Zagreb, Croatia
Zagreb, Croatia

The University of Zagreb is the largest Croatian university and the oldest continuously operating university in the area covering Central Europe south of Vienna and all of Southeastern Europe. As of 2011, University of Zagreb is ranked among the 500 Best Universities of the world by the Shanghai Academic Ranking of World Universities. Wikipedia.

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Hafner A.,University of Zagreb | Lovric J.,University of Zagreb | Lako G.P.,Agency for Medicinal Products and Medical Devices | Pepic I.,University of Zagreb
International Journal of Nanomedicine | Year: 2014

The application of nanotechnology in areas of drug delivery and therapy (ie, nanotherapeutics) is envisioned to have a great impact on public health. The ability of nanotherapeutics to provide targeted drug delivery, improve drug solubility, extend drug half- life, improve a drug's therapeutic index, and reduce a drug's immunogenicity has resulted in the potential to revolutionize the treatment of many diseases. In this paper, we review the liposome-, nanocrystal-virosome polymer therapeutic-, nanoemulsion-, and nanoparticle- based approaches to nanotherapeutics, which represent the most successful and commercialized categories within the field of nanomedicine. We discuss the regulatory pathway and initiatives endeavoring to ensure the safe and timely clinical translation of emerging nanotherapeutics and realization of health care benefits. Emerging trends are expected to confirm that this nano-concept can exert a macro-impact on patient benefits, treatment options, and the EU economy. © 2014 Hafner et al.

The present invention relates to the field of prevention and treatment of muscle atrophy. More particular, the present invention relates to a composition comprising hesperetin, (-) epicatechin and myricetin. The present invention further relates to the use of said composition as inhibitor and stimulator for signaling pathways.

Duic N.,University of Zagreb | Rosen M.A.,University of Ontario Institute of Technology
Energy Conversion and Management | Year: 2014

The 8th Conference on Sustainable Development of Energy, Water and Environment Systems (SDEWES) was held in 2013 and was attended by 550 experts from 62 countries representing six continents. The conference was focused on the improvement and dissemination of knowledge on methods, policies and technologies for increasing the sustainability of development by de-coupling growth from natural resources and replacing or enhancing them with a knowledge-based economy. The conference covered the economic, environmental and social pillars of sustainability, along with methods for assessing and measuring the sustainability of development, regarding energy, transport, water, environment and food production systems and their many combinations. The special issue of Energy Conversion and Management includes selected contributions from the 8th SDEWES Conference and aims to provide energy researchers and experts information about future developments in this area.

Koscec A.,Institute for Medical Research and Occupational Health | Koscec A.,University of Zagreb | Radosevic-Vidacek B.,Institute for Medical Research and Occupational Health | Bakotic M.,Institute for Medical Research and Occupational Health
Chronobiology International | Year: 2014

School system in which classes are scheduled 1 week in the morning and the other in the afternoon, and in which students rotate schedule every week, fosters sleep irregularity. In this study, we examined morningness-eveningness of adolescents who were involved in such schedule of school time and explored relationship between their circadian preferences and sleep characteristics. A large sample of 2287 students between the ages 11 and 18 years (52% girls) from 24 schools in Croatia was studied. The School Sleep Habits Survey was modified to enable differentiation of sleep patterns between the two school schedules and weekends. Two measures of ME were used: the Morningness-Eveningness Scale for Children (MESC) and mid-sleep time on weekends (MSFsc). Both measures showed a shift to eveningness starting between the ages 12 and 13 (MESC), or 13 and 14 (MSFsc). However, MESC demonstrated a plateau in the shift in older adolescent whereas MSFsc indicated further progress of phase delay. Significant differences in sleep timing and duration were found between three chronotype groups (Morning, Intermediate, and Evening). Generally, Evening types went to bed and woke up the latest in all situations. Their sleep duration was the shortest on school week with morning schedule. On weekends Morning types slept shorter than other two chronotype groups. On school week with afternoon schedule all chronotype groups slept close to the recommended 9 h. All three chronotype groups delayed their bedtimes and wake-up times, and extended their sleep in situations with fewer constraints on sleep timing (i.e. afternoon school schedule, and weekends versus morning school schedule). Expectedly, the evening types showed the greatest sleep irregularity. The findings of this study suggest that the Croatian school system fosters sleep irregularity, but provides more opportunity for fulfilling sleep need of all chronotype groups of adolescents. Age effects on morningness-eveningness observed in Croatian adolescent do not seem to be different from those observed in adolescents from other countries involved in a regular morning school schedule. Further studies are necessary to explore differences in the trend of shift towards eveningness found between the two measures of morningness-eveningness in this, as well as in other studies. © Informa Healthcare USA, Inc.

Cvetko Tesovic B.,University of Zagreb | Glumac B.,Smith College | Buckovic D.,University of Zagreb
Cretaceous Research | Year: 2011

The Adriatic-Dinaridic carbonate platform (ADCP) was one of the largest and relatively well preserved Mesozoic platforms in the Mediterranean region (central Tethys). The peninsula Istria, in the northwestern part of the ADCP, is built up predominantly of shallow-water carbonates of the Middle Jurassic (Dogger) to Eocene age and, to a lesser extent, of Paleogene clastic deposits (flysch and calcareous breccia). This study focuses on a Lower Cretaceous (Barremian to Albian) succession of strata at five localities in western Istria. Stratigraphic determinations are based on identification of nine microfossil assemblages (benthic foraminifera and calcareous algae Dasycladales) and on using their taxa as index fossils. The age of strata with these microfossil assemblages, however, is questionable. Most of the age uncertainties are associated with a regional emersion, which occurred on the ADCP during the Aptian or close to the Aptian-Albian transition. It is unclear what portions of the Upper Aptian and/or Lower Albian are missing along this unconformity. A stable isotope study was conducted on homogenous micritic matrix samples in an attempt to resolve some of these uncertainties. Variations in carbon isotope compositions proved useful for stratigraphic correlation between the examined successions of strata, for improving their age determination, and for relating them to other coeval successions that span an important time interval of major oceanographic changes and carbon-cycle perturbations associated with the Early Aptian oceanic anoxic event (OAE 1a). © 2010 Elsevier Ltd.

Vrcek V.,University of Zagreb | Vinkovic Vrcek I.,Institute for Medical Research and Occupational Health
International Journal of Food Science and Technology | Year: 2012

This study was undertaken (i) to optimise and validate a suitable method for multi-element determination in cereal products and (ii) to evaluate multi-element content differences in commercially available conventional vs. organic wheat flours. Presented ICP-MS method is simple and accurate for the determination of eighteen elements in cereal food. Obtained results show differences in metal content between conventional and organic wheat flours and confirm that both types of production are well within the toxicological safety limits regarding the metal contents. The significant differences among conventional vs. organic wheat flours were obtained for As, Cd, Cr, Fe, Mg, Mo, Ni and V. Toxic metals (Al, As, Cd and Pb) input was higher in conventional compared with organic wheat flours. However, further and long-term research is needed to clearly underline the effects of organic agricultural practice on the quality of food products. © 2012 The Authors. International Journal of Food Science and Technology © 2012 Institute of Food Science and Technology.

Begovac J.,University of Zagreb
Expert Review of Anti-Infective Therapy | Year: 2010

Patterns of HIV transmission in the seven countries of southeastern Europe (Albania, Bosnia and Herzegovina, Croatia, Montenegro, former Yugoslav Republic of Macedonia, Serbia and Slovenia) indicate that men who have sex with men (MSM) bear the highest burden of HIV. In 2008, MSM represented 56% of all HIV cases reported in Serbia, and 71 and 76% in Slovenia and Croatia, respectively. In other countries the number of reported HIV cases attributed to MSM remains low, which is likely due to under reporting. HIV prevalence measured in surveys was the highest among MSM compared with other at-risk groups, ranging from 0.7% in Bosnia and Herzegovina to 6.1% in Serbia. Data on sexual behaviors and HIV testing uptake indicate an urgent need to increase coverage with prevention services. © 2010 Expert Reviews Ltd.

Roller M.,University of Zagreb | Lucic V.,University of Zagreb | Nagy I.,Hungarian Academy of Sciences | Perica T.,University of Cambridge | And 2 more authors.
Nucleic Acids Research | Year: 2013

Microbial communities represent the largest portion of the Earth's biomass. Metagenomics projects use high-throughput sequencing to survey these communities and shed light on genetic capabilities that enable microbes to inhabit every corner of the biosphere. Metagenome studies are generally based on (i) classifying and ranking functions of identified genes; and (ii) estimating the phyletic distribution of constituent microbial species. To understand microbial communities at the systems level, it is necessary to extend these studies beyond the species' boundaries and capture higher levels of metabolic complexity. We evaluated 11 metagenome samples and demonstrated that microbes inhabiting the same ecological niche share common preferences for synonymous codons, regardless of their phylogeny. By exploring concepts of translational optimization through codon usage adaptation, we demonstrated that community-wide bias in codon usage can be used as a prediction tool for lifestyle-specific genes across the entire microbial community, effectively considering microbial communities as meta-genomes. These findings set up a 'functional metagenomics' platform for the identification of genes relevant for adaptations of entire microbial communities to environments. Our results provide valuable arguments in defining the concept of microbial species through the context of their interactions within the community. © 2013 The Author(s) 2013.

Bozicevic M.S.,Croatian National Bank | Gajovic A.,Ruder Boskovic Institute | Zjakic I.,University of Zagreb
Forensic Science International | Year: 2012

This study explores the applicability of micro-Raman spectroscopy as a non-destructive technique for the analysis of color toner printed counterfeits. The main aim of the research paper was to find out whether Raman spectroscopy is a suitable method for establishing the connection between different specimens of counterfeits suspected to be printed with the same toner on the same machine. Specimens of different types of toners printed on different types of paper are analyzed by means of the micro-Raman spectroscopy system with the excitation line at 514.5. nm. For each specimen cyan, magenta and yellow toners are analyzed separately. The yellow toners displayed the most distinctive Raman spectra. The results show that micro-Raman spectroscopy can be successfully applied as a method for the analysis of color toner printed counterfeits, such as banknotes and documents, in order to establish links between more or less different specimens of counterfeits by measuring the properties of a color toner. © 2012 Elsevier Ireland Ltd.

Cilloniz C.,University of Barcelona | Civljak R.,University of Zagreb | Nicolini A.,Hospital of Sestri Levante | Torres A.,University of Barcelona
Respirology | Year: 2016

Polymicrobial aetiology in community-acquired pneumonia (CAP) is more common than previously recognized. This growing new entity can influence inflammation, host immunity and disease outcomes in CAP patients. However, the true incidence is complicated to determine and probably underestimated due mainly to many cases going undetected, particularly in the outpatient setting, as the diagnostic yield is restricted by the sensitivity of currently available microbiologic tests and the ability to get certain types of clinical specimens. The observed rate of polymicrobial cases may also lead to new antibiotic therapy considerations. In this review, we discuss the pathogenesis, microbial interactions in pneumonia, epidemiology, biomarkers and antibiotic therapy for polymicrobial CAP. © 2015 Asian Pacific Society of Respirology.

Fowkes F.G.R.,University of Edinburgh | Rudan D.,University of Edinburgh | Rudan D.,University of Zagreb | Rudan I.,University of Edinburgh | And 9 more authors.
The Lancet | Year: 2013

Background Lower extremity peripheral artery disease is the third leading cause of atherosclerotic cardiovascular morbidity, following coronary artery disease and stroke. This study provides the fi rst comparison of the prevalence of peripheral artery disease between high-income countries (HIC) and low-income or middle-income countries (LMIC), establishes the primary risk factors for peripheral artery disease in these settings, and estimates the number of people living with peripheral artery disease regionally and globally. Methods We did a systematic review of the literature on the prevalence of peripheral artery disease in which we searched for community-based studies since 1997 that defi ned peripheral artery disease as an ankle brachial index (ABI) lower than or equal to 0.90. We used epidemiological modelling to defi ne age-specifi c and sex-specifi c prevalence rates in HIC and in LMIC and combined them with UN population numbers for 2000 and 2010 to estimate the global prevalence of peripheral artery disease. Within a subset of studies, we did meta-analyses of odds ratios (ORs) associated with 15 putative risk factors for peripheral artery disease to estimate their eff ect size in HIC and LMIC. We then used the risk factors to predict peripheral artery disease numbers in eight WHO regions (three HIC and fi ve LMIC). Findings 34 studies satisfi ed the inclusion criteria, 22 from HIC and 12 from LMIC, including 112 027 participants, of which 9347 had peripheral artery disease. Sex-specifi c prevalence rates increased with age and were broadly similar in HIC and LMIC and in men and women. The prevalence in HIC at age 45-49 years was 5.28% (95% CI 3.38-8.17%) in women and 5.41% (3.41-8.49%) in men, and at age 85-89 years, it was 18.38% (11.16-28.76%) in women and 18.83% (12.03-28.25%) in men. Prevalence in men was lower in LMIC than in HIC (2.89% [2.04-4.07%] at 45-49 years and 14.94% [9.58-22.56%] at 85-89 years). In LMIC, rates were higher in women than in men, especially at younger ages (6.31% [4.86-8.15%] of women aged 45-49 years). Smoking was an important risk factor in both HIC and LMIC, with meta-OR for current smoking of 2.72 (95% CI 2.39-3.09) in HIC and 1.42 (1.25-1.62) in LMIC, followed by diabetes (1.88 [1.66-2.14] vs 1.47 [1.29-1.68]), hypertension (1.55 [1.42-1.71] vs 1.36 [1.24-1.50]), and hypercholesterolaemia (1.19 [1.07-1.33] vs 1.14 [1.03-1.25]). Globally, 202 million people were living with peripheral artery disease in 2010, 69.7% of them in LMIC, including 54.8 million in southeast Asia and 45.9 million in the western Pacifi c Region. During the preceding decade the number of individuals with peripheral artery disease increased by 28.7% in LMIC and 13.1% in HIC. Interpretation In the 21st century, peripheral artery disease has become a global problem. Governments, nongovernmental organisations, and the private sector in LMIC need to address the social and economic consequences, and assess the best strategies for optimum treatment and prevention of this disease.

Dragicevic T.,University of Aalborg | Guerrero J.M.,University of Aalborg | Vasquez J.C.,University of Aalborg | Skrlec D.,University of Zagreb
IEEE Transactions on Power Electronics | Year: 2014

DC power systems are gaining an increasing interest in renewable energy applications because of the good matching with dc output type sources such as photovoltaic (PV) systems and secondary batteries. In this paper, several distributed generators (DGs) have been merged together with a pair of batteries and loads to form an autonomous dc microgrid (MG). To overcome the control challenge associated with coordination of multiple batteries within one stand-alone MG, a double-layer hierarchical control strategy was proposed. 1) The unit-level primary control layer was established by an adaptive voltage-droop method aimed to regulate the common bus voltage and to sustain the states of charge (SOCs) of batteries close to each other during moderate replenishment. The control of every unit was expanded with unit-specific algorithm, i.e., finish-of-charging for batteries and maximum power-point tracking (MPPT) for renewable energy sources, with which a smooth online overlap was designed and 2) the supervisory control layer was designed to use the low-bandwidth communication interface between the central controller and sources in order to collect data needed for adaptive calculation of virtual resistances (VRs) as well as transit criteria for changing unit-level operating modes. A small-signal stability for the whole range of VRs. The performance of developed control was assessed through experimental results. © 1986-2012 IEEE.

Marketin T.,Helmholtz Center for Heavy Ion Research | Marketin T.,University of Zagreb | Litvinova E.,Helmholtz Center for Heavy Ion Research | Vretenar D.,University of Zagreb | Ring P.,TU Munich
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2012

An extension of time-dependent covariant density functional theory that includes particle-vibration coupling is applied to the charge-exchange channel. Spin-dipole excitation spectra are calculated an compared to available data for 90Zr and 208Pb. A significant fragmentation is found for all three angular-momentum components of the spin-dipole strength as a result of particle-vibration coupling, as well as a shift of a portion of the strength to higher energy. A high-energy tail is formed in the strength distribution that linearly decreases with energy. Using a model-independent sum rule, the corresponding neutron skin thickness is estimated and shown to be consistent with values obtained at the mean-field level. © 2011 Elsevier B.V.

Vanic Z.,University of Zagreb | Planinsek O.,University of Ljubljana | Skalko-Basnet N.,University of Tromsø | Tho I.,University of Tromsø
European Journal of Pharmaceutics and Biopharmaceutics | Year: 2014

The purpose of this study was to develop a novel drug delivery system for challenging drugs with potential for scale-up manufacturing and controlled release of incorporated drug. Pre-liposomes powder containing metronidazole, lecithin and mannitol, prepared by spray-drying, was mixed with different tableting excipients (microcrystalline cellulose, lactose monohydrate, mannitol, dibasic calcium phosphate, pregelatinized starch, pectin or chitosan) and compressed into tablets. The delivery system was characterized with respect to (i) dry powder characteristics, (ii) mechanical tablet properties and drug release, and (iii) liposomal characteristics. The pre-liposomes powder was free-flowing, and tablets of similarly high qualities as tablets made of physical mixtures were prepared with all excipients. Liposomes were formed in situ upon tablet disintegration, dissolution or erosion depending on the type of tablet excipient used. The liposomal characteristics and drug release were found to depend on the tablet excipient. The new delivery system offers a unique synergy between the ability of liposomes to encapsulate and protect drugs and increased stability provided by compressed formulations. It can be adjusted for drug administration via various routes, e.g. oral, buccal and vaginal. © 2014 Elsevier B.V. All rights reserved.

Krasznahorkay A.,Hungarian Academy of Sciences | Paar N.,University of Zagreb | Vretenar D.,University of Zagreb | Harakeh M.N.,University of Groningen
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2013

We examine a method to determine the neutron-skin thickness of nuclei using data on the charge-exchange anti-analog giant dipole resonance (AGDR). Calculations performed using the relativistic proton-neutron quasiparticle random-phase approximation (pn-RQRPA) reproduce the isotopic trend of the excitation energies of the AGDR, as well as that of the spin-flip giant dipole resonances (IVSGDR), in comparison to available data for the even-even isotopes 112-124Sn. It is shown that the excitation energies of the AGDR, obtained using a set of density-dependent effective interactions which span a range of the symmetry energy at saturation density, supplemented with the experimental values, provide a stringent constraint on value of the neutron-skin thickness. For 124Sn, in particular, we determine the value δRpn=0.21±0.05 fm. The result of the present study shows that a measurement of the excitation energy of the AGDR in (p, n) reactions using rare-isotope beams in inverse kinematics, provides a valuable method for the determination of neutron-skin thickness in exotic nuclei. © 2013 Elsevier B.V.

Ma E.,University of California at Riverside | Picek I.,University of Zagreb | Radovcic B.,University of Zagreb
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2013

We propose a new realization of the one-loop radiative model of neutrino mass generated by dark matter (scotogenic), where the particles in the loop have an additional U(1)D gauge symmetry, which may be exact or broken to Z2. This model is relevant to a number of astrophysical observations, including AMS-02 and the dark-matter distribution in dwarf galactic halos. © 2013 Elsevier B.V.

Bohinc K.,University of Ljubljana | Kovacevic D.,University of Zagreb | Pozar J.,University of Zagreb
Physical Chemistry Chemical Physics | Year: 2013

The (de)protonation equilibrium of the poly(allylammonium) cation (PAH) in an aqueous solution of various binary 1:1 electrolytes of different concentrations (0.1 ≤ c(NaX)/mol dm-3 ≤ 1.0; X = Cl -, Br-, I-, NO3 -) was investigated potentiometrically at 25 °C. The mixed and concentration apparent equilibrium deprotonation constants (Kap) were calculated from the experimentally collected data and concentration profiles of dissociated and undissociated functional groups were obtained. The standard pK value of monomers was estimated by extrapolating the pKap values determined at various concentrations of added electrolyte to the degree of dissociation α = 1. The dependence of pKap on the degree of dissociation could be well described by the two parameter model according to Mandel. The variation of with monomer dissociation degree was found to be in satisfactory agreement with the cylinder Stern model, based on the Poisson-Boltzmann (PB) equation, and a constant Stern capacitance. Generally, the derived apparent constants showed a pronounced dependence on the concentration of binary electrolytes and a weak dependence on the type of anion counterbalancing the polyion charge. The influence of the PAH chain length (polymers containing on average 150 and 700 monomers were examined) on the protonation equilibrium of PAH could not be observed. © 2013 the Owner Societies.

Suric M.,University of Zadar | Juracic M.,University of Zagreb
Geologia Croatica | Year: 2010

U-Th and14C dating, and X-ray diffraction of parts of 16 submerged speleothems taken from depths of 1.5-41.5 m from 7 submarine caves and pits along the Eastern Adriatic coast, provided insight into the sea-level fluctuations during the last 220 ka, and to the palaeogeographic changes caused by sea-level changes. Due to climate changes, palaeoenvironmental settings also varied, but not so abruptly and intensely as in the rest of Europe. As the Alps and Dinarides acted as orographic barriers, the Eastern Adriatic coast was the border region between periglacial Europe and the temperate Mediterranean region. It was also a refuge area for plant species from the north. This study showed that appropriate temperature, humidity and vegetation cover ensured favourable conditions for karstification and speleothem formation even during the Last Glacial Maximum.

Hojsak I.,Childrens Hospital Zagreb | Abdovic S.,Childrens Hospital Zagreb | Szajewska H.,Medical University of Warsaw | Krznaric Z.,University of Zagreb | Kolacek S.,Childrens Hospital Zagreb
Pediatrics | Year: 2010

OBJECTIVE: The incidence of nosocomial infections, predominantly gastrointestinal and respiratory, in children in developed countries is high, ranging from 5% to 44%. There is no effective strategy for preventing these infections. The objective of our study was to investigate the role of Lactobacillus GG (LGG) in preventing nosocomial gastrointestinal and respiratory tract infections at a pediatric hospital. METHODS: We conducted a randomized, double-blind, placebocontrolled trial of 742 hospitalized children. They were randomly allocated to receive for their hospitalization LGG at a dose of 109 colonyforming units in 100 mL of a fermented milk product (LGG group, n = 376) or placebo that was the same postpasteurized fermented milk product without LGG (placebo group, n = 366). RESULTS: In the LGG group, compared with the placebo group, we found a significantly reduced risk for gastrointestinal infections (relative risk [RR]: 0.40 [95% confidence interval (CI): 0.25- 0.70]; number needed to treat: 15 [95% CI: 9-34)], respiratory tract infections (RR: 0.38 [95% CI: 0.18-0.85]; number needed to treat: 30 [95% CI: 16-159]), vomiting episodes (RR: 0.5 [95% CI: 0.3-0.9]), diarrheal episodes (RR: 0.24 [95% CI: 0.10-0.50]), episodes of gastrointestinal infections that lasted >2 days (RR: 0.40 [95% CI: 0.25-0.70]), and episodes of respiratory tract infections that lasted >3 days (RR: 0.4 [95% CI: 0.2-0.9]). Groups did not differ in hospitalization duration (P = .1). CONCLUSIONS: LGG administration can be recommended as a valid measure for decreasing the risk for nosocomial gastrointestinal and respiratory tract infections in pediatric facilities. Copyright © 2010 by the American Academy of Pediatrics.

Supek F.,Ruder Boskovic Institute | Skunca N.,Ruder Boskovic Institute | Repar J.,Ruder Boskovic Institute | Vlahovicek K.,University of Zagreb | And 2 more authors.
PLoS Genetics | Year: 2010

Codon usage bias in prokaryotic genomes is largely a consequence of background substitution patterns in DNA, but highly expressed genes may show a preference towards codons that enable more efficient and/or accurate translation. We introduce a novel approach based on supervised machine learning that detects effects of translational selection on genes, while controlling for local variation in nucleotide substitution patterns represented as sequence composition of intergenic DNA. A cornerstone of our method is a Random Forest classifier that outperformed previous distance measure-based approaches, such as the codon adaptation index, in the task of discerning the (highly expressed) ribosomal protein genes by their codon frequencies. Unlike previous reports, we show evidence that translational selection in prokaryotes is practically universal: in 460 of 461 examined microbial genomes, we find that a subset of genes shows a higher codon usage similarity to the ribosomal proteins than would be expected from the local sequence composition. These genes constitute a substantial part of the genome-between 5% and 33%, depending on genome size-while also exhibiting higher experimentally measured mRNA abundances and tending toward codons that match tRNA anticodons by canonical base pairing. Certain gene functional categories are generally enriched with, or depleted of codon-optimized genes, the trends of enrichment/depletion being conserved between Archaea and Bacteria. Prominent exceptions from these trends might indicate genes with alternative physiological roles; we speculate on specific examples related to detoxication of oxygen radicals and ammonia and to possible misannotations of asparaginyl-tRNA synthetases. Since the presence of codon optimizations on genes is a valid proxy for expression levels in fully sequenced genomes, we provide an example of an "adaptome" by highlighting gene functions with expression levels elevated specifically in thermophilic Bacteria and Archaea. © 2010 Supek et al.

Puksec T.,University of Zagreb | Mathiesen B.V.,University of Aalborg | Novosel T.,University of Zagreb | Duic N.,University of Zagreb
Energy | Year: 2014

In the light of European energy-climate package and its measures for increasing security of supply, decreasing the impact on environment and stimulating sustainability, Croatia as a new EU (European Union) member state needs to reconsider and develop new energy policy towards energy efficiency and renewable energy sources. Croatian long-term energy demand and its effect on the future national GHG (greenhouse gas) emissions are analysed in this paper. For that purpose the NeD model was constructed (National energy demand model). The model is comprised out of six modules, each representing one sector: industry, transport, households, services, agriculture and construction. The model is based on bottom up approach. The analysis has shown that energy policy measures, identified through this paper, can potentially achieve energy savings up to 157PJ in the year 2050, which presents a 40% decrease to referent (frozen efficiency) scenario. Results obtained in this paper were also compared to the Croatian National Energy Strategy for the years 2020 and 2030. It was shown that if already implemented policies were properly taken into account the actual final energy demand for the year 2030 would be 43% lower than projected by the Croatian National Energy Strategy. © 2014 Elsevier Ltd.

Segvic Klaric M.,University of Zagreb | Rasic D.,Institute for Medical Research and Occupational Health | Peraica M.,Institute for Medical Research and Occupational Health
Toxins | Year: 2013

Ochratoxin A (OTA) is a nephrotoxic mycotoxin with carcinogenic properties. Its presence was detected in various foodstuffs all over the world but with significantly higher frequency and concentrations in areas with endemic nephropathy (EN). Even though food is often contaminated with more than one mycotoxin, earlier studies focused on the occurrence and toxicology of only OTA. Only a limited number of surveys showed that OTA co-occurs in food with mycotoxins (citrinin-CIT, penicilic acid, fumonisin B1-FB1, aflatoxins-AF) which exert nephrotoxic, carcinogenic or carcinogen-promoting activity. This review summarises the findings on OTA and its co-occurrence with the mentioned mycotoxins in food as well as experimental data on their combined toxicity. Most of the tested mycotoxin mixtures involving OTA produced additive or synergistic effects in experimental models suggesting that these combinations represent a significant health hazard. Special attention should be given to mixtures that include carcinogenic and cancer-promoting mycotoxins. © 2013 by the authors; licensee MDPI, Basel, Switzerland.

Ridjan I.,University of Aalborg | Mathiesen B.V.,University of Aalborg | Connolly D.,University of Aalborg | Duic N.,University of Zagreb
Energy | Year: 2013

While all other sectors had significant renewable energy penetrations, transport is still heavily dependent on oil displaying rapid growth in the last decades. There is no easy renewable solution to meet transport sector demand due to the wide variety of modes and needs in the sector. Nowadays, biofuels along with electricity are proposed as one of the main options for replacing fossil fuels in the transport sector. The main reasons for avoiding the direct usage of biomass, i.e. producing biomass derived fuels, are land use shortages, limited biomass availability, interference with food supplies, and other impacts on the environment and biosphere. Hence, it is essential to make a detailed analysis of this sector in order to match the demand and to meet the criteria of a 100% renewable energy system in 2050. The purpose of this article is to identify potential pathways for producing synthetic fuels, with a specific focus on solid oxide electrolyser cells (SOEC) combined with the recycling of CO2. © 2013 Elsevier Ltd.

Markovic G.,University of Zagreb | Jaric S.,University of Delaware
International Journal of Sports Medicine | Year: 2011

We examined the effects of jump training with negative (30% of the subject's body weight (BW)) vs. positive loading (+30% BW) on the mechanical behaviour of leg extensor muscles. 32 men were divided into control (CG), negative loading (NLG), or positive loading training group (PLG). Both training groups performed maximal effort countermovement jumps (CMJ) over a 7-week training period. The impact of training on the mechanical behaviour of leg extensor muscles was assessed through CMJ performed with external loads ranging from 30% BW to +30% BW. Both training groups showed significant (P0.013) increase in BW CMJ height (NLG: 9%, effect size (ES)=0.85, vs. PLG: 3.4%, ES=0.31), peak jumping velocity (vpeak; NLG: 4.1%; ES=0.80, P=0.011, vs. PLG: 1.4%, ES=0.24; P=0.017), and depth of the countermovement (h ecc; NLG: 20%; ES=1.64, P=0.004, vs. PLG: 11.4%; ES=0.86, P=0.015). Although the increase in both the vpeak and hecc were expected to reduce the recorded ground reaction force, the indices of force- and power-production characteristics of CMJ remained unchanged. Finally, NLG (but not PLG) suggested load-specific improvement in the movement kinematic and kinetic patterns. Overall, the observed results revealed a rather novel finding regarding the effectiveness of negative loading in enhancing CMJ performance which could be of potential importance for further development of routine training protocols. Although the involved biomechanical and neuromuscular mechanisms need further exploration, the improved performance could be partly based on an altered jumping pattern that utilizes an enhanced ability of leg extensors to provide kinetic and power output during the concentric jump phase. © 2010 Georg Thieme Verlag KG Stuttgart · New York.

Reiner Z.,University of Zagreb | Tedeschi-Reiner E.,University of Zagreb
Croatian Medical Journal | Year: 2013

Aim To determine the prevalence and types of persistent dyslipidemia in patients treated with different statins to reduce cardiovascular disease (CVD) risk, as well as to determine the proportion of high risk patients who did not reach the lipid target values and assess cardiologists' further treatment advice for these patients. Methods This cross-sectional, observational study recruited 1849 outpatients from all parts of Croatia between January and September 2011 (44.6% women), 19 to 90 years old (average age 63.13) treated with statins for at least 6 months. We analyzed how the potency and type of lipidlowering treatment were correlated with CVD risk level and achieving treatment goals according to 2007 Joint European Guidelines on CVD prevention. Results Most patients (81.3%) were at high risk for CVD. The most frequently used statin was atorvastatin (42.8%), followed by simvastatin (27.6%) and rosuvastatin (22.8%). Only 35.5% patients achieved low density lipoproteincholesterol treatment target. Patients treated with more potent statins had better results. A total of 22.3% of patients had high density lipoprotein-cholesterol below 1.0 mmol/L ( ̃ 40 mg/dL) for men and below 1.2 ( ̃ 45 mg/dL) for women and 46.4% had triglycerides above 1.7 mmol/L ( ̃ 150 mg/dL) but there were no significant differences between statins in improving these parameters. Most of the patients on more potent statins were not advised by their cardiologists to change the type or dosage of statin, which was more common in patients on less potent statins. Conclusion A considerable number of patients treated with statins did not achieve the treatment goal values. The results were better in patients treated with more potent statins and cardiologists advised them much less frequently to change the type and dosage of statin. There is a need for more intensive treatment, especially for high-risk patients. This could be accomplished by optimizing patients' adherence, using more potent statins, titrating current statin therapy to higher doses, or using a combined lipid-lowering treatment.

Schneider D.R.,University of Zagreb | Kirac M.,United Nations Development Programme Croatia | Hublin A.,Ekonerg Energy and Environmental Protection Institute
Energy | Year: 2012

Many of the modern practices in waste management at the same time represent means of reduction of greenhouse gas (GHG) emissions. The main focus in this paper is given to the measures for recovering energy from municipal solid waste (MSW): Utilization of landfill gas for electricity production, Utilization of refuse derived fuel (RDF) in cement industry, Thermal treatment (Incineration) of MSW, Mechanical-biological treatment, and to one measure without energy recovery - Landfill gas flaring, for all of which it was found that could generate substantial GHG emission savings.The economic side of the implementation of these measures, considering the GHG emission reduction, is analysed in order to determine the priority between them. With respect to the cost-effectiveness, marginal costs (expressed as € per ton of reduced or avoided CO2eq) are calculated for all the measures.It was determined that around 1 million tons of CO2 can be avoided in 2020, which is 2.7% of projected GHG emissions in Croatia, while the energy that could be recovered from waste is 8.3 PJ in 2020, which represents about 3% of the total final energy consumption in 2008. The measures Utilization of landfill gas for electricity production and Landfill gas flaring showed the greatest economic benefit. © 2012 Elsevier Ltd.

Eeg J.O.,University of Oslo | Kumericki K.,University of Zagreb
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2010

We consider the Isgur-Wise function ξ(ω) within a new modified version of a heavy-light chiral quark model. While early versions of such models gave an absolute value of the slope that was too small, namely ξ′(1)-0.4 to -0.3, we show how extended version(s) may lead to values around -1, in better agreement with recent measurements. This is obtained by introducing a new mass parameter in the heavy-quark propagator. We also shortly comment on the consequences for the decay modes B→DD̄. © 2010 The American Physical Society.

Despoja V.,University of Zagreb | Despoja V.,Donostia International Physics Center
Physical Review B - Condensed Matter and Materials Physics | Year: 2014

We have benchmarked long range behavior of seven different van der Waals functionals comparing them with our ACF-RPA correlation calculations for graphene on a Ag(111) system. Correlation given by the second version of van der Waals density functional vdW-DF2 agrees remarkably well with our random phase approximation (RPA) calculation in the long range region. In the intermediate and shorter range regions combining vdW-DF2 correlation with proper exchange functional becomes important. We compared the results of the van der Waals functionals in this region to the previous RPA calculations and to some extent to experimental observations, and calculated that the combined vdW-DF2(C09x) or rev-vdW-DF2 functionals show satisfactory behavior. © 2014 American Physical Society.

PukSec T.,University of Zagreb | Vad Mathiesen B.,University of Aalborg | Duic N.,University of Zagreb
Applied Energy | Year: 2013

Households represent one of the most interesting sectors, when analyzing Croatia's energy balance. It makes up one of the largest energy consumers with around 75. PJ per year, which is almost 29% of Croatia's final energy demand. Considering this consumption, implementing various mechanisms, which would lead to improvements in energy efficiency of this sector, seems relevant. In order to plan future energy systems, important would be to know future possibilities and needs regarding energy demand of different sectors. Through this paper, long term energy demand projections of Croatian households sector will be shown. Focus of the paper will be on various mechanisms influencing future energy demand scenarios. Important would be to quantify this influence, whether positive or negative, and see which mechanisms would be the most significant. Energy demand projections in this paper are based upon bottom-up approach model which combines and processes a large number of input data. The model will be compared to Croatian National Energy Strategy and certain differences and conclusions will be presented. One of the major conclusions shown in this paper is significant possibilities for energy efficiency improvements and lower energy demand in the future, based on careful and rational energy planning. Different financial, legal and technological mechanisms can lead to significant savings in the households sector which leads to lower GHG emissions and lower Croatian dependence on foreign fossil fuels. © 2012 Elsevier Ltd.

Mroczko-Wasowicz A.,National Yang Ming University | Nikolic D.,Ernst Strüngmann Institute (ESI) for Neuroscience | Nikolic D.,Frankfurt Institute for Advanced Studies | Nikolic D.,Max Planck Institute for Brain Research | Nikolic D.,University of Zagreb
Frontiers in Human Neuroscience | Year: 2014

Currently, little is known about how synesthesia develops and which aspects of synesthesia can be acquired through a learning process. We review the increasing evidence for the role of semantic representations in the induction of synesthesia, and argue for the thesis that synesthetic abilities are developed and modified by semantic mechanisms. That is, in certain people semantic mechanisms associate concepts with perception-like experiences-and this association occurs in an extraordinary way. This phenomenon can be referred to as "higher" synesthesia or ideasthesia. The present analysis suggests that synesthesia develops during childhood and is being enriched further throughout the synesthetes' lifetime; for example, the already existing concurrents may be adopted by novel inducers or new concurrents may be formed. For a deeper understanding of the origin and nature of synesthesia we propose to focus future research on two aspects: (i) the similarities between synesthesia and ordinary phenomenal experiences based on concepts; and (ii) the tight entanglement of perception, cognition and the conceptualization of the world. Importantly, an explanation of how biological systems get to generate experiences, synesthetic or not, may have to involve an explanation of how semantic networks are formed in general and what their role is in the ability to be aware of the surrounding world. © 2014 Mroczko-Wa sowicz and Nikolíc.

Petricevic N.,University of Zagreb | Celebic A.,University of Zagreb | Rener-Sitar K.,University of Ljubljana
Gerodontology | Year: 2012

Background: Clinical studies have mainly been focused on oral health-related quality-of-life (OHRQoL) outcomes of removable dentures. Objective: To evaluate therapy of elderly patients with implant-supported fixed partial dentures (IFPD) and tooth-supported fixed partial dentures (FPD) in the posterior dental regions. Patients and methods: The OHIP49 was used to measure OHRQoL in 64 patients with IFPD and 38 patients with FPD, before, 3 weeks and 3 years after rehabilitation. A control group (CG) consisted of 62 individuals. Results: The Oral Health Impact Profile questionnaire (OHIP) follow-up scores of the patients with FPD and the patients with IFPD were significantly smaller in comparison with the baseline scores (p < 0.01). The OHIP scores were further reduced at the 3-year follow-up. The patients with IFPD had significantly higher scores than the patients with FPD and the CG at the baseline and at the follow-ups. In the patients with FPD, both age groups (≤60 and >60) showed equal improvement of the OHRQoL. In the IFPD group, patients older than 60 years showed better improvement (p < 0.05). There were no significant differences dependent on gender and antagonistic teeth (p > 0.05). Conclusion: The FPD and the IFPD treatment showed significant improvement of OHRQoL. The FPD treatment improved OHRQoL equally in both age groups, while the IFPD treatment improved OHRQoL better in older patients. © 2011 The Gerodontology Society and John Wiley & Sons A/S.

