Perth, Australia

The University of Western Australia is a research-intensive university in Perth, Australia that was established by an act of the Western Australian Parliament in February 1911, and began teaching students for the first time in 1913. It is the oldest university in the state of Western Australia and is colloquially known as a "sandstone university". It is also a member of the Group of Eight.UWA was established under and is governed by the University of Western Australia Act 1911. The Act provides for control and management by the university's Senate, and gives it the authority, amongst other things, to make statutes, regulations and by-laws, details of which are contained in the university Calendar.UWA is highly ranked internationally in various publications: the 2013/14 QS World University Rankings placed UWA at 84th internationally, and in August 2014 the The Academic Ranking of World Universities from Shanghai Jiao Tong University placed the university at 88th in the world. To date, the university has produced 100 Rhodes Scholars, 1 Nobel Prize laureate and 1 Australian Prime Minister graduated from UWA.UWA recently joined the Matariki Network of Universities as the youngest member, the only one established during the 20th century. Wikipedia.


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Patent
University of Western Australia | Date: 2014-09-12

An antisense oligonucleotide of 10 to 50 nucleotides comprising a targeting sequence complementary to a region near or within intron 6, intron 7, or exon 8 of the Survival Motor Neuron 2 (SMN2) gene pre-mRNA.


Patent
Proteomics International Pty Ltd and University of Western Australia | Date: 2017-04-05

The invention provides biomarkers for pre-Diabetes, Diabetes and/or a Diabetes related conditions, and methods of their use, including the biomarkers in Tables 1 and 2 such as peroxiredoxin-2, complement Clq subcomponent subunit B, sulfhydryl oxidase 1 and apolipoprotein A-IV.


Further High Grade Gold-Copper Mineralisation Reported from Infill and Extension Drilling at the Hot Maden Project, NE Turkey. Mariana Resources Limited ('Mariana' or 'the Company'), the TSX.V and AIM (MARL) listed exploration and development company with projects in Turkey, South America, and Ivory Coast, is pleased to provide the following update on the ongoing diamond drill program at the high grade Hot Maden gold-copper project in NE Turkey. Assay results are reported for a total of 8 new drill holes (HTD-109, HTD-110, HTD-112, HTD-114 to HTD-117, and HTD-119), with a further 5 holes (HTD-107, HTD-108, HTD-111, HTD-113, and HTD-118) currently undergoing detailed geotechnical logging and with sampling/assaying still pending. Of the eight holes for which assays have been received, six were completed in the Main Zone resource area and the Southern Deposit; Figures 1 & 2); the remaining two holes (HTD-115 and HTD-119) represent the first scout holes to be completed in the Pre-1923 Russian Mining Area (Figure 3). An update on both the permitting of new drill holes and final results from the Phase I drill program at the Company's 100%-owned Ergama gold-copper project in western Turkey is also provided. Main Zone - Section 4,542,175N HTD-109:             75m @ 17.2 g/t Au + 1.89% Cu from 212m downhole. (Step forward    Including 13.7m @ 49.5 g/t Au + 2.95% Cu from 214.3m downhole, To HTD-106)       And 10m @ 39.9 g/t Au + 1.68% Cu from 237m downhole. (approximate true width of Au-Cu zone is 55m) HTD-110:             59m @ 18.2 g/t Au + 2.31% Cu from 190m downhole. (Step forward    Including 13m @ 50.2 g/t Au + 2.79% Cu from 190m downhole. to HTD-109)        (approximate true width of Au-Cu zone is 45m) HTD-116:             78m @ 5.2 g/t Au 3.76% Cu from 33m downhole. (Step forward    Including 9m @ 21.9 g/t Au + 6.49% Cu from 46m downhole. to HTD-110)        (approximate true width of Au-Cu zone is 60m) The Pre-1923 Russian Mine Area is a complex zone of mineralised veins and hydrothermal alteration, with these initial results being similar to those obtained from the first drill holes around the Main Zone discovery. As drill holes HTD-115 and HTD-119 were both collared 300m vertically above the uppermost known elevation of the Main Zone mineralisation, the possibilility that the narrow veins/veinlets intersected form part of a distal stringer zone to a buried massive sulfide system will be tested through future dilling. "Mariana's focused exploration and development work continues and today we announce further positive results from ongoing and increased drilling at Hot Maden, as well as the update on the Ergama project. "At Hot Maden, in the Main Zone, continued success from infill and step out drilling compliment our current results whilst maintaining our confidence in this zone. "In the Southern Zone these new results extend mineralisation and the strike length from the Main Zone to the Southern Zone which is continuing to grow. "Encouragingly, the 3rd operational rig in the Old Russian Mining Area has intersected narrow high grade gold and copper with higher grade zinc.  This is a complex part of the new untested system and these early positive results are assisting in the understanding of the mineralisation potential of this previously mined area. "At Ergama, in western Turkey, Mariana is awaiting permitting on 24 new holes in order to target, the hopefully better mineralised, potassic zone of the porphyry system to the south of the current 5 hole completed program. "Mariana continues to deliver exciting exploration results and I look forward to updating the market accordingly." Approximately 38,000 m of diamond drilling have now been completed by the Mariana-Lidya JV at Hot Maden since November, 2014 (Figures 1 - 3).  Recent drilling activities have focused on: - The planned infill drill program in the Main Zone resource area advanced with a further three holes (HTD-109, HTD-110, and HTD-106) being completed on section 4,542,175N. This program continues to be highly successful in confirming the internal continuity of the high-grade gold-copper mineralisation within the Main Zone. One step forward hole (HTD-114) was also completed on section 4,542,150N, with this hole intersecting gold-zinc mineralization along the margins of the Main Zone. On cross-section 4,542,175N (Figures 2 and 4), infill drill holes HTD-109 and HTD-110 returned 75m @ 17.2 g/t Au + 1.89% Cu from 212m downhole and 59m @ 18.2 g/t Au + 2.31% Cu from 190m downhole, respective. Both mineralised intervals are hosted within a multiphase, chalcopyrite-pyrite-hematite-jasper-bearing breccia, with a prominent "ultra high grade" gold zone once again being developed close to the eastern margin of the broader mineralised zone. Drill hole HTD-116 tested the near-surface portion of the Main Zone on section 4,542,175N and intersected both multiphase breccia and (faulted) massive sulfide type copper-gold mineralisation. Assays were received for two drill holes (HTD-112 and HTD-117) in the Southern Deposit, with the best results being reported from step back drill hole HTD-117 (7m @ 16.5 g/t Au + 0.30% Cu from 233m downhole, 2m @ 24.4 g/t Au + 0.94% Cu from 143m downhole, and 4m @ 7.2 g/t Au + 0.50% Cu from 181m downhole; section 4,541,900N). Encouraging intercepts were also returned from