The University of Virginia , often referred to as simply Virginia, is a public research university in Charlottesville, Virginia. UVA is known for its historic foundations, student-run honor code, and secret societies.Its initial Board of Visitors included U.S. Presidents Thomas Jefferson, James Madison, and James Monroe. President Monroe was the sitting President of the United States at the time of the founding; Jefferson and Madison were the first two rectors. UVA was established in 1819, with its Academical Village and original courses of study conceived and designed entirely by Jefferson. UNESCO designated it a World Heritage Site in 1987, an honor shared with nearby Monticello.The first university of the American South elected to the Association of American Universities in 1904, UVA is classified as Very High Research Activity in the Carnegie Classification. The university is affiliated with 7 Nobel Laureates, and has produced 7 NASA astronauts, 7 Marshall Scholars, 4 Churchill Scholars, 29 Truman Scholars, and 50 Rhodes Scholars, the most of any state-affiliated institution in the U.S. Supported in part by the Commonwealth, it receives far more funding from private sources than public, and its students come from all 50 states and 147 countries. It also operates a small liberal arts branch campus in the far southwestern corner of the state.Since 1953, Virginia's athletic teams have competed in the Atlantic Coast Conference of Division I of the NCAA and are known as the Virginia Cavaliers. Virginia won its 7th men's soccer national title in December 2014, bringing its collective total to 24 National Championships, and 63 ACC Championships since 2002 , the most of any conference member during that time. Wikipedia.
University of Virginia and Beth Israel Deaconess Medical Center | Date: 2016-08-03
Methods, systems, and computer-readable media for rapid 3D dynamic arterial spin labeling with a sparse model-based image reconstruction are disclosed. In one embodiment, a method includes acquiring magnetic resonance data associated with an area of interest of a subject. The magnetic resonance data includes associated with arterial spin labeling (ASL) of the area of interest. The method also includes performing image reconstruction on the acquired resonance data. The image reconstruction includes compressed sensing enforcing a model-based sparsity constraint, where the model-based sparsity constraint is based on an ASL signal prototype dictionary.
University of Virginia | Date: 2016-10-17
Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject. A current location of the needle may be distinguished from another location based on an algorithm including the pressure frequency information and the cardiac waveform information.
University of Virginia | Date: 2016-08-04
A gait device and method for rehabilitating or developing a subjects lower extremity. The device may include a movable belt configured for the subject to ambulate thereon; a track provided above the movable belt that is generally aligned with the movable belt; and a coupler that is configured to travel along the track and attach to the distal portion of the lower extremity of the subject while the subject is ambulating on the movable belt.
Technion Research And Development Foundation Ltd. and University of Virginia | Date: 2016-10-17
There are provided methods and compositions useful in cell-cell fusion using Fusion Family (FF) proteins of nematode origin. There are further provided antinematodal methods and compositions, utilizing fusogenic proteins of the nematode Fusion Family.
University of Iowa and University of Virginia | Date: 2016-09-16
A method for treating intractable pain via electrical stimulation of the spinal cord. Remote, non-contact stimulation of a selected region of spinal cord is achieved by placement of a transceiver patch directly on the surface of that region of spinal cord, with said patch optionally being inductively coupled to a transmitter patch of similar size on either the outer or inner wall of the dura surrounding that region of the spinal cord. By inductively exchanging electrical power and signals between said transmitter and transceiver patches, and by carrying out the necessary electronic and stimulus signal distribution functions on the transceiver patch, the targeted dorsal column axons can be stimulated without the unintended stray stimulation of nearby dorsal rootlets. Novel configurations of a pliable surface-sheath and clamp or dentate ligament attachment features which realize undamaging attachment of the patch to the spinal cord are described.
Antonovics J.,University of Virginia
Philosophical Transactions of the Royal Society B: Biological Sciences | Year: 2017
This article overviews the dynamics of disease transmission in one-host-one-parasite systems. Transmission is the result of interacting host and pathogen processes, encapsulated with the environment in a ‘transmission triangle’. Multiple transmission modes and their epidemiological consequences are often not understood because the direct measurement of transmission is difficult. However, its different components can be analysed using nonlinear transmission functions, contact matrices and networks. A particular challenge is to develop such functions for spatially extended systems. This is illustrated for vector transmission where a ‘perception kernel’ approach is developed that incorporates vector behaviour in response to host spacing. A major challenge is understanding the relative merits of the large number of approaches to quantifying transmission. The evolution of transmission mode itself has been a rather neglected topic, but is important in the context of understanding disease emergence and genetic variation in pathogens. Disease impacts many biological processes such as community stability, the evolution of sex and speciation, yet the importance of different transmission modes in these processes is not understood. Broader approaches and ideas to disease transmission are important in the public health realm for combating newly emerging infections. © 2017 The Author(s) Published by the Royal Society. All rights reserved.
