Versailles, France
Versailles, France

Versailles Saint-Quentin-en-Yvelines University is a French public university created in 1991, located in the department of Yvelines and since 2002 in Hauts-de-Seine. It is mainly located in the cities of Versailles, Saint-Quentin-en-Yvelines, Mantes-en-Yvelines and Vélizy-Villacoublay / Rambouillet, with a total of eight campuses. It is one of the five universities of the Academy of Versailles.It is one of the four universités nouvelles inaugurated in Île-de-France region after the plan université 2000 . It has 19,000 students, 752 staff people and 1,389 teachers and researchers. 285 teachers outside of the university come each year to provide courses.The subjects taught are the exact science, the social science, the political science, engineering, technology and medicine. It also provide courses concerning the relationship between economy, ethics, natural environment and sustainable development. Wikipedia.


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Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETHPC-1-2014 | Award Amount: 7.97M | Year: 2015

The main target of the Mont-Blanc 3 project European Scalable and power efficient HPC platform based on low-power embedded technology is the creation of a new high-end HPC platform (SoC and node) that is able to deliver a new level of performance / energy ratio whilst executing real applications. The technical objectives are: 1. To design a well-balanced architecture and to deliver the design for an ARM based SoC or SoP (System on Package) capable of providing pre-exascale performance when implemented in the time frame of 2019-2020. The predicted performance target must be measured using real HPC applications. 2. To maximise the benefit for HPC applications with new high-performance ARM processors and throughput-oriented compute accelerators designed to work together within the well-balanced architecture. 3. To develop the necessary software ecosystem for the future SoC. This additional objective is important to maximize the impact of the project and make sure that this ARM architecture path will be successful in the market. The project shall build upon the previous Mont-Blanc & Mont-Blanc 2 FP7 projects, with ARM, BSC & Bull being involved in Mont-Blanc 1, 2 and 3 projects. It will adopt a co-design approach to make sure that the hardware and system innovations are readily translated into benefits for HPC applications. This approach shall integrate architecture work (WP3 & 4 - on balanced architecture and computing efficiency) together with a simulation work (to feed and validate the architecture studies ) and work on the needed software ecosystem.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.36M | Year: 2017

Mitigation of climate change is a key scientific and societal challenge and also a headline target of the EU2020 strategy. Strong reductions in greenhouse gas emissions are necessary to reach the global warming target agreed on at the 2015 United Nations Convention of Parties in Paris. Such emission reductions can only be achieved if sources are properly quantified and mitigation efforts are verified, but there are large discrepancies between official emission inventories and estimates derived from direct measurement of the air. MEMO2 will contribute to the EU2020 targets with a focus on methane (CH4), the second most important greenhouse gas after CO2 and one of Europes most important energy sources. CH4 emissions are a major contributor to Europes global warming impact, but they are also a good target for climate change mitigation because of a rather short lifetime of 10 years (policy-maker compatible) and several sources offering possibilities of no-regret emission reduction (landfills, gas leaks, manure). However CH4 emissions are not well quantified yet. MEMO2 will bridge the gap between large-scale scientific estimates from in situ monitoring programs and the bottom-up estimates of emissions from local sources that are used in the national reporting. MEMO2 will identify and evaluate CH4 emissions and support mitigation measures by I) developing new and advanced mobile methane measurements tools and networks, isotopic source identification, and modelling at different scales, and II) educating a new generation of crossthinking scientists, which are able to effectively implement novel measurement and modelling tools in an interdisciplinary and intersectoral context. The 9 beneficiaries and 13 non-academic partners of MEMO2 offer a wellstructured intersectoral training programme to equip young researchers with strong scientific and personal competencies, which will enhance their employability as well as European innovation capacity in the future.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EO-2-2015 | Award Amount: 2.99M | Year: 2016

With the start of the SENTINEL era, an unprecedented amount of Earth Observation (EO) data will become available. Currently there is no consistent but extendible and adaptable framework to integrate observations from different sensors in order to obtain the best possible estimate of the land surface state. MULTIPY proposes a solution to this challenge. The project will develop an efficient and fully traceable platform that uses state-of-the-art physical radiative transfer models, within advanced data assimilation (DA) concepts, to consistently acquire, interpret and produce a continuous stream of high spatial and temporal resolution estimates of land surface parameters, fully characterized. These inferences on the state of the land surface will be the result from the coherent joint interpretation of the observations from the different Sentinels, as well as other 3rd party missions (e.g. ProbaV, Landsat, MODIS). The framework allows users to exchange components as plug-ins according to their needs. The proposal is based on the EO-LDAS concepts developed within several ESA-funded projects, which have shown the feasibility of producing estimates of the land surface parameters by combining different sets of observations through the use of radiative transfer models. We will provide a fully generic flexible data retrieval platform for Copernicus services that provides integrated and consistent data products in an easily accessible virtual machine with advanced visualisation tools. Users will be engaged throughout the process and trained. Moreover, user demonstrator projects include applications to crop monitoring & modelling, forestry, biodiversity and nature management. Another user demonstrator project involves providing satellite operators with an opportunity to cross-calibrate their data to the science-grade Sentinel standards.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EINFRA-9-2015 | Award Amount: 7.64M | Year: 2015