Markovic M.,Institute for Medical Research and Occupational Health | Judas N.,University of Zagreb | Sabolovic J.,Institute for Medical Research and Occupational Health
Inorganic Chemistry | Year: 2011

Heating of polycrystalline cis aquabis(Lvalinato) copper(II) at 90 °C resulted in a dehydrated powder. Recrystallization from aqueous solution of the obtained product yielded anhydrous trans bis(L-valinato)copper(II). The X-ray crystal and molecular structures of trans bis(L-valinato)copper- (II) and cis aquabis(L-valinato)copper(II) are presented. Molecular modeling calculations were attempted to resolve factors that influenced the isomerization and crystallization of either the aqua cis- or the anhydrous trans-isomer. Conformational analyses of trans- and cis-isomers were completed in vacuo and in crystal by molecular mechanics, and in aqueous solution by molecular dynamics (MD) simulations using the same force field. Although the conformers with trans-configuration are the most stable in vacuo, those with cis-configuration form more favorable intermolecular interactions. Consequently, both cis- and trans-isomers are predicted to be present in aqueous solution. According to the crystal structure simulations and predictions, cis-isomer requires water molecules to form energetically more stable crystal packings than trans-isomer. The MD modeling of the self-assembly of 16 bis(L-valinato)copper(II) complexes in aqueous solution for the first time predicted the crystallization nucleus formation to proceed from monomers to oligomers by Cu-to-Ocarboxylato and/ orN-H 3 3Ocarboxylato weak bonds; these oligomers then bind together via water molecules until they acquire the right positions for noncovalent bonding like in the experimental crystal structures. Fifty-nanosecond MD simulations accomplished for a system consisting of equal numbers of complexes and water molecules at 298 and 370 K suggested complete cis-to-trans transformation at the higher temperature. Prevalence of either cis- or trans-conformers in water upon dissolvation may explain the crystallization results. © 2011 American Chemical Society.

Polak P.,Harvard University | Polak P.,The Broad Institute of MIT and Harvard | Karlic R.,University of Zagreb | Koren A.,The Broad Institute of MIT and Harvard | And 11 more authors.
Nature | Year: 2015

Cancer is a disease potentiated by mutations in somatic cells. Cancer mutations are not distributed uniformly along the human genome. Instead, different human genomic regions vary by up to fivefold in the local density of cancer somatic mutations, posing a fundamental problem for statistical methods used in cancer genomics. Epigenomic organization has been proposed as a major determinant of the cancer mutational landscape. However, both somatic mutagenesis and epigenomic features are highly cell-type-specific. We investigated the distribution of mutations in multiple independent samples of diverse cancer types and compared them to cell-type-specific epigenomic features. Here we show that chromatin accessibility and modification, together with replication timing, explain up to 86% of the variance in mutation rates along cancer genomes. The best predictors of local somatic mutation density are epigenomic features derived from the most likely cell type of origin of the corresponding malignancy. Moreover, we find that cell-of-origin chromatin features are much stronger determinants of cancer mutation profiles than chromatin features of matched cancer cell lines. Furthermore, we show that the cell type of origin of a cancer can be accurately determined based on the distribution of mutations along its genome. Thus, the DNA sequence of a cancer genome encompasses a wealth of information about the identity and epigenomic features of its cell of origin. © 2015 Macmillan Publishers Limited.

Pecina-Slaus N.,University of Zagreb
Cancer Cell International | Year: 2015

The development of new approaches based on wide profiling methods in studying biological and medical systems is bringing large amounts of data on a daily basis. The causes of complex diseases have been directed to the genome examination bringing formidable knowledge. We can study genome, but also proteome, exome, transcriptome, epigenome, metabolome, and newcomers too such as microbiome, connectome and exposome. The title of this editorial is paraphrasing the famous saying of Victor Schlichter from Buenos Aires children hospital in Argentina who said "How unfair! Only one health, and so many diseases". Today there is indeed a whole lot of omics. We think that we are lucky to have all the omics possible, but we also wanted to stress the importance of future holistic approach in integrating the knowledge omics has rewarded us. © 2015 Pecina-Slaus and Pecina.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SPA.2013.2.3-01 | Award Amount: 2.88M | Year: 2013

MISW (Mitigation of space weather threats to GNSS services) will tackle the research challenges associated with GNSS (Global Navigation Satellite System) and Space Weather to bring practical solutions right into the forefront of European Industry. Space Weather can affect many modern technologies that we take for granted. One of the most common technologies found across many systems today is navigation and timing provided by the Global Navigation Satellite System (GNSS). The main users of GNSS positioning are reliant on the inherent accuracy that the system can provide but this is not adequate for all applications. Aviation has its own augmentation solution called a Satellite Based Augmentation System (SBAS) and the European version is called EGNOS (European Geostationary Navigation Overlay Service). These systems gather additional information that allows some mitigation of Space Weather Events. However, they are not yet able to work in the most challenging regions and as a consequence Space Weather disturbances to the ionised upper atmosphere (ionosphere) will cause navigation errors that remain uncompensated. MISW will research, develop and apply new solutions to compensate for ionospheric effects on GNSS. Measurements of actual extreme events will allow realistic estimates of the ionospheric delays and errors caused by scintillation. MISW will include the development of new mapping techniques to compensate for ionospheric delay and both system-level and receiver-level solutions to scintillation events. The MISW consortium of leading industry, academia and research organisations will deliver the foundations for the next generation SBAS systems that can be extended across Europe and into Africa, ensuring reliable GNSS services over many decades ahead.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2007.3.7 | Award Amount: 3.37M | Year: 2008

A key socio-economic challenge for Europe is: how to deal with a climate change, while meeting rapidly increasing demand for energy and ensuring security of supply? Wind energy can be a significant part of the answer. The new frontier of the wind industry is large-scale offshore wind farms. While promising, considerable research and development tasks remain to be carried out before it reaches its full potential in terms of the efficient, stable, safe, predictable and controllable supply of energy. Closed loop control of wind power installations has historically been decentralized and a collection of wind turbines in farms is a highly complex system with interdependencies through the shared resource, the wind. Wind turbines are affected by the wind but they also changes the wind field within the farm through the control. To address objectives related to cost, quality of power and mechanical loads, models and control paradigms must be developed that allow wind resource allocation to individual turbines. Inspired by the industrial case of complex large-scale distributed offshore wind farms, the Aeolus project will research and develop models that allow real-time predictions of flows and incorporate measurements from a set of spatially distributed sensor devices. In Aeolus we will use the flow information as a basis for new control paradigms, centralized and distributed that acknowledges the uncertainty in the modelling and dynamically manages the flow resource in order to optimise specific control objectives. The model and control principles are used for control of a wind power farm to increase energy quality and reduce the fatigue loads. The usefulness of our techniques will be validated on a case study and by physical experiments on a scaled wind power farm.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: ENV.2007. | Award Amount: 1.84M | Year: 2008

Historic structures are often of extraordinary architecture, design or material. The conservation of such structures for next European generations is one of the main future tasks. To conserve historic structures it is more and more required to understand the deterioration processes mainly caused by the environment. In certain cases continuous monitoring systems have been installed to obtain information about the deterioration processes. However, most of these monitoring systems were just weather or air pollution data acquisition systems and use only basic models for data analysis. The real influence of the environment to the structure or the structural material is often unaccounted for. That means that the structural resistance is just calculated from the measurements and not determined by sufficient sensors. Another aspect is the fact that most monitoring systems require cabling, which is neither aesthetically appealing nor in some cases applicable due to the needed fastening techniques. The proposed project aims at the development of competitive tools for practitioners which goes beyond the mere accumulation of data. Smart monitoring systems using wireless sensor networks, new miniature sensor technologies (e.g. MEMS) for minimally invasive installation as well as smart data processing will be developed. It will provide help in the sense of warnings (e.g. increase of damaging factors) and recommendations for action (e.g. ventilation or heating on/off, etc.) using data fusion and interpretation that is implemented within the monitoring system. The development will consist of small smart wireless and robust sensors and networks, with sensors for monitoring of e.g. temperature, humidity, air velocity, strain and crack opening, acoustic emissions, vibration, inclination, chemical attack, ambient and UV light, with built-in deterioration and material models, data pre-processing, and alarm functions to inform responsible persons about changes of the object status. Comparative tests will be conducted to validate the models as well as the monitoring data from several case studies. The results of the project will be summarized in a toolbox and a guideline, which will be disseminated at special trainings organized for restorers, owner of cultural heritage and public authorities.

Agency: Cordis | Branch: H2020 | Program: CSA | Phase: REFLECTIVE-11-2015 | Award Amount: 1.90M | Year: 2016

Traditional valorisation approaches focus on linear processes: from academia to society. In order to bring valorisation to a higher level, all relevant actors need to cooperate in an equal setting: co-creation. Co-creation transcends boundaries, but it does not happen naturally. Therefore, the ACCOMPLISSH consortium, consisting of 14 universities from 12 countries (representing all the sub disciplines in SSH), will actively involve the other partners from the so called Quadruple Helix (industry, governments and societal partners) within the project. The project has chosen an Open Innovation approach. The ACCOMPLISSH project (Accelerate co-creation by setting up a multi-actor platform for impact from Social Sciences and Humanities) will create a platform for dialogue where not only universities are involved. The dialogue platform is organised in such a way that academia, industry, governments and societal partners equally contribute in identifying barriers and enablers of co-creation. The results from both practice and the theory of co-creation form the basis of the valorisation concept and will be tested in the project in a quadruple helix setting. This concept will be tested and developed in such a way that it is transferable, scalable and customized for academia, industry, governments and societal partners in the whole of Europe. The impact profile of SSH research could be far stronger and more visible than it currently is. There are significant barriers to the valorisation of SSH research which still need to be understood in detail. In order to push the envelope within universities, we acknowledge that next to SSH researchers, the research support officers are key players in valorisation of SSH research. The project will identify all barriers and enablers of co-creation in order to develop an innovative valorisation concept, which will foster knowledge exchange within the quadruple helix and strengthens the position of SSH research.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: REFLECTIVE-7-2014 | Award Amount: 3.99M | Year: 2015

INCEPTION realises innovation in 3D modelling of cultural heritage through an inclusive approach for time-dynamic 3D reconstruction of artefacts, built and social environments. It enriches the European identity through understanding of how European cultural heritage continuously evolves over long periods of time. INCEPTIONs Inclusive approach comprises: time dynamics of 3D reconstruction (forever); addresses scientists, engineers, authorities and citizens (for everybody); and provides methods and tools applicable across Europe (from everywhere). INCEPTION solves the shortcomings of state-of-the-art 3D reconstruction by significantly enhancing the functionalities, capabilities and cost-effectiveness of instruments and deployment procedures for 3D laser survey, data acquisition and processing. It solves the accuracy and efficiency of 3D capturing by integrating Geospatial Information, Global and Indoor Positioning Systems (GIS, GPS, IPS) both through hardware interfaces as well as software algorithms. INCEPTION methods and tools will result in 3D models that are easily accessible for all user groups and interoperable for use by different hardware and software. It develops an open-standard Semantic Web platform for Building Information Models for Cultural Heritage (HBIM) to be implemented in user-friendly Augmented Reality (VR and AR) operable on mobile devices. INCEPTION collaborative research and demonstration involves all disciplines (both social and technical sciences), technologies and sectors essential for creation and use of 3D models of cultural heritage. SMEs are the thrust of INCEPTION consortium that will bring the innovation into creative industries of design, manufacturing and ICT. The Consortium is fully supported by a Stakeholder Panel that represents an international organisation (UNESCO), European and national public institutions, and NGOs in all fields of cultural heritage.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.5.1 | Award Amount: 8.81M | Year: 2013

Independent living of senior citizens is one of the main challenges linked to the ageing population, due to the impact on: (a) the life of the elderly people, (b) the national health systems, (c) the insurance companies, (d) the relatives and (e) the care-givers. Senior citizens may suffer from a number of diseases, including the decline in cardiopulmonary conditions, weaker muscle functions and a declined neuromuscular control of the movements, which result in a higher risk of fall and a higher vulnerability for cardiovascular and pulmonary diseases. With respect to cognitive functions, senior citizens may suffer from a decline of memory function, less ability to orientate and a declined ability to cope with complex situations. Mild dementia is another disease affecting this population, which requires either the institutionalization or the constant support from care-givers.eWALL will be an affordable, easy-to-install prefabricated wall that can be mounted on an existing wall and includes, into the background, all the ICT technology needed to enable a number of services for the senior citizen to cover the major ontologies of Active and Healthy Ageing. The project will carry out high-risk and multi-disciplinary research and will have a large-scale demonstrator exercise for validating the concept with solid clinical evidence. This will include both technical-, user- and legal-evaluation, to measure with advanced tools and methodologies the impact on the QoL. The eWALL system will extend the state-of-the-art of Assistive Platforms and will significantly increase the independent living of seniors. The project will also perform socio-economic studies to deliver recommendations for the health sector that will result in mid- and long-term benefits for the sustainability of national health systems.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP-2007-2.3-1 | Award Amount: 11.09M | Year: 2008

The main driving idea of the project is the creation of conceptually new type of scaffolds able to be manipulated in situ by means of magnetic forces. This approach is expected to generate scaffolds with such characteristics as multiple use and possibly multipurpose delivery in order to repair large bone defects and ostheocondral lesions in the articular surface of the skeletal system. The major limitations of the scaffolds for bone and cartilage regeneration nowadays available in the market are related to the difficulties in controlling cell differentiation and angiogenesis processes and to obtain stable scaffold implantation in the pathological site. . . Several attempts have been performed over the last years in order to provide scaffolds for tissue engineering, but nowadays there is no way to grant that tissue regeneration take place in the pathological site. The provision in vivo of the scaffold with staminal cells or /and growth factors in order to drive the tissue differentiation process and parallel angiogenesis represents nowadays one of most challenging requests [Ref. Nanomedicine roadmap]. The Consortium aims to elaborate, investigate and fabricate new kind of scaffolds magnetic scaffolds (MagS) - characterized by strongly enhanced control and efficiency of the tissue regeneration and angiogenic processes. The magnetic moment of the scaffolds enables them with a fascinating possibility of being continuously controlled and reloaded from external supervising center with all needed scaffold materials and various active factors (AF). Such a magnetic scaffold can be imagined as a fixed station that offers a long-living assistance to the tissue engineering, providing thus a unique possibility to adjust the scaffold activity to the personal needs of the patient.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: ENV.2007. | Award Amount: 2.60M | Year: 2008

The proposed project will develop a method for scaling down the analysis of policy impacts on multifunctional land uses and on the economic activities. This method will rely on micro-simulation and multi-agents models, designed and validated at municipality level using input from stakeholders. The models will address the structural evolution of the populations (appearance, disappearance and change of agents) depending on the local conditions for applying the structural policies on a set of municipality case studies. We shall consider policies related to use of Structural Funds (SFs), Cohesion Fund (CF), Preaccession funds (PAFs) and EAFRD (respectively CAP). This project will include the following actions: - Review the EU structural policies, identify driving forces at EU, national and regional levels for multifunctional land use activities and provide baselines for the design of national and regional scenarios on multifunctional land use activities. - Interaction with stakeholders: pre-model engagement with stakeholders in terms of scenario design and formulating agent decision rules for agent-based models, on-model engagement with stakeholders mirroring agent-based models, and post-model engagement with stakeholders in terms of assessing model outputs. - Design and develop micro-simulation and multi-agents models, of local dynamics and of the impact of European structural policies at the municipality level. - Build a mapping between available data on municipalities and prototypical, contrasted evolutions of micro-simulation and agent based models. This will allow us to aggregate the results provided by these models at a regional level, on a set of regional case studies, and to compare these results with existing models at regional scale. - Investigate the potential of the approach to design a method that enhances the scope of Strategic Environmental Assessment (SEA), Environmental Impact Assessment (EIA) and Sustainable Impact Assessment (SIA).

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.3.3 | Award Amount: 6.19M | Year: 2011

Autonomous systems and unmanned aerial vehicles (UAVs), can play an important role in many applications including disaster management, and the monitoring and measurement of events, such as the volcano ash cloud of April 2010. Currently, many missions cannot be accomplished or imply a high level of risk for the people involved (pilots and drivers), as unmanned vehicles are not available or not permitted. This also applies to search and rescue missions, particularly in stormy conditions, where pilots need to risk their lives. These missions could be performed or facilitated by using autonomous helicopters with accurate positioning and the ability to land on mobile platforms such as ship decks. These applications strongly depend on the UAV reliability to react in a predictable and controllable manner in spite of perturbations, such as wind gusts.\nOn the other hand, the cooperation, coordination and traffic control of many mobile entities are relevant issues for applications such as automation of industrial warehousing, surveillance by using aerial and ground vehicles, and transportation systems.\nEC-SAFEMOBIL is devoted to the development of sufficiently accurate common motion estimation and control methods and technologies in order to reach levels of reliability and safety to facilitate unmanned vehicle deploymentin a broad range of applications. It also includes the development of a secure architecture and the middleware to support the implementation. Two different kinds of applications are included in the project:\n\n-\tVery accurate coupled motion control of two mobile entities. The technologies will be demonstrated in two challenging applications dealing with the landing on mobile platforms and launching of unmanned aerial vehicles from a manned vehicle.\n\n-\tDistributed safe reliable cooperation and coordination of many high mobility entities. The aim is to precisely control hundreds of entities efficiently and reliably and to certify developed techniques to support the exploitation of unmanned platforms in non-restricted areas. This development will be validated in two scenarios: industrial warehousing involving a large number of autonomous vehicles and surveillance also involving many mobile entities.\n\nThe new EC-SAFEMOBIL methods and the world first technology demonstrators will reinforce the position of the 5 academic and research institutions in the scientific constituency. The results will also strengthen the competitiveness of the involved companies. Three Companies will exploit the project outcome in the aeronautics and security market. One SME will improve its position in the growing industrial warehousing market. All industrial partners expect a high return on their investment.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SC5-07-2015 | Award Amount: 6.65M | Year: 2016

The project MERCES is focused on the restoration of different degraded marine habitats, with the aim of: 1) assessing the potential of different technologies and approaches; 2) quantifying the returns in terms of ecosystems services and their socio-economic impacts; 3) defining the legal-policy and governance frameworks needed to optimize the effectiveness of the different restoration approaches. Specific aims include: a) improving existing, and developing new, restoration actions of degraded marine habitats; b) increasing the adaptation of EU degraded marine habitats to global change; c) enhancing marine ecosystem resilience and services; d) conducting cost-benefit analyses for marine restoration measures; e) creating new industrial targets and opportunities. To achieve these objectives MERCES created a multi-disciplinary consortium with skills in marine ecology, restoration, law, policy and governance, socio-economics, knowledge transfer, dissemination and communication. MERCES will start from the inventory of EU degraded marine habitats (WP1), conduct pilot restoration experiments (WP2, WP3, WP4), assess the effects of restoration on ecosystem services (WP5). The legal, policy and governance outputs will make effective the potential of marine restoration (WP6) and one dedicated WP will assess the socio-economic returns of marine ecosystems restoration (WP7). The transfer of knowledge and the links with the industrial stakeholders will be the focus of WP8. The results of MERCES will be disseminated to the widest audience (WP9). The project will be managed through a dedicated management office (WP10). MERCES will contribute to the Blue Growth by: i) improving the EU scientific knowledge on marine restoration, ii) contributing to EU Marine Directives; iii) implementing the Restoration Agenda, iv) enhancing the industrial capacity in this field, v) increasing the competitiveness of EU in the world market of restoration, and vi) offering new employment opportunities.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: SST-2007-3.4-01 | Award Amount: 28.64M | Year: 2008

CIVITAS-ELAN is a large and ambitious project of great strategic importance to its project partners and funding institutions. The mayors of the cities of Ljubljana, Gent, Zagreb, Brno and Porto have agreed to a common mission statement To mobilise our citizens by developing with their support clean mobility solutions for vital cities, ensuring health and access for all. The five cities intend to cooperate on the basis of a clear set of common objectives, based on the principle of putting the citizen first. For each of the CIVITAS policy fields a common set of objectives and project goals has been agreed, and the cities have developed a programme of in total sixty-nine measures, which are described in detail, including concrete targets.The focus on citizen participation has been deeply built into the workplan, also several NGOs are part of the project consortium.The ELAN cities are representative of a growing number of dynamic, mainly medium-sized national or regional centres with strong cultural background. The planning of the project is mature with detailed timetable, resources and organisational structures. The project consortium is very experienced, some partners were involved in CIVITAS 1 and 2 from various perspectives. As requested in the call, a city from New Member States (NMS) (Ljubljana) is the project coordinator and a learning city (Brno) is also from a NMS. A further leading city (Zagreb) is from a candidate country thus bringing the CIVITAS initiative in the enlargement prospect. The workplan addresses topics of specific interest to cities in the NMS. Through CIVITAS-ELAN three new countries, Portugal, Croatia and Belgium will be put on the CIVITAS map as ELAN cities are committed to become ambassadors in their countries.As a policy-driven project, CIVITAS-ELAN will make significant contributions to major global, EU and national policy processes.

Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: KBBE.2010.1.3-04 | Award Amount: 1.16M | Year: 2011

The goal of AWARE is to promote integration and increase the impact of European research on farm animal welfare (FAW). It will do so through the development of Europe-wide networks of scientists, lecturers and students, and by establishing a network of stakeholders active in FAW knowledge transfer and implementation. AWARE actions will be organised in 3 mutually supportive Work Packages (WPs). WP A Research will enhance the integration of FAW research by fostering collaboration based on mutual recognition and by enhancing networking and proposal writing skills in motivated researchers throughout the enlarged Europe. WP B Education will promote cross-fertilisation in FAW university education, thus enhancing opportunities for young scientists in new and candidate countries to start research in FAW. WP C Awareness and Implementation focuses on enhancing public awareness, promoting implementation of EU policies, and facilitating uptake of FAW research. All 3 Work Packages proceed in 4 steps: 1. Mapping, 2. Establishing networks, 3. Improving skills and 4. Developing strategies for ongoing integration. Three horizontal activities support the WPs: a Mobility Desk facilitates mobility of researchers and students; the Communication module supports internal and external communication; and Management takes care of project management and effective communication with the Commission. AWARE will increase the European research capacity in FAW activities, through integrating the underutilized human and knowledge potential in the new and candidate countries. The project will result in faster and more comprehensive FAW knowledge transfer across Europe. It will also build for the future by drawing young scientists into FAW research and providing a base for harmonized implementation of FAW legislation in the enlarged EU.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EE-05-2016 | Award Amount: 3.00M | Year: 2016

Public bodies face the lack of appropriate easy-to-use tools to support them in the definition, simulation and evaluation of suitable strategies for sustainable heating and cooling tailored to local conditions for achieving the ambitious targets set-up in their local plans. In light of this, PLANHEAT main objective is to develop and demonstrate an integrated and easy-to-use tool which will support local authorities (cities and regions) in selecting, simulating and comparing alternative low carbon and economically sustainable scenarios for heating and cooling that will include the integration of alternative supply solutions (from a panel of advanced key technologies for the new heating and cooling supply) that could balance the forecasted demand. The PLANHEAT integrated tool will be designed to support local authorities in 1) mapping the potential of locally available low carbon energy sources (with specific reference to available RES and waste energy recoverable at urban and industrial level) 2) mapping the forecasted demand for heating and cooling 3) define and simulate alternative environmentally friendly scenarios based on district heating and cooling as well as highly efficient cogeneration systems matching the forecasted demand, levering on the use of RES and waste energy sources and with proven economic viability 4) understanding the interactions of these new scenarios with the existing infrastructures and networks (among which district heating and cooling gas, electricity, sewage, transportation) and identify potential for further extension and upgrade of district heating and cooling networks 5) evaluate the benefits (in terms of energetic, economic and environmental KPIs) that the adoption of the new scenarios will generate against the current situation (i.e., baseline). Moreover sound training and replication strategies involving a number of other public authorities have been set-up towards the empowerment of the expected project impacts.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.3.4 | Award Amount: 3.43M | Year: 2013

The wellbeing of the citizens in Europe depends on the reliable and efficient functioning of large interconnected systems, such as electric power systems, air traffic control, railway systems, large industrial production plants, etc. Such large systems consist of many interacting components, e.g. generation plants, distribution systems, and large and small consumers. The subsystems are usually managed locally and independently, according to different policies and priorities. The dynamic interaction of the locally managed components gives rise to complex behaviour and can lead to largescale disruptions as e.g. black outs in the electric grid.\n\n\nLarge interconnected systems with autonomously acting subunits are called systems of systems. DYMASOS addresses systems of systems where the elements of the overall system are coupled by flows of physical quantities, e.g. electric power, steam or hot water, materials in a chemical plant, gas, potable water, etc. Within the project, new methods for the distributed management of large physically connected systems with local management and global coordination will be developed.\n\n\nThe approaches explored are:\n\n\tModelling and control of large systems analogously to the evolution of the behaviour of populations in biological systems;\n\tMarketlike mechanisms to coordinate independent systems with local optimisation functions;\n\tCoalition games where agents that control the subsystems dynamically group to pursue common goals.\n\n\nThe properties of the distributed management and control techniques for large systems of systems are investigated theoretically and validated in largescale simulations of case studies provided by industrial partners in the fields of electric grid management and industrial production management.\n\n\nFrom the experience gained in the case studies, conclusions will be drawn about the suitability of the proposed management and control mechanisms for certain classes of systems of systems.\n\n\nThe expected technical outcomes of the project are:\n \tInnovation in distributed management methods for complex interconnected systems\n \tProgress in methods for the rigorous analysis and validation of systems of systems;\n \tImprovements in the management of electric grids and of large production complexes;\n \tTools for the engineering of management systems for systems of systems;\n \tIdentification of technology gaps in advanced management and coordination methods.\n\n\nThe developed coordination methods will lead to improved system stability and lower resource consumption in industrial production, and in electricpower generation and distribution. This will result in a reduction of the CO2-emissions, higher competitiveness of the European industry and lower prices for the customers. Thus, DYMASOS will contribute to the goal of a greener and more competitive Europe.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: KBBE-2007-2-4-05 | Award Amount: 6.75M | Year: 2009

Food Safety Objectives (FSO) and Performance Objectives (PO) are new criteria complementing the existing concepts of microbiological criteria and MRL for many chemical contaminants. However, to achieve these objectives it is critically important a harmonisation of food safety control procedures. BASELINE project intends to obtain the following objectives: 1) To review the sampling schemes currently available for food authorities and food producers to perform food safety quantitative risk assessment in a European level; 2) To assess the relevance and suitable limit values of POs and FSOs for biological and chemical risks; 3) To evaluate the need for new or adapted methods for sampling and testing of the risk factors identified. The selected protocols and methods should be able to produce suitable data for risk analysis; 4) To develop predictive mathematical models for biological risks and investigate and model sources and pathways of chemical contaminants to improve sampling schemes; 5) To validate and harmonise the sampling schemes developed in the project and alternative detection methods; 6) To share and disseminate the scientific knowledge deriving from the project to stakeholders. The BASELINE work plan has been divided in 9 work packages: WP1- management, WP2-WP6 sampling protocols for specific food matrixes, WP7-risk modelling, WP8-validation and harmonisation of sampling protocols, WP9-dissemination and training. The major output of the project is to generate new knowledge on sampling schemes for risk assessment by using a mathematical approach for different groups of food products as seafood, eggs and egg products, fresh meats, milk and dairy products and plant products. The project results will be translated in clear recommendations to the EC and end users and they will have a significant impact on protecting human and veterinary health.

Agency: Cordis | Branch: FP7 | Program: BSG-SME-AG | Phase: SME-2 | Award Amount: 3.31M | Year: 2008

The EU-27 industrial laundry sector, with 11.000 establishments (more than 90% SMEs), washes 2,7 billion kg of soiled textiles per year (wet weight) employing 168.000 workers and utilizing 42 million m3 of wash water and 60 PJ of energy per year. It generates similar quantities of waste water, to be treated, and substantial CO2 emissions (3,8 million tons CO2/year). The annual turnover of the sector is 5,1 billion euro, which can be doubled if all disposable textile articles were replaced by environmentally friendly reusable items. Focused and coordinated research to develop and improve innovative technologies can greatly enhance the performance of the sector. The conventional laundry processes are characterized by large enthalpy destructions and resource inefficiencies. It is the purpose of the project to design the SMART LAUNDRY-2015 through research, further development and adaptation of 16 key technologies (combined for green sites or individual for existing plant augmentation). These include water reduction, energy savings, green fuel substitutions for CO2 reductions, new energy systems and improved sequencing of the processes, greater textile hyiene. Full implementation of the SMART LAUNDRY-2015 will reduce the annual water consumptions by at least 10,4 million m3 (30%), the energy consumptions by 27,5 PJ (45%) and the overall CO2 emissions by 2,3 million tons CO2 per year (60% reduction) at 100% market penetration in the year 2015. Improved laundry services with the 16 key technologies and practices will enhance reusable textiles and reduce the throwaways and disposables by 20%. The 16 key technologies will be investigated at pilot scale level and subsequently integrated in a unified design. A parallel benchmarking and innovation monitoring will validate both the actual energy demand and the potential of energy savings of the future innovations. Future economic gains from SMILES are projected at 1020 million EUR in the next 10 years. An important component of project SMILES is the educational effort and training of key staff members and hand-on workers to assist in the introduction of the Smart Laundry-2015. The project also encompasses the writing, production and dissemination of key materials by a special website ( to national associations and to all SMEs in the sector. Finally the resource reductions are assured by an automated energy management system controlling and monitoring input and output savings. SMILES has 6 WPs: WP1 Water reduction, WP2 Energy/CO2 reduction, WP3 Chemicals reduction, WP4 Quality improvement/Risk analysis, WP5 Integration/Transfer and WP6 Project management. The project has a well-planned management structure for the cooperation between 5 SME-AGs, 2 SMEs and 8 RTDs from 7 EU countries.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.3.6 | Award Amount: 4.85M | Year: 2011

The main objective of the IMOLA project is the realization of a large-area OLED-based lighting module with built-in intelligent light management. Interesting applications are wall, ceiling and car dome lighting, where the light intensity can be adjusted uniformly or locally according to the time of the day or the position of a person, or even road lighting, where the light can follow a car.\n\nThe front side of the module consists of OLED tiles attached and interconnected to a flexible backplane foil. In an early stage of the project, individual tiles (on glass as well as on foil) will be used, but in a later stage OLED tiles on the roll will be laminated and interconnected to the backplane.\n\nThe backplane of the module contains the integrated driver electronics for the brightness control of the individual OLED tiles. A very thin and efficient smart-power chip converts a single 40V supply voltage into a controllable DC current for each OLED tile. This power converter chip employs an external passive component (inductor) that will preferably be embedded into the backplane foil. As the smart-power chip also allows the integration of dense CMOS circuitry, extra functionality and intelligence can be implemented on the chip. This includes optical feedback to eliminate non-uniformities between the tiles or to compensate OLED degradation effects. Other sensor functions can provide maximum interaction with the environment. Furthermore, advanced communication features, e.g. by means of PLC techniques across the power supply lines, can enable intelligent brightness control from a central unit.\n\nWithin the consortium, all necessary expertise is available to ensure perfect coverage of all technological aspects (such as OLED and backplane foil development, chip placement, electrical interconnect, component embedding and lamination) as well as all design aspects (driver chip design, inductor design and EMC) in this challenging project.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-30-2015 | Award Amount: 7.10M | Year: 2016

Connected smart objects have invaded our everyday life across multiple domains, e.g. home withautomation solutions, assisted living with sensors and wearables to monitor personal activities, smart transportation and environmental monitoring. IoT is evolving around a plethora of vertically isolated platforms, each specifically suited to given scenarios and often adopting non-standard, sometimes fully proprietary, protocols to control the variety of sensors, actuators and communication elements. symbIoTe comes to evolve this fragmented environment and provides an abstraction layer for a unified control view on various IoT platforms and sensing/actuating resources. symbIoTe designs and develops an IoT orchestration middleware capable of unified and secure access to physical and virtualized IoT resources; hierarchical and orchestrated discovery and control across multiple IoT platforms; federation of IoT controllers and resources for cooperative sensing/actuation tasks; seamless roaming of smart objects across smart spaces. symbIoTe builds its orchestration middleware on top of existing standards for protocols and interfaces, plus a number IoT platforms both proprietary (i.e. developed by its industrial partners) and from open source (e.g. OpenIoT). This unique set of backgrounds and foreground can result in a significant step forward in horizontal integration and federation of IoT domains. Five use cases with real large scale deployments have been selected to validate our vision in representative smart spaces: home/residence, educational campus, stadium, mobility and yachting. Engagement with real users is key in our validation process. With its research, symbIoTe can enable innovative business models for a large set of stakeholders of the IoT value chain, and particularly SMEs and new entrants in the IoT market. The consortium includes direct beneficiaries of these impacts, including small and large industry with IoT business and renowned research performers.

Agency: Cordis | Branch: H2020 | Program: Shift2Rail-RIA | Phase: S2R-OC-CCA-04-2015 | Award Amount: 1.30M | Year: 2016

The GoSAFE RAIL project will be transformative for asset safety in the rail sector. It will bring together inter-disciplinary experts from Risk based asset assessment of infrastructure, Artificial Intelligence (AI), object detection and data management sectors with leaders in network micro-simulation modelling to deliver a Decision Support Tool that will allow a step change for infrastructure safety. The involvement of Infrastructure Managers and Railway Undertakings will ensure the R&D performers have access to data and through collaboration with the Shift2Rail initiative and complementary H2020 projects, access to demonstration sites (a number of preferred tunnel and bridge monitoring locations have already been selected) necessary to develop the tool and a ready market to commercialise it. Through the development of a Network Decision Support Tool the project will provide integrated solutions to issues related to infrastructure safety and planning considering a number of common problems faced by EU infrastructure managers. The project aligns directly with the Shift2Rail (S2R) masterplan and the three technology demonstrator projects in the Intelligent Asset Maintenance pillar (TD 3.6, 3.7 and 3.8). In particular it will address (i) Integration of Open-Linked Data from a range of sources and transformation to allow for direct use in a safety framework incorporating network modeling, (ii) Real-time methods for object detection will be developed and demonstrated, (iii) Analytical models incorporating Artificial Intelligence (AI) algorithms will be developed to predict asset degradation and (iv) The safety framework can be used to plan maintenance and intervention strategies with the lowest whole life cycle cost.

Flemr M.,Academy of Sciences of the Czech Republic | Malik R.,Academy of Sciences of the Czech Republic | Franke V.,University of Zagreb | Nejepinska J.,Academy of Sciences of the Czech Republic | And 4 more authors.
Cell | Year: 2013

Summary In mammals, a single Dicer participates in biogenesis of small RNAs in microRNA (miRNA) and RNAi pathways. In mice, endogenous RNAi is highly active in oocytes, but not in somatic cells, which we ascribe here to an oocyte-specific Dicer isoform (DicerO). DicerO lacks the N-terminal DExD helicase domain and has higher cleavage activity than the full-length Dicer in somatic cells (DicerS). Unlike Dicer S, DicerO efficiently produces small RNAs from long double-stranded (dsRNA) substrates. Expression of the DicerO isoform is driven by an intronic MT-C retrotransposon promoter, deletion of which causes loss of DicerO and female sterility. Oocytes from females lacking the MT-C element show meiotic spindle defects and increased levels of endogenous small interfering RNA (endo-siRNA) targets, phenocopying the maternal Dicer null phenotype. The alternative Dicer isoform, whose phylogenetic origin demonstrates evolutionary plasticity of RNA-silencing pathways, is the main determinant of endogenous RNAi activity in the mouse female germline. © 2013 Elsevier Inc.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP-2010-3.4-1 | Award Amount: 9.01M | Year: 2011

The MAPICC 3D project and concept aims at developing manufacturing system for 3D shaped, multilayered products based on flexible materials. The ultimate goals are: > The development of integrated and automated process chain able to produce from hybrid thermoplastic yarn to 3D complex shaped thermoplastic composite structure in single step thermoplastic consolidation process. > The development of flexible industrial tools, able to produce customized final composites: possibility to reinforce the preform by coating, weaving multilayers, by injection of foam, by introduction of sensors (control quality of preform during the production or monitor the integrity of composite during use) > The development of modelling tool in order to help understanding of the mechanisms involved in the new technologies and to prototype virtually 3D preform, predictive tools to evaluate the physical and mechanical properties of final 3D preform and final composites structure and at the last step reverse engineering. The speed of production and the cost of manufacturing the 3D preform will be in accordance with the transport, building and energy thanks to: The use of raw materials at low cost based on thermoplastic polymer, or regenerated fibres, A decrease of production time. The polluting, labour-intensive and expensive steps of cutting, forming and joining, of current composites production could be avoiding. A dynamic quality control during the production to improve the process robustness, A decrease of quantity of wastes in comparison to current 2D preform based composite structures manufacturing. The consortium allows integrating the entire process chain and involves the industrial stakeholders from machine tools, automation and modelling processing of flexible materials, yarn and textiles, composites and end users for transport: industry insures the leadership of the project.

Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.26. | Award Amount: 8.20M | Year: 2013

This project aims at integrating the major European infrastructures in the field of high-resolution solar physics. The following actions will be taken: (i) realise Trans-national Access to external European users; (ii) enhance and spread data acquisition and processing expertise to the Europe-wide community; (iii) increase the impact of high-resolution data by offering science-ready data and facilitating their retrieval and usage; (iv) encourage combination of space and ground-based data by providing unified access to pertinent data repositories; (v) foster synergies between different research communities by organising meetings where each presents state-of-the-art methodologies; (vi) train a new generation of solar researchers through setting up schools and an ambitious mobility programme; (vii) develop prototypes for new-generation post-focus instruments; (vii) study local and non-local atmospheric turbulence, their impact on image quality, and ways to negate their effects; (viii) improve the performance of existing telescopes; (ix) improve designs of future large European ground-and space-based solar telescopes; (x) lay foundations for combined use of facilities around the world and in space; (xi) reinforce partnership with industry to promote technology transfer through existing networks; and (xii) dissemination activities towards society. The project involves all pertinent European research institutions, infrastructures, and data repositories. Together, these represent first-class facilities. The additional participation by private companies and non-European research institutions maximizes the impact on the world-wide scale. In particular, the project achievements will be of principal importance in defining the exploitation of the future 4-meter European Solar Telescope.

Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: ENERGY.2010.5.2-2 | Award Amount: 2.62M | Year: 2010

The EU has made significant progress in CCS as a bridging technology for combating climate change, but this must now accelerate and be spread evenly throughout EU Member States and Associated Countries. In this context, CO2GeoNet, CO2NET EAST and ENeRG are joining forces, pooling their expertise and building on their Networking experience to form CGS Europe, a unique concerted European reference point on CO2 storage. The objective of CGS Europe is to build a credible, independent and representative pan-European scientific body of expertise on CO2 geological storage that will: (i) create a durable networking of research capacity on CO2 storage in Europe, (ii) liaise and coordinate its activities with other stakeholders, including the ZEP Technology Platform, (iii) facilitate the large-scale demonstration and industrial deployment of CCS, (iv) support the implementation of the EU Directive on the geological storage of CO2 and other regulatory regimes. This will be achieved by: (i) setting up coordination and integration mechanisms between the CO2GeoNet Association and the 23 other participants, thus covering most of Europe with 24 EU Member States and 4 Associated Countries, (ii) setting up links and cooperation with other initiatives at national, European and international levels, (iii) preparing a framework enabling the consortium to be independent from EC funding after the end of the project. CGS Europe will strive to compile and structure the existing research results, policy and regulations in a centralised knowledge repository to enable stakeholders to easily find pertinent information. Knowledge development will be ensured by the sharing of good practices, the assessment of research needs and the fostering of new research projects. A major effort will be dedicated to knowledge dissemination and capacity building, aiming at giving impartial and understandable information to the different stakeholders, according to their specific needs in each country.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: ENV.2008. | Award Amount: 9.17M | Year: 2009

Groundwater resources are facing increasing pressure from consumptive uses (irrigation, water supply, industry) and contamination by diffuse loading (e.g. agriculture) and point sources (e.g. industry). This cause major threat and risks to our most valuable water resource and on ecosystems dependent on groundwater. New information is need on how to better protect groundwaters and groundwater dependent ecosystems (GDE) from intensive land-use and climate change. The impacts of land-use changes and climate changes are difficult to separate as they partly result in similar changes in the ecosystems affected. The effects are highly interwoven and complex. The EU groundwater directive (GWD) and the water framework directive (WFD) provide means to protect groundwater (GW) aquifers from pollution and deterioration. At present, the maximum limits for groundwater pollutant concentrations have been set for nitrate and various pesticides. Also, water of sufficient quality and quantity should be provided to ecosystems dependent on groundwater. The European aquifers differ by their geology, climate, and threats to aquifers. This must be considered when general guidelines for management of these systems are developed. The concept of the present proposal is to base the research on different relevant aquifer sites in various European countries to test scientific issues and find new results to important problems. Seven WP are foreseen: WP1 Case studies on impacts and threats to GWs and GDEs WP2 Groundwater dynamics, re-charge and water balance WP3 Leaching to groundwater aquifers from different land-uses WP4 Groundwater dependent ecosystems: groundwater-surface water interaction WP5 Modelling processes in groundwater systems WP6 Concepts, scenarios and risk assessment WP7 Co-ordination

Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2011-1.1.20. | Award Amount: 12.58M | Year: 2012

The Project promotes the access to five European Research Infrastructures, and it is structured into nine Networking Activities, plus the Management of the Consortium, and fourteen Joint Research Activities. The Project will profit of the success of the previous HadronPhysics project in FP6 and the current HadronPhysics2 in FP7, and originates from the initiative of more than 2.500 European scientists working in the field of hadron physics. Hadron physics deals with the study of strongly interacting particles, the hadrons. Hadrons are composed of quarks and gluons. Their interaction is described by Quantum Chromo Dynamics, the theory of the strong force. Hadrons form more complex systems, in particular atomic. Under extreme conditions of pressure and temperature, hadrons may loose their identity and dissolve into a new state of matter similar to the primordial matter of the early Universe. The Networking Activities are related to the organization of experimental and theoretical collaborative work concerning both ongoing activities at present Research Infrastructures and planned experiments at future facilities. In hadron physics the close interaction between experimentalists and theoreticians is of paramount importance. The Joint Research Activities concentrate on technological innovations for present and future experiments. Applications in material science, medicine, information, technology, etc., represent natural fall-outs. The main objective of this Integrating Activity is to optimize the use and development of the Research Infrastructures existing in Europe working in the field of hadron physics. The Project aims as well at structuring, on European scale, the way Research Infrastructures operate, and at fostering their joint development in terms of capacity and performance. The approach used is the bottom up approach, to respond to the needs of the scientific community in all fields of science and technology.

Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: ENERGY-2007-3.7-01;ENERGY-2007-7.3-01 | Award Amount: 1.34M | Year: 2008

The main objective of the project is to develop a common methodology for gathering information on biomass potential using terrestrial and earth observations. This objective will be achieved by the implementation of a systematic assessment work plan and will result in the establishment of a harmonised approach and an e-training tool for dissemination. The e-training environment will be an important tool for reaching the much-needed European harmonisation, whereas a Stakeholder Platform will facilitate access to reliable and common datasets on biomass potential and as such it will offer a more efficient use of the available European biomass feedstock. The project will: - Develop a common methodology for gathering information on biomass potential using terrestrial and earth observations - Use e-technologies for disseminating information, best practices on the use and applicability of developed harmonised methodology

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2013.6.3-1 | Award Amount: 4.50M | Year: 2014

An estimated one billion tyres are discarded each year. Post-Consumer tyre arisings for EU countries (2010) are 3.4M tonnes per year. At the moment nearly 50% of all recycled tyres/components still end up as fuel, in low grade applications or in landfill. All tyre constituents (rubber, high strength steel cord and wire, high strength textile reinforcement) are high quality materials and deserve to be reused for their relevant properties. Construction is the highest user of materials with concrete being the most popular structural material. Concrete is inherently brittle in compression (unless suitably confined) and weak in tension and, hence, it is normally reinforced with steel bars or fibres. The authors believe that highly confined rubberised concrete can lead to highly deformable concrete elements and structures and that tyre steel and textile fibres can be used as concrete reinforcement to control shrinkage cracking. Hence, the aim of this proposal is to develop innovative solutions to reuse all tyre components in high value innovative concrete applications with reduced environmental impact. To achieve this aim, the proposed project will have to overcome scientific and technological challenges in: Development of novel confined rubberised concrete materials and reinforcement Development of high deformability RC elements suitable for integral bridge elements and base isolation systems for vibrations and seismic applications Development of concrete mixes using recycled steel fibres for use in various applications such as slabs on grade, suspended slabs, precast concrete elements and pumpable self compacting concrete or screed Development of concrete mixes using recycled tyre polymer fibres for crack control Development of novel concrete applications using combinations of the different tyre by-products Undertaking demonstrations projects using the developed materials/applications Development and implementation of standardised LCA/LCCA protocols

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY-2007-5+6.2-04 | Award Amount: 5.43M | Year: 2008

The main objective of ECCO is to facilitate robust strategic decision making regarding early and future implementation of CO2 value chains for Europe in the face of uncertainty. The project will provide recommendations enabling cost-effective use of the CO2 being produced from zero-emission power plants and other industries in Europe by exploring the assets and challenges of CO2 for enhanced hydrocarbon production (EOR/EGR) in a value-chain context. ECCO responds to the need for a European joint effort towards overcoming the barriers to the deployment of CCS. The core group of the project is constituted by 18 legal entities, all of them committed to the execution of ECCO. These encompass 7 energy providers (oil & gas companies and utilities), 2 engineering companies, 1 NGO and 8 highly ranked RTD providers representing bordering countries around the North Sea basin and in Central and Eastern Europe. ECCO -short for European Value Chain for CO2- is designed as a Collaborative Project (small to medium scale focused project). The R&D activities are structured in four sub-projects (SP) directly responding to the objectives of the Work Programme: SP1 ECCO dissemination and training SP2 CCS analysis and recommendations SP3 CO2 value chain methodology and tool development SP4 Reservoir technology for EOR/EGR The knowledge, methods, and tools developed in ECCO shall influence future CCS initiatives by enabling the industrial players and the authorities to analyse, understand, and make sound decisions within the topic of CO2 value chains. Key expected impacts of ECCO, all complying with the Work Programme are: Underpin the realisation of CO2 value chains for captured CO2 from large point sources for CO2 injection in petroleum reservoirs (EOR/EGR) and CO2 storage. Improve security of supply by enabling sustainable use of fossil fuels, protracting increases in fuel imports by making better use of existing resources and shortening time t

Agency: Cordis | Branch: FP7 | Program: NOE | Phase: ICT-2007.1.1 | Award Amount: 4.75M | Year: 2008

The BONE-proposal builds on the foundations laid out by the ePhoton/ONe projects in the previous Framework Programme. This Network of Excellence has brought together over several years the research activities within Europe in the field of Optical Networks and the BONE-project intends to validate this effort by stimulating a more intensified collaboration, exchange of researchers and building on Virtual Centres of Excellence that can serve to European industry with education and training, research tools and testlabs and pave the way to new technologies and architectures.\nThe Network of the Future, which is the central theme of this Call, will have to cope with a wide variety of applications running on a wide variety of terminals and with an increasing number of connected devices and increasing speed and data-loads. The BONE-proposal does not look into issues as convergence between mobile and fixed networks, nor does it consider issues regarding the optimised broadband access in the last mile using a wide variety of technologies such as DSL, cable, WiMAX, WiFi, PLC,... The BONE-proposal looks further into the future and takes as the final Network of the Future:\n- a high capacity, flexible, reconfigurable and self-healing optical Core and Metro network which supports the transport of massive amounts of data\n- a FTTx solution in which the x is as close as possible to the home, at the home, or even in the home. From this point the user is connected using terminal-specific technologies (wireless to handheld devices, fiber to home cinema, wireless to laptop, fixed connection to desktop,...)\nBONE clearly identifies the existence of the current technologies and also recognizes the fact that users also require the mobility of wireless access, but this mobile connection ends at a gateway or access points and from there a fixed connection is required and this fixed connection will finally be an optical link.

Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: ENERGY-2007-3.7-01 | Award Amount: 2.82M | Year: 2008

The objective of the project is to harmonise biomass resource assessments, focusing on the availability of biomass for energy in Europe and its neighbouring regions. This harmonisation will improve the consistency, accuracy and reliability of biomass assessments, which can serve the planning of a transition to renewable energy in the European Union. The project activities will include (i) the analysis of recently conducted biomass resource assessments, (ii) the analysis of policy backgrounds, sustainability criteria and user requirements, (iii) the analysis of currently applied methodologies, (iv) an inventory of data sources and ongoing activities aimed at improved data quality and accessibility, (v) a proposal for a harmonised biomass potential assessment methodology, (vi) an illustration and validation of the developed approach in case studies at EU-27, the Pan-European level and for select countries, (vii) an evaluation of the harmonised approach and if necessary the identification of priorities for further development. The major focus will be (1) on methodological and dataset harmonisations fostered by ongoing research of a multidisciplinary team of project participants and (2) on the opportunities of utilising both earth observation and terrestrial data for biomass assessments and the integration of multiple data sources. The relevant sectors that will be investigated are forestry, energy crops and residues from traditional agriculture and waste. The consortium will build on its complementary sectorial expertise, which will allow the production of sector-overarching studies, taking competitive and economic aspects into account. Intensive scientific cooperation and dissemination will comprise the discussion of its objectives, interim and final results with stakeholders including the EC DGs, EEA, Eurostat, UN/ECE, research, industry, national ministries and associated authorities and sectorial organisations (ren. energy, agriculture, forestry, waste)

Agency: Cordis | Branch: FP7 | Program: CP-SICA | Phase: ENV.2007. | Award Amount: 3.84M | Year: 2008

Biodiversity conservation increasingly takes place outside protected areas in multiple-use landscapes. Success in achieving biodiversity objectives is closely linked to the extent to which conservation can be integrated with the cultural, social and economic objectives and aspirations of people. Beliefs, perceptions, attitudes and preferences about biodiversity are central to the decisions made by individuals and groups about natural resource management. In this project we will use hunting as a lens through which to examine the wider issue of how people interact with biodiversity. Hunting provides a valuable case study in the use of biodiversity because it involves tens of millions of people globally, it is conducted across a wide range of land tenure and use systems, and it is an important source of revenue and protein, particularly in developing countries. Hunting is embedded in social structures and cultural patterns and has a key role in conflicts over natural resource management around the world. Our multidisciplinary team will assess the social, cultural, economic and ecological functions and impacts of hunting across a range of contexts in Europe and Africa. Our study systems fall across economic gradients from the richest to the poorest countries and encompass environments from the Arctic to the Equator. We seek to understand what influences attitudes to hunting, how these attitudes influence and determine individual and societal behaviour in relation to hunting, and finally, how hunting behaviour influences biodiversity. Consequently, we will integrate social, economic and ecological scientific disciplines and engage with a diverse selection of stakeholders to develop novel approaches to the mitigation of natural resource conflicts involving hunting. Finally, our results will be interpreted in respect to current and future EU policy on hunting and biodiversity conservation and contribute to the global debate about the sustainable use of biodiversity.

Agency: Cordis | Branch: H2020 | Program: CSA | Phase: LCE-14-2014 | Award Amount: 709.47K | Year: 2015

The overall objective of Bin2Grid concept is to promote segregated collection of food waste as energy source, conversion to biogas, and its upgrading to biomethane and utilization in associated network of filling stations. To that end, accent will be given to defining strategies for establishing efficient network of food and beverage waste collection methods and practices. Also, whole range of food waste producers will be taken under consideration, i.e. manufacturing entities, catering/food services, retail stores. Since biological treatment (anaerobic digestion) is without an alternative for energy utilization of food waste and together with other raw materials creates a synergy for renewable energy production (biogas/biomethane). One of the biggest advantages of such a concept of energy production is having two issues covered at the same time: environmental protection with sustainable management of food waste and the production of renewable energy with its utilization as a biofuel. The existing technologies which are specific for this kind of raw materials will be explored. Having in mind that chemical energy of biogas is fully used when it has been upgraded to biomethane and used as a biofuel, particular attention will be given to advanced biogas to biomethane upgrading techniques for purification and technical requirements for its usage through local filling stations as a biofuel, in public transportation sector in particular (e.g. waste management trucks).

Jentink J.,University of Groningen | Loane M.A.,University of Ulster | Dolk H.,University of Ulster | Barisic I.,University of Zagreb | And 3 more authors.
New England Journal of Medicine | Year: 2010

BACKGROUND: The use of valproic acid in the first trimester of pregnancy is associated with an increased risk of spina bifida, but data on the risks of other congenital malformations are limited. METHODS: We first combined data from eight published cohort studies (1565 pregnancies in which the women were exposed to valproic acid, among which 118 major malformations were observed) and identified 14 malformations that were significantly more common among the offspring of women who had received valproic acid during the first trimester. We then assessed the associations between use of valproic acid during the first trimester and these 14 malformations by performing a case-control study with the use of the European Surveillance of Congenital Anomalies (EUROCAT) antiepileptic-study database, which is derived from population-based congenitalanomaly registries. Registrations (i.e., pregnancy outcomes with malformations included in EUROCAT) with any of these 14 malformations were compared with two control groups, one consisting of infants with malformations not previously linked to valproic acid use (control group 1), and one consisting of infants with chromosomal abnormalities (control group 2). The data set included 98,075 live births, stillbirths, or terminations with malformations among 3.8 million births in 14 European countries from 1995 through 2005. RESULTS: Exposure to valproic acid monotherapy was recorded for a total of 180 registrations, with 122 registrations in the case group, 45 in control group 1, and 13 in control group 2. As compared with no use of an antiepileptic drug during the first trimester (control group 1), use of valproic acid monotherapy was associated with significantly increased risks for 6 of the 14 malformations under consideration; the adjusted odds ratios were as follows: spina bifida, 12.7 (95% confidence interval [CI], 7.7 to 20.7); atrial septal defect, 2.5 (95% CI, 1.4 to 4.4); cleft palate, 5.2 (95% CI, 2.8 to 9.9); hypospadias, 4.8 (95% CI, 2.9 to 8.1); polydactyly, 2.2 (95% CI, 1.0 to 4.5); and craniosynostosis, 6.8 (95% CI, 1.8 to 18.8). Results for exposure to valproic acid were similar to results for exposure to other antiepileptic drugs. CONCLUSIONS: The use of valproic acid monotherapy in the first trimester was associated with significantly increased risks of several congenital malformations, as compared with no use of antiepileptic drugs or with use of other antiepileptic drugs. Copyright © 2010 Massachusetts Medical Society. All rights reserved.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EINFRA-1-2014 | Award Amount: 8.65M | Year: 2015

Over the last decade, the European Grid Infrastructure (EGI) has built a distributed computing and data infrastructure to support over 21,000 researchers from many disciplines with unprecedented data analysis capabilities. EGI builds on the European and national investments and relies on the expertise of - a not-for-profit foundation that provides coordination to the EGI Community, including user groups, participants in the EGI Council, and the other collaborating partners. The mission of EGI-Engage is to accelerate the implementation of the Open Science Commons vision, where researchers from all disciplines have easy and open access to the innovative digital services, data, knowledge and expertise they need for their work. The Open Science Commons is grounded on three pillars: the e-Infrastructure Commons, an ecosystem of key services; the Open Data Commons, where any researcher can access, use and reuse data; and the Knowledge Commons, in which communities have shared ownership of knowledge and participate in the co-development of software and are technically supported to exploit state-of-the-art digital services. EGI-Engage will expand the capabilities offered to scientists (e.g. improved cloud or data services) and the spectrum of its user base by engaging with large Research Infrastructures (RIs), the long-tail of science and industry/SMEs. The main engagement instrument will be a network of eight Competence Centres, where National Grid Initiatives (NGIs), user communities, technology and service providers will join forces to collect requirements, integrate community-specific applications into state-of-the-art services, foster interoperability across e-Infrastructures, and evolve services through a user-centric development model. The project will also coordinate the NGI efforts to support the long-tail of science by developing ad hoc access policies and by providing services and resources that will lower barriers and learning curves.

CRISS is a user-driven, flexible, scalable and cost-effective cloud-based digital learning ecosystem that allows the guided acquisition, evaluation and certification of digital competences in primary and secondary education, and easily scalable to other educational levels. CRISS proposes an innovative adaptive learning solution supported by the most advanced pedagogical methodologies and technologies that will be tested with a very large scale pilot with more than 490 schools including 25.400 students and 2.290 teachers across Europe. CRISS aim to contribute to the modernisation of the educational and training system at different levels: a) Support schools and educational institutions in the definition and creation of a curricular programming aligned to European and national policies, encouraging the active participation of all teachers and creating an interdisciplinary framework and highly diversified contents, activities and educational experiences for the acquisition and evaluation digital competences of students. b) Offers teachers and students an adaptive and intelligent environment for personalizing the process of teaching and learning that allows them to easily and dynamically generate and integrate programming a wide variety of new learning experiences and integrate new methodologies, fostering a creative and motivating use of technologies focused on minimizing the distance between digital competences acquired at school and the required in the labour market. c) Through its learning analytics module CRISS can generate an innovative and unique student ICT Dynamic Profile, showing strengths and weaknesses, achievements, interests, skills acquired, certification and other recognition, on the one hand facilitating the personalization of teaching / learning, and on the other the entry into the labour world. d) Thanks to its evaluation and certification of digital competences will contribute to the standardization of digital competences at European level.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: KBBE.2010.2.4-01 | Award Amount: 3.49M | Year: 2012

The general objectives of PROMISE are: PROMISE strives for multidimensional networking thus fostering integration The primary strategic objective of PROMISE is to improve and increase the integration, collaboration and knowledge transfer between the new member states, old member states (EU15) and candidate countries through a collaborative workplan of exchange of expertise and regional training and dissemination actions, to tackle common food safety threats. PROMISE strives for sustainability through involvement of risk communicators A further strategic objective is to integrate stakeholders like public health authorities and national food safety authorities from the old and new member countries in order to ensure the exploitation of research results into standardisation and harmonisation efforts. PROMISE will enhance the knowledge on pathogen transmission While legal imports are well monitored for contamination and alerts are registered through the Rapid Alert System for Food and Feed (RASFF; notification systems, gates into the EU-27 could exist where food supply chains are not controllled. These uncontrolled imports present the risk that new strains of traditional pathogens will be transferred from third countries into the European Union. Analysing, assessing and interpreting this risk of introducing new strains of pathogens is one of the main objectives of PROMISE.

In Europe, there is a clear long-term objective to decarbonize the energy system, but it is very unclear how this will be achieved in the heating and cooling sector. As a result, there is currently a lot of uncertainty among policymakers and investors in the heating and cooling sector, primarily due to a lack of knowledge about the long-term changes that will occur in the coming decades. This HRE proposal will enable new policies as well as prepare the ground for new investments by creating more certainty in relation to the changes that are required. The work in this proposal will build on three previous HRE studies, all of which have been successfully completed on time and all of which have already influenced high-level policymakers at EU and national level in Europe. The work from these previous studies will be significantly improved in this project. The new knowledge in this project will: - Improve at least 15 new policies at local, national, or EU level, - Specify how up to 3,000,000 GWh/year of fossil fuels can be saved in Europe, and - Quantify how the 3 trillion of investment required to implement these savings will reduce the net cost of heating and cooling in Europe. Furthermore, one of the most significant improvements compared to previous studies is the dissemination and communication strategy that has been developed as part of this proposal. These activities represent the largest work package in this proposal, which is necessary to ensure that policymakers, investors, and researchers at local, national, and EU level are all aware of the new data, tools, methodologies, and results from this project. The dissemination activities are expected to directly build the skills and capacity of at least 350 people in specific target groups identified by the consortium, while the communication activities will inform at least 50,000 people about the project activities and results.

Agency: Cordis | Branch: H2020 | Program: CSA | Phase: INFRADEV-02-2016 | Award Amount: 9.05M | Year: 2017

The European Solar Telescope (EST) will be a revolutionary Research Infrastructure that will play a major role in answering key questions in modern Solar Physics. This 4-meter class solar telescope, to be located in the Canary Islands, will provide solar physicists with the most advanced state-of-the-art observing tools to transform our understanding of the complex phenomena that drive the solar magnetic activity. The principal objective of the present Preparatory Phase is to provide both the EST international consortium and the funding agencies with a detailed plan regarding the implementation of EST. The specific objectives of the proposed preparatory phase are: (1) to explore possible legal frameworks and related governance schemes that can be used by agencies to jointly establish, construct and operate EST as a new research infrastructure, with the implementation of an intermediate temporary organisational structure, as a previous step for future phases of the project; (2) to explore funding schemes and funding sources for EST, including a proposal of financial models to make possible the combination of direct financial and in-kind contributions towards the construction and operation of EST; (3) to compare the two possible sites for EST in the Canary Islands Astronomical Observatories and prepare final site agreements; (4) to engage funding agencies and policy makers for a long-term commitment which guarantees the construction and operation phases of the Telescope; (5) to involve industry in the design of EST key elements to the required level of definition and validation for their final production; (6) to enhance and intensify outreach activities and strategic links with national agencies and the user communities of EST. To accomplish the aforementioned goals, this 4-year project, promoted by the European Association for Solar Telescopes (EAST) and the PRE-EST consortium, encompassing 23 research institutions from 16 countries, will set up the Project Office

Agency: Cordis | Branch: FP7 | Program: BSG-SME | Phase: SME-1 | Award Amount: 1.48M | Year: 2009

The EECS project brings together three European SMEs and three academic researchers in order to develop a prototype campus card management system that will serve the unique needs and requirements of European Higher Education Institutions. EECS will recommend standards for campus card systems to the ISO and will build the prototype to the recommended standards in order to facilitate interoperability between campus card management systems across Europe. The EECS project will give the participating SMEs access to trans-European research and development, which will deliver an interoperable card management system. The consortium will work with the European Campus Card Association (ECCA) to develop the most appropriate solution for European campuses, based on the unique needs of Higher Education institutions. The EECS project will produce an integrated campus card solution, which will be exploited by the partner SMEs. This is a highly ambitious goal achievable through state of the art research and the careful partnering of Research and Technological Development (RTD) performers and SME partners. Typically, access to such research capability is confined to the multinational organizations. The EECS goals are, therefore, ideally suited to the Research for SMEs program. The core technological ambitions of the project are to: - Facilitate the interoperability of campus systems and basic functionalities, including the transfer of student information and access to a range of fundamental campus services for students. - Develop an information transmission interface that will translate information stored on one campus card into a common format based on European standards. - Facilitate the secure authentication of information transfer between educational institutions. The project aims to fulfill the main objectives of the Bologna Declaration by promoting mobility by overcoming obstacles to the effective exercise of free movement of students and academics.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: ENV.2008. | Award Amount: 6.56M | Year: 2009

Climate change is one of the most critical global challenges of our time which also threatens cultural heritage. As a non-renewable important resource to the European identity, sustainable adaptation strategies are required for long term preservation. For this purpose and for the first time ever, the CLIMATE FOR CULTURE project will couple completely new high resolution (10x10km) climate change evolution scenarios with whole building simulation models to identify the risks for specific regions. The innovation lies in the elaboration of a more reliable damage assessment by connecting the future climate data with whole building simulation models and new damage assessment functions. In situ measurements at UNESCO sites throughout Europe will allow a much more precise and integrated assessment of the real damage impact of climate change on cultural heritage. Appropriate sustainable mitigation/adaptation strategies, also from previous projects, are further developed and applied on the basis of these findings simultaneously. All these results will be incorporated into an assessment of the economic impacts. In order to ensure an efficient use of resources, this project will build on the results of already concluded EU research projects (Noahs Ark). Techniques from FP5/6 projects will be reassessed for their applicability in future scenarios at different regions in Europe and Mediterranean to fully meet sustainability criteria. The proposed project will thus be able to estimate more systematically the damage potential of climate change on European cultural heritage. The team consists of 27 multidisciplinary partners from all over Europe and Egypt including the worlds leading institutes in climate modelling and whole building simulation. The final achievement of the project will be a macro-economic impact report on cultural heritage in the times of climate change akin to the STERN report which would be a truly European contribution to future IPCC Reports.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-3.1-5 | Award Amount: 3.63M | Year: 2009

The APRES project aims at providing information and recommendations on the appropriateness of prescribing antibiotics in primary care. The appropriateness of prescribing antibiotics is the extent to which the pattern of prescribed antibiotics is congruent with the antibiotic resistance pattern of bacteria. More than 90% of antibiotics in Europe is prescribed to non-hospitalized patients, but existing information on the antibiotic resistance pattern is exclusively based on samples from hospitalized patients. Guidelines for prescribing antibiotics to outpatients cannot be based on empirical evidence about antibiotic resistance of bacteria circulating in the community because this evidence is lacking. The APRES project contains 4 work packages. WP1 includes a) a systematic review on the relationship between outpatient consumption of antibiotics and patterns of antibiotic resistance of pathogens circulating in the community; b) the establishment of a database of information sources and databases in nine European countries on outpatient consumption of antibiotics and antibiotic resistance patterns of pathogens circulating in the community. In WP2 the antibiotic resistance pattern of S. aureus and S. pneumoniae will be established in nine European countries, based on samples from healthy persons consulting in primary care practices participating in nationally representative networks. In WP3 we will establish the 5-year pattern of prescribed antibiotics the same practices and its variation between nine European countries. The data will be retrieved from electronic medical records in the same primary care practices. WP4 includes the integrative analyses by linking the antibiotic prescribing data with the antibiotic resistance patterns obtained in the same practices to establish the appropriateness of prescribing antibiotics. On the basis of these results, country specific guidelines will be formulated for appropriate prescribing of antibiotics.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SFS-07a-2014 | Award Amount: 3.40M | Year: 2015

Research and development activities are proposed for the benefit of sustainable pork chains based on European local pig breeds and their production systems. Workprogramme is planned to respond to consumer demands for quality and healthiness of pork products with regional identity and societal demands for environment preservation and development of local agro-economy. Description and evaluation of local pig breeds, with an emphasis on untapped ones will be performed using novel genomic tools. Performance of local pig breeds will be evaluated in contrasted agro-geo-climatic conditions and production systems (indoor, outdoor, organic). Focus will be on pig feeding and management strategies and on the use of locally available feeding resources. Intrinsic quality of traditional and new regional high quality pork products and attitudes of consumers from various market areas will be assessed; in particular the motives for the choice and willingness to pay such products. Marketing strategies will be adressed in particular short chain distribution channels. All activities will be driven from the perspective of sustainability (environmental impact, animal welfare, product quality, consumer acceptability and market potential). The activities will engage innovative approaches to answer socio-economic demands of regional pork chains involving partners from different sectors. The ambition is to enhance existing and create new networks between academia and non-academia partners, within and between regions and to tackle the value chain for regional high quality pork products, focusing on diverse and so far untapped pig breeds, their production systems and pork products. Cross-fertilising interactions between research, local agriculture, businesses and end-users will be achieved with partners from these complementary sectors in all research and development activities.

Agency: Cordis | Branch: FP7 | Program: CP-SICA | Phase: KBBE-2007-2-1-02 | Award Amount: 3.04M | Year: 2008

The general objective of the FOCUS-BALKANS project is to improve competencies and understanding in the field of consumer food science in the Western Balkan countries (WBC). The scientific results of the research will make important contribution to the public health and consumer protection and to the achievement of the objectives within the FP7. The specific objectives are to: - Develop a network of universities, institutes, high schools, consumer organisations, NGOs and private enterprises active in the field of food consumer science with are able to develop joint-research activities; - Have a better understanding of food consumers in the WBCs, with a focus on products with positive nutritional properties (fruits and health / diet foods) and / or sustainability (organic and traditional food products). Formal training will be organised for key research organisations in the WBCs to enable them to become familiar with state of the art methodologies, practical techniques and theories. The training activities, organised in each WBC-country, target a wide range of organisations from the public and private research sectors, NGOs & consumer associations. 6 regional training meetings will be designed by the project partners and associated organisations. Four studies on niche markets plus one quantitative survey will systematically be conducted by WBC organisations as a mechanism for learning-by-doing. Two open seminars will bring together a wider spectrum of stakeholders including food supply chains representatives and policy-makers. Altogether, these actors will be invited to participate in the Food Consumer Science Balkan Network, which will seek to stimulate regional and interdisciplinary co-operation. The research, training and networking activities are intimately interlinked and will have strong synergies.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2009-3.1-2;HEALTH-2009-3.2-1 | Award Amount: 2.48M | Year: 2009

To date, relatively little evidence has been published as to what represents an effective and efficient way to improve quality of care and safety in hospitals. This vacuum in the research means there is a significant opportunity to design quality of care and safety interventions in collaboration with the relevant stakeholders, which address the relevant organisational and individual factors in a hospital setting. The aim of the present project will be; to benchmark the organisational and individual factors that impact on quality of care and patient safety, and design bottom-up interventions that both increase quality of care and physician well being. In specific the project has the following objectives: (1) To profile the specific factors of hospital-organisational culture that increase burnout among physicians, and therefore decrease quality of care, (2) To monitor burnout and its associations to quality of hospital care among physicians, (3) To identify appropriate bottom-up solutions to the problems of organisational culture and physician burnout, and its impact upon patient safety and quality of care, and (4) To develop a network for hospital managers and associated stakeholders for the communication of interventions aimed improving quality of care in hospitals. The work plan of the proposed project will consists of 3 phases: The first phase will be a preparatory one where the foundations for the following phases in terms of organisational and informational background will be outlined The second phase will assess the organisational culture, burnout and quality of care. A multi-centre survey will be conducted in physicians and patients from selected hospital-sites from South and SE Europe. This third phase will address how to improving quality of care using action research. The phase will use action research to involve health professionals and members of management boards in each hospital site to develop their own interventions for improving quality of care.

Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: KBBE.2010.2.6-01 | Award Amount: 1.17M | Year: 2011

The proposed Coordination and support actions (Coordinating, CSA) has the overall objective to disseminate state-of-the-art research results in food safety and quality topics through a series of symposia, expert working group meetings, an online platform with best practise examples and coordination of cooperation and a plan for the preparation of future activities. In addition to the aim of disseminating research results of finalised and current EC funded projects from FP6 and FP7 and other projects focusing on food safety, the consortium will develop strategies and recommendations for European policies (e.g.: food, consumers, research, health, agriculture). The secure handling of food has main impact onto the safety of food products and the European consumers. Furthermore, detailed plans and actions to foster food safety research in Europe are part of the workplan and objectives. The CSA action will pave the way for highly innovative research projects in the field of food safety. FOODSEG will connect research and policy actors in the enlarged European Union and the Candidate countries, in order to fill transitional gaps and achieve a broader network and deeper collaboration between them. The following map gives an overview of the FOODSEG consortium and the very broad network which covers nearly all regions of the enlarged European Union, Candidate countries and also third countries.

Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: INCO.2010-6.2 | Award Amount: 602.48K | Year: 2010

The objective of the JoRIEW project is to reinforce the cooperation capacities of Jordanian research centres by promoting closer scientific collaboration with a number of ERA located research centres and universities. The JoRIEW project will help structure and enhance S&T cooperation in areas of common interest, such as research system integration, integrated energy and water planning, development of water supply systems that can be powered by intermittent renewable energies, in particular flexible pumping techniques and reverse osmosis desalination technology, where joint research efforts could bring common solutions and mutual benefits. It opens a new chapter of scientific cooperation between the EC and Jordan, an important partner in the EUs neighbourhood policy. Improving Jordanian capacities in research will be achieved through following activities: Networking of Jordanian and EU research centres in view of disseminating scientific information, identifying partners and setting up joint research Developing training modules to build competency and facilitate the Jordanian participation in FP7 regarding energy and water research Developing the Jordanian research strategy for sustainable and renewable energy and water desalination in order to increase its scope, in particular its regional coverage and to improve its responses to the socio-economic needs of Jordan and other countries in the region JoRIEW project actions aim to enhance international cooperation with Jordan by including S&T capacity building (human resources, research policy, networks of researchers and research institutes) activities. Project will enable Jordanian researchers to contribute to the solution of local, regional and global problems and to economic and social development. Enhanced research capacity will also encourage researchers to compete internationally in terms of scientific excellence and increase their incentives to continue to base their research activities in Jordan.

Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: KBBE-2007-1-4-05 | Award Amount: 1.14M | Year: 2008

AgriPolicy builds on the results of the previous FP6 project CEEC AGRI POLICY ( which was awarded financial support by DG Research in 2004 following the call FP6-2003-SSP-3. The overall objective of the proposal is to support the formulation of Community agricultural policies. AgriPolicy has 4 specific objectives: 1. Networking and information sharing The objective is to stimulate the networking and the sharing of information between organisations involved in agri-economics analysis. The networking will be stimulated through the organisation of 3 symposia and 6 workshops and the development of a dynamic web site including an up-dated directories of experts and organisations. 2. Provide scientific input for policy making The objective is to provide analyses on a number of specific topics (8-monthly as well as report on demand). 3. Prepare future analysis The objective is to prepare for future policy and sectoral analyses and research by collecting quantitative and qualitative information. In the NMS, 3 monitoring reports of agricultural and rural will be prepared. In the WBC, a study on the existing availability of key agricultural and rural statistics will be prepared. 4. Develop analytical capacities The objective is to strengthen the analytical capabilities of the research organisations involved in the project in the field of policy evaluation and foresight analysis. This will be achieved by implementing training sessions as well as conducting pilot studies. AgriPolicy will be implemented by a team of experts from 24 organisations from 24 countries. The team is composed of the partners of the former project, augmented with new competencies from the old Member States (IAMO in Germany and LEI in the Netherlands), from Malta and from Albania, FYROM, Kosovo and Montenegro.

Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: SiS.2011.1.3.1-1 | Award Amount: 699.02K | Year: 2012

SERSCIDA is designed as a strategic project for supporting the cooperation and exchange of knowledge between the EU countries associated within the Council of European Social Sciences Data Archives (CESSDA) and the Western Balkan Countries (WBC) in the field of social science data archiving. The project addresses the issues of potentials of usage of information-communication technologies for the benefits of scientific research and exchange of knowledge as laid down in the call for proposals topic. The project aims to produce tangible results and improve the capacities for exchange of knowledge and data collected through research in social sciences between the European countries and WBC involved.

Agency: Cordis | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-2013-IAPP | Award Amount: 1.42M | Year: 2015

Government agencies, the public and private sectors and professional engineering sectors across Europe need to come together and proactively meet the challenge of creating a climate resilient infrastructure system. Managing National Infrastructure requires collaboration, planning and sharing of information between multiple sectors. This will reduce the risk of economic disruption to Europe and enable opportunities from well-managed infrastructure to be maximised. Adapting to climate change is not all about managing risks, it is about taking the opportunities it presents to develop innovative systems and services which are robust, efficient and valuable. The continual inspection, assessment and maintenance of bridges requires a multidisciplinary approach. Bridge inspection systems must have a knowledge and appreciation of structural engineering, geotechnics, hydraulics, hydrology, materials and transport management. BRIDGE-SMS will couple state-of-the art scientific knowledge in hydrology and river engineering with industrial knowledge in infrastructure management and web based bridge management systems to develop an open source cloud based intelligent decision support system for the assessment and management of the hydraulic vulnerability of bridges over water. This will be achieved through the secondment of staff and transfer of knowledge and skills between experts from UCC and UNIZAG (internationally renowned experts in the areas of hydrology and river engineering), NIVAS (experts in IT Systems Integration). Investing in engineering efforts to develop a system like BRIDGE-SMS to protect infrastructure is essential both to minimise risks to valuable assets, the public and the economy and to maximise opportunities to develop cost-effective and marketable solutions which can be applied to multiple sectors.

Agency: Cordis | Branch: H2020 | Program: IA | Phase: BIOTEC-3-2014 | Award Amount: 9.25M | Year: 2015

C-C bond forming reactions are at the heart of industrial organic synthesis, but remain largely unexplored due to long development timelines and the lack of broad biocatalytic reaction platforms. CARBAZYMES addresses these challenges by assembling an interdisciplinary and intersectoral consortium as a powerful synergistic tool to promote innovation in the field of biocatalytic C-C bond formation at large scale, and thus the global competitiveness of the European chemical and pharmaceutical industry. The proposed consortium, with 50% industrial participation, represents academia but also commercial interests in different stages of the research-to-market process. This top-down approach, together with a life-cycle innovation approach ensures an industrial drive to the project. Clearly aligned with the scope of topic BIOTEC3-2014, CARBAZYMES will pursue the biocatalytic synthesis (spanning TRLs 5-7) of 4 APIs and 3 bulk chemicals corresponding to market needs detected by the industrial partners in the Consortium. This will be accomplished through an inter-disciplinary approach which includes: i) a broad platform of 4 types of unique C-C bond-forming enzymes, mostly lyases; ii) the capacity to rapidly evolve enzymes to operate under industrial conditions by means of novel enzyme panels and massive screening methods; iii) application of microreactor technology for bioprocess characterization; iv) demonstration actions comprising technical (up to 100L) and economic viability studies carried out by industrial partners. CARBAZYMES unmistakably aims to have social and economic impact by addressing markets worth bn , developing enzyme evolution technologies beyond the state of the art and creating qualified jobs and technical-scale facilities at the industrial partners sites. CARBAZYMES will also achieve an environmental impact by enforcing that the developed processes replace more energy and resource intensive processes, thus leading to reduced environmental footprints.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: SSH.2012.5.1-1 | Award Amount: 8.43M | Year: 2013

The European Court of Justice expects European citizenship to become the fundamental status of nationals of the Member States. It lies at the heart of the European integration process. The treaties, legislation, and case law have given Europeans an increasing number of rights. Yet the European Commission complains that these remain underused. Therefore, it has included in FP7 a call for a large-scale IP, identifying and analyzing barriers to exercising such European citizenship rights. Utrecht University is initiating a response to this call. In its project proposal it identifies research questions and several categories of potential hindrances as answers to some of them: contradictions between different rights, multilevel rights, and differences in priorities Member States accord these rights; differences in political, administrative, and legal institutions; financial restraints; lack of sufficient solidarity; administrative and bureaucratic hurdles; language problems; and other practical barriers to claiming and exercising rights - and related duties. Furthermore we distinguish citizenship rights by the types of rights - economic, social, political, and civil - and by the ascribed characteristics of the subjects of these rights: male and female, young and old, native and immigrant. We believe multidisciplinarity will help in identifying and analyzing barriers to the exercise of European citizenship. We can learn from other times and places; therefore we add a historical and comparative dimension to the analysis. And we aim to combine insights from the historical, legal, and social sciences. Overall we want to investigate the options for a multilayered citizenship true to the EUs motto In Varietate Concordia. The research questions and theoretically identified barriers will be investigated in 12 different work packages, each containing specific research objectives, tasks, roles of the participants, and deliverables

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SEC-2012.4.1-2 | Award Amount: 4.33M | Year: 2013

Complex emergencies such as earthquakes, flooding, bombings, and the recent massacre in Utya (Norway) can seriously affect entire populations and rip nations apart, with long-term psychosocial consequences impacting the most vulnerable as well as the helpers for years following the disaster. A large number of high quality European guidelines and tools for psychosocial support interventions in crisis management already exist and have been developed during the last two decades. OPSIC will build on this work by identifying gaps and assessing best practices and develop a new innovative comprehensive operational guidance system (OGS), which will serve as the operational interface between the existing guidelines and the practical intervention tools and methods. This interface is currently missing and hinders the effective operationalization of and compliance with the guidelines in practice. Based on new research and analysis of PSS guidelines, best practices and the long-term psychosocial impact of crisis, OPSIC will design and develop an web based comprehensive operational guidance system that will operate as a common shared platform and single point of reference for PSS in crisis management. The OGS will be validated through simulations tests in three countries with crisis managers, first responders, volunteers and possible victims and evaluated according to selected key performance indicators. Subsequently, the OGS will be demonstrated for a governmental end-user and a road map for implementation of the OGS into the end-user protocols will be prepared. For the development of the guidance system, OPSIC will focus on all four phases of crisis management; prevention, preparedness, response and recovery, and relate these to the following target groups; - crisis managers, intervention forces, first responders, volunteers, victims and indirectly affected community. The expected impact of the project is in accordance with the call to improve psychosocial preparedness of the

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-10-2014 | Award Amount: 6.00M | Year: 2015

The emergence of highly diverse resistance mechanisms among pathogens requires their detailed analysis to guarantee an efficient medical treatment. The gold standard in clinical diagnostics is based on the cultivation of bacteria and their phenotypical characterisation. However, these methods are labour-intensive and time-consuming lasting in some cases up to a few weeks. Thus, faster diagnostic techniques are necessary to ensure an immediate and targeted treatment of the patient. DNA-based diagnostics can provide the relevant results within a few hours. The requirements for a clinical DNA-based characterisation method are high; more than 1000 clinically relevant antibiotic resistance genes, a few hundred phylogenetic marker genes and virulence factors have to be targeted (including SNP detection). The limit of detection has to be low because a few 100 bacterial cells in the blood system can lead to the death of the patient. It should be possible to analyse a wide range of clinical sample origins such as stool, blood, urine and saliva using the same test. In addition, the results have to be obtained within a single working day. In our project, we will develop two diagnostic systems that can be with direct sample material from patients. Thus, the time-consuming cultivation of pathogens will be avoided. Additionally, the test will be more sensitive, specific and faster than any other test on the market using an innovative DNA probe concept.

