential of CV quantum computing and will address all necessary steps on the way to mesoscopic CV processors. This includes the engineering of non-Gaussian operations on photonic and atomic states exploiting the measurement-induced or actual nonlinearities between light and atoms, CV quantum computing with cat states or cluster states, CV entanglement distillation, error correction, and quantum repeaters. It is anticipated that the present project will have a strong impact on the future of ICT-related technologies and further strengthen the pan-European cooperation in a research area where Europe has started to establish itself at the leading edge.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: ENV.2010.1.1.3-1 | Award Amount: 9.56M | Year: 2011

CARBOCHANGE will provide the best possible process-based quantification of net ocean carbon uptake under changing climate conditions using past and present ocean carbon cycle changes for a better prediction of future ocean carbon uptake. We will improve the quantitative understanding of key biogeochemical and physical processes through a combination of observations and models. We will upscale new process understanding to large-scale integrative feedbacks of the ocean carbon cycle to climate change and rising carbon dioxide concentrations. We will quantify the vulnerability of the ocean carbon sources and sinks in a probabilistic sense using cutting edge coupled Earth system models under a spectrum of emission scenarios including climate stabilisation scenarios as required for the 5th IPCC assessment report. The drivers for the vulnerabilities will be identified. The most actual observations of the changing ocean carbon sink will be systematically integrated with the newest ocean carbon models, a coupled land-ocean model, an Earth system model of intermediate complexity, and fully fledged Earth system models through a spectrum of data assimilation methods as well as advanced performance assessment tools. Results will be optimal process descriptions and most realistic error margins for future ocean carbon uptake quantifications with models under the presently available observational evidence. The project will deliver calibrated future evolutions of ocean pH and carbonate saturation as required by the research community on ocean acidification in the EU project EPOCA and further projects in this field. The time history of atmosphere-ocean carbon fluxes past, present, and future will be synthesised globally as well as regionally for the transcontinental RECCAP project. Observations and model results will merge into GEOSS/GEO through links with the European coordination action COCOS and will prepare the marine branch of the European Research Infrastructure ICOS.

Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.87M | Year: 2013

Organic thin-films constitute a fast growing area of electronic and opto-electronic devices that offer cost-effective and flexible solutions for e.g. improved energy efficiency and energy harvesting. Due to the achievements made during the past decade, the development of such sustainable energy devices has already reached an early commercialization stage, however, in order to further boost their uptake on the market, improvement of device efficiency and lifetime is still needed. Such improvement requires a profound knowledge about fundamental properties of thin-film hybrid interfaces and their implementation in devices a knowledge that is already requested from established and new companies focusing on organic electronic and opto-electronic devices. With this project, we establish a network that trains and educates young researchers within the area of hybrid thin-film interfaces for sustainable energy devices. In order to provide training and education that are of both high quality and of relevance for the market, the research training programmes are in this consortium based on a combination of state-of-the-art research and industrial development and production processes. The consortium consists of 5 full university partners, 1 research organization, 2 full industry partners, 4 associate industry partners and 1 associate research organization. The partners in the consortium are deliberately chosen in order to build up a unique cluster between universities and companies. Such cluster provides the young researchers in the consortium strong competence on 1) state-of-the-art research, 2) innovation and entrepreneurship and 3) large through-put industrial production processes. The training network combines expertise on modeling, thin-film formation, device fabrication and characterization (multidisciplinary aspect) in order to provide solutions for a range of different sustainable energy applications such as thin-film transistors and solar cells (intersectoral aspect).

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-2.3.2-4 | Award Amount: 15.44M | Year: 2010

Despite significant effort over the past decade to design and implement new vaccines strategies against HIV, no one has met its promise to prevent infection and/or to reduce viral load until reaching eradication of the HIV reservoir. To reach this goal, a translational research is critical to propose innovative approaches for an HIV vaccine enhancing broadly cross-reactive mucosal, humoral and cellular immune responses specific to HIV antigens. Composed by 13 partners from 5 European countries and 2 International Cooperation countries, the CUTHIVAC consortium gathers knowledges and cutting-edge technologies in vaccinology and HIV diseases to raise the challenge of developing a new HIV strategy. The CUTHIVAC approach is based on innovative transcutaneous and/or mucosal needle-free vaccination methods in a perspective that new vaccine candidates will redirect immune response toward cytotoxic CD8 and mucosal humoral responses. The trust of the project derives from the proof-of-concept that combination of routes of immunization and delivery systems will shape the immune responses towards its protective arms against HIV. Clinical trials will be implemented with last cutting-edge generation of HIV DNA-GTU candidate applied by transcutaneous, intradermal routes and/or mucosal administration of HIV-envelop protein-based vaccine. Large efforts will be positioned on the new genetic design of HIV antigens and delivery systems for developed and developing countries. These new vaccines will be tested in innovative preclinical approaches with a special highlight on routes of vaccination that will be translated into 2nd round of clinical trials in a perspective that could help to prevent and eradicate HIV. Through its integrative and multidisciplinary approach, CUTHIVAC will therefore provide the basis for a novel approach in vaccination with a view to wide its application to other infectious diseases such as malaria and tuberculosis.

Agency: Cordis | Branch: FP7 | Program: ERC-AG | Phase: ERC-AG-PE9 | Award Amount: 2.50M | Year: 2011

This interdisciplinary proposal spans theoretical astrophysics and particle physics by addressing the need to provide astrophysical expertise to the particle astrophysics community in the area of dark matter and dark energy research. A new dialogue will be developed via collaborations involving expertise in astronomy, statistics and particle physics that centre on fundamental aspects of the nature of the contents of the universe. Theoretical predictions will be refined to pursue the quest for dark matter using novel experiments designed to detect the direct signatures of dark matter in our galactic halo via scattering and indirect via annihilations into high energy particles and photons. Dark matter and dark energy will be studied by cosmic microwave background temperature fluctuations and structure formation constraints. The former probe is contaminated by inadequately understood foregrounds that will be examined to extract clues to new physics in the very early universe, an especially timely research frontier in view of the anticipated data from the Planck satellite. The latter is rendered difficult by the highly complex interface of star and galaxy formation. This will be studied by emphasizing development of feedback prescriptions, an ingredient that plays a central role in the current paradigm for galaxy formation and complements ultradeep searches with the new generation of telescopes. The overall goal, namely to leverage via theory on the unprecedented experimental efforts that are underway to address dark sector issues in the emerging field of particle astrophysics, is achievable at relatively modest cost.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP-2007-4.0-4 | Award Amount: 14.37M | Year: 2008

The search for effective therapies and early detection strategies for Alzheimers Disease (AD), the major cause of dementia in Europe, is imperative. It is known that -amyloid (A) peptide plays a central role in neurodegeneration. In AD brain, A is released in a soluble form that progressively becomes insoluble forming aggregates; extracellular plaques mainly composed of A are a hallmark of post-mortem brains. These premises strongly suggest brain A as a possible target for therapy and diagnosis of AD. In addition, it is known that brain and blood A pools are in equilibrium via the blood-brain-barrier (BBB). Accordingly, it has been reported that removal of blood A may withdraw the excess of brain A by a sink effect. Thus, blood A is another potential target. The aim of this project is to utilize nanoparticles (NPs) specifically engineered for targeting brain A, for the combined diagnosis and therapy (theranostics) of AD. NPs (liposomes, solid lipid NPs, polymeric-NPs) will be multiple-functionalized with: i) a large arsenal of molecules (specific lipids, antiamyloidogenic drugs, polyphenols, heteroaromatic compounds, unnatural peptides and peptidomimetics, antibodies) interacting with A in all aggregation forms, ii) PET or MRI contrast agents detecting such interaction, iii) molecules stimulating BBB crossing via the transcytotic route. Several artificial and cellular models will be used to fine-tune such features and to improve NPs biocompatibility, non-immunogenicity, non-toxicity and physical stability. Eventually, absorption, distribution, metabolism and excretion will be studied using animal models of AD. Different routes (i.v., oral, nasal) and protocols (two-step, NPs cocktails, aerosols) of administration will be utilized to boost NPs brain delivery. The prediction is that NPs will detect, disaggregate and remove A brain deposits. In any case, NPs will interact with blood A, withdrawing the excess of brain peptide by a sink effect.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2007.1.1 | Award Amount: 3.64M | Year: 2008

Networks require greater degree of service-awareness. This implies that not only are all digital items pertaining to a service delivered, but also all relevant business goals are fulfilled, and network resources are used optimally. As a consequence the networks complexity grows with service abundance placing new requirements on network control and management as well as on Internet network resource usage.\nAutonomic Internet (AutoI) aspires to be such a solution. It will design and develop a self-managing virtual resource overlay that can span across heterogeneous networks, support service mobility, quality of service and reliability. The overlay will self-manage based on the business-driven service goals changes (service context) and resource environment changes (resource context). Accordingly, AutoI, suggests a transition from a service agnostic Internet to service-aware network resources by means of Virtualising network resources and Policy-Based Management techniques to describe and control the internal service logic, utilising Ontology-based information and data models to facilitate the Internet service deployment in terms of programmable networks facilities supporting NGN.\nFinally, aiming at the unification in autonomics, AutoI is aligned with the international standard group Autonomic Communications Forum (ACF) objectives, which will provide AutoI the platform for transforming results into standards.

Agency: Cordis | Branch: H2020 | Program: CSA | Phase: INT-01-2015 | Award Amount: 1.06M | Year: 2016

Mesopelagic Southern Ocean Prey and Predators The underlying concept of MESOPP is the creation of a collaborative network and associated e-infrastructure (marine ecosystem information system) between European and Australian research teams/institutes sharing similar interests in the Southern Ocean and Antarctica, its marine ecosystem functioning and the rapid changes occurring with the climate warming and the exploitation of marine resources. While MESOPP will focus on the enhancement of collaborations by eliminating various obstacles in establishing a common methodology and a connected network of databases of acoustic data for the estimation of micronekton biomass and validation of models, it will also contribute to a better predictive understanding of the SO based on furthering the knowledge base on key functional groups of micronekton and processes which determine ecosystem dynamics from physics to large oceanic predators. This first project and associated implementation (science network and specification of an infrastructure) should constitute the nucleus of a larger international programme of acoustic monitoring and micronekton modelling to be integrated in the general framework of ocean observation following a roadmap that will be prepared during the project.

