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Valencia, Spain

The University of Valencia is a university located in the Spanish city of Valencia. It is one of the oldest surviving universities in Spain, and the oldest in the Valencian Community, and is regarded as one of Spain's leading academic institutions. The University was founded in 1499, and currently has around 55,000 students. Most of the courses are given through the medium of Spanish, but the university has promised to increase the amount of courses available in Valencian. Moreover, in some degrees part of the teaching is in English.It is located in the Mediterranean Spanish baseline, in the city of Valencia which is the capital and most populous city of the autonomous community of Valencia and the third largest city in Spain, with a population of 810,064 in 2008. One of its campuses is located in the metropolitan area of Valencia, in the municipalities of Burjassot and Paterna.There are three campuses:The Burjassot Campus houses the colleges of Biology, Pharmacy, Physics, Chemistry, Mathematics and the School of Engineering.On the Blasco Ibañez Campus the Schools of Medicine and Dentistry, Philosophy and Educational science, Psychology, Geography and History, Languages, Physical Education, Physiotherapy and Nursing.The third campus, Tarongers, houses the Schools of Law, Economics and Business, Social science, and recently the School of Elementary Teacher Training, which moved from its previous location near the Blasco Ibañez Campus.The University is committed to keeping and establishing links with universities world-wide, either through bilateral agreements or by taking part in international programmes and networks. Thanks to international exchanges, students from different nationalities and cultures live and work together at the Universitat de València.The Strategic Plan of the University of Valencia 2008-2011 is oriented towards excellence in teaching, research and cultural diffusion to society.The current chancellor is Esteban Morcillo Sánchez. Wikipedia.

Canton E.,Hospital Universitario La Paz | Espinel-Ingroff A.,Virginia Commonwealth University | Peman J.,Hospital Universitario La Paz | Castillo L.D.,University of Valencia
Antimicrobial Agents and Chemotherapy | Year: 2010

Anidulafungin, micafungin, and caspofungin in vitro activities against Candida metapsilosis, C. orthopsilosis, and C. parapsilosis were evaluated by MICs and time-kill methods. All echinocandins showed lower MICs (mean MICs, 0.05 to 0.71 mg/liter) and the highest killing rates (-0.06 to -0.05 CFU/ml/h) for C. metapsilosis and C. orthopsilosis rather than for C. parapsilosis (mean MICs, 0.59 to 1.68 mg/liter). Micafungin and anidulafungin killing rates were greater than those determined for caspofungin. None of the echinocandins had fungicidal activity against C. parapsilosis. Copyright © 2010, American Society for Microbiology. All Rights Reserved. Source

Minakata H.,Tokyo Metroplitan University | Pena-Garay C.,University of Valencia
Advances in High Energy Physics | Year: 2012

We discuss constraints on the coefficient AMSW which is introduced to simulate the effect of weaker or stronger matter potential for electron neutrinos with the current and future solar neutrino data. The currently available solar neutrino data leads to a bound AMSW=1.47+0.54-0.42(+1.88-0.82) at 1σ (3σ) CL, which is consistent with the Standard Model prediction AMSW=1. For weaker matter potential (AMSW1), the constraint which comes from the flat 8B neutrino spectrum is already very tight, indicating the evidence for matter effects. However for stronger matter potential (AMSW>1), the bound is milder and is dominated by the day-night asymmetry of 8B neutrino flux recently observed by Super-Kamiokande. Among the list of observables of ongoing and future solar neutrino experiments, we find that (1) an improved precision of the day-night asymmetry of 8B neutrinos, (2) precision measurements of the low-energy quasi-monoenergetic neutrinos, and (3) the detection of the upturn of the 8B neutrino spectrum at low energies are the best choices to improve the bound on AMSW. © 2012 H. Minakata and C. Peña-Garay. Source

Alpiste-Illueca F.,University of Valencia
Medicina Oral, Patologia Oral y Cirugia Bucal | Year: 2012

Objetives: This study define altered passive eruption (APE) and evaluate the morphology of the dentogingival unit. Material and Methods: 123 individuals subjected to clinical examination and parallel profile radiography of the upper central incisor. An evaluation was made of the correlation between the clinical diagnosis of APE and the degree of gingival overlap; by using a 19% overlap to define APE (Kappa concordance index = 0.7). The Mann-Whitney / Wilcoxon test was used to identify the variables influencing APE. Results: Statistically significant differences were observed between the teeth with and without APE: gingival width (p = 0.0073), clinical crown length (p = 0.0000), smiling exposed gums (p = 0.0000), bone crest thickness (p = 0.0030), connective tissue attachment thickness (p = 0.0003) and biological width (p = 0.0015). Conclusions: The APE is characterized by: a gingival overlapping of over 19% of the length of the anatomical crown, increased gingival width and gingival smile; furthermore is associated to a thick bone crest and connective tissue attachment. Statistical analysis confirms two morphological patterns of APE. © Medicina Oral L. S. Source

Vento M.,University of Valencia
Journal of Neonatal-Perinatal Medicine | Year: 2010

Fetal to neonatal transition is characterized by an abrupt increase in the arterial partial pressure of oxygen and oxygen delivery to the tissue both causing a physiologic pro-oxidant status. Under normal circumstances arterial oxygen saturation measured by preductal pulse oximetry in term babies does not reach consistent values (85-90%) until four to five minutes after cord clamping, and 7 to 10 minutes in preterm infants. Of note, the time needed to stabilize saturation inversely correlates with gestational age. Oxygen in excess causes oxidative stress and inflammation in preterm infants. In order to avoid these negative consequences the inspiratory fraction of oxygen should be titrated until achievement of stable and safe oxygen saturation. Remarkably, the availability of an oxygen saturation nomogram could be of great help for the care givers. Supplementing the newborn with high inspiratory fractions of oxygen pursuing to rapidly achieve high oxygen saturation should be avoided. Instead, a proposal consisting in initiating resuscitation with lower oxygen inspiratory fractions and titrating according to targeted saturations is proposed. Multicenter international prospective randomized clinical trials powered to evaluate oxygen administration in the first minutes of life and neurodevelopment at two years are being launched at present and hopefully will clarify many of our doubts. © 2010 - IOS Press and the authors. All rights reserved. Source

Perea M.,University of Valencia | Gomez P.,DePaul University
PLoS ONE | Year: 2012

Background: Several recent studies have revealed that words presented with a small increase in interletter spacing are identified faster than words presented with the default interletter spacing (i.e., water faster than water). Modeling work has shown that this advantage occurs at an early encoding level. Given the implications of this finding for the ease of reading in the new digital era, here we examined whether the beneficial effect of small increases in interletter spacing can be generalized to a normal reading situation. Methodology: We conducted an experiment in which the participant's eyes were monitored when reading sentences varying in interletter spacing: i) sentences were presented with the default (0.0) interletter spacing; ii) sentences presented with a +1.0 interletter spacing; and iii) sentences presented with a +1.5 interletter spacing. Principal Findings: Results showed shorter fixation duration times as an inverse function of interletter spacing (i.e., fixation durations were briefest with +1.5 spacing and slowest with the default spacing). Conclusions: Subtle increases in interletter spacing facilitate the encoding of the fixated word during normal reading. Thus, interletter spacing is a parameter that may affect the ease of reading, and it could be adjustable in future implementations of e-book readers. © 2012 Perea, Gomez. Source

Egea J.A.,CSIC - Institute of Marine Research | Marti R.,University of Valencia | Banga J.R.,CSIC - Institute of Marine Research
Computers and Operations Research | Year: 2010

In this paper we present a new evolutionary method for complex-process optimization. It is partially based on the principles of the scatter search methodology, but it makes use of innovative strategies to be more effective in the context of complex-process optimization using a small number of tuning parameters. In particular, we introduce a new combination method based on path relinking, which considers a broader area around the population members than previous combination methods. We also use a population-update method which improves the balance between intensification and diversification. New strategies to intensify the search and to escape from suboptimal solutions are also presented. The application of the proposed evolutionary algorithm to different sets of both state-of-the-art continuous global optimization and complex-process optimization problems reveals that it is robust and efficient for the type of problems intended to solve, outperforming the results obtained with other methods found in the literature. © 2009 Elsevier Ltd. All rights reserved. Source

Yepes-Ramirez H.,University of Valencia
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | Year: 2011

ANTARES is a neutrino telescope located in the Mediterranean Sea with the aim of detecting high energy neutrinos of extra-terrestrial origin. It consists of a three dimensional array on 12 detection lines of photomultiplier tubes (PMTs) able to detect the Cherenkov light induced by muons produced in the interaction of neutrinos with the surrounding water and seabed. To reach the best angular resolution, good time and positioning calibrations are required. The propagation of Cherenkov photons strongly depends on the optical properties of the sea water, which has an impact on the reconstruction efficiency. The determination of the optical parameters, as the absorption and scattering lengths, is crucial to calculate properly the effective area and the angular resolution of the detector. The ANTARES optical beacon system consists of pulsed and fast, well controlled light sources distributed throughout the detector to carry out in situ the relative time calibration of the detector components. In this contribution we show some results on the sea water optical properties and their stability measured with the optical beacon system. © 2010 Elsevier B.V. All rights reserved. Source

De Valcarcel G.J.,University of Valencia | Staliunas K.,Polytechnic University of Catalonia
Physical Review Letters | Year: 2010

We propose a novel forcing technique of spatially extended self-oscillatory systems able to excite phase bistability and the dissipative structures associated with it. The forcing is time periodic at a frequency close to the oscillators' frequency and is spatially modulated. The effects of this type of forcing are demonstrated analytically and numerically in a directly driven complex Ginzburg-Landau equation. Both spatially periodic and spatially random drives prove to be effective. © 2010 The American Physical Society. Source

Domingo L.R.,University of Valencia | Perez P.,Andres Bello University
Physical Chemistry Chemical Physics | Year: 2014

ELF topological analysis of the ionic Diels-Alder (I-DA) reaction between the N,N-dimethyliminium cation and cyclopentadiene (Cp) has been performed in order to characterise the C-C single bond formation. The C-C bond formation begins in the short range of 2.00-1.96 Å via a C-to-C pseudoradical coupling between the most electrophilic center of the iminium cation and one of the two most nucleophilic centers of Cp. The electron density of the pseudoradical center generated at the most electrophilic carbon of the iminium cation comes mainly from the global charge transfer which takes place along the reaction. Analysis of the global reactivity indices indicates that the very high electrophilic character of the iminium cation is responsible for the negative activation energy found in the gas phase. On the other hand, the analysis of the radical Pok Parr functions of the iminium cation, and the nucleophilic P k - Parr functions of Cp makes the characterisation of the most favourable two-center interaction along the formation of the C-C single bond possible. This journal is © the Partner Organisations 2014. Source

Gonzalez M.A.,University of Valencia
European Journal of Medicinal Chemistry | Year: 2014

Naturally occurring aromatic abietane diterpenoids (dehydroabietanes) exhibit a wide range of biological activities. A number of synthetic studies aimed at modifying the abietane skeleton in order to obtain new potential chemotherapeutic agents have been reported. In this study, the biological activities of synthetic derivatives of aromatic abietane diterpenoids are reviewed. © 2014 Elsevier Masson SAS. Source

Domenech-Carbo A.,University of Valencia
Granular Matter | Year: 2016

It is examined the suitability of the modeling of impact events using friction and restitution as independent Doménech-Carbó (Granul Matter 16:573–582, 2014), including a modified description of collisions occurring in stick regime. The rebound of coins on a steel bar grooved at the nanoscopic scale was used to test the model combining surfaces with different asperities. The surface topography was examined by scanning tunneling microscopy and atomic force microscopy whereas the asperity was evaluated in terms of the fractal dimension of the surface determined from electrochemical impedance spectroscopy measurements. Experimental data denote that asperity variations determine significant variations in the coefficient of friction with no concomitant variations in the coefficient of tangential restitution. The meaning of the independence of restitution and friction as an operational approximation for simple modeling of collisions is discussed. © 2016, Springer-Verlag Berlin Heidelberg. Source

Spietelun A.,Technical University of Gdansk | Marcinkowski L.,Technical University of Gdansk | De La Guardia M.,University of Valencia | Namiesnik J.,Technical University of Gdansk
Talanta | Year: 2014

Determination of analytes at trace levels in complex samples (e.g. biological or contaminated water or soils) are often required for the environmental assessment and monitoring as well as for scientific research in the field of environmental pollution. A limited number of analytical techniques are sensitive enough for the direct determination of trace components in samples and, because of that, a preliminary step of the analyte isolation/enrichment prior to analysis is required in many cases. In this work the newest trends and innovations in liquid phase microextraction, like: single-drop microextraction (SDME), hollow fiber liquid-phase microextraction (HF-LPME), and dispersive liquid-liquid microextraction (DLLME) have been discussed, including their critical evaluation and possible application in analytical practice. The described modifications of extraction techniques deal with system miniaturization and/or automation, the use of ultrasound and physical agitation, and electrochemical methods. Particular attention was given to pro-ecological aspects therefore the possible use of novel, non-toxic extracting agents, inter alia, ionic liquids, coacervates, surfactant solutions and reverse micelles in the liquid phase microextraction techniques has been evaluated in depth. Also, new methodological solutions and the related instruments and devices for the efficient liquid phase micoextraction of analytes, which have found application at the stage of procedure prior to chromatographic determination, are presented. © 2013 Elsevier B.V. Source

Celis A.,University of Valencia
Nuclear and Particle Physics Proceedings | Year: 2015

In this talk I discuss the role of heavy quarks in new physics searches with tau leptons. I focus on new physics effects associated to the scalar sector which are naturally enhanced for the heaviest fermions due to the large hierarchy of the fermion masses. I will discuss two topics within this context: lepton flavour violation in the τ - ℓ (ℓ = e, μ) sector and violations of lepton universality in tauonic B decays. © 2015 Elsevier B.V. Source

Rubio S.J.,University of Valencia
Dynamic Games and Applications | Year: 2011

In this paper we model the case of an international non-renewable resource monopolist as a dynamic game between a monopolist and n importing countries governments, and investigate whether a tariff on resource imports can be advantageous for consumers in importing countries. We analyse both the case of a price-setting monopolist and the case of a quantity-setting monopolist. We find that a tariff is advantageous for consumers, even when there is no commitment to the trade policy and importing countries do not coordinate their policies. Using a numerical example, we find that a tariff is more advantageous for the importing countries if the monopolist chooses the quantity instead of the price and that the optimal temporal path when the monopolist chooses the price is consistently below the optimal temporal path when the monopolist chooses the quantity for the entire period of exploitation of the resource. Nevertheless, the variation in total welfare between the two regimens is small. © 2011 Springer Science+Business Media, LLC. Source

Nebot-Gil I.,University of Valencia
Journal of Chemical Theory and Computation | Year: 2015

On the basis of a dressed matrices formalism, a new algorithm has been devised for obtaining the lowest eigenvalue and the corresponding eigenvector of large real symmetric matrices. Given an N × N matrix, the proposed algorithm consists in the diagonalization of (N - 1)2 × 2 dressed matrices. Both sequential and parallel versions of the proposed algorithm have been implemented. Tests have been performed on a Hilbert matrix, and the results show that this algorithm is up 340 times faster than the corresponding LAPACK routine for N = 104 and about 10% faster than the Davidson method. The parallel MPI version has been tested using up to 512 nodes. The speed-up for a N = 106 matrix is fairly lineal until 64 cores. The time necessary to obtain the lowest eigenvalue and eigenvector is nearly 5.5 min with 512 cores. For an N = 107 matrix, the speed-up is nearly linear to 256 cores and the calculation time is 5.2 h with 512 nodes. Finally, in order to test the new algorithm on MRCI matrices, we have calculated the ground state and the π → π∗ excited state of the butadiene molecule, starting from both SCF and CASSCF wave functions. In all the cases considered, correlation energies and wave functions are the same as obtained with the Davidson algorithm. © 2014 American Chemical Society. Source

Makarenko A.N.,Tomsk State Pedagogical University | Odintsov S.D.,Catalan Institution for Research and Advanced Studies | Odintsov S.D.,Institute Of Ciencies Of L Espai Csic Ieec | Olmo G.J.,University of Valencia | Olmo G.J.,Federal University of Paraiba
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2014

We study late-time cosmic accelerating dynamics from Born-Infeld- f(R) gravity in a simplified conformal approach. We find that a variety of cosmic effects such as Little Rip, ΛCDM universe and dark energy cosmology with finite-time future singularities may occur. Unlike the convenient Born-Infeld gravity where in the absence of matter only de Sitter expansion may emerge, apparently any FRW cosmology maybe reconstructed from this conformal version of the Born-Infeld-f(R) theory. Despite the fact that the explicit form of f(R) is fixed by the conformal ansatz, the relation between the two metrics in this approach may be changed so as to bring out any desired FRW cosmology. © 2014 The Authors. Source

Vento M.,University of Valencia | Saugstad O.D.,University of Oslo
Seminars in Fetal and Neonatal Medicine | Year: 2010

Resuscitation is one of the most frequently performed procedures in the neonatal period. Since the most recent guidelines from the International Liaison Committee on Resuscitation (ILCOR) appeared in 2005, experimental and clinical research has introduced changes regarding the different components of the procedure, with the common denominator being the least aggressive to the baby. Babies should be kept warm, avoiding suctioning as a general rule, adjusting pressure, volume and oxygen to the minimum to achieve stabilisation without causing harm to the airways or oxidative stress, and applying all the available technology in the delivery room before transportation to the neonatal intensive care unit. The response to ventilation should primarily be assessed by the heart rate. Babies of gestational age ≥32 weeks should be ventilated initially with 21% oxygen and if <32 weeks with 21-30% oxygen. Intubation, chest compressions, use of drugs or volume therapy are rarely needed in term or near term babies in need of resuscitation. The first minutes of life are decisive, and what we do during these minutes will have unequivocal influence later on. © 2010 Elsevier Ltd. Source

Maiezza A.,University of Valencia | Nemevsek M.,Jozef Stefan Institute
Acta Physica Polonica B | Year: 2015

We discuss the scalar sector of the minimal Left-Right model, going through a comprehensive analysis of the relevant theoretical constraints on the parameter space from low energy processes and perturbativity. As a consequence, the anatomy of the Higgs boson(s) is drawn in the parametric space of the model, giving rise to a possible Lepton Number Violating (LNV) channel in the standard-like Higgs boson decay. The process could probe the origin of the neutrino masses and parity restoration at the LHC even beyond other direct searches. Source

Maiezza A.,University of Valencia | Nemevsek M.,Jozef Stefan Institute
Acta Physica Polonica B | Year: 2015

We discuss the possibility of probing the origin of neutrino mass at the LHC. To this end, we focus on processes mediated by the Higgs boson, in particular on its rare decay to a pair of heavy right-handed neutrinos. Probing the mass origin is possible when heavy neutrino mass is protected by an extended gauge symmetry, such as Left-Right symmetry. In this case, the Higgs triplet that provides the heavy neutrino mass mixes with the SM one. We discuss the collider features, relevant backgrounds and a set of selection criteria which enhance the sensitivity, including a cut on the heavy neutrino vertex displacement. Source

Erdozain A.,University of Navarra | Crespo P.M.,University of Navarra | Beferull-Lozano B.,University of Valencia
IEEE Transactions on Signal Processing | Year: 2012

The complexity and delay introduced by efficient digital coding strategies may be a barrier in some real-time communications. In this sense, these last years, joint source-channel coding schemes based on analog mappings have gained prominence precisely for their simplicity and their implicit low delay. In this work, analog mappings originally designed for point-to-point communications are adapted to the case of parallel channels by following the multiple description strategy traditionally used in source coding. In principle, the coding scheme is designed to transmit over parallel AWGN on-off channels, which are characterized by the possibility of having failures. We also show that our scheme performs satisfactorily over slow Rayleigh fading parallel channels. © 2012 IEEE. Source

Strandberg E.,Karlsruhe Institute of Technology | Esteban-Martin S.,Barcelona Institute for Research in Biomedicine | Ulrich A.S.,Karlsruhe Institute of Technology | Salgado J.,University of Valencia
Biochimica et Biophysica Acta - Biomembranes | Year: 2012

Hydrophobic mismatch still represents a puzzle for transmembrane peptides, despite the apparent simplicity of this concept and its demonstrated validity in natural membranes. Using a wealth of available experimental 2H NMR data, we provide here a comprehensive explanation of the orientation and dynamics of model peptides in lipid bilayers, which shows how they can adapt to membranes of different thickness. The orientational adjustment of transmembrane α-helices can be understood as the result of a competition between the thermodynamically unfavorable lipid repacking associated with peptide tilting and the optimization of peptide/membrane hydrophobic coupling. In the positive mismatch regime (long-peptide/thin-membrane) the helices adapt mainly via changing their tilt angle, as expected from simple geometrical predictions. However, the adaptation mechanism varies with the peptide sequence in the flanking regions, suggesting additional effects that modulate hydrophobic coupling. These originate from re-adjustments of the peptide hydrophobic length and they depend on the hydrophobicity of the flanking region, the strength of interfacial anchoring, the structural flexibility of anchoring side-chains and the presence of alternative anchoring residues. © 2012 Elsevier B.V. All rights reserved. Source

Estella C.,Columbia University | Estella C.,University of Valencia | Voutev R.,Columbia University | Mann R.S.,Columbia University
Current Topics in Developmental Biology | Year: 2012

Animal appendages require a proximodistal (PD) axis, which forms orthogonally from the two main body axes, anteroposterior and dorsoventral. In this review, we discuss recent advances that begin to provide insights into the molecular mechanisms controlling PD axis formation in the Drosophila leg. In this case, two morphogens, Wingless (Wg) and Decapentaplegic (Dpp), initiate a genetic cascade that, together with growth of the leg imaginal disc, establishes the PD axis. The analysis of cis-regulatory modules (CRMs) that control the expression of genes at different positions along the PD axis has been particularly valuable in dissecting this complex process. From these experiments, it appears that only one concentration of Wg and Dpp are required to initiate PD axis formation by inducing the expression of Distal-less (Dll), a homeodomain-encoding gene that is required for leg development. Once Dll is turned on, it activates the medially expressed gene dachshund (dac). Cross-regulation between Dll and dac, together with cell proliferation in the growing leg imaginal disc, results in the formation of a rudimentary PD axis. Wg and Dpp also initiate the expression of ligands for the EGFR pathway, which in turn induces the expression of a series of target genes that pattern the distal-most portion of the leg. © 2012 Elsevier Inc. Source

Domenech A.,University of Valencia
Analytical Methods | Year: 2011

Electrochemical techniques provide information of archaeometric interest. An overview on the application and future developments of the voltammetry of microparticles to the study of archaeological metals and their alteration products is presented. A report on the state of the art and future developments of this technique with regard to identification and origin studies of materials, authentication, chronology and dating of archaeological metal is provided. © 2011 The Royal Society of Chemistry. Source

