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Wolverhampton, United Kingdom

The University of Wolverhampton is a British university located on four campuses across the West Midlands, Shropshire and Staffordshire. The city campus is located in Wolverhampton city centre, with a second campus at Walsall and a third in Telford. There is an additional fourth campus in Wolverhampton at the University of Wolverhampton Science Park. The university also operates a Health Education Centre in Burton-upon-Trent for nursing students.The institution was known as Wolverhampton Polytechnic before gaining university status in 1992. Its roots lie in the 19th-century growth of the Wolverhampton Mechanics’ Institute ; the Wolverhampton Free Library ; and the School of Art, established in 1851, which came together as the Wolverhampton and Staffordshire Technical College in 1931.The university has seven academic schools/faculties and several cross-disciplinary research centres and institutes.It has approximately 23,000 students and currently offers over 380 undergraduate and postgraduate courses.The university is noted for its success in encouraging wider participation in higher education. Wikipedia.

In England, there have been 40 years of area-based initiatives (ABIs) involving strategic national government intervention in local authority areas with significant regeneration needs. Whilst they have been examined individually, less consideration has been given to the layering and legacy of ABIs. Uncertainties include whether local authorities have institutionalised new ways of operating or whether layering complexities have acted as significant barriers. Focusing on Wolverhampton, in the West Midlands, this paper examines recent ABI experiences and discusses why support for City Challenge (1992-98) appeared stronger than the more recent New Deal for Communities programme (2001-11). Important ABI legacies include greater diversity of neighbourhood structures, anxiety towards ABIs where property markets are depressed and the realisation that, whilst partnership working has intensified, traditional exclusionary aspects remain. Achieving the most effective governance structures to facilitate urban regeneration remains an on-going challenge, including within emerging Coalition government policy frameworks. © 2011 Urban Studies Journal Limited.

Jopling M.,University of Wolverhampton
Journal of Computer Assisted Learning | Year: 2012

This paper outlines the findings of a review that examined the literature around current practice in one-to-one online tuition in schools and higher education. It summarizes the purposes, contexts, scope, and methods of 17 core studies identified through a systematic literature search. It then uses a conceptual framework focusing on pedagogical innovation to explore the findings of the core studies, a discussion that is also informed by the consideration of a number of contextual studies exploring group online tuition and online learning more generally. The paper concludes by suggesting that the development of one-to-one online tuition has been constrained by comparisons with face-to-face approaches and that more research is needed to map its characteristics and potential in more detail as technology continues to evolve. © 2011 Blackwell Publishing Ltd.

Thelwall M.,University of Wolverhampton
Scientometrics | Year: 2012

In theory, the web has the potential to provide information about the wider impact of academic research, beyond traditional scholarly impact. This is because the web can reflect non-scholarly uses of research, such as in online government documents, press coverage or public discussions. Nevertheless, there are practical problems with creating metrics for journals based on web data: principally that most such metrics should be easy for journal editors or publishers to manipulate. Nevertheless, two alternatives seem to have both promise and value: citations derived from digitised books and download counts for journals within specific delivery platforms. © 2012 Akadémiai Kiadó, Budapest, Hungary.

Do cell penetrating peptides (CPPs) translocate into spermatozoa and, if so, could they be utilized to deliver a much larger protein cargo? Chemically diverse polycationic CPPs rapidly and efficiently translocate into spermatozoa. They exhibit differential accumulation within intracellular compartments without detrimental influences upon cellular viability or motility but they are relatively ineffective in transporting larger proteins. Endocytosis, the prevalent route of protein internalization into eukaryotic cells, is severely compromised in mature spermatozoa. Thus, the translocation of many bioactive agents into sperm is relatively inefficient. However, the delivery of bioactive moieties into mature spermatozoa could be significantly improved by the identification and utility of an efficient and inert vectorial delivery technology. CPP translocation efficacies, their subsequent differential intracellular distribution and the influence of peptides upon viability were determined in bovine spermatozoa. Temporal analyses of sperm motility in the presence of exogenously CPPs utilized normozoospermic human donor samples. CPPs were prepared by manual, automated and microwave-enhanced solid phase synthesis. Confocal fluorescence microscopy determined the intracellular distribution of rhodamine-conjugated CPPs in spermatozoa. Quantitative uptake and kinetic analyses compared the translocation efficacies of chemically diverse CPPs and conjugates of biotinylated CPPs and avidin. 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) conversion assays were employed to analyse the influence of CPPs upon sperm cell viability and sperm class assays determined the impact of CPPs on motility in capacitated and non-capacitated human samples. Chemically heterogeneous CPPs readily translocated into sperm to accumulate within discrete intracellular compartments. Mitoparan (INLKKLAKL(Aib)KKIL), for example, specifically accumulated within the mitochondria located in the sperm midpiece. The unique plasma membrane composition of sperm is a critical factor that directly influences the uptake efficacy of structurally diverse CPPs. No correlations in efficacies were observed when comparing CPP uptake into sperm with either uptake into fibroblasts or direct translocation across a phosphatidylcholine membrane. These comparative investigations identified C105Y (CSIPPEVKFNKPFVYLI) as a most efficient pharmacokinetic modifier for general applications in sperm biology. Significantly, CPP uptake induced no detrimental influence upon either bovine sperm viability or the motility of human sperm. As a consequence of the lack of endocytotic machinery, the CPP-mediated delivery of much larger protein complexes into sperm is relatively inefficient when compared with the similar process in fibroblasts. It is possible that some CPPs could directly influence aspects of sperm biology and physiology that were not analysed in this study. CPP technologies have significant potential to deliver selected bioactive moieties and so could modulate the biology and physiology of human sperm biology both prior- and post-fertilization.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: MG-7.1-2014 | Award Amount: 5.97M | Year: 2015

Transportation sector undergoes a considerable transformation as it enters a new landscape where connectivity is seamless and mobility options and related business models are constantly increasing. Modern transportation systems and services have to mitigate problems emerging from complex mobility environments and intensive use of transport networks including excessive CO2 emissions, high congestion levels and reduced quality of life. Due to the saturation of most urban networks, innovative solutions to the above problems need to be underpinned by collecting, processing and broadcasting an abundance of data from various sensors, systems and service providers. Furthermore, such novel transport systems have to foresee situations in near real time and provide the means for proactive decisions, which in turn will deter problems before they even emerge. Our vision is to provide the required interoperability, adaptability and dynamicity in modern transport systems for a proactive and problem-free transportation system. OPTIMUM will establish a largely scalable, distributed architecture for the management and processing of multisource big-data, enabling continuous monitoring of transportation systems needs and proposing proactive decisions and actions in an (semi-) automatic way. OPTIMUM follows a cognitive approach based on the Observe, Orient, Decide, Act loop of the big data supply chain for continuous situational awareness. OPTIMUMs goals will be achieved by incorporating and advancing state of the art in transport and traffic modeling, travel behavior analysis, sentiment analysis, big data processing, predictive analysis and real-time event-based processing, persuasive technologies and proactive recommenders. The proposed solution will be deployed in real-life pilots in order to realise challenging use cases in the domains of proactive improvement of transport systems quality and efficiency, proactive charging for freight transport and Car2X communication integration.

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