There is strong interest in the development of novel functionalized membranes which can be used as microsieves, as a component of integrated analytical systems, in food processing, drug discovery and diagnostic applications. This project is based on a combination of three break-through technologies, developed by the applicants in the past, with high impact for nano(bio)technological application: (i) the S-layer technology allowing the construction of nanoporous protein lattices, (ii) the biocatalytic formation of inorganic materials by silicatein, a group of unique enzymes capable to catalyze the formation of porous silica from soluble precursors, and (iii) the sol-gel technique for encapsulation (immobilization) of biomolecules serving as biocatalyst or as a component of sensors. The goal of this project is to design and fabricate - based on molecular biology inspired approaches - nano-porous bio-inorganic membranes with novel functionalities for industrial application. These membranes will be formed by S-layer proteins, which are able to assemble to highly ordered structures of defined pore-size, and recombinant silicateins or silicatein fusion proteins. The hydrated silica glass layer formed by silicatein will be used to encase biocatalysts (enzymes) or antibodies against small molecules as sample prep- or sensor components of integrated systems. The innovative type of the functionalized membranes developed in this project thus exploits two principles: (i) protein self-assembly and - and this has not been done before - (ii) enzymatic (silicatein-mediated) deposition of inorganic material used for reinforcement of the membranes as well as for encasing biomolecules, providing the membranes with new functionalities. The new technique will be exploited by three research-based SMEs and the enduser involved in the project, in microfluidics based sample processing and micro-array development, in industrial nanosieves, as well as in sensors in drinking water systems.

Stemmann L.,University Pierre and Marie Curie | Boss E.,University of Maine, United States
Annual Review of Marine Science | Year: 2012

Understanding pelagic ecology and quantifying energy fluxes through the trophic web and from the surface to the deep ocean requires the ability to detect and identify all organisms and particles in situ and in a synoptic manner. An idealized sensor should observe both the very small living or dead particles such as picoplankton and detritus, respectively, and the large particles such as aggregates and meso- to macroplankton. Such an instrument would reveal an astonishing amount and diversity of living and nonliving particles present in a parcel of water. Unfortunately such sensors do not exist. However, complex interactions constrain the space, temporal, and size distributions of these objects in such ways that general rules can be inferred from the measurement of their optical properties. Recent technological developments allow for the in situ measurement of the optical properties and size distributions of particles and plankton in a way such that synoptic surveys are possible. This review deals with particle and plankton size distributions (PSDs) as well as how particles' geometry and nature affect their optical properties. Finally, we propose the integration of the PSD into size-structured mathematical models of biogeochemical fluxes. © Copyright © 2012 by Annual Reviews. All rights reserved.

Bazin D.,University Paris - Sud | Bazin D.,University Pierre and Marie Curie | Daudon M.,APHP | Combes C.,National Polytechnic Institute of Toulouse | Rey C.,National Polytechnic Institute of Toulouse
Chemical Reviews | Year: 2012

A study was conducted to investigate characterization and some physicochemical aspects of pathological microcalcifications of calcium salts encountered in pathological calcifications and the role of proteins in these processes. The investigations showed the different levels of complexity of pathological calcifications, revealing that such biological entities were present everywhere in the human body. Their origin was complex and was induced by different kinds of abnormalities. It was also revealed that such pathological calcifications had a hierarchical structural organization, which was related to the history of the patient. The study highlighted different specific structural aspects of pathological calcification by scanning electron microscopy (SEM) observations related to major medical aspects. The observations proposed that a morphologic examination be performed before compositional analysis by means of X-ray diffraction or infrared spectroscopy, as this direct SEM examination constituted a simple, rapid, and cheap tool.

Association Institute Of Myologie, French National Center for Scientific Research, University Pierre and Marie Curie | Date: 2012-03-12

An isolated linear nucleic acid molecule comprising in this order: a first adeno-associated virus (AAV) inverted terminal repeat (ITR), a nucleotide sequence of interest and a second AAV ITR, wherein said nucleic acid molecule is devoid of AAV capsid protein coding sequences. The said nucleic acid molecule can be applied to a host at repetition without eliciting an immune response. Methods for producing and purifying this nucleic acid molecule, and use of the same for therapeutic purposes are also provided.

Association Institute Of Myologie, French National Center for Scientific Research, French Institute of Health, Medical Research, University Pierre and Marie Curie | Date: 2010-10-08

The present invention provides methods and compositions for generating novel nucleic acid molecules through targeted spliceosome mediated simple or double trans-splicing. The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and to mediate a simple or double trans-splicing reaction resulting in the generation of a novel chimeric RNA molecule (chimeric RNA).

Assistance Publique Hopitaux De Paris Aphp, University of Paris Descartes, University Pierre, Marie Curie, University Paris Diderot, University Paris - Sud and Institute Gustave Roussy | Date: 2014-10-03

The present invention provides novel methods for the modulation of autophagy and the treatment of autophagy-related diseases, including cancer, neurodegenerative diseases, liver diseases, muscle diseases and pancreatitis.

Essilor, University Pierre and Marie Curie | Date: 2012-12-06

An optical device including an optical substrate including a first surface having a first zone provided with first selective interferential filtering element for selectively inhibiting transmission of incident light based on the wavelength spectrum of the incident light, the first selective interferential filtering being configured to inhibit, at a first rate of rejection, transmission of a first selected range of wavelengths of incident light, incident on the first zone within a first selected range of angles of incidence, wherein the first selected range of angles of incidence is determined based on at least one main line of sight of a user.

Association Institute Of Myologie, Genethon, University Pierre, Marie Curie and French National Center for Scientific Research | Date: 2010-07-30

The present invention relates to compositions and methods, in particular to methods based on systemic administration of scAAV, for delivering genes to cells of the retina of mammals, and in particular to photoreceptor cells, ganglion cells, glial cells, inner nuclear layer cells or cells of the retinal pigmented epithelium.

University Pierre, Marie Curie and Association Institute Of Myologie | Date: 2010-10-08

The present invention provided methods and compositions for generating novel nucleic acid molecules through targeted spliceosome mediated simple or double trans-splicing. The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and to mediate a simple or double trans-splicing reaction resulting in the generation of a novel chimeric RNA molecule (Chimeric RNA).

Ribeiro P.,University of Lisbon | Mosseri R.,University Pierre and Marie Curie
Physical Review Letters | Year: 2011

We discuss the entanglement properties of symmetric states of n qubits. The Majorana representation maps a generic such state into a system of n points on a sphere. Entanglement invariants, either under local unitaries (LU) or stochastic local operations and classical communication (SLOCC), can then be addressed in terms of the relative positions of the Majorana points. In the LU case, an overcomplete set of invariants can be built from the inner product of the radial vectors pointing to these points; this is detailed for the well-documented three-qubits case. In the SLOCC case, a cross ratio of related Möbius transformations are shown to play a central role, exemplified here for four qubits. Finally, as a side result, we also analyze the manifold of maximally entangled 3 qubit state, both in the symmetric and generic case. © 2011 American Physical Society.

Henao D.,University Pierre and Marie Curie | Mora-Corral C.,Basque Center for Applied Mathematics
Archive for Rational Mechanics and Analysis | Year: 2010

In this paper, we present and analyze a variational model in nonlinear elasticity that allows for cavitation and fracture. The main idea in unifying the theories of cavitation and fracture is to regard both cavities and cracks as phenomena of the creation of a new surface. Accordingly, we define a functional that measures the area of the created surface. This functional has relationships with the theory of Cartesian currents. We show that the boundedness of that functional implies sequential weak continuity of the determinant of the deformation gradient, and that the weak limit of one-to-one almost everywhere deformations is also one-to-one almost everywhere. We then use these results to obtain the existence of minimizers of variational models that incorporate elastic energy and this created surface energy, taking into account orientation-preserving and non-interpenetration conditions. © 2009 Springer-Verlag.

Cazabat A.-M.,University Pierre and Marie Curie | Guena G.,University of Rennes 1
Soft Matter | Year: 2010

This review is aimed at presenting the evaporation of macroscopic sessile droplets on inert substrates in normal atmosphere in simple cases, as a basis for more complex analyses. © 2010 The Royal Society of Chemistry.

Crouzeix M.,University of Rennes 1 | Combescot M.,University Pierre and Marie Curie
Physical Review Letters | Year: 2011

This Letter provides the solution to a yet unsolved basic problem of solid state physics: the ground state energy of an arbitrary number of Cooper pairs interacting via the Bardeen-Cooper-Schrieffer potential. We here break a 50 yr old math problem by analytically solving Richardson-Gaudin equations which give the exact energy of these N pairs via N parameters coupled through N nonlinear equations. Our result fully supports the standard BCS result obtained for a pair number equal to half the number of states feeling the potential. More importantly, it shows that the interaction part of the N-pair energy depends on N as N(N-1) only from N=1 to the dense regime, a result which evidences that Cooper pairs interact via Pauli blocking only. © 2011 American Physical Society.

Brennan B.,Royal Manchester Childrens Hospital | Stiller C.,Childhood Cancer Research Group | Bourdeaut F.,University Pierre and Marie Curie
The Lancet Oncology | Year: 2013

Extracranial rhabdoid tumours are rare, and often occur in infants. Although the kidney is the most common site, they can occur anywhere in the body. Most contain a biallelic inactivating mutation in SMARCB1, which is part of the chromatin remodelling complex SWI/SNF, and functions as a classic tumour suppressor gene. Despite multimodal therapy, outcome in rhabdoid tumours remains poor with only 31% of patients surviving to 1 year. The young age of patients limits use of radiotherapy, which, along with age, is an important prognostic factor. Because the tumours are rare, no standard therapeutic pathway exists, and no randomised trials have examined the role of new therapeutic approaches. Improved understanding of the biology and role of SMARCB1 has enabled identification of new targets for small molecule inhibitors to combine with chemotherapy backbones that we might establish from the current EpSSG and COG studies. © 2013 Elsevier Ltd.

