Orsay, France
Orsay, France

University of Paris-Sud is a French university distributed among several campuses in the southern suburb of Paris . The main campus is located in Orsay . This university is a member of the UniverSud Paris.Paris-Sud is one of the largest and most renowned French universities, particularly in science and mathematics. Paris-Sud is ranked 2nd in France, 7th in Europe and 39th worldwide by the 2013 Academic Ranking of World Universities . Furthermore, in this latest edition of ARWU ranking, the university is ranked 15th globally in the field of Natural science and Mathematics; in the five general subject rankings, the university is ranked 7th in mathematics and 19th in physics. Wikipedia.


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Patent
French National Center for Scientific Research and University Paris - Sud | Date: 2015-04-09

The invention relates to compounds which are inhibitors of the polymerization of tubulin, to the methods for the production thereof, and to the uses of same.


Patent
Laboratoire Francais Du Fractionnement Et Des Biotechnologies, French National Center for Scientific Research and University Paris - Sud | Date: 2015-05-28

Disclosed is a copolymer of following formula (I): in which:x is an integer between 10 and 250, preferably between 40 and 120, y is an integer between 4 and 100, preferably between 10 and 100, preferably between 19 and 60, z is an integer between 0 and (100y), preferably equal to 0, R represents an alkyl radical having 1 to 10 carbon atoms, a phospholipid, a glycosaminoglycan or an affinity ligand, and R represents a hydrogen, the CH_(2)CCH group, a CH_(2)-1H-1,2,3-triazole group, a CH_(2)CH_(2)CH_(2)SR group, in which R represents an alkyl radical having 1 to 10 carbon atoms, a phospholipid, a glycosaminoglycan, an affinity ligand or an imaging probe, and the uses of same.


Patent
University Paris - Sud, French Atomic Energy Commission and French National Center for Scientific Research | Date: 2015-04-03

Complexes including a solid support and a material with a matrix structure containing domains complexing rare earth or strategic metals, preparation process thereof and use thereof for extracting or separating the rare earth or strategic metals in an aqueous or organic medium.


Patent
University Paris - Sud and Lille University Hospital Center | Date: 2015-04-16

The invention relates to an isolated monoclonal antibody that specifically binds to the D4 domain of VWF, competes for binding to VWF D4 domain with ADAMTS13 and partially inhibits ADAMTS 13 -mediated degradation of VWF. More particularly, the invention relates to an isolated monoclonal antibody comprising a heavy chain wherein the variable domain comprises at least one CDR having a sequence selected from the group consisting of SEQ ID NO: 3 for H-CDR1, SEQ ID NO: 4 for H-CDR2 and SEQ ID NO: 5 for H-CDR3 and a light chain wherein the variable domain comprises at least one CDR having a sequence selected from the group consisting of SEQ ID NO: 7 for L-CDR1, SEQ ID NO: 8 for L-CDR2 and SEQ ID NO: 9 for L-CDR3. Antibodies of the invention are presented to be useful in for the prevention or the treatment of bleeding episodes, such as bleeding episodes occurring in patients with aortic stenosis or patients with ventricular assist devices (VAD).


Patent
University Paris - Sud | Date: 2017-01-25

The invention relates to a method for inducing human cholangiocyte differentiation of progenitor cells called hepatoblasts. More specifically, the invention relates to a method for differentiating hepatoblasts to cholangiocytes by culturing said hepatoblasts with a particular medium having interleukin-6 (IL-6) activity. The differentiation method can specifically induce cholangiocyte differentiation from hepatoblasts, and the human cholangiocytes differentiated according to the invention may be useful for drug discovery for treatment of cholangiopathies and bioengineered livers.


Patent
French National Center for Scientific Research and University Paris - Sud | Date: 2017-02-15

The invention relates to compounds which are inhibitors of the polymerisation of tubulin, to the methods for the production thereof, and to the uses of same.


