Zagreb, Croatia
Zagreb, Croatia

The University of Zagreb is the largest Croatian university and the oldest continuously operating university in the area covering Central Europe south of Vienna and all of Southeastern Europe. As of 2011, University of Zagreb is ranked among the 500 Best Universities of the world by the Shanghai Academic Ranking of World Universities. Wikipedia.


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A connected optical waveguide structure comprises n four-port optical couplers, where n is greater than one; and n waveguide loops, each loop having a corresponding perimeter; wherein each of the n perimeters is different from each of the other n1 perimeters. In one embodiment, for any pair of the n loops, the ratio of the larger perimeter to the smaller perimeter is greater than five halves (5/2).


The present invention relates to the field of prevention and treatment of muscle atrophy. More particular, the present invention relates to a composition comprising hesperetin, (-) epicatechin and myricetin. The present invention further relates to the use of said composition as inhibitor and stimulator for signaling pathways.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC5-07-2015 | Award Amount: 6.65M | Year: 2016

The project MERCES is focused on the restoration of different degraded marine habitats, with the aim of: 1) assessing the potential of different technologies and approaches; 2) quantifying the returns in terms of ecosystems services and their socio-economic impacts; 3) defining the legal-policy and governance frameworks needed to optimize the effectiveness of the different restoration approaches. Specific aims include: a) improving existing, and developing new, restoration actions of degraded marine habitats; b) increasing the adaptation of EU degraded marine habitats to global change; c) enhancing marine ecosystem resilience and services; d) conducting cost-benefit analyses for marine restoration measures; e) creating new industrial targets and opportunities. To achieve these objectives MERCES created a multi-disciplinary consortium with skills in marine ecology, restoration, law, policy and governance, socio-economics, knowledge transfer, dissemination and communication. MERCES will start from the inventory of EU degraded marine habitats (WP1), conduct pilot restoration experiments (WP2, WP3, WP4), assess the effects of restoration on ecosystem services (WP5). The legal, policy and governance outputs will make effective the potential of marine restoration (WP6) and one dedicated WP will assess the socio-economic returns of marine ecosystems restoration (WP7). The transfer of knowledge and the links with the industrial stakeholders will be the focus of WP8. The results of MERCES will be disseminated to the widest audience (WP9). The project will be managed through a dedicated management office (WP10). MERCES will contribute to the Blue Growth by: i) improving the EU scientific knowledge on marine restoration, ii) contributing to EU Marine Directives; iii) implementing the Restoration Agenda, iv) enhancing the industrial capacity in this field, v) increasing the competitiveness of EU in the world market of restoration, and vi) offering new employment opportunities.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-30-2015 | Award Amount: 7.10M | Year: 2016

Connected smart objects have invaded our everyday life across multiple domains, e.g. home withautomation solutions, assisted living with sensors and wearables to monitor personal activities, smart transportation and environmental monitoring. IoT is evolving around a plethora of vertically isolated platforms, each specifically suited to given scenarios and often adopting non-standard, sometimes fully proprietary, protocols to control the variety of sensors, actuators and communication elements. symbIoTe comes to evolve this fragmented environment and provides an abstraction layer for a unified control view on various IoT platforms and sensing/actuating resources. symbIoTe designs and develops an IoT orchestration middleware capable of unified and secure access to physical and virtualized IoT resources; hierarchical and orchestrated discovery and control across multiple IoT platforms; federation of IoT controllers and resources for cooperative sensing/actuation tasks; seamless roaming of smart objects across smart spaces. symbIoTe builds its orchestration middleware on top of existing standards for protocols and interfaces, plus a number IoT platforms both proprietary (i.e. developed by its industrial partners) and from open source (e.g. OpenIoT). This unique set of backgrounds and foreground can result in a significant step forward in horizontal integration and federation of IoT domains. Five use cases with real large scale deployments have been selected to validate our vision in representative smart spaces: home/residence, educational campus, stadium, mobility and yachting. Engagement with real users is key in our validation process. With its research, symbIoTe can enable innovative business models for a large set of stakeholders of the IoT value chain, and particularly SMEs and new entrants in the IoT market. The consortium includes direct beneficiaries of these impacts, including small and large industry with IoT business and renowned research performers.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: ICT-22-2016 | Award Amount: 6.05M | Year: 2017