Datchi F.,University Pierre and Marie Curie | Mallick B.,University Pierre and Marie Curie | Salamat A.,European Synchrotron Radiation Facility | Ninet S.,University Pierre and Marie Curie
Physical Review Letters | Year: 2012

The structure of polymeric carbon dioxide (CO 2-V) has been solved using synchrotron x-ray powder diffraction, and its evolution followed from 8 to 65 GPa. We compare the experimental results obtained for a 100% CO 2 sample and a 1 mol% CO 2/He sample. The latter allows us to produce the polymer in a pure form and study its compressibility under hydrostatic conditions. The high quality of the x-ray data enables us to solve the structure directly from experiments. The latter is isomorphic to the β-cristobalite phase of SiO 2 with the space group I4̄2d. Carbon and oxygen atoms are arranged in CO 4 tetrahedral units linked by oxygen atoms at the corners. The bulk modulus determined under hydrostatic conditions, B 0=136(10)GPa, is much smaller than previously reported. The comparison of our experimental findings with theoretical calculations performed in the present and previous studies shows that density functional theory very well describes polymeric CO 2. © 2012 American Physical Society.

Mingozzi F.,Children's Hospital of Philadelphia | Mingozzi F.,University Pierre and Marie Curie | High K.A.,Children's Hospital of Philadelphia | High K.A.,Howard Hughes Medical Institute | High K.A.,University of Pennsylvania
Blood | Year: 2013

Gene therapy products for the treatment of genetic diseases are currently in clinical trials, and one of these, an adeno-associated viral (AAV) product, has recently been licensed. AAV vectors have achieved positive results in a number of clinical and preclinical settings, including hematologic disorders such as the hemophilias, Gaucher disease, hemochromatosis, and the porphyrias. Because AAV vectors are administered directly to the patient, the likelihood of a host immune response is high, as shown by human studies. Preexisting and/or recall responses to the wild-type virus from which the vector is engineered, or to the transgene product itself, can interfere with therapeutic efficacy if not identified and managed optimally.Small-scale clinical studies have enabled investigators to dissect the immune responses to the AAV vector capsid and to the transgene product, and to develop strategies to manage these responses to achieve long-term expression of the therapeutic gene. However, a comprehensive understanding of the determinants of immunogenicity of AAV vectors, and of potential associated toxicities, is still lacking. Careful immunosurveillance conducted as part of ongoing clinical studies will provide the basis for understanding the intricacies of the immune response in AAV-mediated gene transfer, facilitating safe and effective therapies for genetic diseases. © 2013 by The American Society of Hematology.

Kruta I.,CNRS Center for Research on Palaeobiodiversity and Palaeoenvironments | Landman N.,American Museum of Natural History | Rouget I.,University Pierre and Marie Curie | Cecca F.,University Pierre and Marie Curie | Tafforeau P.,European Synchrotron Radiation Facility
Science | Year: 2011

Ammonites are prominent in macroevolutionary studies because of their abundance and diversity in the fossil record, but their paleobiology and position in the marine food web are not well understood due to the lack of preserved soft tissue. We present three-dimensional reconstructions of the buccal apparatus in the Mesozoic ammonite Baculites with the use of synchrotron x-ray microtomography. Buccal mass morphology, combined with the coexistence of food remains found in the buccal mass, suggests that these ammonites fed on plankton. This diet may have extended to all aptychophoran ammonites, which share the same buccal mass morphology. Understanding the role of these ammonites in the Mesozoic food web provides insights into their radiation in the Early Jurassic, as well as their extinction at the end of the Cretaceous/early Paleogene.

Henao D.,University Pierre and Marie Curie | Mora-Corral C.,Basque Center for Applied Mathematics
Archive for Rational Mechanics and Analysis | Year: 2011

Motivated by nonlinear elasticity theory, we study deformations that are approximately differentiable, orientation-preserving and one-to-one almost everywhere, and in addition have finite surface energy. This surface energy e{open} was used by the authors in a previous paper, and has connections with the theory of currents. In the present paper we prove that e{open} measures exactly the area of the surface created by the deformation. This is done through a proper definition of created surface, which is related to the set of discontinuity points of the inverse of the deformation. In doing so, we also obtain an SBV regularity result for the inverse. © 2011 Springer-Verlag.

Loeper G.,University Claude Bernard Lyon 1 | Loeper G.,University Pierre and Marie Curie
Archive for Rational Mechanics and Analysis | Year: 2011

Building on the results of Ma et al. (in Arch. Rational Mech. Anal. 177(2), 151-183 (2005)), and of the author Loeper (in Acta Math., to appear), we study two problems of optimal transportation on the sphere: the first corresponds to the cost function d2(x, y), where d(·, ·) is the Riemannian distance of the round sphere; the second corresponds to the cost function -log {pipe}x - y{pipe}, known as the reflector antenna problem. We show that in both cases, the cost-sectional curvature is uniformly positive, and establish the geometrical properties so that the results of Loeper (in Acta Math., to appear) and Ma et al. (in Arch. Rational Mech. Anal. 177(2), 151-183 (2005)) can apply: global smooth solutions exist for arbitrary smooth positive data and optimal maps are Hölder continuous under weak assumptions on the data. © 2010 Springer-Verlag.

Terry S.,French Institute of Health and Medical Research | Terry S.,University Pierre and Marie Curie | Beltran H.,New York Medical College
Frontiers in Oncology | Year: 2014

In normal prostate, neuroendocrine (NE) cells are rare and interspersed among the epithelium. These cells are believed to provide trophic signals to epithelial cell populations through the secretion of an abundance of neuropeptides that can diffuse to influence surrounding cells. In the setting of prostate cancer (PC), NE cells can also stimulate surrounding prostate adenocarcinoma cell growth, but in some cases adenocarcinoma cells themselves acquire NE characteristics. This epithelial plasticity is associated with decreased androgen receptor (AR) signaling and the accumulation of neuronal and stem cell characteristics. Transformation to an NE phenotype is one proposed mechanism of resistance to contemporary AR-targeted treatments, is associated with poor prognosis, and thought to represent up to 25% of lethal PCs. Importantly, the advent of high-throughput technologies has started to provide clues for understanding the complex molecular profiles of tumors exhibiting NE differentiation. Here, we discuss these recent advances, the multifaceted manner by which an NE-like state may arise during the different stages of disease progression, and the potential benefit of this knowledge for the management of patients with advanced PC. © 2014 Terry and Beltran.

Haq B.U.,National Science Foundation | Haq B.U.,University Pierre and Marie Curie
Global and Planetary Change | Year: 2014

Eustatic sea-level changes of the Cretaceous are reevaluated based on a synthesis of global stratigraphic data. A new terminology for local/regional or relative sea-level changes (eurybatic shifts) is proposed to distinguish them from global (eustatic) sea-level changes, with the observation that all measures of sea-level change in any given location are eurybatic, even when they include a strong global signal. Solid-earth factors that influence inherited regional topography and thus modify physical measures of amplitude of the sea-level rises and falls locally are reviewed. One of these factors, dynamic topography (surface expression of mass flow in the upper mantle on land- and seascapes), is considered most pertinent in altering local measures of amplitude of sea-level events on third-order time scales (0.5-3.0. Myr). Insights gained from these models have led to the reconciliation of variance between amplitude estimates of eurybatic shifts in any given region and global measures of eustatic changes. Global estimates of third-order events can only be guesstimated at best by averaging the eurybatic data from widely distributed time-synchronous events. Revised curves for both long-term and short-term sea-level variations are presented for the Cretaceous Period. The curve representing the long-term envelope shows that average sea levels throughout the Cretaceous remained higher than the present day mean sea level (75-250. m above PDMSL). Sea level reached a trough in mid Valanginian (~. 75. m above PDMSL), followed by two high points, the first in early Barremian (~. 160-170. m above PDMSL) and the second, the highest peak of the Cretaceous, in earliest Turonian (~. 240-250. m above PDMSL). The curve also displays two ~. 20. Myr-long periods of relatively high and stable sea levels (Aptian through early Albian and Coniacian through Campanian). The short-term curve identifies 58 third-order eustatic events in the Cretaceous, most have been documented in several basins, while a smaller number are included provisionally as eustatic, awaiting confirmation. The amplitude of sea-level falls varies from a minimum of ~. 20. m to a maximum of just over 100. m and the duration varies between 0.5 and 3. Myr. The causes for these relatively rapid, and at times large amplitude, sea-level falls in the Cretaceous remain unresolved, although based mainly on oxygen-isotopic data, the presence of transient ice cover on Antarctica as the driver remains in vogue as an explanation. This idea has, however, suffered a recent setback following the discovery of pristine foraminiferal tests in the Turonian of Tanzania whose oxygen-isotopic values show little variation, implying absence of glacioeustasy at least in the Turonian. The prevalence of 4th-order (~. 400. Kyr) cyclicity through most of the Cretaceous (and elsewhere in the Paleozoic, Jurassic and Cenozoic) implies that the periodicity on this time scale, presumably driven by long-term orbital eccentricity, may be a fundamental feature of depositional sequences throughout the Phanerozoic. © 2013.

Marks M.S.,University of Pennsylvania | Heijnen H.F.G.,Laboratory of Clinical Chemistry and Haematology | Raposo G.,University Pierre and Marie Curie | Raposo G.,French National Center for Scientific Research
Current Opinion in Cell Biology | Year: 2013

Lysosome-related organelles (LROs) comprise a group of cell type-specific subcellular compartments with unique composition, morphology and structure that share some features with endosomes and lysosomes and that function in varied processes such as pigmentation, hemostasis, lung plasticity and immunity. In recent years, studies of genetic diseases in which LRO functions are compromised have provided new insights into the mechanisms of LRO biogenesis and the regulated secretion of LRO contents. These insights have revealed previously unappreciated specialized endosomal sorting processes in all cell types, and are expanding our views of the plasticity of the endosomal and secretory systems in adapting to cell type-specific needs. © 2013 Elsevier Ltd.

