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Montigny-lès-Metz, France

Candelier J.-J.,French Institute of Health and Medical Research | Candelier J.-J.,University Of Paris Saclay
Cell Adhesion and Migration | Year: 2016

The hydatidiform mole (HM) is a placental pathology of androgenetic origin. Placental villi have an abnormal hyperproliferation event and hydropic degeneration. Three situations can be envisaged at its origin: 1. The destruction/expulsion of the female pronucleus at the time of fertilization by 1 or 2 spermatozoa with the former being followed by an endoreplication of the male pronucleus leading to a complete hydatidiform mole (CHM) 2. A triploid zygote (fertilization by 2 spermatozoa) leading to a partial hydatidiform mole (PHM) but can also lead to haploid and diploid clones. The diploid clone may produce a normal fetus while the haploid clone after endoreplication generates a CHM 3. A nutritional defect during the differentiation of the oocytes or the deterioration of the limited oxygen pressure during the first trimester of gestation may lead to the formation of a HM. In countries with poor medical health care system, moles (mainly the CHM) can become invasive or, in rare cases, lead to gestational choriocarcinomas. © 2016 Taylor & Francis Group, LLC.

Sukkurwala A.Q.,French Institute of Health and Medical Research | Sukkurwala A.Q.,Gustave Roussy Comprehensive Cancer Center | Adjemian S.,French Institute of Health and Medical Research | Adjemian S.,Gustave Roussy Comprehensive Cancer Center | And 21 more authors.
OncoImmunology | Year: 2014

Immunogenic cell death (IC D) inducers can be defined as agents that exert cytotoxic effects while stimulating an immune response against dead cell-associated antigens. When initiated by anthracyclines, IC D is accompanied by stereotyped molecular changes, including the pre-apoptotic exposure of calreticulin (CR T) on the cell surface, the lysosomal secretion of ATP during the blebbing phase of apoptosis, and the release of high mobility group box 1 (HMGB1) from dead cells. By means of genetically engineered human osteosarcoma U2OS cells, we screened the 879 anticancer compounds of the National Cancer Institute (NCI ) Mechanistic Diversity Set for their ability to promote all these hallmarks of IC D in vitro. In line with previous findings from our group, several cardiac glycosides exhibit a robust propensity to elicit the major manifestations of IC D in cultured neoplastic cells. This screen pointed to septacidin, an antibiotic produced by Streptomyces fibriatus, as a novel putative inducer of IC D. In low-throughput validation experiments, septacidin promoted CR T exposure, ATP secretion and HG MB1 release from both U2OS cells and murine fibrosarcoma MCA 205 cells. Moreover, septacidin-killed MCA 205 cells protected immunocompetent mice against a re-challenge with live cancer cells of the same type. Finally, the antineoplastic effects of septacidin on established murine tumors were entirely dependent on T lymphocytes. Altogether, these results underscore the suitability of the high-throughput screening system described here for the identification of novel IC D inducers. © 2014 Landes Bioscience.

Suchanek F.M.,University Of Paris Saclay | Preda N.,University of Versailles
Proceedings of the VLDB Endowment | Year: 2014

Newspapers are testimonials of history. The same is increasingly true of social media such as online forums, online communities, and blogs. By looking at the sequence of articles over time, one can discover the birth and the development of trends that marked society and history - a field known as "Culturomics". But Culturomics has so far been limited to statistics on keywords. In this vision paper, we argue that the advent of large knowledge bases (such as YAGO [37], NELL [5], DBpedia [3], and Freebase) will revolutionize the field. If their knowledge is combined with the news articles, it can breathe life into what is otherwise just a sequence of words for a machine. This will allow discovering trends in history and culture, explaining them through explicit logical rules, and making predictions about the events of the future. We predict that this could open up a new field of research, "Semantic Culturomics", in which no longer human text helps machines build up knowledge bases, but knowledge bases help humans understand their society.© 2014 VLDB Endowment 2150-8097/14/08.

Taguett A.,University of Savoy | Aubert T.,University of Savoy | Aubert T.,University Of Paris Saclay | Aubert T.,University of Lorraine | And 6 more authors.
Sensors and Actuators, A: Physical | Year: 2016

The achievement of surface acoustic wave (SAW) devices stable in higherature oxidizing atmospheres requires the development of conductive thin film electrodes that can withstand such harsh conditions. Recent studies have demonstrated the suitability of Pt-based alloys, multilayers or nanocomposite films for temperatures up to 800 °C. Electrodes based on new materials and structures still have to be developed for applications taking place at higher temperatures. In this perspective, thin films based on iridium could be good candidates regarding the high melting point, and thus the low diffusion coefficients of this noble metal. In particular, Ir-Rh bulk alloys have shown superior performance as spark plug electrodes, which have to resist concurrently to physical and chemical wear such as higherature SAW electrodes. Consequently, this paper deals with the higherature behavior of Ir-Rh thin films. Ir-Rh alloys and multilayers films, with an Ir atomic ratio between 10 and 50%, are deposited by one-gun electron beam evaporation method. The impact on the films of a 4 days annealing treatment at 800 °C in air is studied by X-ray diffraction, scanning and transmission electron microscopy, electron energy loss spectroscopy and four-points probe resistivity measurements. It turns out that all the films oxidized during the annealing period. The post-annealing electrical properties are highly dependent of the initial composition of the film: The higher is the Ir rate in the film, the lower is the electrical resistivity after annealing. Moreover, an Rh2O3 overlayer, with a thickness of some tens of nanometers, forms at the surface of the film, confirming previous observations made on Ir-Rh bulk alloys. First SAW measurements made on devices based on Ir30Rh70 alloy electrodes are very promising as a SAW signal is still clearly visible after the 4 days annealing process, while no agglomeration phenomenon can be observed. © 2016 Elsevier B.V. All rights reserved.

Legrani O.,CNRS Jean Lamour Institute | Legrani O.,University Of Paris Saclay | Legrani O.,University of Lorraine | Aubert T.,University Of Paris Saclay | And 9 more authors.
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control | Year: 2016

Recent studies have evidenced that Pt/AlN/Sapphire surface acoustic wave (SAW) devices are promising for high-temperature high-frequency applications. However, they cannot be used above 700°C in air atmosphere as the Pt interdigital transducers (IDTs) agglomerate and the AlN layer oxidizes in such conditions. In this paper, we explore the possibility to use an AlN protective overlayer to concurrently hinder these phenomena. To do so, AlN/IDT/AlN/Sapphire heterostructures undergo successive annealing steps from 800°C to 1000°C in air atmosphere. The impact of each step on the morphology, microstructure, and phase composition of AlN and Pt films is evaluated using optical microscopy, scanning and transmission electron microscopy (SEM and TEM), X-ray diffraction (XRD), and secondary ion mass spectroscopy (SIMS). Finally, acoustical performance at room temperature of both protected and unprotected SAW devices are compared, as well as the effects of annealing on these performance. These investigations show that the use of an overlayer is one possible solution to strongly hinder the Pt IDTs agglomeration up to 1000°C. Moreover, AlN/IDT/AlN/Sapphire SAW heterostructures show promising performances in terms of stability up to 800°C. At higher temperatures, the oxidation of AlN is more intense and makes it inappropriate to be used as a protective layer. © 2016 IEEE.

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