CRISS is a user-driven, flexible, scalable and cost-effective cloud-based digital learning ecosystem that allows the guided acquisition, evaluation and certification of digital competences in primary and secondary education, and easily scalable to other educational levels. CRISS proposes an innovative adaptive learning solution supported by the most advanced pedagogical methodologies and technologies that will be tested with a very large scale pilot with more than 490 schools including 25.400 students and 2.290 teachers across Europe. CRISS aim to contribute to the modernisation of the educational and training system at different levels: a) Support schools and educational institutions in the definition and creation of a curricular programming aligned to European and national policies, encouraging the active participation of all teachers and creating an interdisciplinary framework and highly diversified contents, activities and educational experiences for the acquisition and evaluation digital competences of students. b) Offers teachers and students an adaptive and intelligent environment for personalizing the process of teaching and learning that allows them to easily and dynamically generate and integrate programming a wide variety of new learning experiences and integrate new methodologies, fostering a creative and motivating use of technologies focused on minimizing the distance between digital competences acquired at school and the required in the labour market. c) Through its learning analytics module CRISS can generate an innovative and unique student ICT Dynamic Profile, showing strengths and weaknesses, achievements, interests, skills acquired, certification and other recognition, on the one hand facilitating the personalization of teaching / learning, and on the other the entry into the labour world. d) Thanks to its evaluation and certification of digital competences will contribute to the standardization of digital competences at European level.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: INFRADEV-02-2016 | Award Amount: 9.05M | Year: 2017

The European Solar Telescope (EST) will be a revolutionary Research Infrastructure that will play a major role in answering key questions in modern Solar Physics. This 4-meter class solar telescope, to be located in the Canary Islands, will provide solar physicists with the most advanced state-of-the-art observing tools to transform our understanding of the complex phenomena that drive the solar magnetic activity. The principal objective of the present Preparatory Phase is to provide both the EST international consortium and the funding agencies with a detailed plan regarding the implementation of EST. The specific objectives of the proposed preparatory phase are: (1) to explore possible legal frameworks and related governance schemes that can be used by agencies to jointly establish, construct and operate EST as a new research infrastructure, with the implementation of an intermediate temporary organisational structure, as a previous step for future phases of the project; (2) to explore funding schemes and funding sources for EST, including a proposal of financial models to make possible the combination of direct financial and in-kind contributions towards the construction and operation of EST; (3) to compare the two possible sites for EST in the Canary Islands Astronomical Observatories and prepare final site agreements; (4) to engage funding agencies and policy makers for a long-term commitment which guarantees the construction and operation phases of the Telescope; (5) to involve industry in the design of EST key elements to the required level of definition and validation for their final production; (6) to enhance and intensify outreach activities and strategic links with national agencies and the user communities of EST. To accomplish the aforementioned goals, this 4-year project, promoted by the European Association for Solar Telescopes (EAST) and the PRE-EST consortium, encompassing 23 research institutions from 16 countries, will set up the Project Office


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-20-2015 | Award Amount: 6.91M | Year: 2016

Strength2Food is a 5-year, 6.9 million project to improve the effectiveness of EU food quality schemes (FQS), public sector food procurement (PSFP) and to stimulate Short Food Supply Chains (SFSC) through research, innovation and demonstration activities. Our 30-partner consortium representing 11 EU and 4 non-EU countries combines leading academic, communication, SME and stakeholder organisations to ensure a multi-actor approach. It will undertake case study-based quantitative research to measure economic, environmental and social impacts of FQS, PSFP and SFSC. The impact of PSFP policies on balanced nutrition in schools will also be assessed. Primary research will be complemented by advanced econometric analysis of existing datasets to determine impacts of FQS and SFSC participation on farm performance and survival, as well as understand price transmission and trade patterns. Consumer knowledge, confidence in, valuation and use of FQS labels and products will be assessed via cross-national survey, ethnographic and virtual supermarket-based research. Lessons from the research will be applied and verified in 6 pilot initiatives, focusing on less-developed and transition regions. These initiatives bring together academic and non-academic stakeholder partners in action research. The six pilot actions are: a school meals initiative to improve the nutritional outcomes and economic benefits for local agri-food producers; in-store trials (undertaken with a grocery retailer) to upscale sales of local produce; a scheme to stimulate a sustainable SFSC that adds value to the fishing community; and pilot actions to expand regional food labelling; increase sales of FQS products in non-traditional markers; and improve returns to local producers at food fairs and farmers markets (via a smartphone app). Project impact will be maximised through a knowledge exchange platform, hybrid forums, school educational resources, a Massive Open Online Course and practitioner recommendations.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-24-2015 | Award Amount: 4.62M | Year: 2016

