Coventry, United Kingdom
Coventry, United Kingdom

The University of Warwick ) is a public research university in Coventry, England. It was founded in 1965 as part of a government initiative to expand access to higher education. Warwick Business School was established in 1967 and Warwick Medical School was opened in 2000. Warwick merged with Coventry College of Education in 1979 and Horticulture Research International in 2004.Warwick is primarily based on a 290 hectare campus on the outskirts of Coventry with a satellite campus in Wellesbourne and a London base at the Shard in central London. It is organised into four faculties—Arts, Medicine, Science and Social science—within which there are 32 departments. Warwick has around 23,400 full-time students and 1,390 academic and research staff and had a total income of £460 million in 2012/13, of which £84 million was from research grants and contracts. Warwick Arts Centre, a multi-venue arts complex in the university's main campus, is the largest venue of its kind in the UK outside London.Warwick consistently ranks in the top ten of all major national rankings of British universities and is the only multi-faculty institution aside from the Universities of Oxford, Cambridge, and Imperial to have never been ranked outside of the top ten. It is ranked by QS as the world's third best university under 50 years and as the world's 13th best university based on employer reputation. It was ranked 7th in the UK amongst multi-faculty institutions for the quality of its research in the 2014 Research Assessment Exercise. Entrance is competitive, with around 8.25 applicants per place for undergraduate study.Warwick is a member of AACSB, the Association of Commonwealth Universities, the Association of MBAs, EQUIS, the European University Association, the M5 Group, the Russell Group and Universities UK. It is the only European member of the Center for Urban Science and Progress, a collaboration with New York University. The university has extensive commercial activities, including the University of Warwick Science Park and Warwick Manufacturing Group. Wikipedia.

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University of Warwick | Date: 2015-05-14

A method of compressing a high dynamic range original image to provide compressed image data for use with (i) a high dynamic range decoder for viewing the high dynamic range image and (ii) a reduced bit depth decoder for viewing an image of lower dynamic range which has been derived from the high dynamic range original image. The difference between the image of the high dynamic range original image and the lower dynamic range is measured and that difference information is compressed. Compressed image data is produced comprising the compressed image of the lower dynamic range and the compressed image data.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SC1-PM-04-2016 | Award Amount: 9.71M | Year: 2017

The projects overall aim is to improve the health, development and quality of life of children and adults born very preterm (VPT, < 32 weeks of gestation) or very low birth weight (VLBW, < 1500g) approximately 50 000 births each year in Europe by establishing an ICT platform to integrate, harmonise and exploit the wealth of data from 20 European cohorts of VPT/VLBW children and adults and their families constituted from the early 1980s to the present, together with data from national registries. VPT/VLBW births have higher risks of cerebral palsy, visual and auditory deficits, impaired cognitive ability, psychiatric disorders and social problems than infants born at term and account for more than a third of the health and educational budgets for children. They may also face higher risks of non-communicable disease as they age. There is emerging evidence of reduced mental health, quality of life, partnering, family life and employment chances and wealth in adulthood. The platform will enable stratified sub-group analyses of sociodemographic and clinical characteristics, neonatal complications, and otherwise rare medical conditions that cannot be studied in national population cohorts. The broad temporal, geographic, cultural and health system diversity makes it possible to study the impact of socioeconomic and organisational contexts and determine the generalisability of outcomes for VPT/VLBW populations. The RECAP platform creates a value chain to promote research and innovation using population cohorts, beginning with the integration of VPT/VLBW cohorts to the translation and dissemination of new knowledge. It will be based on a sustainable governance framework, state-of-the art data management and sharing technologies, tools to strengthen research capacity, a hypothesis-driven research agenda and broad stakeholder participation, including researchers, clinicians, educators, policy makers and very preterm children and adults and their families.

Lewandowski J.R.,University of Warwick
Accounts of Chemical Research | Year: 2013

Dynamics are intimately linked to protein stability and play a crucial role in important biological processes, such as ligand binding, allosteric regulation, protein folding, signaling, and enzymatic catalysis. Solid-state NMR relaxation measurements allow researchers to determine the amplitudes, time scales, and under favorable conditions, directionality of motions at atomic resolution over the entire range of dynamic processes from picoseconds to milliseconds. Because this method allows researchers to examine both the amplitudes and time scales of motions in this range, they can link different tiers of protein motions in protein energy landscapes. As a result, scientists can better understand the relationships between protein motions and functions. Such studies are possible both with the primary targets of solid-state NMR studies, such as amyloid fibrils, membrane proteins, or other heterogeneous systems, and others that researchers typically study by solution NMR and X-ray crystallography. In addition, solid-state NMR, with the absence of tumbling in solution, eliminates the intrinsic size limitation imposed by slow tumbling of large proteins. Thus, this technique allows researchers to characterize interdomain and intermolecular interactions in large complexes at the atomic scale.In this Account, we discuss recent advances in solid-state relaxation methodology for studying widespread site-specific protein dynamics. We focus on applications involving magic angle spinning, one of the primary methods used in high-resolution solid-state NMR. We give an overview of challenges and solutions for measuring 15N and 13C spin-lattice relaxation (R 1) to characterize fast picosecond-nanosecond motions, spin-lattice in the rotating frame (R1ρ), and other related relaxation rates for characterization of picosecond-millisecond protein motions. In particular, we discuss the problem of separating incoherent effects caused by random motions from coherent effects arising from incomplete averaging of orientation- dependent NMR interactions. We mention a number of quantitative studies of protein dynamics based on solid-state relaxation measurements. Finally, we discuss the potential use of relaxation measurements for extracting the directionality of motions. Using the 15N and 13C R 1 and R1ρ measurements, we illustrate the backbone and side-chain dynamics in the protein GB1 and comment on this emerging dynamic picture within the context of data from solution NMR measurements and simulations. © 2013 American Chemical Society.

