Paris-Est Créteil Val-de-Marne University was inaugurated in 1970. It is a multidisciplinary centre based principally in Créteil . The university offers training in law, arts and humanities, science and technology, economics and development, administration and exchange, educational science, as well as social science. Val de Marne University is composed of seven departements and seven institutes situated in Vitry-sur-Seine , Seine-et-Marne, and in the 14th arrondissement of Paris. Wikipedia.
Soize C.,University Paris Est Creteil
Journal of Sound and Vibration | Year: 2013
This paper deals with a short overview on stochastic modeling of uncertainties. We introduce the types of uncertainties, the variability of real systems, the types of probabilistic approaches, the representations for the stochastic models of uncertainties, the construction of the stochastic models using the maximum entropy principle, the propagation of uncertainties, the methods to solve the stochastic dynamical equations, the identification of the prior and the posterior stochastic models, the robust updating of the computational models and the robust design with uncertain computational models. We present recent theoretical advances in this field concerning the parametric and the nonparametric probabilistic approaches of uncertainties in computational structural dynamics for the construction of the prior stochastic models of both the uncertainties on the computational model parameters and on the modeling uncertainties, and for their identification with experimental data. We also present the construction of the posterior stochastic model of uncertainties using the Bayesian method when experimental data are available. © 2011 Elsevier Ltd All rights reserved.
Hezode C.,University Paris Est Creteil
Liver International | Year: 2012
Effective management of adverse events (AEs) is important to prevent treatment discontinuation and optimize hepatitis C virus infection eradication rates. The addition of direct-acting antiviral agents, telaprevir (TVR) or boceprevir to pegylated interferon (PEG-IFN) and ribavirin (RBV) represents a new era of therapy associated with an improvement in treatment response rates and an impairment of the safety profile compared to PEG-IFN/RBV. An increase in the frequency and severity of anaemia was reported in clinical trials for both drugs, and skin disorders including rash and pruritus occurred more frequently with the TVR-based regimen. These AEs are generally manageable and do not lead to early discontinuation. The management of anaemia has not been clearly established, and the impact of RBV dose reductions and erythropoietin alpha use on treatment efficacy and safety must be clarified. The management of rashes, which were mild and moderate in more than 90% of the cases, is well planned, does not require TVR discontinuation and can be treated using emollients and topical corticosteroids. However, approximately 5% of rashes were severe, and a few cases were classified as severe cutaneous adverse reactions leading to treatment discontinuation. © 2012 John Wiley & Sons A/S.
Pawlotsky J.-M.,University Paris Est Creteil |
Pawlotsky J.-M.,French Institute of Health and Medical Research
Journal of Hepatology | Year: 2013
Summary Hepatitis C virus infection is a major health problem worldwide and no vaccine has yet been developed against this virus. In addition, currently approved pharmacotherapies achieve suboptimal cure rates and have side effects that result in non-compliance and premature treatment discontinuation. Significant research has been devoted to developing direct-acting antiviral agents that inhibit key viral functions. In particular, several novel drug candidates that inhibit the viral non-structural protein 5A (NS5A) have been demonstrated to possess high potency, pan-genotypic activity, and a high barrier to resistance. Clinical trials using combination therapies containing NS5A inhibitors have reported results that promise high cure rates and raise the possibility of developing interferon-free, all-oral regimens. © 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Lemaitre A.,University Paris Est Creteil
Physical Review Letters | Year: 2014
We show that in deeply supercooled liquids, structural relaxation proceeds via the accumulation of Eshelby events, i.e. local rearrangements that create long-ranged and anisotropic stresses in the surrounding medium. Such events must be characterized using tensorial observables and we construct an analytical framework to probe their correlations using local stress data. By analyzing numerical simulations, we then demonstrate that events are power-law correlated in space, with a time-dependent amplitude which peaks at the alpha relaxation time τα. This effect, which becomes stronger near the glass transition, results from the increasingly important role of local stress fluctuations in facilitating relaxation events. Our finding precludes the existence of any length scale beyond which the relaxation process decorrelates. © 2014 American Physical Society.
Leveziel N.,University Paris Est Creteil
American journal of ophthalmology | Year: 2013
To analyze the contribution of fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD OCT) to the diagnosis of recent choroidal neovascularization (CNV) associated with high myopia. Retrospective, observational case series. Ninety eyes of 73 highly myopic patients (refractive error ≥-6 diopters) with CNV in 1 or both eyes were included. Epidemiologic features, refractive error, fundus examination, fluorescein angiography, and SD OCT findings at onset of CNV were analyzed. Mean age at onset of CNV was 54.4 ± 14 years. CNV was bilateral in 17 of 73 cases. Mean refractive error was -13.9 ± 5.2 diopters. Myopic CNV was associated more frequently with patchy or geographic atrophy (P = .019). CNV was associated with exudative features on fluorescein angiography in 82% of cases (64/78), and on SD OCT in 48.6% of cases (36/74). There was no agreement about signs of active CNV between these 2 imaging methods (κ = 25.7 ± 10%; P = .0044). CNV area was significantly smaller in younger patients (<55 years) than in older patients (0.57 mm(2) vs 1.21 mm(2), respectively; P = .023). Exudative features of myopic CNV are more obvious on FA than on SD OCT, suggesting that fluorescein angiography should be performed when new-onset myopic CNV is suspected. Myopic CNV occurring in older patients (≥55 years) is larger than those seen in younger patients and resembles CNV associated with age-related macular degeneration. This suggests an overlap between myopic CNV in older patients and age-related macular degeneration. Copyright © 2013 Elsevier Inc. All rights reserved.