Sweeney H.L.,University of Pennsylvania | Houdusse A.,University Pierre and Marie Curie
Cell | Year: 2010

Myosin VI is the only type of myosin motor known to move toward the minus ends of actin filaments. This reversal in the direction of its movement is in part a consequence of the repositioning of its lever arm. In addition, myosin VI has a number of other specialized structural and functional adaptations that optimize performance of its unique cellular roles. Given that other classes of myosins may share some of these features, understanding the design principles of myosin VI will help guide the study of the functions of myosins that adopt similar strategies. © 2010 Elsevier Inc.

Etoc F.,University Pierre and Marie Curie | Lisse D.,University of Osnabrück | Bellaiche Y.,University Pierre and Marie Curie | Piehler J.,University of Osnabrück | And 2 more authors.
Nature Nanotechnology | Year: 2013

Many cell functions rely on the coordinated activity of signalling pathways at a subcellular scale. However, there are few tools capable of probing and perturbing signalling networks with a spatial resolution matching the intracellular dimensions of their activity patterns. Here we present a generic magnetogenetic approach based on the self-assembly of signalling complexes on the surface of functionalized magnetic nanoparticles inside living cells. The nanoparticles act as nanoscopic hot spots that can be displaced by magnetic forces and trigger signal transduction pathways that bring about a cell response. We applied this strategy to Rho-GTPases, a set of molecular switches known to regulate cell morphology via complex spatiotemporal patterns of activity. We demonstrate that the nanoparticle-mediated activation of signalling pathways leads to local remodelling of the actin cytoskeleton and to morphological changes. © 2013 Macmillan Publishers Limited. All rights reserved.

French Institute of Health, Medical Research, French National Center for Scientific Research, University of Rennes 1, University Paris Diderot, University Pierre and Marie Curie | Date: 2011-04-04

A method for treating and/or ameliorating and/or preventing a disease or a disorder, the method comprising administering to an individual in need thereof at least one nitrogen heterocycle derivative of formula (I): The at least one nitrogen heterocycle derivative may also be used as a proteasome activity modulator in the manufacture of a pharmaceutical composition intended to prevent and/or treat a disease condition mediated by the proteasome activity.

French National Center for Scientific Research, French Institute of Petroleum, University Pierre and Marie Curie | Date: 2011-12-15

A process is described for the preparation of an inorganic material with a hierarchical porosity in the micropore and mesopore domains. The material has at least two elementary spherical particles having a maximum diameter of 200 microns. The process comprises:

Solvay Group, French National Center for Scientific Research, University Pierre, Marie Curie and University Claude Bernard Lyon 1 | Date: 2012-12-18

Process for the preparation of a vinylidene chloride polymer comprising polymerizing vinylidene chloride and optionally at least one ethylenically unsaturated monomer copolymerizable therewith under the control of a RAFT agent of formula (II).

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-12-2015 | Award Amount: 2.00M | Year: 2016

The Internet-of-Things (IoT) is rapidly heading for large scale meaning that all mechanisms and features for the future IoT need to be especially designed and duly tested/certified for large-scale conditions. Also, Security, Privacy and Trust are critical elements of the IoT where inadequacy of these is a barrier to the deployment of IoT systems and to broad adoption of IoT technologies. Suitable duly tested solutions are then needed to cope with security, privacy and safety in the large scale IoT. Interestingly, world-class European research on IoT Security & Trust exists in European companies (especially SME) and academia where even there are available technologies that were proven to work adequately in the lab and/or small-scale pilots. More, unique experimental IoT facilities exist in the EU FIRE initiative that make possible large-scale experimentally-driven research but that are not well equipped to support IoT Security & Trust experiments. But notably, Europe is a leader in IoT Security & Trust testing solutions (e.g. RASEN toolbox, ETSI Security TC, etc.) that can be extended to large-scale testing environments and be integrated in FIRE IoT testbeds for supporting experimentations. The ARMOUR project is aimed at providing duly tested, benchmarked and certified Security & Trust technological solutions for large-scale IoT using upgraded FIRE large-scale IoT/Cloud testbeds properly-equipped for Security & Trust experimentations. To this, ARMOUR will: (1) Enhance two outstanding FIRE testbeds (> 2700nodes; ~500users) with the ARMOUR experimentation toolbox for enabling large-scale IoT Security & Trust experiments; (2) Deliver six properly experimented, suitably validated and duly benchmarked methods and technologies for enabling Security & Trust in the large-scale IoT; and (3) Define a framework to support the design of Secure & Trusted IoT applications as well as establishing a certification scheme for setting confidence on Security & Trust IoT solutions.

Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: PEOPLE-2007-1-1-ITN | Award Amount: 3.22M | Year: 2008

There has been an increasing realization over the last 30 years that to preserve water quality and quantity in Europe, measures at both European and national levels are needed. Our groundwater resources are at risk from a wide variety of stresses including point and diffuse sources of contamination, over-abstraction and saline intrusion. Minimizing this risk requires a good understanding of the physical, chemical and biological processes involved and the development of tools to assess groundwater vulnerability, aid water management and design protection strategies. To meet the challenges imposed by the new EU Water and Ground Water Framework Directives, the water industry throughout Europe is already significantly expanding, creating an increasing demand for appropriately educated graduates. The proposed ITN network, IMVUL, is aimed at training researchers in the major issues and processes relevant to groundwater vulnerability. The network consists of 8 partners in the United Kingdom, France, Spain, Italy, Israel and Norway and 13 associated partners from the water industry. The research objectives are to increase our understanding of the fundamental processes relevant to groundwater vulnerability and develop improved prediction tools that can contribute to the protection and sustainable use of Europes groundwater resources. This will be achieved through investigations of case study aquifers and their vulnerability issues, laboratory experiments of contaminant transport in the subsurface, and numerical and analytical modelling of the processes pertinent to groundwater vulnerability. The proposed network will contribute to satisfying a growing skill demand in groundwater research and the water industry by producing graduates with not only a sound knowledge of the scientific basis of groundwater vulnerability, but also good investigatory skills through their research experience and additional training relevant to the water industry.

French National Center for Scientific Research, University Paris Est Creteil, University Pierre, Marie Curie, Icm Institute Du Cerveau Et Of Moelle Epiniere, Otr3 and Assistance Publique Hopitaux Paris | Date: 2012-10-15

The present invention relates to a method of diagnosis, prognostic or treatment of neurodegenerative diseases, in particular Alzheimers disease.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2010.2.4.2-3 | Award Amount: 15.68M | Year: 2010

The initiation and perpetuation of atrial fibrillation (AF) can be regarded as a complication of a progressive transformation of the structure and functional properties of the atria. This transformation is the result of complex and multiple changes at the molecular, cellular and organ levels which interact to form the basis for proarrhythmic mechanisms in AF. Numerous individual and environmental factors are probably involved in this profound transformation process in the atria. Therefore, we believe that progress in the diagnostics, prevention and treatment of AF requires highly integrative research from the molecule to bedside and from specific signaling pathways and electrophysiological mechanisms to population based studies. A consortium was formed providing this variety of expertises and has identified central research objectives for improvements in AF prevention and therapy. In 5 work packages focusing on basic research, new biomarkers for AF and therapeutic targets will be identified. We will study mechanisms of conduction disturbances in the atria, explore new ion channel targets for treatment of AF, identify specific alterations in the atria depending on the underlying heart disease, and evaluate beneficial effects of organ-protective compounds. Within two clinically oriented work packages the clinical application of these findings will be tested. The predictive value of diagnostic tools like serum biomarkers, 3D reconstruction of atrial conduction patterns based on high resolution body surface ECGs, and echocardiographic markers will be studied in large scale population studies. The new therapeutic targets will be explored in smaller prove-of-principle clinical trials (substrate oriented ablation, new pharmacological targets, and local gene delivery).

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.2.1 | Award Amount: 4.26M | Year: 2013

SPENCER will break new ground for cognitive systems in populated environments. While there is an increasing focus on making robots more socially aware, related approaches are still limited in their capacity to perceive, model and learn human social behavior and respond with appropriate actions in real-time from mobile platforms. SPENCER will systematically address these problems and advance the fields of perception of individual humans and groups, normative human behavior learning and modeling, socially-aware mapping, and socially-aware task, motion and interaction planning under real-world conditions. In particular, by addressing these problems simultaneously in a multi-disciplinary project team, we will exploit synergies which will enable us to design cognitive systems that reach new levels of autonomy, efficiency, robustness, and safety in populated environments, optimizing the trade-off between objective and subjective performance measures. The project is motivated by an end-user market-pull and a technology-push. End-users seek innovative solutions to guide people and efficient mobile information provision. Robotics research meanwhile, has become suitably advanced to start considering humans as more than objects but as people with relationships, social rules and culturally diverse backgrounds. To this end, SPENCER will combine robotics research with social signal processing and socio-psychological user studies that will guide the learning process of socially normative robot behaviors into the relevant directions. The SPENCER consortium includes a large European airline as end-user that will deploy the SPENCER robotic demonstrator for the purpose of smart flow management of transfer passengers at the Amsterdam Schiphol Airport. This deployment has a large exploitation potential and is an excellent benchmark of the research developed in SPENCER given the demanding nature of airports as highly populated real-world environments.

Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: INFRA-2011-3.2. | Award Amount: 1.27M | Year: 2011

The objective of this project is to strengthen the links and integration of the Euro-Argo European research infrastructure into the Argo International strategy of global ocean observations, and to seek participation by, and to develop cooperation with, potential participants in the European neighbouring areas which have a maritime interest. The following activities are planned: - Work on the evolution of the Argo core mission together with international partners (O2, bio-geochemical sensors, deep floats, extension to polar and marginal seas), - Work on the evolution of the Argo data centers (Delayed Mode Quality Control of the North Atlantic ARC and Southern Ocean Argo Regional Center) and role of the European components, - Refine the float deployment strategy in Europe and international seas and links with international partners, - making the interfaces with JCOMMOPS and Argo information center (AIC), - working on legal aspects and policy issues (law of the sea), - Organize scientific and thematic (regional) workshops open to international partners This project will be carried by the Euro-Argo preparatory phase project partners that will form the future partners of the Euro-Argo ERIC.