Troisi A.,University of Warwick
Chemical Society Reviews | Year: 2011

The theories developed since the fifties to describe charge transport in molecular crystals proved to be inadequate for the most promising classes of high mobility molecular semiconductors identified in the recent years, including for example pentacene and rubrene. After reviewing at an elementary level the classical theories, which still provide the language for the understanding of charge transport in these systems, this tutorial review outlines the recent experimental and computational evidence that prompted the development of new theories of charge transport in molecular crystals. A critical discussion will illustrate how very rarely it is possible to assume a charge hopping mechanism for high mobility organic crystals at any temperature. Recent models based on the effect of non-local electron-phonon coupling, dynamic disorder, coexistence of localized and delocalized states are reviewed. Additionally, a few more recent avenues of theoretical investigation, including the study of defect states, are discussed. © 2011 The Royal Society of Chemistry.

Woodruff D.P.,University of Warwick
Chemical Reviews | Year: 2013

A number of distinctly different experimental techniques have been developed to determine surface structures in a quantitative fashion, and as the information gained is specific to the method, some understanding of these methods and their complementary aspects is essential to evaluate the data that emerges. The dependence of the EXAFS amplitude on the direction of the polarization vector of the incident radiation also provides some information on the directions of the nearest-neighbor scatterers. In photoelectron diffraction, particularly in the energy-scan (PhD) mode, this interference occurs at the detector, and the (much larger) modulations of intensity with photon energy are also direction-dependent, providing a method to determine the complete local geometry. One important feature of all three of these local structural probes is that, because they involve measurements of core electron binding energies that are characteristic of the photo-absorbing atom, they are element specific.

Agency: GTR | Branch: BBSRC | Program: | Phase: Research Grant | Award Amount: 2.08M | Year: 2017

Lignin is a polymer found in plant cell walls, and is the most abundant source of renewable aromatic material on Earth. Lignin therefore represents a valuable raw material for generation of renewable chemicals, which will help society to reduce its dependance on crude oil for production of chemicals and materials such as plastics. Converting lignin into renewable chemicals is a very difficult challenge, because it is very hard to break down, and it is very heterogeneous (mixture of different structural units). Researchers at Warwick University have recently discovered several soil bacteria that can break down lignin, and specific enzyme biocatalysts that can oxidise lignin, and through a BBSRC/FAPESP FAPPA award have collaborated with CTBE in Brazil to identify new lignin-degrading enzymes through genome sequencing, and to develop new biosensors that could be used to engineer recombinant lignin-degrading micro-organisms that could break down lignin to high-value chemicals. The proposal brings together expertise in cellulosic ethanol production and metagenomic DNA sequencing (CTBE) with expertise in biocatalytic lignin valorisation (Warwick) and biocatalysis for high value chemicals production (Manchester, UCL). The overall aim is to use synthetic biology to break down lignin to intermediate ferulic acid, which has been generated from lignin via bacterial fermentation in previous work, and then to convert ferulic acid via biocatalysis into high-value chemicals. The project will : 1) optimise a lignin stream for the project from cellulosic bioethanol production at the CTBE pilot plant; 2) convert lignin into ferulic acid from lignin using synthetic biology; 3) enzymatically convert ferulic acid into a high-value pharmaceutical chemical, L-Dopa; 4) generate high value fragrance chemicals (coniferyl acetate, isoeugenol) from ferulic acid; 5) scale up chemicals production from renewable feedstocks; 6) assess the technical and sustainability impact of the methods developed in the project.

Agency: Cordis | Branch: H2020 | Program: FCH2-RIA | Phase: FCH-01-1-2016 | Award Amount: 3.49M | Year: 2017

The projects proposition and charter is to advance (MRL4 > MRL6) the critical steps of the PEM fuel cell assembly processes and associated in-line QC & end-of-line test / handover strategies and to demonstrate a route to automated volume process production capability within an automotive best practice context e.g. cycle time optimization and line-balancing, cost reduction and embedded / digitized quality control. The project will include characterization and digital codification of physical attributes of key materials (e.g. GDLs) to establish yield impacting digital cause and effects relationships within the value chain, from raw material supply / conversion / assembly through to in-service data analytics, aligning with evolving Industry 4.0 standards for data gathering / security, and line up-time, productivity monitoring. The expected outcome will be a blueprint for beyond current state automotive PEM fuel cell manufacturing capability in Europe. The project will exploit existing EU fuel cell and manufacturing competences and skill sets to enhance EU employment opportunities and competitiveness while supporting CO2 reduction and emissions reduction targets across the transport low emission vehicle sector with increased security of fuel supply (by utilizing locally produced Hydrogen).