We review the results from the use of various integrated nanophotonic sensors for label-free biosensing developed in three recent European biosensor collaborations: SABIO, INTOPSENS, and POSITIVE. Nanophotonic transducers are attractive for label-free biosensing due to their small footprint, high Q-factors, and compatibility with on-chip optics and microfluidics. This enables integrated sensor arrays for compact labs-on-chip. One application of label-free sensor arrays is for point-of-care medical diagnostics. Bringing such powerful tools to the single medical practitioner is an important step towards personalized medicine, but requires addressing a number of issues: improving limit of detection, managing the influence of temperature, parallelization of the measurement for higher throughput and on-chip referencing, efficient light-coupling strategies to simplify alignment, and packaging of the nanophotonics chip and integration with microfluidics. From SABIO, we report a volume sensing sensitivity of 240 nm/RIU and detection limit of 5 × 10 -6 RIU, and a surface sensing limit of detection (LOD) of 0.9 pg/mm 2 for at 1.3 μm for an eight-channel slot-waveguide ring resonator sensor array, within a microfluidics integrated compact cartridge. In INTOPSENS, ongoing efforts have so far resulted in various nanophotonic transducer designs with volume sensing sensitivities as great as 2,169 nm/RIU and LODs down to 8.3 × 10 -6 RIU at 1.5 μm. Early experiments from the POSITIVE project have demonstrated volumetric sensitivities as high as 1,247 nm/RIU at 1.5 μm. © 2011 Springer Science+Business Media, LLC. Source

Mitsou V.A.,University of Valencia
Journal of Physics: Conference Series | Year: 2015

R-parity violating supersymmetric models (RPV SUSY) are becoming increasingly more appealing than its R-parity conserving counterpart in view of the hitherto non-observation of SUSY signals at the LHC. In this paper, RPV scenarios where neutrino masses are naturally generated are discussed, namely RPV through bilinear terms (bRPV) and the "μ from ν" supersymmetric standard model (μνSSM). The latter is characterised by a rich Higgs sector that easily accommodates a 125-GeV Higgs boson. The phenomenology of such models at the LHC is reviewed, giving emphasis on final states with displaced objects, and relevant results obtained by LHC experiments are presented. The implications for dark matter for these theoretical proposals is also addressed. Source

Iocco F.,CNRS Paris Institute of Astrophysics | Taoso M.,University of Valencia | Leclercq F.,CNRS Paris Institute of Astrophysics | Leclercq F.,Ecole Polytechnique - Palaiseau | Meynet G.,University of Geneva
Physical Review Letters | Year: 2012

We study the effects of feebly or nonannihilating weakly interacting dark matter (DM) particles on stars that live in DM environments denser than that of our Sun. We find that the energy transport mechanism induced by DM particles can produce unusual conditions in the cores of main sequence stars, with effects which can potentially be used to probe DM properties. We find that solar mass stars placed in DM densities of ρ χ102GeV/cm3 are sensitive to spin-dependent scattering cross section σ SD10 -37cm2 and a DM particle mass as low as m χ=5GeV, accessing a parameter range weakly constrained by current direct detection experiments. © 2012 American Physical Society. Source

Fugas C.S.,University of Lisbon | Melia J.L.,University of Valencia | Silva S.A.,University of Lisbon
Journal of Occupational Health Psychology | Year: 2011

Despite a widespread view that social norms have an important contextual influence on health attitudes and behaviors, the impact of normative influences on safety behaviors has received very little attention. The current study proposes that supervisors' and coworkers' descriptive and injunctive safety norms influence proactive and compliance safety behaviors. Longitudinal results from 132 workers in a passenger transportation company support the link between coworkers' descriptive safety norms (at Time 1) and proactive safety practices (at Time 2). Crystallization of supervisor' injunctive safety norms (at Time 2) moderated the effect of coworkers' descriptive safety norms (at Time 1) on self-reported proactive safety behavior (at Time 2). These findings emphasize the differences between supervisors' and coworkers' descriptive and injunctive norms as sources of social influence on compliance and proactive safety behavior. © 2011 American Psychological Association. Source

Cerda A.,University of Valencia | Jurgensen M.F.,Michigan Technological University
Catena | Year: 2011

Ants are widely found in Mediterranean soils, where they increase water infiltration rates by forming soil macropores during nest construction. While higher water infiltration usually results in lower soil erosion rates, new soil brought to the surface by ant activity could increase sediments available for erosion. This could be especially important in intensively-managed citrus orchards, where surface mineral soil is exposed due to the lack of vegetation cover as a consequence of herbicide treatments. In the summer of 2009 rainfall simulations of low frequency-high intensity rainstorms were conducted in an orange orchard in eastern Spain on plots that contained ant nests and adjacent paired-plots without ant nests. Since soil erosion is a scale-dependent process, we used three plot sizes (0.25m2, 1m2, and 12m2) to determine the effect of ant burrowing and nesting on soil and water losses. Ant nests decreased water losses from 22.5% at 0.25m2 to 10.6% at 12m2, but soil erosion rates were nearly double in areas with ant activity (0.56 to 0.59Mgha-1h-1), as compared to soil with no ants (0.31 to 0.36Mgha-1h-1). Our results indicate that the presence of ants can increase soil erosion when rainfall intensity is greater than the infiltration capacity of the ant macropores. © 2011 Elsevier B.V. Source

Analysis of 1-octanol-water, cyclohexane-water and chloroform (CHCl(3))-water partition coefficients P(o-ch-cf) allows calculation of molecular lipophilicity patterns, which show that for a given atom log P(o-ch-cf) is sensitive to the presence of functional groups. Program CDHI does not properly differentiate between non-equivalent atoms. The most abundant single-wall carbon nanotube (SWNT), (10,10), presents a relatively small aqueous solubility and large elementary polarizability, P(o-ch-cf) and kinetic stability. The SWNT solubility is studied in various solvents, finding a class of non-hydrogen-bonding Lewis bases with good solubility. Solvents group into three classes. The SWNTs in some organic solvents are cationic while in water/Triton X mixture are anionic. Categorized solubility is semiquantitatively correlated with solvent parameters. The coefficient of term β is positive while the ones of ε and V negative. The electron affinity of d-glucopyranoses (d-Glcp(n)) suggests the formation of colloids of anionic SWNTs in water. Dipole moment for d-Glcp(n)-linear increases with n until four in agreement with 18-fold helix. The I(n)(z-) and SWNT(-) are proposed to form inclusion complexes with cyclodextrin (CD) and amylose (Amy). Starch, d-Glcp, CD and Amy are proposed as SWNT co-solvents. Guests-hosts are unperturbed. A central channel expansion is suggested. Source

Farre M.,CSIC - Institute of Environmental Assessment And Water Research | Pico Y.,University of Valencia | Barcelo D.,CSIC - Institute of Environmental Assessment And Water Research | Barcelo D.,University of Girona
Journal of Chromatography A | Year: 2014

The analysis of pesticides residues using a last generation high resolution and high mass accuracy hybrid linear ion trap-Orbitrap mass spectrometer (LTQ-Orbitrap-MS) was explored. Pesticides were extracted from fruits, fish, bees and sediments by QuEChERS and from water by solid-phase with Oasis HLB cartridges. Ultra-high pressure liquid chromatography (UHPLC)-LTQ-Orbitrap mass spectrometer acquired full scan MS data for quantification, and data dependent (dd) MS2 and MS3 product ion spectra for identification and/or confirmation. The regression coefficients (r2) for the calibration curves (two order of magnitude up to the lowest calibration level) in the study were ≥0.99. The LODs for 54 validated compounds were ≤2ngmL-1 (analytical standards). The relative standard deviation (RSD), which was used to estimate precision, was always lower than 22%. The recovery of extraction and matrix effects ranged from 58 to 120% and from -92 to 52%, respectively. Mass accuracy was always ≤4ppm, corresponding to a maximum mass error of 1.6millimass units (mmu). This procedure was then successfully applied to pesticide residues in a set of the above-mentioned food and environmental samples. In addition to target analytes, this method enables the simultaneous detection/identification of non-target pesticides, pharmaceuticals, drugs of abuse, mycotoxins, and their metabolites. © 2013 Elsevier B.V. Source

Domingo L.R.,University of Valencia | Emamian S.R.,Islamic Azad University at Shahrood
Tetrahedron | Year: 2014

Analysis of 12 three-atom-components (TACs) participating in [3+2] cycloaddition (32CA) reactions towards ethylene and acetylene allows establishing good correlations between the pseudodiradical character, the hardness η, and the nucleophilicity N index of the TAC with the feasibility of these non-polar reaction. These results allow the introduction of the pr index, which comprises the two aforementioned DFT reactivity indices. The increase of the pr index for an allylic-type TAC goes accompanied by a linear decrease of the activation enthalpy of the reaction. The present study makes it possible to establish a useful classification of 32CA reactions into zw-type reactions involving TACs with a high zwitterionic character, and pr-type reactions involving TACs with a high pseudodiradical character. © 2014 Elsevier Ltd. All rights reserved. Source

Esbrit P.,Institute Investigacion Sanitaria IIS | Esbrit P.,Institute Salud Carlos III | Alcaraz M.J.,Institute Salud Carlos III | Alcaraz M.J.,University of Valencia
Biochemical Pharmacology | Year: 2013

Osteoporosis is characterized by low bone mineral density and/or poor bone microarchitecture leading to an increased risk of fractures. The skeletal alterations in osteoporosis are a consequence of a relative deficit of bone formation compared to bone resorption. Osteoporosis therapies have mostly relied on antiresorptive drugs. An alternative therapeutic approach for osteoporosis is currently available, based on the intermittent administration of parathyroid hormone (PTH). Bone anabolism caused by PTH therapy is mainly accounted for by the ability of PTH to increase osteoblastogenesis and osteoblast survival. PTH and PTH-related protein (PTHrP)-an abundant local factor in bone- interact with the common PTH type 1 receptor with similar affinities in osteoblasts. Studies mainly in osteoporosis rodent models and limited data in postmenopausal women suggest that N-terminal PTHrP peptides might be considered a promising bone anabolic therapy. In addition, putative osteogenic actions of PTHrP might be ascribed not only to its N-terminal domain but also to its PTH-unrelated C-terminal region. In this review, we discuss the underlying cellular and molecular mechanisms of the anabolic actions of PTH and the similar potential of PTH-related protein (PTHrP) to increase bone mass and improve bone regeneration. © 2013 Elsevier Inc. All rights reserved. Source

Simon C.,University of Valencia
Handbook of Experimental Pharmacology | Year: 2010

Implantation is a complex process involving an intricate cascade of molecular interactions between the implanting blastocyst and the receptive endometrium. The molecular basis of endometrial receptivity and the mechanisms by which the blastocyst first adheres to the luminal epithelium and then penetrates into the stroma are only just beginning to be resolved. Advances in "omics" technologies, particularly proteomics and metabolomics, are set to have a major impact on the development of this field. In the wake of this information, novel targets for contraceptive intervention may become apparent. © 2010 Springer-Verlag Berlin Heidelberg. Source

Blanco A.M.,L.E.S.S. | Artero R.,University of Valencia
Methods | Year: 2010

Given the demand for improved methods for detecting and characterizing RNA variants in situ, we developed a quantitative method for detecting RNA alternative splicing variants that combines in situ hybridization of fluorescently labeled peptide nucleic acid (PNA) probes with confocal microscopy Förster resonance energy transfer (FRET). The use of PNA probes complementary to sequences flanking a given splice junction allows to specifically quantify, within the cell, the RNA isoform generating such splice junction as FRET efficiency measure. The FRET-based PNA fluorescence in situ hybridization (FP-FISH) method offers a conceptually new approach for characterizing at the subcellular level not only splice variant isoform structure, location, and dynamics but also potentially a wide variety of close range RNA-RNA interactions. In this paper, we explain the FP-FISH technique workflow for reliable and reproducible results. © 2010 Elsevier Inc. Source

Here are described 3 new species of Hieracium L. (Compositae, Lactuceae) collected on eastern of Spain. Source

Papoulias D.K.,University of Ioannina | Papoulias D.K.,University of Valencia | Kosmas T.S.,University of Ioannina
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2015

Tensorial non-standard neutrino interactions are studied through a combined analysis of nuclear structure calculations and a sensitivity χ2-type of neutrino events expected to be measured at the COHERENT experiment, recently planned to operate at the Spallation Neutron Source (Oak Ridge). Potential sizeable predictions on transition neutrino magnetic moments and other electromagnetic parameters, such as neutrino milli-charges, are also addressed. The non-standard neutrino-nucleus processes, explored from nuclear physics perspectives within the context of quasi-particle random phase approximation, are exploited in order to estimate the expected number of events originating from vector and tensor exotic interactions for the case of reactor neutrinos, studied with TEXONO and GEMMA neutrino detectors. © 2015 The Authors. Source

Campanario F.,University of Valencia | Figy T.M.,University of Manchester | Platzer S.,German Electron Synchrotron | Sjodahl M.,Lund University
Physical Review Letters | Year: 2013

We calculate next-to-leading order (NLO) QCD corrections to electroweak Higgs boson plus three jet production. Both vector boson fusion (VBF) and Higgs-strahlung type contributions are included along with all interferences. The calculation is implemented within the Matchbox NLO framework of the Herwig++ event generator. © 2013 American Physical Society. Source

Lopez-Lopez P.,University of Alicante | Benavent-Corai J.,University of Valencia | Garcia-Ripolles C.,University of Alicante | Urios V.,University of Alicante
PLoS ONE | Year: 2013

Background: Optimal foraging theory predicts that animals will tend to maximize foraging success by optimizing search strategies. However, how organisms detect sparsely distributed food resources remains an open question. When targets are sparse and unpredictably distributed, a Lévy strategy should maximize foraging success. By contrast, when resources are abundant and regularly distributed, simple Brownian random movement should be sufficient. Although very different groups of organisms exhibit Lévy motion, the shift from a Lévy to a Brownian search strategy has been suggested to depend on internal and external factors such as sex, prey density, or environmental context. However, animal response at the individual level has received little attention. Methodology/Principal Findings: We used GPS satellite-telemetry data of Egyptian vultures Neophron percnopterus to examine movement patterns at the individual level during consecutive years, with particular interest in the variations in foraging search patterns during the different periods of the annual cycle (i.e. breeding vs. non-breeding). Our results show that vultures followed a Brownian search strategy in their wintering sojourn in Africa, whereas they exhibited a more complex foraging search pattern at breeding grounds in Europe, including Lévy motion. Interestingly, our results showed that individuals shifted between search strategies within the same period of the annual cycle in successive years. Conclusions/Significance: Results could be primarily explained by the different environmental conditions in which foraging activities occur. However, the high degree of behavioural flexibility exhibited during the breeding period in contrast to the non-breeding period is challenging, suggesting that not only environmental conditions explain individuals' behaviour but also individuals' cognitive abilities (e.g., memory effects) could play an important role. Our results support the growing awareness about the role of behavioural flexibility at the individual level, adding new empirical evidence about how animals in general, and particularly scavengers, solve the problem of efficiently finding food resources. © 2013 López-López et al. Source

Resende M.G.C.,AT&T | Marti R.,University of Valencia | Gallego M.,Rey Juan Carlos University | Duarte A.,Rey Juan Carlos University
Computers and Operations Research | Year: 2010

The max-min diversity problem (MMDP) consists in selecting a subset of elements from a given set in such a way that the diversity among the selected elements is maximized. The problem is NP-hard and can be formulated as an integer linear program. Since the 1980s, several solution methods for this problem have been developed and applied to a variety of fields, particularly in the social and biological sciences. We propose a heuristic method-based on the GRASP and path relinking methodologies-for finding approximate solutions to this optimization problem. We explore different ways to hybridize GRASP and path relinking, including the recently proposed variant known as GRASP with evolutionary path relinking. Empirical results indicate that the proposed hybrid implementations compare favorably to previous metaheuristics, such as tabu search and simulated annealing. © 2008 Elsevier Ltd. All rights reserved. Source

Winskel H.,Southern Cross University of Australia | Perea M.,University of Valencia | Ratitamkul T.,Chulalongkorn University
Quarterly Journal of Experimental Psychology | Year: 2012

Previous research supports the view that initial letter position has a privileged role in comparison to internal letters for visual-word recognition in Roman script. The current study examines whether this is the case for Thai. Thai is an alphabetic script in which ordering of the letters does not necessarily correspond to the ordering of a word's phonemes. Furthermore, Thai does not normally have interword spaces. We examined whether the position of transposed letters (internal, e.g., porblem, vs. initial, e.g., rpoblem) within a word influences how readily those words are processed when interword spacing and demarcation of word boundaries (using alternatingbold text) is manipulated. The eye movements of 54 participants were recorded while they were reading sentences silently. There was no apparent difference in degree of disruption caused when reading initial and internal transposed-letter nonwords. These findings give support to the view that letter position encoding in Thai is relatively flexible and that actual identity of the letter is more critical than letter position. This flexible encoding strategy is in line with the characteristics of Thai-that is, the flexibility in the ordering of the letters and the lack of interword spaces, which creates a certain level of ambiguity in relation to the demarcation of word boundaries. These findings point to script-specific effects operating in letter encoding in visual-word recognition and reading. © 2012 Copyright The Experimental Psychology Society. Source

Perea M.,University of Valencia | Nakatani C.,RIKEN | van Leeuwen C.,RIKEN
Memory and Cognition | Year: 2011

One critical question for the front end of models of visual-word recognition and reading is whether the stage of letter position coding is purely orthographic or whether phonology is (to some degree) involved. To explore this issue, we conducted a silent reading experiment in Japanese Kana-a script in which orthography and phonology can be easily separated-using a technique that is highly sensitive to phonological effects (i.e., Rayner's (1975) boundary technique). Results showed shorter fixation times on the target word when the parafoveal preview was a transposed-mora nonword (a.ri.me.ka [Japanese Source]-a.me.ri.ka [Japanese Source]) than when the preview was a replacement-mora nonword (a.ka.ho. ka [Japanese Source] -a.me.ri.ka [Japanese Source]). More critically, fixation times on the target word were remarkably similar when the parafoveal preview was a transposed-consonant nonword (a.re.mi.ka [Japanese Source]-a.ri.me.ka [Japanese Source]) and when the parafoveal preview was an orthographic control nonword (a.ke.hi.ka [Japanese Source]-a.me.ri.ka [Japanese Source]). Thus, these findings offer strong support for the view that letter/mora position coding during silent reading is orthographic in nature. © Psychonomic Society, Inc. 2010. Source

Tuia D.,University of Lausanne | Camps-Valls G.,University of Valencia | Matasci G.,University of Lausanne | Kanevski M.,University of Lausanne
IEEE Transactions on Geoscience and Remote Sensing | Year: 2010

The increase in spatial and spectral resolution of the satellite sensors, along with the shortening of the time-revisiting periods, has provided high-quality data for remote sensing image classification. However, the high-dimensional feature space induced by using many heterogeneous information sources precludes the use of simple classifiers: thus, a proper feature selection is required for discarding irrelevant features and adapting the model to the specific problem. This paper proposes to classify the images and simultaneously to learn the relevant features in such high-dimensional scenarios. The proposed method is based on the automatic optimization of a linear combination of kernels dedicated to different meaningful sets of features. Such sets can be groups of bands, contextual or textural features, or bands acquired by different sensors. The combination of kernels is optimized through gradient descent on the support vector machine objective function. Even though the combination is linear, the ranked relevance takes into account the intrinsic nonlinearity of the data through kernels. Since a naive selection of the free parameters of the multiple-kernel method is computationally demanding, we propose an efficient model selection procedure based on the kernel alignment. The result is a weight (learned from the data) for each kernel where both relevant and meaningless image features automatically emerge after training the model. Experiments carried out in multi- and hyperspectral, contextual, and multisource remote sensing data classification confirm the capability of the method in ranking the relevant features and show the computational efficience of the proposed strategy. © 2006 IEEE. Source

Galvez J.,University of Valencia
Current computer-aided drug design | Year: 2010

The role of molecular topology (MT) in the design and selection of new drugs is discussed. After an overview of the different in silico molecular design current technologies, the QSAR analysis is dealt in detail with particular emphasis in the use of topological indices as molecular descriptors. The results of the application of MT in drug design and discovery are described and finally a possible explanation is given about some of the key reasons explaining it's the extraordinary performance. Source

Olmo G.J.,University of Valencia | Olmo G.J.,Federal University of Paraiba | Rubiera-Garcia D.,Federal University of Paraiba
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2015

We show that the effective brane-world and the loop quantum cosmology background expansion histories can be reproduced from a modified gravity perspective in terms of an f(R) gravity action plus a g(R) term non-minimally coupled with the matter Lagrangian. The reconstruction algorithm that we provide depends on a free function of the matter density that must be specified in each case and allows to obtain analytical solutions always. In the simplest cases, the function f(R) is quadratic in the Ricci scalar, R, whereas g(R) is linear. Our approach is compared with recent results in the literature. We show that working in the Palatini formalism there is no need to impose any constraint that keeps the equations second-order, which is a key requirement for the successful implementation of the reconstruction algorithm. © 2014 The Authors. Source

We investigated patterns of specificity of liver flukes (fam. Brachycladiidae) in a community of cetaceans from the western Mediterranean. The liver and pancreas of 103 striped dolphins, Stenella coeruleoalba, 18 Risso's dolphins, Grampus griseus, 14 bottlenose dolphins, Tursiops truncatus, 8 common dolphins, Delphinus delphis, and 5 long-finned pilot whales, Globicephala melas, were analysed for brachycladiid species. Two species were found: Oschmarinella rochebruni in striped dolphins (prevalence (P): 61.2%; mean intensity (MI) (95% CI): 34.2 (25.7-45.6)), and Brachycladium atlanticum in striped dolphins (P: 39.8%; MI: 7.1 (4.8-13.1)) and a single individual of common dolphin (P: 12.5%; intensity: 19), which represents a new host record. A molecular analysis using the internal transcribed spacer 2 (ITS2) region of the rDNA gene confirmed that specimens of B. atlanticum were conspecific regardless of host species. Available dietary data suggest that Risso's dolphins, bottlenose dolphins and long-finned pilot whales would contact rarely, if at all, the infective stages of O. rochebruni and B. atlanticum. Neither the prevalence nor the mean abundance of B. atlanticum differed significantly between striped and common dolphins, but a principal component analysis using seven morphometric variables indicated that specimens collected from the common dolphin were stunted. These worms also had fewer eggs compared with specimens typically found in striped dolphins, although the size of the eggs was similar in both host species. Dwarfism and low fecundity have typically been found in helminths infecting unusual host species, and might reflect the lower compatibility of B. atlanticum for common dolphins. In summary, both O. rochebruni and B. atlanticum appear to exhibit a narrow specificity for striped dolphins in the western Mediterranean. Source

