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Burlington, VT, United States

The University of Vermont and State Agricultural College, more commonly known as the University of Vermont or UVM, is a public research university and, after 1862, the U.S. state of Vermont's land-grant university. The University of Vermont is labeled one of the original "Public Ivies," a publicly funded university considered as providing a quality of education comparable to those of the Ivy League.Founded in 1791, UVM is among the oldest universities in the United States and the fifth college established in New England after Harvard, Yale, Dartmouth and Brown.The university's 451-acre campus is located in Burlington. Features of the UVM campus include the historic University Green, the Dudley H. Davis Center—the first student center in the nation to receive U.S. Green Building Council LEED Gold certification—the Fleming Museum of Art, and the Gutterson/Patrick athletic complex, home to UVM's Division I athletic teams. The largest hospital complex in Vermont, The University of Vermont Medical Center, has its primary facility adjacent to the UVM campus and is affiliated with the UVM College of Medicine. Wikipedia.

Lewinter M.M.,University of Vermont
New England Journal of Medicine | Year: 2014

A previously healthy 25-year-old man presents with pleuritic pain in the left side of the chest of 3 hours' duration, radiating to the left trapezius ridge and relieved by sitting forward. On physical examination, he appears anxious. His pulse is 104 beats per minute and regular, his blood pressure is 125/80 mm Hg without a paradoxical pulse, and his temperature is 37.8°C. A three-component friction rub is auscultated along the left sternal border. An electrocardiogram (ECG) reveals ST-segment elevations in multiple leads, which are consistent with acute pericarditis. How should this case be managed?. Copyright © 2014 Massachusetts Medical Society.

Multidimensional complex optical potentials with partial parity-time (PT) symmetry are proposed. The usual PT symmetry requires that the potential is invariant under complex conjugation and simultaneous reflection in all spatial directions. However, we show that if the potential is only partially PT symmetric, i.e., it is invariant under complex conjugation and reflection in a single spatial direction, then it can also possess all-real spectra and continuous families of solitons. These results are established analytically and corroborated numerically. © 2014 Optical Society of America.

Merhi Z.,University of Vermont
Human Reproduction | Year: 2014

STUDY QUESTION: Do advanced glycation end products (AGEs) and their receptors play a role in female reproduction? SUMMARY ANSWER: AGEs might contribute to the etiology of polycystic ovary syndrome (PCOS) and infertility. WHAT IS KNOWN ALREADY: The endogenous AGEs are produced in the body by chemical reactions. Exogenous sources of AGEs are diet and smoking. AGEs have been proposed to be among the main intermediaries involved in several diseases, such as metabolic syndrome, type 2 diabetes mellitus, cardiovascular disease, ovarian aging, inflammation, neurodegenerative disorders and PCOS. STUDY DESIGN, SIZE, DURATION: A systematic review was performed for all available basic science and clinical peer-reviewed articles published in PubMed from 1987 to date. Abstracts of annual meetings of the Endocrine Society and American Society for Reproductive Medicine were also reviewed. PARTICIPANTS/ MATERIALS, SETTING, METHODS: A total of 275 publications and scientific abstracts were identified from the initial search. Sixty-two papers and four published scientific abstracts were selected for full review. The main outcomes were the regulatory effects of AGEs on: (i) granulosa cells, adipocyte physiology, obesity and insulin resistance in women with PCOS and in polycystic ovary animal models and (ii) infertility and measures of ovarian reserve. MAIN RESULTS AND THE ROLE OF CHANCE: There is an intricate relationship between the AGE-RAGE (receptor for AGEs) system and some aspects of PCOS, such as granulosa cell dysfunction, adipocyte pathophysiology, obesity and insulin resistance. Additionally, irregular ovarian AGE signaling might in part explain the abnormal ovarian histology observed in women with PCOS. The ovarian dysfunction due to AGEs in women without PCOS suggests a role for the AGE-RAGE system in the ovarian follicular environment, and might relate to assisted reproduction technology outcome and measures of ovarian reserve. LIMITATIONS, REASONS FOR CAUTION: The body of literature currently available limits these findings. The results obtained from granulosa cell lines and animal models may not fully extrapolate to humans. WIDER IMPLICATIONS OF THE FINDINGS: This review underscores a critical need to unveil the exact mechanistic actions of AGEs in reproductive physiology and more specifically the hypothalamic-pituitary-ovarian axis. AGE inhibitors might present an emerging therapeutic approach with significant applications in the context of PCOS and infertility. STUDY FUNDING/COMPETING INTEREST(S): American Society for Reproductive Medicine New Investigator Award and University of Vermont College of Medicine Internal Funds. No competing interests. © 2014 © The Author 2013.

Rincon M.,University of Vermont
Trends in Immunology | Year: 2012

The incidence and diversity of chronic inflammatory diseases is increasing worldwide. However, the complexity of clinical symptoms has made it difficult to develop therapies that provide a substantial improvement for extended periods of time in a wide range of patient groups. Thus, there is a need for new therapies that target inflammatory responses without compromising immune defense. Interleukin (IL)-6, one of the first identified cytokines, has recently been recognized as a potential target in inflammatory disease. Here, I discuss how this cytokine has evolved from being a marker of inflammation to a successful target to control inflammation. I will summarize the results from the recent clinical studies using IL-6 receptor blockade, and describe potential mechanisms by which IL-6 can contribute to the progression of inflammatory diseases. © 2012 Elsevier Ltd.

Wallace S.S.,University of Vermont
DNA Repair | Year: 2014

This perspective reviews the many dimensions of base excision repair from a 10,000 foot vantage point and provides one person's view on where the field is headed. Enzyme function is considered under the lens of X-ray diffraction and single molecule studies. Base excision repair in chromatin and telomeres, regulation of expression and the role of posttranslational modifications are also discussed in the context of enzyme activities, cellular localization and interacting partners. The specialized roles that base excision repair play in transcriptional activation by active demethylation and targeted oxidation as well as how base excision repair functions in the immune processes of somatic hypermutation and class switch recombination and its possible involvement in retroviral infection are also discussed. Finally the complexities of oxidative damage and its repair and its link to neurodegenerative disorders, as well as the role of base excision repair as a tumor suppressor are examined in the context of damage, repair and aging. By outlining the many base excision repair-related mysteries that have yet to be unraveled, hopefully this perspective will stimulate further interest in the field. © 2014 Elsevier B.V.

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