drill hole HTD-112, which was designed to extend known mineralisation in the Southern Deposit to the south, including 1m @ 7.4 g/t Au + 1.21% Cu from 58m downhole, 1m @ 29 g/t Au + 0.26% Cu from 62m downhole, and 4m @ 6.7 g/t Au + 0.35% Cu from 107m downhole, together with 22m @ 5.1% Zn from 292m downhole. Initial scout drilling has commenced in the Pre-1923 Russian Mining Area, in an area located approximately 1km to the south of the Southern Deposit. Two holes have been completed to date (HTD-115 and HTD-119), with HTD-115 intersecting narrow quartz vein gold-copper mineralisation and HTD-119 the interpreted hanging wall zinc zone. Key results include: The Pre-1923 Russian Mine Area is a complex zone of mineralised veins and hydrothermal alteration, with these initial results being similar to those obtained from the first drill holes around the Main Zone discovery. Further work will be required to identify the central part of the mineralized system. Table 1: Summary of assays for drill holes HTD-107 to HTD-119 (see also Figures 1 to 4 for drill hole locations and key cross sections). Mineralised intervals presented in Table 1 are drill intersection widths and may not represent true widths of mineralisation. Drill core obtained from the diamond drill program was dominantly HQ-sized core with the remainder being PQ-sized core. All drill core was photographed and quick logged prior to sampling. Standard sampling protocol involved the halving of all drill core and sampling over generally 1 m intervals (in clearly mineralised sections) or 2 m intervals (elsewhere), with one half of the core being placed in a sealed sample bag and dispatched to the analytical laboratory for analysis. Samples have been analysed at ALS Laboratories' facility in Izmir, western Turkey. All samples have been analysed for gold using a 30g Fire Assay with AAS finish (or Screen Fire Assay for higher grade samples), in addition to a 32 element ICP-AES analysis of an aqua regia digest.  Samples in which ICP analyses returned greater than the maximum detection limit for the elements Ag (10 ppm), Cu (10,000 ppm), Fe (15%), Pb (10,000 ppm), and Zn (10,000 ppm) were reanalysed using the AAS analytical technique, Standards and blanks were inserted in to the analytical sequence on the basis of one standard for every 20 samples, 2 blanks in every batch, and one duplicate every 40 samples. No HSE incidents have been reported during the current diamond drill program. Technical data relating to Hot Maden diamond drill holes HTD-107 to HTD-119 are given in the following table. Ergama Project Update Applications were presented in February 2017 for the approval of 24 potential new drill platforms located to the south of drill holes ERD-01 / ERD-02. Both ERD-01 and ERD-02 successfully intersected significant intervals of gold-bearing, porphyry-style quartz (-pyrite +/- chalcopyrite) stockwork mineralisation, with assay data confirming an overall increase in Au-Cu grades towards the south (see Mariana News Release dated February 14, 2017). Host rock alteration assemblages in ERD-01/ERD-02 are dominantly phyllic and also suggest that these drill holes may be distal to the potassic-altered (and potentially better mineralised) core of the porphyry system. Approval of these new drill platforms is expected shortly, with planning for the Phase II drill program now currently underway. A total of 5 diamond drill holes (for 2,225.8m of drilling, as per approved budget) were completed in the Phase I drill program; a further two planned holes were postponed until the approval of the new drill permits. Results obtained from the final three holes (ERD-03 to ERD-05) are summarized below. ERD-03 was collared on the NW margin of the main IP anomaly (and 250m W of drill holes ERD-01/-02), and intersected argillic altered volcanic and subvolcanic rocks (with locally minor phyllic alteration and quartz-pyrite stockworks). Intensely silicified carbonate rocks were also intersected near the end of the hole and these may represent rafts of material from the basement sequence. The best mineralised sections of ERD-03 are of similar tenor to those in ERD-01/-02, and include: 14m @ 0.24 g/t Au from 72m, 24m @ 0.22 g/t Au + 0.1% Cu from 156m, 2m @ 0.82 g/t Au from 252m, 4m @ 0.32 g/t Au from 264m, and 32m @ 0.27 g/t Au from 284m. ERD-04 was collared on a high grade vein / fault target (with surface assays up to 16 g/t Au) and is located approximately 950m to the NE of ERD-01/-02. ERD-04 was designed to cut the interpreted controlling structure around 40m vertically below surface, and intersected intense faulting from the collar to around 56m downhole. No core was recovered from 45.1m to 49.2m downhole - suggesting either a possible void or milled zone - and was followed by 1.1m @ 1.4 g/t Au + 10 g/t Ag from 49.2m and 2m @ 4.6 g/t Au (silicified breccia) from 56m. A step back hole to ERD-04, designed to intersect this epithermal style mineralized zone at a deeper level, is expected to be incorporated in to the Ergama Phase II drill program. ERD-05 was collared on a satellite IP chargeability anomaly located approximately 1km ENE of drill holes ERD-01/-02. ERD-05 intersected approximately 150m of argillic altered andesites (from 180m downhole) with average gold grades of <0.15 g/t Au and a best intercept of 12m @ 0.19 g/t Au from 330m downhole. Accordingly, this sector represents a low priority target for follow-up work. Technical data relating to Ergama diamond drill holes ERD-01 to ERD-05 are given in the following table. **ENDS** Qualified Person                                                                                                                         The technical and scientific information contained in this news release has been reviewed and approved for release by Eric Roth, the Company's Qualified Person as defined by National Instrument 43-101. Mr Roth is the Company's Chief Operating Officer and Executive Director and holds a Ph.D. in Economic Geology from the University of Western Australia, is a Fellow of the Australian Institute of Mining and Metallurgy (AusIMM), and is a Fellow of the Society of Economic Geologists (SEG).  Mr Roth has 25 years of experience in international minerals exploration and mining project evaluation. About Mariana Resources Mariana Resources Ltd is a TSX.V and AIM (MARL) quoted exploration and development company with an extensive portfolio of gold, silver, and copper projects in South America, Turkey, and Ivory Coast. Mariana's most advanced asset is the Hot Maden gold-copper project in northeast Turkey, which is a joint venture with Turkish partner Lidya Madencilik (30% Mariana and 70% Lidya) and which is rapidly advancing to development.  On January 17, 2017, Mariana released the results of a Preliminary Economic Study ("PEA") which demonstrated exceptional potential economics for the Hot Maden Project (after-tax NPV and IRR of USD 1.37B and 153%, respectively) based on a development scenario incorporating a 1Mtpa underground mining / processing operation and the production of two saleable concentrates (a copper-gold concentrate and a gold-pyrite concentrate). This PEA was based on the updated (July 25, 2016) mineral resource estimate of 3.43 Moz gold equivalent (Indicated Category) and 0.09 Moz gold equivalent (Inferred Category) (100% basis) in the Main Zone, as well as a maiden 351,000 Moz gold equivalent (Inferred Category) (100% basis) resource in the New Southern Discovery. Elsewhere in Turkey, Mariana holds a 100% interest in the Ergama project where first drilling was reported on February 14, 2017, to have intersected porphyry-style gold-copper mineralisation. On October 7, 2016, Mariana announced the signing of a binding Term Sheet to acquire an indirect 80% interest in Ivory Coast-focused private exploration company Awalé Resources SARL ("Awalé").  