Pich A.,University of Valencia
Journal of Physics: Conference Series | Year: 2014

Kaon decays are an important testing ground of the electroweak flavour theory. They can provide new signals of CP violation and, perhaps, a window into physics beyond the Standard Model. At the same time, they exhibit an interesting interplay of long-distance QCD effects in flavour-changing transitions. A brief overview is presented, focusing on a few selected topics of particular interest. A more detailed and comprehensive review can be found in Ref. [1]. © Published under licence by IOP Publishing Ltd. Source

Campanario F.,University of Valencia | Kerner M.,Karlsruhe Institute of Technology | Ninh L.D.,Karlsruhe Institute of Technology | Zeppenfeld D.,Karlsruhe Institute of Technology
Physical Review Letters | Year: 2013

We report on the calculation of W±Zjj production with leptonic decays at hadron-hadron colliders at next-to-leading order in QCD. These processes are important both to test the quartic gauge couplings of the standard model and because they constitute relevant backgrounds to beyond standard model physics searches. Our results show that the next-to-leading order corrections reduce significantly the scale uncertainties and have a nontrivial phase space dependence. © 2013 American Physical Society. Source

Jantzen B.,RWTH Aachen | Ruiz-Femenia P.,University of Valencia
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

We analyze the subleading nonresonant contributions to the e +e-→W+W-bb̄ cross section at energies near the top-antitop threshold. These correspond to next-to-next-to-leading-order (NNLO) corrections with respect to the leading-order resonant result. We show that these corrections produce 1/Ïμ endpoint singularities which precisely cancel the finite-width divergences arising in the resonant production of the W+W -bb̄ final state from on-shell decays of the top and antitop quarks at the same order. We also provide analytic results for the (m t/Λ) 2, (mt/Λ) and (mt/Λ) Lambda; terms that dominate the expansion in powers of (Λ/mt) of the complete set of NNLO nonresonant corrections, where Λ is a cut imposed on the invariant masses of the bW pairs that is neither too tight nor too loose (mtΓt Λ2). © 2013 American Physical Society. Source

Pich A.,University of Valencia
Acta Physica Polonica B | Year: 2016

The first LHC run has confirmed the Standard Model as the correct theory at the electroweak scale, and the existence of a Higgs-like particle associated with the spontaneous breaking of the electroweak gauge symmetry. This article overviews the present knowledge on the Higgs boson and discuss alternative scenarios of electroweak symmetry breaking which are already being constrained by the experimental data. Source

Lopez-Caballero J.,National Autonomous University of Mexico | Oceguera-Figueroa A.,National Autonomous University of Mexico | Oceguera-Figueroa A.,University of Valencia | Leon-Regagnon V.,National Autonomous University of Mexico
Molecular Ecology Resources | Year: 2013

Paragonimus mexicanus is the causal agent of human paragonimiasis in several countries of the Americas. It is considered to be the only species of the genus present in Mexico, where it is responsible for human infection. Through the investigation of P. mexicanus specimens from several places throughout Mexico, we provide morphological, molecular and geographical evidence that strongly suggests the presence of at least three species from this genus in Mexico. These results raise questions regarding the diagnosis, treatment, prophylaxis and control of human paragonimiasis in Mexico. We also provide a brief discussion regarding biodiversity inventories and the convenience of providing molecular and morphological information in biodiversity studies. © 2013 John Wiley & Sons Ltd. Source

Winskel H.,Southern Cross University of Australia | Perea M.,University of Valencia
Quarterly Journal of Experimental Psychology | Year: 2014

Thai offers a unique opportunity to investigate the role of lexical tone processing during visual-word recognition, as tone is explicitly expressed in its script. In order to investigate the contribution of tone at the orthographic/phonological level during the early stages of word processing in Thai, we conducted a masked priming experiment-using both lexical decision and word naming tasks. For a given target word (e.g.,2/, room), five priming conditions were created: (a) identity (e.g., 2/), (b) same initial consonant, but with a different tone marker (e.g., 1/), (c) different initial consonant, but with the same tone marker (e.g., 2/), (d) orthographic control (different initial consonant, different tone marker; e.g., 1/), and (e) same tone homophony, but with a different initial consonant and different tone marker (e.g., /th2/). Results of the critical comparisons revealed that segmental information (i.e., consonantal information) appears to be more important than tone information (i.e., tone marker) in the early stages of visual-word processing in alphabetic, tonal languages like Thai. Thus, these findings may help constrain models of visual-word recognition and reading in tonal languages. © 2013 © 2013 The Experimental Psychology Society. Source

Han X.-F.,Yantai University | Wang L.,Yantai University | Wang L.,University of Valencia | Yang J.M.,CAS Institute of Theoretical Physics | Yang J.M.,Tohoku University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2016

In this paper we simultaneously explain the excesses of the 750 GeV diphoton, muon g-2 and h→μτ in an extension of the two-Higgs-doublet model (2HDM) with additional vector-like fermions and a CP-odd scalar singlet (P) which is identified as the 750 GeV resonance. This 750 GeV resonance has a mixing with the CP-odd scalar (A) from a second scalar doublet, which leads to a coupling between P and the SM particles as well as a coupling between A and the vector-like fermions. Such mixing and couplings are strongly constrained by τ→μγ, muon g-2 and the 750 GeV diphoton data. We scan over the parameter space and find that such an extension can simultaneously account for the observed excesses of 750 GeV diphoton, muon g-2 and h→μτ. The 750 GeV resonance decays in exotic modes, such as P→hA, P→HZ, P→HA and P→W±H∓, and its width can be dozens of GeV and is sensitive to the mixing angle. © 2016 The Authors. Source

Llena Puy C.,University of Valencia
Minerva stomatologica | Year: 2010

AIM: The study analyzes the consumption of cariogenic foods in a population of children between 6 and 10 years old. METHODS: Transversal descriptive study on a sample of 369 children who first attended to the Department 9 Dentistry dental office of the Valencia Region Health Agency (Spain). A self-administered food consumption frequency questionnaire was used to evaluate how often the food on the list were consumed by the children. RESULTS: Sticky sugar-rich foods, sugared milk and dairy products, food containing starch and sugar, sugary liquids and food with semihydrolyzed starch were consumed by over 50% of the sample at main meals and between meals. The mean intake of all these food groups, was over five times a week. The older children ate more fruit and foods rich in semihydrolyzed starch at main meals. Sweetened medication significantly reduced with age. Sugar-free sweets were consumed by almost 60% of the sample. CONCLUSION: The study shows a high intake of food with cariogenic potential, in particular processed food with added sugar and food with semihydrolyzed starch consumed between meals. This situation indicates the need to include health education programs in our population focused to improve the dietary habits of children and teenagers. Source

Poquet J.M.,University of Granada | Mesquita-Joanes F.,University of Valencia
Freshwater Biology | Year: 2011

1. The relationship between altitudinal gradients on small spatial scales and latitudinal gradients on broader scales has been repeatedly recognised in the biogeography of animals and plants. However, little is known about this topic in the ecology and biogeography of ostracod communities in Mediterranean flowing waters or the factors underlying these spatial patterns. 2. We analysed the ostracod assemblages of near-natural headwater streams in the Betic and Pre-Betic Mountains in the southern Iberian Peninsula to decipher the most important environmental gradients structuring ostracod communities on a local scale. In addition, the European altitudinal and latitudinal distributions of the most commonly found species were analysed with GIS and regression models to compare geographical effects from local to continental scales. 3. Forty sampling sites, distributed among six catchments and ranging in altitude between 150 and 1940m a.s.l., were sampled seasonally. Limnological and geographical information was also recorded for each sample. Seventeen ostracod species were found, two of which were new findings for the Iberian Peninsula: Potamocypris fulva and Cypria reptans. The most common species were Potamocypris zschokkei, Candona neglecta, Herpetocypris brevicaudata, Cyclocypris ovum, Potamocypris villosa and Pseudocandona albicans. The distribution of these species in 918 European locations was analysed to test the hypothesised change in altitudinal distribution with varying latitude. 4. The best subset of logistic and linear regression models, selected by means of the information-theoretic approach, found that oxygen content and the variables related with substratum and discharge were the most important variables with a negative influence on ostracod presence, abundance and species richness on a local scale. These findings suggest that the negative effect on benthic invertebrates of physical disturbances relates to high flow velocity and turbulences. 5. Multivariate ordination methods show how altitude and water chemistry are the most important variables to explain the distribution of ostracod assemblages on the small spatial scale. On a larger scale, differences in latitudinal distribution throughout Europe were significant for the six most common species found in Granada. In addition, four of these showed significant negative linear relationships between latitude and altitude in Europe, supporting the important effect of climate on local and continental scale distributions. While ostracod biogeographies are still poorly known, our results indicate the influence of Quaternary climate variability on ostracod dynamic colonisation and extinction in Europe in accordance with species-specific temperature and water chemistry preferences. © 2010 Blackwell Publishing Ltd. Source

Martinez-Lillo J.,University of Valencia
Polyhedron | Year: 2014

A novel rhenium(IV)-rhenium(V) compound of formula NBu4[Re VO2(py)4][ReIVBr6] (1) (NBu4 + = tetra-n-butylammonium cation and py = pyridine) has been prepared and characterized. The crystal structure of 1 was determined by single crystal X-ray diffraction. 1 crystallizes in the monoclinic system with space group Cc. The rhenium(IV) ion is six-coordinate by six Br atoms [average value of the ReIV-Br bonds lengths being ca. 2.509(1) Å], while rhenium(V) ion is six-coordinate by two axial oxo groups and four N atoms from four pyridine ligands [average values of the ReVO and ReV-N bonds lengths being ca. 1.77 and ca. 2.14 Å, respectively]. The magnetic properties were investigated from susceptibility measurements performed on a polycrystalline sample of 1. Its magnetic behavior is that of a magnetically diluted Re(IV) complex and is interpreted in terms of magnetically isolated spin quartets with a high value of the zero-field splitting (|2D| is ca. 8.6 cm-1). © 2013 Elsevier Ltd. All rights reserved. Source

Han X.-F.,Yantai University | Wang L.,Yantai University | Wang L.,University of Valencia | Wu L.,University of Sydney | And 3 more authors.
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2016

In this paper, we interpret the 750 GeV diphoton excess in the Zee-Babu extension of the two-Higgs-doublet model by introducing a top partner (T)/bottom partner (B). In the alignment limit, the 750 GeV resonance is identified as the heavy CP-even Higgs boson (H), which can be sizably produced via the QCD process pp→TT- or pp→BB- followed by the decay T→. Ht or B→. Hb. The diphoton decay rate of H is greatly enhanced by the charged singlet scalars predicted in the Zee-Babu extension and the total width of H can be as large as 7 GeV. Under the current LHC constraints, we scan the parameter space and find that such an extension can account for the observed diphoton excess. © 2016 The Authors. Source

Ferrando A.,University of Valencia | Milian C.,Ecole Polytechnique - Palaiseau | Skryabin D.V.,University of Bath
Journal of the Optical Society of America B: Optical Physics | Year: 2013

We present a first-principles derivation of the variational equations describing the dynamics of the interaction of a spatial soliton and a surface plasmon polariton (SPP) propagating along a metal/dielectric interface. The variational ansatz is based on the existence of solutions exhibiting differentiated and spatially resolvable localized soliton and SPP components. These solutions, referred to as soliplasmons, can be physically understood as bound states of a soliton and an SPP, which dispersion relations intersect, allowing resonant interaction between them [Phys. Rev. A 79, 041803 (2009)]. The existence of soliplasmon states and their interesting nonlinear resonant behavior has been validated already by full-vector simulations of the nonlinear Maxwell's equations, as reported in [Opt. Lett. 37, 4221 (2012)]. Here, we provide the theoretical analysis of the nonlinear oscillator model introduced in our previous work and present its rigorous derivation. We also provide some extensions of the model to improve its applicability. © 2013 Optical Society of America. Source

Desyatnikov A.S.,Australian National University | Dennis M.R.,University of Bristol | Ferrando A.,University of Valencia
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2011

We introduce discrete vortex solitons and vortex breathers in circular arrays of nonlinear waveguides. The simplest vortex breather in a four-waveguide coupler is a nonlinear dynamic state changing its topological charge between +1 and -1 periodically during propagation. We find the stability domain for this solution and suggest an all-optical vortex switching scheme. © 2011 American Physical Society. Source

Alpiste-Illueca F.,University of Valencia
Medicina Oral, Patologia Oral y Cirugia Bucal | Year: 2011

Gummy smile constitutes a relatively frequent aesthetic alteration characterized by excessive exhibition of the gums during smiling movements of the upper lip. It is the result of an inadequate relation between the lower edge of the upper lip, the positioning of the anterosuperior teeth, the location of the upper jaw, and the gingival margin position with respect to the dental crown. Altered Passive Eruption (APE) is a clinical situation produced by excessive gum overlapping over the enamel limits, resulting in a short clinical crown appearance, that gives the sensation of hidden teeth. The term itself suggests the causal mechanism, i.e., failure in the passive phase of dental eruption, though there is no scientific evidence to support this. While there are some authors who consider APE to be a risk situation for periodontal health, its clearest clinical implication refers to oral esthetics. APE is a factor that frequently contributes to the presence of a gummy or gingival smile, and it can easily be corrected by periodontal surgery. Nevertheless, it is essential to establish a correct differential diagnosis and good treatment plan. A literature review is presented of the dental eruption process, etiological hypotheses of APE, its morphologic classification, and its clinical relevance. © Medicina Oral S. L. Source

Cantero A.L.P.,University of Valencia
Zootaxa | Year: 2014

A revision of the known Antarctic species of the genus Halecium has been carried out, based on the study of both type and non-type material. For each species a list of synonyms, a diagnosis, a broad description (with the exception of the recently described H. frigidum and H. exaggeratum), a discussion of its relationship with other members of the genus, and an account of its autecological data are given. Thirteen Antarctic species of the genus, including H. pseudodelicatulum sp. nov. and H. pseudoincertus sp. nov., are considered valid. Halecium tubatum is considered as species inquirenda. Halecium ovatum and H. macrocaulus are considered to be junior synonyms of H. interpolatum and H. incertus, respectively. The presence of H. delicatulum and H. tenellum in Antarctic waters is questioned. All Antarctic records found in the literature have been checked. The cnidome proved to be a useful tool for species identification in some cases. Finally, a general survey of the geographical and bathymetric distribution of the species is presented. © 2014 Magnolia Press. Source

Stefanis N.G.,Ruhr University Bochum | Bakulev A.P.,Joint Institute for Nuclear Research | Mikhailov S.V.,Joint Institute for Nuclear Research | Pimikov A.V.,University of Valencia
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

A state-of-the-art analysis of the pion-photon transition form factor is presented based on an improved theoretical calculation that includes the effect of a finite virtuality of the quasireal photon in the method of light-cone sum rules. We carry out a detailed statistical analysis of the existing experimental data using this method and by employing pion distribution amplitudes with up to three Gegenbauer coefficients a2, a4, a6. Allowing for an error range in the coefficient a6≈0, the theoretical predictions for γ*γ→π0 obtained with nonlocal QCD sum rules are found to be in good agreement with all data that support a scaling behavior of the transition form factor at higher Q2, like those of the Belle Collaboration. The data on γ *γ→η/η′ from CLEO and BABAR are also reproduced, while there is a strong conflict with the auxetic trend of the BABAR data above 10 GeV2. The broader implications of these findings are discussed. © 2013 American Physical Society. Source

Chattaraj P.K.,Indian Institute of Technology Kharagpur | Duley S.,Indian Institute of Technology Kharagpur | Domingo L.R.,University of Valencia
Organic and Biomolecular Chemistry | Year: 2012

A local reactivity difference index Rk is shown to be able to predict the local electrophilic and/or nucleophilic activation within an organic molecule. Together with the electrophilic and/or nucleophilic behavior of the center k given by the sign, the magnitude of the Rk index accounts for the extent of the electronic activation, a behavior that allows for the use of the Rk index as a measure of the molecular reactivity especially in polar processes. © The Royal Society of Chemistry 2012. Source

Ratle F.,Nuance Communications | Camps-Valls G.,University of Valencia | Weston J.,Google
IEEE Transactions on Geoscience and Remote Sensing | Year: 2010

A framework for semisupervised remote sensing image classification based on neural networks is presented. The methodology consists of adding a flexible embedding regularizer to the loss function used for training neural networks. Training is done using stochastic gradient descent with additional balancing constraints to avoid falling into local minima. The method constitutes a generalization of both supervised and unsupervised methods and can handle millions of unlabeled samples. Therefore, the proposed approach gives rise to an operational classifier, as opposed to previously presented transductive or Laplacian support vector machines (TSVM or LapSVM, respectively). The proposed methodology constitutes a general framework for building computationally efficient semisupervised methods. The method is compared with LapSVM and TSVM in semisupervised scenarios, to SVM in supervised settings, and to online and batch k-means for unsupervised learning. Results demonstrate the improved classification accuracy and scalability of this approach on several hyperspectral image classification problems. © 2010 IEEE. Source

Rios J.-L.,University of Valencia
Planta Medica | Year: 2011

Poria cocos (Polyporaceae) is a saprophytic fungus that grows in diverse species of Pinus. Its sclerotium, called fu-ling or hoelen, is used in traditional Chinese and Japanese medicine for its diuretic, sedative, and tonic effects. Various studies of this fungus have demonstrated its marked anti-inflammatory activity in different experimental models of acute and chronic inflammation. It is widely used as a constituent of many preparations in Asian medicine, but the number of research papers on its clinical properties is insufficient for establishing its efficacy and safety from a scientific point of view. In this review, we have compiled all the published data concerning the chemistry, pharmacology, and clinical uses of this drug in order to evaluate its clinical interest for future use against various pathologies in which inflammation and immunodepression are implicated. We selected the papers for review on the basis of their ethnopharmacological relevance, using the most relevant databases for the biomedical sciences. Studies on various fungus extracts as well as on the major phytochemical compounds (polysaccharides and triterpenoids) present in Poria cocos comprised the principal objectives of this review. In several of the studies reviewed, the inhibitory effects of triterpenes on phospholipase A(PLA have been clearly demonstrated. In addition, the inhibitory effects of Poria cocos on the secretion of different cytokines from human peripheral blood monocytes have also been described. Triterpenoids are known to have a pivotal influence on certain diseases such as rheumatoid arthritis, psoriasis, autoimmune uveitis, septic shock, and possibly bronchial asthma, while polysaccharides can potentiate the immune response. Reviewing the literature, we found that polysaccharides from Poria cocos enhanced the secretion of immune stimulators and suppressed the secretion of immune suppressors, thus potentiating the immune response. In addition, they showed antitumor activity against different cancer cell lines. This activity is associated with their capacity to inhibit angiogenesis by downregulating both NF-B and the induction of NF-B/Rel translocation. © Georg Thieme Verlag KG Stuttgart · New York. Source

Camps-Valls G.,University of Valencia | Shervashidze N.,Max Planck Institutes | Borgwardt K.M.,Max Planck Institutes
IEEE Geoscience and Remote Sensing Letters | Year: 2010

This letter presents a graph kernel for spatio-spectral remote sensing image classification with support vector machines (SVMs). The method considers higher order relations in the neighborhood (beyond pairwise spatial relations) to iteratively compute a kernel matrix for SVM learning. The proposed kernel is easy to compute and constitutes a powerful alternative to existing approaches. The capabilities of the method are illustrated in several multi- and hyperspectral remote sensing images acquired over both urban and agricultural areas. © 2006 IEEE. Source

Dolatabadi J.E.N.,Tabriz University of Medical Sciences | de la Guardia M.,University of Valencia
TrAC - Trends in Analytical Chemistry | Year: 2011

Diatoms, single-cell eukaryotic microalgae, are present in nearly every water habitat and their silicon-dioxide (silica)-based cell walls of tens to hundreds of micrometers in size are the most interesting feature to be used in nanotechnology, including biosensing, drug delivery, molecular separation, molecular biology, biomimetics, frustule formation, and electronic, photonic, optical and structural materials. In this review, we present recent progress in applications of diatoms and silica nanomaterials in biosensing, drug and gene delivery, and formation of complex metal nanostructures. © 2011 Elsevier Ltd. Source

Barenboim G.,University of Valencia | Chun E.J.,Korea Institute for Advanced Study | Lee H.M.,Chung - Ang University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2014

We revisit a single field inflationary model based on Coleman-Weinberg potentials. We show that in small field Coleman-Weinberg inflation, the observed amplitude of perturbations needs an extremely small quartic coupling of the inflaton, which might be a signature of radiative origin. However, the spectral index obtained in a standard cosmological scenario turns out to be outside the 2. σ region of the Planck data. When a non-standard cosmological framework is invoked, such as brane-world cosmology in the Randall-Sundrum model, the spectral index can be made consistent with Planck data within 1. σ, courtesy of the modification in the evolution of the Hubble parameter in such a scheme. We also show that the required inflaton quartic coupling as well as a phenomenologically viable B - L symmetry breaking together with a natural electroweak symmetry breaking can arise dynamically in a generalized B - L extension of the Standard Model where the full potential is assumed to vanish at a high scale. © 2014 The Authors. Source

The assimilation model describes therapeutic change through APES (Assimilation of Problematic Experiences Scale) trying to reconcile the study of change through a pre-/post-test comparison with studying moment-by-moment change. Two processes of assimilation are described and compared from two clinical cases treated with the linguistic therapy of evaluation. A sample of 2,211 passages was coded with the APES. The good outcome case showed, at the end of treatment and at different moments of the therapeutic process, high stages of assimilation in its four problematic experiences. The poor outcome case showed, at the end of treatment and at different moments of the therapeutic process, the assimilation of some of its five problematic experiences. In both cases, the assimilation pattern was sawtoothed, with jumps and returns between APES stages. Source

Mahmoodabadi M.,Shahid Bahonar University of Kerman | Cerda A.,University of Valencia
Geoderma | Year: 2013