Goerbig M.O.,University Paris - Sud
Reviews of Modern Physics | Year: 2011

The basic aspects of electrons in graphene (two-dimensional graphite) exposed to a strong perpendicular magnetic field are reviewed. One of its most salient features is the relativistic quantum Hall effect, the observation of which has been the experimental breakthrough in identifying pseudorelativistic massless charge carriers as the low-energy excitations in graphene. The effect may be understood in terms of Landau quantization for massless Dirac fermions, which is also the theoretical basis for the understanding of more involved phenomena due to electronic interactions. The role of electron-electron interactions both in the weak-coupling limit, where the electron-hole excitations are determined by collective modes, and in the strong-coupling regime of partially filled relativistic Landau levels are presented. In the latter limit, exotic ferromagnetic phases and incompressible quantum liquids are expected to be at the origin of recently observed (fractional) quantum Hall states. Furthermore, the electron-phonon coupling in a strong magnetic field is discussed. Although the present review has a dominant theoretical character, a close connection with available experimental observation is intended. © 2011 American Physical Society.


Langevin D.,University Paris - Sud
Annual Review of Fluid Mechanics | Year: 2014

When surfactants adsorb at liquid surfaces, they not only decrease the surface tension, they also confer rheological properties to the surfaces. The most common rheological parameters are the surface compression elasticity and viscosity and the surface shear viscosity. These parameters usually depend on the timescale of the deformation, owing to surface relaxations, and on its amplitude, owing to nonlinear responses. In addition, surfactants can exchange between the bulk and surface, in a way that depends on the amount of bulk surfactant locally available. This complexity explains why the topic has progressed slowly over the years. This review describes the current knowledge, focusing on recent advances, and gives examples of phenomena in which surface rheology plays an important role. Copyright © 2014 by Annual Reviews. All rights reserved.


Several autoimmune diseases, including primary Sjögren's syndrome (pSS), are associated with an increased risk for lymphoma. Polymorphisms of TNFAIP3, which encodes the A20 protein that plays a key role in controlling nuclear factor κB activation, have been associated with several autoimmune diseases. Somatic mutations of TNFAIP3 have been observed in the mucosa-associated lymphoid tissue lymphoma subtype frequently associated with pSS. We studied germline and somatic abnormalities of TNFAIP3 in 574 patients with pSS, including 25 with lymphoma. Nineteen additional patients with pSS and lymphoma were available for exome sequence analysis. Functional abnormalities of A20 were assessed by gene reporter assays. The rs2230926 exonic variant was associated with an increased risk for pSS complicated by lymphoma (odds ratio, 3.36 [95% confidence interval, 1.34-8.42], and odds ratio, 3.26 [95% confidence interval, 1.31-8.12], vs controls and pSS patients without lymphoma, respectively; P = .011). Twelve (60%) of the 20 patients with paired germline and lymphoma TNFAIP3 sequence data had functional abnormalities of A20: 6 in germline DNA, 5 in lymphoma DNA, and 1 in both. The frequency was even higher (77%) among pSS patients with mucosa-associated lymphoid tissue lymphoma. Some of these variants showed impaired control of nuclear factor κB activation. These results support a key role for germline and somatic variations of A20 in the transformation between autoimmunity and lymphoma.


Dussaux A.,University Paris - Sud
Nature communications | Year: 2010

Spin-polarized current can excite the magnetization of a ferromagnet through the transfer of spin angular momentum to the local spin system. This pure spin-related transport phenomenon leads to alluring possibilities for the achievement of a nanometer scale, complementary metal oxide semiconductor-compatible, tunable microwave generator that operates at low bias for future wireless communication applications. Microwave emission generated by the persistent motion of magnetic vortices induced by a spin-transfer effect seems to be a unique manner to reach appropriate spectral linewidth. However, in metallic systems, in which such vortex oscillations have been observed, the resulting microwave power is much too small. In this study, we present experimental evidence of spin-transfer-induced vortex precession in MgO-based magnetic tunnel junctions, with an emitted power that is at least one order of magnitude stronger and with similar spectral quality. More importantly and in contrast to other spin-transfer excitations, the thorough comparison between experimental results and analytical predictions provides a clear textbook illustration of the mechanism of spin-transfer-induced vortex precession.

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