Through the transaction Mariana will gain an immediate foothold in an established exploration portfolio with known gold mineralisation and artisanal gold workings, and which comprises i) 3 granted contiguous licenses (1,191 km2) in the Bondoukou area, and ii) 4 licenses under application (1,593 km2) in both the Bondoukou and Abengourou areas. The Boundoukou concessions lie along the southwestern extension of the Birimian Bole-Nangodi greenstone belt in adjacent Ghana, host to a number of high grade orogenic gold deposits. In southern Argentina, the Company's core gold-silver projects are Las Calandrias (100%), Sierra Blanca (100%), Los Cisnes (100%), and Bozal (100%). These projects are part of a 100,000+ Ha land package in the Deseado Massif epithermal gold-silver district in mining-friendly Santa Cruz Province. In Suriname, Mariana has a direct holding of 10.2% of the Nassau Gold project. The Nassau Gold Project is a 28,000 Ha exploration concession located approximately 125 km south east of the capital Paramaribo and immediately adjacent to Newmont Mining's 4.2Moz gold Merian project. *Au Equivalence (AuEq) calculated using a 100 day moving average of $US1,215/ounce for Au and $US2.13/pound for Cu as of May 29, 2016. No adjustment has been made for metallurgical recovery or net smelter return as these remain uncertain at this time. Based on grades and contained metal for Au and Cu, it is assumed that both commodities have reasonable potential to be economically extractable. Safe Harbour This press release contains certain statements which may be deemed to be forward-looking statements.  These forward-looking statements are made as at the date of this press release and include, without limitation, statements regarding discussions of future plans, the realization, cost, timing and extent of mineral resource estimates, estimated future exploration expenditures, costs and timing of the development of new deposits, success of exploration activities, permitting time lines, and requirements for additional capital.  The words "plans", "expects", "budget", "scheduled", "estimate", "forecasts", "intend", "anticipate", "believe", "may", "will", or similar expressions or variations of such words are intended to identify forward-looking statements.  Forward-looking statements are subject to known and unknown risks, uncertainties, assumptions and other factors that may cause actual results to vary materially from those expressed or implied by such forward-looking statements, including, but not limited to: the effects of general economic conditions; the price of gold, silver and copper; misjudgements in the course of preparing forward-looking statements; risks associated with international operations; the need for additional financing; risks inherent in exploration results; conclusions of economic evaluations; changes in project parameters; currency and commodity price fluctuations; title matters; environmental liability claims; unanticipated operational risks; accidents, labour disputes and other risks of the mining industry; delays in obtaining governmental approvals or in the completion of development or construction activities; political risk; and other risks and uncertainties described in the Company's annual financial statements for the most recently completed financial year which is available on the Company's website at www.marianaresources.com .  Although we believe that the expectations reflected in such forward-looking statements are based upon reasonable assumptions and have attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking statements, there may be other factors that cause results not to be as anticipated, estimated or intended.  There can be no assurance that such statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such forward-looking statements.  Accordingly, readers are cautioned not to place undue reliance on forward-looking statements.  We do not undertake to update any forward-looking statements, except in accordance with applicable securities laws. Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.


Further High Grade Gold-Copper Mineralisation Reported from Infill and Extension Drilling at the Hot Maden Project, NE Turkey. Mariana Resources Limited ('Mariana' or 'the Company'), the TSX.V and AIM (MARL) listed exploration and development company with projects in Turkey, South America, and Ivory Coast, is pleased to provide the following update on the ongoing diamond drill program at the high grade Hot Maden gold-copper project in NE Turkey. Assay results are reported for a total of 8 new drill holes (HTD-109, HTD-110, HTD-112, HTD-114 to HTD-117, and HTD-119), with a further 5 holes (HTD-107, HTD-108, HTD-111, HTD-113, and HTD-118) currently undergoing detailed geotechnical logging and with sampling/assaying still pending. Of the eight holes for which assays have been received, six were completed in the Main Zone resource area and the Southern Deposit; Figures 1 & 2); the remaining two holes (HTD-115 and HTD-119) represent the first scout holes to be completed in the Pre-1923 Russian Mining Area (Figure 3). An update on both the permitting of new drill holes and final results from the Phase I drill program at the Company's 100%-owned Ergama gold-copper project in western Turkey is also provided. Main Zone - Section 4,542,175N HTD-109:             75m @ 17.2 g/t Au + 1.89% Cu from 212m downhole. (Step forward    Including 13.7m @ 49.5 g/t Au + 2.95% Cu from 214.3m downhole, To HTD-106)       And 10m @ 39.9 g/t Au + 1.68% Cu from 237m downhole. (approximate true width of Au-Cu zone is 55m) HTD-110:             59m @ 18.2 g/t Au + 2.31% Cu from 190m downhole. (Step forward    Including 13m @ 50.2 g/t Au + 2.79% Cu from 190m downhole. to HTD-109)        (approximate true width of Au-Cu zone is 45m) HTD-116:             78m @ 5.2 g/t Au 3.76% Cu from 33m downhole. (Step forward    Including 9m @ 21.9 g/t Au + 6.49% Cu from 46m downhole. to HTD-110)        (approximate true width of Au-Cu zone is 60m) The Pre-1923 Russian Mine Area is a complex zone of mineralised veins and hydrothermal alteration, with these initial results being similar to those obtained from the first drill holes around the Main Zone discovery. As drill holes HTD-115 and HTD-119 were both collared 300m vertically above the uppermost known elevation of the Main Zone mineralisation, the possibilility that the narrow veins/veinlets intersected form part of a distal stringer zone to a buried massive sulfide system will be tested through future dilling. "Mariana's focused exploration and development work continues and today we announce further positive results from ongoing and increased drilling at Hot Maden, as well as the update on the Ergama project. "At Hot Maden, in the Main Zone, continued success from infill and step out drilling compliment our current results whilst maintaining our confidence in this zone. "In the Southern Zone these new results extend mineralisation and the strike length from the Main Zone to the Southern Zone which is continuing to grow. "Encouragingly, the 3rd operational rig in the Old Russian Mining Area has intersected narrow high grade gold and copper with higher grade zinc.  