Modeling soil erosion contributes to the understanding of the erosion processes and needs to predict accurately the erosion rates under different environmental conditions. Few studies have investigated the WEPP's applicability for arid and semi-arid conditions that differ from those where the model was developed. This research was carried out to evaluate and improve the WEPP model for arid and semiarid regions for interrill erosion using a rainfall simulator at plot scale. The results showed that measured interrill erosion rates ranged from 9.3×10-6 to 89.6×10-6kgm-2s-1. In comparison, the WEPP-interrill erosion prediction values were on average 14.5 times lower than the measured ones, which can be ascribed to a systematic error. To calibrate the model, two regression equations were presented to estimate baseline interrill erodibility (Kib) and adjusted interrill erodibility (Kiadj). Accordingly, the baseline interrill erodibility was influenced by surface rock cover much more than any other soil property. Also, Kiadj was functioned as sediment concentration and sand percent. Model validation showed that after calibrating Kib and Kiadj, the coefficient of efficiency enhanced to 0.31 and 0.90, respectively. However, the model tended to overestimate the lower erosion rates and to underestimate the higher erosion rates. To modify interrill erodibility and to achieve a process-based parameter, a simple equation was developed based on stream power. The coefficient of efficiency of 0.61 was obtained for the proposed approach. In general, the model predictions enhanced after calibration, but the model tendency to underestimate high erosion rates was observed. One of the reasons for low accuracy of the WEPP was its dependence on soil empirical parameters used in predicting the sub-model components. The model prediction was found to be improved through process-based calibration of soil parameters. © 2013 Elsevier B.V. Source

Costa H.,University of Valencia
The Spanish journal of psychology | Year: 2013

The present paper examined the role of perceived emotional intelligence-EI- (measured by adaptations of the Trait Meta-Mood Scale - TMMS, Salovey, Mayer, Goldman, Turvey, & Palfai, 1995) as a predictor of life satisfaction and mental health. We explored the unique contribution of EI dimensions (Attention, Clarity and Repair) on individuals' psychological well-being, after controlling for the influence of general self-efficacy and socio-demographic variables (age, gender and culture). Data was collected from a sample of 1078 Spanish, Mexican, Portuguese and Brazilian undergraduate students (M(age) = 22.98; SD = 6.73) and analyzed using hierarchical multiple regressions. Results indicated that overall EI dimensions (especially Clarity and Repair) accounted for unique variance on psychological well-being above and beyond general self-efficacy and socio-demographic characteristics. These findings provide additional support for the validity of perceived EI, and suggests that EI components contribute to important well-being criteria independently from well-known constructs such as self-efficacy. Source

Reinoso S.,University of Valencia | Galan-Mascaros J.R.,Institute of Chemical Research of Catalonia
Inorganic Chemistry | Year: 2010

Polyanion [{Ce(H2O)2}2Mn 2(B-α-GeW9O342]8- (1) constitutes the first example of a heterometallic 3d-4f cluster related to the Weakley-type dimeric structure, and it contains an unprecedented Ce 2IIIMn2IIIO20 rhomblike moiety displaying dominant CeIII-MnIII ferromagnetic interactions. © 2009 American Chemical Society. Source

Arcoya D.,University of Granada | Segura De Leon S.,University of Valencia
ESAIM - Control, Optimisation and Calculus of Variations | Year: 2010

We study a comparison principle and uniqueness of positive solutions for the homogeneous Dirichlet boundary value problem associated to quasi-linear elliptic equations with lower order terms. A model example is given by -Δ u+λ|∇u|2/ur = f(x), λ, r>0. The main feature of these equations consists in having a quadratic gradient term in which singularities are allowed. The arguments employed here also work to deal with equations having lack of ellipticity or some dependence on u in the right hand side. Furthermore, they could be applied to obtain uniqueness results for nonlinear equations having the p-Laplacian operator as the principal part. Our results improve those already known, even if the gradient term is not singular. © EDP Sciences, SMAI, 2008. Source

Reichardt C.L.,University of California at Berkeley | De Putter R.,University of Valencia | De Putter R.,University of Barcelona | Zahn O.,University of California at Berkeley | Hou Z.,University of California at Davis
Astrophysical Journal Letters | Year: 2012

We present new limits on early dark energy (EDE) from the cosmic microwave background (CMB) using data from the Wilkinson Microwave Anisotropy Probe (WMAP) satellite on large angular scales and South Pole Telescope on small angular scales. We find a strong upper limit on the EDE density of Ωe < 0.018 at 95% confidence, a factor of three improvement over WMAP data alone. We show that adding lower-redshift probes of the expansion rate to the CMB data improves constraints on the dark energy equation of state, but not the EDE density. We also explain how small-scale CMB temperature anisotropy constrains EDE. © 2012. The American Astronomical Society. All rights reserved. Source

Gao C.,Chinese University of Hong Kong | Cai Y.,Chinese University of Hong Kong | Wang Y.,University of Saskatchewan | Kang B.-H.,University of Florida | And 3 more authors.
Trends in Plant Science | Year: 2014

Unless there are mechanisms to selectively retain membrane proteins in the endoplasmic reticulum (ER) or in the Golgi apparatus, they automatically proceed downstream to the plasma or vacuole membranes. Two types of coat protein complex I (COPI)-interacting motifs in the cytosolic tails of membrane proteins seem to facilitate membrane retention in the early secretory pathway of plants: a dilysine (KKXX) motif (which is typical of p24 proteins) for the ER and a KXE/D motif (which occurs in the Arabidopsis endomembrane protein EMP12) for the Golgi apparatus. The KXE/D motif is highly conserved in all eukaryotic EMPs and is additionally present in hundreds of other proteins of unknown subcellular localization and function. This novel signal may represent a new general mechanism for Golgi targeting and the retention of polytopic integral membrane proteins. © 2014 Elsevier Ltd. Source

Gomez P.,DePaul University | Perea M.,University of Valencia
Quarterly Journal of Experimental Psychology | Year: 2014

In a diffusion model, performance as measured by latency and accuracy in two-choice tasks is decomposed into different parameters that can be linked to underlying cognitive processes. Although the diffusion model has been utilized to account for lexical decision data, the effects of stimulus manipulations in previous experiments originated from just one parameter: the quality of the evidence. Here we examined whether the diffusion model can be used to effectively decompose the underlying processes during visual-word recognition. We explore this issue in an experiment that features a lexical manipulation (word frequency) that we expected to affect mostly the quality of the evidence (the drift rate parameter), and a perceptual manipulation (stimulus orientation) that presumably affects the nondecisional time (the Ter parameter, time of encoding and response) more than it affects the drift rate. Results showed that although the manipulations do not affect only one parameter, word frequency and stimulus orientation had differential effects on the model's parameters. Thus, the diffusion model is a useful tool to decompose the effects of stimulus manipulations in visual-word recognition. © 2014 The Experimental Psychology Society. Source

Sanchis-Gomar F.,University of Valencia
Journal of Cellular Physiology | Year: 2013

Oxidative stress results from damage to tissues caused by free radicals and is increased by exercise. Peroxiredoxins (PRXs) maintain the cellular reducing environment by scavenging intracellular hydrogen peroxide. It has been recently noted that physical exercise has a positive effect on the PRX system, exerting a protective effect against oxidative stress-induced damage. However, other compounds, such as sestrins (SESNs), a stress-inducible protein family with antioxidant properties, should also be considered in the function of PRXs. SESNs are clearly involved in the regeneration process of PRXs and therefore may also be modulated by physical exercise. In addition, SESNs are clearly involved in TOR, AMPK, p53, FoxO, and PRXs signaling pathways. The aforementioned pathways are implicated in aging processes by inducing an increased resistance to subsequent stress, thus delaying age-related changes, such as sarcopenia and frailty, and consequently promoting longevity. Likewise, exercise also modulates these pathways. In fact, exercise is one of the most important recommended strategies to prevent sarcopenia and frailty, increase longevity, and improve health in the elderly. Loss of SESNs can cause several chronic pathologies, such as fat accumulation, mitochondrial dysfunction, cardiac arrhythmia, and/or muscle degeneration. Accordingly, physical inactivity leads to accumulation of visceral fat and consequently the activation of a network of inflammatory pathways, which promote development of insulin resistance, atherosclerosis, neurodegeneration, and tumor growth. To date, the SESNs-exercise relationship has not been explored. However, this emerging family of stress proteins may be part of the redox-based adaptive response to exercise. © 2013 Wiley Periodicals, Inc. Source

Sanchez-Zuriaga D.,University of Valencia | Adams M.A.,University of Bristol | Dolan P.,University of Bristol
Spine | Year: 2010

Study Design: Intervention study on healthy human subjects. Objective: To determine whether reflex activation of the back muscles is influenced by muscle fatigue or soft tissue creep in the spine. Summary of Background Data: Reflex contraction of the back muscles normally acts to limit spinal flexion, and hence protect the underlying spine from injury. However, repeated flexion allows bending moments on the spine to increase. Impaired reflexes as a result of fatigue or soft tissue creep may be contributing factors. Methods: A total of 15 healthy volunteers (8 females/7 males aged 23-55 years) underwent 2 interventions, on separate days: (a) sitting flexed for 1 hour to induce creep and (b) performing the Biering-Sorensen test to induce back muscle fatigue. Before and after each intervention, reflex activation of the erector spinae in response to sudden trunk flexion (initiated by a Kin-Com dynamometer) was monitored bilaterally at T10 and L3 using surface electromyography (EMG) electrodes. These recordings indicated the onset latency of reflex activation, the peak EMG, and time to peak, at each site. Measurements before and after each intervention and between muscle sites were compared using a 2-way repeated measures Analysis of Variance. Results: Spinal creep was confirmed by an increase in maximum flexion of 2.3° ± 2.5° (P = 0.003), and fatigue by a significant fall in median frequency at one or more sites. Following creep, onset latency increased from 60 ± 12 milliseconds to 96 ± 26 milliseconds (P < 0.001) but there was no change in peak EMG or time to peak EMG. Differences between sites (P = 0.004) indicated greater latencies in lumbar compared to thoracic regions, especially after creep. Muscle fatigue had no significant effects on any of the measured parameters. Conclusion: Prolonged spinal flexion can impair sensorimotor control mechanisms and reduce back muscle protection of the underlying spine. The effect is due to time-dependent "creep" in soft tissues rather than muscle fatigue. © 2010, Lippincott Williams & Wilkins. Source

Vergara-Martinez M.,University of California at Davis | Vergara-Martinez M.,University of Valencia | Swaab T.Y.,University of California at Davis
Psychophysiology | Year: 2012

The present study assessed the mechanisms and time course by which orthographic neighborhood size (ON) influences visual word recognition. ERPs were recorded to words that varied in ON and in word frequency while participants performed a semantic categorization task. ON was measured with the Orthographic Levenshtein Distance (OLD20), a richer metric of orthographic similarity than the traditional Coltheart's N metric. The N400 effects of ON (260-500ms) were larger and showed a different scalp distribution for low than for high frequency words, which is consistent with proposals that suggest lateral inhibitory mechanisms at a lexical level. The ERP ON effects had a shorter duration and different scalp distribution than the effects of word frequency (mainly observed between 380-600ms) suggesting a transient activation of the subset of orthographically similar words in the lexical network compared to the impact of properties of the single words. © 2012 Society for Psychophysiological Research. Source

King S.F.,University of Southampton | Morisi S.,University of Wurzburg | Peinado E.,National Institute of Nuclear Physics, Italy | Valle J.W.F.,University of Valencia
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2013

We propose a realistic A4 extension of the Standard Model involving a particular quark-lepton mass relation, namely that the ratio of the third family mass to the geometric mean of the first and second family masses are equal for down-type quarks and charged leptons. This relation, which is approximately renormalization group invariant, is usually regarded as arising from the Georgi-Jarlskog relations, but in the present model there is no unification group or supersymmetry. In the neutrino sector we propose a simple modification of the so-called Zee-Wolfenstein mass matrix pattern which allows an acceptable reactor angle along with a deviation of the atmospheric and solar angles from their bi-maximal values. Quark masses, mixing angles and CP violation are well described by a numerical fit. © 2013 Elsevier B.V. Source

Garcia-Llatas G.,University of Valencia | Rodriguez-Estrada M.T.,University of Bologna
Chemistry and Physics of Lipids | Year: 2011

Over the past 15 years, plant sterol-enriched foods have faced a great increase in the market, due to the asserted cholesterol-lowering effect of plant sterols. However, owing to their chemical structures, plant sterols can oxidize and produce a wide variety of oxidation products with controversial biological effects. Although oxyphytosterols can derive from dietary sources and endogenous formation, their single contribution should be better defined. The following review provides an overall and critical picture on the current knowledge and future perspectives of plant sterols-enriched food, particularly focused on occurrence of plant sterol oxidation products and their biological effects. The final objective of this overview is to evince the different aspects of plant sterols-enriched food that require further research, for a better understanding of the influence of plant sterols and their oxides on consumers' health. © 2011 Elsevier Ireland Ltd. Source

Armengot M.,University of Valencia
Investigative ophthalmology & visual science | Year: 2012

The cilium in photoreceptors appears ultrastructurally very similar to the nasal ciliated epithelium. The purpose of this study was to evaluate the nasal ciliary beat frequency and beat pattern in patients with retinitis pigmentosa (RP) and Usher syndrome type II and compare it with that of healthy control subjects. A prospective, comparative control study. Fresh samples of nasal mucosa were obtained from 13 patients with typical forms of RP, and from 4 patients with Usher syndrome type II. The nasal ciliary beat frequency (CBF) and beat pattern were determined using high-resolution digital high-speed video imaging (DHSV). The control group included 32 fresh nasal mucosa samples from 32 healthy volunteers without any other confounding diseases. The nasal CBF was lower in patients with Usher syndrome than in control subjects (Mann-Whitney U test, P = 0.01). The nasal CBF was 9.28 ± 0.4 (mean ± SD) Hz in patients with Usher syndrome and 10.82 ± 1.39 Hz in patients of the control group. No significant difference was observed in the nasal CBF between the RP (10.59 ± 1.54 Hz) and control group (Mann-Whitney U test, P = 0.64). Normal ciliary beat pattern was observed in all the patients and healthy volunteers. The nasal CBF is diminished in patients with Usher syndrome type II, whereas it remains normal in simplex RP patients. These results add evidence to the fact that Usher syndrome could be a primary ciliary disorder. Source

Mao B.,Rutgers University | Tejero R.,Rutgers University | Tejero R.,University of Valencia | Baker D.,University of Washington | Montelione G.T.,Rutgers University
Journal of the American Chemical Society | Year: 2014

We have found that refinement of protein NMR structures using Rosetta with experimental NMR restraints yields more accurate protein NMR structures than those that have been deposited in the PDB using standard refinement protocols. Using 40 pairs of NMR and X-ray crystal structures determined by the Northeast Structural Genomics Consortium, for proteins ranging in size from 5-22 kDa, restrained Rosetta refined structures fit better to the raw experimental data, are in better agreement with their X-ray counterparts, and have better phasing power compared to conventionally determined NMR structures. For 37 proteins for which NMR ensembles were available and which had similar structures in solution and in the crystal, all of the restrained Rosetta refined NMR structures were sufficiently accurate to be used for solving the corresponding X-ray crystal structures by molecular replacement. The protocol for restrained refinement of protein NMR structures was also compared with restrained CS-Rosetta calculations. For proteins smaller than 10 kDa, restrained CS-Rosetta, starting from extended conformations, provides slightly more accurate structures, while for proteins in the size range of 10-25 kDa the less CPU intensive restrained Rosetta refinement protocols provided equally or more accurate structures. The restrained Rosetta protocols described here can improve the accuracy of protein NMR structures and should find broad and general for studies of protein structure and function. © 2014 American Chemical Society. Source

Caro Gabalda I.,University of Valencia | Stiles W.B.,Miami University Ohio
Psychotherapy Research | Year: 2013

The assimilation model suggests progress in psychotherapy follows an eight-stage sequence described by the Assimilation of Problematic Experiences Scale (APES). This study sought to reconcile this developmental stage model with the common but superficially contradictory clinical observation that therapeutic advances alternate with setbacks. Setbacks (n=466) were identified in therapy transcripts of two clients and classified using a preliminary nine-category list of possible alternative reasons for setbacks. Most of the setbacks involved switches among the multiple strands of a problem due to (a) therapists exceeding clients' therapeutic zone of proximal development, (b) therapists guiding clients to shift toward relatively problematic material (balance metaphor), or (c) spontaneous switches. Rather than contradicting the theory, this close examination of setbacks yielded elaborations of it. © 2013 Copyright Society for Psychotherapy Research. Source

Quilis V.,University of Valencia | Trujillo I.,Institute of Astrophysics of Canarias | Trujillo I.,University of La Laguna
Astrophysical Journal Letters | Year: 2012

Minor merging has been postulated as the most likely evolutionary path to produce the increase in size and mass observed in the massive galaxies since z 2. In this Letter, we directly test this hypothesis, comparing the population of satellites around massive galaxies in cosmological simulations versus the observations. We use state-of-the-art, publically available, Millennium I and II simulations, and the associated semi-analytical galaxy catalogs to explore the time evolution of the fraction of massive galaxies that have satellites, the number of satellites per galaxy, the projected distance at which the satellites locate from the host galaxy, and the mass ratio between the host galaxies and their satellites. The three virtual galaxy catalogs considered here overproduce the fraction of galaxies with satellites by a factor ranging between 1.5 and 6 depending on the epoch, whereas the mean projected distance and ratio of the satellite mass over host mass are in closer agreement with data. The larger pull of satellites in the semi-analytical samples could suggest that the size evolution found in previous hydrodynamical simulations is an artifact due to the larger number of infalling satellites compared to the real universe. These results advise us to revise the physical ingredients implemented in the semi-analytical models in order to reconcile the observed and computed fraction of galaxies with satellites, and eventually, it would leave some room for other mechanisms explaining the galaxy size growth not related to the minor merging. © 2012. The American Astronomical Society. All rights reserved.. Source

Sunico C.R.,University of Cadiz | Gonzalez-Forero D.,University of Cadiz | Dominguez G.,University of Cadiz | Garcia-Verdugo J.M.,University of Valencia | Moreno-Lopez B.,University of Cadiz
Journal of Neuroscience | Year: 2010

The molecular signaling that underpins synapse loss in neuropathological conditions remains unknown. Concomitant upregulation of the neuronal nitric oxide (NO) synthase (nNOS) in neurodegenerative processes places NO at the center of attention. We found that de novo nNOS expression was sufficient to induce synapse loss from motoneurons at adult and neonatal stages. In brainstem slices obtained from neonatal animals, this effect required prolonged activation of the soluble guanylyl cyclase (sGC)/protein kinase G (PKG) pathway and RhoA/Rho kinase (ROCK) signaling. Synapse elimination involved paracrine/retrograde action of NO. Furthermore, before bouton detachment, NO increased synapse myosin light chain phosphorylation (p-MLC), which is known to trigger actomyosin contraction and neurite retraction. NO-induced MLC phosphorylation was dependent on cGMP/PKG-ROCK signaling. In adulthood, motor nerve injury induced NO/cGMP-dependent synaptic stripping, strongly affecting ROCK-expressing synapses, and increased the percentage of p-MLC-expressing inputs before synapse destabilization. We propose that this molecular cascade could trigger synapse loss underlying early cognitive/motor deficits in several neuropathological states. Copyright © 2010 the authors. Source

Walczynska A.,Jagiellonian University | Serra M.,University of Valencia
Hydrobiologia | Year: 2014

The strategy of decreasing size with increasing temperature operates at regional and phenotypic scale and presents a puzzle to researchers. In this work, we studied two aspects of the temperature-performance relationship along a temperature gradient, (i) comparing the population growth rates of three cryptic Brachionus species differing in adult size, and (ii) assessing the phenotypic plasticity of adult size, in one clone per species. The working hypotheses were that (i) the bigger the species the lower its optimal temperature for population growth, and (ii) the higher the temperature the smaller the individual within each focal species. The results showed that (i) the optimal temperature for population growth is related to species size in a manner foreseen by Bergmanns' rule for two of the three species (the third, biggest species, performed evenly well at all temperatures examined, what could be explained by its generally eurioic character), and that (ii) the strategy of body size adjustment to environmental temperature differs between species and may depend on the level of temperature specialization. This work demonstrated the usefulness of inter- and intraspecific comparisons for studying the role of growth strategies in adaptation to temperature. © 2014 Springer International Publishing Switzerland. Source

Eustaquio M.V.,University of Valencia
Medicina oral, patología oral y cirugía bucal | Year: 2010

Ascertain the oral health status of the adult population in the Valencia region of Spain. A cross sectional prevalence study was conducted on a sample of 1264 adults, comprising 733 individuals aged 35-44 years and 531 individuals aged 65-74 years. Data collection was carried out in 2006. In both age groups (younger adults and older adults), the clinical examinations were carried out by calibrated dentists (Kappa <0.76). The caries prevalence in the group of 35-44 year-old subjects was 92.2% (DMFT=7.64). In the group of 65-74 year-old subjects, it was 98.3% (DMFT=16.38). The F/DMFT percentage of the younger adults was 66% and that of the older adults was 16.3%. The edentate percentage was 0.1% in the group of 35-44 year-old subjects and 20.7% in the group of 65-74 year-old subjects. Calculus prevalence was almost 60% among the younger adults. Nearly 22% of the younger adults and 26% older adults presented periodontal pockets, although only a minority (4.6% and 4.3%) were CPI score 4. Significant differences in the various indices were found in relation to institutionalization and socio-economic status. The caries prevalence (DMFT>0) found in the two age groups studied remains very high: over 90%. The worst health status is found in certain groups, such as the institutionalized elderly and adults with a low socio-economic status. Source

Positive psychology has boosted interest about the study of factors of adjustment, among which is included satisfaction with life. To analyze the relationship between satisfaction with life of children with attention deficit hyperactivity disorder (ADHD) and their parents with behavioral risk and protective variables, and to determine the predictive power of these variables. 56 parents and their children with ADHD filled out questionnaires of satisfaction with life, self-concept, sense of coherence, success attributes and behavioral rating scales. Behavioral problems have a significant negative relationship with satisfaction with life perceived by parents and by children while the relationships with the self-concept and success attributes have a positive value. The most predictive factors were social problems, oppositional behavior, self-concept, self-awareness and social support. The identification of factors that put at risk or enhance satisfaction with life of people with ADHD will improve the functionality of evaluation and intervention processes. Source

The emergence and pandemic spread of a new strain of influenza A (H1N1) virus in 2009 resulted in a serious alarm in clinical and public health services all over the world. One distinguishing feature of this new influenza pandemic was the different profile of hospitalized patients compared to those from traditional seasonal influenza infections. Our goal was to analyze sociodemographic and clinical factors associated to hospitalization following infection by influenza A(H1N1) virus. We report the results of a Spanish nationwide study with laboratory confirmed infection by the new pandemic virus in a case-control design based on hospitalized patients. The main risk factors for hospitalization of influenza A (H1N1) 2009 were determined to be obesity (BMI≥40, with an odds-ratio [OR] 14.27), hematological neoplasia (OR 10.71), chronic heart disease, COPD (OR 5.16) and neurological disease, among the clinical conditions, whereas low education level and some ethnic backgrounds (Gypsies and Amerinds) were the sociodemographic variables found associated to hospitalization. The presence of any clinical condition of moderate risk almost triples the risk of hospitalization (OR 2.88) and high risk conditions raise this value markedly (OR 6.43). The risk of hospitalization increased proportionally when for two (OR 2.08) or for three or more (OR 4.86) risk factors were simultaneously present in the same patient. These findings should be considered when a new influenza virus appears in the human population. Source