OpenDreamKit will deliver a flexible toolkit enabling research groups to set up Virtual Research Environments, customised to meet the varied needs of research projects in pure mathematics and applications and supporting the full research life-cycle from exploration, through proof and publication, to archival and sharing of data and code. OpenDreamKit will be built out of a sustainable ecosystem of community-developed open software, databases, and services, including popular tools such as LinBox, MPIR, Sage(sagemath.org), GAP, PariGP, LMFDB, and Singular. We will extend the Jupyter Notebook environment to provide a flexible UI. By improving and unifying existing building blocks, OpenDreamKit will maximise both sustainability and impact, with beneficiaries extending to scientific computing, physics, chemistry, biology and more and including researchers, teachers, and industrial practitioners. We will define a novel component-based VRE architecture and the adapt existing mathematical software, databases, and UI components to work well within it on varied platforms. Interfaces to standard HPC and grid services will be built in. Our architecture will be informed by recent research into the sociology of mathematical collaboration, so as to properly support actual research practice. The ease of set up, adaptability and global impact will be demonstrated in a variety of demonstrator VREs. We will ourselves study the social challenges associated with large-scale open source code development and of publications based on executable documents, to ensure sustainability. OpenDreamKit will be conducted by a Europe-wide demand-steered collaboration, including leading mathematicians, computational researchers, and software developers long track record of delivering innovative open source software solutions for their respective communities. All produced code and tools will be open source.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: SEAC-1-2015 | Award Amount: 1.80M | Year: 2016

The general objective of the EDU-ARCTIC project is a cross-country adaptation of innovative practices in science education in Europe. EDU-ARCTIC will provide a custom-designed large-scale program to strengthen schools science education. EDU-ARCTIC will use innovative online tools for interactive open-access available for everyone to link Arctic research and school education in Europe. The program is dedicated to young students in the age of 13 to 20 and their teachers. The program will be based on 5 main components: 1) Broadcasts (webinar transmissions) of online lessons from polar stations on natural sciences and polar research related to important societal challenges. The content of webinars will be adopted to school curricula at various levels (regional, national and European); 2) Polarpedia an online developing encyclopedia with scientific expressions, educational resources and dictionaries in at least 5 national European languages; 3) Arctic competitions for European pupils cooperating with their teachers, in which prize winners will be able to participate in polar expedition; 4) Monitoring system: all schools in Europe will be invited to participate in a program based on monitoring of phenological observations in schools surroundings, a web based portal for registrations and access to accumulated data. 5) Teachers workshops and trainings. The novel educational programme elaborated within EDU-ARCTIC will give European pupils the opportunity to get insights in Research and Innovation process by access to (two-way communication) lecture transmissions from polar stations, participation in arctic competitions and environmental monitoring in their own surroundings. The interaction with real-time scientific work will contribute to increased interest among young boys and girls in choosing STEM careers. The innovative EDU-ARCTIC program will attract young boys and girls by its novel approach to STEM skills, especially science.


Grant
Agency: European Commission | Branch: FP7 | Program: ERC-SyG | Phase: ERC-2013-SyG | Award Amount: 13.60M | Year: 2014

P is an earthbound and finite element and the prospect of constrained access to mineable P resources has already triggered geopolitical disputes. In contrast to P, availabilities of carbon (C) and nitrogen (N) to ecosystems are rapidly increasing in most areas of the globe. The resulting imminent change in the stoichiometry of available elements will have no equivalent in the Earths history and will bear profound, yet, unknown consequences for life, the Earth System and human society. The ongoing shifts in C:N:P balances in ecosystems will necessarily affect the structure, function and diversity of the Earth system. P-market crises might put pressure on the global food system and create environmental ripple effects ranging from expansion of agricultural land to P-price-induced changes in land management exacerbating the stoichiometric resource imbalance. Yet, the impacts of this unprecedented human disturbance of elemental stoichiometry remain a research enigma. The IMBALANCE-P-team, that gathers four leading researchers in the fields of ecosystem diversity and ecology, biogeochemistry, Earth System modelling, and global agricultural and resource economics, is formidably positioned to address this Earth System management challenge by providing improved understanding and quantitative foresight needed to formulate a range of policy options that will contain the risks and mitigate the consequences of stoichiometric imbalances. IMBALANCE-P will integrate some of Europes leading integrated assessment and Earth system models, calibrated using ecosystem nutrient limitation data obtained from field experiments. The project will establish an international process of science-based P-diplomacy.