This is a complex part of the new untested system and these early positive results are assisting in the understanding of the mineralisation potential of this previously mined area. "At Ergama, in western Turkey, Mariana is awaiting permitting on 24 new holes in order to target, the hopefully better mineralised, potassic zone of the porphyry system to the south of the current 5 hole completed program. "Mariana continues to deliver exciting exploration results and I look forward to updating the market accordingly." Approximately 38,000 m of diamond drilling have now been completed by the Mariana-Lidya JV at Hot Maden since November, 2014 (Figures 1 - 3).  Recent drilling activities have focused on: - The planned infill drill program in the Main Zone resource area advanced with a further three holes (HTD-109, HTD-110, and HTD-106) being completed on section 4,542,175N. This program continues to be highly successful in confirming the internal continuity of the high-grade gold-copper mineralisation within the Main Zone. One step forward hole (HTD-114) was also completed on section 4,542,150N, with this hole intersecting gold-zinc mineralization along the margins of the Main Zone. On cross-section 4,542,175N (Figures 2 and 4), infill drill holes HTD-109 and HTD-110 returned 75m @ 17.2 g/t Au + 1.89% Cu from 212m downhole and 59m @ 18.2 g/t Au + 2.31% Cu from 190m downhole, respective. Both mineralised intervals are hosted within a multiphase, chalcopyrite-pyrite-hematite-jasper-bearing breccia, with a prominent "ultra high grade" gold zone once again being developed close to the eastern margin of the broader mineralised zone. Drill hole HTD-116 tested the near-surface portion of the Main Zone on section 4,542,175N and intersected both multiphase breccia and (faulted) massive sulfide type copper-gold mineralisation. Assays were received for two drill holes (HTD-112 and HTD-117) in the Southern Deposit, with the best results being reported from step back drill hole HTD-117 (7m @ 16.5 g/t Au + 0.30% Cu from 233m downhole, 2m @ 24.4 g/t Au + 0.94% Cu from 143m downhole, and 4m @ 7.2 g/t Au + 0.50% Cu from 181m downhole; section 4,541,900N). Encouraging intercepts were also returned from drill hole HTD-112, which was designed to extend known mineralisation in the Southern Deposit to the south, including 1m @ 7.4 g/t Au + 1.21% Cu from 58m downhole, 1m @ 29 g/t Au + 0.26% Cu from 62m downhole, and 4m @ 6.7 g/t Au + 0.35% Cu from 107m downhole, together with 22m @ 5.1% Zn from 292m downhole. Initial scout drilling has commenced in the Pre-1923 Russian Mining Area, in an area located approximately 1km to the south of the Southern Deposit. Two holes have been completed to date (HTD-115 and HTD-119), with HTD-115 intersecting narrow quartz vein gold-copper mineralisation and HTD-119 the interpreted hanging wall zinc zone. Key results include: The Pre-1923 Russian Mine Area is a complex zone of mineralised veins and hydrothermal alteration, with these initial results being similar to those obtained from the first drill holes around the Main Zone discovery. Further work will be required to identify the central part of the mineralized system. Table 1: Summary of assays for drill holes HTD-107 to HTD-119 (see also Figures 1 to 4 for drill hole locations and key cross sections). Mineralised intervals presented in Table 1 are drill intersection widths and may not represent true widths of mineralisation. Drill core obtained from the diamond drill program was dominantly HQ-sized core with the remainder being PQ-sized core. All drill core was photographed and quick logged prior to sampling. Standard sampling protocol involved the halving of all drill core and sampling over generally 1 m intervals (in clearly mineralised sections) or 2 m intervals (elsewhere), with one half of the core being placed in a sealed sample bag and dispatched to the analytical laboratory for analysis. Samples have been analysed at ALS Laboratories' facility in Izmir, western Turkey. All samples have been analysed for gold using a 30g Fire Assay with AAS finish (or Screen Fire Assay for higher grade samples), in addition to a 32 element ICP-AES analysis of an aqua regia digest.  Samples in which ICP analyses returned greater than the maximum detection limit for the elements Ag (10 ppm), Cu (10,000 ppm), Fe (15%), Pb (10,000 ppm), and Zn (10,000 ppm) were reanalysed using the AAS analytical technique, Standards and blanks were inserted in to the analytical sequence on the basis of one standard for every 20 samples, 2 blanks in every batch, and one duplicate every 40 samples. No HSE incidents have been reported during the current diamond drill program. Technical data relating to Hot Maden diamond drill holes HTD-107 to HTD-119 are given in the following table. Ergama Project Update Applications were presented in February 2017 for the approval of 24 potential new drill platforms located to the south of drill holes ERD-01 / ERD-02. Both ERD-01 and ERD-02 successfully intersected significant intervals of gold-bearing, porphyry-style quartz (-pyrite +/- chalcopyrite) stockwork mineralisation, with assay data confirming an overall increase in Au-Cu grades towards the south (see Mariana News Release dated February 14, 2017). Host rock alteration assemblages in ERD-01/ERD-02 are dominantly phyllic and also suggest that these drill holes may be distal to the potassic-altered (and potentially better mineralised) core of the porphyry system. Approval of these new drill platforms is expected shortly, with planning for the Phase II drill program now currently underway. A total of 5 diamond drill holes (for 2,225.8m of drilling, as per approved budget) were completed in the Phase I drill program; a further two planned holes were postponed until the approval of the new drill permits. Results obtained from the final three holes (ERD-03 to ERD-05) are summarized below. ERD-03 was collared on the NW margin of the main IP anomaly (and 250m W of drill holes ERD-01/-02), and intersected argillic altered volcanic and subvolcanic rocks (with locally minor phyllic alteration and quartz-pyrite stockworks). Intensely silicified carbonate rocks were also intersected near the end of the hole and these may represent rafts of material from the basement sequence. The best mineralised sections of ERD-03 are of similar tenor to those in ERD-01/-02, and include: 14m @ 0.24 g/t Au from 72m, 24m @ 0.22 g/t Au + 0.1% Cu from 156m, 2m @ 0.82 g/t Au from 252m, 4m @ 0.32 g/t Au from 264m, and 32m @ 0.27 g/t Au from 284m. ERD-04 was collared on a high grade vein / fault target (with surface assays up to 16 g/t Au) and is located approximately 950m to the NE of ERD-01/-02. ERD-04 was designed to cut the interpreted controlling structure around 40m vertically below surface, and intersected intense faulting from the collar to around 56m