Pinero D.P.,Oftalmar | Nieto J.C.,University of Alicante | Nieto J.C.,University of Valencia | Lopez-Miguel A.,University of Valladolid
Journal of Cataract and Refractive Surgery | Year: 2012

The increasing volume of patients interested in refractive surgery and the new treatment options available for keratoconus have generated a higher interest in achieving a better characterization of this pathology. The ophthalmic devices for corneal analysis and diagnosis have experienced a rapid development during the past decade with the implementation of technologies such as the Placido-disk corneal topography and the introduction of others such as scanning-slit topography, Scheimpflug photography, and optical coherence tomography, which are able to accurately describe not only the geometry of the anterior corneal surface but also that of the posterior surface, as well as pachymetry and corneal volume. Specifically, anterior and posterior corneal elevation, corneal power, pachymetry maps, and corneal coma-like aberrometry data provide sufficient information for an accurate characterization of the cornea to avoid misleading diagnoses of patients and provide appropriate counseling of refractive surgery candidates. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned. © 2012 ASCRS and ESCRS. Source

Serodio H.,University of Valencia
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

A general method for classifying the possible quark models of a multi-Higgs-doublet model, in the presence of Abelian symmetries, is presented. All the possible sets of textures that can be present in a given sector are shown, thus turning the determination of the flavor models into a combinatorial problem. Several symmetry implementations are studied for two and three Higgs doublet models. Some models' implementations are explored in great detail, with a particular emphasis on models known as Branco-Grimus-Lavoura and nearest-neighbor-interaction. Several considerations on the flavor changing neutral currents of multi-Higgs models are also given. © 2013 American Physical Society. Source

Aguilar-Saavedra J.A.,University of Granada | Bernabeu J.,University of Valencia | Bernabeu J.,CERN
Nuclear Physics B | Year: 2010

We calculate the density matrix for the decay of a polarised top quark into a polarised W boson and a massive b quark, for the most general Wtb vertex arising from dimension-six gauge-invariant effective operators. We show that, in addition to the well-known W helicity fractions, for polarised top decays it is worth defining and studying the transverse and normal W polarisation fractions, that is, the W polarisation along two directions orthogonal to its momentum. In particular, a rather simple forward-backward asymmetry in the normal direction is found to be very sensitive to complex phases in one of the Wtb anomalous couplings. This asymmetry, which indicates a normal W polarisation, can be generated for example by a P-odd, T-odd transition electric dipole moment. We also investigate the angular distribution of decay products in the top quark rest frame, calculating the spin analysing powers for a general Wtb vertex. Finally we show that, using a combined fit to top decay observables and the tW cross section, at LHC it will be possible to obtain model-independent measurements of all the (complex) Wtb couplings as well as the single top polarisation. Implications for spin correlations in top pair production are also discussed. © 2010 Elsevier B.V. Source

Albertus C.,University of Salamanca | Hernandez E.,University of Salamanca | Nieves J.,University of Valencia
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2010

We investigate the role of hyperfine mixing in the electromagnetic decay of ground state doubly heavy bc baryons. As in the case of a previous calculation on b → c semileptonic decays of doubly heavy baryons, we find large corrections to the electromagnetic decay widths due to this mixing. Contrary to the weak case just mentioned, we find here that one cannot use electromagnetic width relations obtained in the infinite heavy quark mass limit to experimentally extract information on the admixtures in a model independent way. © 2010 Elsevier B.V. All rights reserved. Source

Pereto J.,University of Valencia
Chemical Society Reviews | Year: 2012

The origin of life on Earth was a chemical affair. So how did primitive biochemical systems originate from geochemical and cosmochemical processes on the young planet? Contemporary research into the origins of life subscribes to the Darwinian principle of material causes operating in an evolutionary context, as advocated by A. I. Oparin and J. B. S. Haldane in the 1920s. In its simplest form (e.g., a bacterial cell) extant biological complexity relies on the functional integration of metabolic networks and replicative genomes inside a lipid boundary. Different research programmes have explored the prebiotic plausibility of each of these autocatalytic subsystems and combinations thereof: self-maintained networks of small molecules, template chemistry, and self-reproductive vesicles. This tutorial review focuses on the debates surrounding the origin of metabolism and offers a brief overview of current studies on the evolution of metabolic networks. I suggest that a leitmotif in the origin and evolution of metabolism is the role played by catalysers' substrate ambiguity and multifunctionality. © 2012 The Royal Society of Chemistry. Source

Farkkila M.,University of Helsinki | Diener H.-C.,University of Duisburg - Essen | Geraud G.,Toulouse University Hospital Center | Lainez M.,University of Valencia | And 4 more authors.
The Lancet Neurology | Year: 2012

Background: Lasmiditan (COL-144) is a novel, centrally acting, highly selective 5-HT 1F receptor agonist without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study. We aimed to assess the efficacy and safety of oral lasmiditan for the acute treatment of migraine. Methods: In this multicentre, double-blind, parallel-group, dose-ranging study in 43 headache centres in five European countries, patients with migraine with and without aura and who were not using prophylaxis were randomly assigned (1:1:1:1:1) to treat one moderate or severe attack at home with 50 mg, 100 mg, 200 mg, or 400 mg lasmiditan, or placebo. Study drug and placebo were supplied in identical numbered tablet packs. The randomisation code was generated by an independent statistician. Patients and investigators were masked to treatment allocation. The primary endpoint was dose response for headache relief (moderate or severe becoming mild or none) at 2 h. The primary analysis was done in the modified intention-to-treat population. This study is registered with ClinicalTrials.gov, number NCT00883051. Findings: Between July 8 2009, and Feb 18, 2010, 512 patients were randomly assigned to treatment, 391 of whom received treatment. 86 patients received placebo (81 included in primary analysis) and 305 received lasmiditan (50 mg n=79, 100 mg n=81, 200 mg n=69, and 400 mg n=68 included in primary analysis). There was a linear association between headache response rate at 2 h and lasmiditan dose (Cochran-Armitage test p<0·0001). Every lasmiditan treatment dose significantly improved headache response at 2 h compared with placebo (lasmiditan 50 mg: difference 17·9%, 95% CI 3·9-32·1, p=0·022; 100 mg: 38·2%, 24·1-52·4, p<0·0001; 200 mg: 28·8%, 9·6-39·9, p=0·0018; 400 mg: 38·7%, 23·9-53·6, p<0·0001). The proportion of patients with treatment-emergent adverse events increased with increasing doses (53/82 [65%], 59/82 [72%], 61/71 [86%], and 59/70 [84%] for lasmiditan 50, 100, 200, and 400 mg, respectively vs 19/86 [22%] for placebo). Most adverse events were mild or moderate in intensity, with 16 of 82 (20%), 23 of 82 (28%), 28 of 71 (39%), and 31 of 70 (44%) of patients on lasmiditan 50, 100, 200, and 400 mg, respectively reporting a severe adverse event compared with five of 86 (6%) on placebo. The most common adverse events were CNS related and included dizziness, fatigue, vertigo, paraesthesia, and somnolence. Interpretation: Oral lasmiditan seems to be safe and effective in the acute treatment of migraine. Further assessment in larger placebo-controlled and triptan-controlled trials are needed to assess the potential role of lasmiditan in acute migraine therapy. Funding: CoLucid Pharmaceuticals. © 2012 Elsevier Ltd. Source

Boix J.,University of Otago | Cauli O.,University of Valencia
Neurochemistry International | Year: 2012

Although commercial production of polychlorinated biphenyls (PCBs) was banned in 1979, PCBs continue to be an environmental and health concern due to their high bioaccumulation and slow degradation rates. In fact, PCBs are still present in our food supply (fish, meat, and dairy products). In laboratory animals, exposure to single PCB congener or to mixtures of different congeners induces a variety of physiological alterations. PCBs cross the placenta and even exposure at low level is harmful for the foetus by leading to neurodevelopment alterations. Serotonin system which regulates many physiological functions from platelet activation to high cerebral processes and neurodevelopment is one of the targets of PCBs toxicity. The effects of PCBs exposure on serotonin system have been investigated although to a lesser extent compared to its effect in other neurotransmitter systems. This review provides a summary of the results concerning the impact of PCBs exposure (in vitro and in vivo) on serotonin system. Further research is needed to correlate specific deficits with PCB-induced changes in the serotonin system. © 2012 Elsevier Ltd. All rights reserved. Source

Lai M.,University of Pennsylvania | Huijbers M.G.M.,University of Pennsylvania | Lancaster E.,University of Pennsylvania | Graus F.,Institute dInvestigacio Biomedica August Pi i Sunyer IDIBAPS | And 4 more authors.
The Lancet Neurology | Year: 2010

Background: Voltage-gated potassium channels are thought to be the target of antibodies associated with limbic encephalitis. However, antibody testing using cells expressing voltage-gated potassium channels is negative; hence, we aimed to identify the real autoantigen associated with limbic encephalitis. Methods: We analysed sera and CSF of 57 patients with limbic encephalitis and antibodies attributed to voltage-gated potassium channels and 148 control individuals who had other disorders with or without antibodies against voltage-gated potassium channels. Immunohistochemistry, immunoprecipitation, and mass spectrometry were used to characterise the antigen. An assay with HEK293 cells transfected with leucine-rich, glioma-inactivated 1 (LGI1) and disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) or ADAM23 was used as a serological test. The identity of the autoantigen was confirmed by immunoabsorption studies and immunostaining of Lgi1-null mice. Findings: Immunoprecipitation and mass spectrometry analyses showed that antibodies from patients with limbic encephalitis previously attributed to voltage-gated potassium channels recognise LGI1, a neuronal secreted protein that interacts with presynaptic ADAM23 and postsynaptic ADAM22. Immunostaining of HEK293 cells transfected with LGI1 showed that sera or CSF from patients, but not those from control individuals, recognised LGI1. Co-transfection of LGI1 with its receptors, ADAM22 or ADAM23, changed the pattern of reactivity and improved detection. LGI1 was confirmed as the autoantigen by specific abrogation of reactivity of sera and CSF from patients after immunoabsorption with LGI1-expressing cells and by comparative immunostaining of wild-type and Lgi1-null mice, which showed selective lack of reactivity in brains of Lgi1-null mice. One patient with limbic encephalitis and antibodies against LGI1 also had antibodies against CASPR2, an autoantigen we identified in some patients with encephalitis and seizures, Morvan's syndrome, and neuromyotonia. Interpretation: LGI1 is the autoantigen associated with limbic encephalitis previously attributed to voltage-gated potassium channels. The term limbic encephalitis associated with antibodies against voltage-gated potassium channels should be changed to limbic encephalitis associated with LGI1 antibodies, and this disorder should be classed as an autoimmune synaptic encephalopathy. Funding: National Institutes of Health, National Cancer Institute, and Euroimmun. © 2010 Elsevier Ltd. Source

Papavassiliou J.,University of Valencia
Nuclear Physics B - Proceedings Supplements | Year: 2010

The Green's functions of QCD encode important information about the infrared dynamics of the theory. The main non-perturbative tools used to study them are their own equations of motion, known as Schwinger-Dyson equations, and large-volume lattice simulations. We have now reached a point where the interplay between these two methods can be most fruitful. Indeed, the quality of the lattice data is steadily improving, while a recently introduced truncation scheme for the Schwinger-Dyson equations makes their predictions far more reliable. In this talk several of the above points will be reviewed, with particular emphasis on how to enforce the crucial requirement of gauge invariance at the level of the Schwinger-Dyson equations, the detailed mechanism of dynamical gluon mass generation and its implications for the ghost sector, the non-perturbative effective charge of QCD, and the indirect extraction of the Kugo-Ojima function from existing lattice data. © 2010 Elsevier B.V. Source

Aguilar A.C.,University of Campinas | Binosi D.,Fondazione Bruno Kessler | Papavassiliou J.,University of Valencia
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2015

In this paper we use two different but complementary approaches in order to study the ghost propagator of a pure SU(3) Yang-Mills theory quantized in the linear covariant gauges, focusing on its dependence on the gauge-fixing parameter ξ in the deep infrared. In particular, we first solve the Schwinger-Dyson equation that governs the dynamics of the ghost propagator, using a set of simplifying approximations, and under the crucial assumption that the gluon propagators for ξ>0 are infrared finite, as is the case in the Landau gauge (ξ=0). Then we appeal to the Nielsen identities, and express the derivative of the ghost propagator with respect to ξ in terms of certain auxiliary Green's functions, which are subsequently computed under the same assumptions as before. Within both formalisms we find that for ξ>0 the ghost dressing function approaches zero in the deep infrared, in sharp contrast to what happens in the Landau gauge, where it is known to saturate at a finite (nonvanishing) value. The Nielsen identities are then extended to the case of the gluon propagator, and the ξ-dependence of the corresponding gluon masses is derived using as input the results obtained in the previous steps. The result turns out to be logarithmically divergent in the deep infrared; the compatibility of this behavior with the basic assumption of a finite gluon propagator is discussed, and a specific Ansatz is put forth, which readily reconciles both features. © 2015 American Physical Society. Source

Binosi D.,Fondazione Bruno Kessler | Chang L.,University of Adelaide | Papavassiliou J.,University of Valencia | Roberts C.D.,Argonne National Laboratory
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2015

Within contemporary hadron physics there are two common methods for determining the momentum-dependence of the interaction between quarks: the top-down approach, which works toward an ab initio computation of the interaction via direct analysis of the gauge-sector gap equations; and the bottom-up scheme, which aims to infer the interaction by fitting data within a well-defined truncation of those equations in the matter sector that are relevant to bound-state properties. We unite these two approaches by demonstrating that the renormalisation-group-invariant running-interaction predicted by contemporary analyses of QCD's gauge sector coincides with that required in order to describe ground-state hadron observables using a nonperturbative truncation of QCD's Dyson-Schwinger equations in the matter sector. This bridges a gap that had lain between nonperturbative continuum-QCD and the ab initio prediction of bound-state properties. © 2015. Source

Peiro-Palomino J.,University of Valencia
Annals of Regional Science | Year: 2016

The contributions evaluating convergence across European regions are now numerous and take a wide variety of approaches. However, evidence for the most recent years is still scant, and studies considering the role of intangible assets in the enlarged European Union are virtually nonexistent. This article focuses on the convergence patterns of income per capita in 260 European regions during the period 2000–2011. Following the distribution dynamics approach, the role of a set of intangible assets is considered by introducing several conditioning schemes. In line with previous contributions the results suggest that the distribution of income is bimodal. The regional stocks of the different intangible assets considered have some power for explaining convergence tendencies in the studied period. © 2016, Springer-Verlag Berlin Heidelberg. Source

Bou-Franch P.,University of Valencia
Journal of Pragmatics | Year: 2011

Despite the increasing interest scholarly research has shown in the study of computer-mediated communication, there is still a need to investigate the empirical validity of assumed homogeneity of language usage over the net and focus on the social diversity and variation that characterizes any communication. With this in mind, the present paper is an investigation into the stylistic choices that a particular group of email users made when engaged in a specific activity type. More specifically, it explores the variation in the discourse practices employed to open and close emails in conversation alongside the institutional power of participants and the interactional position of each email contributing to the conversation.To carry out this study a corpus of short email conversations in Peninsular Spanish was collected (n=240). The analysis focused on the opening and closing sequences of the emails that made up the conversations and considered opening and closing linguistic conventions as discursive practices that members of a community may use strategically. The findings revealed that the discursive practices under scrutiny were subject not only to technological but also to social and interactional constraints and thus highlighted contextual variability. Further, the high degree of sociability in the electronic episodes studied was interpreted as reflecting a " people first, business second" communicative style. © 2010 Elsevier B.V. Source

Esteban J.,University of Valencia | Martinez M.,University of Barcelona
Dalton Transactions | Year: 2011

The protonation/demetallation reaction, in CD3COOD, of phosphine monometallated triacetato-bridged dirhodium(ii) complexes of general formulae [Rh2(μ-OOCCH3)3{(RC5CH 3)P(RC6H4)2}2] has been studied from a kinetico-mechanistic perspective. The process has been monitored via the disappearance of the nuclear magnetic resonance signals of the protons present in the non-metallated ortho positions of the phosphine ligand and taking advantage of the relatively fast back metallation process that follows the acidolysis reaction, the sequence behaving as an overall equilibrium reaction. The process has a high associative character with important entropy demands, increasing both for the larger and the more electron withdrawing phosphine ligands. For the complexes with electron withdrawing CF3 substituents on the cyclometallated phenyl ring, this demand is compensated by very low activation enthalpies. The data agree with an intimate mechanism that corresponds to the reverse of the electrophilic C-H bond activation, which has already been studied for this type of system, and requires the presence of a protonated acetato ligand in the axial position, close to the metallated Rh-Caromatic bond. The involvement of external solvent molecules, interacting via hydrogen bonds with the system, is also evident for systems which include CF3 groups with the correct geometric arrangement. © 2011 The Royal Society of Chemistry. Source

Guruceaga E.,University of Navarra | Sanchez Del Pino M.M.,University of Valencia | Corrales F.J.,University of Navarra | Segura V.,University of Navarra
Journal of Proteome Research | Year: 2015

Experimental evidence for the entire human proteome has been defined in the Human Proteome Project, and it is publicly available in the neXtProt database. However, there are still human proteins for which reliable experimental evidence does not exist, and the identification of such information has become one of the overriding objectives in the chromosome-centric study of the human proteome. With this aim and considering the complexity of protein detection using shotgun and targeted proteomics, the research community has addressed the integration of transcriptomics and proteomics landscapes. Here, we describe an analytical pipeline that predicts the probability of a missing protein being expressed in a biological sample based on (1) gene sequence characteristics, (2) the probability of an expressed gene being a coding gene of a missing protein in a certain sample, and (3) the probability of a gene being expressed in a transcriptomic experiment. More than 3400 microarray experiments were analyzed corresponding to three biological sources: cell lines, normal tissues, and cancer samples. A gene classification based on gene expression profiles distinguished among ubiquitous, nonubiquitous, nonexpressed, and coding genes of missing proteins. In addition, a different tissue-specific expression pattern for the coding genes of missing proteins is reported. Our results underline the relevance of selecting an appropriate sample for the detection of missing proteins and provide a comprehensive method to score their expression probability. Testis, brain, and skeletal muscle are the most promising normal tissues. © 2015 American Chemical Society. Source

Domingo-Pardo C.,University of Valencia
Acta Physica Polonica B | Year: 2016

Beta-delayed neutrons play a key role in the formation of heavy elements in explosive stellar environments. The final r-process abundance distribution, including the rare-earth peak, is tailored to a large extent by the neutrons released after the beta decay of very exotic neutron-rich nuclei encountered along the r-process path and during the freeze-out phase. Such scenarios involve a vast amount of - yet undiscovered - nuclei, and most of them are expected to be neutron emitters. In this respect, existing beta-delayed neutron emission data is rather scarce, spanning from the lightest isotopes up to the region of the fission-fragments with masses up to A - 150. This contribution gives an overview on the latest measurements of neutron branching ratios in the heavy mass region around N = 126, which was practically unexplored in the past. Present plans to access very exotic nuclei at the RIB-facility of RIKEN in the framework of the BRIKEN project, are presented, together with the expected impact in r-process nucleosynthesis studies. Source

Pavia J.M.,University of Valencia
Journal of Statistical Software | Year: 2015

To assess the goodness-of-fit of a sample to a continuous random distribution, the most popular approach has been based on measuring, using either L1- or L2-norms, the distance between the null hypothesis cumulative distribution function and the empirical cumulative distribution function. Indeed, as far as I know, almost all the tests currently available in R related to this issue (ks.test in package stats, ad.test in package AD- GofTest, and ad.test, ad2.test, ks.test, v.test and w2.test in package truncgof) use one of these two distances on cumulative distribution functions. This paper (i) proposes dgeometric.test, a new implementation of the test that measures the discrepancy between a sample kernel estimate of the density function and the null hypothesis density function on the L1-norm, (ii) introduces the GoFKernel package, and (iii) performs a large simulation exercise to assess the calibration and sensitivity of the above listed tests as well as the Fan's test (Fan 1994), fan. test, also implemented in the GoFKernel package. In addition to dgeometric.test and fan.test, the GoFKernel package adds a couple of functions that R users might also and of interest: density.reflected extends density, allowing the computation of consistent kernel density estimates for bounded random variables, and random. function o_ers an ad-hoc and universal (although computational expensive and potentially inaccurate for long tail distributions) sampling method. In light of the simulation results, we can conclude that (i) the tests implemented in the truncgof package should not be used to assess goodness-of-_t (at least for non-truncated distributions), (ii) the test fan.test shows an over-tendency to not reject the null hypothesis, being visibly miscalibrated (at least in its default option, where the bandwidth parameter is estimated using dpik from package KernSmooth), (iii) the tests ks.test and ad.test show similar power, with ad. test being slightly preferable in large samples, and (iv) dgeometric.test represents a good alternative given its satisfactory calibration and its, in general, superior power in samples of medium and large sizes. As a counterpart it entails more computational burden when the random generator of the null hypothesis density function is not available in R and random. function must be used. © 2015, American Statistical Association. All rights reserved. Source

The importance of calcium in human nutrition, the mechanisms of absorption and excretion of the element, and the factors affecting them with special reference to dietary factors are described. After reviewing daily dietary intakes of calcium and the main contributors in European and Spanish population, recommended intakes in Spain, the Nordic countries and the United States are mentioned. In relation to the dietary sources of calcium it has to be noted that the value of a given food as a source of a nutrient depends on its content in the food, the bioavailability of the nutrient and the usual food consumption. The calcium contents of potential food sources of the element are reported and its value is estimated according to the potential absorbability of the calcium they contain. The benefits of milk and dairy products as sources of calcium are also highlighted. Populations such as children or elderly may require fortified foods or supplements to satisfy their high calcium needs, so some examples of the efficacy of this supplementation are discussed. It is concluded that food and drinks are the best choice to obtain calcium. Taking into account the calcium content, the usual portion size and the consumption habits milk and dairy products, nuts, green leafy vegetables and legumes can provide adequate amounts of calcium. However, milk and dairy products constitute the best dietary source thanks to the bioavailability of the calcium they contain. © 2015, Grupo Aula Medica S.A. All rights reserved. Source

Armentano D.,University of Calabria | Martinez-Lillo J.,University of Valencia
Inorganica Chimica Acta | Year: 2012