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: NMBP-02-2016 | Award Amount: 8.05M | Year: 2017

Silicon carbide presents a high breakdown field (2-4 MV/cm) and a high energy band gap (2.33.2 eV), largely higher than for silicon. Within this frame, the cubic polytype of SiC (3C-SiC) is the only one that can be grown on a host substrate with the huge opportunity to grow only the silicon carbide thickness required for the targeted application. The possible growth on silicon substrate has remained for long period a real advantage in terms of scalability regarding the reduced diameter of hexagonal SiC wafer commercially available. Even the relatively narrow band-gap of 3C-SiC (2.3eV), which is often regarded as detrimental in comparison with other polytypes, can in fact be an advantage. The lowering of the conduction band minimum brings about a reduced density of states at the SiO2/3C-SiC interface and MOSFET on 3C-SiC has demonstrated the highest channel mobility of above 300 cm2/(Vxs) ever achieved on SiC crystals, prompting a remarkable reduction in the power consumption of these power switching devices. The electrical activity of extended defects in 3C SiC is a major concern for electronic device functioning. To achieve viable commercial yields the mechanisms of defects must be understood and methods for their reduction developed.. In this project new approaches for the reduction of defects will be used, working on new compliance substrates that can help to reduce the stress and the defect density at the same time. This growth process will be driven by numerical simulations of the growth and simulations of the stress reduction. The structure of the final devices will be simulated using the appropriated numerical tools where new numerical model will be introduced to take into account the properties of the new material. Thanks to these simulations tools and the new material with low defect density, several devices that can work at high power and with low power consumption will be realized inside the project.

Agency: Cordis | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 1.75M | Year: 2017

Cancer is considered as the second leading cause of death worldwide. It is important to develop methodologies that improve understanding of the disease condition and progression. Over the past few years, single cell biology has been performed using micro/nano robotics for exploration of the nanomechanical and electrophysiological properties of cells. However, most of the research so far has been empirical and the understanding of the mechanisms and thus possible for cancer therapy are limited. Therefore, a systematic approach to address this challenge using advanced micro/robotics techniques is timely and important to a wide range of the technologies where micro/nano manipulation and measurement are in demand. The proposed Micro/nano robotics for single cancer cells (MNR4SCell) project focuses on the staff exchange between the 8 world recognised institutions of EU and China, and the share of knowledge and ideas, and further the development of the leading edge technologies for the design, modelling, and control of micro/nano robotics and their applications in single cancer cell measurement, characterisation, manipulation, and surgery. This project meets the objectives and requirements of the Marie Skodowska-Curie Actions: Research and Innovation Staff Exchange (RISE). The ultimate goal of MNR4SCell is to establish long-term international and multidisciplinary research collaboration between Europe and China in the challenging field of micro/nano robotics for single cancer cells in the characterisation, diagnosis and targeted therapy. The synergistic approach and knowledge established by MNR4SCell will serve as the building blocks of the micro/nano robotics and biomedical applications, and thus keep the consortiums leading position in the world for potential major scientific and technological breakthroughs in nanotechnology and cancer therapy.

Agency: Cordis | Branch: H2020 | Program: MSCA-COFUND-FP | Phase: MSCA-COFUND-2015-FP | Award Amount: 4.01M | Year: 2017

The Warwick Interdisciplinary Research Leadership Programme (WIRL) is a major new initiative by the University of Warwick to train future generations of Research Leaders in Europe. Warwick is known for its experience in interdisciplinary postdoctoral training through its leading Institute of Advanced Study (IAS), its innovative cross-sectoral research carried out through its ten Global Research Priorities (GRPs) and its international environment and reputation created through distinctive global partnerships and research collaborations. WIRL will build on this background to train 30 international researchers over five years to form a group of New Research Leaders who will contribute to the European Unions plans to build a dynamic, knowledge-based economy and to improve economic growth. Warwicks experience shows that Research Leadership is greatly enabled through close mentoring, international collaborations and the opportunity to build an independent research profile within the first five years of post-PhD research. Since 2007 the IAS has hosted a well-established research development programme, delivering complementary skills training to early career and experienced researchers. WIRL will be a major step forward in Warwicks Postdoctoral training programme. It will expand the current UK-centred programme into one with a pan-European focus and global reach. WIRL will create an environment for Fellows to develop the skills and gain the experience required to become Research Leaders in their fields within and beyond academia. This research environment is underpinned by the Universitys 10 interdisciplinary GRPs that sit across academic disciplines, representing Warwicks key areas of research excellence and engagement. GRPs bring together research strengths from across the University, giving them clear thematic identities that show where Warwick can make a significant and distinctive contribution to the resolution of some of the worlds most pressing issues.

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