downhole. No core was recovered from 45.1m to 49.2m downhole - suggesting either a possible void or milled zone - and was followed by 1.1m @ 1.4 g/t Au + 10 g/t Ag from 49.2m and 2m @ 4.6 g/t Au (silicified breccia) from 56m. A step back hole to ERD-04, designed to intersect this epithermal style mineralized zone at a deeper level, is expected to be incorporated in to the Ergama Phase II drill program. ERD-05 was collared on a satellite IP chargeability anomaly located approximately 1km ENE of drill holes ERD-01/-02. ERD-05 intersected approximately 150m of argillic altered andesites (from 180m downhole) with average gold grades of <0.15 g/t Au and a best intercept of 12m @ 0.19 g/t Au from 330m downhole. Accordingly, this sector represents a low priority target for follow-up work. Technical data relating to Ergama diamond drill holes ERD-01 to ERD-05 are given in the following table. **ENDS** Qualified Person                                                                                                                         The technical and scientific information contained in this news release has been reviewed and approved for release by Eric Roth, the Company's Qualified Person as defined by National Instrument 43-101. Mr Roth is the Company's Chief Operating Officer and Executive Director and holds a Ph.D. in Economic Geology from the University of Western Australia, is a Fellow of the Australian Institute of Mining and Metallurgy (AusIMM), and is a Fellow of the Society of Economic Geologists (SEG).  Mr Roth has 25 years of experience in international minerals exploration and mining project evaluation. About Mariana Resources Mariana Resources Ltd is a TSX.V and AIM (MARL) quoted exploration and development company with an extensive portfolio of gold, silver, and copper projects in South America, Turkey, and Ivory Coast. Mariana's most advanced asset is the Hot Maden gold-copper project in northeast Turkey, which is a joint venture with Turkish partner Lidya Madencilik (30% Mariana and 70% Lidya) and which is rapidly advancing to development.  On January 17, 2017, Mariana released the results of a Preliminary Economic Study ("PEA") which demonstrated exceptional potential economics for the Hot Maden Project (after-tax NPV and IRR of USD 1.37B and 153%, respectively) based on a development scenario incorporating a 1Mtpa underground mining / processing operation and the production of two saleable concentrates (a copper-gold concentrate and a gold-pyrite concentrate). This PEA was based on the updated (July 25, 2016) mineral resource estimate of 3.43 Moz gold equivalent (Indicated Category) and 0.09 Moz gold equivalent (Inferred Category) (100% basis) in the Main Zone, as well as a maiden 351,000 Moz gold equivalent (Inferred Category) (100% basis) resource in the New Southern Discovery. Elsewhere in Turkey, Mariana holds a 100% interest in the Ergama project where first drilling was reported on February 14, 2017, to have intersected porphyry-style gold-copper mineralisation. On October 7, 2016, Mariana announced the signing of a binding Term Sheet to acquire an indirect 80% interest in Ivory Coast-focused private exploration company Awalé Resources SARL ("Awalé").  Through the transaction Mariana will gain an immediate foothold in an established exploration portfolio with known gold mineralisation and artisanal gold workings, and which comprises i) 3 granted contiguous licenses (1,191 km2) in the Bondoukou area, and ii) 4 licenses under application (1,593 km2) in both the Bondoukou and Abengourou areas. The Boundoukou concessions lie along the southwestern extension of the Birimian Bole-Nangodi greenstone belt in adjacent Ghana, host to a number of high grade orogenic gold deposits. In southern Argentina, the Company's core gold-silver projects are Las Calandrias (100%), Sierra Blanca (100%), Los Cisnes (100%), and Bozal (100%). These projects are part of a 100,000+ Ha land package in the Deseado Massif epithermal gold-silver district in mining-friendly Santa Cruz Province. In Suriname, Mariana has a direct holding of 10.2% of the Nassau Gold project. The Nassau Gold Project is a 28,000 Ha exploration concession located approximately 125 km south east of the capital Paramaribo and immediately adjacent to Newmont Mining's 4.2Moz gold Merian project. *Au Equivalence (AuEq) calculated using a 100 day moving average of $US1,215/ounce for Au and $US2.13/pound for Cu as of May 29, 2016. No adjustment has been made for metallurgical recovery or net smelter return as these remain uncertain at this time. Based on grades and contained metal for Au and Cu, it is assumed that both commodities have reasonable potential to be economically extractable. Safe Harbour This press release contains certain statements which may be deemed to be forward-looking statements.  These forward-looking statements are made as at the date of this press release and include, without limitation, statements regarding discussions of future plans, the realization, cost, timing and extent of mineral resource estimates, estimated future exploration expenditures, costs and timing of the development of new deposits, success of exploration activities, permitting time lines, and requirements for additional capital.  The words "plans", "expects", "budget", "scheduled", "estimate", "forecasts", "intend", "anticipate", "believe", "may", "will", or similar expressions or variations of such words are intended to identify forward-looking statements.  Forward-looking statements are subject to known and unknown risks, uncertainties, assumptions and other factors that may cause actual results to vary materially from those expressed or implied by such forward-looking statements, including, but not limited to: the effects of general economic conditions; the price of gold, silver and copper; misjudgements in the course of preparing forward-looking statements; risks associated with international operations; the need for additional financing; risks inherent in exploration results; conclusions of economic evaluations; changes in project parameters; currency and commodity price fluctuations; title matters; environmental liability claims; unanticipated operational risks; accidents, labour disputes and other risks of the mining industry; delays in obtaining governmental approvals or in the completion of development or construction activities; political risk; and other risks and uncertainties described in the Company's annual financial statements for the most recently completed financial year which is available on the Company's website at www.marianaresources.com .  Although we believe that the expectations reflected in such forward-looking statements are based upon reasonable assumptions and have attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking statements, there may be other factors that cause results not to be as anticipated, estimated or intended.  There can be no assurance that such statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such forward-looking statements.  Accordingly, readers are cautioned not to place undue reliance on forward-looking statements.  We do not undertake to update any forward-looking statements, except in accordance with applicable securities laws. Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.