Two novel rhenium(IV)-ruthenium(III) compounds of formulae [RuCl(NH 3) 5] 2[ReCl 6]Cl 2 (1) and [RuCl 2(en) 2] 2[ReCl 6]·2CH 3CN (2) (en = 1,2-ethylenediamine) have been prepared and characterized. Their crystal structures were determined by single-crystal X-ray diffraction. 1 crystallizes in the monoclinic system with C2/m as space group, whereas 2 crystallizes in the triclinic system with space group P(-1). The crystal structures of 1 and 2 are made up of discrete [ReCl 6] 2- anions and [RuCl(NH 3) 5] 2+ (1) or [RuCl 2(en) 2] + (2) cations held together by N-H⋯Cl hydrogen bonds, van der Waals and electrostatic forces. The magnetic properties were investigated from susceptibility measurements performed on polycrystalline samples of 1 and 2 in the temperature range 1.9-300 K. In both compounds, the variation of χ MT in the high-temperature range reveals an antiferromagnetic coupling whereas they exhibit behaviour typical of spin-canted systems with magnetic ordering below ca. 11.0 (1) and ca. 4.5 K (2). © 2011 Elsevier B.V. All rights reserved. Source

Cavadas P.C.,University of Valencia
Hand clinics | Year: 2011

This article summarizes the findings from 3 recipients of hand allografts, including a description of the preparatory surgery and the transplant and secondary procedures to enhance the function of the hand, forearm, and arm allografts. The study focuses on the complications and disability reported by each patient, with a minimum follow-up of 2 years. The few complications were controlled successfully with medical treatment. Hand transplantation is a major reconstructive procedure that requires careful medical follow-up. The authors provide the first report of a significant improvement in disabilities of the upper limb as a result of hand allotransplantation. Copyright © 2011 Elsevier Inc. All rights reserved. Source

Choliz M.,University of Valencia
Journal of Gambling Studies | Year: 2010

Slot machines are the most "addictive" games because (a) the disorder (pathological gambling) appears more rapidly in these games than with any other; (b) most patients who seek professional help are mainly addicted to electronic gambling, and (c) even though it is not the more frequent game, most of all the money spent on legal games of chance (at least in Spain) goes to slot machines. Structural characteristics of slot machines induce to gamble because electronic games show the main parameters of operant conditioning, mainly the immediacy of the reinforcement. Ten pathological gamblers played slot machine in two conditions: immediate and delayed reinforcement. The results corroborate the importance of the immediacy of the reinforcement in gambling, because when the result appears immediately (after 2 s), more games are played than when the result is delayed only 10 s. Critical issues in problem gambling prevention and public health are discussed. © 2009 Springer Science+Business Media, LLC. Source

Ibanez J.-J.,University of Valencia | Effland W.R.,U.S. Department of Agriculture
Geomorphology | Year: 2011

The Theory of Island Biogeography has been based on biodiversity studies and used as a powerful predictive tool. Currently pedogeography does not have a similar theoretical construct. Although island biodiversity and biological assemblages have been topics of widespread interest in biogeography, ecology and conservation biology, soil scientists have conducted few studies of pedodiversity and pedological assemblages in archipelagos. Several studies have demonstrated that pedodiversity and biodiversity patterns have striking similarities in very disparate environments and at different scales, thus it is possible to test for a similar construct of island pedogeography. We analyze similarities and differences in the pedosphere for three archipelagos with different origins: (i) oceanic-intra-plate chains islands (Hawaiian Islands), (ii) oceanic-intra-plate cluster islands (Canary Islands), (iii) non-marine land-bridge islands with volcanism associated with plate boundary conditions (Aegean Islands) and (iv) as a comparison, islands in a nonplate boundary setting (the British Isles).In the Canary Islands, we also compiled selected biological, physiographical, geological and climatic data for further analysis of pedodiversity, climatic diversity, geodiversity and biodiversity. Our pedogeographic analysis of the three archipelagos indicates archipelagos of varying origins contain different soil assemblages with plate tectonics as the main driving force. The similarities between pedodiversity and biodiversity are more remarkable than the differences.We tested the hypothesis that soil taxa distributions on island chains can be modelled as a power function similar to the species-area relationship (SAR) proposed by McArthur and Wilson for archipelagos. The SAR functional relationship has been widely corroborated in other biodiversity studies. The same patterns were obtained for pedodiversity and biodiversity in the British Isles, and after that in the Aegean Archipelago. In this study we show similar results in the Canary Islands. Furthermore, in the Canary Archipelago, a strong relationship exists between pedodiversity, biodiversity, climate diversity, habitat heterogeneity and relief. For the Hawaii Archipelago, we did not obtain a statistically significant relationship because soil inventories are not published for the smallest islands and islets. However, Hawaii does have a chronosequence from the older to the younger land units. Overall, the dynamics of the underlying plate tectonic hot spots seems to be the major driving force affecting the various diversity types.Based on these results, we suggest a theoretical proposal of Island pedogeography consistent and similar to the Theory of Island Biogeography, in view that the latter one also predicts the pedodiversity of soil assemblages in archipelagos. This study illustrates several possibilities for further research in soil geography. © 2011 Elsevier B.V. Source

Volpe C.,CNRS Astroparticle and Cosmology Lab | Vaananen D.,CNRS Astroparticle and Cosmology Lab | Espinoza C.,University of Lisbon | Espinoza C.,University of Valencia
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

We derive the evolution equations for a system of neutrinos interacting among themselves and with a matter background, based upon the Bogoliubov-Born-Green-Kirkwood-Yvon hierarchy. This theoretical framework gives an (unclosed) set of first-order coupled integro-differential equations governing the evolution of the reduced density matrices. By employing the hierarchy, we first rederive the mean-field evolution equations for the neutrino one-body density matrix associated with a system of neutrinos and antineutrinos interacting with matter and with an anisotropic neutrino background. Then, we derive extended evolution equations to determine neutrino flavor conversion beyond the commonly used mean-field approximation. To this aim we include neutrino-antineutrino pairing correlations to the two-body density matrix. The inclusion of these new contributions leads to an extended evolution equation for the normal neutrino density and to an equation for the abnormal one involving the pairing mean field. We discuss the possible impact of neutrino-antineutrino correlations on neutrino flavor conversion in the astrophysical and cosmological environments, and possibly upon the supernova dynamics. Our results can be easily generalized to an arbitrary number of neutrino families. © 2013 American Physical Society. Source

Salvatelli V.,University of Rome La Sapienza | Marchini A.,University of Rome La Sapienza | Lopez-Honorez L.,Vrije Universiteit Brussel | Mena O.,University of Valencia
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

We present new constraints on coupled dark energy from the recent measurements of the cosmic microwave background anisotropies from the Planck satellite mission. We found that a coupled dark energy model is fully compatible with the Planck measurements, deriving a weak bound on the dark matter-dark energy coupling parameter ξ=-0.49-0.31+0.19 at 68% C.L. Moreover if Planck data are fitted to a coupled dark energy scenario, the constraint on the Hubble constant is relaxed to H0=72.1-2.3+3.2 km/s/Mpc, solving the tension with the Hubble Space Telescope (HST) value. We show that a combined PLANCK+HST analysis provides significant evidence for coupled dark energy finding a nonzero value for the coupling parameter ξ, with -0.90<ξ<-0.22 at 95% C.L. We also consider the combined constraints from the Planck data plus the baryon acoustic oscillation measurements of the 6dF Galaxy Survey, the Sloan Digital Sky Survey and the Baron Oscillation Spectroscopic Survey. © 2013 American Physical Society. Source

Aguilar A.C.,University of Campinas | Binosi D.,Fondazione Bruno Kessler | Papavassiliou J.,University of Valencia
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

We study in detail the impact of dynamical quarks on the gluon mass generation mechanism, in the Landau gauge, for the case of a small number of quark families. As in earlier considerations, we assume that the main bulk of the unquenching corrections to the gluon propagator originates from the fully dressed quark-loop diagram. The nonperturbative evaluation of this diagram provides the key relation that expresses the unquenched gluon propagator as a deviation from its quenched counterpart. This relation is subsequently coupled to the integral equation that controls the momentum evolution of the effective gluon mass, which contains a single adjustable parameter; this constitutes a major improvement compared to the analysis presented in Aguilar et al., where the behavior of the gluon propagator in the deep infrared was estimated through numerical extrapolation. The resulting nonlinear system is then treated numerically, yielding unique solutions for the modified gluon mass and the quenched gluon propagator, which fully confirms the picture put forth recently in several continuum and lattice studies. In particular, an infrared finite gluon propagator emerges, whose saturation point is considerably suppressed, due to a corresponding increase in the value of the gluon mass. This characteristic feature becomes more pronounced as the number of active quark families increases, and can be deduced from the infrared structure of the kernel entering in the gluon mass equation. © 2013 American Physical Society. Source

Fustero S.,University of Valencia | Acena J.L.,Research Center Principe Felipe | Catalan S.,Research Center Principe Felipe
Topics in Current Chemistry | Year: 2012

The search for new and better techniques for the purification of organic compounds has made the recent emergence of fluorous chemistry in the field of organic synthesis possible. Using fluorous reagents as phase tags allows for the access of different synthetic routes, and this has been translated into a time reduction and higher simplicity compared to standard, nonfluorous procedures. The synthesis in fluorous phase of target molecules can be pursued in a parallel or combinatorial manner in order to access chemical libraries with structural and/or stereochemical diversity. The preparation of radiolabeled molecules also benefits from the advantages of fluorous synthesis. Finally, biochemical tools such as microarrays or proteomic techniques are improved by means of fluorous-tagged compounds. © 2011 Springer-Verlag Berlin-Heidelberg. Source

Esparcia J.,University of Valencia
Journal of Rural Studies | Year: 2014

Innovation is a central factor for the development of rural areas, both in terms of diversification and increased competitiveness, also related to new structures of governance. The creation, adoption or adaptation of innovations is particularly complex, requiring the right combination of local knowledge (often tacit and implicit) with expert knowledge (often more explicit and formalised), as well as the support of extensive networks.This paper analyses a number of innovation projects in several European rural areas, through the data collected via in-depth interviews. It examines the projects' contributions and the role played by stakeholders in each stage of the projects. On the one hand, some findings suggest that innovation is particularly common in food production, as well as in the environmental and energy sectors. On the other hand, these projects tend to rely more heavily on large networks, in which the presence of public actors is often critical. © 2013 Elsevier Ltd. Source

Although evolution is a multifactorial process, theory posits that the speed of molecular evolution should be directly determined by the rate at which spontaneous mutations appear. To what extent these two biochemical and population-scale processes are related in nature, however, is largely unknown. Viruses are an ideal system for addressing this question because their evolution is fast enough to be observed in real time, and experimentally-determined mutation rates are abundant. This article provides statistically supported evidence that the mutation rate determines molecular evolution across all types of viruses. Properties of the viral genome such as its size and chemical composition are identified as major determinants of these rates. Furthermore, a quantitative analysis reveals that, as expected, evolution rates increase linearly with mutation rates for slowly mutating viruses. However, this relationship plateaus for fast mutating viruses. A model is proposed in which deleterious mutations impose an evolutionary speed limit and set an extinction threshold in nature. The model is consistent with data from replication kinetics, selection strength and chemical mutagenesis studies. © 2012 Rafael Sanjuán. Source

Rinaldi M.,University of Perugia | Scopetta S.,University of Perugia | Vento V.,University of Valencia
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

Double parton correlations, having effects on the double parton scattering processes occurring in high-energy hadron-hadron collisions, for example at the LHC, are studied in the valence quark region by means of constituent quark models. In this framework, two particle correlations are present without any additional prescription, at variance with what happens, for example, in independent particle models, such as the MIT bag model in its simplest version. From the present analysis, conclusions similar to the ones obtained recently in a modified version of the bag model can be drawn: correlations in the longitudinal momenta of the active quarks are found to be sizable, while those in transverse momentum are much smaller. However, the framework used allows us to understand clearly the dynamical origin of the correlations. In particular, it is shown that the small size of the correlations in transverse momentum is a model-dependent result, which would not occur if models with sizable quark orbital angular momentum were used to describe the proton. Our analysis permits us, therefore, to clarify the dynamical origin of the double parton correlations and to establish which, among the features of the results, are model independent. The possibility of testing the studied effects experimentally is discussed. © 2013 American Physical Society. Source

Olmo G.J.,University of Valencia | Rubiera-Garcia D.,Federal University of Paraiba
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

We study the field equations of extensions of general relativity formulated within a metric-affine formalism setting torsion to zero (Palatini approach). We find that different (second-order) dynamical equations arise depending on whether torsion is set to zero (i) a priori or (ii) a posteriori, i.e., before or after considering variations of the action. Considering a generic family of Ricci-squared theories, we show that in both cases the connection can be decomposed as the sum of a Levi-Cività connection and terms depending on a vector field. However, while in case (i) this vector field is related to the symmetric part of the connection, in (ii) it comes from the torsion part and, therefore, it vanishes once torsion is completely removed. Moreover, the vanishing of this torsion-related vector field immediately implies the vanishing of the antisymmetric part of the Ricci tensor, which therefore plays no role in the dynamics. Related to this, we find that the Levi-Cività part of the connection is due to the existence of an invariant volume associated with an auxiliary metric hμν, which is algebraically related with the physical metric gμν. © 2013 American Physical Society. Source

Kar P.,University of Calcutta | Haldar R.,Jawaharlal Nehru Centre for Advanced Scientific Research | Gomez-Garcia C.J.,University of Valencia | Ghosh A.,University of Calcutta
Inorganic Chemistry | Year: 2012

A multifunctional porous metal organic framework based on mixed-valence hexa-nuclear [Mn III 2Mn II 4O 2(pyz) 2(C 6H 5CH 2COO) 10] (pyz = pyrazine) units has been synthesized. The complex has been characterized by elemental analysis, IR spectroscopy, single-crystal X-ray diffraction analysis, and variable-temperature magnetic measurements. The structural analysis reveals that the bidentate pyz molecules connect each [Mn 6] unit to its four [Mn 6] neighbors through the peripheral Mn(II) centers, giving rise to a three-dimensional (3D) distorted diamond-like porous framework. Variable-temperature (2-300 K) magnetic susceptibility measurements show the presence of dominant antiferromagnetic interactions within the discrete [Mn 6] cluster that have been fitted with a model containing three exchange constants developed for the complex (J 1 = -8.6 cm -1, J 2 = -3.9 cm -1, and J 3 = -100.0 cm -1). Using 3,5-di-tert-butyl catechol (3,5-DTBC) as the substrate, catecholase activity of the complex has been studied; the turn over number is determined to be of 2547 h -1 in acetonitrile. This porous compound shows remarkable selectivity for adsorption of CO 2 over N 2 that may be correlated with the effect of window flexibility of the pore to the corresponding adsorbate molecules. © 2012 American Chemical Society. Source

Camarasa-Belmonte A.M.,University of Valencia
Journal of Hydrology | Year: 2016

Ephemeral streams are typical Mediterranean fluvial systems with high risk of flash flooding, and few data are available about these systems in most locales. However, the SAIH network (Automatic Hydrological Information Systems) of the Jucar River Water Authority has been providing detailed information about ephemeral streams in Spain every 5min since 1988. Using these data, we evaluated the processes of rainfall-runoff conversion and flood generation in five Mediterranean ephemeral streams ranging in size from 25 to 450km2. To provide a general framework for hydrological analysis, the study included 142 flash flood events registered between 1989 and 2007. A more detailed analysis was conducted for the Carraixet Basin under the dry antecedent moisture condition (AMC I) to evaluate the influence of rainfall on the basin's response. A simple index called Momentum of Maximum Intensity (MMI) was developed to describe the influence of rainfall intensity on hydrograph. Correlations between the main indicators of precipitation and flow also were assessed. Results showed that flash floods were generally generated by average accumulated rainfall of around 100mm at high intensities that could exceed 300mm/h. Initial abstractions and average water losses during the rainfall-runoff conversion processes were very important (runoff coefficients of 6% and runoff thresholds of 62mm). No correlation was found between initial abstractions (Ia ) calculated from the basin characteristics and runoff thresholds (P 0) empirically obtained, which create some doubts about the validity of Ia method for predicting floods in ephemeral streams. Accumulated rainfall was very important for flood volume, peak flow and water balance indicators, whereas intensity indicators were more related to the response times of the basins. Rainfall intensity variables influenced lag time. Accumulated rainfall, in combination with high reduced mean intensity and low persistence, were a good predictor for high peak flow. Finally, the analysis revealed two types of events. The first type, typical of summer and early autumn, consists of fast events characterized by intense rainfall concentrated at the beginning of the storm and high values of persistence and irregularity. The basin responds quickly and generates hydrographs that resemble the pattern of rain. The second type, representative of winter and spring, corresponds to less intense events. Although they accumulate more rain, maximum intensities are lower and occur at the end of the episode. The response of the basin is late, and hydrographs are quite different from hyetographs and very influenced by the basin. © 2016 Elsevier B.V. Source

Garcia-Morales V.,TU Munich | Garcia-Morales V.,University of Valencia
Physica A: Statistical Mechanics and its Applications | Year: 2015

Substitution systems evolve in time by generating sequences of symbols from a finite alphabet: At a certain iteration step, the existing symbols are systematically replaced by blocks of Nk symbols also within the alphabet (with Nk, a natural number, being the length of the kth block of the substitution). The dynamics of these systems leads naturally to fractals and self-similarity. By using B-calculus (García-Morales, 2012) universal maps for deterministic substitution systems both of constant and non-constant length, are formulated in 1D. It is then shown how these systems can be put in direct correspondence with Tsallis entropy. A 'Second Law of Thermodynamics' is also proved for these systems in the asymptotic limit of large words. © 2015 Elsevier B.V. All rights reserved. Source

Aguilar A.C.,Federal University of ABC | Binosi D.,European Center for Theoretical Studies in Nuclear Physics and Related Areas | Papavassiliou J.,University of Valencia
Journal of High Energy Physics | Year: 2010

We use recent lattice data on the gluon and ghost propagators, as well as the Kugo-Ojima function, in order to extract the non-perturbative behavior of two particular definitions of the QCD effective charge, one based on the pinch technique construction, and one obtained from the standard ghost-gluon vertex. The construction relies crucially on the definition of two dimensionful quantities, which are invariant under the renormalization group, and are built out of very particular combinations of the aforementioned Green's functions. The main non-perturbative feature of both effective charges, encoded in the infrared finiteness of the gluon propagator and ghost dressing function used in their definition, is the freezing at a common finite (non-vanishing) value, in agreement with a plethora of theoretical and phenomenological expectations. We discuss the sizable discrepancy between the freezing values obtained from the present lattice analysis and the corresponding estimates derived from several phenomenological studies, and attribute its origin to the difference in the gauges employed. A particular toy calculation suggests that the modifications induced to the non-perturbative gluon propagator by the gauge choice may indeed account for the observed deviation of the freezing values. © SISSA 2010. Source

Kondapalli L.A.,University of Colorado at Denver | Perales-Puchalt A.,University of Valencia
Fertility and Sterility | Year: 2013

Since 1978, we have witnessed a successful evolution of assisted reproductive technology (ART), with improvement of the pregnancy rates and a growing demand. However, in recent years, there has been increasing concern regarding its safety due to the potential health impact on its infants. The raise of the developmental origins of adult disease has positioned low birth weight (LBW) as a significant health issue. Although multiple studies have associated ART with LBW, the etiology of this association remains largely unknown. We review the potential association between different components of ART and infertility with LBW, while acknowledging the limitations of interpretation of the existing literature. Source

Cirigliano V.,Los Alamos National Laboratory | Jenkins J.P.,Los Alamos National Laboratory | Gonzalez-Alonso M.,Los Alamos National Laboratory | Gonzalez-Alonso M.,University of Valencia
Nuclear Physics B | Year: 2010

We describe non-standard contributions to semileptonic processes in a model independent way in terms of an SU (2)L × U (1)Y invariant effective lagrangian at the weak scale, from which we derive the low-energy effective lagrangian governing muon and beta decays. We find that the deviation from Cabibbo universality, ΔCKM ≡ | Vu d |2 + | Vu s |2 + | Vu b |2 - 1, receives contributions from four effective operators. The phenomenological bound ΔCKM = (- 1 ± 6) × 10- 4 provides strong constraints on all four operators, corresponding to an effective scale Λ > 11 TeV (90% CL). Depending on the operator, this constraint is at the same level or better then the Z pole observables. Conversely, precision electroweak constraints alone would allow universality violations as large as ΔCKM = - 0.01 (90% CL). An observed ΔCKM ≠ 0 at this level could be explained in terms of a single four-fermion operator which is relatively poorly constrained by electroweak precision measurements. © 2009 Elsevier B.V. All rights reserved. Source

De Azcarraga J.A.,University of Valencia | Izquierdo J.M.,University of Valladolid
Journal of Physics A: Mathematical and Theoretical | Year: 2010

This paper reviews the properties and applications of certain n-ary generalizations of Lie algebras in a self-contained and unified way. These generalizations are algebraic structures in which the two-entry Lie bracket has been replaced by a bracket with n entries. Each type of n-ary bracket satisfies a specific characteristic identity which plays the role of the Jacobi identity for Lie algebras. Particular attention will be paid to generalized Lie algebras, which are defined by even multibrackets obtained by antisymmetrizing the associative products of its n components and that satisfy the generalized Jacobi identity, and to Filippov (or n-Lie) algebras, which are defined by fully antisymmetric n-brackets that satisfy the Filippov identity. 3-Lie algebras have surfaced recently in multi-brane theory in the context of the Bagger-Lambert-Gustavsson model. As a result, Filippov algebras will be discussed at length, including the cohomology complexes that govern their central extensions and their deformations (it turns out that Whitehead's lemma extends to all semisimple n-Lie algebras). When the skewsymmetry of the Lie or n-Lie algebra bracket is relaxed, one is led to a more general type of n-algebras, the n-Leibniz algebras. These will be discussed as well, since they underlie the cohomological properties of n-Lie algebras. The standard Poisson structure may also be extended to the n-ary case. We shall review here the even generalized Poisson structures, whose generalized Jacobi identity reproduces the pattern of the generalized Lie algebras, and the Nambu-Poisson structures, which satisfy the Filippov identity and determine Filippov algebras. Finally, the recent work of Bagger-Lambert and Gustavsson on superconformal Chern-Simons theory will be briefly discussed. Emphasis will be made on the appearance of the 3-Lie algebra structure and on why the A4 model may be formulated in terms of an ordinary Lie algebra, and on its Nambu bracket generalization. © 2010 IOP Publishing Ltd. Source

Maestre-Ferrin L.,University of Valencia
The International journal of oral & maxillofacial implants | Year: 2011