Agency: Cordis | Branch: FP7 | Program: BSG-SME-AG | Phase: SME-2 | Award Amount: 2.64M | Year: 2009

FLOCK-REPROD will provide the European dairy goat industry with the innovative, economically and environmentally-viable technology necessary to enable the hormone-free production of goats milk and related products (e.g. cheese). It will achieve this by controlling reproduction via artificial insemination (AI) all year round. FLOCK-REPROD technology will allow the EU dairy goat industry to operate in full conformity with EC regulation (96/22/EC) which restricts the use of exogenous hormones (currently used by the majority of dairy goat breeders using AI) and which will be reinforced more strictly in the very near future. In this manner, FLOCK-REPROD will ensure the future sustainability of the industry from both an economical and ecological perspective. FLOCK-REPROD will enable the EU dairy goat industry to respond to the growing demand for goat-milk products including organic goat-milk products via a consistent supply of hormone-free goats milk all year round.

Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: KBBE-2008-1-2-07 | Award Amount: 1.17M | Year: 2009

The project first assesses the state of the art of SRF as a biofuel source in CDM and JI countries (wp1) focuses on CDM countries (wp2) and links the project to current European and non-European R&D-activities in the area (wp3). Main outputs: 1) SRF guidelines and standards for land use management (wp4) for farmers and European JI/CDM project developers as well as stakeholders from the energy and biomass sector (electric utilities, pulp & paper, fibreboard etc.) 2) a SRF R&D agenda (wp5) for researchers and industry (boiler, oven, chipper, press producers etc.)

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.4.2 | Award Amount: 4.75M | Year: 2012

The goal of the X-LIKE project is to develop technology to monitor and aggregate knowledge that is currently spread across global mainstream and social media, and to enable cross-lingual services for publishers, media monitoring and business intelligence.In terms of research contributions, the aim is to combine scientific insights from several scientific areas to contribute in the area of cross-lingual text understanding. By combining modern computational linguistics, machine learning, text mining and semantic technologies we plan to deal with the following two key open research problems:- to extract and integrate formal knowledge from multilingual texts with cross-lingual knowledge bases, and- to adapt linguistic techniques and crowdsourcing to deal with irregularities in informal language used primarily in social media.As an interlingua, knowledge resources from Linked Open Data cloud ( will be used with special focus on general common sense knowledge base CycKB ( For the languages where no required linguistic resources will be available, we will use a probabilistic interlingua representation trained from a comparable corpus drawn from the Wikipedia.The solution will be applied on two case studies, both from the area of news. For the Bloomberg case study the domain will be financial news, while for the Slovenian Press Agency we will deal with general news. The technology developed in the project will be used to introduce cross-lingual and information from social media in services for publishers and end-users in the area of summarization, contextualization, personalization, and plagiarism detection. Special attention will be paid to analysing news reporting bias from multilingual sources. The developed technology will be language-agnostic, while within the project we will specifically address English, German, Spanish, and Chinese as major world languages and Catalan and Slovenian as minority languages.

Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: AAT.2008.7.0.10. | Award Amount: 2.09M | Year: 2010

The AirTN ERA-Net was established under FP6 as a network of Member States whose ministries and agencies manage public funded national research activities and programmes in Aeronautics and Air Transport. The results from AirTN in FP6 are prerequisites for the implementation of joint activities to enhance co-operation and coordination of national and regional research programmes. AirTN in FP7 will strengthen this coordination and strive for long lasting co-operation. It will bring added value to the foundation of the European Research Area and the development of a European Research Policy, especially in relation to aeronautics and air transport. The focus will be on the Implementation of Joint Activities and the funding of transnational research. The governing objective of all AirTN activities is to continue strengthening the European Research Area within the framework of the ACARE Strategic Research Agenda.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: MG-2.1-2014 | Award Amount: 3.92M | Year: 2015

The project provides solutions for common infrastructure problems encountered in diverse regions of Europe, e.g. deterioration and scour damage to bridges, slope instability, damage to switches and crossings and track performance. Whilst similar failure modes are seen around the EU, the triggers (precipitation, earthquake loading etc.) are regional. The DESTination RAIL project will develop management tools based on scientific principles for risk assessment using real performance measurements and other vital data stored in an Information Management System. This will allow for a step-change in the management of European rail infrastructure. The objectives will be achieved through a holistic management tool based on the FACT (Find, Analyse, Classify, Treat) principle. Find - Improved techniques for the assessment of existing assets will be developed. Analyse - Advanced probabilistic models fed by performance statistics and using databases controlled by an information management system. Classify - The performance models will allow a step-change in risk assessment, moving from the current subjective (qualitative) basis to become fundamentally based on quantifiable data. Treat - The impact of proposed remediation or reconstruction will be assessed using the a probabilistic whole life cycle model which includes financial and environmental costs and the impact of work on traffic flow. The FACT principles will be implemented in a holistic decision support tool for infrastructure managers. DESTination RAIL will result significant impact in relation to the objectives of the work programme. It will reduce the cost of investment by using the IMS to manage the network, (ii) Monitoring and real-times analyses will prevent unnecessary line restrictions and closures. (iii) Lower maintenance costs by optimisimg interventions in the life cycle of the asset and (iv) optimise traffic flow in the network.

News Article | November 14, 2016

Our future is likely to rely on many 'systems of systems' - networks of technical operations, that work independently, but need to act together. Creating conditions for all sorts of systems to work together could be the next step in optimising technological efficiency. Ending in September 2016, the EU-funded DYMASOS (Dynamic Management of Physically Coupled Systems of Systems) project has developed new management methods and engineering tools for these 'cyber-physical' systems of systems. Improved management leads to better performance and could significantly reduce our consumption of resources and carbon footprints. 'The project has made an important contribution in taking first concrete steps into realising and concretising a novel field of research - the Internet of Things,' says Dr. Iiro Harjunkoski, from ABB Corporate Research in Germany and a member of the DYMASOS consortium. This will enable everyday objects to be networked via the internet, allowing them to send and receive data and giving any system the capacity to be 'smart' and coordinate with other systems. DYMASOS was based on real industrial case studies. These were underpinned by a thorough analysis of markets, industrial needs, and challenges of the industrial project partners.'The research was steered by the application cases but nonetheless also geared towards obtaining fundamental results and new insights.' explains project co-ordinator, Professor Sebastian Engell of Technische Universität Dortmund. The focus of the case studies were in the fields of chemical production, from companies, BASF and INEOS, both among the largest chemicals producers in the world, and in the operation and engineering of electric power distribution and electric vehicle charging infrastructures, using data from HEP ODS, Croatia, and AYESA, Spain. 'The realistic modelling and simulation of DYMASOS is one of the critical issues addressed by the project,' says Dr Patrick Panciatici, Scientific Advisor at RTE, France. DYMASOS developed four different approaches to modelling systems of systems. In a comparison to the behaviour of biological systems, ETH Zurich looked at understanding and controlling population behaviour. They looked, for example at modelling the overnight recharging behaviour of electric car owners, knowing only information about average population behaviour. An electric vehicle case study from the city of Malaga carried out by the University of Seville, modelled coalitional control - how to jointly optimise the behaviour of different elements in a process. TU Dortmund also modelled market-like mechanisms that try to optimise results by dynamic price-setting or constraining resources to balance supply and demand; this was applied to a petrochemical site of INEOS in Cologne and a reactor system at BASF. The University of Zagreb developed a hierarchical control model; where the grid configuration can change dynamically to minimise power losses, based on an electric distribution grid case study provided by HEP ODS. Large-scale simulations of these complex systems successfully validated the management and control algorithms produced. The DYMASOS Engineering Platform provides guidelines for the design of evolving systems of systems that can balance local autonomy and global management. DYNAMOS member, Mark Lewis, a Low Carbon Consultant at Tees Valley Unlimited, in the UK says,'the project has developed a number of practical demonstrations which will interest other complexes within and across companies and organisations to start to take further interest.' Industrial project members are now implementing the solutions developed by DYMASOS and this will give European operators of large technical systems and providers of management and automation solutions strategic competitive advantages, including cost savings, energy efficiency, higher stability and improved resilience to faults and changes in demand. Explore further: Solutions for an Internet of energy

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: SEC-2011.1.3-3 | Award Amount: 19.77M | Year: 2012

Clearing large civilian areas from anti-personnel landmines and cluster munitions is a difficult problem because of the large diversity of hazardous areas and explosive contamination. A single solution does not exist and many mine action actors have asked for a toolbox from which they could choose the tools best fit to a given situation. Some have built their own toolboxes, usually specific to some precise tasks, such as clearance. The TIRAMISU project aims at providing the foundation for a global toolbox that will cover the main mine action activities, from the survey of large areas to the actual disposal of explosive hazards, including mine risk education. The toolbox produced by the project will provide mine action actors with a large set of tools, grouped into thematic modules, that will help them do their job. These tools will have been designed with the help of end-users and validated by them in mine affected countries. To reach the level of expertise needed the TIRAMISU team includes organisations that were involved in some of the most important European and international research projects in mine action of the last fifteen years. The TIRAMISU partners will build on their past experience of this topic, their long tradition to work with each other, and the strong links they have forged over the years with mine action centres and mine action authorities, demining companies and non-governmental organisations, to bring a toolbox that will represent a step forward in mine action by being the basis for a unifying, comprehensive and modular integrated solution to the clearing of large areas from explosive hazards. The philosophy of the TIRAMISU project is to concentrate most of its efforts, not on already existing technology, but on the most mature technologies and methods that are still to be fielded and on promising and innovating solutions even if they may require more work to be fielded

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SFS-20-2015 | Award Amount: 6.91M | Year: 2016

Strength2Food is a 5-year, 6.9 million project to improve the effectiveness of EU food quality schemes (FQS), public sector food procurement (PSFP) and to stimulate Short Food Supply Chains (SFSC) through research, innovation and demonstration activities. Our 30-partner consortium representing 11 EU and 4 non-EU countries combines leading academic, communication, SME and stakeholder organisations to ensure a multi-actor approach. It will undertake case study-based quantitative research to measure economic, environmental and social impacts of FQS, PSFP and SFSC. The impact of PSFP policies on balanced nutrition in schools will also be assessed. Primary research will be complemented by advanced econometric analysis of existing datasets to determine impacts of FQS and SFSC participation on farm performance and survival, as well as understand price transmission and trade patterns. Consumer knowledge, confidence in, valuation and use of FQS labels and products will be assessed via cross-national survey, ethnographic and virtual supermarket-based research. Lessons from the research will be applied and verified in 6 pilot initiatives, focusing on less-developed and transition regions. These initiatives bring together academic and non-academic stakeholder partners in action research. The six pilot actions are: a school meals initiative to improve the nutritional outcomes and economic benefits for local agri-food producers; in-store trials (undertaken with a grocery retailer) to upscale sales of local produce; a scheme to stimulate a sustainable SFSC that adds value to the fishing community; and pilot actions to expand regional food labelling; increase sales of FQS products in non-traditional markers; and improve returns to local producers at food fairs and farmers markets (via a smartphone app). Project impact will be maximised through a knowledge exchange platform, hybrid forums, school educational resources, a Massive Open Online Course and practitioner recommendations.

Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: INFRA-2010-1.2.1 | Award Amount: 70.14M | Year: 2010

Scientific research is no longer conducted within national boundaries and is becoming increasing dependent on the large-scale analysis of data, generated from instruments or computer simulations housed in trans-national facilities, by using e Infrastructure (distributed computing and storage resources linked by high-performance networks).\nThe 48 month EGI-InSPIRE project will continue the transition to a sustainable pan-European e-Infrastructure started in EGEE-III. It will sustain support for Grids of high-performance and high-throughput computing resources, while seeking to integrate new Distributed Computing Infrastructures (DCIs), i.e. Clouds, SuperComputing, Desktop Grids, etc., as they are required by the European user community. It will establish a central coordinating organisation,, and support the staff throughout Europe necessary to integrate and interoperate individual national grid infrastructures. will provide a coordinating hub for European DCIs, working to bring existing technologies into a single integrated persistent production infrastructure for researchers within the European Research Area.\nEGI-InSPIRE will collect requirements and provide user-support for the current and new (e.g. ESFRI) users. Support will also be given for the current heavy users as they move their critical services and tools from a central support model to ones driven by their own individual communities. The project will define, verify and integrate within the Unified Middleware Distribution, the middleware from external providers needed to access the e-Infrastructure. The operational tools will be extended by the project to support a national operational deployment model, include new DCI technologies in the production infrastructure and the associated accounting information to help define EGIs future revenue model.

Agency: Cordis | Branch: FP7 | Program: | Phase: | Award Amount: 3.21M | Year: 2008

eInfrastructure in Europe has reached a mature state where the GEANT network forms a backbone on top of which a distributed computing infrastructure - the Grid - provides processing and storage services for eScience research. The South-East European eInfrastructure initiatives are committed to ensuring equal participation of the less-resourced countries of the region in European trends. SEEREN initiative has established a regional network and its GEANT connection and the SEE-GRID initiative the regional Grid. Hereby proposed SEE-GRID-SCI will leverage the SEE eInfrastructure to enable new scientific collaborations among SEE user communities. SEE-GRID-SCI will stimulate widespread integrated eInfrastructure uptake by new cross-border user groups extending over the region, fostering collaboration and providing advanced capabilities to more researchers, with an emphasis on strategic groups in seismology, meteorology and environmental protection. The initiative thus aims to have a catalytic and structuring effect on a variety of user communities that currently do not directly benefit from the available eInfrastructures. In parallel, it will enlarge the regional eInfrastructure to cater for demands of the communities: a number of new Grid clusters and countries will be added, engaging a wider range of players and expanding the provider pool. Finally, SEE-GRID-SCI will help mature and stabilise the National Grid Initiatives in the region, allowing them to join the new era of longer-term sustainable Grid infrastructure in Europe. In this context, SEE-GRID-SCI will aim to attract political and financial support for materializing the eInfrastructure vision. In longer term, SEE-GRID-SCI aspires to contribute to the stabilisation and development of South-East Europe, by easing the digital divide and stimulating eInfrastructure development and adoption by new user communities, thus enabling collaborative high-quality research across a spectrum of scientific fields.

Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: SiS-2010-1.0.1 | Award Amount: 4.56M | Year: 2011

This ambitious SiS CATALYST project seeks to identify how children can be change agents in the Science and Society relationship, and from this starting point, to indicate how they can be catalysts in the longer term solutions to the grand challenges faced by society - their future. It will contextual this in Global, European, national, regional and local arenas. The Action Plan involves refining Case Studies of replicable and scalable SiS activities for children with an associated pan European benchmarking and mutual agreement process, which will provide vehicles for strategic and political alignment, as well as shared assessment tools. These core WPs will be enriched by WPs which systematically engage three critical groups: young people, students and Key Players. The focus will be on children with ability, who are currently least likely to progress to study science in post secondary education. It will also combine the science and society agenda with the social inclusion agenda through entrepreneurship as well as considering the ethics of activities. The capturing the mutual learning will be priortised and robustly disseminating and communicating this in regional, national, European arenas and beyond, specifically targeting newcomers. The totality of the activities of the consortium will be externally evaluated and all actors will be assisted to reflect on the Partnership Learning that has occurred. This will be captured as an example of mobilising mutual learning for future European initiatives. Key to the project will be the active participation of young people, exploring their perceptions and understanding of science. Learning from them as the scientists of the future. The Action Plan will be systematically promoted in Europe and beyond, with the goal of having at least 20 Ministers for Education presenting the same certificates to children in 20 countries in the final year and a Childrens Gateway to the website of every University in the World

Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: INFRA-2007-1.2-03 | Award Amount: 49.02M | Year: 2008

A globally distributed computing Grid now plays an essential role for large-scale, data intensive science in many fields of research. The concept has been proven viable through the Enabling Grids for E-sciencE project (EGEE and EGEE-II, 2004-2008) and its related projects. EGEE-II is consolidating the operations and middleware of this Grid for use by a wide range of scientific communities, such as astrophysics, computational chemistry, earth and life sciences, fusion and particle physics. Strong quality assurance, training and outreach programmes contribute to the success of this production Grid infrastructure. \nBuilt on the pan-European network GANT2, EGEE has become a unique and powerful resource for European science, allowing researchers in all regions to collaborate on common challenges. Worldwide collaborations have extended its reach to the benefit of European science.\nThe proposed EGEE-III project has two clear objectives that are essential for European research infrastructures: to expand, optimize and simplify the use of Europes largest production Grid by continuous operation of the infrastructure, support for more user communities, and addition of further computational and data resources; to prepare the migration of the existing Grid from a project-based model to a sustainable federated infrastructure based on National Grid Initiatives. \nBy strengthening interoperable, open source middleware, EGEE-III will actively contribute to Grid standards, and work closely with businesses to ensure commercial uptake of the Grid, which is a key to sustainability. \nFederating its partners on a national or regional basis, EGEE-III will have a structuring effect on the European Research Area. In particular, EGEE-III will ensure that the European Grid does not fragment into incompatible infrastructures of varying maturity. EGEE-III will provide a world class, coherent and reliable European Grid, ensuring Europe remains at the forefront of scientific excellence.

Agency: Cordis | Branch: H2020 | Program: CSA | Phase: ERC-SUPPORT-2014 | Award Amount: 958.76K | Year: 2015

The ERC is a great success scientifically, and now wants to broaden its popular and political support. But it has a problem: Most EU citizens dont care about some Brussels agency they never heard of. The solution is in the ERCs mandate: frontier research. It has science the cutting edge variety, that can capture the imagination, change the world and stimulate curiosity. We have seen the power of a fundamental science story elsewhere, and how it can focus attention on the institution behind it: the Higgs boson and CERN. It takes high scientific achievement, great story-telling, a tight focus, creative communications and a sustained effort to build a mass following in science. We believe the ERC can achieve this to matter as the source of cool science, to students, investors, policy makers, researchers, and all citizens generally, in all 28 EU member-states and beyond. The ERC can invent science and mirror it back to society. In short, ERC = ScienceSquared. To convey this message, the ERC = ScienceSquared campaign will promote ERC projects and grantees through a cluster of innovative, popular and high quality content packages punchy videos, long-form snowfall articles, tiny Tweets, augmented reality, pop-up displays which will be adapted to a new research theme every six months. The content packages will be used in ten science museums, 34 universities, hundreds of online media channels and many other outlets covering 37 countries. These will be sustainable communication channels, which the ERC can continue using when the contract is over, targeting key audience segments: more than 40 million people. This campaign as cool as the ERC itself - will stir interest in science, raise awareness of the ERC as a science power, build broader political and societal support for the ERC and encourage grant applications from a new generation of researchers, especially in countries under-represented among ERC grantees.

Kozmar H.,University of Zagreb | Kozmar H.,University of Notre Dame
Theoretical and Applied Climatology | Year: 2010

Precise urban atmospheric boundary layer (ABL) wind tunnel simulations are essential for a wide variety of atmospheric studies in built-up environments including wind loading of structures and air pollutant dispersion. One of key issues in addressing these problems is a proper choice of simulation length scale. In this study, an urban ABL was reproduced in a boundary layer wind tunnel at different scales to study possible scale effects. Two full-depth simulations and one part-depth simulation were carried out using castellated barrier wall, vortex generators, and a fetch of roughness elements. Redesigned "Counihan" vortex generators were employed in the part-depth ABL simulation. A hot-wire anemometry system was used to measure mean velocity and velocity fluctuations. Experimental results are presented as mean velocity, turbulence intensity, Reynolds stress, integral length scale of turbulence, and power spectral density of velocity fluctuations. Results suggest that variations in length-scale factor do not influence the generated ABL models when using similarity criteria applied in this study. Part-depth ABL simulation compares well with two full-depth ABL simulations indicating the truncated vortex generators developed for this study can be successfully employed in urban ABL part-depth simulations. © Springer-Verlag 2009.

Borrelli F.,University of California at Berkeley | Baotic M.,University of Zagreb | Pekar J.,Honeywell | Stewart G.,Honeywell
Automatica | Year: 2010

Finite-time optimal control problems with quadratic performance index for linear systems with linear constraints can be transformed into Quadratic Programs (QPs). Model Predictive Control requires the on-line solution of such QPs. This can be obtained by using a QP solver or evaluating the associated explicit solution. The objective of this note is twofold. First, we shed some light on the computational complexity and storage demand of the two approaches when an active set QP solver is used. Second, we show the existence of alternative algorithms with a different tradeoff between memory and computational time. In particular, we present an algorithm which, for a certain class of systems, outperforms standard explicit solvers both in terms of memory and worst case computational time. © 2010 Elsevier Ltd. All rights reserved.

Khan E.,University Paris - Sud | Paar N.,University of Zagreb | Vretenar D.,University of Zagreb
Physical Review C - Nuclear Physics | Year: 2011

Low-energy strength is predicted for the isoscalar monopole response of neutron-rich Ni isotopes, in calculations performed using the microscopic Skyrme HF + RPA and relativistic RHB + RQRPA models. Both models, although based on different energy density functionals, predict the occurrence of pronounced monopole states in the energy region between 10 and 15 MeV, well separated from the isoscalar giant monopole resonance. The analysis of transition densities and corresponding particle-hole configurations shows that these states represent almost-pure neutron single hole-particle excitations. Even though their location is not modified with respect to the corresponding unperturbed states, their strength is considerably enhanced by the residual interaction. The theoretical analysis predicts the gradual enhancement of low-energy monopole strength with neutron excess. © 2011 American Physical Society.

Ebran J.-P.,University Paris - Sud | Khan E.,University Paris - Sud | Pena Arteaga D.,University Paris - Sud | Vretenar D.,University of Zagreb
Physical Review C - Nuclear Physics | Year: 2011

The relativistic Hartree-Fock-Bogoliubov model for axially deformed nuclei (RHFBz) is introduced. The model is based on an effective Lagrangian with density-dependent meson-nucleon couplings in the particle-hole channel, and the central part of the Gogny force is used in the pairing channel. The RHFBz quasiparticle equations are solved by expansion in the basis of a deformed harmonic oscillator. Illustrative RHFBz calculations are performed for carbon, neon, and magnesium isotopes. The effect of explicitly including the pion field is investigated for binding energies, deformation parameters, and charge radii and has an impact on the nuclei's shape. © 2011 American Physical Society.

Ebran J.-P.,CEA DAM Ile-de-France | Khan E.,University Paris - Sud | Niksic T.,University of Zagreb | Vretenar D.,University of Zagreb
Physical Review C - Nuclear Physics | Year: 2014

The role of saturation for cluster formation in atomic nuclei is analyzed by considering three length-scale ratios and performing deformation-constrained self-consistent mean-field calculations. The effect of clusterization in deformed light systems is related to the saturation property of the internucleon interaction. The formation of clusters at low nucleon density is illustrated by expanding the radius of O16 in a constrained calculation. A phase diagram shows that the formation of clusters can be interpreted as a hybrid state between the crystal and the liquid phases. In the hybrid cluster phase the confining potential attenuates the delocalization generated by the effective nuclear interaction. © 2014 American Physical Society.

Matkovic Z.,CIBER ISCIII | Matkovic Z.,University of Zagreb | Miravitlles M.,CIBER ISCIII
Respiratory Medicine | Year: 2013

Microorganisms, particularly bacteria, are frequently found in the lower airways of COPD patients, both in stable state and during exacerbations. The host-pathogen relationship in COPD is a complex, dynamic process characterised by frequent changes in pathogens, their strains and loads, and subsequent host immune responses. Exacerbations are detrimental events in the course of COPD and evidence suggests that 70% may be caused by microorganisms. When considering bacterial exacerbations, recent findings based on molecular typing have demonstrated that the acquisition of new strains of bacteria or antigenic changes in pre-existing strains are the most important triggers for exacerbation onset. Even in clinically stable COPD patients the presence of microorganisms in their lower airways may cause harmful effects and induce chronic low-grade airway inflammation leading to increased exacerbation frequency, an accelerated decline in lung function and impaired health-related quality of life. Besides intraluminal localisation in the distal airways, bacteria can be found in the bronchial walls and parenchymal lung tissue of COPD patients. Therefore, the isolation of pathogenic bacteria in stable COPD should be considered as a form of chronic infection rather than colonisation. This new approach may have important implications for the management of patients with COPD. © 2012 Published by Elsevier Ltd.

JeZid M.,University of Zagreb | Krstin L.,Josip Juraj Strossmayer University of Osijek | Rigling D.,Swiss Federal Institute of forest | Durkovid-Perica M.,University of Zagreb
Molecular Ecology | Year: 2012

The ascomycete fungus Cryphonectria parasitica is an aggressive introduced pathogen of sweet chestnut (Castanea sativa Mill.). It has spread throughout the chestnut-growing areas of Europe, with higher diversity in the regions close to its first introduction and lower diversity in its expanding ranges in Europe. To reconstruct the invasion events that could explain the high diversity of C. parasitica in Croatia and Slovenia, 180 samples were genotyped using 11 sequence-characterized amplified region markers. Eight of 11 loci were found to be polymorphic, and a total of 66 different haplotypes were identified. Bayesian clustering indicated the existence of two clusters, which suggests two separate introductions of C. parasitica in these regions. The first cluster is dominant in western parts of Croatia and Slovenia and the second in eastern and northern regions. The data analysis indicates that northern Italy was the first source of infection, with the subsequent introduction from south-eastern Europe, which contributed significantly to the diversity of the C. parasitica populations tested. Most haplotypes were probably derived through sexual recombination between a few divergent haplotypes, which suggests that multiple introductions and sexual reproduction are important for the formation of genetically diverse C. parasitica populations. © 2011 Blackwell Publishing Ltd.

Pinto S.,University of Zagreb | Vlahovicek K.,University of Zagreb | Buratti E.,International Center for Genetic Engineering and Biotechnology
Human Mutation | Year: 2011

TDP-43 is a multifunctional RNA-binding protein found to be a major protein component of intracellular inclusions found in neurodegenerative disorders such as Fronto Temporal Lobar Degeneration, Amyotrophic Lateral Sclerosis, and Alzheimer Disease. PRO-MINE (PROtein Mutations In NEurodegeneration) is a database populated with manually curated data from the literature regarding all TDP-43/TDP43/TARDBP gene disease-associated mutations identified to date. A web server interface has been developed to query the database and to provide tools for the analysis of already reported or novel TDP-43 gene mutations. As is usually the case with genetic association studies, assessing the potential impact of identified mutations is of crucial importance, and in order to avoid prediction biases it is essential to compare the prediction results. However, in most cases mutations have to be submitted separately to various prediction tools and the individual results manually merged together afterwards. The implemented web server aims to overcome the problem by providing simultaneous access to several prediction tools and by displaying the results into a single output. Furthermore, the results are displayed together in a comprehensive output for a more convenient analysis and are enriched with additional information about mutations. In addition, our web server can also display the mutation(s) of interest within an alignment of annotated TDP-43 protein sequences from different vertebrate species. In this way, the degree of sequence conservation where the mutation(s) occur can be easily tracked and visualized. © 2010 Wiley-Liss, Inc.

Ebran J.-P.,CEA DAM Ile-de-France | Khan E.,University Paris - Sud | Niksic T.,University of Zagreb | Vretenar D.,University of Zagreb
Physical Review C - Nuclear Physics | Year: 2013

Using the framework of nuclear energy density functionals we examine the conditions for single-nucleon localization and formation of cluster structures in finite nuclei. We propose to characterize localization by the ratio of the dispersion of single-nucleon wave functions to the average internucleon distance. This parameter generally increases with mass and describes the gradual transition from a hybrid phase in light nuclei, characterized by the spatial localization of individual nucleon states that leads to the formation of cluster structures, toward the Fermi liquid phase in heavier nuclei. Values of the localization parameter that correspond to a crystal phase cannot occur in finite nuclei. Typical length and energy scales in nuclei allow the formation of liquid drops, clusters, and halo structures. © 2013 American Physical Society.

Zarzycki P.,Pacific Northwest National Laboratory | Chatman S.,Pacific Northwest National Laboratory | Preocanin T.,University of Zagreb | Rosso K.M.,Pacific Northwest National Laboratory
Langmuir | Year: 2011

Reaction rates of environmental processes occurring at hydrated mineral surfaces are in part controlled by the electrostatic potential that develops at the interface. This potential depends on the structure of exposed crystal faces as well as the pH and the type of ions and their interactions with these faces. Despite its importance, experimental methods for determining fundamental electrostatic properties of specific crystal faces such as the point of zero charge are few. Here we show that this information may be obtained from simple, cyclic potentiometric titration using a well-characterized single-crystal electrode exposing the face of interest. The method exploits the presence of a hysteresis loop in the titration measurements that allows the extraction of key electrostatic descriptors using the Maxwell construction. The approach is demonstrated for hematite (α-Fe2O3) (001), and thermodynamic proof is provided for the resulting estimate of its point of zero charge. Insight gained from this method will aid in predicting the fate of migrating contaminants, mineral growth/dissolution processes, and mineral-microbiological interactions and in testing surface complexation theories. © 2011 American Chemical Society.

Bjazic T.,University of Zagreb | Ban Z.,University of Zagreb | Milanovicb M.,University of Maribor
Journal of Power Sources | Year: 2012

This paper presents the derivation of a linear model with changeable parameters of constant frequency peak current mode controlled DC/DC boost converter supplied by a PEM fuel cell stack. The derived model has the same structure irrespective of the conduction mode and therefore, it is suitable for design of simple and advanced controllers of the output voltage. Experimental results on the system with 450 W boost converter supplied by PEM fuel cell emulator show that the derived model accurately describes the system in a given operating point, determined by the load resistance or output current. © 2011 Elsevier B.V. All rights reserved.

Simic Z.,University of Zagreb | Havelka J.G.,University of Zagreb | Bozicevic Vrhovcak M.,DOOR Society for Sustainable Development Design
Renewable Energy | Year: 2013

The paper provides an analysis of small wind turbines with less than 10 kW of installed power. Power curves are compared and analyzed for a number of different wind turbines. Furthermore, the possible electricity production is assessed for all of them with their different power curves, same pole heights and wind characteristics using a multiannual array of data measured at a location in Croatia. The impact of the shape of the power curve, together with the turbine rated power relative to its swept area, on the total electricity production and generated income is analyzed and discussed. Results indicate much larger ranges of both potential electricity production and the cost of electricity than expected. © 2012 Elsevier Ltd.

Benic S.,University of Zagreb | Blaschke D.,Wrocław University | Blaschke D.,Joint Institute for Nuclear Research | Buballa M.,TU Darmstadt
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2012

We show that the Cornwall-Jackiw-Tomboulis thermodynamic potential of dynamical quark models with a quark propagator represented by complex conjugate mass poles inevitably exhibits thermodynamic instabilities. We find that the minimal coupling of the quark sector to a Polyakov loop potential can strongly suppress but not completely remove such instabilities. This general effect is explicitly demonstrated in the framework of a covariant, chirally symmetric, effective quark model. © 2012 American Physical Society.

Laken B.A.,Institute Astrofsica Of Canarias | Laken B.A.,University of La Laguna | Calogovic J.,University of Zagreb
Journal of Space Weather and Space Climate | Year: 2013

The composite (superposed epoch) analysis technique has been frequently employed to examine a hypothesized link between solar activity and the Earth's atmosphere, often through an investigation of Forbush decrease (Fd) events (sudden high-magnitude decreases in the flux cosmic rays impinging on the upper-atmosphere lasting up to several days). This technique is useful for isolating low-amplitude signals within data where background variability would otherwise obscure detection. The application of composite analyses to investigate the possible impacts of Fd events involves a statistical examination of time-dependent atmospheric responses to Fds often from aerosol and/or cloud datasets. Despite the publication of numerous results within this field, clear conclusions have yet to be drawn and much ambiguity and disagreement still remain. In this paper, we argue that the conflicting findings of composite studies within this field relate to methodological differences in the manner in which the composites have been constructed and analyzed. Working from an example, we show how a composite may be objectively constructed to maximize signal detection, robustly identify statistical significance, and quantify the lower-limit uncertainty related to hypothesis testing. Additionally, we also demonstrate how a seemingly significant false positive may be obtained from non-significant data by minor alterations to methodological approaches. © B.A. Laken et al., Published by EDP Sciences 2013. © B.A. Laken et al., Published by EDP Sciences 2013.

Laken B.A.,Institute of Astrophysics of Canarias | Laken B.A.,University of La Laguna | Calogovic J.,University of Zagreb
Geophysical Research Letters | Year: 2011

Although over centennial and greater timescales solar variability may be one of the most influential climate forcing agents, the extent to which solar activity influences climate over shorter time periods is poorly understood. If a link exists between solar activity and climate, it is likely via a mechanism connected to one (or a combination) of the following parameters: total solar irradiance (TSI), ultraviolet (UV) spectral irradiance, or the galactic cosmic ray (GCR) flux. We present an analysis based around a superposed epoch (composite) approach focusing on the largest TSI increases and decreases (the latter occurring in both the presence and absence of appreciable GCR reductions) over daily timescales. Using these composites we test for the presence of a robust link between solar activity and cloud cover over large areas of the globe using rigorous statistical techniques. We find no evidence that widespread variations in cloud cover at any tropospheric level are significantly associated with changes in the TSI, GCR or UV flux, and further conclude that TSI or UV changes occurring during reductions in the GCR flux are not masking a solar-cloud response. However, we note the detectability of any potential links is strongly constrained by cloud variability. Copyright 2011 by the American Geophysical Union.

Resman M.,University of Zagreb | Resman M.,University of Burgundy
Nonlinearity | Year: 2014

In this article, we study the analyticity of (directed) areas of ε-neighbourhoods of orbits of parabolic germs. The article is motivated by the question of analytic classification using ε-neighbourhoods of orbits in the simplest formal class. We show that the coefficient in front of the ε2 term in the asymptotic expansion in ε, which we call the principal part of the area, is a sectorially analytic function in the initial point of the orbit. It satisfies a cohomological equation similar to the standard trivialization equation for parabolic diffeomorphisms. We give necessary and sufficient conditions on a diffeomorphism f for the existence of a globally analytic solution of this equation. Furthermore, we introduce a new classification type for diffeomorphisms implied by this new equation and investigate the relative position of its classes with respect to the analytic classes. © 2014 IOP Publishing Ltd & London Mathematical Society.

Zuzak I.,University of Zagreb | Schreier S.,University of Hagen
IEEE Internet Computing | Year: 2012

A key challenge in developing RESTful Web systems is the lack of software development frameworks that support REST principles. This article gives practical guidelines for designing frameworks for developing such systems. Derived from intuitive formal models, these guidelines enable a development process that improves separation of concerns and the modifiability of developed systems. The authors analyze several existing Web frameworks to determine how well they correspond to these guidelines © 1997-2012 IEEE.

Nomura K.,French Atomic Energy Commission | Vretenar D.,University of Zagreb | Niksic T.,University of Zagreb | Lu B.-N.,Jülich Research Center
Physical Review C - Nuclear Physics | Year: 2014

A systematic analysis of low-lying quadrupole and octupole collective states is presented based on the microscopic energy density functional framework. By mapping the deformation constrained self-consistent axially symmetric mean-field energy surfaces onto the equivalent Hamiltonian of the sdf interacting boson model (IBM), that is, onto the energy expectation value in the boson condensate state, the Hamiltonian parameters are determined. The study is based on the global relativistic energy density functional DD-PC1. The resulting IBM Hamiltonian is used to calculate excitation spectra and transition rates for the positive- and negative-parity collective states in four isotopic chains characteristic for two regions of octupole deformation and collectivity: Th, Ra, Sm, and Ba. Consistent with the empirical trend, the microscopic calculation based on the systematics of β2-β3 energy maps, the resulting low-lying negative-parity bands and transition rates show evidence of a shape transition between stable octupole deformation and octupole vibrations characteristic for β3-soft potentials. © 2014 American Physical Society.