Agency: Cordis | Branch: H2020 | Program: ERC-ADG | Phase: ERC-ADG-2014 | Award Amount: 2.40M | Year: 2016

Cryptology is a foundation of information security in the digital world. Todays internet is protected by a form of cryptography based on complexity theoretic hardness assumptions. Ideally, they should be strong to ensure security and versatile to offer a wide range of functionalities and allow efficient implementations. However, these assumptions are largely untested and internet security could be built on sand. The main ambition of Almacrypt is to remedy this issue by challenging the assumptions through an advanced algorithmic analysis. In particular, this proposal questions the two pillars of public-key encryption: factoring and discrete logarithms. Recently, the PI contributed to show that in some cases, the discrete logarithm problem is considerably weaker than previously assumed. A main objective is to ponder the security of other cases of the discrete logarithm problem, including elliptic curves, and of factoring. We will study the generalization of the recent techniques and search for new algorithmic options with comparable or better efficiency. We will also study hardness assumptions based on codes and subset-sum, two candidates for post-quantum cryptography. We will consider the applicability of recent algorithmic and mathematical techniques to the resolution of the corresponding putative hard problems, refine the analysis of the algorithms and design new algorithm tools. Cryptology is not limited to the above assumptions: other hard problems have been proposed to aim at post-quantum security and/or to offer extra functionalities. Should the security of these other assumptions become critical, they would be added to Almacrypts scope. They could also serve to demonstrate other applications of our algorithmic progress. In addition to its scientific goal, Almacrypt also aims at seeding a strengthened research community dedicated to algorithmic and mathematical cryptology.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: ENV.2007. | Award Amount: 12.95M | Year: 2008

THOR will establish an operational system that will monitor and forecast the development of the North Atlantic THC on decadal time scales and access its stability and the risk of a breakdown in a changing climate. Together with pre-existing data sets, ongoing observations within the project will allow precise quantitative monitoring of the Atlantic THC and its sources. This will, for the first time, allow an assessment of the strength of the Atlantic THC and its sources in a consistent manner and will provide early identification of any systematic changes in the THC that might occur. Analysis of palaeo observations covering the last millennium and millennium time scale experiments with coupled climate models will be carried out to identify the relevant key processes and feedback mechanisms between ocean, atmosphere, and cryosphere. In THOR, the combined effect of various global warming scenarios and melting of the Greenland ice sheet will also be thoroughly assessed in a coupled climate model. Through these studies and through the assimilation of systematic oceanic observations at key locations into ocean circulation models, THOR will forecast the development of the Atlantic THC and its variability until 2025, using global coupled ocean-atmosphere models. THOR will also assess induced climate implications of changes in the THC and the probability of extreme climate events with special emphasis on the European/North Atlantic region. THOR builds upon techniques, methods and models developed during several projects funded within FP5 and FP6 as well as many nationally funded projects. The project will contribute to Global Monitoring for Environment and Security (GMES), to Global Observing Systems such as to the Global Ocean Observing system (GOOS), and to the International Polar Year (IPY).

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2007.8.0 | Award Amount: 3.01M | Year: 2009

Ever since the insightful suggestion of John von Neumann, self-reproducing automata are considered to be a main long-term goal of IT. Biologists are dealing with such systems that arose in the course of evolution by natural selection. The future realization of technological artefacts that will mimic, or be inspired by biological automata, will face many problems that biological evolution had to solve. e-Flux will develop droplet-based digital microfluidic systems for the manipulation of reproducing artificial compartments and natural cells (including the analysis of adaptive pathways and molecular cooperation). The project combines cutting-edge technological development with high-level theoretical analysis of the experimentally realized systems. By the application of a large population of electronically controlled microdroplets we shall select for RNA replicator-based molecular networks that can learn from experience. The same method will be used to reconstruct a hypothetical interim stage of early biological evolution where protocells harboured a bag of competing catalytically active RNA genes. These achievements need technological development of our microfluidic machinery. As an example of unconventional biotechnology, we will put bacteria into the droplets, and select for various traits in a novel kind of evolution machine. Theoretical analyses will complement the experimental work, especially in order to develop a better understanding of evolvability (the genetically controlled capacity to respond to directional selection) in artificial and natural molecular systems.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: ENV.2010.3.1.8-1 | Award Amount: 3.50M | Year: 2011

In the context of climate change mitigation, technologies for removing the CO2 from the atmosphere are key challenges. The transfer of carbon from the atmosphere into useful carbon deposits is currently one promising option.Transferring biomass to carbon-rich materials with potential mega-scale application is an option to sequester carbon from plant material, taking it out of the short-term carbon cycle and therefore binding CO2 efficiently and even in a useful, productive, way into longer term non-atmospheric carbon pools. EuroChar will investigate carbon sequestration potentials that can be achieved by transforming plant biomass into charcoal (or Biochar) and add that to agricultural soils. Biochar production will be demonstrated using thermochemical (TC) or hydrothermal carbonization processes (HTC) that can produce energy and store 15 to 20% of the Carbon originally contained in the biomass. Detailed ISO-accredited whole Life Cycle Assessment will be carried out according to the International Reference Life Cycle Data System (ILCD) Handbook on LCA, for both TC and HTC production systems to evaluate the net Carbon sequestration capacity associated to Biochar production. Physico-chemical properties of Biochar will be analysed in a series of laboratory studies that will use standardized analytical protocols, and a specific phyto-toxicity test will be made using molecular approaches involving a model plant. Part of the study will also address the short versus long-term stability of Biochar using recently produced and aged charcoal samples coming from archaeological sites. Specific investigations will also be made to assess Biochar decomposition using CO2-efflux measurements from 13C labelled Biochar. Three large-scale field experiments will be made in Italy, France and UK to analyse realistic scale application of Biochar. Upscaling will be considered by scenario analyses that will both consider the potential C-sequestration actually achievable at the european scale and the climate warming balance associated to carbon sequestration and potential changes in the mean surface albedo, due to massive use of Biochar as soil amendant. A number of stakeholders will be involved to review projects activities. For this the EuroChar Stakeholder Committee will be created and met periodically during annual project meetings. Dissemination activities will be implemented to make projects results available to a wider audience and the media.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.7.2 | Award Amount: 3.39M | Year: 2010

More than 2,6 million people in Europe have problems with their upper limbs and therefore many of them depend on Assistive Technologies (AT). As the potential of the individual user is very specific, adaptive, ICT-based solutions are needed to let this population group participate in modern society. Such solutions are rarely available on todays market.AsTeRICS will provide a flexible and affordable construction set for realising user driven AT by combining emerging sensor techniques like Brain-Computer Interfaces and computer vision with basic actuators. People with reduced motor capabilities will get a flexible and adaptable technology at hand which enables them to access the Human-Machine-Interfaces (HMI) at the standard desktop but in particular also of embedded systems like mobile phones or smart home devices.AsTeRICS will implement a set of building blocks for the realisation of AT:\tSensors which allow the individual to exploit any controllable body or mind activity for interacting with HMI\tActuators for interfacing to standard IT, to embedded systems and to interact with the environment\tAn Embedded Computing Platform that can be configured to combine sensors and actuators to tailored AT-solutions which support the full potential of an individual userThe core of the software suite will be provided as Open Source. The complete system will be affordable for many people who cannot benefit from leading edge supportive tools today.AsTeRICS revolutionises the concept of AT: AT today mostly focuses on a certain task or situation. Due to the growing importance of the PC, AT has been oriented towards standard Human-Computer (HCI) or desktop interfaces. AsTeRICS respects the strong need for flexible, adaptable AT functionalities accompanying people with disabilities away from the desktop, enabling them to interact with a divers and fast changing set of deeply embedded devices in our modern environment.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: AAT.2010.1.1-2.;AAT.2010.6.2-1. | Award Amount: 6.54M | Year: 2011

ATLLAS II is a logical follow-up of a recently finalized FP6 project which has as objectives the identification and assessment of advanced light-weight and high-temperature resistant materials for high-speed vehicles up to Mach 6. The material requirements are first defined through an in-depth feasibility study of a Mach 5-6 vehicle. The consortium has now this capability at hand as they can rely on a first set of validated tools, material databases and valuable experience acquired during ATLLAS-I. Starting with a preliminary aero-thermal-structural high-speed vehicle design process, further multi-disciplinary optimization and testing will follow to result into a detailed layout of an independently European defined and assessed high-speed vehicle. Special attention will be given to alleviate sonic boom and emissions at high altitudes. Throughout the design process, the aero-thermal loads will define the requirements for the proposed materials and cooling techniques needed for both the airframe and propulsion components. The former will focus on sharp leading edges, intakes and skin materials each coping with different external aero-thermal loads. The latter will be exposed to internal combustion driven loads. Both metallic (Titanium Matrix Composites and Ni-based Hollow Sphere Stackings) and non-metallic materials (Ceramic Matrix Composites and Ultra High Temperature Composites) will be evaluated. Combined aero-thermal-structural experiments will test various materials as specimens and realistic shapes at extreme conditions representative for high flight Mach numbers. Both static and cyclic tests at low and high temperatures are planned including the evaluation of their durability in terms of long duration exposure to the harsh flight conditions. The materials assigned to dedicated engine components will be exposed to realistic combustion environments. These will be combined with passive or active cooling technologies developed in ATLLAS-I.

Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.78M | Year: 2011

Symbiosis research is currently in the midst of a revolution as molecular techniques are leading to major breakthroughs in our understanding of interactions between animals and microbes. There is an emerging recognition that all animals are intimately associated with a complex community of beneficial microbes that are essential for their development, nutrition, and health. Thus, modern symbiosis research has become a newly emerging supra-disciplinary field with novel and innovative methods for examining microbial symbionts, the vast majority of which remain as yet uncultivable. As so often when novel technologies open up new areas of research, training for students lags behind. We propose to close this gap by offering a comprehensive and innovative training in the microbial ecology and evolution of animal symbionts. The proposed ITN Symbiomics will include 14 leading research groups as well as 4 top-tier participants from the private sector to provide 14 early stage researchers (ESRs) and 1 experienced research (ER) with an interdisciplinary and synergistic training. Cutting edge methods in molecular biology and image analysis will be used to analyze a broad range of hosts from protozoan and invertebrate animal groups. Symbiomics will provide training through a combination of local and network-wide activities that will include research, secondments, workshops and courses including soft skills training, networking and meetings, regular thesis committee meetings, and mentoring. By pooling the scientific, technological, and entrepreneurial expertise of the Symbiomics partners, this ITN will provide a synergistic research environment and training that extends far beyond what each partner would be able to offer with local training alone. At the end of their training, the early stage researchers will have the skills they need for successful careers in academia and industry in a broad range of disciplines in the fields of environmental, applied, and medical microbiology.

Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: NMP-2008-2.6-3 | Award Amount: 1.14M | Year: 2009

A key thrust of FP7 is to promote international collaborative research with third countries. The EULASUR project will address the Call for Co-ordination Action in Materials by creating a cooperation platform for forming strategic research partnerships between scientists, policy makers, technology transfer and industrial experts in the EC and 3 Latin-American countries belonging to MERCOSUR: Brazil, Uruguay and Argentina (BRAU). Research topics will be identified within the fields of i) advanced functional ceramics and ii) hybrid materials and nanomaterials where significant opportunities exist for mutually beneficial actions between the two regions. The goals are designed to gain first hand knowledge of the state of the art research in these fields through summer schools, exchanges and partnership actions. The project will also address the social, political and cultural factors impacting technology transfer and collaboration between the EU and BRAU countries. The core activities of EULASUR are based on some research Groups of Excellence that already cooperate bilaterally and will integrate them with additional groups to generate a stable, integrated scientific platform of international excellence interested to collaborate in the development of materials research in specific topics of interest to both regions. The EULASUR partnership is composed of 15 research centres, 8 from Europe and 7 from BRAU countries selected on the basis of: excellence in research, complementary skills and access to national and international R&D policy makers. Government representatives will participate in the EULASUR Advisory Board. Industrial companies and technological centres are expected to take part in the project activities. EULASUR has 5 WPs. 3 designed to build contacts and identify opportunities, 1 to disseminate results to key stakeholders and policy makers and 1 management and progress measures. Each WP has two WP Leaders: one from BRAU and the other from the EU.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: AAT.2012.3.3-2. | Award Amount: 6.28M | Year: 2012

The UFO project aims at ensuring aviation safety at current high standards or even better, regardless of air transport growth, through Wake-Vortex Advisory Systems improvement, in connection with SESAR P12.2.2 project. UFO research works will address a wide range of innovative technologies through studies of new Ultra Fast Lidar/Radar Wind & EDR (Eddy Dissipation Rate for turbulence) monitoring sensors, usable for Wake-Vortex Hazards Mitigation, but also for severe Cross-Wind, Air Turbulence and Wind-Shear. Constrained by high update rate and accuracy requirements needed for wind measurements, 2D electronic scanning antenna technology based on low cost tile will be explored for X-band radar through a development of a tile mock up as well as a new high power laser source of 1.5 micron Lidar 3D scanner with higher power. In addition, new design tools will be developed through simulators, able to couple Atmosphere models with Electromagnetic, Radar and LIDAR models. In parallel, advanced Doppler signal processing algorithm will be developed and tested for 3D wind field and EDR monitoring, including the algorithm for the resources management of the different sensors. Comparison with already existing sensors as C band meteorological radar and S band ATC radar, but also ADS-B Downlink will be studied. Calibration of the ground sensors (Lidar, X band radar, C band radar with ADS-B datalink) and the simulators will be achieved through a set of experimental trials in Munich and Toulouse. In Toulouse, an aircraft equipped with airborne probes will enable in situ comparison. Coordination with SESAR, through Eurocontrol, as associated partner, airports as End user in the UFO steering committee, will be favoured. The team is composed of the main experts in Europe of the domain: 2 large companies (TSA, TR6), 4 universities (UCL, TUBS, TUD, UPMC), 1 SME (Leosphere), 3 governmental research labs (DLR, ONERA, NLR) and 2 MET Offices (DWD, KNMI).

Agency: Cordis | Branch: FP7 | Program: CP | Phase: INFRA-2011-2.1.1. | Award Amount: 4.94M | Year: 2011

Underwater gliders are intelligent and affordable platforms, useful for long-term, multi parameter marine observations. Because of their remotely controlled navigational capabilities and the high spatial and temporal resolution of their measurements in real-time, gliders have been identified to fill gaps existing in the existing ocean observing systems. Along with there rapidly growing importance in purely science driven applications, the implementation of gliders into the Global Ocean Observing System has been recognized as a key point to improve the observational capabilities of the observing systems. The objective of the GROOM proposal is the design of a new European research infrastructure to use underwater gliders for the benefit of European citizens, researcher, and industry. GROOM will define the scientific, technological and organizational/legal levels, of a European glider capacity for research and sustained observations of the oceans, in line with the other European and international initiatives for marine in-situ observations. The proposal for this new infrastructure strongly relies on EuroARGO and JERICO infrastructures which are emerging and also considers the relevant international coordinating bodies such as GOOS. The proposed technological infrastructures will be based on several dedicated gliderports to maintain and operate a European fleet of gliders in coordination with US, Canadian, Australian and other similar infrastructures. This new infrastructure would be beneficial for both academic oceanographic research and operational oceanography systems on which a large number of marine activities and societal applications now rely.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2012.2.4.4-2 | Award Amount: 3.85M | Year: 2012

Children with diffuse lung disease, also called childhood interstitial lung diseases (chILD), may have one of more than 200 entities, the biggest group of respiratory orphan lung diseases. Frequently undiagnosed because of lack of awareness or complex differential diagnosis, they lead to much morbidity, mortality (about 15%) and psychosocial stress for the families. Current lack of evidence based guidelines reflects the absence of any real scientific evidence for management. All current therapeutic options are off label. We propose that leading European clinical scientists and paediatric pulmonologists collaborate to assemble cohorts in which children with well defined disease entities, verified by international panels of clinicians, radiologists, geneticists and pathologists are followed in a pan-European database and biobank compatible with others worldwide to allow common projects. Outcomes and treatment schemes will be rigorously defined and their value systematically assessed. We will put defined treatment protocols systematically into practice to allow their evaluation and perform a randomised controlled trial in line with the EU recommendations, to put prescribing for children on an evidence based footing. This will give evidence to use medicines available based on their objectively determined effects and side effects. The project will lead to accepted evidence-based and consensus-agreed diagnostic and management clinical guidelines, to a better care of patients afflicted by rare chILD and lead to improved quality of life for children with these incurable diseases.

Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-ITN-2008 | Award Amount: 3.72M | Year: 2009

Aims: provide a cutting edge research training programme encompassing complementary approaches to the investigation of liver and pancreatic development and disease. Provide early stage researchers with a balanced mix of experience and skills in academic and industry based research. Give early stage researchers a set of transferrable skills which will improve their employment and career prospects. Objectives: 1) To provide a broad multi-disciplinary approach to liver and pancreatic development and disease which will ensure a solid foundation in research technology and methods. 2) To offer a number of multi-centre and cross-sector projects. 3) To organize regular meetings which will provide task-specific and complementary training in skills essential for career development. Implementation: 1) involvement of highly successful research leaders and groups (with expertise in different disciplines including systems biology and bioinformatics, developmental biology, genomics, genetics and epigenetics, cell biology, engineering and drug development) in design and running of this programme will ensure the cutting edge research methodology and multidisciplinary approach to training. 2) Each research project will involve minimum two partners. 3) Partners will alternate in organizing network meetings which will include laboratory courses, single-topic conferences and network workshops. 4) The experienced researchers recruited to the network will spend more time in the industrial setting and have more leadership training and responsibilities.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2007.8.0 | Award Amount: 4.58M | Year: 2008

HIDEAS aims at a breakthrough in the information capacity of Quantum Communication (QC), well beyond the standard single-mode approach, by exploiting the intrinsic multi-modal and multivariate character of the radiation field. Our long term vision is that of a broadband Quantum Communication, where all the physical properties of the photons are utilized to store information. Working at the quantum level requires: i) to produce quantum entanglement of light in high dimensional and multivariate spaces and ii) to create multimode quantum interfaces between light and matter in order to store high-D quantum states of light in long-lived matter degrees of freedom. Beneficial impacts will be also on Quantum Metrology. As crucial steps towards these objectives we propose five research lines: WP1 aims at bringing to the quantum realm the spectacular progress achieved by the introduction of frequency combs in the classical domain. WP2 aims at realizing sources of multimode spatially entangled light appropriate for paving the way to parallel quantum communication and information processing. WP3 aims at realizing a very high-D entanglement between twin photons produced by parametric down- conversion (PDC). It focuses on the conjugate variables angle and optical angular momentum (OAM), providing a larger alphabet for QC and a more robust non-locality. WP4 explores the non-factorable spatio-temporal X-structure of light entanglement in PDC, opening an avenue that offers unique access to the full broad band of PDC. WP5 exploits various forms of multimode light-matter entanglement, to realize multi-modal light-atom quantum interfaces and a parallel quantum memory for light (quantum hologram), with resolution and memory capacity exceeding those of classical holograms. The consortium gathers an unparalleled expertise in measuring and manipulating OAM, in generating/controlling quantum effects in multi-mode PDC and in realizing light-matter quantum interfaces.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.2.1 | Award Amount: 9.58M | Year: 2010

