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The University of Western Australia is a research-intensive university in Perth, Australia that was established by an act of the Western Australian Parliament in February 1911, and began teaching students for the first time in 1913. It is the oldest university in the state of Western Australia and is colloquially known as a "sandstone university". It is also a member of the Group of Eight.UWA was established under and is governed by the University of Western Australia Act 1911. The Act provides for control and management by the university's Senate, and gives it the authority, amongst other things, to make statutes, regulations and by-laws, details of which are contained in the university Calendar.UWA is highly ranked internationally in various publications: the 2013/14 QS World University Rankings placed UWA at 84th internationally, and in August 2014 the The Academic Ranking of World Universities from Shanghai Jiao Tong University placed the university at 88th in the world. To date, the university has produced 100 Rhodes Scholars, 1 Nobel Prize laureate and 1 Australian Prime Minister graduated from UWA.UWA recently joined the Matariki Network of Universities as the youngest member, the only one established during the 20th century. Wikipedia.

Jablensky A.,University of Western Australia
World Psychiatry | Year: 2016

Despite historical assumptions to the contrary, there is little evidence that the majority of recognized mental disorders are separated by natural boundaries. Diagnostic categories defined by their clinical syndromes should be regarded as 'valid' only if they have been shown to be truly discrete entities. Most diagnostic concepts in psychiatry have not been demonstrated to be valid in this sense, though many possess 'utility' by virtue of the information they convey about presenting symptoms, outcome, treatment response and, in some instances, aetiology. While researchers in genetics, neurobiology and population epidemiology are increasingly more likely to adopt a continuum/dimensional view of the variation in symptomatology, clinicians prefer to hold on to the categorical approach embodied in current classifications such as ICD-10 and DSM-5. Both points of view have plausible justification in their respective contexts, but the way forward may be in their conceptual reconciliation.

Barkan A.,University of Oregon | Small I.,University of Western Australia
Annual Review of Plant Biology | Year: 2014

Pentatricopeptide repeat (PPR) proteins constitute one of the largest protein families in land plants, with more than 400 members in most species. Over the past decade, much has been learned about the molecular functions of these proteins, where they act in the cell, and what physiological roles they play during plant growth and development. A typical PPR protein is targeted to mitochondria or chloroplasts, binds one or several organellar transcripts, and influences their expression by altering RNA sequence, turnover, processing, or translation. Their combined action has profound effects on organelle biogenesis and function and, consequently, on photosynthesis, respiration, plant development, and environmental responses. Recent breakthroughs in understanding how PPR proteins recognize RNA sequences through modular base-specific contacts will help match proteins to potential binding sites and provide a pathway toward designing synthetic RNA-binding proteins aimed at desired targets. Copyright © 2014 by Annual Reviews.

Thomas M.L.,University of Western Australia
Biological Reviews | Year: 2011

Males of many species choose their mate according to the female's reproductive status, and there is now increasing evidence that male fitness can depend on this discrimination. However, females will also aim to regulate their mating activity so as to maximize their own fitness. As such, both sexes may attempt to dictate the frequency and timing of female mating, reflecting the potentially different costs of female signaling to both sexes. Here, I review evidence that chemical cues and signals are used widely by males to discriminate between mated and unmated females, and explore the mechanisms by which female odour changes post-mating. There is substantial empirical evidence that mated and unmated females differ in their chemical profile, and that this variation provides males with information on a female's mating status. Although there appears to be large variation among species regarding the mechanisms by which female odour is altered post-mating, the transfer of male substances to females during or subsequent to copulation appear to play a major role. This transfer of substances by males may be part of their strategy to suppress reproduction by competing males, particularly in species where females mate more than once. © 2010 The Author. Biological Reviews © 2010 Cambridge Philosophical Society.

Corry B.,University of Western Australia
Energy and Environmental Science | Year: 2011

The use of semipermeable membranes containing carbon nanotubes (CNTs) that form continuous pores has been suggested as a way to reduce the cost of desalination via reverse osmosis. Example membranes containing aligned CNTs have been fabricated, but obtaining only the very narrow pores that are able to block the passage of ions while allowing a rapid flow of water remains a challenge and previous computational studies have focused on idealised tubes. Here molecular dynamics simulations are used to examine water and ion transport through functionalised CNTs with the aim of investigating whether such chemical modification allows the performance of CNT based membranes to be improved, or for larger diameter pores to be used. A range of different charged and polar functional groups were added to a 1.1 nm diameter (8,8) CNT that was previously found to be only moderately effective at rejecting ions. These CNTs were incorporated into membranes and simulations were conducted with a hydrostatic pressure difference to determine the ion rejection and flux of water passing through each as well as the energy barriers presented to ions and water molecules. The results show that the addition of charges at the entrance of the pore can help to prevent the passage of ions, however, any functionalisation also reduces the flow of water through the membrane due to increased electrostatic interactions between the water molecules and the CNT. Assuming pore densities that have previously been achieved, the performance of these membranes in the simulations is still many times better than existing technology and thus the inclusion of functionalised CNTs in desalination membranes may prove to be useful in achieving salt rejection and rapid water flow. © 2011 The Royal Society of Chemistry.

Hankey G.J.,University of Western Australia
The Lancet Neurology | Year: 2014

Survivors of stroke and transient ischaemic attacks are at risk of a recurrent stroke, which is often more severe and disabling than the index event. Optimum secondary prevention of recurrent stroke needs rapid diagnosis and treatment and prompt identification of the underlying cardiovascular cause. Effective treatments include organised acute assessment and intervention with antithrombotic therapy, carotid revascularisation, and control of causal risk factors, as appropriate. However, effective treatments are not implemented optimally in clinical practice. Recurrent strokes continue to account for 25-30% of all strokes and represent unsuccessful secondary prevention. Immediate and sustained implementation of effective and appropriate secondary prevention strategies in patients with first-ever stroke or transient ischaemic attack has the potential to reduce the burden of stroke by up to a quarter. © 2014 Elsevier Ltd.

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