Satovic D.,Academy of Fine Arts | Martinez S.,University of Zagreb | Bobrowski A.,AGH University of Science and Technology
Talanta | Year: 2010

An overview of the electrochemical method for the identification of microsampled corrosion products from historical and archaeological bronzes is reported. Two characteristic examples of long-term air and subterranean formed patinas and two artificial patinas formed on Cu-6%Sn bronze in sulphate and chloride solutions, were investigated in 0.1 M HCl(aq) by means of the cyclic voltammetry of micro-particles attached to a carbon paste electrode. Patina constituent phases were identified by comparing the electrochemical parameters of the patina samples to those of reference compounds: CuO, Cu2O, SnO, SnO2, CuCl, CuCl2 × 2H2O and CuSO4 × 5H2O. An identification scheme was suggested which may be applied to discern the various corrosion products of bronze based on electrochemical data (voltammetric peak potentials). The presence of two prevalent phases of sulphate and chloride patinas, CuSO4 and CuCl, as well as the presence of Sn compounds was clearly indicated by the cyclic voltammetry of microparticles, in both, naturally and artificially formed samples. A comparison to the ATR-FTIR results revealed that the methods are complementary and that their simultaneous application could prove particularly valuable in drawing conclusions about the current shape and prospects of the conservation and restoration of bronze artefacts. © 2010 Elsevier B.V. All rights reserved.

Kozmar H.,University of Zagreb | Kozmar H.,University of Notre Dame
Journal of Wind Engineering and Industrial Aerodynamics | Year: 2011

A modified design of the 'Counihan' vortex generator was proposed for purposes of part-depth atmospheric boundary layer (ABL) wind-tunnel simulations. Three redesigned vortex generators were manufactured and their applicability was tested in a boundary layer wind tunnel together with a castellated barrier wall and a fetch of roughness elements. Using this hardware, neutrally stratified ABL developing above rural, suburban and urban terrains was successfully reproduced. A hot-wire anemometry system was applied for measurements of mean velocity and velocity fluctuations. Comparisons of wind-tunnel results with full-scale data and/or with theoretical models are presented, including mean velocity, turbulence intensity, integral length scale of turbulence and power spectral density of velocity fluctuations. The analysis of obtained results indicates the adequacy of redesigned 'Counihan' vortex generators for part-depth ABL wind-tunnel simulations, as the obtained wind-tunnel results compare well with the full-scale rural, suburban and urban ABL. © 2010 Elsevier Ltd.

Lehmann H.,Thuringer Landessternwarte Tautenburg | Southworth J.,Keele University | Tkachenko A.,Catholic University of Leuven | Pavlovski K.,University of Zagreb
Astronomy and Astrophysics | Year: 2013

Context. KIC 10661783 is an eclipsing binary that shows δ Scuti-like oscillations. More than 60 pulsation frequencies have been detected in its light curve as observed by the Kepler satellite. Aims. We want to determine the fundamental stellar and system parameters of the eclipsing binary as a precondition for asteroseismic modelling of the pulsating component and to establish whether the star is a semi-detached Algol-type system. Methods. We measured the radial velocities of both components from new high-resolution spectra using TODCOR and compute the orbit using PHOEBE. We used the KOREL program to decompose the observed spectra into its components, and analysed the decomposed spectra to determine the atmospheric parameters. For this, we developed a new computer program for the normalisation of the KOREL output spectra. Fundamental stellar parameters are determined by combining the spectroscopic results with those from the analysis of the Kepler light curve. Results. We obtain Teff, log g, vsini, and the absolute masses and radii of the components, together with their flux ratio and separation. Whereas the secondary star rotates synchronously with the orbital motion, the primary star rotates subsynchronously by a factor of 0.75. The newly determined mass ratio of 0.0911 is higher than previously thought and means a detached configuration is required to fit the light curve. Conclusions. With its low orbital period and very low mass ratio, the system shows characteristics of the R CMa-type stars but differs from this group by being detached. Its current state is assumed to be that of a detached post-Algol binary system with a pulsating primary component. © 2013 ESO.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: KBBE-2009-1-2-01;KBBE-2009-2-3-03 | Award Amount: 3.67M | Year: 2010

The project focusses on development of novel solid food conservation techniques for a wide range of applications (frozen, dried and packaged) to extent shelf life and to meet the current need for convenient foods. Three innovative preservation techniques, partly interconnected, will be investigated for having the potential for better maintaining the product quality and freshness (nutritional value, taste) and the potential for improved sustainability, as the techniques allow for reduction of the raw material losses, lower energy costs and reductions in the use of chemicals. The environmental benefits will be established during the process and product development on the basis of sustainability indicators, applicable for wider use. After a development stage, a demonstration unit will be build for comparative validation and new product development on location, particularly intended for SME.

Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.12. | Award Amount: 10.87M | Year: 2013

EUROFLEETS2 is the enhancement of EUROFLEETS1, with the aim of developing a new pan-European distributed infrastructure with common strategic vision and coordinated access to Research Vessels (RVs) and marine equipment. EUROFLEETS2 will furthermore undertake specific actions to consolidate research fleets organization, methodology and tools through operational initiatives (like virtual fleets) leading to more interoperable and cost effective European research fleets. EUROFLEETS2 main objectives are: * Promotion of operational coordination and integration of RVs. Modern European RVs are made accessible under EUROFLEETS2 (8 of Ocean/Global class and 14 of Regional class) plus 6 mobile pieces of equipment. Further integration is proposed within an innovative multi-platform experiment. The corresponding call aims to identify a flagship proposal, with a proven scientific excellence; * Completion of strategic perspectives for the European research fleets with a polar component; * Promotion of exchanges of mobile equipment on board European RVs to foster interoperability; * Enhancing the impact of research fleets on innovation by fostering the involvement of industry in specific activities, both as end user (e.g. development and testing of new equipment or deep-sea exploration for new resources) or as supplier; * Development of new training actions including a pilot floating university, and of new technological innovations to be widely used on board European RVs; * Making a new step towards a long term sustainable group of European Regional RVs with a view to applying for its insertion into the ESFRI roadmap.

Agency: Cordis | Branch: H2020 | Program: CSA | Phase: HCO-17-2015 | Award Amount: 2.04M | Year: 2015

The overall aim of JPsustaiND is to support the development and extension of the capacities of the EU Joint Programming Initiative on Neurodegenerative Diseases, in particular Alzheimers (JPND). Since 2009 JPND has been operating on a very light management structure based on a simple Terms of Reference. Through this JPND has been able to set a common Strategic Research Agenda, and to deliver its first implementation plan that has allowed among other achievements, the mobilisation of approximately 100 million of additional funding between 2011 and 2015 to support transnational research programs. While progress has been pleasing to date, the implementation of JPND must now be scaled-up to further catalyse Member State commitments, and to formalize synergies between members and various partners. The immediate challenge therefore for JPND is to secure its long-term sustainability by Member States, to mobilize those which are not yet participating, and to increase its impact at the national level and globally. JPsustaiND thus aims at creating the dedicated structure responsible for long-term JPND management and implementation, and extension of JPND membership to EU Member States and other countries and initiatives not yet participating. To achieve this goal, the JPsustaiND partners, with the support of the JPND Management Board, will implement the following six workpackages: Coordination and Management; Long Term Sustainability; Capacity Extension; Alignment and Outreach; Communication and Advocacy; and Monitoring, Evaluation and Impact Assessment. JPsustaiND will implement a stronger global dimension of the JPND, and will avoid duplication of research and infrastructure investment at the national level. By supporting further coordination and integration of national research and innovation programmes with the JPND research strategy, in coherence with Horizon 2020 objectives, JPsustaiND is thus creating a dedicated European Research Area for neurodegenerative diseases.

Agency: Cordis | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2011-IRSES | Award Amount: 505.70K | Year: 2012

Project DISKNET, plans an innovative scientific exchange in the field of designing and optimising distributed networks for efficient energy supply, management and use. The sustainability in the development in the EU and worldwide depends on a number of interrelated factors, originating from the environment, the economy and the society. Sufficient and secure energy supply at acceptable cost and minimum environmental impact is key to achieving sustainability regarding all these aspects. The current proposal, addresses all the three aspects environmental, economic and societal, by proposing research and integrated knowledge management for improved efficiency of energy supply, conversion and utilisation. The objective of the proposed project is to stimulate a long term research collaboration between academic organisations from the European Research Area (ERA) (Hungary, Greece and Croatia) and leading academic partners from third countries (Ukraine, Jordan and Morocco), in the area of energy systems engineering and energy supply chains. This will be achieved by undertaking the following joint activities: Implement a well structured mobility programme of researchers through two-way exchanges Organise a series of training courses, seminars and workshops for researchers both ERA and other countries Evaluation and assessment of tools, methodologies and approaches for the design, operation, control and optimisation of energy supply chains involving distributed energy generation and polygeneration of energy and other products Organisation and joint participation in conferences Joint research involving simulation, design and feasibility studies. Cooperating with governments, energy investors and other research organisations to present the results of the joint support actions Integrated exchange and management of knowledge using modern information and communication technologies

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.1.4-2 | Award Amount: 8.33M | Year: 2011

Despite significant achievements in the field of regenerative medicine and the enormous potential for engineered tissue products, significant hurdles have prevented cellular therapies from gaining wide-spread clinical adoption. Manufacturing related issues have been proposed as key challenges to be addressed for the translation of regenerative therapies to the clinic and the successful commercialization of engineered products. Similar to other biotechnology sectors (e.g., vaccines or recombinant protein production), bioreactor systems could play a central role in establishing engineered tissues in the clinic. In fact, by automating and streamlining manufacturing processes, they would allow to improve product reproducibility, safety, standardization and possibly reach cost-effectiveness. This project aims at the development, pre-clinical and clinical testing of a sensor-based bioreactor system for the production of functional, autologous engineered grafts with reproducible properties. The bioreactor-based manufacturing paradigm will be addressed in the specific context of cartilage repair. Innovative features of the proposed tissue engineering strategy will include: (i) an automated and controlled production system, (ii) bioreactor conforming to regulatory guidelines, (iii) simplified, streamlined, and scalable tissue engineering process, (iv) on-line monitoring of culture/quality parameters, and (v) data management systems for traceability. To achieve these goals, BIO-COMET brings together internationally renowned leaders in the field of regenerative medicine, from academic, clinical and industrial research institutions. Successful implementation of the project will be instrumental to extend use of bioreactor-based platforms beyond cartilage tissue engineering, with the ultimate goal to facilitate broad utilization and commercialization of cell-based grafts as therapeutic solutions.

Skorin-Kapov N.,University of Zagreb | Chen J.,KTH Royal Institute of Technology | Wosinska L.,KTH Royal Institute of Technology
IEEE/ACM Transactions on Networking | Year: 2010

Security issues and attack management in transparent wavelength division multiplexing (WDM) optical networks have become of prime importance to network operators due to the high data rates involved and the vulnerabilities associated with transparency. Deliberate physical-layer attacks, such as high-powered jamming, can seriously degrade network performance and must be dealt with efficiently. While most approaches are focused on the developing fast detection and reaction mechanisms triggered in case of an attack, we propose a novel approach to help deal with these issues in the network planning and provisioning process as a prevention mechanism. Namely, we propose to route lightpaths in such a way as to minimize the potential damage caused by various physical-layer attacks. We present a new objective criterion for the routing and wavelength assignment (RWA) problem, which we call the maximum Lightpath Attack Radius (max LAR), and formulate the routing subproblem as an integer linear program (ILP). We test it on small networks to get an insight into its complexity and compare it to a formulation that minimizes congestion. Results indicate that our formulation achieves significantly better results for the maxLAR while obtaining near-optimal or optimal congestion in all cases. For larger networks, we propose a tabu search algorithm for attack-aware lightpath routing, in combination with an existing graph-coloring algorithm for wavelength assignment. Testing and comparing with existing approaches from literature indicate its superiority with respect to the maxLAR and average lightpath load, albeit at the expense of somewhat higher congestion. However, this is justified with the obtained improvement in network security. © 2006 IEEE.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.8.1 | Award Amount: 2.78M | Year: 2012

Embedded systems are the invisible electronics and corresponding software that bring intelligence to objects, processes and devices. The main challenge in engineering education for embedded systems at university level is a complex and multidisciplinary approach which includes understanding of various systems based on different technologies and system solution optimizations. The main idea behind the project is to provide a unified platform which will cover a complete process for embedded systems learning. A modular approach is considered for skills practice through supporting individualisation in learning. This platform shall facilitate a novel development of universal approach in creative learning environment and knowledge management that encourage use of ICT. New learning model is challenging the education of engineers in embedded systems design through real-time experiments that stimulate curiosity with ultimate goal to support students to understand and construct their personal conceptual knowledge based on experiments. In addition to the technological approach, the use of cognitive theories on how people learn will help students to achieve a stronger and smarter adaptation of the subject. Applied methodology will be evaluated from the scientific point of view in parallel with the implementation in order to feed back results to the R&D.\nAs a result, the proposed Embedded Computer Engineering Learning Platform will ensure a sufficient number of educated future engineers in Europe, capable of designing complex systems and maintaining a leadership in the area of embedded systems, thereby ensuring that our strongholds in automotive, avionics, industrial automation, mobile communications, telecoms and medical systems are able to develop. In such a manner, the E2LP intends to increase European competitiveness in the learning process of embedded computer engineering, ensuring further technological and methodological development of the educational approach in this field.

Agency: Cordis | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2014 | Award Amount: 324.00K | Year: 2015

Abnormal heart rhythms are a major cause of cardiovascular disease and death in Europe. Sudden cardiac death accounts for 50% of cardiac mortality in developed countries; ventricular tachycardia or ventricular fibrillation is the commonest underlying arrhythmia. In the ambulatory population, atrial fibrillation is the commonest one, and is associated with increased risk of stroke and heart failure, particularly in the aged population. If arrhythmias are detected at an early stage of heart disease, appropriate treatment can be effective, reducing disability and death. However, in the early stages of disease these may be transient, lasting only a few seconds, and thus difficult to detect. Current approaches to cardiac rhythm monitoring include: a) non-invasive external recording devices; which are suitable for short term (<24h) recording, and b) implantable loop recorders, which are inserted subcutaneously beneath the chest wall; capable of monitoring heart rhythm for extended periods, but there is considerable expense associated with the device, hospitalisation costs and risk of infection. The proposed joint research project through staff exchange activities, will investigate enabling technologies for non-invasive recording heart rhythm during long periods of time (>36h), using a wrist or arm wearable device with novel ECG sensing techniques and embedded real-time cardiac arrhythmia detection processes. The problem of extracting the far-field heart electrogram signal from noise components will be addressed using smart denoising algorithms. The project will impact by establishing a successful international and intersectoral partnership for the development of new technologies addressing a significant cardiovascular healthcare problem. These technologies will be suitable for integration into current e-Health and cardiac information systems, and will impact on healthcare costs reduction by improved efficiency in the diagnosis and early treatment of cardiac disease.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.6.3 | Award Amount: 3.39M | Year: 2010

The EU electric power system experiences a fundamental change in the quasi-monopolistic, top-down oriented, stable, and reasonable predictable arrangements of the past. It now spans continents, has hundreds of millions consumers and hundreds of thousands of producers, from nuclear power plants to privately-owned and operated badly predictable renewables such as solar cells, wind and microturbines and operates in an increasingly liberalized market. These developments pose huge challenges for its reliable and economic operation. This proposal focuses on the real-time power imbalance in the power net, which arises as a consequence of errors in the prediction of both production and demand. As this power imbalance will increase both in size and in frequency, presents arrangements to cope with this imbalance are no longer valid. They are neither reliable nor economic anymore. This project proposes an advanced ICT and control framework for ancillary services (reserve capacity) which allows a more intelligent solution by giving consumers and producers clear, real-time financial incentives to adapt their consumption/production according to the actual needs of the power system. This design is based on a distributed control structure, enabled by a fast ICT infrastructure and advanced control theory to reliably and economically deal with the necessary ancillary services. Decisions by consumers, producers, power exchanges and TSOs can be taken locally, based on local or national preferences and regulation. Still, the embedded incentives of the proposed framework can guarantee that all these local decisions together contribute to the global objectives of the EE power net: a reliable electric energy supply at the lowest costs.\nInstead of investing in additional expensive and environment-unfriendly reserve production or storage facilities with a low utilization rate, the reliability and economy are enforced by intelligent ICT and control.

Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: PEOPLE-2007-1-1-ITN | Award Amount: 4.07M | Year: 2008

The development and production of glycoarrays will provide the foreground knowledge necessary to lead to a step change in the diagnosis and treatment of diseases ranging from cancers to autoimmune diseases. Carbohydrates play a pivotal role in the molecular interactions that govern biological events at the centre of health and disease. This has become more evident as the characterisation and identification of proteins and their interactions through proteomics has advanced during the last decade. Whilst proteomics is providing a wealth of information, it does not deal with the results of post-translational modifications such as glycosylation which are frequently the driving force behind the biological activity of proteins. This lack of information is beginning to be addressed by the emerging field of glycomics, the mapping of all carbohydrate-protein interactions. The proposed training network is multidisciplinary involving carbohydrate chemistry, array technology and application. The programme offers young scientist an outstanding opportunity to be involved in the development stages of the glycoarray technology and apply this technology to important biological questions.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETPROACT-2-2014 | Award Amount: 3.99M | Year: 2015

subCULTron aims for achieving long-term autonomy in a learning, self-regulating, self-sustaining underwater society/culture of robots in a high-impact application area: Venice, Italy. Our heterogeneous system consists of 3 different agent types: On the sea-ground, artificial mussels are the collective long-term memory of the system, allowing information to stay beyond the runtime of other agents, thus allowing to continue learning from previously learned states. These mussels monitor the natural habitat, including biological agents like algae, bacterial incrustation and fish. On the water surface, artificial lilypads interface with the human society, delivering energy and information influx from ship traffic or satellite data. Between those two layers, artificial fish move/monitor/explore the environment and exchange info with the mussels and lilypads. Artificial mussels are a novel class of underwater agents. We aim to push forward the edge of knowledge with novel sensors (electric sense/electro-communication), novel bio-inspired algorithms (underwater hives) and novel energy harvesting in underwater scenarios. We will improve the worlds record for swarm-size in autonomous collective underwater robotics by almost one order of magnitude. Our application field is a human- and animal-co-inhabited real-world environment of high impact: Venice canals & lagoon. These habitats are highly dynamic and structured, expected to be reflected by a spatial self-structuring of our mussel population. These sub-populations locally perform memetic/ cultural learning algorithms on their specific local data. Thus our cultural evolution algorithms will promote sub-culture development, similar to the human society that does the same above the water level in parallel. Overall, we aim for an artificial society underneath the water-surface to the service of a human society above the water.

Agency: Cordis | Branch: FP7 | Program: CIP-EIP-EI-PMRP | Phase: | Award Amount: 925.10K | Year: 2012

Specific objectives: Development of a marketing strategy for the introduction of an innovative, environmentally friendly and sustainable product, Set up a mechanism to exploit across Europe, Encourage the re-use and recycling of construction and demolition waste (CDW) in order to shift CDW management from disposal to recycling and reduce utilization of natural resources thus preventing landscape degradation, Promote the substitution of conventional thermal insulation materials by mineral wool produced using innovative and sustainable technology, leading to a reduced environmental impact, Promote implementation of prefabricated, energy efficient products in order to enable reduction of primary energy consumption in residential and commercial buildings, Reduce embodied energy, embodied carbon and production of by-product wastes. ECO-SANDWICH is a ventilated prefabricated wall panel utilising recycled CDW and sustainable Ecose technology mineral wool for reduction of primary energy consumption in building stock. The concept incorporates three priorities of the eco-innovation call; it uses recycled material to create innovative sustainable building product which contributes to greening the business of SMEs through decreasing their environmental impact accompanied by the use of less non-renewable or natural resources, and energy efficiency of final products (buildings). The ECO-SANDWICH represents a significant improvement over the existing prefabricated wall panel products, aligning itself with the mandatory targets of the EU Directives targets - EPBD, its Recast EPBD II and Waste Framework Directive (recycled CDW in concrete production, mineral wool based on Ecose Technology, reduction of primary energy use in buildings where the ECO-SANDWICH is installed). Contribution to innovation of the ECO-SANDWICH project is the development of a ventilated prefabricated concrete wall panel that uses mineral wool as core insulation and modification of concreting technology.

Agency: Cordis | Branch: FP7 | Program: CSA | Phase: ICT-2009.9.4 | Award Amount: 584.98K | Year: 2010

The European antenna research received great benefits from the structuring efforts provided by the Network of Excellence ACE (2004-2007). The ACE NoE produced a long list of outstanding results, such as the Antenna Expert Groups (AEG), the European School of Antennas (ESoA), the European Conferences on Antennas and Propagation (EuCAP), the Antenna Virtual Centre of Excellence (VCE) and the European Association on Antennas and Propagation (EurAAP) joined by over 300 European institutions and 1700 researchers etc. (see\nIn this frame, the CARE Coordination Action is aimed at reinforcing the existing cooperation among the antenna research teams across Europe and provides the framework for a better collaboration among the research projects dealing with antennas and wireless technologies in Health, Transport, Security and Space applications.\nIn particular the CARE objectives are:\n\tto improve the knowledge exchange, by secondments among the AEG and in the ESoA\n\tto promote good practices in antenna software and measurements standardisation\n\tto support the dissemination, by sessions convened by the AEG in the EuCAP Conference\n\tto keep alive the Antennas Virtual Centre of Excellence for information spreading.\nMoreover, CARE will continue the existing coordination, started during ACE, with the National Societies in antenna research (CIRMA, IET, ITG, REsA, SEE, SIEm, SITEL etc.) in order to create synergies with the national research projects and to improve the European excellence in antenna research.\nThe Consortium is composed by top level institutions of the European antenna research area. Each CARE Participant will also act as the national or regional hub for the distribution of the CARE results.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRADEV-3-2015 | Award Amount: 2.50M | Year: 2015

After CESSDAs successful launch we must now achieve full European coverage, and strength and sustainability for the widened network. European coverage: In each country the barriers to, and the potential value and benefits from, membership will be examined, and existing relevant infrastructure mapped. Bespoke coordination, networking activities, and stakeholder forums, all designed to address the specific barriers, will be delivered. In particular, relationships between national ministries, Research Councils, and the social science research community will be built. Relevant work in other completed initiatives (eg. SERSCIDA, DASISH, DwB) would be taken up and moved to the next stage of practical and direct support for achieving membership of the CESSDA Research Infrastructure. National opportunities for using European structural funds and other sources of support will be explored. The approach is to ensure the national and European economic and social benefits, and the positive returns on investment, that are achieved through membership of CESSDA are wholly apparent to the relevant national decision-makers. Strength and sustainability: The widened membership must form a strong and sustained network, where global best practice is built in to the infrastructure of European social science and research. Membership of CESSDA should mean membership of a world class support infrastructure. Links with practical benefits will be established with equivalent infrastructures in other continents. The benefits of coordinated collaboration and consultation with trans-national European stakeholders (for example, Eurostat, European Parliament, Consilium) will bring benefits to all national CESSDA Members. The visibility of this research infrastructure and its importance to excellent evidence in policy making will be enhanced. Further, existing national infrastructures must complete their transition into a holistic service, capable of access services for all.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-15-2015 | Award Amount: 5.11M | Year: 2015

Spontaneous healing of articular cartilage injuries is poor and untreated defects predispose to osteoarthritis. Current therapies, including innovative autologous cell-based treatments, cannot predictably and reproducibly restore cartilage structure and function. BIOCHIP will carry out a multicenter, prospective phase II clinical trial to treat knee cartilage injuries using engineered grafts based on autologous nasal chondrocytes (NC). As compared to typically employed articular chondrocytes, NC have a higher and more reproducible capacity to generate mature cartilage tissues. Importantly, molecular/mechanical characterization, large size animal studies and a phase I trial carried out by BIOCHIP partners have already shown the compatibility of NC upon implantation in a joint, with promising preliminary clinical results. BIO-CHIPs specific objectives are: (1) To test the hypothesis that the maturation of NC-based cartilage grafts improves the clinical efficacy in the treatment of cartilage lesions (108 patients will be recruited to reach statistical significance) (2) To extend the range of clinical indications of NC-based grafts to so far untreatable pre-osteoarthritic lesions (kissing cartilage lesions in a sheep model) BIO-CHIP capitalizes on clinical experience of 4 reference centers for cartilage surgery, on established GMP manufacturing capacity and on preparation for commercial exploitation by a strong orthopedic device company. Demonstration of therapeutic efficacy of the new treatment will address a large clinical need (over 2 million cartilage defects/year worldwide), improve quality of life (reduce pain & disability in the young, delay prosthetic implants in the elderly), exploit a commercial opportunity (prospected revenues of up to 130 million /year) and reduce healthcare costs (estimated 12,000 healthcare savings/procedure). BIO-CHIP will consolidate the currently leading role of Europe in the development of cell-based cartilage regeneration strate.

News Article | August 22, 2016

When an airplane begins to move faster than the speed of sound, it creates a shockwave that produces a well-known “boom” of sound. Now, researchers at MIT and elsewhere have discovered a similar process in a sheet of graphene, in which a flow of electric current can, under certain circumstances, exceed the speed of slowed-down light and produce a kind of optical “boom”: an intense, focused beam of light. This entirely new way of converting electricity into visible radiation is highly controllable, fast, and efficient, the researchers say, and could lead to a wide variety of new applications. The work is reported today in the journal Nature Communications, in a paper by two MIT professors — Marin Soljačić, professor of physics; and John Joannopoulos, the Francis Wright Davis Professor of physics — as well as postdoc Ido Kaminer, and six others in Israel, Croatia, and Singapore. The new finding started from an intriguing observation. The researchers found that when light strikes a sheet of graphene, which is a two-dimensional form of the element carbon, it can slow down by a factor of a few hundred. That dramatic slowdown, they noticed, presented an interesting coincidence. The reduced speed of photons (particles of light) moving through the sheet of graphene happened to be very close to the speed of electrons as they moved through the same material. “Graphene has this ability to trap light, in modes we call surface plasmons,” explains Kaminer, who is the paper’s lead author. Plasmons are a kind of virtual particle that represents the oscillations of electrons on the surface. The speed of these plasmons through the graphene is “a few hundred times slower than light in free space,” he says. This effect dovetailed with another of graphene’s exceptional characteristics: Electrons pass through it at very high speeds, up to a million meters per second, or about 1/300 the speed of light in a vacuum. That meant that the two speeds were similar enough that significant interactions might occur between the two kinds of particles, if the material could be tuned to get the velocities to match. That combination of properties — slowing down light and allowing electrons to move very fast — is “one of the unusual properties of graphene,” says Soljačić. That suggested the possibility of using graphene to produce the opposite effect: to produce light instead of trapping it. “Our theoretical work shows that this can lead to a new way of generating light,” he says. Specifically, he explains, “This conversion is made possible because the electronic speed can approach the light speed in graphene, breaking the ‘light barrier.’” Just as breaking the sound barrier generates a shockwave of sound, he says, “In the case of graphene, this leads to the emission of a shockwave of light, trapped in two dimensions.” The phenomenon the team has harnessed is called the Čerenkov effect, first described 80 years ago by Soviet physicist Pavel Čerenkov. Usually associated with astronomical phenomenon and harnessed as a way of detecting ultrafast cosmic particles as they hurtle through the universe, and also to detect particles resulting from high-energy collisions in particle accelerators, the effect had not been considered relevant to Earthbound technology because it only works when objects are moving close to the speed of light. But the slowing of light inside a graphene sheet provided the opportunity to harness this effect in a practical form, the researchers say. There are many different ways of converting electricity into light — from the heated tungsten filaments that Thomas Edison perfected more than a century ago, to fluorescent tubes, to the light-emitting diodes (LEDs) that power many display screens and are gaining favor for household lighting. But this new plasmon-based approach might eventually be part of more efficient, more compact, faster, and more tunable alternatives for certain applications, the researchers say. Perhaps most significantly, this is a way of efficiently and controllably generating plasmons on a scale that is compatible with current microchip technology. Such graphene-based systems could potentially be key on-chip components for the creation of new, light-based circuits, which are considered a major new direction in the evolution of computing technology toward ever-smaller and more efficient devices. “If you want to do all sorts of signal processing problems on a chip, you want to have a very fast signal, and also to be able to work on very small scales,” Kaminer says. Computer chips have already reduced the scale of electronics to the points that the technology is bumping into some fundamental physical limits, so “you need to go into a different regime of electromagnetism,” he says. Using light instead of flowing electrons as the basis for moving and storing data has the potential to push the operating speeds “six orders of magnitude higher than what is used in electronics,” Kaminer says — in other words, in principle up to a million times faster. One problem faced by researchers trying to develop optically based chips, he says, is that while electricity can be easily confined within wires, light tends to spread out. Inside a layer of graphene, however, under the right conditions, the beams are very well confined. “There’s a lot of excitement about graphene,” says Soljačić, “because it could be easily integrated with other electronics” enabling its potential use as an on-chip light source. So far, the work is theoretical, he says, so the next step will be to create working versions of the system to prove the concept. “I have confidence that it should be doable within one to two years,” he says. The next step would then be to optimize the system for the greatest efficiency. This finding “is a truly innovative concept that has the potential to be the key toward solving the long-standing problem of achieving highly efficient and ultrafast electrical-to-optical signal conversion at the nanoscale,” says Jorge Bravo-Abad, an assistant professor at the Autonomous University of Madrid, in Spain, who was not involved in this work. In addition, Bravo-Abad says, “the novel instance of Čerenkov emission discovered by the authors of this work opens up whole new prospects for the study of the Čerenkov effect in nanoscale systems, without the need of sophisticated experimental set-ups. I look forward to seeing the significant impact and implications that these findings will surely have at the interface between physics and nanotechnology.” The research was supported by the U.S. Army Research Laboratory and the U.S. Army Research Office, through the Institute for Soldier Nanotechnologies at MIT. The team included researchers Yichen Shen, Ognjen Ilic, and Josue Lopez at MIT; Yaniv Katan at Technion, in Haifa, Israel; Hrvoje Buljan at the University of Zagreb in Croatia; and Liang Jie Wong at the Singapore Institute of Manufacturing Technology.

The International Association of HealthCare Professionals is pleased to welcome Muhamed Durakovic, MD, to their prestigious organization with his upcoming publication in The Leading Physicians of the World. He is a highly trained and qualified Family Medicine Practitioner with an extensive expertise in all facets of his work. Dr. Muhamed Durakovic has been in practice for more than 37 years and is currently serving patients within RC Hospital & Clinics in Olivia, Minnesota. Dr. Muhamed Durakovic’s career in medicine began in 1979 when he graduated with his Medical Degree from the University of Sarajevo School of Medicine, where he also obtained his Master Degree in Public Health. After his residency in Obstetrics and Gynecology at the University of Zagreb, Dr. Durakovic moved to the United States and completed a further residency in Family Medicine in Sioux Falls, South Dakota. Furthermore, Dr. Durakovic is certified by the American Board of Family Medicine. To keep up to date with the latest advances in his field, Dr. Durakovic maintains a professional membership with the American Academy of Family Physicians, and of the Bosnia-American Society. For his excellence he was honored with the prestigious Hasan Brkic Award, and was in the Top 10 Medical Students at Sarajevo Medical School. Dr. Durakovic attributes his success to his excellent education. When he is not assisting patients, Dr. Durakovic enjoys landscaping, as well as spending time with his family and grandson. Learn more about Dr. Durakovic here: and by reading his upcoming publication in The Leading Physicians of the World. is a hub for all things medicine, featuring detailed descriptions of medical professionals across all areas of expertise, and information on thousands of healthcare topics.  Each month, millions of patients use FindaTopDoc to find a doctor nearby and instantly book an appointment online or create a review. features each doctor’s full professional biography highlighting their achievements, experience, patient reviews and areas of expertise.  A leading provider of valuable health information that helps empower patient and doctor alike, FindaTopDoc enables readers to live a happier and healthier life.  For more information about FindaTopDoc, visit

Cosyns B.,Universtair Ziekenhuis Brussel | Garbi M.,King's College | Separovic J.,University of Zagreb | Pasquet A.,Catholic University of Leuven | Lancellotti P.,University of Liège
European Heart Journal Cardiovascular Imaging | Year: 2013

The update of the Echocardiography Core Syllabus of European Association of Cardiovascular Imaging (EACVI) is now available online. The Echocardiography Core Syllabus enumerates the elements of knowledge to be taught, represents a framework for the development of local training curricula and provides expected learning outcomes to the echocardiography learner. © 2013 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2013.

Hrenovic J.,University of Zagreb | Milenkovic J.,University of Belgrade | Ivankovic T.,University of Zagreb | Rajic N.,University of Belgrade
Journal of Hazardous Materials | Year: 2012

The antibacterial activity of natural zeolitized tuffs containing 2.60wt.% Cu 2+, 1.47 Zn 2+ or 0.52 Ni 2+ were tested. Antibacterial activities of the zeolites against Escherichia coli and Staphylococcus aureus were tested after 1h and 24h of exposure to 1g of the zeolite in 100mL of three different media, namely Luria Bertani, synthetic wastewater and secondary effluent wastewater. The antibacterial activities of the zeolites in Luria Bertani medium were significantly lower than those in the other media and negatively correlated with the chemical oxygen demand of the media. The Ni-loaded zeolite showed high leaching of Ni 2+ (3.44-9.13wt.% of the Ni 2+ loaded) and weak antibacterial activity in the effluent water. Since Cu-loaded zeolite did not leach Cu 2+ and the leaching of Zn 2+ from Zn-loaded zeolite was low (1.07-1.61wt.% of the Zn 2+ loaded), the strong antibacterial activity classified the Cu- and Zn-loaded zeolite as promising antibacterial materials for disinfection of secondary effluent water. © 2011 Elsevier B.V..

Sambunjak D.,Croatian Medical Journal | Sambunjak D.,University of Zagreb | Straus S.E.,University of Toronto | Marusic A.,Croatian Medical Journal | Marusic A.,University of Split
Journal of General Internal Medicine | Year: 2010

Background: Mentorship is perceived to play a significant role in the career development and productivity of academic clinicians, but little is known about the characteristics of mentorship. This knowledge would be useful for those developing mentorship programs. Objective: To complete a systematic review of the qualitative literature to explore and summarize the development, perceptions and experiences of the mentoring relationship in academic medicine. Date sources: Medline, PsycINFO, ERIC, Scopus and Current Contents databases from the earliest available date to December 2008. REVIEW Methods: We included studies that used qualitative research methodology to explore the meaning and characteristics of mentoring in academic medicine. Two investigators independently assessed articles for relevance and study quality, and extracted data using standardized forms. No restrictions were placed on the language of articles. RESULTS: A total of 8,487 citations were identified, 114 full text articles were assessed, and 9 articles were selected for review. All studies were conducted in North America, and most focused on the initiation and cultivation phases of the mentoring relationship. Mentoring was described as a complex relationship based on mutual interests, both professional and personal. Mentees should take an active role in the formation and development of mentoring relationships. Good mentors should be sincere in their dealings with mentees, be able to listen actively and understand mentees' needs, and have a well-established position within the academic community. Some of the mentoring functions aim at the mentees' academic growth and others at personal growth. Barriers to mentoring and dysfunctional mentoring can be related to personal factors, relational difficulties and structural/institutional barriers. Conclusions: Successful mentoring requires commitment and interpersonal skills of the mentor and mentee, but also a facilitating environment at academic medicine's institutions. © 2009 Society of General Internal Medicine.

Stulhofer A.,University of Zagreb | Traeen B.,University of Tromsø | Carvalheira A.,University of Lisbon
Journal of Sexual Medicine | Year: 2013

Introduction. Epidemiological evidence for the association between job-related stress and sexual difficulties in men is largely lacking. Little is known about the factors that may mediate or moderate this relationship. Aim. This study analyzes the association between job-related difficulties and men's sexual difficulties. Main Outcome Measures. Job-related difficulties were measured by 10 yes/no questions that addressed a range of adverse workplace situations. The experience of sexual difficulties in the past 12 months was assessed by using seven dichotomous indicators developed in the National Study of Sexual Attitudes and Lifestyles (NATSAL) 2000. Method. Analyses were carried out using data from a 2011 online study of Portuguese, Croatian, and Norwegian men (N=2,112). Multivariate logistic regression and mediation analysis were used to test the hypothesized association. Results. Men with job-related concerns reported lower sexual satisfaction than men without such concerns did (F=7.53, P<0.001). Multivariate analysis confirmed the association between job-related and sexual health concerns. The odds of experiencing one or more sexual health difficulties in the past 12 months were about 1.8 times higher among men who reported the highest levels of workplace difficulties than among men who experienced no such difficulties. The odds of reporting sexual health difficulties were significantly reduced by a higher income (adjusted odds ratio [AOR]=0.87, P<0.01), emotional intimacy with one's partner (AOR=0.93, P<0.001), having children (AOR=0.62-0.66, P<0.01), and country-specific effects (AOR=1.98-2.22, P<0.001). In all three countries, the relationship between job-related and sexual health difficulties was mediated by anxiety and depression. Conclusions. The findings suggest that negative mood is the mechanism behind the association between workplace strain and sexual difficulties. Emotional support, such as couple intimacy and fatherhood, can reduce-independently from sociocultural and socioeconomic factors-the risk of sexual health concerns. © 2012 International Society for Sexual Medicine.

Krajacic G.,University of Zagreb | Duic N.,University of Zagreb | Duic N.,University of Lisbon | Carvalho M.D.G.,University of Lisbon
Applied Energy | Year: 2011

Portugal is a country with an energy system highly dependent on oil and gas imports. Imports of oil and gas accounted for 85% of the country's requirements in 2005 and 86% in 2006. Meanwhile, the share of renewable energy sources (RES) in the total primary energy consumption was only 14% in 2006. When focusing only on electricity production, the situation is somewhat better. The share of RES in gross electricity production varies between 20% and 35% and is dependent on the hydropower production in wet and dry years. This paper presents, on a national scale, Portugal's energy system planning and technical solutions for achieving 100% RES electricity production. Planning was based on hourly energy balance and use of H2RES software. The H2RES model provides the ability to integrate various types of storages into energy systems in order to increase penetration of the intermittent renewable energy sources or to achieve a 100% renewable island, region or country. The paper also represents a stepping-stone for studies offering wider possibilities in matching and satisfying electricity supply in Portugal with potential renewable energy sources. Special attention has been given to intermittent sources such as wind, solar and ocean waves that can be coupled to appropriate energy storage systems charged with surplus amounts of produced electricity. The storage systems also decrease installed power requirements for generating units. Consequently, these storages will assist in avoiding unnecessary rejection of renewable potential and reaching a sufficient security of energy supply. © 2010 Elsevier Ltd.

Segurado R.,University of Lisbon | Krajacic G.,University of Zagreb | Duic N.,University of Lisbon | Duic N.,University of Zagreb | Alves L.,University of Lisbon
Applied Energy | Year: 2011

In this article different scenarios are analysed with the objective of increasing the penetration of renewable energies in the energy system of S. Vicente Island in Cape Verde. An integrated approach is used to analyse the electricity and water supply systems. The H2RES model, a tool designed to simulate the integration of renewable sources and hydrogen in the energy systems of islands or other isolated locations, is applied. There is no other source of fresh water available to supply the population of S. Vicente, apart from desalinated seawater. The electricity supply system of this Island is based on fossil fuel and wind. S. Vicente has important wind resources that are not fully used because of its intermittent nature. The topography of this Island is relatively uniform, with the exception of Mont Verde, a 774 m high mountain located in its centre, which could be suitable for pumped hydro storage. The present analysis incorporates the possibility of using pumped hydro as a storage technique to increase the penetration of renewable energy sources, using desalinated seawater. The results show that is possible to have more than 30% of yearly penetration of renewable energy sources in the electricity supply system, together with more than 50% of the water supplied to the population produced from wind electricity. © 2010 Elsevier Ltd.

