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Milwaukee, WI, United States

The University of Wisconsin–Milwaukee is a public urban research university located in Milwaukee, Wisconsin, in the United States. It is the largest university in the Milwaukee metropolitan area and a member of the University of Wisconsin System. It is also one of the two doctoral degree-granting public universities and the second largest university in Wisconsin.The University of Wisconsin–Milwaukee has a total student enrollment of 27,813 and 1,623 faculty members. It is located in Milwaukee's upper East Side close to Lake Michigan, and is home to the only graduate school of freshwater science in the U.S., the largest School of Architecture, College of Nursing, and College of Health science in the State of Wisconsin. The University consists of 14 schools and colleges, and 70 academic centers, institutes and laboratory facilities. It offers a total of 181 degree programs, including 94 bachelor's, 53 master's and 33 doctorate degrees.The university is categorized as an RU/H Research University in the Carnegie Classification of Institutions of Higher Education. In the year 2010, the university had a total research expenditure of 68 million US Dollars ranked 179th among US research universities by total research expenditure in 2010.The university's athletic teams are called the Panthers. A total of 15 Panther athletic teams compete in NCAA Division I. Panthers have won the James J. McCafferty Trophy as the Horizon League's all-sports champions six times since 2000 and are the reigning champions. Milwaukee also passed Notre Dame for the all-time lead in Horizon League Championships with 128. Wikipedia.

Nambisan S.,University of Wisconsin - Milwaukee
Journal of the Association of Information Systems | Year: 2013

In this paper, I follow up on my previous article about information systems as a reference discipline for new product development (Nambisan, 2003) and assess the extant research on this topic. To facilitate the assessment, I develop a framework that considers information technology's (IT's) dual roles as operand resource and as operant resource and its impact on innovation process and on innovation outcome. My analysis reveals the advance that has been made in understanding IT's role as operand resource in innovation and the considerable opportunity that exists to explore IT's emerging role as operant resource in innovation. I also comment on the need for IS scholars working in this area to make careful choices regarding their research topic and theoretical perspectives to enhance the potential impact on and contribution to the product/service innovation literature. Source

Lu Y.,Pfeiffer University | Ramamurthy K.,University of Wisconsin - Milwaukee
MIS Quarterly: Management Information Systems | Year: 2011

Information technology is generally considered an enabler of a firm's agility. A typical premise is that greater IT investment enables a firm to be more agile. However, it is not uncommon that IT can also hinder and sometimes even impede organizational agility. We propose and theorize this frequently observed but understudied IT-agility contradiction by which IT may enable or impede agility. We develop the premise that organizations need to develop superior firm-wide IT capability to successfully manage their IT resources to realize agility. We refine the conceptualization and measurement of IT capability as a latent construct reflected in its three dimensions: IT infrastructure capability, IT business spanning capability, and IT proactive stance. We also conceptualize two types of organizational agility: market capitalizing agility and operational adjustment agility. We then conduct a matched-pair field survey of business and information systems executives in 128 organizations to empirically examine the link between a firm's IT capability and agility. Business executives responded to measurement scales of the two types of agility and organizational context variables, and IS executives responded to measurement scales of IT capabilities and IS context variables. The results show a significant positive relationship between IT capability and the two types of organizational agility. We also find a significant positive joint effect of IT capability and IT spending on operational adjustment agility but not on market capitalizing agility. The findings suggest a possible resolution to the contradictory effect of IT on agility: while more IT spending does not lead to greater agility, spending it in such a way as to enhance and foster IT capabilities does. Our study provides initial empirical evidence to better understand essential IT capabilities and their relationship with organizational agility. Our findings provide a number of useful implications for research and managerial practices. Source

Proctor R.A.,University of Wisconsin - Milwaukee
Vaccine | Year: 2012

Multiple attempts to develop a vaccine to prevent Staphylococcus aureus infections have failed. To date, all have been based upon the development of opsonic antibodies. New information suggests that cell mediated immunity may be critical for protection against S. aureus infections. The arm of the immune system that provides the protection contains the Th17/IL-17 axis. Th17 cells release IL-17, which are important for mobilization and activation of neutrophils. Naturally, antibodies aid the neutrophils in the uptake and killing of staphylococci, but immune globulin does not seem to be sufficient to afford protection. New approaches that focus on Th17/IL-17 may allow for the development of a successful S. aureus vaccine. © 2011 Elsevier Ltd. Source

Ellis J.A.,University of Wisconsin - Milwaukee
Classical and Quantum Gravity | Year: 2013

The direct detection of gravitational waves (GWs) by pulsar timing arrays (PTAs) is very likely within the next decade. While the stochastic GW background is a promising candidate for detection it is also possible that single resolvable sources may be detectable as well. In this work we will focus on the detection and characterization of single GW sources from supermassive black hole binaries. We introduce a fully Bayesian data analysis pipeline that is meant to carry out a search, characterization, and evaluation phase. This will allow us to rapidly locate the global maxima in parameter space, map out the posterior, and finally weigh the evidence of a GW detection through a Bayes factor. Here we will make use of an adaptive metropolis algorithm and parallel tempering. We test this algorithm on realistic simulated data that are representative of modern PTAs. © 2013 IOP Publishing Ltd. Source

Frick K.M.,University of Wisconsin - Milwaukee
Hormones and Behavior | Year: 2015

This article is part of a Special Issue "Estradiol and cognition".Since the publication of the 1998 special issue of Hormones and Behavior on estrogens and cognition, substantial progress has been made towards understanding the molecular mechanisms through which 17β-estradiol (E2) regulates hippocampal plasticity and memory. Recent research has demonstrated that rapid effects of E2 on hippocampal cell signaling, epigenetic processes, and local protein synthesis are necessary for E2 to facilitate the consolidation of object recognition and spatial memories in ovariectomized female rodents. These effects appear to be mediated by non-classical actions of the intracellular estrogen receptors ERα and ERβ, and possibly by membrane-bound ERs such as the G-protein-coupled estrogen receptor (GPER). New findings also suggest a key role of hippocampally-synthesized E2 in regulating hippocampal memory formation. The present review discusses these findings in detail and suggests avenues for future study. © 2015 Elsevier Inc. Source

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