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The University of Western Ontario , which is commonly referred to among Canadian universities as Western or Western University, is a public research university located in London, Ontario, Canada. The university was founded on 7 March 1878 by Bishop Isaac Hellmuth of the Anglican Diocese of Huron as "The Western University of London Ontario." It incorporated Huron University College, which had been founded in 1863. The first four faculties were Arts, Divinity, Law and Medicine. The Western University of London was eventually made non-denominational in 1908.According to the 2012 Academic Ranking of World Universities rankings, the university ranked 201–300 in the world and top 10 in Canada. The 2011 QS World University Rankings ranked the university 157th in the world, making it seventh in Canada. Several of Western's programs were also ranked in individual rankings. Social science at Western was ranked 96th in the world in the 2010 QS World University Rankings, and Western's Ivey Business School was ranked 1st in the World in the Global MBA Category of Bloomberg Businessweek.Western's Co-educational Student body of over 24,000 represents 107 countries around the world and Western scholars have established research and education collaborations and partnerships on every continent. There are more than 306,000 alumni who are active internationally, living and working around the globe. Notable alumni include government officials, academics, business leaders, Nobel Laureates, Rhodes Scholars, and distinguished fellows.Western's varsity teams, known as the Western Mustangs, compete in the Ontario University Athletics conference of the Canadian Interuniversity Sport. Wikipedia.

Laird D.W.,University of Western Ontario
Trends in Cell Biology

In recent years our understanding of connexins has advanced from viewing them simply as proteins with a surprisingly short lifespan that form gap junction channels. Connexins are now known to be multifaceted proteins at the core of many multiprotein complexes that link to structural junctional complexes and cytoskeletal elements, and also to the cellular machinery that facilitates their transport, assembly, function and internalization. Collectively, these connexin-binding proteins can be termed the 'gap junction proteome'. The mechanistic understanding of the gap junction proteome with regards to the dynamic life cycle of connexins has grown further in importance in light of the large number of human diseases attributed to connexin gene mutations and regulatory changes in connexin spatial localization and expression levels. © 2009 Elsevier Ltd. All rights reserved. Source

Dick F.A.,University of Western Ontario | Rubin S.M.,University of California at Santa Cruz
Nature Reviews Molecular Cell Biology

Inactivation of the RB protein is one of the most fundamental events in cancer. Coming to a molecular understanding of its function in normal cells and how it impedes cancer development has been challenging. Historically, the ability of RB to regulate the cell cycle placed it in a central role in proliferative control, and research focused on RB regulation of the E2F family of transcription factors. Remarkably, several recent studies have found additional tumour-suppressor functions of RB, including alternative roles in the cell cycle, maintenance of genome stability and apoptosis. These advances and new structural studies are combining to define the multifunctionality of RB. © 2013 Macmillan Publishers Limited. All rights reserved. Source

Leask A.,University of Western Ontario
Circulation Research

Fibrotic diseases are a significant global burden for which there are limited treatment options. The effector cells of fibrosis are activated fibroblasts called myofibroblasts, a highly contractile cell type characterized by the appearance of α-smooth muscle actin stress fibers. The underlying mechanism behind myofibroblast differentiation and persistence has been under much investigation and is known to involve a complex signaling network involving transforming growth factor-β, endothelin-1, angiotensin II, CCN2 (connective tissue growth factor), and platelet-derived growth factor. This review addresses the contribution of these signaling molecules to cardiac fibrosis. © 2015 American Heart Association, Inc. Source

University of Western Ontario | Date: 2014-09-30

Systems and methods relating to a clutch system for use in controllably transmitting torque from an input shaft to an output shaft. The clutch system has a torque transmission fluid that has a viscosity that changes based on the strength of an electromagnetic field passing through the fluid. A number of sensors are placed at different radial locations on the torque transmission disks to detect the strength of the electromagnetic field. Based on the strength of the electromagnetic field, the amount of torque being transmitted from the input shaft to the output shaft can be adjusted. Also disclosed is a distributed actuation architecture that uses this clutch system. The distributed actuation architecture allows for the use of a single drive motor in conjunction with multiple instances of the clutch system to actuate a mechanical linkage, such as a robotic arm.

Systems, methods, and devices relating to a mechanism which can be used in gas cooling devices, pneumatic motors, turbines and other pressurized gas devices. A rotatable rotor is provided along with a number of hollow conduits that radially radiate from an exit port at the center of the rotor. The pressurized gas is injected into the mechanism at the inlet port(s). The gas enters the conduits and travels from the inlet port(s) to the exit port(s). In doing so, the gas causes the rotor to rotate about its central axis while the gas cools. This results in a colder gas at the exit port(s) than at the inlet port(s) due to an enhanced extraction of work, while maintaining a very low flow rate at the cold outlet.

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