Orlic N.,RIZ Transmitters Co. | Loncaric S.,University of Zagreb
Computers and Geosciences | Year: 2010

An important and challenging problem in seismic data processing is to discriminate between natural seismic events such as earthquakes and artificial seismic events such as explosions. Many automatic techniques for seismogram classification have been proposed in the literature. Most of these methods have a similar approach to seismogram classification: a predefined set of features based on ad-hoc feature selection criteria is extracted from the seismogram waveform or spectral data and these features are used for signal classification. In this paper we propose a novel approach for seismogram classification. A specially formulated genetic algorithm has been employed to automatically search for a near-optimal seismogram feature set, instead of using ad-hoc feature selection criteria. A boosting method is added to the genetic algorithm when searching for multiple features in order to improve classification performance. A learning set of seismogram data is used by the genetic algorithm to discover a near-optimal feature set. The feature set identified by the genetic algorithm is then used for seismogram classification. The described method is developed to classify seismograms in two groups, whereas a brief overview of method extension for multiple group classification is given. For method verification, a learning set consisting of 40 local earthquake seismograms and 40 explosion seismograms was used. The method was validated on seismogram set consisting of 60 local earthquake seismograms and 60 explosion seismograms, with correct classification of 85%. © 2009 Elsevier Ltd. All rights reserved.

Batas Bjelic I.,University of Belgrade | Rajakovic N.,University of Belgrade | Cosic B.,University of Zagreb | Duic N.,University of Zagreb
Energy | Year: 2013

Serbia has wind with a good capacity factor, the respectable potential of which has not hitherto been utilized. There are a number of proposed wind power projects with an envisaged capacity of up to 2500MW and the project documentation has been developed for 1300MW. Within the existing feed-in tariff scheme, only 500MW are eligible. This limitation is set in a conservative manner bearing in mind moderation (balancing) needs due to the variability of wind power generation. The existing Serbian energy system, with significant hydro generation, available pumped storage hydro capacity, and strong interconnections has many moderators for variable wind generation and for reliable technical performance of the grid. In this study, energy imbalances under different levels of wind penetration into the Serbian energy system were analyzed. Possible new moderation strategies for lowering energy imbalances due to wind integration were evaluated using the EnergyPLAN tool and are presented in this paper. © 2013 Elsevier Ltd.

Filardo G.,Rizzoli Orthopaedic Institute | Madry H.,Saarland University | Jelic M.,University of Zagreb | Roffi A.,Rizzoli Orthopaedic Institute | And 2 more authors.
Knee Surgery, Sports Traumatology, Arthroscopy | Year: 2013

Purpose: The aim of this systematic review is to examine the available clinical evidence in the literature to support mesenchymal stem cell (MSC) treatment strategies in orthopaedics for cartilage defect regeneration. Methods: The research was performed on the PubMed database considering the English literature from 2002 and using the following key words: cartilage, cartilage repair, mesenchymal stem cells, MSCs, bone marrow concentrate (BMC), bone marrow-derived mesenchymal stem cells, bone marrow stromal cells, adipose-derived mesenchymal stem cells, and synovial-derived mesenchymal stem cells. Results: The systematic research showed an increasing number of published studies on this topic over time and identified 72 preclinical papers and 18 clinical trials. Among the 18 clinical trials identified focusing on cartilage regeneration, none were randomized, five were comparative, six were case series, and seven were case reports; two concerned the use of adipose-derived MSCs, five the use of BMC, and 11 the use of bone marrow-derived MSCs, with preliminary interesting findings ranging from focal chondral defects to articular osteoarthritis degeneration. Conclusions: Despite the growing interest in this biological approach for cartilage regeneration, knowledge on this topic is still preliminary, as shown by the prevalence of preclinical studies and the presence of low-quality clinical studies. Many aspects have to be optimized, and randomized controlled trials are needed to support the potential of this biological treatment for cartilage repair and to evaluate advantages and disadvantages with respect to the available treatments. Level of evidence: IV. © 2013 Springer-Verlag Berlin Heidelberg.

Henigsberg N.,University of Zagreb | Mahableshwarkar A.R.,Takeda Global Research and Development Center | Jacobsen P.,Takeda Global Research and Development Center | Chen Y.,Takeda Global Research and Development Center | Thase M.E.,University of Pennsylvania
Journal of Clinical Psychiatry | Year: 2012

Objective: Lu AA21004 is an investigational multimodal antidepressant. This randomized controlled trial evaluated the efficacy and tolerability of multiple doses of Lu AA21004 versus placebo in adults with major depressive disorder (MDD). Method: Adults diagnosed with MDD (based on DSM-IV-TR criteria) with a Montgomery-Asberg Depression Rating Scale (MADRS) score ≥ 26 were randomly assigned (1:1:1:1) to receive Lu AA21004 1 mg, 5 mg, or 10 mg or placebo for 8 weeks (between August 2008 and August 2009). The primary endpoint was reduction in 24-Item Hamilton Depression Rating Scale (HDRS-24) total score after 8 weeks of treatment compared with placebo for Lu AA21004 10 mg. Additional outcomes included response and remission rates, Sheehan Disability Scale (SDS), Clinical Global Impressions-Global Improvement scale (CGI-I), MADRS total score, and HDRS-24 total score in subjects with baseline Hamilton Anxiety Rating Scale (HARS) score ≥ 20. Adverse events were assessed throughout the study. Results: A total of 560 subjects (mean age = 46.4 years) were randomized. There was a statistically significant reduction from baseline in HDRS-24 total score at week 8 for Lu AA21004 10 mg vs placebo (P < .001). There were improvements (nominal P values < .05 with no adjustment for multiplicity) in HDRS-24 total score, response and remission rates, CGI-I score, MADRS total score, and HDRS-24 total score in subjects with baseline HARS score ≥ 20 at week 8 for all Lu AA21004 treatment groups vs placebo. No significant differences were seen in SDS scores between any dose of Lu AA21004 and placebo. The most common adverse events were nausea, headache, and dizziness. Conclusions: After 8 weeks of treatment with Lu AA21004 10 mg, there was a significant reduction in HDRS-24 total score compared with placebo in adults with MDD. Lu AA21004 was well tolerated in this study. Trial Registration: identifier: NCT00735709. © Copyright 2012 Physicians Postgraduate Press, Inc.

Mannini C.,University of Florence | Soda A.,University of Zagreb | Schewe G.,German Aerospace Center
Computers and Fluids | Year: 2010

The unsteady flow field around a two-dimensional rectangular prism with a fineness ratio (chord-to-thickness) of 5.0, is studied using Unsteady Reynolds-Averaged Navier-Stokes (URANS) equations. A noncommercial unstructured flow solver is used in the simulations at various Reynolds numbers (from 26,000 to 1,850,000 based on the chord length), two different angles of attack (0° and 4°) and low Mach number (0.1). A grid-convergence study is presented in order to investigate the dependence of the flow solution on the spatial and temporal discretization. Results obtained with one- and two-equation turbulence models are compared, including models based on the Explicit Algebraic Reynolds Stress (EARSM) approach. The aim of this work is to assess the capability of the computationally efficient two-dimensional URANS calculations to predict the features of complex massively separated flow around this type of geometry. A further goal is to use numerical simulations to investigate the strong Reynolds number effects observed in wind-tunnel experiments. Satisfactory agreement with the wind-tunnel data is obtained for several test cases, but only the turbulence model based on the EARSM approach captured the significant lift increase at non-zero angles of attack due to variation of Reynolds number. This phenomenon is shown to be related to the progressive upstream migration of the time-averaged shear-layer reattachment location on one side of the rectangular cylinder. The effects of the Reynolds number on the mechanism of vortex shedding are also explored in the simulations. © 2010 Elsevier Ltd.

Friscic T.,McGill University | Friscic T.,University of Cambridge | Halasz I.,University of Zagreb | Halasz I.,Max Planck Institute for Solid State Research | And 6 more authors.
Nature Chemistry | Year: 2013

Chemical and structural transformations have long been carried out by milling. Such mechanochemical steps are now ubiquitous in a number of industries (such as the pharmaceutical, chemical and metallurgical industries), and are emerging as excellent environmentally friendly alternatives to solution-based syntheses. However, mechanochemical transformations are typically difficult to monitor in real time, which leaves a large gap in the mechanistic understanding required for their development. We now report the real-time study of mechanochemical transformations in a ball mill by means of in situ diffraction of high-energy synchrotron X-rays. Focusing on the mechanosynthesis of metal-organic frameworks, we have directly monitored reaction profiles, the formation of intermediates, and interconversions of framework topologies. Our results reveal that mechanochemistry is highly dynamic, with reaction rates comparable to or greater than those in solution. The technique also enabled us to probe directly how catalytic additives recently introduced in the mechanosynthesis of metal-organic frameworks, such as organic liquids or ionic species, change the reactivity pathways and kinetics. © 2013 Macmillan Publishers Limited. All rights reserved.

Velcic I.,Basque Center for Applied Mathematics | Velcic I.,University of Zagreb
Journal of Elasticity | Year: 2012

We present a nonlinear model of weakly curved rod, namely the type of curved rod where the curvature is of the order of the diameter of the cross-section. We use an approach analogous to the one for rods and curved rods and start from the strain energy functional of three dimensional nonlinear elasticity. We do not impose any constitutional behavior of the material and work in a general framework. To derive the model, by means of Γ-convergence, we need to set the order of strain energy (i.e., its relation to the thickness of the body h). We analyze the situation when the strain energy (divided by the order of volume) is of the order h 4. This is the same approach as the one used in Föppl-von Kármán model for plates and the analogous model for rods. The obtained model is analogous to Marguerre-von Kármán for shallow shells and its linearization is the linear shallow arch model which can be found in the literature. © Springer Science+Business Media B.V. 2011.

Dzolic Z.,Ruder Boskovic Institute | Cametti M.,Polytechnic of Milan | Milic D.,University of Zagreb | Milic D.,Paul Scherrer Institute | Zinic M.,Ruder Boskovic Institute
Chemistry - A European Journal | Year: 2013

Isomeric pyridyloxalamide derivatives 1-3, which differed in the position of the nitrogen atom on the pyridyl ring, showed remarkably different gel-forming aptitudes in the presence of CuCl2 salt in alcohols. Whilst derivatives 1 and 3 formed a soluble complex and a solid precipitate, respectively, ligand 2 generated a remarkably metal- and anion-specific metallogel. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Vukovic J.,University of Zagreb | Avidad M.A.,University of Granada | Capitan-Vallvey L.F.,University of Granada
Talanta | Year: 2012

This paper presents the development, characterization and quality control of analytical methods based on the use of disposable optical sensors for determination of heavy metals. Chromogenic reagents such as 1-(2-pyridylazo)-2- naphthol, (2-pyridylazo)resorcinol, Zincon, Ferrozine, and Chromazurol S were used to develop optical sensors of heavy metal ions found as contaminants in pharmaceutical substances and products, such as Zn(II), Cu(II), Ni(II), Fe(II), and Fe(III). The chromogenic reagents were immobilized in polymeric membranes by spin-coating from cocktails containing all reagents needed. The methods were prevalidated using a comprehensive quality control strategy based on a system of mathematical/statistical testing and diagnosis of each prevalidation step. This system involved characterization of analytical groups; checking of two limiting groups; testing of data homogeneity; recognition of outliers; and determination of analytical functions, limiting values, precision and accuracy. The prevalidation strategy demonstrated the reliability of the proposed method and pointed out some limitations. Combining the optical sensors with multicomponent linear regression allowed simultaneous determination of multiple metals in synthetic mixtures with different compositions. Good agreement between experimental and theoretical amounts of heavy metals in the mixtures was obtained for the majority of sensors and metals. Even better agreement was obtained between the experimental and theoretical total amounts of metals in the mixtures. The proposed analytical methods were successfully applied to the determination of zinc in pharmaceutical preparations of insulin and the determination of metal mixtures in a commercial nasal spray of isotonic seawater. The reliable and sensitive individual optical sensors developed in this study may be useful for designing a multimembrane optical tongue that with appropriate further optimization can be used for screening heavy metals in various matrices. © 2012 Elsevier B.V. All rights reserved.

Milovic M.,Medical and Chemical School | Mitic B.,University of Zagreb
Natura Croatica | Year: 2012

Zadar, one of the oldest towns in Croatia, is situated in North Dalmatia. A floristic survey performed between 2005 and 2008 included vascular native and non-native taxa with the ability to survive outside crops. A total of 926 vascular plant species and subspecies, from 470 genera and 107 families were recorded. The most common families are Asteraceae s.l. (12.42%), Poaceae (11.02%) and Fabaceae (9.83%), while therophytes (42.98%) are the most abundant life form. The predominant presentation of therophytes with respect to other life forms has been recognized as a feature common to both the Mediterranean climate and urban areas. The prevailing representation of Mediterranean plants in the flora of the city of Zadar (32.83%) demonstrates that this flora is, despite the exposure to durable anthropogenic influence, still developing under the prevailing influence of the Mediterranean climate conditions. A significant number of cultivated and adventitious taxa (19.22%) and widespread taxa (15.55%) in the flora of the city of Zadar is an indicator of human impact. Although the flora of the city of Zadar is an urban flora it comprises of 17 endemic, 27 threatened and 176 protected taxa.

Belusic D.,Monash University | Hrastinski M.,Croatian Meteorological and Hydrological Service | Vezcenaj Z.,University of Zagreb | Grisogono B.,University of Zagreb
Journal of Applied Meteorology and Climatology | Year: 2013

Winds through the Vratnik Pass, a mountain gap in the Dinaric Alps, Croatia, are polarized along the gap axis that extends in the northeast-southwest direction. Although stronger northeasterly wind at the Vratnik Pass is frequently related to the Adriatic bora wind, especially at the downstream town of Senj, there are many cases in which the wind at Senj is directionally decoupled from the wind at the Vratnik Pass. Acluster analysis reveals that this decoupling is sometimes related to lower wind speeds or a shallow southeasterly sirocco wind along the Adriatic, but in many cases the bora blows over a wider region, while only Senj has a different wind direction. Several mechanisms can be responsible for the latter phenomenon, including the formation of a lee wave rotor. A numerical model simulation corroborates the decoupling caused by a rotor for a single case. The prevalence of northeasterly winds at the Vratnik Pass during southeasterly sirocco episodes is another result that challenges the current understanding. It is shown that, at least in one of these episodes, this phenomenon is related to a secondary mesoscale low pressure center in the eastern lee of the Apennines that forms as a subsystem of a broader Genoa cyclone. Less frequent southwesterly winds through the gap are predominantly related to the thermal sea breeze and anabatic circulations that are sometimes superimposed on the geostrophic wind. © 2013 American Meteorological Society.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: YOUNG-3-2015 | Award Amount: 2.50M | Year: 2016

Most European Lifelong Learning (LLL) policies have been designed to create economic growth and, at the same time, guarantee social inclusion (EC 2010). First, we will study how different LLL policies are compatible with each other in terms of their orientations and objectives and how each policy considers the needs of young adults. Second, we will research the intended and unintended effects of policies on young adults. In this regard, we will look into relevant social developments such as life course de-standardisation processes and into an emerging new political economy of skills. Third, we will generate new knowledge about regional and local policymaking, with particular attention to actors, dynamics, and trends. By focusing on their regional/local context, we will elucidate the interaction and complementarity of LLL policies with other sectors of society, thus contributing to a better understanding of current fragmentation and discrepancies, in order to set parameters for future decision-making support systems. The project will first contribute new knowledge of the impact of LLL policies on young adults life courses, yielding insights on the conditions, strategies, and necessities for policies to become effective. In addition, it will provide insights on the innovations and potentials they unlock, in particular with view to informal and non-formal learning to better address vulnerable groups. Second, the project contributes to a better understanding of the structural relationships and functional match between education/training and the labour market sectors. Third, the project will provide a thorough review of regional policies and initiatives in the countries studied, laying bare distinct dynamics and trends, but also mismatches and redundancies. In particular, the project aims at identifying successful programmes in terms of sustainable solutions in integrating labour market with, social inclusion as well as their transferability to other contexts.

Agency: Cordis | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2015 | Award Amount: 1.38M | Year: 2015

The development and adoption of renewable and sustainable forms of energy has become a major priority for Europe and is an important theme in H2020. Research into new, energy-related technologies to reduce Europes reliance on non-renewable fossil fuels is a critical need, and requires more newly qualified people in areas such as renewable-energy infrastructure management, new energy materials and methods, as well as smart buildings and transport. Bio-energy is particularly relevant to the Work Programme, because it is at the crossroads of several key European policies from the Strategic Energy Technology Plan Roadmap on Education and Training (SET-Plan) to the European Bio-economy Strategy for European Food Safety and Nutrition Policy. So far, technological development has concentrated on using crops and wood for fuel, energy and industrial products. These conventional bio-resources are, however, limited, and the use of nonconventional, currently unused or under-utilised bio-resources provides the best possibility for the growth of the bioeconomy. However, European development in this priority field is failing to keep pace with demand due to a lack of qualified personnel, a lack of cohesion and integration among stakeholders, and poorly developed links between professional training and the real needs of industry. Based on seven work packages the Phoenix RISE project will address these issues by exploiting the complementary expertise of its partners and creating synergies between them through the targeted secondments of staff to advance research and innovation knowledge in bio-energy research. Phoenix is an international, interdisciplinary, cross-sectorial project, bringing together a total of 16 partners: 14 from the EU (5 companies and 9 academic organisations) and two Third-Country academic partners to enhance its collective research excellence and create new, post-graduate-level research training in key disciplines that support the provision of bio-energy.

Agency: Cordis | Branch: H2020 | Program: CSA | Phase: LCE-04-2015 | Award Amount: 1.64M | Year: 2016

The objective of CoolHeating is to support the implementation of small modular renewable heating and cooling grids for communities in South-Eastern Europe. This will be achieved through knowledge transfer and mutual activities of partners in countries where renewable district heating and cooling examples exist (Austria, Denmark, Germany) and in countries which have less development (Croatia, Slovenia, Macedonia, Serbia, Bosnia-Herzigowina). Core activities, besides techno-economical assessments, include measures to stimulate the interest of communities and citizens to set-up renewable district heating systems as well as the capacity building about financing and business models. The outcome will be the initiation of new small renewable district heating and cooling grids in 5 target communities up to the investment stage. These lighthouse projects will have a long-term impact on the development of small modular renewable heating and cooling grids at the national levels in the target countries.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.9.10 | Award Amount: 7.65M | Year: 2013

The aim of ASSISI_bf is to develop (1) a fundamental new class of distributed ICT systems, which are bio-hybrid collective adaptive systems (CASs) that consist of two sub-systems: One is a self-organising society of animals; the other one is a society of technical devices. These CASs will solve problems by distributed spatial computation; this heterogeneous system (animals, robots, nodes) will perform collective decision-making and maintain internal homeostasis. (2) We plan to develop a fundamental new method to design CASs by exploiting evolutionary computation on mathematical models that are used to drive the engineered part of the CAS. This way the collective of animals and robots will adapt to environmental changes and will maximize its efficiency and stability. (3) We will develop several novel benchmarks, using the level of acceptance of robots by the animal society as a hard-to-reach criterion. (4) Finally, we will derive a general model for heterogeneous CASs, which will be used to develop new algorithms for other heterogeneous robotic CASs. We address all 3 principles that should be researched for CASs, which are: design, operation and evolution. The project tackles several severe engineering challenges. It has a high potential of impact and foundational character on several communities. On the one hand it has the potential to establish a new field of science, which focuses on self-adapting engineered systems able to integrate themselves into an existing natural society. On the other hand, the proposed long-term impact reaches from establishing important new methods in agriculture, environmental sustainability policies, live stock management, environmental monitoring, bio-hybrid engineering and pharmaceutical industry, as our proposed technology allows fully automated (but non-invasive, non-harmful) experimentation with social animals. By deducting models and algorithms our project can also influence and promote general research of distributed ICT systems.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-24-2015 | Award Amount: 4.62M | Year: 2016

The European market for e-commerce is growing rapidly, with more than 16% just in the year 2014. With the internationalization of distribution chains, the key for success lies within efficient logistics. In such facilities, goods for the end-user or products in the B2B sector are stored, commissioned and shipped. To manage the supply chains, many new warehouses have been erected and more will follow. With the growing markets, the need for larger warehouses and their automation increases. To advance the position of the European trade sector, technical restrictions on the size of warehouses should be avoided and new automation paradigm should be implemented to ensure their efficient operation. Therefore the European robotic and automation companies should be able to provide appropriate solutions, making scalable systems and scalable software mandatory. Current automation solutions based on strict separation of humans and robots cannot provide such efficient operation of large warehouses. SafeLog aims to overcome this issue by enabling much more efficient warehouse concepts joining human and robot workforce. Given that, the overall objective of SafeLog is the conception and implementation of a large-scale flexible warehouse system which enables safe and efficient collaboration of humans and robots in the same area and at the same time. On the way to reach this objective SaveLog will develop, integrate and test: (1) a holistic and certifiable safety concept based on the safety vest, which allows the collaboration of robots and humans in a flexible warehouse system, (2) planning and scheduling algorithms for a heterogeneous fleet manager, which allow the adhoc reactive planning and scheduling for human and robot workforce in a flexible warehouse system, and (3) augmented reality based interaction strategies to support workers in a robotized warehouse system with information about their current task and environment.

Agency: Cordis | Branch: H2020 | Program: CSA | Phase: SC5-13c-2015 | Award Amount: 2.00M | Year: 2016

MIN-GUIDE is a project addressing the need for a secure and sustainable supply of minerals in Europe by developing a Minerals Policy Guide. The key objectives of the project are (1) providing guidance for EU and MS minerals policy, (2) facilitating minerals policy decision making through knowledge co-production for transferability of best practice minerals policy, and (3) fostering community and network building for the co-management of an innovation catalysing minerals policy framework. This will be achieved through a systematic profiling and policy benchmarking of relevant policy and legislation in Europe, which includes the identification of innovation friendly best practices through quantitative indicators and a qualitative analysis country-specific framework conditions, as well as through the compilation of minerals statistics and reporting systems. These insights will form the basis for developing an interactive, tailor-made online Minerals Policy Guide. Another key feature of the MIN-GUIDE project will be knowledge co-production for minerals policy decision makers through Policy Laboratories exploring these best practice examples along the whole mineral production value chain (exploration and extraction, processing, recycling and mine closure). Furthermore, MIN-GUIDE will facilitate the building of a sustainable minerals policy stakeholder network through this knowledge co-production and utilization in Policy Laboratories as well as through three major Conferences. These Conferences will explore the minerals governance framework, work on recommendations for promoting innovation along the whole minerals production value chain, and put it into the wider context of the circular economy. The MIN-GUIDE project and in particular the dissemination of the Minerals Policy Guide to specific target audiences will have the expected impact of guiding EU MS and EU level minerals policy-making towards a more coherent, transparent and innovation-catalysing framework.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETHPC-1-2014 | Award Amount: 5.80M | Year: 2015

MANGO targets to achieve extreme resource efficiency in future QoS-sensitive HPC through ambitious cross-boundary architecture exploration for performance/power/predictability (PPP) based on the definition of new-generation high-performance, power-efficient, heterogeneous architectures with native mechanisms for isolation and quality-of-service, and an innovative two-phase passive cooling system. Its disruptive approach will involve many interrelated mechanisms at various architectural levels, including heterogeneous computing cores, memory architectures, interconnects, run-time resource management, power monitoring and cooling, to the programming models. The system architecture will be inherently heterogeneous as an enabler for efficiency and application-based customization, where general-purpose compute nodes (GN) are intertwined with heterogeneous acceleration nodes (HN), linked by an across-boundary homogeneous interconnect. It will provide guarantees for predictability, bandwidth and latency for the whole HN node infrastructure, allowing dynamic adaptation to applications. MANGO will develop a toolset for PPP and explore holistic pro-active thermal and power management for energy optimization including chip, board and rack cooling levels, creating a hitherto inexistent link between HW and SW effects at all layers. Project will build an effective large-scale emulation platform. The architecture will be validated through noticeable examples of application with QoS and high-performance requirements. Ultimately, the combined interplay of the multi-level innovative solutions brought by MANGO will result in a new positioning in the PPP space, ensuring sustainable performance as high as 100 PFLOPS for the realistic levels of power consumption (<15MWatt) delivered to QoS-sensitive applications in large-scale capacity computing scenarios providing essential building blocks at the architectural level enabling the full realization of the ETP4HPC strategic research agenda.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-3.1-1;HEALTH-2007-3.3-1 | Award Amount: 2.88M | Year: 2009

BECAN is an epidemiological study aiming at mapping child abuse and neglect (CAN) in the general population of 11 to 16-year-old children that attend and those that have dropped-out school and at identifying the number of reported/detected cases of CAN being recorded in at least 8 Balkan countries. Mapping of CAN will be achieved by applying two of the I-CAST questionnaires (ICAST-CH for children and ICAST_P for parents, created by ISPCAN with the support of UNICEF) to matched pairs of children and parents. I-CAST questionnaires will first be translated into the official languages of the participating countries and culturally validated. There is no information on the prevalence of CAN in the general population of children in Balkan countries, and this study is certainly the larger in sample size ever conducted in the Balkan area (over 30.000 children and parents), and probably one of the biggest globally. CAN is associated with unhealthy behaviour in children and adolescents. Particularly, due to the well established circle of violence phenomenon, domestic violence tends to reproduce itself. Preventive cutting off of that circle contributes substantially and more effectively in the disappearance of such unhealthy behaviour in both children and adults. It is also believed that this study will provide the basis for the harmonization of CAN screening procedures in the Balkan area, and offer valuable tools to relevant policy-making activities in all participating Balkan countries.

Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2010-ITN | Award Amount: 3.92M | Year: 2011

TRANSMIT will provide a coordinated programme of academic and industrial training in an area of immediate interest to the European society. It focuses on atmospheric phenomena that can significantly impair a wide range of systems and applications that are at the core of several activities embedded in our daily life. TRANSMIT deals with the harmful effects of the ionosphere on these systems, which will become increasingly significant as we approach the next solar maximum, predicted for 2013. It will gather major European stakeholders in a large multi-site ITN to develop real time integrated state of the art tools to mitigate ionospheric threats to Global Navigation Satellite Systems (GNSS) and several related applications, such as civil aviation, marine navigation and land transportation. TRANSMIT will expand the European knowledge base and ensure its sustainability by preparing young researchers in a multidisciplinary, intersectorial, industry-led training programme. Its driving forces are the EC prediction of an annual global market for GNSS of 300bn by 2020 and the fact that Europes own GNSS, Galileo, will be fully operational by 2013, just when the impact of the ionosphere will be greatest. GNSS satellite signals and any others operating below 10 GHz, including communications (satellite and HF), remote sensing and Earth observation systems, are extremely vulnerable to ionospheric phenomena. This formidable fast growing community lacks robust counter-measures to deal with these threats. Advancement in this area has been limited by: A shortage of human resources in relevant Engineering disciplines; The lack of a multidisciplinary framework where the various specialist research groups can devise solutions of practical value to end users. TRANSMIT will overcome this by providing a concerted training programme including taught courses, research projects and secondments that will arm the researchers of tomorrow with the necessary skills and knowledge.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.1.4-1 | Award Amount: 7.38M | Year: 2012

Goals: We propose a regenerative medicine clinical trial of the therapeutic system OSTEOGROW for regenerating bone through harnessing a novel bone device to accelerate and enhance bone repair. The osteogenic device is composed of an autologous carrier and a biologically active recombinant human protein offering a therapeutic solution in bone regeneration superior to currently available options. The autologous carrier is a whole blood-derived coagulum device (WBCD) from the peripheral blood of a patient, which will act as an endogenous biocompatible material causing significantly less inflammatory reactions than currently used bone devices. The bone inducing molecule is the recombinant human bone morphogenetic protein 6 (BMP6) which binds to WBCD and is more potent than other BMPs in stimulating bone formation in preclinical animal models. The consortium members will scale-up the production of BMP6 from an already developed working cell bank to enter clinical trials on bone regeneration. The bone diseases we will treat locally with OSTEOGROW are acute radius fractures and recalcitrant non-unions of the tibia. These conditions are widespread and highly debilitating diseases for which such therapy holds great promise. Workflow: Preliminary pre-clinical data are already available, and clinical grade (GMP) BMP6 will be available before the beginning of the project to perform toxicology studies and to determine the final formulation of OSTEOGROW. Clinical trials will start within 18 months from the start of the project funding. Business strategy: SMEs Genera Research and BioTest will develop and validate the BMP6 production in their facilities. Consortium members from Medical University of Vienna, Sarajevo University Clinical Centre, Linkoping University Faculty of Health Sciences, Zagreb University Trauma Clinic, SMART Medico and Paul Regulatory Services will perform, monitor and coordinate clinical trials. OSTEOGROW will find a wide use in human and veterinary medicine.

Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2007-2.2-01 | Award Amount: 5.63M | Year: 2008

The ultimate goal of CLARIN is the construction and operation of a shared distributed infrastructure that aims at making language resources and technology available to the humanities and social sciences research communities at large. The preparatory phase will pave the way for implementation along 4 dimensions: Funding and governance: The aim is to bring together the funding agencies and to work out a ready-to-sign draft agreement between the funding agencies in the participating countries about governance, financing, construction and operation of the infrastructure. Technical: The technical objective is to provide a detailed specification of the infrastructure, agreement on data and interoperability standards to be adopted, and a running, validated prototype based on these specifications. The validation should cover technical, linguistic and user aspects. Language: For the validation the prototype will be populated with a selection of language resources and technologies for all participating languages. The objective is to deliver a sufficiently populated, and thoroughly tested prototype that demonstrates the adequacy of the approach for all participating languages. User: In order to fully exploit the potential of what language resources and technology have to offer to the humanities and social sciences communities we will: (i) make an analysis of current practice in the use of language technology in the humanities in order to establish the needs; (ii) launch and monitor typical humanities projects in order to validate the prototype and its specifications; (iii) create awareness in the humanities and social sciences communities of the potential of the use of language resources and technology to improve or innovate their research; (iv) bring together the humanities and language technology communities in order to ensure lasting synergies.

News Article | November 23, 2015

The most widely used technology for producing X-rays – used in everything from medical and dental imaging, to testing for cracks in industrial materials – has remained essentially the same for more than a century. But based on a new analysis by researchers at MIT and in Singapore, that might potentially change in the next few years. The finding, based on a new theory backed by exact simulations, shows that a sheet of graphene – a two-dimensional form of pure carbon – could be used to generate surface waves called plasmons when the sheet is struck by photons from a laser beam. These plasmons in turn could be triggered to generate a sharp pulse of radiation, tuned to wavelengths anywhere from infrared light to X-rays. What’s more, the radiation produced by the system would be of a uniform wavelength and tightly aligned, similar to that from a laser beam. The team says this could potentially enable lower-dose X-ray systems in the future, making them safer. The new work is reported this week in the journal Nature Photonics, in a paper by MIT professors Marin Soljačić and John Joannopoulos and postdocs Ido Kaminer and Ognjen Ilic, and Liang Jie Wong at the Singapore Institute of Manufacturing Technology. Soljačić says that there is growing interest in finding new ways of generating sources of light, especially at scales that could be incorporated into microchips or that could reduce the size and cost of the high-intensity beams used for basic scientific and biomedical research. Of all the wavelengths of electromagnetic radiation commonly used for applications, he says, “coherent X-rays are particularly hard to create.” They also have the highest energy. The new system could, in principle, create ultraviolet light sources on a chip and table-top X-ray devices that could produce the sorts of beams that now require huge, multimillion-dollar particle accelerators. To make focused, high-power X-ray beams, “the usual approach is to create high-energy charged particles [using an accelerator] and ‘wiggle’ them,” says Kaminer. “The oscillations will produce X-rays. But that approach is very expensive,” and the few facilities available nationwide that can produce such beams are highly oversubscribed. “The dream of the community is to make them small and inexpensive,” he says. Most sources of X-rays rely on extremely high-energy electrons, which are hard to produce. But the new method gets around that, using the tightly-confined power of the wave-like plasmons that are produced when a specially patterned sheet of graphene gets hit by photons from a laser beam. These plasmons can then release their energy in a tight beam of X-rays when triggered by a pulse from a conventional electron gun similar to those found in electron microscopes. “The reason this is unique is that we’re substantially bypassing the problem of accelerating the electrons,” he says. “Every other approach involves accelerating the electrons. This is unique in producing X-rays from low-energy electrons.” In addition, the system would be unique in its tunability, able to deliver beams of single-wavelength light all the way from infrared, through visible light and ultraviolet, on into X-rays. And there are three different inputs that can be used to control the tuning of the output, Kaminer explains – the frequency of the laser beam to initiate the plasmons, the energy of the triggering electron beam, and the “doping” of the graphene sheet. Such beams could have applications in crystallography, the team says, which is used in many scientific fields to determine the precise atomic structure of molecules. Because of its tight, narrow beam, the system might also allow more precise pinpointing of medical and dental X-rays, thus potentially reducing the radiation dose received by a patient, they say. So far, the work is theoretical, based on precise simulations, but the group’s simulations in the past have tended to match quite well with experimental results, Soljačić says. “We have the ability in our field to model these phenomena very exactly.” They are now in the process of building a device to test the system in the lab, starting initially with producing ultraviolet sources and working up to the higher-energy X-rays. “We hope to have solid confirmation of the principles within a year, and X-rays, if that goes well, optimistically within three years,” Soljačić says. But as with any drastically new technology, he acknowledges, the devil is in the details, and unexpected issues could crop up. So his estimate of when a practical X-ray device could emerge from this, he says with a smile, is “from three years, to never.” Hrvoje Buljan, a professor of physics at the University of Zagreb in Croatia, who was not involved in this study, says the work provides “a significant new approach to produce X-ray radiation.” He adds, “The experimental implementation still needs to be performed. Based on the proposal, all of the ingredients for the proof of principle experiments are there, and such experiments will be feasible.” The work was supported by the U.S. Army Research Laboratory and the U.S. Army Research Office, through the Institute for Soldier Nanotechnologies, by the Science and Engineering Research Council, A*STAR, Singapore, and by the European Research Council Marie Curie IOF grant.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.2.1 | Award Amount: 4.88M | Year: 2014

Divers operate in harsh and poorly monitored environments in which the slightest unexpected disturbance, technical malfunction, or lack of attention can have catastrophic consequences. They manoeuvre in complex 3D environments, carry cumbersome equipment, while performing their mission. To overcome these problems, CADDY aims to establish an innovative set-up between a diver and companion autonomous robots (underwater and surface) that exhibit cognitive behaviour through learning, interpreting, and adapting to the divers behaviour, physical state, and actions.\nThe CADDY project replaces a human buddy diver with an autonomous underwater vehicle and adds a new autonomous surface vehicle to improve monitoring, assistance, and safety of the divers mission. The resulting system plays a threefold role similar to those that a human buddy diver should have: i) the buddy observer that continuously monitors the diver; ii) the buddy slave that is the divers extended hand during underwater operations performing tasks such as do a mosaic of that area, take a photo of that or illuminate that; and iii) the buddy guide that leads the diver through the underwater environment.\nThe envisioned threefold functionality will be realized through S&T objectives which are to be achieved within three core research themes: the Seeing the Diver research theme focuses on 3D reconstruction of the diver model (pose estimation and recognition of hand gestures) through remote and local sensing technologies, thus enabling behaviour interpretation; the Understanding the Diver theme focuses on adaptive interpretation of the model and physiological measurements of the diver in order to determine the state of the diver; while the Diver-Robot Cooperation and Control theme is the link that enables diver interaction with underwater vehicles with rich sensory-motor skills, focusing on cooperative control and optimal formation keeping with the diver as an integral part of the formation.

News Article | November 24, 2015

The most widely used technology for producing X-rays — used in everything from medical and dental imaging, to testing for cracks in industrial materials — has remained essentially the same for more than a century. But based on a new analysis by researchers at MIT, that might potentially change in the next few years. The finding, based on a new theory backed by exact simulations, shows that a sheet of graphene — a two-dimensional form of pure carbon — could be used to generate surface waves called plasmons when the sheet is struck by photons from a laser beam. These plasmons in turn could be triggered to generate a sharp pulse of radiation, tuned to wavelengths anywhere from infrared light to X-rays. What’s more, the radiation produced by the system would be of a uniform wavelength and tightly aligned, similar to that from a laser beam. The team says this could potentially enable lower-dose X-ray systems in the future, making them safer. The new work is reported this week in the journal Nature Photonics, in a paper by MIT professors Marin Soljačić and John Joannopoulos and postdocs Ido Kaminer, Liang Jie Wong (now at the Singapore Institute of Manufacturing Technology), and Ognjen Ilic. Soljačić says that there is growing interest in finding new ways of generating sources of light, especially at scales that could be incorporated into microchips or that could reduce the size and cost of the high-intensity beams used for basic scientific and biomedical research. Of all the wavelengths of electromagnetic radiation commonly used for applications, he says, “coherent X-rays are particularly hard to create.” They also have the highest energy. The new system could, in principle, create ultraviolet light sources on a chip and table-top X-ray devices that could produce the sorts of beams that now require huge, multimillion-dollar particle accelerators. To make focused, high-power X-ray beams, “the usual approach is to create high-energy charged particles [using an accelerator] and ‘wiggle’ them,” says Kaminer. “The oscillations will produce X-rays. But that approach is very expensive,” and the few facilities available nationwide that can produce such beams are highly oversubscribed. “The dream of the community is to make them small and inexpensive,” he says. Most sources of X-rays rely on extremely high-energy electrons, which are hard to produce. But the new method gets around that, using the tightly-confined power of the wave-like plasmons that are produced when a specially patterned sheet of graphene gets hit by photons from a laser beam. These plasmons can then release their energy in a tight beam of X-rays when triggered by a pulse from a conventional electron gun similar to those found in electron microscopes. “The reason this is unique is that we’re substantially bypassing the problem of accelerating the electrons,” he says. “Every other approach involves accelerating the electrons. This is unique in producing X-rays from low-energy electrons.” In addition, the system would be unique in its tunability, able to deliver beams of single-wavelength light all the way from infrared, through visible light and ultraviolet, on into X-rays. And there are three different inputs that can be used to control the tuning of the output, Kaminer explains — the frequency of the laser beam to initiate the plasmons, the energy of the triggering electron beam, and the “doping” of the graphene sheet. Such beams could have applications in crystallography, the team says, which is used in many scientific fields to determine the precise atomic structure of molecules. Because of its tight, narrow beam, the system might also allow more precise pinpointing of medical and dental X-rays, thus potentially reducing the radiation dose received by a patient, they say. So far, the work is theoretical, based on precise simulations, but the group’s simulations in the past have tended to match quite well with experimental results, Soljačić says. “We have the ability in our field to model these phenomena very exactly.” They are now in the process of building a device to test the system in the lab, starting initially with producing ultraviolet sources and working up to the higher-energy X-rays. “We hope to have solid confirmation of the principles within a year, and X-rays, if that goes well, optimistically within three years,” Soljačić says. But as with any drastically new technology, he acknowledges, the devil is in the details, and unexpected issues could crop up. So his estimate of when a practical X-ray device could emerge from this, he says with a smile, is “from three years, to never.” Hrvoje Buljan, a professor of physics at the University of Zagreb in Croatia, who was not involved in this study, says the work provides “a significant new approach to produce X-ray radiation.” He adds, “The experimental implementation still needs to be performed. Based on the proposal, all of the ingredients for the proof of principle experiments are there, and such experiments will be feasible.” The work was supported by the U.S. Army Research Laboratory and the U.S. Army Research Office, through the Institute for Soldier Nanotechnologies, by the Science and Engineering Research Council, A*STAR, Singapore, and by the European Research Council Marie Curie IOF grant.