To assess the prevalence of radiographic signs of maxillary sinus pathology in patients undergoing dental implant treatment and to compare the efficacy of panoramic radiography, computed tomography (CT), and three-dimensional (3D) CT with Implametric software in the diagnosis of sinus pathology. Thirty patients were selected at random from those being treatment-planned to receive implant-supported restorations in the maxilla and who had a panoramic radiograph, a conventional CT scan in acetate, and a 3D CT scan in digital format. The radiographic maxillary sinus findings were categorized as: (1) no sign of pathology, (2) mucosal thickening, (3) mucous cyst, or (4) occupation of the entire sinus. Seventeen women and 13 men were included, with a mean age of 50.9 years. There was a 38.3% prevalence of radiographic abnormalities (23.3% mucosal thickenings, 10% mucous cysts, and 5% occupation of the entire sinus). Of the 23 sinuses that displayed radiographic signs of pathology, only 1 (4.3%) was correctly diagnosed by the panoramic radiograph. The most common radiographic maxillary sinus finding was mucosal thickening, followed by mucous cysts and occupation of the whole sinus. Conventional CT can be considered a reliable method for the diagnosis of maxillary sinus pathology. Source

Botella F.J.,University of Valencia | Branco G.C.,University of Lisbon | Rebelo M.N.,University of Lisbon
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2010

We propose an extension of the hypothesis of Minimal Flavour Violation (MFV) to general multi-Higgs models without the assumption of Natural Flavour Conservation (NFC) in the Higgs sector. We study in detail under what conditions the neutral Higgs couplings are only functions of VCKM and propose a MFV expansion for the neutral Higgs couplings to fermions. © 2010 Elsevier B.V. All rights reserved. Source

Sanchis-Gomar F.,University of Valencia | Lippi G.,Clinical Chemistry and Haematology Laboratory
Journal of Strength and Conditioning Research | Year: 2012

The World Antidoping Agency (WADA) has introduced some changes in the 2012 prohibited list. Among the leading innovations to the rules are that both 5-aminoimidazole-4-carboxamide-1-b-D-ribofuranoside (peroxisome proliferator-activated receptor-d [PPAR-d]-5' adenosine monophosphate-activated protein kinase [AMPK] agonist) and GW1516 (PPAR-d-agonist) are no longer categorized as gene doping substances in the new 2012 prohibited list but as metabolic modulators in the class "Hormone and metabolic modulators." This may also be valid for the angotensin II receptor blocker telmisartan. It has recently been shown that telmisartan might induce similar biochemical, biological, and metabolic changes (e.g., mitochondrial biogenesis and changes in skeletal muscle fiber type) as those reported for the former call of substances. We suspect that metabolic modulators abuse such as telmisartan might become a tangible threat in sports and should be thereby targeted as an important antidoping issue. The 2012 WADA prohibited list does not provide telmisartan for a potential doping drug, but arguments supporting the consideration to include them among "metabolic modulators" are at hand. © 2012 National Strength and Conditioning Association. Source

Bierenbaum I.,University of Valencia
Nuclear Physics B - Proceedings Supplements | Year: 2010

We present an extension of the duality theorem, previously defined by S. Catani et al on the one-loop level, to higher loop orders. The duality theorem provides a relation between loop integrals and tree-level phase-space integrals. Here, the one-loop relation is rederived in a way which is more suitable for its extension to higher loop orders. This is shown in detail by considering the two-loop N-leg master diagram and by a short discussion of the four master diagrams at three loops, in this sketching the general structure of the duality theorem at even higher loop orders. © 2010 Elsevier B.V. Source

Jimenez-Vicente J.,University of Granada | Mediavilla E.,Institute of Astrophysics of Canarias | Mediavilla E.,University of La Laguna | Munoz J.A.,University of Valencia | Kochanek C.S.,Ohio State University
Astrophysical Journal | Year: 2012

Using microlensing measurements for a sample of 27 image pairs of 19 lensed quasars we determine a maximum likelihood estimate for the accretion disk size of an average quasar of rs = 4.0+2.4 - 3.1 lt-day at rest frame 〈λ〉 = 1736 Å for microlenses with a mean mass of 〈M〉 = 0.3 M. This value, in good agreement with previous results from smaller samples, is roughly a factor of five greater than the predictions of the standard thin disk model. The individual size estimates for the 19 quasars in our sample are also in excellent agreement with the results of the joint maximum likelihood analysis. © 2012. The American Astronomical Society. All rights reserved.. Source

Domingo L.R.,University of Valencia
Journal of the Chilean Chemical Society | Year: 2014

Two exhaustive topological analyses using the Electron Localisation Function (ELF) along the non-polar Diels-Alder reactions of 1,3-butadiene [J. Phys. Chem. A 107, 6014 (2003)] and cyclopentadiene [Org. Biomol. Chem. 8, 5495, (2010)] with ethylene established that the bonding changes along these reactions are non-concerted. Herein, the ELF bonding changes along the intramolecular Diels-Alder reaction of 1-(hex-5-enyl)cyclohexa-1,3-diene is analysed. The geometrical restrictions imposed by the tether break the synchronicity in the single bond formation in this non-polar reaction. The present ELF topological analysis along this intramolecular Diels-Alder reaction supports the earlier findings that established the non-concerted nature of Diels-Alder reactions. Source

Ezzati Nazhad Dolatabadi J.,Tabriz University of Medical Sciences | De La Guardia M.,University of Valencia
Analytical Methods | Year: 2014

A literature survey has been made of recent advances in the use of new nanomaterials for the biosensing of different biomolecules, which have opened new horizons in identifying and quantifying biomolecules, for possible early diagnosis of disease. Nanomaterials show similar dimensions to biomolecules like proteins (enzymes, antigens and antibodies) and DNA. The integration of nanomaterials with biomaterials results in novel hybrid nanobiomaterials with synergetic properties and functions. In this review, we will discuss recent progress in the field, describing the basic concepts of nanomaterial-based platforms for development and expansion of immunosensors and nanosensors. We present an overview of the various nanomaterial-based immunosensors that utilize different immune reagent recognition elements for nanomedical applications. © 2014 the Partner Organisations. Source

Badenes R.,University of Valencia
Current Opinion in Anaesthesiology | Year: 2016

PURPOSE OF REVIEW: This review reports recent evidence on intraoperative monitoring of cerebral oximetry and depth of anaesthesia during neuroanaesthesia procedures. RECENT FINDINGS: The clinical benefits of intraoperative monitoring with cerebral oximetry [near infrared spectroscopy (NIRS) and brain tissue oxygenation monitoring (brptiO2)] and depth of anaesthesia with bispectral index (BIS) have recently been studied in surgical (carotid endarterectomy, cerebral arteriovenous malformations resection and brain tumour resections) and neuroradiological vascular procedures. BrptiO2/PaO2 ratio is much more reliable than absolute brptiO2 readings in detecting hypoxia in arteriovenous malformation resections. NIRS can help clinicians monitor those patients receiving endovascular treatment for acute ischaemic stroke and during carotid endarterectomy, but the value of applying cerebral oximetry in patients with cerebral vasospasm needs to be further evaluated. Awake craniotomy demonstrated that because of considerable pharmacokinetic/pharmacodynamic interindividual variation, BIS titration is recommended. Thus, the presence of a frontal brain tumour did not affect ipsilateral BIS values. SUMMARY: Recent studies provide interesting evidence of intraoperative monitoring of NIRS, brptiO2 and BIS. The brptiO2/PaO2 ratio is much more reliable than an absolute brptiO2 reading; NIRS helps clinicians to monitor patients who are undergoing endovascular treatment, and BIS guides the titration of anaesthesia during awake craniotomy; its values are not affected by the presence of a frontal brain tumour. Copyright © 2016 YEAR Wolters Kluwer Health, Inc. All rights reserved. Source

Canales J.J.,University of Valencia
Behavioural Pharmacology | Year: 2010

The discovery that the addictive drugs impair neurogenesis in the adult hippocampus has prompted the elaboration of new biological hypotheses to explain addiction and drug-induced cognitive dysfunction. Considerable evidence now implicates the process of adult neurogenesis in at least some critical components of hippocampal-dependent memory function. In experimental models, psychomotor stimulant drugs produce alterations in the rate of birth, survival, maturation and functional integration of adult-born hippocampal neurons. Thus some of the deleterious consequences of drug abuse on memory could result from the neurotoxic actions of drugs on adult hippocampal neurogenesis. In this review, we will first summarize preclinical and clinical literature on the disruptive effects of drugs such as cocaine and ecstasy in the areas of learning, memory and attention. We will also summarize data that document the widespread effects of stimulant drugs on progenitor activity and precursor incorporation in the adult dentate gyrus. Finally, we will examine evidence that supports the involvement of hippocampal neurogenesis in specific aspects of learning and memory function and we will consider critically the hypothesis that some of the negative consequences of drug abuse on cognition might be ascribed to deficits in adult hippocampal neurogenesis. Evidence suggests that stimulant abuse impacts negatively on at least four areas of memory/cognitive function that may be influenced by adult hippocampal neurogenesis: contextual memory, spatial memory, working memory and cognitive flexibility. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. Source

Gonzalez M.A.,University of Valencia
Natural Product Reports | Year: 2015

Covering: 1980s-2014 In this study, the biological properties of natural abietane-type diterpenoids with an aromatic C ring are reviewed. An overview of the synthetic studies of this group of abietanes, including dehydroabietic acid, callitrisic acid and ferruginol, is presented. The review contains about 160 references. This journal is © The Royal Society of Chemistry. Source

Hawson S.T.,University of Valencia
Clinics in Podiatric Medicine and Surgery | Year: 2014

This article discusses physical therapy considerations after hallux valgus correction. Hallux valgus is a fairly common occurrence, and corrective surgery is an option when conservative measures fail. Symptoms such as pain, swelling, and difficulty walking may persist after surgical correction of bunion deformity that addresses soft tissue and bone structure. Physical therapy is helpful after corrective hallux valgus surgery to address impairments and continued dysfunction and to improve overall patient outcome expectations. This article describes the benefits of a multifaceted physical therapy program after hallux valgus correction. © 2014 Elsevier Inc. Source

Bernabeu J.,University of Valencia
Nuovo Cimento della Societa Italiana di Fisica C | Year: 2014

The conceptual basis for understanding the interplay of neutrino mass and mixing for neutrino oscillations were paradoxically discussed in a period when the prevailing view was that of massless neutrinos. The name of Bruno Pontecorvo is associated to most of the components for this beautiful quantum phenomenon: muon-electron universality, different neutrino flavours, mismatch between weak interaction and mass eigenstates, neutrino oscillation phenomenology, including flavour and Majorana transitions. © Società Italiana di Fisica. Source

Errandonea D.,University of Valencia
Physical Review B - Condensed Matter and Materials Physics | Year: 2013

Melting curves of Cu, Ni, Pd, and Pt were measured in a laser-heated diamond-anvil cell up to 43, 52, 28, and 28 GPa, respectively. The obtained results are compared with previous studies. In particular, the measurements made in Cu are in agreement with the literature. In Pt the experiments are consistent with Z method calculations indicating that earlier measurements probably underestimate the melting temperature of Pt at high pressure. Cu, Pd, and Pt show a qualitative similar melting behavior. In the case of Ni, experiments confirm that it has a low melting slope of 28 K/GPa. Ni is the only transition metal of groups 10 and 11 of the Periodic Table that shows such a slope since the other metals have a steeper melting slope of 41-47 K/GPa. The determined melting curves can be described with Simon equations which are reported. The present results increase the database on high-pressure melting and could contribute to improving the understanding of this phenomenon. © 2013 American Physical Society. Source

Fuster-Torres M.A.,University of Valencia
The International journal of oral & maxillofacial implants | Year: 2011

The aim of the present study was to determine bone density in designated implant sites using cone beam computed tomography (CBCT) and to evaluate possible correlations between age, gender, insertion torque measurements, and resonance frequency analysis (RFA) values. Completely and partially edentulous patients were treated with implants between 2007 and 2008 and evaluated retrospectively. The preoperative examination included a panoramic radiograph, CBCT, diagnostic casts, and a clinical examination of the jaws. With the CBCT scans, bone densities were recorded in Hounsfield units (HU). Insertion torque values and implant stability measurements (via RFA) were also noted. Mean bone density and insertion torque values were 623 ± 209 HU and 42.4 ± 4 Ncm, respectively, for the 82 implants placed. Mean primary stability (implant stability quotient) was 62.4 ± 8. The differences in mean bone density at implant sites in the mandible (717 ± 204 HU) and the maxilla (490 ± 128 HU) were statistically significant for all patients (P < .05). There was a statistically significant relationship between bone density values and insertion torque measurements for implant sites in the anterior mandible (r = 0.562, P < .05), as well as between bone density and RFA values for men (r = 0.412, P < .05). Bone density measurements using preoperative CBCT may be helpful as an objective diagnostic tool. These values, in conjunction with RFA values and insertion torque measurements, can provide the implant surgeon with an objective assessment of bone quality and may be especially useful where poor-quality bone is suspected. Source

Ruiz-Femenia P.,University of Valencia
Nuclear and Particle Physics Proceedings | Year: 2016

We discuss the calculation of Sommerfeld enhancements on the neutralino LSP relic abundance calculation for heavy neutralino dark matter including co-annihilations of nearly mass-degenerate neutralino and chargino states. A newly developed EFT framework enables us to consider for the first time all (off)-diagonal potential and annihilation matrices including P- and next-to-next-to-leading order S-wave effects for a generic MSSM parameter space point, and to treat effects from heavy states perturbatively. © 2015 Elsevier B.V. Source

Monrabal F.,University of Valencia
Nuclear and Particle Physics Proceedings | Year: 2016

The NEXT ββ0ν experiment will use a high-pressure gas electroluminescent TPC to search for the decay of Xe-136. The development, construction and installation of NEXT-WHITE (NEW), the first radio-pure version of NEXT, will take place this year at Laboratorio Subterráneo de Canfranc. NEW will run initially using 10 kg of natural xenon during which time NEXT technology will be validated and the topological reconstruction algorithms refined. Moreover, the background model will be benchmarked using data. A second run will use enriched xenon and will make a first measurement of the two neutrino channel (ββ2ν) by NEXT. This poster will present the various technical aspects of the detector detailing the radio-pure solutions for a low backgorund experiment and the low noise, high resolution measurement of both energy and position. © 2016. Source

Ilisie V.,University of Valencia
Nuclear and Particle Physics Proceedings | Year: 2016

After the discovery of a Standard Model-like boson with mass of about 125 GeV the possibility of an enlarged scalar sector arises naturally. Here we present the current status of the phenomenology of the two-Higgs-doublet models with a special focus on the charged Higgs sector. If one considers a fermiophobic charged Higgs (it does not couple to fermions at tree level), all present experimental bounds are evaded trivially, therefore one needs to consider other decay and production channels. In this work we also present some of the interesting features of this specific scenario. © 2015 Elsevier B.V. Source

Domingo-Pardo C.,University of Valencia
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | Year: 2016

A new method for measuring (n,γ) cross-sections aiming at enhanced signal-to-background ratio is presented. This new approach is based on the combination of the pulse-height weighting technique with a total energy detection system that features γ-ray imaging capability (i-TED). The latter allows one to exploit Compton imaging techniques to discriminate between true capture γ-rays arising from the sample under study and background γ-rays coming from contaminant neutron (prompt or delayed) captures in the surrounding environment. A general proof-of-concept detection system for this application is presented in this paper together with a description of the imaging method and a conceptual demonstration based on Monte Carlo simulations. © 2016 Elsevier B.V. All rights reserved. Source

Garcia-Morales V.,University of Valencia
EPL | Year: 2016

A minimalistic model for chimera states is presented. The model is a cellular automaton (CA) which depends on only one adjustable parameter, the range of the nonlocal coupling, and is built from elementary cellular automata and the majority (voting) rule. This suggests the universality of chimera-like behavior from a new point of view: Already simple CA rules based on the majority rule exhibit this behavior. After a short transient, we find chimera states for arbitrary initial conditions, the system spontaneously splitting into stable domains separated by static boundaries, some synchronously oscillating and the others incoherent. When the coupling range is local, nontrivial coherent structures with different periodicities are formed. Copyright © EPLA, 2016. Source

Perez A.,University of Valencia
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2016

We show that the Dirac quantum cellular automaton [A. Bisio, G. M. D'Ariano, and A. Tosini, Ann. Phys. (N.Y.) 354, 244 (2015)APNYA60003-491610.1016/j.aop.2014.12.016] shares many properties in common with the discrete-time quantum walk. These similarities can be exploited to study the automaton as a unitary process that takes place at regular time steps on a one-dimensional lattice, in the spirit of general quantum cellular automata. In this way, it becomes an alternative to the quantum walk, with a dispersion relation that can be controlled by a parameter that plays a similar role to the coin angle in the quantum walk. The Dirac Hamiltonian is recovered under a suitable limit. We provide two independent analytical approximations to the long-term probability distribution. It is shown that, starting from localized conditions, the asymptotic value of the entropy of entanglement between internal and motional degrees of freedom overcomes the known limit that is approached by the quantum walk for the same initial conditions and is similar to the ones achieved by highly localized states of the Dirac equation. © 2016 American Physical Society. Source

Gomez-Cadenas J.J.,University of Valencia
Nuclear and Particle Physics Proceedings | Year: 2016

NEXT (Neutrino Experiment with a Xenon TPC) is an experiment to search neutrinoless double beta decay processes (ββ0ν). The isotope chosen by NEXT is 136Xe. The NEXT technology is based in the use of time projection chambers operating at a typical pressure of 15 bar and using electroluminescence to amplify the signal (HPXe). The main advantages of the experimental technique are: a) excellent energy resolution; b) the ability to reconstruct the trajectory of the two electrons emitted in the decays, a unique feature of the HPXe which further contributes to the suppression of backgrounds; c) scalability to large masses; and d) the possibility to reduce the background to negligible levels thanks to the barium tagging technology (BaTa). The NEXT roadmap was designed in four stages: i) Demonstration of the HPX. e technology with prototypes deploying a mass of natural xenon in the range of 1 kg; ii) Characterisation of the backgrounds to the ββ0ν signal and measurement of the ββ2ν signal with the NEW detector, deploying 10 kg of enriched xenon and operating at the LSC; iii) Search for ββ0ν decays with the NEXT-100 detector, which deploys 100 kg of enriched xenon; iv) Search for ββ0ν decays with the BEXT detector, which will deploy masses in the range of the ton and will introduce two additional handles, only possible in a HPXe: a) A magnetic field, capable of further enhancing the topological signal of NEXT; and b) barium-tagging (a technique pioneered by the EXO experiment which is also accessible to NEXT). The first stage of NEXT has been successfully completed during the period 2009-2013. The prototypes NEXT-DEMO (IFIC) and NEXT-DBDM (Berkeley) were built and operated for more than two years. These apparatuses have demonstrated the main features of the technology. The experiment is currently developing its second phase. The NEW detector is being constructed during 2014 and will operate in the LSC during 2015. The NEXT-100 detector will be built and commissioned during 2016 and 2017 and will start data taking in 2018. NEXT-100 could discover ββ0ν processes if the period of the decay is equal or less than 6×1025 year. The fourth phase of the experiment (BEXT) could start in 2020. © 2015 Elsevier B.V. Source

Rojas A.D.,University of Valencia
Nuclear and Particle Physics Proceedings | Year: 2016

Assuming that the neutrino mass matrix is diagonalized by the TBM, we looked for the charged lepton mass matrix textures which render a lepton mixing matrix consistent with data. We were interested in the textures with the maximum number of zeros, so, we explored the cases of real matrices with three (and also four zeros) and found which of them provide solutions in agreement with data. We present the successful Yukawa textures and obtained the relative sizes of their non-zero entries. We found some interesting relations among the entries of these textures in terms of the charged lepton masses. Complete details can be found in [1]. © 2015 Elsevier B.V. Source

Pich A.,University of Valencia
Nuclear and Particle Physics Proceedings | Year: 2016

A brief overview of the main highlights discussed at ICHEP 2014 is presented. The experimental data confirm that the scalar boson discovered at the LHC couples to other particles as predicted in the Standard Model. This constitutes a great success of the present theoretical paradigm, which has been confirmed as the correct description at the electroweak scale. At the same time, the negative searches for signals of new phenomena tightly constrain many new-physics scenarios, challenging previous theoretical wisdom and opening new perspectives in fundamental physics. Fresh ideas are needed to face the many pending questions unanswered within the Standard Model framework. © 2015 Elsevier B.V. Source

Kekic M.,University of Valencia
Nuclear and Particle Physics Proceedings | Year: 2016

Within the framework of low-scale Type I seesaw models with two and three extra sterile neutrinos we evaluate the production of the sterile states in the Early Universe. We explore the full parameter space and find that in the model with two extra states both of them reach thermal equilibrium with the primordial plasma. In the model with three sterile neutrinos, if the lightest active neutrino mass is below O(10-3eV) one sterile neutrino might not thermalize, while the other two always reach thermalization. Applying constrains from both extra radiation at BBN and CMB, and the dark matter allowed abundance, we show that the spectra of heavier states are severely restricted in the mass range 1eV-100MeV. The possible impact of extra sterile neutrinos on neutrinoless double beta decay is also discussed. © 2015 Elsevier B.V. Source

Fiorini L.,University of Valencia
Nuclear and Particle Physics Proceedings | Year: 2016

Events containing several leptons are useful probes of new phenomena due to the low background from Standard Model processes. We look for events with three or more leptons, as well as direct searches for WZ resonances, excited leptons and heavy fermions. The searches use data recorded in 2012 at √s=8 TeV centre-of-mass energy by the ATLAS experiment at the LHC. No evidence of excess above the Standard Model background predictions was observed and limits have been set accordingly. © 2016. Source

Racker J.,University of Valencia
Nuclear and Particle Physics Proceedings | Year: 2016

This is a very short review on different mechanisms for baryogenesis from particle decays or annihilations at low temperature (T ≲ 10TeV) and their implementation in models that relate the origin of the baryon asymmetry and dark matter. © 2015 Elsevier B.V. Source

Bosch C.,University of Valencia
Nuclear and Particle Physics Proceedings | Year: 2016

Current experimental constraints prove being enough to rule out the possibility of the mh~125 GeV Higgs found at LHC being a heavy Higgs in a general MSSM context, even with explicit CP violation in the Higgs potential. Differently than what has been done in prior studies, we perform this job analitically, with expressions related to a few observables. Te relevance of ττ production through Higgs and BR(B→Xsγ) processes is emphasized, since they are enough to erase the possibility of finding an MSSM neutral Higgs lighter than the scalar discovered at LHC. © 2015 Elsevier B.V. Source

Domenech-Carbo A.,University of Valencia
Mechanics Research Communications | Year: 2013