The scientific goals of the proposal revolve around the reciprocal linkages between the physical hand and its high-level control functions, and about the way that the embodiment enables and determines its behaviours and cognitive functions. THE Hand Embodied refers to the hand as both a cognitive entity standing for the sense of active touch and as the physical embodiment of such sense, the organ, comprised of actuators and sensors that ultimately realize the link between perception and action. The study of the intrinsic relationship between the hand as a cognitive abstraction and its bodily instance will be made possible by: (a) performing neuroscientific and perceptual behavioural studies with participants engaged in controlled manual activities; and (b) the parallel development of a theoretical framework to lay the foundations for design and control of robotic hands and haptic interfaces. The general idea is to study how the embodied characteristics of the human hand and its sensors, the sensorimotor transformations, and the very constraints they impose, affect and determine the learning and control strategies we use for such fundamental cognitive functions as exploring, grasping and manipulating. The ultimate goal of the present proposal is to learn from human data and hypotheses-driven simulations how to devise improved system architectures for the hand as a cognitive organ, and eventually how to better design and control robot hands and haptic interfaces. The project hinges about the conceptual structure and the geometry of such enabling constraints, or synergies: correlations in redundant hand mobility (motor synergies), correlations in redundant cutaneous and kinaesthetic receptors readings (multi-cue integration), and overall sensorimotor system synergies. These are also our key ideas for advancing the state of the art in artificial systems for robotic manipulation and haptic and neuroprosthetic interfaces.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.10.1.4 | Award Amount: 1.47M | Year: 2011

The goal of the SecFuNet project is to design and develop a coherent security architecture for virtual networks and cloud accesses. The proposed architecture will provide solutions allowing the management of the security of communications for all machines connected to a public cloud using virtual networks. Hence, we need a coherent and robust identification scheme as well as a strong authentication system. Algorithms robust to intrusions are also needed for creating a secure environment. Besides, the proposed architecture must guarantee security in the virtualized infrastructure, through isolation of virtual networks and access control for users and managers. The identification of authorized users, however, must not compromise their privacy. Moreover, it is necessary to bring an ergonomic security scheme that is acceptable for all users, even those unknowledgeable in computer science. And finally, the proposed scheme must take into account the heterogeneity of equipment (wireless and wired) to preserve interoperability.\nThis European-Brazil project is based on a 381 person-month and the total budget for European partners is 1,470,076 for EU contribution of 1,099,350 for Europe and a contribution from Brazil of 2,470,876 R$.

Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.90M | Year: 2016

The proposed project is built on the successful training and research experience of the leading European research groups working in the field of cavity optomechanics. Our ENT unites a total of 14 leading groups in the field, of which two are major industrial players that utilize MEMS and NEMS - Bosch and IBM. The main goal of the project is to exploit optomechanical interactions in views of novel functionality and possible applications of cavity optomechanical systems that were envisioned by consortium partners during their previous research activities. The possible applications include for instance MEMS sensors based on two-dimensional materials like graphene, quantum limited microwave amplifiers, and low noise optical to microwave frequency photon converters. While the majority of the experiments will firmly reside in the realm of classical, albeit weak, signals or fields, the aspired performance will also allow exploiting schemes in scenarios where quantum nature of the signal is relevant.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: NMP.2012.2.1-2 | Award Amount: 3.51M | Year: 2013

CEOPS project will focus on a sustainable approach for the production of methanol from CO2, which is a precursor for fine chemicals products. The approach will reinforce the link between large CO2 emitters and fine chemical industries at the European level. The concept relies on two chemical pathways, CO2 to CH4 and CH4 to CH3OH with the intermediate carbon vector: methane. Methane benefits from the extended and existing natural gas network infrastructure. Its distribution will prevent additional CO2 emissions (rail & road transportation). This approach will favour the emergence of small and flexible production units of fine chemicals from methanol. The technological work is based on advanced catalysts and electro-catalytic processes. CEOPS will develop advanced catalysts for application in three promising electro-catalytic processes (Dielectric barrier discharge plasma catalysis, Photo-activated catalysis and Electro-catalytic reduction) to increase their efficiency overtime for both pathways. The performances of the studied catalyst and process schemes will be benchmarked and the most efficient one, for each pathway, will be selected for a prototype. This prototype will be realised at a scale of 3m3.h-1 of methane, it will validate the concept and generate the required data for the techno-economic assessment. The consortium merges the skills of 2 research organisations, 3 universities, 1 SME, 1 non profit organisation, 2 industries and 1 cluster. The project is led by CEA-LITEN. Italcementi, GSER and CCB will bring respectively their expertise in CO2 emissions, CH4 injection and transportation and on methanol use for the fine chemical industry. They also contribute to the techno-economic and environmental assessments. IST, IREC, OMNIDEA will develop advanced catalysts. UPMC, CEA, IREC, NOVA will develop electro-catalytic processes. CEA assisted by the consortium will implement the prototype. EMSR and CCB will ensure the dissemination of the CEOPS concept and results.

Agency: Cordis | Branch: FP7 | Program: ERC-SG | Phase: ERC-SG-SH2 | Award Amount: 1.37M | Year: 2009

The development of geophysics of the last century has become more relevant to contemporary research. This is because much of the data accumulated in the past have allowed mapping many features of the Earth. Thanks to this information scientists can now appreciate long term changes in climate and environment. However, the data now available were not put together for this purpose. A big leap forward in geophysics materialised during the Cold War, when civilian and military research agencies promoted its expansion in developed countries. Actually, it was the confrontation between Superpowers that boosted the discipline. Some of its branches developed because of the search for oil and uranium in the emerging nuclear arms race. New techniques of geophysical surveying became known especially because of the requirements of nuclear warfare. Western European research groups were deeply involved in geophysical research because US funding organisations (partly through the North Atlantic Treaty Organization, NATO) encouraged international collaboration. US/European collaborative programmes covertly aimed at gathering data and techniques and they paralleled US and European intelligence operations. This project aims at revealing how the geosciences developed during the Cold War, looking at the network of institutions that promoted a new understanding of the Earth, and the motives in play in expanding geophysical studies. It will focus on scientific and intelligence programmes to find out how they complemented each other. The impact of the proposed research is far reaching promoting new scholarly approaches based on team-based analysis; cross-examination of empirical evidence; and international cooperative work. TEUS will be greatly beneficial to the expansion of the recent history of science and technology. And it will also have an impact on current security studies by shedding new light on the relationship between the geosciences and intelligence organisations.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: AAT.2010.1.1-3. | Award Amount: 7.27M | Year: 2010

FIRST will deliver key enabling technologies for combustion emission reduction by developing improved design tools and techniques for modelling and controlling fuel sprays and soot. Aviations environmental impact must be reduced to allow sustainable growth to benefit European industry and society. This is captured in ACAREs 2020 goals of reducing CO2 by 50%, NOx by 80% and in SRA1/2 proposed reductions in soot and development of alternative fuels. CFD tools are essential to design combustors for emissions, soot, thermo-acoustic noise, flame stability, cooling and the outlet temperature profile. The two most significant gaps in todays CFD capability are fuel injector spray and soot modelling. The fuel injector is critical to the design of low emission combustors. By understanding and controlling the complex physics of fuel atomisation and mixing, the emissions performance can be directly improved. CFD simulations have for many years relied upon over-simplistic definition of the fuel spray. The availability of methods developed in the automotive industry and faster computers make their application to aero-engines timely. The FIRST project will deliver a step change in the detail and accuracy of the fuel spray boundary conditions; through novel physics based modelling techniques, advanced diagnostic measurements and the derivation of sophisticated correlations. CFD computations of the combustion system also provide the information needed to allow soot emissions to be controlled and minimised. These calculations require the improved fuel spray boundary condition described but also need higher fidelity physical and chemical models describing the soot production and consumption processes. FIRST will deliver improved CFD soot models, enabling the reduction of soot in aero-engine combustors. The design of future alternative fuels will be enhanced by FIRST by performing predictions and measurements of both fuel sprays and soot across a number of alternative fuels.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2013.6.1-2 | Award Amount: 11.51M | Year: 2013

Massive economic and population growth and urbanisation are expected to lead to a tripling of anthropogenic emissions in southern West Africa (SWA) between 2000 and 2030, the impacts of which on human health, ecosystems, food security and the regional climate are largely unknown. An assessment of these impacts is complicated by (a) a superposition with effects of global climate change, (b) the strong dependence of SWA on the sensitive West African monsoon, (c) incomplete scientific understanding of interactions between emissions, clouds, radiation, precipitation and regional circulations and (d) by a lack of observations to advance our understanding and improve predictions. The DACCIWA project will conduct extensive fieldwork in SWA to collect high-quality observations, spanning the entire process chain from surface-based natural and anthropogenic emissions to impacts on health, ecosystems and climate. Combining the resulting benchmark dataset with a wide range of modelling activities will allow (a) to assess all relevant physical and chemical processes, (b) to improve the monitoring of climate and compositional parameters from space and (c) to develop the next generation of weather and climate models capable of representing coupled cloud-aerosol interactions, which will ultimately lead to reduced uncertainties in climate predictions. SWA with its rich mix of emissions and diverse clouds is ideal for such a study and many findings and technical developments will be applicable to other monsoon regions. Using a targeted dissemination strategy, DACCIWA will deliver a comprehensive scientific assessment and actively guide sustainable future planning and policy-making for West Africa and beyond. The interdisciplinary and experienced DACCIWA team will build on the scientific and logistical foundations established by AMMA (EU FP6) and collaborate closely with operational centres, international programs (e.g. WCRP, IGBP), policy-makers and users to maximise impact.