Further High Grade Gold-Copper Mineralisation Reported from Infill and Extension Drilling at the Hot Maden Project, NE Turkey. Mariana Resources Limited ('Mariana' or 'the Company'), the TSX.V and AIM (MARL) listed exploration and development company with projects in Turkey, South America, and Ivory Coast, is pleased to provide the following update on the ongoing diamond drill program at the high grade Hot Maden gold-copper project in NE Turkey. Assay results are reported for a total of 8 new drill holes (HTD-109, HTD-110, HTD-112, HTD-114 to HTD-117, and HTD-119), with a further 5 holes (HTD-107, HTD-108, HTD-111, HTD-113, and HTD-118) currently undergoing detailed geotechnical logging and with sampling/assaying still pending. Of the eight holes for which assays have been received, six were completed in the Main Zone resource area and the Southern Deposit; Figures 1 & 2); the remaining two holes (HTD-115 and HTD-119) represent the first scout holes to be completed in the Pre-1923 Russian Mining Area (Figure 3). An update on both the permitting of new drill holes and final results from the Phase I drill program at the Company's 100%-owned Ergama gold-copper project in western Turkey is also provided. Main Zone - Section 4,542,175N HTD-109:             75m @ 17.2 g/t Au + 1.89% Cu from 212m downhole. (Step forward    Including 13.7m @ 49.5 g/t Au + 2.95% Cu from 214.3m downhole, To HTD-106)       And 10m @ 39.9 g/t Au + 1.68% Cu from 237m downhole. (approximate true width of Au-Cu zone is 55m) HTD-110:             59m @ 18.2 g/t Au + 2.31% Cu from 190m downhole. (Step forward    Including 13m @ 50.2 g/t Au + 2.79% Cu from 190m downhole. to HTD-109)        (approximate true width of Au-Cu zone is 45m) HTD-116:             78m @ 5.2 g/t Au 3.76% Cu from 33m downhole. (Step forward    Including 9m @ 21.9 g/t Au + 6.49% Cu from 46m downhole. to HTD-110)        (approximate true width of Au-Cu zone is 60m) The Pre-1923 Russian Mine Area is a complex zone of mineralised veins and hydrothermal alteration, with these initial results being similar to those obtained from the first drill holes around the Main Zone discovery. As drill holes HTD-115 and HTD-119 were both collared 300m vertically above the uppermost known elevation of the Main Zone mineralisation, the possibilility that the narrow veins/veinlets intersected form part of a distal stringer zone to a buried massive sulfide system will be tested through future dilling. "Mariana's focused exploration and development work continues and today we announce further positive results from ongoing and increased drilling at Hot Maden, as well as the update on the Ergama project. "At Hot Maden, in the Main Zone, continued success from infill and step out drilling compliment our current results whilst maintaining our confidence in this zone. "In the Southern Zone these new results extend mineralisation and the strike length from the Main Zone to the Southern Zone which is continuing to grow. "Encouragingly, the 3rd operational rig in the Old Russian Mining Area has intersected narrow high grade gold and copper with higher grade zinc.  This is a complex part of the new untested system and these early positive results are assisting in the understanding of the mineralisation potential of this previously mined area. "At Ergama, in western Turkey, Mariana is awaiting permitting on 24 new holes in order to target, the hopefully better mineralised, potassic zone of the porphyry system to the south of the current 5 hole completed program. "Mariana continues to deliver exciting exploration results and I look forward to updating the market accordingly." Approximately 38,000 m of diamond drilling have now been completed by the Mariana-Lidya JV at Hot Maden since November, 2014 (Figures 1 - 3).  Recent drilling activities have focused on: - The planned infill drill program in the Main Zone resource area advanced with a further three holes (HTD-109, HTD-110, and HTD-106) being completed on section 4,542,175N. This program continues to be highly successful in confirming the internal continuity of the high-grade gold-copper mineralisation within the Main Zone. One step forward hole (HTD-114) was also completed on section 4,542,150N, with this hole intersecting gold-zinc mineralization along the margins of the Main Zone. On cross-section 4,542,175N (Figures 2 and 4), infill drill holes HTD-109 and HTD-110 returned 75m @ 17.2 g/t Au + 1.89% Cu from 212m downhole and 59m @ 18.2 g/t Au + 2.31% Cu from 190m downhole, respective. Both mineralised intervals are hosted within a multiphase, chalcopyrite-pyrite-hematite-jasper-bearing breccia, with a prominent "ultra high grade" gold zone once again being developed close to the eastern margin of the broader mineralised zone. Drill hole HTD-116 tested the near-surface portion of the Main Zone on section 4,542,175N and intersected both multiphase breccia and (faulted) massive sulfide type copper-gold mineralisation. Assays were received for two drill holes (HTD-112 and HTD-117) in the Southern Deposit, with the best results being reported from step back drill hole HTD-117 (7m @ 16.5 g/t Au + 0.30% Cu from 233m downhole, 2m @ 24.4 g/t Au + 0.94% Cu from 143m downhole, and 4m @ 7.2 g/t Au + 0.50% Cu from 181m downhole; section 4,541,900N). Encouraging intercepts were also returned from drill hole HTD-112, which was designed to extend known mineralisation in the Southern Deposit to the south, including 1m @ 7.4 g/t Au + 1.21% Cu from 58m downhole, 1m @ 29 g/t Au + 0.26% Cu from 62m downhole, and 4m @ 6.7 g/t Au + 0.35% Cu from 107m downhole, together with 22m @ 5.1% Zn from 292m downhole. Initial scout drilling has commenced in the Pre-1923 Russian Mining Area, in an area located approximately 1km to the south of the Southern Deposit. Two holes have been completed to date (HTD-115 and HTD-119), with HTD-115 intersecting narrow quartz vein gold-copper mineralisation and HTD-119 the interpreted hanging wall zinc zone. Key results include: The Pre-1923 Russian Mine Area is a complex zone of mineralised veins and hydrothermal alteration, with these initial results being similar to those obtained from the first drill holes around the Main Zone discovery. Further work will be required to identify the central part of the mineralized system. Table 1: Summary of assays for drill holes HTD-107 to HTD-119 (see also Figures 1 to 4 for drill hole locations and key cross sections). Mineralised intervals presented in Table 1 are drill intersection widths and may not represent true widths of mineralisation. Drill core obtained from the diamond drill program was dominantly HQ-sized core with the remainder being PQ-sized core. All drill core was photographed and quick logged prior to sampling. Standard sampling protocol involved the halving of all drill core and sampling over generally 1 m intervals (in clearly mineralised sections) or 2 m intervals (elsewhere), with one half of the core being placed in a sealed sample bag and dispatched to the analytical laboratory for analysis. Samples have been analysed at ALS Laboratories' facility in Izmir, western Turkey. All samples have been analysed for gold using a 30g Fire Assay with AAS finish (or Screen Fire Assay for higher grade samples), in addition to a 32 element ICP-AES analysis of an aqua regia digest.  