University of Paris-Sud is a French university distributed among several campuses in the southern suburb of Paris . The main campus is located in Orsay . This university is a member of the UniverSud Paris.Paris-Sud is one of the largest and most renowned French universities, particularly in science and mathematics. Paris-Sud is ranked 2nd in France, 7th in Europe and 39th worldwide by the 2013 Academic Ranking of World Universities . Furthermore, in this latest edition of ARWU ranking, the university is ranked 15th globally in the field of Natural science and Mathematics; in the five general subject rankings, the university is ranked 7th in mathematics and 19th in physics. Wikipedia.
French Institute of Health, Medical Research, French National Center for Scientific Research, University of Paris Descartes, Fondation Imagine, University Paris Diderot, University Paris - Sud and Assistance Publique Hopitaux De Paris Aphp | Date: 2015-06-19
The present invention concerns a combination of (i) a DNA methylation inhibitor, and (ii) a Vitamin D receptor agonist, for simultaneous or sequential use in the treatment of a drug resistant cancer and/or in prevention of tumor relapse in a patient suffering from cancer. The present invention also relates to a combination of (i) a DNA methylation inhibitor, and (ii) a Vitamin D receptor agonist, for increasing, restoring or enhancing sensitivity of a patient suffering from cancer to a chemotherapeutic drug in a patient suffering from cancer.
Cisbio Bioassays, French National Center for Scientific Research and University Paris - Sud | Date: 2017-05-10
The present invention relates to anti- metabotropic glutamate receptor subtype 2 (mGluR2) conformational single domain antibodies and uses thereof in particular in the therapeutic and diagnostic field.
French Institute of Health, Medical Research, University Paris - Sud and University of Bordeaux 1 | Date: 2016-12-28
The present invention relates to polypeptides and their uses as apelin inhibitors. More particularly, the present invention relates to a polypeptide comprising the sequence as set forth in SEQ ID NO:1 wherein at least one arginine residue at position 18, 19, 22 or 23 has been substituted or deleted.
University Paris - Sud | Date: 2017-01-25
The invention relates to a method for inducing human cholangiocyte differentiation of progenitor cells called hepatoblasts. More specifically, the invention relates to a method for differentiating hepatoblasts to cholangiocytes by culturing said hepatoblasts with a particular medium having interleukin-6 (IL-6) activity. The differentiation method can specifically induce cholangiocyte differentiation from hepatoblasts, and the human cholangiocytes differentiated according to the invention may be useful for drug discovery for treatment of cholangiopathies and bioengineered livers.
French National Center for Scientific Research and University Paris - Sud | Date: 2017-02-15
The invention relates to compounds which are inhibitors of the polymerisation of tubulin, to the methods for the production thereof, and to the uses of same.
University Paris - Sud and French National Center for Scientific Research | Date: 2015-07-17
An electronic device with a circuit for supplying electric power, with a variable capacitor, by alternating mechanical movement. The supply includes, in the form of passive components and without synchronizing structure: A circuit includes a voltage multiplier connected to the biasing node for applying a voltage that is multiplied relative to that existing between
French National Center for Scientific Research and University Paris - Sud | Date: 2017-07-12
The present invention relates to a microfluidic analysis device (1) including: a substrate (20) wherein a separation channel (10) is arranged, in which an electrolyte flows, a portion of the separation channel (10) being covered with a polarisable surface (11); two longitudinal field electrodes (8a, 8b) arranged on either side of the separation channel (10); at least one control electrode (6a, 6b) positioned in the separation channel (10), the control electrode (6a, 6b) being suitable for polarising the polarisable surface (11) so as to control the speed of the electro-osmotic flow in the separation channel (10); the microfluidic analysis device (1) being characterised in that the polarisable surface (11) includes an insulating sub-layer (12) made of amorphous silicon carbide (SiC) and an upper polarisable layer (13) in direct contact with the electrolyte, the control electrodes (6a, 6b) being positioned between the insulating sub-layer (12) and the upper polarisable layer (13).
French National Center for Scientific Research and University Paris - Sud | Date: 2017-08-09
According to one aspect, the invention relates to a device (100, 200, 300, 400, 500) for measuring the distance, with respect to a reference plane (PREF), of a point of light (Pi) of an object (O). The device comprises a two-dimensional detector (30) comprising a detection plane (PDET) and an imaging system (10) capable of forming an image of a point of light (Pi) situated on an object plane of interest (11) in an image plane (11) arranged close to the detection plane (PDET) or to a conjugate plane (PDET) of the detection plane. The device further comprises a separator element (20) able to form, from a beam emitted by a point of light of the object plane of interest (11) and emerging from the imaging system (10), at least two mutually coherent beams, having a region of special superposition in which the beams interfere, and signal processing means (50) able to determine, from the interference pattern formed in the detection plane and resulting from the optical interference between said mutually coherent beams, the distance from the point of light to the conjugate plane of the detection plane in the object space of the imaging system (10), said conjugate plane of the detection plane forming the reference plane (PREF).
French National Center for Scientific Research and University Paris - Sud | Date: 2017-07-19
The present invention concerns compounds of formula (I), enantiomers, mixture of enantiomers, diastereoisomers and mixture of diasteroisomers thereof formual (I): wherein at least one of W, X and Y is selected from the group consisting of -NR1R2; - NR3-(CH2)n-NR4R5; -O-(CH2)n-NR4R5; -NR3-(CH2)n-N+R6R7R8; and -O-(CH2)n-N+R6R7R8 and Z is a functional group capable of chelating iron salts. The present invention also concerns the compounds of formula (I) for use as a drug, in particular, in the treatment of cancer and malaria.
Goerbig M.O.,University Paris - Sud
Reviews of Modern Physics | Year: 2011
The basic aspects of electrons in graphene (two-dimensional graphite) exposed to a strong perpendicular magnetic field are reviewed. One of its most salient features is the relativistic quantum Hall effect, the observation of which has been the experimental breakthrough in identifying pseudorelativistic massless charge carriers as the low-energy excitations in graphene. The effect may be understood in terms of Landau quantization for massless Dirac fermions, which is also the theoretical basis for the understanding of more involved phenomena due to electronic interactions. The role of electron-electron interactions both in the weak-coupling limit, where the electron-hole excitations are determined by collective modes, and in the strong-coupling regime of partially filled relativistic Landau levels are presented. In the latter limit, exotic ferromagnetic phases and incompressible quantum liquids are expected to be at the origin of recently observed (fractional) quantum Hall states. Furthermore, the electron-phonon coupling in a strong magnetic field is discussed. Although the present review has a dominant theoretical character, a close connection with available experimental observation is intended. © 2011 American Physical Society.