Serre C.,University of Versailles
Angewandte Chemie - International Edition | Year: 2012

A new job: Highly fluorinated porous MOFs (see picture) that exhibit a superior hydrophobic character can possibly find an application as new superhydrophobic adsorbents in aqueous-phase separation processes. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Devic T.,University of Versailles | Serre C.,University of Versailles
Chemical Society Reviews | Year: 2014

This article focuses on high valence 3p and transition metal based metal organic frameworks. In the first part we will discuss the complex solution chemistry of these metals which makes this sub-class of MOFs more of a challenge than the traditional low valence metal based MOFs. This is followed by a short review of the different classes of solids based on phosphonates, carboxylates and other linkers. Finally, we report some of the most relevant properties of these solids such as their chemical or thermal stability as well as their catalytic, redox- and photo-activities. This journal is © the Partner Organisations 2014.


Germain D.P.,University of Versailles
Orphanet Journal of Rare Diseases | Year: 2010

Fabry disease (FD) is a progressive, X-linked inherited disorder of glycosphingolipid metabolism due to deficient or absent lysosomal α-galactosidase A activity. FD is pan-ethnic and the reported annual incidence of 1 in 100,000 may underestimate the true prevalence of the disease. Classically affected hemizygous males, with no residual α-galactosidase A activity may display all the characteristic neurological (pain), cutaneous (angiokeratoma), renal (proteinuria, kidney failure), cardiovascular (cardiomyopathy, arrhythmia), cochleo-vestibular and cerebrovascular (transient ischemic attacks, strokes) signs of the disease while heterozygous females have symptoms ranging from very mild to severe. Deficient activity of lysosomal α-galactosidase A results in progressive accumulation of globotriaosylceramide within lysosomes, believed to trigger a cascade of cellular events. Demonstration of marked α-galactosidase A deficiency is the definitive method for the diagnosis of hemizygous males. Enzyme analysis may occasionnally help to detect heterozygotes but is often inconclusive due to random X-chromosomal inactivation so that molecular testing (genotyping) of females is mandatory. In childhood, other possible causes of pain such as rheumatoid arthritis and 'growing pains' must be ruled out. In adulthood, multiple sclerosis is sometimes considered. Prenatal diagnosis, available by determination of enzyme activity or DNA testing in chorionic villi or cultured amniotic cells is, for ethical reasons, only considered in male fetuses. Pre-implantation diagnosis is possible. The existence of atypical variants and the availability of a specific therapy singularly complicate genetic counseling. A disease-specific therapeutic option - enzyme replacement therapy using recombinant human α-galactosidase A - has been recently introduced and its long term outcome is currently still being investigated. Conventional management consists of pain relief with analgesic drugs, nephroprotection (angiotensin converting enzyme inhibitors and angiotensin receptors blockers) and antiarrhythmic agents, whereas dialysis or renal transplantation are available for patients experiencing end-stage renal failure. With age, progressive damage to vital organ systems develops and at some point, organs may start to fail in functioning. End-stage renal disease and life-threatening cardiovascular or cerebrovascular complications limit life-expectancy of untreated males and females with reductions of 20 and 10 years, respectively, as compared to the general population. While there is increasing evidence that long-term enzyme therapy can halt disease progression, the importance of adjunctive therapies should be emphasized and the possibility of developing an oral therapy drives research forward into active site specific chaperones. © 2010 Germain; licensee BioMed Central Ltd.


Grant
Agency: European Commission | Branch: H2020 | Program: ERC-STG | Phase: ERC-StG-2014 | Award Amount: 1.49M | Year: 2015

The presence of organic compounds was essential to the emergence of life on Earth 3.5 to 3.8 billion years ago. Such compounds may have had several different origins; amongst them the ocean-atmosphere coupled system (the primordial soup theory), or exogenous inputs by meteorites, comets and Interplanetary Dust Particles. Titan, the largest moon of Saturn, is the best known observable analogue of the Early Earth. I recently identified a totally new source of prebiotic material for this system: the upper atmosphere. Nucleobases have been highlighted as components of the solid aerosols analogues produced in a reactor mimicking the chemistry that occurs in the upper atmosphere. The specificity of this external layer is that it receives harsh solar UV radiations enabling the chemical activation of molecular nitrogen N2, and involving a nitrogen rich organic chemistry with high prebiotic interest. As organic solid aerosols are initiated in the upper atmosphere of Titan, a new question is raised that I will address: what is the evolution of these organic prebiotic seeds when sedimenting down to the surface? Aerosols will indeed undergo the bombardment of charged particles, further UV radiation, and/or coating of condensable species at lower altitudes. I expect possible changes on the aerosols themselves, but also on the budget of the gas phase through emissions of new organic volatiles compounds. The aerosols aging may therefore impact the whole atmospheric system. An original methodology will be developed to address this novel issue. The successive aging sequences will be experimentally simulated in chemical reactors combining synchrotron and plasma sources. The interpretation of the experimental results will moreover be supported by a modelling of the processes. This complementary approach will enable to decipher the aerosols evolution in laboratory conditions and to extrapolate the impact on Titan atmospheric system.

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