Medicina, Spain
Medicina, Spain

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Rodriguez-Dehli A.C.,Hospital San Agustin | Galan I.R.,Hospital San Agustin | Galan I.R.,CIBER ISCIII | Fernandez-Somoano A.,University OviedoAsturias | And 8 more authors.
Nutricion Hospitalaria | Year: 2015

Background and objectives: The vitamin D deficiency during pregnancy has been associated with adverse events during pregnancy and the postnatal child development. In this study we examined plasma levels of vitamin D [25(OH)D3] and factors associated with plasma deficiency and insufficiency in pregnant women in northern Spain. Methods: We analyzed data from 453 pregnant women participating in the INMA-Asturias cohort in which was determined 25(OH)D3 by high resolution liquid chromatography. Dietary intake of vitamin D was estimated through a food frequency validated questionnaire. We estimated the prevalence of deficiency [25(OH)D3 <20 ng / ml] and insufficiency [20 to 29.9 ng / ml] of vitamin D and analyzed the distribution of 25(OH)D3 per month extraction and other factors. Results: The mean concentration of 25(OH)D3 was 27.7 ng/ml (range 6.4 to 69.5). 27.4% of pregnant women had deficient levels and 35.3% inssuficient. Levels of 25(OH)D3 were higher in the summer months (median 34.1 ng/ml). There was a higher percentage of deficiency in pregnant women with overweight/obesity (34.5%) and under 25 years (47.8%). The average daily intake of vitamin D was 5.48 mg / day (SD 2.82 range 1.09 to 32.52). Intake during the months of October to May was associated with levels of 25(OH)D3. 8.6% reported taking supplements of vitamin D. Conclusions: We detected a high proportion of pregnant women with deficient or insufficient vitamin D levels, especially in the months of October to May, in pregnant women with overweight and obesity, and the youngest. © 2015, Grupo Aula Medica S.A. All rights reserved.


Alvarez-Martos I.,University OviedoAsturias | Alonso-Bartolome R.,University OviedoAsturias | Mulas Hernandez V.,University OviedoAsturias | Anillo A.,University OviedoAsturias | And 3 more authors.
Reactive and Functional Polymers | Year: 2016

In this paper, we report the synthesis of different types of water soluble poly(glycidyl methacrylate) (PGMA) derivatives containing alcohol, sulfonate, piperidyl, and dibencyl pendant groups. Their structures were characterized by infrared (IR), 1H NMR, 13C NMR, thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC). It was found that the on-surface modification with PGMA produces a high density of covalently attached island structures, which can be further functionalized. To obtain an insight of the applicability, the synthesized PGMA-derivatives were used as dynamic modifiers of SU-8/Pyrex® microfluidic chips. Their potential was proven by the separation of three model analytes with closely related structures (dopamine, DA, norepinephrine, NE, and epinephrine, E). Under the optimum conditions, baseline separation (Rs values of 1.3 ± 0.1 and 1.58 ± 0.03 for DA-NE and NE-E respectively) was achieved within 3 min. The fact that the PGMA-based polymers reported in this work are water soluble opens the possibility of their application in microchannel surface modification, but also in many other research fields such as materials science and biochemistry. © 2016 Elsevier B.V. All rights reserved.

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