The European market for e-commerce is growing rapidly, with more than 16% just in the year 2014. With the internationalization of distribution chains, the key for success lies within efficient logistics. In such facilities, goods for the end-user or products in the B2B sector are stored, commissioned and shipped. To manage the supply chains, many new warehouses have been erected and more will follow. With the growing markets, the need for larger warehouses and their automation increases. To advance the position of the European trade sector, technical restrictions on the size of warehouses should be avoided and new automation paradigm should be implemented to ensure their efficient operation. Therefore the European robotic and automation companies should be able to provide appropriate solutions, making scalable systems and scalable software mandatory. Current automation solutions based on strict separation of humans and robots cannot provide such efficient operation of large warehouses. SafeLog aims to overcome this issue by enabling much more efficient warehouse concepts joining human and robot workforce. Given that, the overall objective of SafeLog is the conception and implementation of a large-scale flexible warehouse system which enables safe and efficient collaboration of humans and robots in the same area and at the same time. On the way to reach this objective SaveLog will develop, integrate and test: (1) a holistic and certifiable safety concept based on the safety vest, which allows the collaboration of robots and humans in a flexible warehouse system, (2) planning and scheduling algorithms for a heterogeneous fleet manager, which allow the adhoc reactive planning and scheduling for human and robot workforce in a flexible warehouse system, and (3) augmented reality based interaction strategies to support workers in a robotized warehouse system with information about their current task and environment.


Orsolic N.,University of Zagreb
Cancer and Metastasis Reviews | Year: 2012

Bee venom (BV) (api-toxin) has been widely used in the treatment of some immune-related diseases, as well as in recent times in treatment of tumors. Several cancer cells, including renal, lung, liver, prostate, bladder, and mammary cancer cells as well as leukemia cells, can be targets of bee venom peptides such as melittin and phospholipase A2. The cell cytotoxic effects through the activation of PLA2 by melittin have been suggested to be the critical mechanism for the anti-cancer activity of BV. The induction of apoptotic cell death through several cancer cell death mechanisms, including the activation of caspase and matrix metalloproteinases, is important for the melittin-induced anti-cancer effects. The conjugation of cell lytic peptide (melittin) with hormone receptors and gene therapy carrying melittin can be useful as a novel targeted therapy for some types of cancer, such as prostate and breast cancer. This review summarizes the current knowledge regarding potential of bee venom and its compounds such as melittin to induce cytotoxic, antitumor, immunomodulatory, and apoptotic effects in different tumor cells in vivo or in vitro. The recent applications of melittin in various cancers and a molecular explanation for the antiproliferative properties of bee venom are discussed. © 2011 Springer Science+Business Media, LLC.


Reiner Z.,University of Zagreb
Nature Reviews Cardiology | Year: 2013

Statins are widely used in the evidence-based lowering of cardiovascular disease (CVD) risk. The use of these drugs for secondary prevention of CVD is well founded, but their expanding use in primary prevention - in individuals without documented CVD - has raised some concerns. Firstly, evidence suggests that, in primary prevention, statins substantially decrease CVD morbidity, but only moderately reduce CVD mortality. Secondly, long-term statin use might cause adverse effects, such as incident diabetes mellitus. Thirdly, the cost-effectiveness of such a strategy is unclear, and has to be balanced against the risk of 'overmedicating' the general population. Data clearly support the use of statins for primary prevention in high-risk individuals, in whom the strategy is cost-effective and the benefits exceed the risks. Whether primary prevention is beneficial in individuals at low or moderate risk is not certain. Therefore, the prescription of statins for primary prevention should be individualized on the basis of clinical judgment, particularly for low-risk individuals. In appropriately selected individuals, statins should also be used for primary prevention of ischaemic stroke and transient ischaemic attack. © 2013 Macmillan Publishers Limited. All rights reserved.

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