Belusic D.,University of Zagreb | Guttler I.,Meteorological and Hydrological Service
Quarterly Journal of the Royal Meteorological Society | Year: 2010

The influence of meandering flow on dispersion of pollutants is frequently under-represented in dispersion models. In terms of measurements, meandering is primarily associated with time-scales between the turbulence and the applied averaging time, which is usually 1 h. The related spatial scales thus range roughly from 102 to 104 m (referred to here as submesoscales). As the state-of-the-art mesoscale models should be capable of reproducing flow features on scales larger than the turbulence, and as the meandering-generating mechanisms are not fully understood yet, it is useful to examine if the mesoscale models can reproduce meandering. For that purpose, the WRF/Chem model at 1/3 km horizontal resolution is used to simulate a weak-wind night during the CASES99 experiment. The measurements are used for detailed model verification. The model with its typical set-up fails to reproduce the variability at submesoscales and the locus of the under-representation is traced to too-strong horizontal diffusion. Reducing or removing the model diffusion allows the appearance of the submeso variability, whose spectral properties and the resulting plume behaviour agree well with the measurements. The linear correlation between the simulations with reproduced variability and themeasurements is low, as is the case between two simulations with only slightly different set-up. The conclusion is that mesoscale models are able to reproduce the strength of variability and the effects of meandering, but only with reduced or removed horizontal diffusion. The question arises whether it is possible to obtain a linear correlation, i.e. to correctly reproduce individual modes at these scales at all. © 2010 Royal Meteorological Society.

Cindric K.,Meteorological and Hydrological Service | Pasaric Z.,University of Zagreb | Gajic-Capka M.,Meteorological and Hydrological Service
Theoretical and Applied Climatology | Year: 2010

Systematic statistical analysis of dry day sequences, which are defined according to 0.1, 1, 5 and 10 mm of precipitation-per-day thresholds, is performed on seasonal and yearly basis. The data analysed come from 25 Croatian meteorological stations and cover the period 1961-2000. Climatological features of the mean and maximum dry spell durations, as well as the frequency of long dry spells (>20 days) are discussed. The results affirm the three main climatological regions in Croatia, with the highlands exhibiting shorter dry spells than the mainland, and the coastal region exhibiting longer dry spells. The prevailing positive trend of both mean and maximal durations is detected during winter and spring seasons, while negative trend dominate in autumn for all thresholds. Positive field significant trends of mean dry spell duration with 5 and 10 mm thresholds are found during spring and the same is valid for annual maximum dry spell duration with a 10 mm threshold. It is found that the Discrete Autoregressive Moving Average (DARMA(1,1)) model can be used to estimate the probabilities of dry spells in Croatia that are up to 20-30 days long. © 2010 Springer-Verlag.

Mikus P.,Meteorological and Hydrological Service | Telisman Prtenjak M.,University of Zagreb | Strelec Mahovic N.,Meteorological and Hydrological Service
Atmospheric Research | Year: 2012

In this study, deep convective activity, identified by lightning measurements and associated favorable synoptic conditions, is analyzed. The focus was on the warm part of the year (April to October) during the period 2006-2009 over six sub-regions in Croatia. A convectively active day is defined as a day with at least ten lightning strikes over the target sub-region. The obtained dataset is used to determine the climatology of the frequency and regional distribution of convective days and their inter-month variability. The analysis shows that 56% of all examined days, i.e., every second day during the warm part of the year, are days with convective activity. The most convectively active sub-region is the North Adriatic, with 62.4% of all days in the analyzed sample. The areas eastward of 16°E exhibit a peak in convective activity in June, contrary to the more western sub-regions, which show a maximum later in the summer, from July to August. The average temporal characteristics, such as typical duration, onset and cessation of convection, are also estimated. In all sub-regions, the convective activity begins in the early afternoon and ends mostly in the evening. Nocturnal convection occurs more frequently along the Adriatic coast.In the second part of this study, the dominant large-scale weather types and upper-level flow regimes, corresponding to the convectively active days, were determined using surface and upper-levels pressure fields. The lightning flashes are frequently detected in the non-gradient pressure field (23%); in the center (18%), in the leading (15%) and in the rear (12%) parts of the cyclone; and in the front part of a trough (11%). The southwesterly upper-level flow represents the most common flow regime (38%) in the days with convective activity. Slightly less is the northeasterly flow, which occurs with a frequency of approximately 23%, and the northwesterly flow, with a frequency of 18% of all selected days. © 2011 Elsevier B.V.

Bulic I.H.,University of Zagreb | Kucharski F.,Abdus Salam International Center For Theoretical Physics
Climate Dynamics | Year: 2012

The delayed impact of winter sea-surface temperature (SST) anomalies in tropical Pacific on spring precipitation over the North Atlantic/European (NAE) region is examined using both measured and modeled data for the period 1901-2002. In an AMIP-type Atmospheric General Circulation Model (AGCM) ensemble, the observed delayed spring precipitation response in Europe to winter ENSO-related SST anomalies is well reproduced. A series of targeted AGCM/coupled GCM experiments are performed to further investigate the mechanisms for this delayed influence. It is found that late winter ENSO SST anomalies lead to the well-documented Rossby wave train arching from the Pacific into the Atlantic region. A positive (negative) ENSO event leads to a quasi-barotropic trough (ridge) in the North Atlantic region. The resulting wind and cloud changes cause anomalies in the surface heat fluxes that result in negative (positive) SST anomalies in the central North Atlantic and anomalies of the opposite sign further to the south. The SST anomalies persist into spring and the atmospheric response to these anomalies is an extension of the ENSO-induced trough (ridge) into the European region, leading to enhanced (reduced) moisture flux and low-level convergence (divergence) and thus positive (negative) precipitation anomalies. Although the signal is overall relatively weak (correlation coefficients of European spring rainfall with winter ENSO SSTs of about 0.3), a proper representation of the outlined mechanism in seasonal forecasting systems may lead to improved seasonal predictions. © 2011 Springer-Verlag.

Salkovic-Petrisic M.,University of Zagreb | Knezovic A.,University of Zagreb | Hoyer S.,University of Heidelberg | Riederer P.,University of Würzburg
Journal of Neural Transmission | Year: 2013

Experimental models that faithfully mimic the developmental pathology of sporadic Alzheimer's disease (sAD) in humans are important for testing the novel therapeutic approaches in sAD treatment. Widely used transgenic mice AD models have provided valuable insights into the molecular mechanisms underlying the memory decline but, due to the particular β-amyloid-related gene manipulation, they resemble the familial but not the sporadic AD form, and are, therefore, inappropriate for this purpose. In line with the recent findings of sAD being recognised as an insulin resistant brains state (IRBS), a new, non-transgenic, animal model has been proposed as a representative model of sAD, developed by intracerebroventricular application of the betacytotoxic drug streptozotocin (STZ-icv). The STZ-icv-treated animals (mostly rats and mice) develop IRBS associated with memory impairment and progressive cholinergic deficits, glucose hypometabolism, oxidative stress and neurodegeneration that share many features in common with sAD in humans. The therapeutic strategies (acetylcholinesterase inhibitors, antioxidants and many other drugs) that have been tested until now on the STZ-icv animal model have been reviewed and the comparability of the drugs' efficacy in this non-transgenic sAD model and the results from clinical trials on sAD patients, evaluated. © 2012 Springer-Verlag.

Mayer P.,Charles University | Harmanec P.,Charles University | Pavlovski K.,University of Zagreb
Astronomy and Astrophysics | Year: 2013

Analyses of 13 FEROS spectra from the ESO archive and 617 V-band photometric observations from the ASAS3 database allowed us to demonstrate that HD 165246 is a double-lined spectroscopic binary. As an earlier finding revealed, HD 165246 is also an eclipsing system. We were able to derive consistent orbital and light-curve solutions and all basic physical properties of the system. The period of this O8 V + B7 V binary is 4d.592706 and the semiamplitudes of the radial-velocity curves are K1 = 55.5 km s-1 and K2 = 321 km s-1. As the mass ratio is small (0.173), the secondary lines cannot be seen directly in the spectra; however the application of spectral disentangling allowed us to detect weak Balmer and He i lines of the secondary component. The primary component rotates with a high projected velocity of v sin i = 243 km s-1. A combined radial-velocity and light-curve solution led to the component masses and radii expected for the young stars of the given spectral types. Due to the high rotation velocity, the primary component might display changes in surface abundances of some elements. However, we did not find any significant differences with respect to the abundances of slowly rotating stars. © 2013 ESO.

Garcia-Camprubi M.,University of Zaragoza | Jasak H.,University of Zagreb | Fueyo N.,University of Zaragoza
Journal of Power Sources | Year: 2011

A model is presented that describes the main physical phenomena affecting in the performance of a Solid-Oxide Fuel Cell (SOFC). The implementation of the model uses an in-house algorithm in a computational fluid-dynamics (CFD) framework that may be used to optimize the SOFC operational parameters. The physical phenomena considered in the model are: (i) mass conservation: multicomponent and multimodal mass transfer in gas channels and electrodes (convection, ordinary diffusion, Knudsen diffusion); (ii) momentum conservation in the gas channels and electrodes; (iii) energy conservation: coupled heat transfer across the whole cell (gas channels, electrodes and electrolyte); (iv) electrochemistry: half-reactions are considered to take place at the electrode-electrolyte interfaces, and activation losses are computed using the general version of the Butler-Volmer equation. The main features of this CFD tool are: (i) it allows the prediction of the characteristic (I-V) curve of an H2-fed cell; (ii) it is suitable for both tubular and planar cells; (iii) it has been implemented using OpenFOAM-1.5-dev, an open-source CFD-platform based on the Finite Volume Method.The numerical results are validated with published experimental I-V curves for a hydrogen-fed anode-supported micro-tubular SOFC, and a numerical analysis of the influence of different operation conditions on the temperature distribution is performed to procure a better understanding of the heat management of the cell. © 2011 Elsevier B.V. All rights reserved.

Vecenaj Z.,University of Zagreb | De Wekker S.F.J.,University of Virginia
Quarterly Journal of the Royal Meteorological Society | Year: 2015

Stationarity is a fundamental assumption in the statistical investigation of turbulence and the development of similarity functions that are widely used in surface-layer parametrization schemes. Non-stationary time series should therefore be removed from the analysis before assessing turbulence statistics used in similarity functions. Many approaches have been developed over the years to determine non-stationarity of means and (co-)variances, but there has been no systematic investigation of the differences and similarities between the approaches. In this article, we contrast several frequently used approaches, including two statistical tests to determine trends, the determination of a non-stationarity ratio, and the determination of differences in turbulence statistics calculated for different averaging times. We apply these approaches to near-surface time series of wind and temperature collected during the Terrain-induced Rotor Experiment (T-REX). Our results show that the degree of non-stationarity varies considerably with the approach used. Investigation of the time series that are declared stationary by all the above approaches simultaneously reveals that in many cases such time series still show a behaviour indicative of intermittent turbulence, both for stable and unstable conditions. When these approaches are combined with an additional condition for the intermittency level, a rigorous approach for the detection of non-stationarity is developed. © 2015 Royal Meteorological Society.

Ahriche A.,University of Mentouri Constantine | Ahriche A.,Abdus Salam International Center For Theoretical Physics | McDonald K.L.,University of Sydney | Nasri S.,United Arab Emirates University | Picek I.,University of Zagreb
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2016

A recent paper investigated minimal RνMDM models with the type T1-iii and T3 one-loop topologies. However, the candidate most-minimal model does not possess an accidental symmetry - the scalar potential contains an explicit symmetry breaking term, rendering the dark matter unstable. We present two models that cure this problem. However, we further show that all of the proposed minimal one-loop RνMDM models suffer from a second problem - an additional source of explicit Z2 symmetry breaking in the Yukawa sector. We perform a more-general analysis to show that neutrino mass models using either the type T3 or type T1-iii one-loop topologies do not give viable minimal dark matter candidates. Consequently, one-loop models of neutrino mass with minimal dark matter do not appear possible. Thus, presently there remains a single known (three-loop) model of neutrino mass that gives stable dark matter without invoking any new symmetries. © 2016 .

Herceg-Bulic I.,University of Zagreb | Kucharski F.,Abdus Salam International Center For Theoretical Physics
Journal of Climate | Year: 2014

In this paper a potential seasonally lagged impact of the wintertime North Atlantic Oscillation (NAO) on the subsequent spring climate over the European region is explored. Supported by the observational indication of the wintertime NAO-spring climate connection, a modeling approach is used that employs the International Centre for Theoretical Physics (ICTP) atmospheric general circulation model (AGCM) as a stand-alone model and that is also coupled with a mixed layer ocean in the North Atlantic. Both observational and modeled data indicate a pattern of sea surface temperatures (SSTs) in North Atlantic as a possible link between wintertime NAO and climate anomalies in the following spring. The SST pattern is associated with wintertime NAO and persists through the following spring. It is argued that these SST anomalies can affect the springtime atmospheric circulation and surface conditions over Europe. The atmospheric response is recognized in observed as well as in modeled data (mean sea level pressure, temperature, and precipitation). Additionally, an impact on springtime storm activity is found as well. It is demonstrated that the SST anomalies associated with wintertime NAO persist into the subsequent spring. These SST anomalies enable atmosphere-ocean interaction over the North Atlantic and consequently affect the climate variability over Europe. Although it has a relatively weak impact, the described mechanism provides a temporal teleconnection between the wintertime NAO and subsequent spring climate anomalies. © 2014 American Meteorological Society.

Jablan M.,ICFO - Institute of Photonic Sciences | Jablan M.,University of Zagreb | Chang D.E.,ICFO - Institute of Photonic Sciences
Physical Review Letters | Year: 2015

We show that graphene possesses a strong nonlinear optical response in the form of multiplasmon absorption, with exciting implications in classical and quantum nonlinear optics. Specifically, we predict that graphene nanoribbons can be used as saturable absorbers with low saturation intensity in the far-infrared and terahertz spectrum. Moreover, we predict that two-plasmon absorption and extreme localization of plasmon fields in graphene nanodisks can lead to a plasmon blockade effect, in which a single quantized plasmon strongly suppresses the possibility of exciting a second plasmon. © 2015 American Physical Society.

Juranic M.,University of Regensburg | Juranic M.,University of Zagreb | Srilunchang K.-O.,Keygene N.V | Krohn N.G.,University of Sao Paulo | And 3 more authors.
Plant Cell | Year: 2013

Germline and early embryo development constitute ideal model systems to study the establishment of polarity, cell identity, and asymmetric cell divisions (ACDs) in plants. We describe here the function of the MATH-BTB domain protein MAB1 that is exclusively expressed in the germ lineages and the zygote of maize (Zea mays). mab1 (RNA interference [RNAi]) mutant plants display chromosome segregation defects and short spindles during meiosis that cause insufficient separation and migration of nuclei. After the meiosis-to-mitosis transition, two attached nuclei of similar identity are formed in mab1 (RNAi) mutants leading to an arrest of further germline development. Transient expression studies of MAB1 in tobacco (Nicotiana tabacum) Bright Yellow-2 cells revealed a cell cycle-dependent nuclear localization pattern but no direct colocalization with the spindle apparatus. MAB1 is able to form homodimers and interacts with the E3 ubiquitin ligase component Cullin 3a (CUL3a) in the cytoplasm, likely as a substrate-specific adapter protein. The microtubule-severing subunit p60 of katanin was identified as a candidate substrate for MAB1, suggesting that MAB1 resembles the animal key ACD regulator Maternal Effect Lethal 26 (MEL-26). In summary, our findings provide further evidence for the importance of posttranslational regulation for asymmetric divisions and germline progression in plants and identified an unstable key protein that seems to be involved in regulating the stability of a spindle apparatus regulator(s). © 2012 American Society of Plant Biologists.

Sokol Jurkovic R.,Meteorological and Hydrological Service | Pasaric Z.,University of Zagreb
International Journal of Climatology | Year: 2013

This study assesses the variability of the amounts of annual precipitation in global land areas (excluding Greenland and Antarctica) from 1951 to 2000. The analysis is based on 0.5° longitude/latitude gridded data. Three different data sets were analysed (University of East Anglia Climate Research Unit's (UEA CRU) TS 2.1 data set, the Global Precipitation Climatology Centre's (GPCC) Full Data Reanalysis version 5 data set, Variability Analysis of Surface Climate Observations (VASClimO) version 1.1 data set), and all led to very similar results. The results included here correspond to the VasClimO project data. Precipitation variability is examined through the anomaly of the coefficient of variation, which is shown to be a robust concept. It is defined as the departure of the actual coefficient of variation from the value that could be expected 'on average', conditioned on the total annual amount of precipitation. A brief discussion of the so-called Jackknife error is included. The analysis revealed diverse areas of larger-than-normal, smaller-than-normal and close-to-normal variability. Negative anomalies occur more often but have, on an average, lower values than do positive anomalies. Large areas of slightly negative anomalies were found inland for all continents except Australia. A zonal pattern in the distribution of the anomalies was clearly seen at subtropical latitudes, which generally showed positive anomalies. This general picture is modified by various local factors, such as cold ocean currents, monsoon activity and cyclone formation areas. Global modes of climate variability, such as the El Niño-Southern Oscillation (ENSO) and the Madden-Julian Oscillation (MJO), affect the variability of precipitation either directly or by modifying other relevant atmospheric and oceanic processes. Their influence is seen in many areas with higher-than-normal variability and is especially true if the high variability is accompanied by large amounts of mean annual precipitation. The authors believe that the present methodology may be useful in assessing the quality of future global data sets. It is, however, very desirable that such data sets include interpolation error estimates. © 2012 Royal Meteorological Society.

Krohn N.G.,University of Regensburg | Krohn N.G.,University of Sao Paulo | Lausser A.,University of Regensburg | Juranic M.,University of Regensburg | And 2 more authors.
Developmental Cell | Year: 2012

Unlike in animals, female gametes of flowering plants are not the direct products of meiosis but develop from a functional megaspore after three rounds of free mitotic divisions. After nuclei migration and positioning, the eight-nucleate syncytium differentiates into the embryo sac, which contains two female gametes as well as accessory cells at the micropylar and chalazal pole, respectively. We report that an egg-cell-specific gene, ZmEAL1, is activated at the micropylar pole of the eight-nucleate syncytium. ZmEAL1 translation is restricted to the egg cell, resulting in the generation of peptide-containing vesicles directed toward its chalazal pole. RNAi knockdown studies show that ZmEAL1 is required for robust expression of the proliferation-regulatory gene IG1 at the chalazal pole of the embryo sac in antipodal cells. We further show that ZmEAL1 is required to prevent antipodal cells from adopting central cell fate. These findings show how egg cells orchestrate differentiation of the embryo sac. © 2012 Elsevier Inc.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SST.2008.4.1.1. | Award Amount: 4.02M | Year: 2009

The increase in world trade has largely contributed to the explosion in sea traffic. As a result, the market demand is leading to Ultra Large Container Ships (ULCS), which have a capacity up to 14,000 TEU with length up to 400 m, without changes of the operational requirements (speed around 27 knots). The particular structural design of the container ships, leads to open midship sections, resulting in increased sensitivity to torsional and horizontal bending loads which is much more complex to model. At the same time, due to their large dimensions, the ULCS become much softer and their structural natural frequencies become significantly lower so that the global hydroelastic structural responses (springing & whipping) can become a critical issue in the ship design and should be properly modelled by the simulation tools. On the other hand, it appears that the existing simulation tools do not provide the definite answer to all these design issues and there is a clear need for their improvement. The particular importance of whipping and the insufficient knowledge in its modelling is clearly reflected in the recent MAIB (Marine Accident Investigation Branch) report, following the loss of theMSC Napoli container ship: It is likely that the hull of MSC Napoli was subjected to additional load due to whipping. it is apparent that whipping effect is currently very difficult to reliably calculate or model. In view of the potential increase in wave loading due to whipping effect, further research is required to ensure that the effect is adequately accounted for in ship design and structural analyses, and that sufficient allowance is made for the effect when determining design margins. The final goal of the project is to deliver clearly validated design tools and guidelines, capable of analysing all hydro-structure interaction problems relevant to ULCS.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2012.2.4.5-2 | Award Amount: 8.55M | Year: 2012

Inflammatory bowel diseases affect 0.8% of the Europeans, and are associated with high morbidity, definite mortality and an increasing economic burden. Current diagnostic tools and therapeutics for IBD are unsatisfactory. Development of biomarkers allowing insights into pathogenesis, prognosis and targeted therapy is a major unmet need. This programme addresses that need. IBD-BIOM is a multidisciplinary consortium of leading academic and industrial SME researchers in inflammatory bowel disease, genomics, glycomics, glycoproteomics and activomics. Recent genome-wide association studies performed by IBD-BIOM partners have identified nearly 100 genes associated with IBD, but clinical application of these is so far limited. IBD-BIOM will capitalise on its existing high quality clinical, genetic, biochemical and immunological data and biological samples on over 6000 very well characterised IBD patients and controls by exploiting novel technological approaches made available through the expertise and global leading position of IBD-BIOM partners. These comprise cutting edge epigenetic, glycomic, glycoproteomic and activomic approaches which were all previously reported to be associated with inflammation and disturbances to the immune system. The inclusion of these complementary analyses in the diagnostics of IBD should also facilitate elucidation of pathways through which environmental exposures influence IBD risk and progression. A complex systems biology approach will be used to integrate, interrogate and understand this multidimensional dataset to identify novel early diagnostic and prognostic biomarkers and new targets for therapeutic intervention. The track record of achievement of IBD-BIOM partners coupled to the central and leading positions of the research-intensive SME partners in IBD-BIOM is a strong indication that the ambitions work programme will be achieved and a framework to facilitate swift conversion of research discoveries into commercial products.

Agency: Cordis | Branch: FP7 | Program: BSG-SME | Phase: SME-2011-1 | Award Amount: 912.11K | Year: 2011

A team of 3 SMEs, coordinated by a young woman entrepreneur, proposes a new concept for salvage operations of distressed ships at sea. The proposed concept, called CART (Cooperative Autonomous Robotic Towing system) is based on the development of robotised unmanned marine platforms able to (semi-)automatically execute the high risk operation of linking the emergency towing system of distressed ships to towing vessels. The CART device will be able to optimise the operations for safeguarding the environment, helping to prevent oil pollution at sea, and minimising the risk for human lives. The SME participants, thanks to their know-how in emergency towing devices and salvage operations, as well as in the implementation of automation plants, can formulate and validate new concepts of intervention and contribute to the development of critical sub-systems. Anyway, for bridging the gap between the formulation of an operational concept and its in-field validation with a prototype tool in a time compatible with time-to-market requirements, the SME participants need the transfer of know-how from experienced RTD performers operating in the area of robotics and unmanned marine vehicles, as well as the application of qualification procedures for new technologies. Thus, two European leading research and academic institutions in the field of marine robotics and one of the worlds leading classification societies have been involved in the project as RTD developers. They will also perform extended training of SMEP personnel in order to provide them with the needed know-how to execute the follow-up activities of engineering and manufacturing of the CART system. Technologies based on robotised unmanned marine vehicles combined with the coming into force of international safety rules, that will make mandatory for the global fleet the use of emergency towing devices, can play a game-changing role in the field of salvage intervention at sea opening significant business opportunities.

Barisic S.,University of Zagreb | Barisic O.S.,Institute of Physics
Journal of Superconductivity and Novel Magnetism | Year: 2012

Large U d theories of high-T c cuprates often start from the ionic limit in which one charge per cuO2 unit cell is localized on the copper site and involved in AF correlations with neighboring sites. AF correlations are promoted by a relatively small exchange J and the motion of holes by is described by the t-J models with narrow effective bands. However, very small hole doping is sufficient to destabilize the Mott-AF phase and the resulting metallic phase explicitly exhibits comparatively wide covalent bands. After a brief description of the large U d ionic limit, the large U d covalent limit is therefore considered. It is shown that in this limit, the large U d produces a reasonably small effective kinematic interaction between two holes on oxygens. This interaction gives rise to magnetic correlations, similar to those found in the weak-coupling Hubbard theories. The distinct signature of large U d is the broadening of the single (and two) particle properties of the system, which is related to the "mixed valence fluctuations" between Cu and 2O, localized within the CuO 2 unit cell. These fluctuations produce a sizeable Landau-like damping of the single (and two) particle propagations, thus competing with the magnetic coherence, characterized by an incommensurate wave-vector. The cuprates appear to fall between these two extreme limits, which might explain in part why they are so difficult to understand. © Springer Science+Business Media, LLC 2012.

Alebic M.S.,Podobnik Maternity and Gynecology Hospital | Stojanovic N.,University of Zagreb | Duhamel A.,University of Lille Nord de France | Dewailly D.,Service de Gynecologie Endocrinienne et Medecine de la Reproduction
Human Reproduction | Year: 2015

STUDY QUESTION: Is intrinsic dysregulation of granulosa cells (GC) and consequent increases in the per-follicle production of anti-Müllerian hormone (AMH), correlated with the phenotypic presentation of women with polycystic ovaries? SUMMARY ANSWER: Involvement of intrinsic GC dysregulation in oligo-anovulation associated with polycystic ovary syndrome (PCOS) is likely because among women with PCOS, those with oligo-amenorrhea have higher per-follicle AMH production than those who ovulate normally, irrespective of their androgen and/or metabolic status. WHAT IS KNOWN ALREADY: Women with PCOS have higher serum AMH level than non-PCOS women due to an increased follicle number and excessive AMH production per follicle, the latter reflecting a putative GC dysfunction that may vary between PCOS phenotypes. STUDY DESIGN, SIZE, DURATION: This is a retrospective analysis of data collected from 1021 women undergoing infertility evaluation from March 2011 to October 2013. PARTICIPANTS/MATERIALS, SETTING, METHODS: The study included women with polycystic ovarian morphology (PCOM) who met the Rotterdam criteria for PCOS (n = 272), women with PCOM only (n = 168) and controls (n = 581). MAIN RESULTS AND THE ROLE OF CHANCE: We used serum AMH to antral follicle count (AFC) ratio (AMH/AFC) as a marker of per-follicle AMH production and checked whether this ratio was associated with the PCOS phenotype and to the menstrual, androgen and metabolic status in women with PCOS, women with PCOM only and in controls. AMH/AFC was significantly higher in oligo-amenorrheic women with PCOS than in eumenorrheic women with PCOS or PCOM (P < 0.001) but also in the latter group compared with controls (P < 0.001) regardless of androgen status. Stepwise discriminant analysis yielded a significant score for the menstrual status with a discriminant power of 26.5% (P < 0.001). This score included AFC, AMH/AFC, waist circumference and LH with partial R2 of 0.172, 0.042, 0.024 and 0.023, respectively. LIMITATIONS, REASONS FOR CAUTION: The AMH to AFC ratio as a surrogate marker for average AMH may be subject to error because follicles below the sensitivity limit of the ultrasonography used may also contribute to serum AMH concentration and secondly, AFC can be subjective. WIDER IMPLICATIONS OF THE FINDINGS: The higher AMH/AFC in women with PCOM only than in controls suggests that isolated PCOM may represent a PCOS-like phenotype in which an inherent dysfunction of GC exists but is too mild to affect the ovulatory process. STUDY FUNDING/COMPETING INTEREST(S): No funding was obtained for this study. There are no conflicts of interest to be declared. TRIAL REGISTRATION NUMBER: Non-applicable. © The Author 2015. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.

Milanovic Z.,University of Niš | Sporis G.,University of Zagreb | Weston M.,University of Teesside
Sports Medicine | Year: 2015

Background: Enhancing cardiovascular fitness can lead to substantial health benefits. High-intensity interval training (HIT) is an efficient way to develop cardiovascular fitness, yet comparisons between this type of training and traditional endurance training are equivocal. Objective: Our objective was to meta-analyse the effects of endurance training and HIT on the maximal oxygen consumption (VO2max) of healthy, young to middle-aged adults. Methods: Six electronic databases were searched (MEDLINE, PubMed, SPORTDiscus, Web of Science, CINAHL and Google Scholar) for original research articles. A search was conducted and search terms included ‘high intensity’, ‘HIT’, ‘sprint interval training’, ‘endurance training’, ‘peak oxygen uptake’, and ‘VO2max’. Inclusion criteria were controlled trials, healthy adults aged 18–45 years, training duration ≥2 weeks, VO2max assessed pre- and post-training. Twenty-eight studies met the inclusion criteria and were included in the meta-analysis. This resulted in 723 participants with a mean ± standard deviation (SD) age and initial fitness of 25.1 ± 5 years and 40.8 ± 7.9 mL·kg−1·min−1, respectively. We made probabilistic magnitude-based inferences for meta-analysed effects based on standardised thresholds for small, moderate and large changes (0.2, 0.6 and 1.2, respectively) derived from between-subject SDs for baseline VO2max. Results: The meta-analysed effect of endurance training on VO2max was a possibly large beneficial effect (4.9 mL·kg−1·min−1; 95 % confidence limits ±1.4 mL·kg−1·min−1), when compared with no-exercise controls. A possibly moderate additional increase was observed for typically younger subjects (2.4 mL·kg−1·min−1; ±2.1 mL·kg−1·min−1) and interventions of longer duration (2.2 mL·kg−1·min−1; ±3.0 mL·kg−1·min−1), and a small additional improvement for subjects with lower baseline fitness (1.4 mL·kg−1·min−1; ±2.0 mL·kg−1·min−1). When compared with no-exercise controls, there was likely a large beneficial effect of HIT (5.5 mL·kg−1·min−1; ±1.2 mL·kg−1·min−1), with a likely moderate greater additional increase for subjects with lower baseline fitness (3.2 mL·kg−1·min−1; ±1.9 mL·kg−1·min−1) and interventions of longer duration (3.0 mL·kg−1·min−1; ±1.9 mL·kg−1·min−1), and a small lesser effect for typically longer HIT repetitions (−1.8 mL·kg−1·min−1; ±2.7 mL·kg−1·min−1). The modifying effects of age (0.8 mL·kg−1·min−1; ±2.1 mL·kg−1·min−1) and work/rest ratio (0.5 mL·kg−1·min−1; ±1.6 mL·kg−1·min−1) were unclear. When compared with endurance training, there was a possibly small beneficial effect for HIT (1.2 mL·kg−1·min−1; ±0.9 mL·kg−1·min−1) with small additional improvements for typically longer HIT repetitions (2.2 mL·kg−1·min−1; ±2.1 mL·kg−1·min−1), older subjects (1.8 mL·kg−1·min−1; ±1.7 mL·kg−1·min−1), interventions of longer duration (1.7 mL·kg−1·min−1; ±1.7 mL·kg−1·min−1), greater work/rest ratio (1.6 mL·kg−1·min−1; ±1.5 mL·kg−1·min−1) and lower baseline fitness (0.8 mL·kg−1·min−1; ±1.3 mL·kg−1·min−1). Conclusion: Endurance training and HIT both elicit large improvements in the VO2max of healthy, young to middle-aged adults, with the gains in VO2max being greater following HIT when compared with endurance training. © 2015, Springer International Publishing Switzerland.

Pasalic D.,University of Zagreb | Marinkovic N.,Quintiles | Feher-Turkovic L.,University of Zagreb
Biochemia Medica | Year: 2012

With considering serum concentration of the uric acid in humans we are observing hyperuricemia and possible gout development. Many epidemiological studies have shown the relationship between the uric acid and different disorders such are obesity, metabolic syndrome, hypertension and coronary artery disease. Clinicians and investigators recognized serum uric acid concentration as very important diagnostic and prognostic factor of many multifactorial disorders. This review presented few clinical conditions which are not directly related to uric acid, but the concentrations of uric acid might have a great impact in observing, monitoring, prognosis and therapy of such disorders. Uric acid is recognized as a marker of oxidative stress. Production of the uric acid includes enzyme xanthine oxidase which is involved in producing of radical-oxigen species (ROS). As by-products ROS have a significant role in the increased vascular oxidative stress and might be involved in atherogenesis. Uric acid may inhibit endothelial function by inhibition of nitric oxide-function under conditions of oxidative stress. Down regulation of nitric oxide and induction of endothelial dysfunction might also be involved in pathogenesis of hypertension. The most important and well evidenced is possible predictive role of uric acid in predicting short-term outcome (mortality) in acute myocardial infarction (AMI) patients and stroke. Nephrolithiasis of uric acid origin is significantly more common among patients with the metabolic syndrome and obesity. On contrary to this, uric acid also acts is an "antioxidant", a free radical scavenger and a chelator of transitional metal ions which are converted to poorly reactive forms.

Joksimovic G.M.,University of Montenegro | Riger J.,University of Montenegro | Wolbank T.M.,Vienna University of Technology | Peric N.,University of Zagreb | Vasak M.,University of Zagreb
IEEE Transactions on Industrial Electronics | Year: 2013

Before applying current-signature-analysis-based monitoring methods, it is necessary to thoroughly analyze the existence of the various harmonics on healthy machines. As such an analysis is only done in very few papers, the objective of this paper is to make a clear and rigorous characterization and classification of the harmonics present in a healthy cage rotor induction motor spectrum as a starting point for diagnosis. Magnetomotive force space harmonics, slot permeance harmonics, and saturation of main magnetic flux path through the virtual air-gap permeance variation are taken into analytical consideration. General rules are introduced giving a connection between the number of stator slots, rotor bars, and pole pairs and the existence of rotor slot harmonics as well as saturation-related harmonics in the current spectrum. For certain combinations of stator and rotor slots, saturation-related harmonics are shown to be most prominent in motors with a pole pair number of two or more. A comparison of predicted and measured current harmonics is given for several motors with different numbers of pole pairs, stator slots, and rotor bars. © 1982-2012 IEEE.

Szajewska H.,Medical University of Warsaw | Ruszczynski M.,Medical University of Warsaw | Kolacek S.,University of Zagreb
Acta Paediatrica, International Journal of Paediatrics | Year: 2014

A meta-analysis of four randomised controlled trials of varying methodological quality, involving 304 children aged 1-48 months, showed that Lactobacillus acidophilus LB (LB) reduced the duration of diarrhoea in hospitalised, but not outpatient, children compared with a placebo. The chance of a cure on day three was similar in both groups, but LB increased the chance of cure on day four. Conclusion There is limited evidence to recommend LB for treating paediatric diarrhoea. ©2013 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd.

Dolar D.,University of Zagreb | Kosutic K.,University of Zagreb | Vucic B.,Djacka 10
Desalination | Year: 2011

The fertilizer industry generates effluents with large amounts of fluoride and phosphate. The objective of this study was to investigate the removal efficiency of reverse osmosis (RO) and nanofiltration (NF) membranes to reduce fluoride and phosphate load to less than 8mgL-1 and 2mgL-1, respectively. Separation membranes were characterized indirectly by solute transport method determining pore size and pore size distribution in the selective membranes' layer. The characterization showed unimodal pore size distributions (PSDs) for RO membranes (LFC, ULP and XLE) and tight NF membrane (NF90) with most pores of 0.70nm and 0.82nm, respectively. Completely different PSD had the loose NF membrane, HL, which was bimodal with two clearly separated peaks. The presented laboratory study indicated that the rejections of fluoride with RO membranes were higher than 80% (model waters) and higher than 96% (real wastewater), and with NF membranes higher than 40%. Rejections of phosphates were higher: >95% (model waters) and >97% (real wastewater). RO/NF emerged as the promising processes to effectively remove fluoride and phosphate from fertilizer wastewater and meet all MCLS according to the Croatian law. © 2010 Elsevier B.V.

Tomljenovic D.,University of Zagreb | Pinter D.,Sunce | Kalogjera L.,University of Zagreb
Allergy and Asthma Proceedings | Year: 2014

Chronic stress exposure carries greater risk of onset of atopic respiratory disorders such as rhinitis and asthma. The interaction between depression, anxiety, and severity of chronic rhinosinusitis (CRS) has been suggested. We aimed to access the relationship between psychological stress, severity of CRS, and atopy. Sixty-three consecutive patients referred with CRS were asked to score the severity of rhinosinusitis symptoms on a visual analog scale and to fill in questionnaires on the disease-specific quality of life and perceived stress-22-item Sino-Nasal Outcome Test (SNOT-22) and measure of perceived stress (MPS) scale, respectively. Inclusion criteria for the study were a reliable allergy evaluation and a recent computerized tomography (CT) scan of the sinuses. Patients with nasal polyps (NPs), asthma, and previous surgery were excluded. The study group consisted of 14 allergic and 18 nonallergic patients with CRS without NPs (CRSsNPs). Correlation between MPS and SNOT-22 scores in the study group was highly significant (Pearson r = 0.61; p = 0.001). Patients with higher stress scores had significantly stronger postnasal discharge, thick discharge, cough, disturbed sleep, fatigue, and sadness. Postnasal drip was significantly stronger in patients with allergy. The correlation between SNOT-22 and CT scores was insignificant. The correlation between MPS and SNOT-22 scores suggests an interaction between severity of CRS and chronic stress, but not with the extent of the disease on CT in CRSsNPs. Chronic psychological stress might be one of the factors that modifies the disease severity and may lead to uncontrolled disease in CRS patients. Copyright © 2014, OceanSide Publications, Inc., U.S.A.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SSH-2007-5.2-01 | Award Amount: 1.87M | Year: 2009

IME investigates European identities, defined as a wide range of definitions of us, the Europeans proposed and acted upon by various actors in and around the current European Union (EU), in particular in nine cases: Bulgaria, Croatia, Finland, France, Germany, Greece, Hungary, Turkey, and the United Kingdom. Drawing from the theory of multiple modernities, the project addresses three major issues regarding European identities: what they are, in what ways they have been formed and what trajectories they may take from now on. Through a set of nine case studies, IME first investigates the diversity of European identities as it manifests in the nine cases. It then examines the various ways in which these diverse self-definitions have been formulated and maintained in different societal, cultural and systemic settings and in which they have been interacting with various processes and forces. It then aims to identify commonalities among diverse European identities in nine countries through a series of thematic comparisons of the cases, in order to provide the basis for grounded projection of possible trajectories European identities may take as the processes of European integration continue. The project challenges the conventional wisdom about European identities and the teleological implication which lies behind much of the discussions of European identities and aims to offer valuable insights into the contexts in which various policies of identity construction are pursued.