French Institute of Petroleum, University Pierre, Marie Curie and French National Center for Scientific Research | Date: 2011-05-06

The method for catalytic conversion of alcohols according to the present invention using a zinc oxide catalyst comprises a thermal pretreatment stage in an inert and/or reducing atmosphere at a temperature of at least 100 C., prior to the reaction stage.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2013.1.4-2 | Award Amount: 5.67M | Year: 2013

According to European Commission [EC, COM (2012) 572, 3.10.2012] important challenges at European level are related to the establishment of validated method and instrumentation for detection, characterization and analysis of nanoparticles. In the framework of the SETNanometro project, the use of various measurement techniques for the determination of the NPs properties will allow to move from the currently used trial and error approach toward the development of well defined and controlled protocols for the production of TiO2 NPs. A particular care will be devoted to the establishment of correct metrological traceability chain in order to ensure the reliability of the results. The lack of international measurement standards for calibration is an aspect of particular relevance in nanotechnologies as it is difficult to select a universal calibration artefact to achieve repeatability at nanoscale. The materials produced according to such procedures, will be hence sufficiently characterised and homogeneous in their properties to become candidate Certified Reference Materials to be used in various applications where the lack of metrological traceability is encountered. The project results are expected to lead to fundamental impacts on the following areas: Environment: the increased knowledge of TiO2 NPs will improve the photocatalytic properties for the treatment of pollutants in air and water Energy: the better knowledge of dimension and electronic structure of TiO2 will allow to improve the traceability of DSSC measurements. Health: the engineering of topographic and surface composition of TiO2 nanostructured coatings of orthopaedic and dental prostheses will support the design of rules for the production of devices exhibiting otpimized interfacial properties for a better and quicker integration of the implants in the hosting bone tissues.

Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: PEOPLE-2007-1-1-ITN | Award Amount: 2.84M | Year: 2008

COSI integrates young researchers in a network of 10 leading European research centres, including Bayer BioScience as industrial partner. We aim at identification of regulatory principles governing chloroplast metabolism, a crucial factor for agricultural productivity. Specifically we want to identify chloroplast-related protein kinases and their targets and associated calcium signals. A long term objective of COSI is increased plant productivity under stress conditions. COSI has expertise in various aspects of photosynthesis in algae and higher plants and in plant signal transduction. This unique combination will be used to identify major regulatory principles of plant organellar metabolism principally also applying far beyond the plant field. Thus training and knowledge can be transferred to many other fields in life sciences. An integrated working programme consisting of working packages, jointly coordinated by two groups of the network, guarantees maximal use of complementary expertises and strengthens ongoing interactions between partners. In addition to intensive exchange and collaboration of the involved young researchers, special training courses will introduce the young researchers in basic methods, which are required for their work and furthermore help them to develop complementary skills. Early stage researchers will be supported by a mentoring programme to enhance their personnel development. Special emphasis will be placed on promotion of women. A training course at Bayer BioScience will expose young researchers to an industrial environment and provide them with industrial relevant skills. COSI will offer hands-on training in cutting-edge technologies such as bioinformatics, live-cell imaging, mass spectrometry and metabolomics and establish an outstanding European research community in organellar signal transduction, an emerging new and competitive research field of central importance in life sciences.

Agency: Cordis | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2013-IRSES | Award Amount: 480.90K | Year: 2014

Mobile Cloud Computing emerges as a new computing paradigm where mobile devices exploit the available cloud computing platform for performing specific tasks and/or accessing data on demand rather than on the individual devices themselves. A key element missing in current mobile cloud computing design is the need of sufficient consideration on mobile network bandwidth availability and energy consumption for both cloud computing devices and mobile devices. MobileCloud project aims to bridge this gap, addressing how mobile cloud computing services can be delivered in such environments in a highly efficient and energy-efficient manner. The proposed joint exchange project aims to provide a stimulating and structured platform for the exchange of researchers and for the joint development of innovative ideas in the emerging areas within mobile cloud computing and beyond. To achieve this goal, a broad combination of eight universities and research institutions in Europe and China will collaborate together and create a multidisciplinary (cloud computing, mobile computing, telecommunications, computer systems and network optimization) and international (China plus four EU member states) environment for an innovative research experience and knowledge exchange in mobile cloud computing. The specific S&T objectives of MobileCloud are to jointly investigate innovative methodologies and approaches to optimize mobile cloud computing resources and satisfy service requirements including energy efficiency and high resource utilization in the emerging cloud computing era. Our team comprising researchers with complementary expertise is very well positioned to design, develop and evaluate the mobile cloud computing technology, contributing to a new low-energy, scalable and highly efficient networking and computing paradigm. Our efforts will foster continued close cooperations and new collaboration opportunities between research communities of Europe and China.

French Institute of Health, Medical Research, University of Paris Descartes, University Pierre, Marie Curie and Assistance Publique Hopitaux De Paris Aphp | Date: 2014-06-20

The present invention relates to method and pharmaceutical compositions for preventing glucocorticoid-induced corneal or skin thinning. In particular, the present invention relates to a mineralocorticoid receptor antagonist for topical use in a method for preventing or reducing glucocorticoid-induced corneal or skin thinning in a subject in need thereof. The invention also relates to a topical pharmaceutical composition comprising an amount of at least one glucocorticoid and an amount of at least one mineralocorticoid receptor antagonist or inhibitor of MR expression for use in a method for treating an inflammatory skin disease or an inflammatory disease of the cornea or of the anterior segment of the eye in a subject in need thereof.

University Pierre, Marie Curie, French Institute of Petroleum and Catholic University of Louvain | Date: 2012-07-11

A process for metathesis of olefins, bringing olefins into contact with a catalyst activated by heating to a temperature in the range 100 C. to 1000 C. in an atmosphere of non-reducing gas, the catalyst containing at least one inorganic material having at least two elementary spherical particles, each of which are metal oxide particles with a size of at most 300 nm and containing at least one of tungsten, molybdenum, rhenium, cobalt, tin, ruthenium, iron or titanium, alone or a mixture, the metal oxide particles being present within a mesostructured matrix of an oxide of at least one element Y: silicon, aluminium, titanium, tungsten, zirconium, gallium, germanium, tin, antimony, lead, vanadium, iron, manganese, hafnium, niobium, tantalum, yttrium, cerium, gadolinium, europium or neodymium or a mixture thereof, the matrix having pore size 1.5 to 50 nm and amorphous walls with thickness 1 to 30 nm and maximum diameter of 200 m.

French National Center for Scientific Research, French Institute of Petroleum, University Pierre and Marie Curie | Date: 2011-12-15

An inorganic material is described, constituted by at least two elementary spherical particles, each of said spherical particles comprising metallic nanoparticles having at least one band with a wave number in the range 750 to 1050 cm^(1 )in Raman spectroscopy and containing one or more metals selected from vanadium, niobium, tantalum, molybdenum and tungsten, said metallic nanoparticles being trapped in a mesostructured matrix based on an oxide of an element Y selected from silicon, aluminium, titanium, tungsten, zirconium, gallium, germanium, tin, antimony, lead, vanadium, iron, manganese, hafnium, niobium, tantalum, yttrium, cerium, gadolinium, europium and neodymium. Said matrix has pores with a diameter in the range 1.5 to 50 nm and amorphous walls with a thickness in the range 1 to 30 nm. Said elementary spherical particles have a maximum diameter of 200 microns and said metallic nanoparticles have a maximum dimension strictly less than 1 nm.

French National Center for Scientific Research, French Institute of Petroleum, University Pierre and Marie Curie | Date: 2011-12-15

Inorganic material having at least two elementary spherical particles, each of said spherical metallic particles: a polyoxometallate with formula (X_(x)M_(m)O_(y)H_(h))^(q), where H is hydrogen, O is oxygen, X is phosphorus, silicon, boron, nickel or cobalt and M is one or more vanadium, niobium, tantalum, molybdenum, tungsten, iron, copper, zinc, cobalt and nickel, x is 0, 1, 2 or 4, m is 5, 6, 7, 8, 9, 10, 11, 12 or 18, y is 17 to 72, h is 0 to 12 and q is 1 to 20.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.1.1 | Award Amount: 8.07M | Year: 2010

The Internet has evolved from a technology-centric core network to a user- and content-centric network that must support millions of users creating and consuming content. It must accommodate new services with new requirements and cope with heterogeneous network technologies. The momentum is moving toward the end user who is now capable of creating, storing, and delivering content and services. FIGARO proposes a Future Internet architecture that is structured around residential networks. In this architecture, home gateways have a key role as integrator of different networks and services, and as coordinator of Internet-wide distributed content management. FIGARO will: i) design a novel content management architecture that enables distributed content backup, search and access. This architecture will also support mobile users and wireless ad-hoc content sharing; ii) develop a network optimization framework, leveraging community networks and heterogeneous networks; iii) deliver a network management architecture which includes new network monitoring and real-time troubleshooting techniques; iv) explore novel Internet-based communication and service solutions for emerging sectors, such as energy management and e-health care.\nWe will deliver the components of the FIGARO architecture through an experimental approach incorporating testbed prototyping of solutions. In summary, FIGARO is intended to evolve the current Internet to meet future demands of applications, services and end-users, while preserving its current robustness and increasing its scalability and efficiency. Furthermore, the integration of new sectors into the future Internet will spur trans-sector innovation and create new businesses. The project is expected to result in technologies that will strengthen Europes position and give competitive advantage to European industry in the areas of Future Internet technologies and services, residential gateways and home automation.

Chattoraj J.,University Paris Est Creteil | Caroli C.,University Pierre and Marie Curie | Lemaitre A.,University Paris Est Creteil
Physical Review Letters | Year: 2010

Extensive measurements of macroscopic stress in a 2D Lennard-Jones glass, over a broad range of temperatures (T) and strain rates (γ̇), demonstrate a very significant decrease of the flowing stress with T, even much below the glass transition. A detailed analysis of the interplay between loading, thermal activation, and mechanical noise leads us to propose that over a broad (γ̇, T) region, the effect of temperature amounts to a mere lowering of the strains at which plastic events occur, while the athermal avalanche dynamics remains essentially unperturbed. Up to the vicinity of the glass transition, temperature is then shown to correct the athermal stress by a (negative) additive contribution which presents a universal form, thus bringing support to and extending an expression proposed by Johnson and Samwer. © 2010 The American Physical Society.

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