University of Virginia | Date: 2017-03-08
Provided are isolated TCRs, TCR-like molecules, and portions thereof that bind to phosphopeptide-HLA-A2 complexes. The isolated TCRs, TCR-like molecules, or portions are optionally soluble TCRs, TCR-like molecules, or portions. Also provided are isolated nucleic acids encoding the disclosed TCRs, TCR-like molecules, or portions; host cells that contain the disclosed TCRs, TCR-like molecules, or portions; pharmaceutical compositions that include the disclosed TCRs, TCR-like molecules, portions, nucleic acids, and/or T cells; kits; and methods of using the same.
Pu L.,University of Virginia
Accounts of chemical research | Year: 2012
The development of automated, high-throughput organic synthesis and screening techniques has created an urgent demand for methods that rapidly determine the enantiomeric composition of chiral compounds. Enantioselective fluorescent sensors offer the potential for real-time, high-sensitivity techniques for determining enantiomeric data in high-throughput chiral assays. In this Account, we describe a range of fluorescent sensors derived from 1,1'-bi-2-naphthol (BINOL), a readily available biaryl compound with axial chirality. We show that BINOL can be used to construct structurally diverse, chiral fluorescent sensors to carry out highly enantioselective, sensitive recognition of chiral amino alcohols, α-hydroxycarboxylic acids, and amino acid derivatives. For example, we prepared an (S)-BINOL derivative whose 3,3'-positions are attached to two chiral amino alcohol units, each having two phenyl substituents. This compound shows a fluorescence enhancement of 950-fold in the presence of (S)-mandelic acid but very little change in the presence of (R)-mandelic acid. It also allows the enantiomers of this α-hydroxycarboxylic acid to be visually discriminated by an enantioselective precipitation process. A structurally similar (S)-BINOL-amino alcohol molecule, but with three rather than two phenyl substitutents in each of the two amino alcohol units, was found to exhibit generally enantioselective fluorescence responses toward structurally diverse α-hydroxycarboxylic acids. We further prepared a pseudoenantiomeric analogue of this compound from (R)-H(8)BINOL, which has the opposite chiral configuration at both the biaryl center as well as the pendant amino alcohols. These two compounds have opposite enantioselectivity in the recognition of a chiral substrate, with distinctly different fluorescence emission wavelengths. By mixing them together, we developed a pseudoenantiomeric sensor pair to facilitate chiral assays. Using this pseudoenantiomeric sensor pair allows both the concentration and the enantiomeric composition of a substrate to be determined in a single fluorescence measurement. We synthesized another compound by ligating a terpyridine unit to BINOL and found that coordination of a Cu(II) ion to the terpyridine unit almost completely quenched its fluorescence. Displacement of the Cu(2+) ion from this complex by chiral amino alcohols leads to enantioselective fluorescence enhancement. This BINOL-terpyridine-Cu(II) complex also exhibits enantioselective gel collapsing in the presence of chiral amino alcohols, providing a new visual chiral discrimination method. When a series of light-absorbing conjugated units are attached to the BINOL structure, the resulting multiarmed dendritic molecules show greatly amplified fluorescence responses. Thus, the light harvesting effect of dendrimers can be used to greatly increase the sensitivity of the fluorescent sensors. The progress described here demonstrates that highly enantioselective and sensitive fluorescent sensors can be obtained through a systematic investigation of the structure-property relation between the sensors and the substrates. These sensors show great potential for the development of rapid assays of chiral organic compounds.
Ravichandran K.S.,University of Virginia
Journal of Experimental Medicine | Year: 2010
Everyday we turnover billions of cells. The quick, efficient, and immunologically silent disposal of the dying cells requires a coordinated orchestration of multiple steps, through which phagocytes selectively recognize and engulf apoptotic cells. Recent studies have suggested an important role for soluble mediators released by apoptotic cells that attract phagocytes ("find-me" signals). New information has also emerged on multiple receptors that can recognize phosphatidylserine, the key "eat-me" signal exposed on the surface of apoptotic cells. This perspective discusses recent exciting progress, gaps in our understanding, and the conflicting issues that arise from the newly acquired knowledge. © 2010 Ravichandran.
Ravichandran K.,University of Virginia
Immunity | Year: 2011
Prompt and efficient clearance of apoptotic cells is necessary to prevent secondary necrosis of dying cells and to avoid immune responses to autoantigens. Recent studies have shed light on how apoptotic cells through soluble " find-me" signals advertise their presence to phagocytes at the earliest stages of cell death. Phagocytes sense the find-me signal gradient, and in turn the presence of dying cells, and migrate to their vicinity. The apoptotic cells also expose specific " eat-me" signals on their surface that are recognized by phagocytes through specific engulfment receptors. This review covers the recent progress in the areas of find-me and eat-me signals and how these relate to prompt and immunologically silent clearance of apoptotic cells. © 2011 Elsevier Inc.