Topic: ACTION-Grid is a Specific International Cooperation Project on healthcare information systems based on Grid capabilities and Biomedical Informatics (BMI) between Latin America, the Western Balkans and the European Union (EU). Background: Members of the consortium have published pioneering scientific papers in Grid and BMI. They participated in the BIOINFOMED and SYMBIOMATICS studies that contributed decisively to the last two FPs of the EC. Main objective: ACTION-Grid will act as a multiplier of previous outcomes in Grid and BMI. ACTION-Grid will disseminate these outcomes in Latin America, the Western Balkans and North Africa. Sub-objectives: (1) To survey Grid-based and BMI initiatives in Europe, Latin America, the Western Balkans and North Africa. These results will be combined with data from an inventory of Grid/Nano/BMI methods and services, developed by the consortium. (2) Based on previous EC-based projects, ACTION-Grid will foster training and mobility in Grid and BMI. (3) To develop a White Paper, in collaboration with a panel of recognized experts. This document will be delivered to the EC to establish a future agenda covering the Grid/Nano/Bio/Medical Informatics areas and develop new plans in Latin America, the Western Balkans and North Africa. (4) To disseminate ACTION-Grid, by means of: (a) An international symposium on Grid and BMI. This conference will be carried out in Europe, with two satellite conferences (b) Scientific publications, (c) Dissemination strategies, such as a Website, Newsletters, Press releases, etc. Expected impact: To expand previous initiatives to create a common health information infrastructure in Europe, and extending it to other regions. It will enhance cooperation between research centres, universities, hospitals, SMEs, public entities, and others. ACTION-Grid will expand the impact of EC achievements in Grid and BMI to researchers, educators, and health practitioners world-wide.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: SPA-2007-1.1-02;SPA-2007-2.1-01 | Award Amount: 5.16M | Year: 2008

The proposed project realizes a wide synergy in the fields of solar- space- and geophysics to achieve a higher level of processed data and better understanding of solar and space events having terrestrial impact. The study of these events has an increasing importance with the increasing amount of technical equipment (e.g. power lines and telecommunication satellites) that can be damaged during these events. The project mobilizes more than 50 experts and significant resources from EU (including new EU member states) for the process, analysis, and interpretation of a large set of relevant data of more than 20 satellites (including 5 ESA missions) and the complementing ground-based data. It aims at providing better data bases and new methods to access and analyze them. The new databases go beyond the present state-of-the-art in details, and their on-line publication facilitates fast access to the open data acquired during these missions. The data will be further connected with new theoretical and simulation models and their usage will provide the expected impact of improvement of the scientific results that can be obtained from collected space data. The outputs will provide a long-term dissemination contributing to a higher level space monitoring system, and more reliable space weather forecast ability. In the proposal all the aspects are related to the effective exploitation of scientific data from space missions. The project fulfills the expectations of Work Program on space science by developing tools to archive, access and process the data, and realizing research as downstream R&D activities complementing space missions, in such a field where a strong need for further scientific analysis of data can be demonstrated. The set of deliverables enhances the effectiveness and productivity of the European scientific community in terms of usage of this data. The research work will be accompanied with educational and SME-related activities as well as public events.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.6.7 | Award Amount: 4.54M | Year: 2012

The architecture of the ICT infrastructure for supporting Intelligent Transportation Systems (ITS) is purely hierarchical, with sensed data flowing from the leaves (i.e., road-side or vehicle-installed sensors) to the root (i.e., the traffic management centre). The current approach does not scale adequately with the inclusion of a significant number of new elements, is not flexible in supporting an incremental growth or changes of the ITS, and exhibits latency and security issues. In ICSE we tackle all these issues by proposing a new architecture where the intelligence for sensing and actuation is distributed over some of the elements, called gateways, which host a software platform for running ITS applications, using the local storage and computation capabilities available. Communication with the remote centre happens only for the transmission of aggregated data for long-term operations, e.g., data mining, software upgrades, and logging.\nThe approach proposed in ICSE enables scientific and technological innovations: advanced sensing algorithms will be defined, which make use of real-time availability of data; efficient distribution of context-rich data lays the foundations for novel traffic and travel management strategies. Both directions will be studied in the project. However, research challenges are associated at all levels to the realization of the system, especially for the communication among sensors, gateways, and vehicles, which are fully addressed in the project activities. Prototypes of sensors, road-side units, and communication units suitable for the cooperative operation envisaged in ICSE will be developed and integrated into an end-to-end demonstrator, which will be used in on-field experiments for the use cases of smart urban traffic management and accident recovery in highway.

Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: REGPOT-2007-3-01 | Award Amount: 412.83K | Year: 2008

Experimental nuclear physics is one of the top research activities at the Ruer Bokovi Institute (RBI), the largest Croatian research center in science and applications. The RBI nuclear physics group has strong link with the research group at the University of Zagreb (UoZ). RBI scientists perform experiments at the RBI Tandem accelerator facility and at the top EU experimental facilities in collaboration with the prominent EU research groups in the field, including partners from the Laboratori Nazionali del Sud INFN (INFN-LNS), Catania, Italy and the Nuclear Physics Group from the University of Birmingham (UoB), UK. With this project we propose to strengthen scientific relationships, the exchange of know-how and sharing of experience between RBI, UoZ, INFN-LNS and UoB partners in the research field of our mutual interest, focusing on the studies of nuclear molecules and other areas at the forefront of research for new phenomena in nuclear physics. This will be achieved by: (i) reinforcement of RBI experimental capabilities through the upgrade of the local experimental facility, (ii) exchange of personnel between partner institutions, hiring and training of young staff at accelerator facilities, (iii) organization of workshops. Upgraded research infrastructure for low energy measurements at RBI and complementary facility at INFN-LNS for intermediate energy measurements through this partnership would increase research opportunities for even broader European experimental nuclear physics community.

The finding, based on a new theory backed by exact simulations, shows that a sheet of graphene – a two-dimensional form of pure carbon – could be used to generate surface waves called plasmons when the sheet is struck by photons from a laser beam. These plasmons in turn could be triggered to generate a sharp pulse of radiation, tuned to wavelengths anywhere from infrared light to X-rays. What's more, the radiation produced by the system would be of a uniform wavelength and tightly aligned, similar to that from a laser beam. The team says this could potentially enable lower-dose X-ray systems in the future, making them safer. The new work is reported this week in the journal Nature Photonics, in a paper by MIT professors Marin Soljačić and John Joannopoulos and postdocs Ido Kaminer, Liang Jie Wong (now at the Singapore Institute of Manufacturing Technology), and Ognjen Ilic. Soljačić says that there is growing interest in finding new ways of generating sources of light, especially at scales that could be incorporated into microchips or that could reduce the size and cost of the high-intensity beams used for basic scientific and biomedical research. Of all the wavelengths of electromagnetic radiation commonly used for applications, he says, "coherent X-rays are particularly hard to create." They also have the highest energy. The new system could, in principle, create ultraviolet light sources on a chip and table-top X-ray devices that could produce the sorts of beams that now require huge, multimillion-dollar particle accelerators. To make focused, high-power X-ray beams, "the usual approach is to create high-energy charged particles [using an accelerator] and 'wiggle' them," says Kaminer. "The oscillations will produce X-rays. But that approach is very expensive," and the few facilities available nationwide that can produce such beams are highly oversubscribed. "The dream of the community is to make them small and inexpensive," he says. Most sources of X-rays rely on extremely high-energy electrons, which are hard to produce. But the new method gets around that, using the tightly-confined power of the wave-like plasmons that are produced when a specially patterned sheet of graphene gets hit by photons from a laser beam. These plasmons can then release their energy in a tight beam of X-rays when triggered by a pulse from a conventional electron gun similar to those found in electron microscopes. "The reason this is unique is that we're substantially bypassing the problem of accelerating the electrons," he says. "Every other approach involves accelerating the electrons. This is unique in producing X-rays from low-energy electrons." In addition, the system would be unique in its tunability, able to deliver beams of single-wavelength light all the way from infrared, through visible light and ultraviolet, on into X-rays. And there are three different inputs that can be used to control the tuning of the output, Kaminer explains – the frequency of the laser beam to initiate the plasmons, the energy of the triggering electron beam, and the "doping" of the graphene sheet. Such beams could have applications in crystallography, the team says, which is used in many scientific fields to determine the precise atomic structure of molecules. Because of its tight, narrow beam, the system might also allow more precise pinpointing of medical and dental X-rays, thus potentially reducing the radiation dose received by a patient, they say. So far, the work is theoretical, based on precise simulations, but the group's simulations in the past have tended to match quite well with experimental results, Soljačić says. "We have the ability in our field to model these phenomena very exactly." They are now in the process of building a device to test the system in the lab, starting initially with producing ultraviolet sources and working up to the higher-energy X-rays. "We hope to have solid confirmation of the principles within a year, and X-rays, if that goes well, optimistically within three years," Soljačić says. But as with any drastically new technology, he acknowledges, the devil is in the details, and unexpected issues could crop up. So his estimate of when a practical X-ray device could emerge from this, he says with a smile, is "from three years, to never." Hrvoje Buljan, a professor of physics at the University of Zagreb in Croatia, who was not involved in this study, says the work provides "a significant new approach to produce X-ray radiation." He adds, "The experimental implementation still needs to be performed. Based on the proposal, all of the ingredients for the proof of principle experiments are there, and such experiments will be feasible." More information: Liang Jie Wong et al. Towards graphene plasmon-based free-electron infrared to X-ray sources, Nature Photonics (2015). DOI: 10.1038/nphoton.2015.223

Ilakovac A.,University of Zagreb | Pilaftsis A.,University of Manchester | Popov L.,University of Zagreb
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

We study charged lepton flavor violation in low-scale seesaw models of minimal supergravity, which realize large neutrino Yukawa couplings thanks to approximate lepton-number symmetries. There are two dominant sources of lepton flavor violation in such models. The first source originates from the usual soft supersymmetry-breaking sector, whilst the second one is entirely supersymmetric and comes from the supersymmetric neutrino Yukawa sector. Within the framework of minimal supergravity, we consider both sources of lepton flavor violation, soft and supersymmetric, and calculate a number of possible lepton-flavor- violating transitions, such as the photonic decays of muons and taus, μ→eγ, τ→eγ and τ→μγ, their neutrinoless three-body decays, μ→eee, τ→eee, τ→μμμ, τ→eeμ and τ→eμμ, and the coherent μ→e conversion in nuclei. After taking into account the exclusion bounds placed by present experiments of lepton flavor violation, we derive combined theoretical limits on the universal heavy Majorana mass scale mN and the light-to-heavy neutrino mixings. Supersymmetric low-scale seesaw models offer distinct correlated predictions for lepton-flavor-violating signatures, which might be discovered in current and projected experiments, such as MEG, COMET/PRISM, Mu2e, super-BELLE and LHCb. © 2013 American Physical Society.

Lipozencic J.,Academy of Medical science of Croatia | Hadzavdic S.L.,University of Zagreb
Clinics in Dermatology | Year: 2014

Perioral dermatitis is a relatively common inflammatory facial skin disorder that predominantly affects women. It is rarely diagnosed in children. A typical perioral dermatitis presentation involves the eruption of papules and pustules that may recur over weeks to months, occasionally with fine scales. The differential diagnosis includes seborrheic dermatitis, systemic lupus erythematosus, acne vulgaris, lupus miliaris disseminatus faciei, polymorphous light eruption, steroidinduced rosacea, granulomatous perioral dermatitis, contact dermatitis (allergic and irritant), and even basal cell carcinoma. The histopathology is similar to that of rosacea, with a perivascular and perifollicular lymphohistiocytic infiltrate and sebaceous hyperplasia. The etiology of perioral dermatitis is unknown, but the uncritical use of topical corticosteroids often precedes skin lesions. Physical sunscreens with high sun protection factors may cause perioral dermatitis in children. © 2014 Elsevier Inc.

Cvetesic N.,University of Zagreb | Palencia A.,French National Center for Scientific Research | Halasz I.,Ruder Boskovic Institute | Cusack S.,French National Center for Scientific Research | Gruic-Sovulj I.,University of Zagreb
EMBO Journal | Year: 2014

The fidelity of protein synthesis depends on the capacity of aminoacyl-tRNA synthetases (AARSs) to couple only cognate amino acid-tRNA pairs. If amino acid selectivity is compromised, fidelity can be ensured by an inherent AARS editing activity that hydrolyses mischarged tRNAs. Here, we show that the editing activity of Escherichia coli leucyl-tRNA synthetase (EcLeuRS) is not required to prevent incorrect isoleucine incorporation. Rather, as shown by kinetic, structural and in vivo approaches, the prime biological function of LeuRS editing is to prevent mis-incorporation of the non-standard amino acid norvaline. This conclusion follows from a reassessment of the discriminatory power of LeuRS against isoleucine and the demonstration that a LeuRS editing-deficient E. coli strain grows normally in high concentrations of isoleucine but not under oxygen deprivation conditions when norvaline accumulates to substantial levels. Thus, AARS-based translational quality control is a key feature for bacterial adaptive response to oxygen deprivation. The non-essential role for editing under normal bacterial growth has important implications for the development of resistance to antimicrobial agents targeting the LeuRS editing site. © 2014 The Authors.

Bukac M.,University of Houston | Canic S.,University of Houston | Glowinski R.,University of Houston | Glowinski R.,University Pierre and Marie Curie | And 2 more authors.
Journal of Computational Physics | Year: 2013

We present a new model and a novel loosely coupled partitioned numerical scheme modeling fluid-structure interaction (FSI) in blood flow allowing non-zero longitudinal displacement. Arterial walls are modeled by a linearly viscoelastic, cylindrical Koiter shell model capturing both radial and longitudinal displacement. Fluid flow is modeled by the Navier-Stokes equations for an incompressible, viscous fluid. The two are fully coupled via kinematic and dynamic coupling conditions. Our numerical scheme is based on a new modified Lie operator splitting that decouples the fluid and structure sub-problems in a way that leads to a loosely coupled scheme which is unconditionally stable. This was achieved by a clever use of the kinematic coupling condition at the fluid and structure sub-problems, leading to an implicit coupling between the fluid and structure velocities. The proposed scheme is a modification of the recently introduced " kinematically coupled scheme" for which the newly proposed modified Lie splitting significantly increases the accuracy. The performance and accuracy of the scheme were studied on a couple of instructive examples including a comparison with a monolithic scheme. It was shown that the accuracy of our scheme was comparable to that of the monolithic scheme, while our scheme retains all the main advantages of partitioned schemes, such as modularity, simple implementation, and low computational costs. © 2012 Elsevier Inc.

Kodiah Beyeh N.,University of Jyväskylä | Cetina M.,University of Jyväskylä | Cetina M.,University of Zagreb | Rissanen K.,University of Jyväskylä
Chemical Communications | Year: 2014

The first examples of halogen bonded analogues of deep cavity cavitands with guest binding properties, formed between N-alkyl ammonium resorcinarene halides as acceptors and bromotrichloromethane as the donor, are reported in the solid state and in solution. © 2014 The Royal Society of Chemistry.

Dodig S.,Srebrnjak Childrens Hospital | Cepelak I.,University of Zagreb
Biochemia Medica | Year: 2013

Over the past three decades, the goal of many researchers is analysis of exhaled breath condensate (EBC) as noninvasively obtained sample. A total quality in laboratory diagnostic processes in EBC analysis was investigated: pre-analytical (formation, collection, storage of EBC), analytical (sensitivity of applied methods, standardization) and post-analytical (interpretation of results) phases. EBC analysis is still used as a research tool. Limitations referred to pre-analytical, analytical, and post-analytical phases of EBC analysis are numerous, e.g. low concentrations of EBC constituents, single-analyte methods lack in sensitivity, and multi-analyte has not been fully explored, and reference values are not established. When all, preanalytical, analytical and post-analytical requirements are met, EBC biomarkers as well as biomarker patterns can be selected and EBC analysis can hopefully be used in clinical practice, in both, the diagnosis and in the longitudinal follow-up of patients, resulting in better outcome of disease. © Croatian Society of Medical Biochemistry and Laboratory Medicine.

Jug M.,University of Zagreb | Kosalec I.,University of Zagreb | Maestrelli F.,University of Florence | Mura P.,University of Florence
Journal of Pharmaceutical and Biomedical Analysis | Year: 2011

Interaction in solution and in the solid state of triclosan (TR), a practically water-insoluble antimicrobial agent, with parent β-cyclodextrin (βCD) and its water-soluble epichlorohydrin polymer (EPI-βCD) was investigated by several analytical techniques, to evaluate the role of the carrier features on the physicochemical properties of the drug-cyclodextrin complex. Phase-solubility studies showed the higher solubilizing and complexing ability of EPI-βCD (Ks=11,733M-1) than parent βCD (Ks=2526M-1). Actual inclusion complex formation between TR and both cyclodextrins tested was confirmed by 2D 1H NMR studies (ROESY), which also gave insight into some different drug/cyclodextrin binding modes between polymeric and parent βCD. Addition of hydrophilic polymers (hydroxypropylcellulose, hypromellose or amidated pectin) to TR/βCD systems increased βCD solubilizing efficacy, but, unexpectedly, decreased its complexing ability towards the drug. Solid binary and ternary samples prepared by co-grinding of components in high energy mills were carefully characterised by Differential Scanning Calorimetry, X-ray powder diffractometry and Fourier transform infrared spectroscopy. The results pointed out the higher affinity of EPI-βCD than βCD for the interaction with TR even in the solid state, resulting in the formation of completely amorphous products with superior dissolution properties. Addition of hydrophilic polymers failed to effectively promote solid-state interactions between TR and βCD, while their positive influence on drug solubility, observed in phase-solubility studies, was absent in solid TR/βCD/polymer products. Finally, the time-kill analysis, used to evaluate the TR antimicrobial activity against Streptococcus mutans, demonstrated the significantly (p<0.001) superior performance of both cyclodextrin complexes than drug alone, and confirmed the higher effectiveness (p<0.05) of TR/EPI-βCD than TR/βCD complex. © 2010 Elsevier B.V.

Otmacic Curkovic H.,University of Zagreb | Stupnisek-Lisac E.,University of Zagreb | Takenouti H.,University Pierre and Marie Curie
Corrosion Science | Year: 2010

The aim of this work is to establish the correlation between the solution pH and the inhibiting efficiency of two imidazole compounds (4-methyl-1-phenyl imidazole and 4-methyl-1-(p-tolyl) imidazole) in protection of copper from corrosion in chloride media. It was found that the inhibiting efficiency of both studied imidazoles enhances with the increase of the solution pH value, from about 20% in 0.5 M HCl to 92% in 0.5 M NaCl. This improvement was ascribed to stronger adsorption of neutral imidazole molecule, which can be expected at higher pH values, than that of the protonated imidazole cation, which may be expected in acid solutions. © 2009 Elsevier Ltd. All rights reserved.

Margetic B.,Neuropsychiatric Hospital Dr Ivan Barbo | Margetic B.A.,University of Zagreb
Pharmacoepidemiology and Drug Safety | Year: 2010

Purpose: Neuroleptic malignant syndrome (NMS) is a rare and life threatening condition usually defined as a complication of treatment with antipsychotics characterized by severe rigidity, tremor, fever, altered mental status, autonomic dysfunction, and elevated serum creatine phosphokinase and white blood cell count. The literature on this topic is rather extensive, but many aspects related to the syndrome are thought to be controversial. The aim of this paper, written with the clinician in mind, is to summarize some of the most prominent controversies that may have importance in usual clinical practice. Methods: The literature was searched for reviews, reports on the series of cases, individual case reports of NMS, and other clinically and theoretically important information. Results: There are controversies associated with virtually all important aspects of NMS. At the moment, it is not clear if this drug reaction is idiosyncratic or not, what diagnostic criteria are the most appropriate for usual clinical practice, and it seems that the estimated incidence is not in accordance with the number of treated patients. There are rather different approaches to the pathophysiological mechanisms, differential diagnosis, and treatment. Conclusions: Some of the controversies related to NMS have an influence on our understanding of the condition and may have importance in clinical practice. There is a need for further research that should elucidate these controversies. Copyright © 2010 John Wiley & Sons, Ltd.

Doslia T.,University of Zagreb | Reti T.,Széchenyi István University | Vukicevic D.,University of Split
Chemical Physics Letters | Year: 2011

We introduce a family of invariants defined in terms of positive functions of degrees of vertices in a graph. A member of the family that measures the average degree of neighbors of vertices in a graph is then investigated for the predictive potential for stability in the class of generalized fullerenes. © 2011 Elsevier B.V. All rights reserved.

Simic L.,University of Zagreb | Sarabon N.,University of Primorska | Markovic G.,University of Zagreb
Scandinavian Journal of Medicine and Science in Sports | Year: 2013

We applied a meta-analytical approach to derive a robust estimate of the acute effects of pre-exercise static stretching (SS) on strength, power, and explosive muscular performance. A computerized search of articles published between 1966 and December 2010 was performed using PubMed, SCOPUS, and Web of Science databases. A total of 104 studies yielding 61 data points for strength, 12 data points for power, and 57 data points for explosive performance met our inclusion criteria. The pooled estimate of the acute effects of SS on strength, power, and explosive performance, expressed in standardized units as well as in percentages, were -0.10 [95% confidence interval (CI): -0.15 to -0.04], -0.04 (95% CI: -0.16 to 0.08), and -0.03 (95% CI: -0.07 to 0.01), or -5.4% (95% CI: -6.6% to -4.2%), -1.9% (95% CI: -4.0% to 0.2%), and -2.0% (95% CI: -2.8% to -1.3%). These effects were not related to subject's age, gender, or fitness level; however, they were more pronounced in isometric vs dynamic tests, and were related to the total duration of stretch, with the smallest negative acute effects being observed with stretch duration of ≤45s. We conclude that the usage of SS as the sole activity during warm-up routine should generally be avoided. © 2012 John Wiley & Sons A/S.

Delic R.,General Hospital | Stefanovic M.,University of Zagreb
Journal of Maternal-Fetal and Neonatal Medicine | Year: 2010

This study was undertaken to investigate the usefulness of standard biochemical and hematological parameters measurement at third trimester of pregnancy for the individual prediction of preeclampsia. Methods. A retrospective designed study included 113 patients with preeclampsia and a control group of 95 normal, uncomplicated pregnancies. Patients were recruited in the third trimester of pregnancy at the Department of Gynecology and Obstetrics, General Hospital Celje, Slovenia, EU. Erythrocytes, leukocytes, thrombocytes, hemoglobin, hematocrit, aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transferase, alkaline phosphatase, total bilirubin, urea, creatinine, uric acid, body mass index, parity, and age were evaluated to predict the occurrence of preeclampsia based on multivariate logistic regression model. Results. When parameters such as uric acid and urea were included into logistic regression model, we correctly classified 79.6% patients. With additional four parameters (thrombocytes, hematocrit, aspartate aminotransferase and leukocytes) we correctly classified 83.8% patients with preeclampsia. Conclusion. Our findings confirmed that several standard biochemical and hematological parameters, when used as laboratory test panel have significant prognostic value in the prediction of preeclampsia. © 2010 Informa UK Ltd.

Jakupovic A.,Polytechnic of Rijeka | Pavlic M.,University of Rijeka | Han Z.D.,University of Zagreb
Expert Systems with Applications | Year: 2014

This paper describes a method of knowledge representation as a set of text expressed statements. The method is based on the identification of word-categories/phrases and their semantic relationships within the observed statement. Furthermore, the identification of semantic relationships between words/phrases using wh-questions that clarify the role of the word/phrase in the relationship is described. A conceptual model of the computer system based on the formalization method of text-expressed knowledge is proposed. The subsystem text formalization is described in detail, especially its parts: syntactic analysis of the sentence, sentence formalization, phrase structure grammar and lexicon. The phrase structure grammar is formed by induction and it is used to generate the language of the formalized notation of a sentence. The derivation of grammar is based on the simple phrase structure grammar which was used for the syntactical analysis of informal language notation. In its base, the suggested method translates sentences of the informal language into formal language sentences which are generated by the derivated phrase structure grammar. Current limitations of the method that also set the path of its further development are shown. Next concrete steps in the development of the method are also described. © 2014 Elsevier Ltd. All rights reserved.

Marusic K.,University of Zagreb | Curkovic H.O.,University of Zagreb | Takenouti H.,French National Center for Scientific Research
Electrochimica Acta | Year: 2011

Bronze statues exposed to an urban area suffer corrosion processes induced by acid rainwater. Use of corrosion inhibitors is one of the most convenient and cost-effective techniques to mitigate it. In a previous work, it was found that 4-methyl-1-p-tolylimidazole (MTI) is non-toxic and efficient inhibitor of copper, and thus we will examine the anticorrosive effect of this substance to copper-tin bronze. First, with bare Cu-6Sn (wt%) bronze, inhibiting efficiency in artificial acid rainwater in urban environment was evaluated by Tafel extrapolation, polarization resistance, and electrochemical impedance spectroscopy (EIS) methods. This study showed that all three methods supply similar inhibiting efficiency validating thus the use of EIS, the least invasive method. This study was followed by the evaluation of inhibiting effect on patinated bronze in sulphate medium. A quntitative study about the inhibiting effect on patinated bronze is scarcely reported in the literature. EIS data revealed three capacitive loops. Comparison with EIS obtained in bare specimens allowed attributing the additional capacitive loop located at the highest frequency domain to the dielectric property of the patina layer. The impedance modulus determined in presence of MTI increased markedly with immersion time, revealing a protective effect of this non-toxic corrosion inhibitor. © 2011 Elsevier Ltd. All rights reserved.

Ananthanarayanan V.,Max Planck Institute of Molecular Cell Biology and Genetics | Schattat M.,Max Planck Institute of Molecular Cell Biology and Genetics | Schattat M.,Martin Luther University of Halle Wittenberg | Vogel S.K.,Max Planck Institute of Molecular Cell Biology and Genetics | And 6 more authors.
Cell | Year: 2013

Summary Cytoplasmic dynein is a motor protein that exerts force on microtubules. To generate force for the movement of large organelles, dynein needs to be anchored, with the anchoring sites being typically located at the cell cortex. However, the mechanism by which dyneins target sites where they can generate large collective forces is unknown. Here, we directly observe single dyneins during meiotic nuclear oscillations in fission yeast and identify the steps of the dynein binding process: from the cytoplasm to the microtubule and from the microtubule to cortical anchors. We observed that dyneins on the microtubule move either in a diffusive or directed manner, with the switch from diffusion to directed movement occurring upon binding of dynein to cortical anchors. This dual behavior of dynein on the microtubule, together with the two steps of binding, enables dyneins to self-organize into a spatial pattern needed for them to generate large collective forces. © 2013 Elsevier Inc.

Pavin N.,University of Zagreb | Tolic-Norrelykke I.M.,Max Planck Institute of Molecular Cell Biology and Genetics
Biochemical Society Transactions | Year: 2013

To exert forces, motor proteins bind with one end to cytoskeletal filaments, such as microtubules and actin, and with the other end to the cell cortex, a vesicle or another motor. A general question is how motors search for sites in the cell where both motor ends can bind to their respective binding partners. In the present review, we focus on cytoplasmic dynein, which is required for a myriad of cellular functions in interphase, mitosis and meiosis, ranging from transport of organelles and functioning of the mitotic spindle to chromosome movements in meiotic prophase. We discuss how dynein targets sites where it can exert a pulling force on the microtubule to transport cargo inside the cell. © 2013 Biochemical Society.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.2.2 | Award Amount: 3.55M | Year: 2010

Lack of sufficient linguistic resources for many languages and domains currently is one of the major obstacle in further advancement of automated translation. The main goal of the ACCURAT research is to find, analyze and evaluate novel methods how comparable corpora can compensate for this shortage of linguistic resources to improve MT quality significantly for under-resourced languages and narrow domains.\nThe ACCURAT project will provide researchers and developers with novel methodology and fully functional model for exploiting comparable corpora to increase translation quality of existing and emerging MT systems.\nWe will determine criteria to measure the comparability of texts in comparable corpora. Methods for automatic acquisition of a comparable corpus from the Web will be analyzed and evaluated. Advanced techniques will be elaborated to extract lexical, terminological and other linguistic data from comparable corpora to provide training and customization data for MT. Improvements from applying acquired data will be measured against baseline results from MT systems and validated in practical applications.\nACCURAT will provide novel approaches to achieve high quality MT translation for a number of under-resourced EU languages (e.g. Estonian, Croatian) and to adapt existing MT technologies to narrow domains (e.g. automotive engineering), significantly increasing the language and domain coverage of MT. ACCURAT methods will be universal and adaptable to new languages and domains.\nThe project consortium has an optimum balance of world-class researchers in all key research areas and industry SME participants ensuring maximum orientation to exploitation needs.\nThe ACCURAT will provide contribution for expected impacts of the Call by providing methods for automatic acquisition and annotation of language resources, removing gaps in language coverage and increasing quality of translation and providing methods for automated translation to make it more adaptive.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SPA.2011.2.1-01 | Award Amount: 2.52M | Year: 2012

The consortium e-HEROES aims at exploiting the existing data gathered on several European and international space missions, and to produce new value-added data products to provide the best estimate and prediction of the threats that missions of exploration will encounter in reaching beyond the Earth orbit, to the Moon, to Mars and beyond. The scope of the project is to characterise the environment in space, to provide useful information for planning and implementing space missions, manned or robotic. We plan to realize effective scientific exploitation of space data combining different datasets from current solar system robotic explorations with data from current and past space-based and complementing ground-based observations, joined with new data sources from the newest missions. We plan to add value to the data by better organising it and cross link it, by applying state of the art models and developing new ones to analyse it. We plan additionally to assimilate the heliospheric data in space environment simulations. The wealth of data, models and simulations commanded by the project will be used to characterise the evolution of space in time, looking forward over the future at the possible scenarios for planning new missions. We will consider key aspects on how the expected space environment can affect missions, in terms of predicting the impact on reliability and correct functionality of instrumentation as well as in terms of main radiation components affecting the health of astronauts. The proposing team would realize a wide international synergy in the fields of solar and space physics including experts from 11 European countries, a space-faring partner from Russia, and collaborators from US and Canada. The set of public deliverables published on-line facilitates access to the higher level data for those scientists who are not part of the team. The research work will be accompanied with wide dissemination activity.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.6.3 | Award Amount: 4.65M | Year: 2012

Improving the efficiency of water management in Europe was recognised by the EC as essential for overcoming the growing exposure of European countries to Water Scarcity and Droughts. UrbanWater proposes a platform that will enable a better end-to-end water management in urban areas, accounting for 17% of freshwater consumption in the EU.\nThe project will undertake the development, demonstration, and economic up-scaling of an innovative ICT-based platform for the efficient integrated management of water resources. The system will benefit end-users, utilities, public authorities, the environment and the general public, in terms of: (i) providing consumers with comprehensive tools enabling them to use water more efficiently thereby reducing overall consumption; (ii) helping water utilities to meet demand at reduced costs; and (iii) fostering new partnerships between water authorities, utility, equipment and software companies so as to ensure the successful commercialisation of the system and the evolution of the European water sector as a global leader.\nThe system will incorporate advanced metering solutions, real-time communication of consumption data and new data management technologies with real-time predictive capability, demand forecasting, consumption pattern interpretation, decision support systems, adaptive pricing and user empowerment solutions.\nThe UrbanWater consortium includes ICT companies, research organisations, water utilities and authorities with complementary capacities and all the know-how required to oversee the successful completion of the project. Two water distributors included in the group will undertake large-scale validations with their urban users, thus promoting a final outcome that is close to the market and to the end-users.\nThe final outcome of the project will remain open and interoperable with energy and water management schemes, thus positively impacting not only water consumption, but overall usage of natural resources across Europe.

Agency: Cordis | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-2012-IAPP | Award Amount: 1.05M | Year: 2013

Abu-MaTran seeks to enhance industry-academia cooperation as a key aspect to tackle one of Europes biggest challenges: multilinguality. We aim to increase the hitherto low industrial adoption of machine translation by identifying crucial cutting-edge research techniques (automatic acquisition of corpora and linguistic resources, pivot techniques, linguistically augmented statistical translation and diagnostic evaluation), preparing them to be suitable for commercial exploitation and finally transferring this knowledge to industry. On the other hand, we will transfer back to academia the know-how of industry regarding management, processes, etc. to make research products more robust. The project exploits the open-source business model, all the resources produced will be released as free/open-source software, resulting in effective knowledge transfer beyond the consortium. The consortium is made up of first-line partners in their fields of research, they have complementary areas of expertise which will be exploited in order to create and develop lasting synergies. The core activity regards transfer of knowledge. This is carried out mainly by means of secondments, which put in contact academic and industrial partners. Secondments are complemented by recruited staff, which will be in charge of gathering the knowledge transfer and implementing it at the hosts in the longer term. We work on a case study of strategic interest for Europe; we provide machine translation for the language of a new member state (Croatian) and then extend to related languages of candidate member states. The project has a strong emphasis on dissemination, through the organisation of workshops that focus on intersectoral knowledge transfer. Finally, we have a comprehensive outreach plan, including the establishment of a national Linguistic Olympiad, open-day activities for students and the participation in Google Summer of Code.

Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2010.10.2-1 | Award Amount: 2.94M | Year: 2010

The quest for clean and renewable energy sources found tremendous potential in wind power. So far, it has been harvested mostly by wind towers, which use only wind currents close to the ground (bellow 200m of height). Since low altitude wind currents are slow and intermittent, most wind farms operate, on average, 25-35% of their capacity. This represents a severe limitation to current state-of-art wind power technology, as towers can hardly be taller than 130m without prohibitive costs and insurmountable technical difficulties. To bypass these difficulties, it is proposed to perform R&D in a multitude of technology fields such as materials, aerodynamics and control, further developing a wind power system capable of harnessing the energy potential of high altitude wind without the need for heavy towers or expensive elevated nacelles: we call it HAWE (High Altitude Wind Energy). HAWE consists of a buoyant, rotating, cylinder shaped, airship, anchored to a ground station by a tether cable operating a two phase cycle. During the power production phase the Magnus effect on the rotating cylinder generates lift, pulling up the tether cable which, at the ground station, is in a winch drum driving a flywheel connected to an alternator producing electricity. When the tether cable is fully unwound, the recovery phase starts - as the cylinder rotation ceases and the cable is reeled back to its initial position decoupled from the flywheel, completing a cycle. This is performed continuously. The successful implementation of this concept will increase the share of renewable energy in Europe since, the achievement of the goal to produce renewable energy at competitive prices with coal derived energy, should lower its cost. A high security of supply, a cleaner environment, and the possibility to keep Europe as a global leader in wind power, are other benefits of this technology.

Agency: Cordis | Branch: H2020 | Program: CSA | Phase: H2020-TWINN-2015 | Award Amount: 989.73K | Year: 2016

This project is an innovative opportunity to mend several gaps in the research capacity in Croatia in Archaeology, Genetics, and other Sciences of the Past by twinning a consortium of Croatian researchers (CrEAMA Initiative) with archaeological scientists from the University of Cambridge (UCAM) and the University of Pisa (UP). The project exploits location-specific advantages that arise from two crucial facts. Firstly, there is large number of archaeological sites and remains in Croatia that are relatively understudied. Secondly there is a group of researchers (CrEAMA Initiative) whose research capacity, impact, and grant success at the European level has not realised full potential owing to a relative lack of resources, coordination, and strategic planning. This project will unlock this latent scientific potential by developing multi-inter-trans- disciplinary (MIT disciplinary) expertise. Our ultimate vision is to develop a research group capable of using an MIT disciplinary approach to Sciences of the Past; this will be a powerful force for innovation and will contribute to resolving contemporary issues. This vision will be realised through support from our partners: the UCAM and the UP. Both institutions display success in Archaeology, Genetics and other Sciences of the Past, and have proven track records in applying for and completing EU-funded research projects. The first goal is to establish and integrate the existing MIT disciplinary scientific research community in Croatia. The second goal is to upgrade and intensify scientific research of CrEAMA Initiative by utilising recent methodological achievements in genetics (NGS) and other biological disciplines (GMM). The third goal is to foster integration of the CrEAMA Initiative into ERA. Our last goal is to commercialise and integrate the CrEAMA Initiative research with the needs of society (local community) at the local (Korula Island), regional (Dalmatia), national, European (web) and global (web) level.

Huang H.,Johns Hopkins University | Huang H.,University of Texas Southwestern Medical Center | Vasung L.,University of Zagreb
International Journal of Developmental Neuroscience | Year: 2014

Human brain is extraordinarily complex and yet its origin is a simple tubular structure. Its development during the fetal period is characterized by a series of accurately organized events which underlie the mechanisms of dramatic structural changes during fetal development. Revealing detailed anatomy at different stages of human fetal brain development provides insight on understanding not only this highly ordered process, but also the neurobiological foundations of cognitive brain disorders such as mental retardation, autism, schizophrenia, bipolar and language impairment. Diffusion tensor imaging (DTI) and histology are complementary tools which are capable of delineating the fetal brain structures at both macroscopic and microscopic levels. In this review, the structural development of the fetal brains has been characterized with DTI and histology. Major components of the fetal brain, including cortical plate, fetal white matter and cerebral wall layer between the ventricle and subplate, have been delineated with DTI and histology. Anisotropic metrics derived from DTI were used to quantify the microstructural changes during the dynamic process of human fetal cortical development and prenatal development of other animal models. Fetal white matter pathways have been traced with DTI-based tractography to reveal growth patterns of individual white matter tracts and corticocortical connectivity. These detailed anatomical accounts of the structural changes during fetal period may provide the clues of detecting developmental and cognitive brain disorders at their early stages. The anatomical information from DTI and histology may also provide reference standards for diagnostic radiology of premature newborns. © 2013 ISDN.

Zic T.,University of Zagreb | Vrsnak B.,University of Zagreb | Temmer M.,University of Graz
Astrophysical Journal, Supplement Series | Year: 2015

The so-called drag-based model (DBM) simulates analytically the propagation of coronal mass ejections (CMEs) in interplanetary space and allows the prediction of their arrival times and impact speeds at any point in the heliosphere ("target"). The DBM is based on the assumption that beyond a distance of about 20 solar radii from the Sun, the dominant force acting on CMEs is the "aerodynamic" drag force. In the standard form of DBM, the user provisionally chooses values for the model input parameters, by which the kinematics of the CME over the entire Sun-"target" distance range is defined. The choice of model input parameters is usually based on several previously undertaken statistical studies. In other words, the model is used by ad hoc implementation of statistics-based values of the input parameters, which are not necessarily appropriate for the CME under study. Furthermore, such a procedure lacks quantitative information on how well the simulation reproduces the coronagraphically observed kinematics of the CME, and thus does not provide an estimate of the reliability of the arrival prediction. In this paper we advance the DBM by adopting it in a form that employs the CME observations over a given distance range to evaluate the most suitable model input parameters for a given CME by means of least-squares fitting. Furthermore, the new version of the model automatically responds to any significant change of the conditions in the ambient medium (solar wind speed, density, CME-CME interactions, etc.) by changing the model input parameters according to changes in the CME kinematics. The advanced DBM is shaped in a form that can be readily employed in an operational system for real-time space-weather forecasting by promptly adjusting to a successively expanding observational data set, thus providing a successively improving prediction of the CME arrival. © 2015. The American Astronomical Society. All rights reserved.

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