Samples in which ICP analyses returned greater than the maximum detection limit for the elements Ag (10 ppm), Cu (10,000 ppm), Fe (15%), Pb (10,000 ppm), and Zn (10,000 ppm) were reanalysed using the AAS analytical technique, Standards and blanks were inserted in to the analytical sequence on the basis of one standard for every 20 samples, 2 blanks in every batch, and one duplicate every 40 samples. No HSE incidents have been reported during the current diamond drill program. Technical data relating to Hot Maden diamond drill holes HTD-107 to HTD-119 are given in the following table. Ergama Project Update Applications were presented in February 2017 for the approval of 24 potential new drill platforms located to the south of drill holes ERD-01 / ERD-02. Both ERD-01 and ERD-02 successfully intersected significant intervals of gold-bearing, porphyry-style quartz (-pyrite +/- chalcopyrite) stockwork mineralisation, with assay data confirming an overall increase in Au-Cu grades towards the south (see Mariana News Release dated February 14, 2017). Host rock alteration assemblages in ERD-01/ERD-02 are dominantly phyllic and also suggest that these drill holes may be distal to the potassic-altered (and potentially better mineralised) core of the porphyry system. Approval of these new drill platforms is expected shortly, with planning for the Phase II drill program now currently underway. A total of 5 diamond drill holes (for 2,225.8m of drilling, as per approved budget) were completed in the Phase I drill program; a further two planned holes were postponed until the approval of the new drill permits. Results obtained from the final three holes (ERD-03 to ERD-05) are summarized below. ERD-03 was collared on the NW margin of the main IP anomaly (and 250m W of drill holes ERD-01/-02), and intersected argillic altered volcanic and subvolcanic rocks (with locally minor phyllic alteration and quartz-pyrite stockworks). Intensely silicified carbonate rocks were also intersected near the end of the hole and these may represent rafts of material from the basement sequence. The best mineralised sections of ERD-03 are of similar tenor to those in ERD-01/-02, and include: 14m @ 0.24 g/t Au from 72m, 24m @ 0.22 g/t Au + 0.1% Cu from 156m, 2m @ 0.82 g/t Au from 252m, 4m @ 0.32 g/t Au from 264m, and 32m @ 0.27 g/t Au from 284m. ERD-04 was collared on a high grade vein / fault target (with surface assays up to 16 g/t Au) and is located approximately 950m to the NE of ERD-01/-02. ERD-04 was designed to cut the interpreted controlling structure around 40m vertically below surface, and intersected intense faulting from the collar to around 56m downhole. No core was recovered from 45.1m to 49.2m downhole - suggesting either a possible void or milled zone - and was followed by 1.1m @ 1.4 g/t Au + 10 g/t Ag from 49.2m and 2m @ 4.6 g/t Au (silicified breccia) from 56m. A step back hole to ERD-04, designed to intersect this epithermal style mineralized zone at a deeper level, is expected to be incorporated in to the Ergama Phase II drill program. ERD-05 was collared on a satellite IP chargeability anomaly located approximately 1km ENE of drill holes ERD-01/-02. ERD-05 intersected approximately 150m of argillic altered andesites (from 180m downhole) with average gold grades of <0.15 g/t Au and a best intercept of 12m @ 0.19 g/t Au from 330m downhole. Accordingly, this sector represents a low priority target for follow-up work. Technical data relating to Ergama diamond drill holes ERD-01 to ERD-05 are given in the following table. **ENDS** Qualified Person                                                                                                                         The technical and scientific information contained in this news release has been reviewed and approved for release by Eric Roth, the Company's Qualified Person as defined by National Instrument 43-101. Mr Roth is the Company's Chief Operating Officer and Executive Director and holds a Ph.D. in Economic Geology from the University of Western Australia, is a Fellow of the Australian Institute of Mining and Metallurgy (AusIMM), and is a Fellow of the Society of Economic Geologists (SEG).  Mr Roth has 25 years of experience in international minerals exploration and mining project evaluation. About Mariana Resources Mariana Resources Ltd is a TSX.V and AIM (MARL) quoted exploration and development company with an extensive portfolio of gold, silver, and copper projects in South America, Turkey, and Ivory Coast. Mariana's most advanced asset is the Hot Maden gold-copper project in northeast Turkey, which is a joint venture with Turkish partner Lidya Madencilik (30% Mariana and 70% Lidya) and which is rapidly advancing to development.  On January 17, 2017, Mariana released the results of a Preliminary Economic Study ("PEA") which demonstrated exceptional potential economics for the Hot Maden Project (after-tax NPV and IRR of USD 1.37B and 153%, respectively) based on a development scenario incorporating a 1Mtpa underground mining / processing operation and the production of two saleable concentrates (a copper-gold concentrate and a gold-pyrite concentrate). This PEA was based on the updated (July 25, 2016) mineral resource estimate of 3.43 Moz gold equivalent (Indicated Category) and 0.09 Moz gold equivalent (Inferred Category) (100% basis) in the Main Zone, as well as a maiden 351,000 Moz gold equivalent (Inferred Category) (100% basis) resource in the New Southern Discovery. Elsewhere in Turkey, Mariana holds a 100% interest in the Ergama project where first drilling was reported on February 14, 2017, to have intersected porphyry-style gold-copper mineralisation. On October 7, 2016, Mariana announced the signing of a binding Term Sheet to acquire an indirect 80% interest in Ivory Coast-focused private exploration company Awalé Resources SARL ("Awalé").  Through the transaction Mariana will gain an immediate foothold in an established exploration portfolio with known gold mineralisation and artisanal gold workings, and which comprises i) 3 granted contiguous licenses (1,191 km2) in the Bondoukou area, and ii) 4 licenses under application (1,593 km2) in both the Bondoukou and Abengourou areas. The Boundoukou concessions lie along the southwestern extension of the Birimian Bole-Nangodi greenstone belt in adjacent Ghana, host to a number of high grade orogenic gold deposits. In southern Argentina, the Company's core gold-silver projects are Las Calandrias (100%), Sierra Blanca (100%), Los Cisnes (100%), and Bozal (100%). These projects are part of a 100,000+ Ha land package in the Deseado Massif epithermal gold-silver district in mining-friendly Santa Cruz Province. In Suriname, Mariana has a direct holding of 10.2% of the Nassau Gold project. The Nassau Gold Project is a 28,000 Ha exploration concession located approximately 125 km south east of the capital Paramaribo and immediately adjacent to Newmont Mining's 4.2Moz gold Merian project. *Au Equivalence (AuEq) calculated using a 100 day moving average of $US1,215/ounce for Au and $US2.13/pound for Cu as of May 29, 2016. No adjustment has been made for metallurgical recovery or net smelter return as these remain uncertain at this time. Based on grades and contained metal for Au and Cu, it is assumed that both commodities have reasonable potential to be economically extractable. Safe Harbour This press release contains certain statements which may be deemed to be forward-looking statements.  