Charlottesville, VA, United States

University of Virginia

www.virginia.edu
Charlottesville, VA, United States

The University of Virginia , often referred to as simply Virginia, is a public research university in Charlottesville, Virginia. UVA is known for its historic foundations, student-run honor code, and secret societies.Its initial Board of Visitors included U.S. Presidents Thomas Jefferson, James Madison, and James Monroe. President Monroe was the sitting President of the United States at the time of the founding; Jefferson and Madison were the first two rectors. UVA was established in 1819, with its Academical Village and original courses of study conceived and designed entirely by Jefferson. UNESCO designated it a World Heritage Site in 1987, an honor shared with nearby Monticello.The first university of the American South elected to the Association of American Universities in 1904, UVA is classified as Very High Research Activity in the Carnegie Classification. The university is affiliated with 7 Nobel Laureates, and has produced 7 NASA astronauts, 7 Marshall Scholars, 4 Churchill Scholars, 29 Truman Scholars, and 50 Rhodes Scholars, the most of any state-affiliated institution in the U.S. Supported in part by the Commonwealth, it receives far more funding from private sources than public, and its students come from all 50 states and 147 countries. It also operates a small liberal arts branch campus in the far southwestern corner of the state.Since 1953, Virginia's athletic teams have competed in the Atlantic Coast Conference of Division I of the NCAA and are known as the Virginia Cavaliers. Virginia won its 7th men's soccer national title in December 2014, bringing its collective total to 24 National Championships, and 63 ACC Championships since 2002 , the most of any conference member during that time. Wikipedia.


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Patent
University of Iowa and University of Virginia | Date: 2017-02-21

This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are installed as a source of electrical stimulation and pain relief. The floating electrodes can be flexibly mounted to the substrate such that when the electrode array is implanted into the subject, individual electrodes float or move resiliently relative to the substrate to an extent sufficient to accommodate pulsations of the surface of the spinal cord within the dura.


Patent
University of Virginia | Date: 2017-06-21

A method, system, and device for improving the accuracy of a continuous glucose monitoring sensor by estimating a CGM signal at a time t+PH using a value of CGM at time t, using a real-time short-time glucose prediction horizon to estimate the real time denoised CGM value with a noise estimation algorithm.


Patent
University of Virginia | Date: 2017-06-21

This invention relates to compounds that bind to wild-type CBF and inhibit CBF binding to RUNX proteins. The potent compounds of the invention inhibit this protein-protein interaction at low micromolar concentrations, using allosteric mechanism to achieve inhibition, displace wild-type CBF from RUNX1 in cells, change occupancy of RUNX1 on target genes, and alter gene expression of RUNX1 target genes. These inhibitors show clear biological effects consistent with on-target RUNX protein activity. Pharmaceutical compositions containing a compound of the invention and a pharmaceutically acceptable carrier represent a separate embodiment of the invention. Another embodiment of the invention are methods of treating a RUNX-signaling-dependent cancer that expresses wild-type CBF in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention. In one embodiment, the cancer is selected from the group consisting of a RUNX-signaling-dependent leukemia that expresses wild-type CBF, lung cancer, bladder cancer, ovarian cancer, uterine cancer, endometrial cancer, breast cancer, liver cancer, pancreatic cancer, stomach cancer, cervical cancer, lymphoma, leukemia, acute myeloid leukemia, acute lymphocytic leukemia, salivary gland cancer, bone cancer, brain cancer, colon cancer, rectal cancer, colorectal cancer, kidney cancer, skin cancer, melanoma, squamous cell carcinoma of the tongue, pleomorphic adenoma, hepatocellular carcinoma, pancreatic cancer, squamous cell carcinoma, and/or adenocarcinoma. In another embodiment, the compounds of the invention can be used to treat a leukemia, lung cancer, ovarian cancer, and/or breast cancer.


Patent
University of Virginia and Princeton University | Date: 2017-02-14

Embodiments of the present disclosure provide for methods of hydrocarbon functionalization, methods and systems for converting a hydrocarbon into a compound including at least one group ((e.g., hydroxyl group) (e.g., methane to methanol)), functionalized hydrocarbons, and the like.


A system for classifying cardiac rhythms is disclosed. The system includes one or more processors, one or more computer-readable tangible storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include first program instructions to obtain data representative of a time series of the times between heartbeats. The program instructions further comprise second program instructions to segment the time series into a plurality of segments. The program instructions further comprise third program instructions to calculate a plurality of parameters corresponding to each of the 30-second segments. The program instructions further comprise fourth program instructions to analyze the obtained data and the calculated parameters using a plurality of multivariable algorithms for rhythm classification. The program instructions further comprise fifth program instructions to synthesize the results of the plurality of multivariable algorithms to formulate a single rhythm classification.


Patent
University of Virginia | Date: 2017-03-23

Devices and methods for tendon to bone healing are disclosed. In one embodiment, a tendon fixation method for tendon to bone healing includes anchoring suture anchors to a bone region. Sutures may be securely engaged to associated suture anchors and the sutures may be fastened to a fixation device. The fixation device may include a base with a plurality of openings to securely receive the sutures and one or more fastening members and/or fastening surfaces. The fixation device may be secured to a tendon thereby increasing a resistance to rotation or axial motion. In this respect, the contact area between the tendon and the bone region may be increased such that a compression force may be evenly distributed from the base of the fixation device along a tendon region of the tendon. In one embodiment, a plurality of elongate fastening members can be removably inserted through the opening until perforating a predetermined depth of the subchondral bone region and being stopped at the predetermined depth by contacting an upper surface of the base.


Patent
University of Virginia and Deshpande | Date: 2017-07-12

An impulse mitigation system configured to mitigate blast impulse directed to a surface (or structure or target). The system includes a substrate in communication with the surface (or structure or target), wherein the substrate is configured to receive an impulse directed to the surface (or structure or target) and then relocate from the surface (or structure or target) in response to received impulse.


Patent
University of Virginia | Date: 2017-04-26

Systems and methods for use in monitoring treatment of pressure-related conditions, such as hydrocephalus, include an implantable vessel, and a meter including one or more microfluidic channels connected to the vessel. The microfluidic channels may be configured to detect at least one of pressure and fluid flow rate through the vessel and to be read out remotely by a wirelessly coupled external device. The meter may include a passive resonant (LC) circuit. A dynamic flap may be included in the microfluidic channel that may act as part of the LC circuit. An external device may also be configured to inductively couple remotely to the LC circuit, with-out physical connections to the implantable vessel or pressure meter, and to display a pressure acting on the pressure meter and/or a fluid flow through the meter.


Patent
University of Virginia | Date: 2017-01-27

The gene responsible for encoding SERT has a functional polymorphism at the 5-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3 UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.


Ravichandran K.,University of Virginia
Immunity | Year: 2011

Prompt and efficient clearance of apoptotic cells is necessary to prevent secondary necrosis of dying cells and to avoid immune responses to autoantigens. Recent studies have shed light on how apoptotic cells through soluble " find-me" signals advertise their presence to phagocytes at the earliest stages of cell death. Phagocytes sense the find-me signal gradient, and in turn the presence of dying cells, and migrate to their vicinity. The apoptotic cells also expose specific " eat-me" signals on their surface that are recognized by phagocytes through specific engulfment receptors. This review covers the recent progress in the areas of find-me and eat-me signals and how these relate to prompt and immunologically silent clearance of apoptotic cells. © 2011 Elsevier Inc.

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