These forward-looking statements are made as at the date of this press release and include, without limitation, statements regarding discussions of future plans, the realization, cost, timing and extent of mineral resource estimates, estimated future exploration expenditures, costs and timing of the development of new deposits, success of exploration activities, permitting time lines, and requirements for additional capital.  The words "plans", "expects", "budget", "scheduled", "estimate", "forecasts", "intend", "anticipate", "believe", "may", "will", or similar expressions or variations of such words are intended to identify forward-looking statements.  Forward-looking statements are subject to known and unknown risks, uncertainties, assumptions and other factors that may cause actual results to vary materially from those expressed or implied by such forward-looking statements, including, but not limited to: the effects of general economic conditions; the price of gold, silver and copper; misjudgements in the course of preparing forward-looking statements; risks associated with international operations; the need for additional financing; risks inherent in exploration results; conclusions of economic evaluations; changes in project parameters; currency and commodity price fluctuations; title matters; environmental liability claims; unanticipated operational risks; accidents, labour disputes and other risks of the mining industry; delays in obtaining governmental approvals or in the completion of development or construction activities; political risk; and other risks and uncertainties described in the Company's annual financial statements for the most recently completed financial year which is available on the Company's website at www.marianaresources.com .  Although we believe that the expectations reflected in such forward-looking statements are based upon reasonable assumptions and have attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking statements, there may be other factors that cause results not to be as anticipated, estimated or intended.  There can be no assurance that such statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such forward-looking statements.  Accordingly, readers are cautioned not to place undue reliance on forward-looking statements.  We do not undertake to update any forward-looking statements, except in accordance with applicable securities laws. Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.


Barkan A.,University of Oregon | Small I.,University of Western Australia
Annual Review of Plant Biology | Year: 2014

Pentatricopeptide repeat (PPR) proteins constitute one of the largest protein families in land plants, with more than 400 members in most species. Over the past decade, much has been learned about the molecular functions of these proteins, where they act in the cell, and what physiological roles they play during plant growth and development. A typical PPR protein is targeted to mitochondria or chloroplasts, binds one or several organellar transcripts, and influences their expression by altering RNA sequence, turnover, processing, or translation. Their combined action has profound effects on organelle biogenesis and function and, consequently, on photosynthesis, respiration, plant development, and environmental responses. Recent breakthroughs in understanding how PPR proteins recognize RNA sequences through modular base-specific contacts will help match proteins to potential binding sites and provide a pathway toward designing synthetic RNA-binding proteins aimed at desired targets. Copyright © 2014 by Annual Reviews.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-04-2016 | Award Amount: 10.41M | Year: 2017

Early life is an important window of opportunity to improve health across the full lifecycle. European pregnancy and child cohort studies together offer an unique opportunity to identify a wide range of early life stressors linked with individual biological, developmental and health trajectory variations, and to the onset and evolution of non-communicable diseases. LIFECYCLE will establish the EuroCHILD Cohort Network, which brings together existing, successful pregnancy and child cohorts and biobanks, by developing a governance structure taking account of national and European ethical, legal and societal implications, a shared data-management platform and data-harmonization strategies. LIFECYCLE will enrich this EuroCHILD Cohort Network by generating new integrated data on early life stressors related to socio-economic, migration, urban environment and life-style determinants, and will capitalize on these data by performing hypothesis-driven research on early life stressors influencing cardio-metabolic, respiratory and mental health trajectories during the full lifecycle, and the underlying epigenetic mechanisms. LIFECYCLE will translate these results into recommendations for targeted strategies and personalized prediction models to improve health trajectories for current and future Europeans generations by optimizing their earliest phase of life. To strengthen this long-term collaboration, LIFECYCLE will organize yearly international meetings open to pregnancy and child cohort researchers, introduce a Fellowship Training Programme for exchange of junior researchers between European pregnancy or child cohorts, and develop e-learning modules for researchers performing life-course health studies. Ultimately, LIFECYCLE will lead to a unique sustainable EuroCHILD Cohort Network, and provide recommendations for targeted prevention strategies by identification of novel markers of early life stressors related to health trajectories throughout the lifecycle.


Jablensky A.,University of Western Australia
World Psychiatry | Year: 2016

Despite historical assumptions to the contrary, there is little evidence that the majority of recognized mental disorders are separated by natural boundaries. Diagnostic categories defined by their clinical syndromes should be regarded as 'valid' only if they have been shown to be truly discrete entities. Most diagnostic concepts in psychiatry have not been demonstrated to be valid in this sense, though many possess 'utility' by virtue of the information they convey about presenting symptoms, outcome, treatment response and, in some instances, aetiology. While researchers in genetics, neurobiology and population epidemiology are increasingly more likely to adopt a continuum/dimensional view of the variation in symptomatology, clinicians prefer to hold on to the categorical approach embodied in current classifications such as ICD-10 and DSM-5. Both points of view have plausible justification in their respective contexts, but the way forward may be in their conceptual reconciliation.

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