A redefinition of the coefficient of tangential restitution based on the separation of friction and restitution effects is presented. Using this modified coefficient of tangential restitution and the usual definitions of the coefficients of normal restitution and sliding friction, a description of oblique impacts in both stick and slip regimes is obtained. This, description, which is tested with available rebound data in literature, avoids sharp (apparent) variations in the coefficient tangential restitution with impact angle and can justify anomalous results reported by Calsamiglia et al. (1999). © 2013 Elsevier Ltd. Source

Cros A.,University of Valencia
Physica Status Solidi - Rapid Research Letters | Year: 2013

Raman spectroscopy is becoming a standard method for the non-destructive characterization of nanowires and their heterostructures due to its ability to deliver information about size, structure, carrier concentration, local density, strain and orientation. Several phenomena related to vibrations and the anisotropic nature of nanowires have been reported. The so called "Raman antenna effect" leads to an increase of the scattering intensity that depends on nanowire size, orientation and excitation wavelength. Surface related vibrational modes have been proved to be sensitive to nanowire dimensions and their dielectric environment. Interface and confined modes characteristic of nanowire heterostructures have also been reported, together with low frequency modes that involve the vibration of the nanowire as a whole. Resonant inelastic light scattering has demonstrated its capability of providing information about the internal structure of individual nanowires and nanowire ensembles, increasing at the same time the Raman scattering efficiency. Furthermore, the coupling of the phonons with real electronic excitations gives access to band structure characteristics that cannot be accessed by other means. In this review we analyse the most recent advances concerning the vibrational properties of nanowire ensembles and single nanowires, paying special attention to their potential applications. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

Cantarero A.,University of Valencia
Journal of Nanophotonics | Year: 2013

Raman scattering is a nondestructive technique that is able to supply information on the crystal and electronic structures, strain, temperature, phonon-phonon, and electron-phonon interaction. In the particular case of semiconductor nanowires, Raman scattering provides additional information related to surfaces. Although correct, a theoretical approach to analyze the surface optical modes loses critical information when retardation is neglected. A comparison of the retarded and unretarded approaches clarifies the role of the electric and magnetic polarization in the Raman selection rules. Since most III-V compounds growing in the zincblende phase change their crystal structure to wurtzite when growing as nanowires, the polariton description will be particularized for these two important crystal phases. Confined phonons exist in cylindrical nanowires and couple with longitudinal and transverse modes due to the presence of the nanowire's surface. This coupling vanishes in the case of rotational symmetry. The boundary conditions of the electromagnetic fields on small-size nanowires (antenna effect) have a dramatic effect on the polarization properties of a Raman spectrum. © 2013 Society of Photo-Optical Instrumentation Engineers. Source

The identification of possible factors that are influencing the course of attention-deficit hyperactivity disorder (ADHD) will allow the development of more effective early intervention strategies. AIMS. This research, which used a longitudinal and correlational design, set out to examine the temporal consistency of the primary symptoms and ADHD associated problems. In addition, the relationships and predictive power of working memory, inhibition and stressful characteristics of children with ADHD on the disorder symptoms and behavioral problems in adolescence was analyzed. This study included 65 families with children diagnosed with ADHD. In phase 1 children performed verbal working memory, visuo-spatial and inhibition tests, and information from parents about stressful characteristics of children was collected. In phase 1 and in the follow-up phase, which took place three years later, parents and teachers reported on the primary symptoms of ADHD and behavioral problems. Inattention symptoms as well as most behavioral problems were stable over time, while hyperactivity/impulsivity symptoms decreased. Moreover, neither working memory nor inhibition showed power to predict the central manifestations of ADHD or behavioral problems, while stressful characteristics of demandingness, low adaptability and negative mood had a moderate predictive capacity. These results confirm the role of stressful child characteristics as a risk factor in the course of ADHD. Source

Ramajo-Hernandez J.,University of Extremadura | del Saz-Salazar S.,University of Valencia
Environmental Science and Policy | Year: 2012

This article addresses an important topic related to the application of the European Water Framework Directive (WFD) in Spanish watersheds. Results on a contingent valuation study, aimed to assess the non-market benefits of water quality improvements in the Guadiana river basin (GRB), are shown. Special attention has been paid to the issue of zero willingness-to-pay (WTP) responses, while addressing the possible presence of self-selection caused by protest responses. The results (i) indicate that sample selection bias is not a problem in our application, (ii) allow us to identify some key determinants of voting behaviour, and (iii) through the use of different econometric models allows us to find a robust estimate for the mean WTP to accurately inform decision-making. © 2012 Elsevier Ltd. Source

Arenas-Garcia J.,Charles III University of Madrid | Petersen K.B.,SAS | Camps-Valls G.,University of Valencia | Hansen L.K.,Technical University of Denmark
IEEE Signal Processing Magazine | Year: 2013

Feature extraction and dimensionality reduction are important tasks in many fields of science dealing with signal processing and analysis. The relevance of these techniques is increasing as current sensory devices are developed with ever higher resolution, and problems involving multimodal data sources become more common. A plethora of feature extraction methods are available in the literature collectively grouped under the field of multivariate analysis (MVA). This article provides a uniform treatment of several methods: principal component analysis (PCA), partial least squares (PLS), canonical correlation analysis (CCA), and orthonormalized PLS (OPLS), as well as their nonlinear extensions derived by means of the theory of reproducing kernel Hilbert spaces (RKHSs). We also review their connections to other methods for classification and statistical dependence estimation and introduce some recent developments to deal with the extreme cases of large-scale and low-sized problems. To illustrate the wide applicability of these methods in both classification and regression problems, we analyze their performance in a benchmark of publicly available data sets and pay special attention to specific real applications involving audio processing for music genre prediction and hyperspectral satellite image processing for Earth and climate monitoring. © 1991-2012 IEEE. Source

Papavassiliou J.,University of Valencia
Few-Body Systems | Year: 2016

The form of the kernel that controls the dynamics of the Bethe–Salpeter equations is essential for obtaining quantitatively accurate predictions for the observable properties of hadrons. In the present work we briefly review the basic physical concepts and field-theoretic techniques employed in a first-principle derivation of a universal (process-independent) component of this kernel. This “top-down” approach combines nonperturbative ingredients obtained from lattice simulations and Dyson–Schwinger equations, and furnishes a renormalization-group invariant quark-gluon interaction strength, which is in excellent agreement with the corresponding quantity obtained from a systematic “bottom-up” treatment, where bound-state data are fitted within a well-defined truncation scheme. © 2016, Springer-Verlag Wien. Source

Hezode C.,University Paris Est Creteil | Asselah T.,University Paris Diderot | Reddy K.R.,University of Pennsylvania | Hassanein T.,Southern California Liver Centers and Southern California Research Center | And 10 more authors.
The Lancet | Year: 2015

Summary Background Hepatitis C virus (HCV) genotype 4 accounts for about 13% of global HCV infections. Because interferon-containing treatments for genotype 4 infection have low efficacy and poor tolerability, an unmet need exists for effective all-oral regimens. We examined the efficacy and safety of an all-oral interferon-free regimen of ombitasvir, an NS5A inhibitor, and paritaprevir (ABT-450), an NS3/4A protease inhibitor dosed with ritonavir (ombitasvir plus paritaprevir plus ritonavir), given with or without ribavirin. Methods In this multicentre ongoing phase 2b, randomised, open-label combination trial (PEARL-I), patients were recruited from academic, public, and private hospitals and clinics in France, Hungary, Italy, Poland, Romania, Spain, Turkey, and the USA. Eligible participants were aged 18-70 years with non-cirrhotic, chronic HCV genotype 4 infection (documented ≥6 months before screening) and plasma HCV RNA levels higher than 10 000 IU/mL. Previously untreated (treatment-naive) patients were randomly assigned (1:1) by computer-generated randomisation lists to receive once-daily ombitasvir (25 mg) plus paritaprevir (150 mg) plus ritonavir (100 mg) with or without weight-based ribavirin for 12 weeks. Previously treated (treatment-experienced) patients who had received pegylated interferon plus ribavirin all received the ribavirin-containing regimen. The primary endpoint was a sustained virological response (HCV RNA <25 IU/mL) 12 weeks after the end of treatment (SVR12). Analysis was by intention to treat. This study is registered with ClinicalTrials.gov, number NCT01685203. Findings Between Aug 14, 2012, and Nov 19, 2013, 467 patients with HCV infection were screened, of whom 174 were infected with genotype 4. 135 patients were randomly assigned to treatment and received at least one dose of study medication; 86 patients were treatment-naive, of whom 44 received ombitasvir plus paritaprevir plus ritonavir and 42 received ombitasvir plus paritaprevir plus ritonavir with ribavirin, and 49 treatment-experienced patients received the ribavirin-containing regimen. In previously untreated patients, SVR12 rates were 100% (42/42 [95% CI 91·6-100]) in the ribavirin-containing regimen and 90·9% (40/44 [95% CI 78·3-97·5]) in the ribavirin-free regimen. No statistically significant differences in SVR12 rates were noted between the treatment-naive groups (mean difference -9·16% [95% CI -19·61 to 1·29]; p=0·086). All treatment-experienced patients achieved SVR12 (49/49; 100% [95% CI 92·7-100]). In the ribavirin-free group, two (5%) of 42 treatment-naive patients had virological relapse, and one (2%) of 44 had virological breakthrough; no virological failures were recorded in the ribavirin-containing regimen. The most common adverse event was headache (14 [29%] of 49 treatment-experienced patients and 14 [33%] of 42 treatment-naive patients). No adverse event-related discontinuations or dose interruptions of study medications, including ribavirin, were noted, and only four patients (4%) of 91 receiving ribavirin required dose modification for haemoglobin less than 100 g/L or anaemia. Interpretation An interferon-free regimen of ombitasvir plus paritaprevir plus ritonavir with or without ribavirin achieved high sustained virological response rates at 12 weeks after the end of treatment and was generally well tolerated, with low rates of anaemia and treatment discontinuation in non-cirrhotic previously untreated and previously treated patients with HCV genotype 4 infection. Funding AbbVie. © 2015 Elsevier Ltd. Source

Pich A.,University of Valencia
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | Year: 2016

The LHC data have confirmed the Standard Model as the correct theory at the electroweak scale. It successfully explains the experimental results with high precision and all its ingredients, including the Higgs boson, have been finally verified. At the same time, the negative searches for signals of new phenomena challenge our previous theoretical wisdom on new-physics scenarios. © 2015 Elsevier B.V. Source

Cerda Alberich L.,University of Valencia
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | Year: 2016

The performance of the central hadronic calorimeter, TileCal, in the ATLAS Experiment at the Large Hadron Collider is studied using cosmic-ray muons and the large sample of proton-proton collisions acquired during the Run 1 of LHC (2010-2012). Results are presented for the precision of the absolute energy scale and timing, noise characterization, and time-stability of the detector. The results show that the Tile Calorimeter performance is within the design requirements of the detector. © 2015 Elsevier B.V. Source

Ashrafi K.,Guilan University | Mas-Coma S.,University of Valencia
Veterinary Parasitology | Year: 2014

The lowland flatlands around the city of Bandar-Anzali, at the Caspian Sea shore, Guilan province, are an endemic area where Fasciola gigantica appears to be the fasciolid species involved and past outbreaks affecting around 15,000 people and the highest human infection rates in Iran have been reported. Fascioliasis transmission in that area has been experimentally analysed for the first time, by means of assays of monomiracidial (Group A: 120 snails) and pentamiracidial (Group B: 96 snails) infections of local Radix lymnaeid snails with a local cattle F. gigantica isolate. Ribosomal DNA ITS-2 sequencing proved that Lymnaea (Radix) gedrosiana should henceforth be considered a synonym of Radix auricularia, the haplotype found in Bandar-Anzali being identical to that found in many European countries. Survival rates at day 30 postinfection and metacercarial productivity (both higher in Group A) and longevity of the shedding snails (higher in Group B), were affected by the miracidial dose, whereas prepatent period, patent period, infection rate, and the percentages of shedding and infected non-shedding snails did not. The higher percentage of shedding snails in Group A (51.0% versus 37.7%) counteracts the higher number of metacercariae produced in Group B (243.9. ±. 259.2 versus 157.2. ±. 153.2). High numbers of shedding snails in both experimental groups passed less than 100 cercariae, and 16% in Group A and 35% in Group B produced more than 300 metacercariae, while only four snails (8%) in Group A and two snails (10%) in Group B shed more than 500 metacercariae. Most metacercariae (94.7% in Group A and 85.1% in Group B) were recorded during the first 15 days of patent period. The comparison with results from other fasciolid/lymnaeid systems indicates that the F. gigantica/. R. auricularia system of Guilan is highly susceptible and compatible. Results obtained suggest that increased lymnaeid vector populations and not polymiracidial snail infections most probably underlay the human outbreaks in the past. The climatic analyses suggest a long fascioliasis transmission period in the Bandar-Anzali area covering from May to the end of November regarding permanent water bodies, a transmission season window widening in rice fields and irrigation canals, and a shortening of the transmission period from only end of August to beginning of November in temporary water bodies. © 2014 Elsevier B.V. Source

Salgado J.,University of Valencia
Advances in Experimental Medicine and Biology | Year: 2010

Bilayer lipids, far from being passive elements, have multiple roles in polypeptide-dependent pore formation. Lipids participate at all stages of the formation of pores by providing the binding site for proteins and peptides, conditioning their active structure and modulating the molecular reorganization of the membrane complex. Such general functions of lipids superimpose to other particular roles, from electrostatic and curvature effects to more specific actions in cases like cholesterol, sphingolipids or cardiolipin. Pores are natural phenomena in lipid membranes. Driven by membrane fluctuations and packing defects, transient water pores are related to spontaneous lipid flip-flop and non-assisted ion permeation. In the absence of proteins or peptides, these are rare short living events, with properties dependent on the lipid composition of the membrane. Their frequency increases under conditions of internal membrane disturbance of the lipid packing, like in the presence of membrane-bound proteins or peptides. These latter molecules, in fact, form dynamic supramolecular assemblies together with the lipids and transmembrane pores are one of the possible structures of the complex. Active peptides and proteins can thus be considered inducers or enhancers of pores which increase their probability and lifetime by modifying the thermodynamic membrane balance. This includes destabilizing the membrane lamellar structure, lowering the activation energy for pore formation and stabilizing the open pore structure. © 2010 Landes Bioscience and Springer Science+Business Media. Source

Sarti V.M.,University of Ferrara | Vento V.,University of Valencia
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2014

The Chiral Dilaton Model, where baryons arise as non-topological solitons built from the interaction of quarks and chiral mesons, shows in the high density low temperature regime a two phase scenario in the nuclear matter phase diagram. Dense soliton matter described by the Wigner-Seitz approximation generates a periodic potential in terms of the sigma and pion fields that leads to the formation of a band structure. The analysis up to three times nuclear matter density shows that soliton matter undergoes two separate phase transitions: a delocalization of the baryon number density leading to B = 1/2 structures, as in skyrmion matter, at moderate densities, and quark deconfinement at larger densities. This description fits well into the so-called quarkyonic phase where, before deconfinement, nuclear matter should undergo structural changes involving the restoration of fundamental symmetries of QCD. © 2013 The Authors. Published by Elsevier B.V. Source

Navarro J.,University of Valencia | Polls A.,University of Barcelona
Physical Review C - Nuclear Physics | Year: 2013

We study the effects of the tensor force, present in modern effective nucleon-nucleon interactions, in the spin instability of nuclear and neutron matter. Stability conditions of the system against certain very low energy excitation modes are expressed in terms of Landau parameters. It is shown that in the spin case, the stability conditions are equivalent to the condition derived from the spin susceptibility, which is obtained as the zero-frequency and long-wavelength limit of the spin response function calculated in the random phase approximation. Zero-range forces of the Skyrme type and finite-range forces of M3Y and Gogny type are analyzed. It is shown that for the Skyrme forces considered, the tensor effects are sizable and tend to increase the spin instability, which appears at smaller densities than in the case that the tensor is not taken into account. On the contrary, the tensor contribution of finite-range forces to the spin susceptibility is small or negligible for both isospin channels of symmetric nuclear matter as well as for neutron matter. A comparison with the spin susceptibility provided by realistic interactions is also presented. © 2013 American Physical Society. Source

Roca L.,University of Murcia | Oset E.,University of Valencia
Physical Review C - Nuclear Physics | Year: 2013

We present a strategy to extract the position of the two Λ(1405) poles from experimental photoproduction data measured recently at different energies in the γp→K+π0Σ0 reaction at Jefferson Laboratory. By means of a chiral dynamics motivated potential with free parameters, we solve the Bethe-Salpeter equation in the coupled channels K̄N and πΣ in isospin I=0 and parametrize the amplitude for the photonuclear reaction in terms of a linear combination of the πΣ→πΣ and K̄N→πΣ scattering amplitudes in I=0, with a different linear combination for each energy. Good fits to the data are obtained with some sets of parameters, by means of which one can also predict the cross section for the K-p→π0Σ0 reaction. These later results help us decide among the possible solutions. The result is that the different solutions lead to two poles similar to those found in the chiral unitary approach. With the best result we find the two Λ(1405) poles at 1385-68iMeV and 1419-22iMeV. © 2013 American Physical Society. Source

Mondal A.,CNRS Paris Institute of Molecular Chemistry | Li Y.,CNRS Paris Institute of Molecular Chemistry | Seuleiman M.,CNRS Paris Institute of Molecular Chemistry | Julve M.,University of Valencia | And 3 more authors.
Journal of the American Chemical Society | Year: 2013

A repeatable bidirectional paramagnetic diamagnetic photomagnetic effect has been observed in the cyanide-bridged Fe-Co square complex {[Fe{B(pz) 4}(CN)3]2[Co(bik)2] 2}(ClO4)2·3H2O [B(pz) 4 = tetrapyrazolylborate, bik = bis(1-methylimidazol-2-yl)ketone]. Magnetic measurements and low-temperature single-crystal X-ray diffraction experiments have shown that a complete electron transfer from the diamagnetic FeII -Co III state to the paramagnetic FeIII -Co II metastable state is induced by 808 nm laser light irradiation, whereas the diamagnetic state is recovered in an almost quantitative yield under irradiation at 532 nm. © 2013 American Chemical Society. Source

Roca L.,University of Murcia | Oset E.,University of Valencia
Physical Review C - Nuclear Physics | Year: 2013

Recently we presented a successful strategy to extract the position of the two Λ(1405) poles from experimental photoproduction data on the γp→K+π0Σ0 reaction at Jefferson Lab. Following a similar strategy, we extend the previous method to incorporate also the isospin 1 component which allows us to consider in addition the experimental data on γp→K+π±Σ â̂". The idea is based on considering a production mechanism as model independent as possible and implementing the final state interaction of the final meson-baryon pair based on small modifications of the unitary chiral perturbation theory amplitudes. Good fits to the data are obtained with this procedure, by means of which we can also predict the cross sections for the K-p→K̄N, πΣ, and πΛ reactions for the different charge channels. Besides the two poles found for the Λ(1405) resonance, we discuss the possible existence of an isospin 1 resonance in the vicinity of the K̄N threshold. © 2013 American Physical Society. Source

Pena Cantero A.L.,University of Valencia
Polar Biology | Year: 2012

The Bellingshausen Sea constitutes the third largest sea in the Southern Ocean, though it is widely recognized as one of the less-studied Antarctic areas. To reduce this lack of knowledge, a survey to study the biodiversity of its marine benthic communities was carried out during the Bentart 2003 and Bentart 2006 Spanish Antarctic expeditions. The study of the hydroid collection has provided 27 species, belonging to ten families and 15 genera. Twenty-one out of the 27 species constitute new records for the Bellingshausen Sea, raising the total number of known species to 37, as also do nine out of the 15 genera. Candelabrum penola, Lafoea annulata, and Staurotheca juncea are recorded for the second time. Most species belong to Leptothecata. Sertulariidae with 13 species (48%) is by far the most speciose family, and Symplectoscyphus with seven species (26%), including S. bellingshauseni sp. nov. and S. hesperides sp. nov., the most diverse genus. Considering the whole benthic hydroid fauna of the Bellingshausen Sea, 18 species (69%) are endemic to Antarctic waters, either with a circum-Antarctic (12 species, 46%) or West Antarctic (6 species, 23%) distribution, 23 (88%) are restricted to Antarctic or Antarctic/sub-Antarctic waters, and only three species have a wider distribution. Bellingshausen Sea hydroid fauna is composed of a relatively high diversity of typical representatives of the Antarctic benthic hydroid fauna, though with a surprisingly low representation of some of the most diverse and widespread Antarctic genera (Oswaldella and Schizotricha), what could be related to the fact that its shelf-inhabiting hydroid fauna remains practically unknown. © 2011 Springer-Verlag. Source

Cascales-Minana B.,University of Valencia
Historical Biology | Year: 2012

By taking gymnosperms as a case study, this article evaluates the perception of plant life history from the fossil record to test the biases associated with the time-dependent aspects of the taxonomy, following a stepwise modelling procedure based on two divergent sets of time units. The idea that the effects of the temporal component of paleobiological inference need to be evaluated to remove any possible bias in our interpretation and perception of plant evolution based on analyses of large-scale data sets is investigated. The results reveal important differences in our perception of the tempo of gymnosperm evolution and how it is biased in terms of time unit length due to the loss of information as a consequence of the timescale resolution. Despite singletons representing real morphological diversity translated into independent taxonomic categories, these taxa can distort perceptions of the intensity of the long paleofloristic diversification moments of gymnosperms if their effect is not considered. This study shows a complete overview of the evolutionary profiles of gymnosperms with significant discrepancies in the function of how singletons are quantitatively processed in paleobotanical data analyses, and it provides new evidence about how the 'zoom effect' can magnify our perception of extinction events. © 2012 Copyright Taylor and Francis Group, LLC. Source

Pich A.,University of Valencia
Progress in Particle and Nuclear Physics | Year: 2014

Precise measurements of the lepton properties provide stringent tests of the Standard Model and accurate determinations of its parameters. We overview the present status of τ physics, highlighting the most recent developments, and discuss the prospects for future improvements. The leptonic decays of the τ lepton probe the structure of the weak currents and the universality of their couplings to the W boson. The universality of the leptonic Z couplings has also been tested through Z→ℓ+ℓ- decays. The hadronic τ decay modes constitute an ideal tool for studying low-energy effects of the strong interaction in very clean conditions. Accurate determinations of the QCD coupling and the Cabibbo mixing Vus have been obtained with τ data. The large mass of the τ opens the possibility to study many kinematically-allowed exclusive decay modes and extract relevant dynamical information. Violations of flavour and CP conservation laws can also be searched for with τ decays. Related subjects such as μ decays, the electron and muon anomalous magnetic moments, neutrino mixing and B-meson decays into τ leptons are briefly covered. Being one the fermions most strongly coupled to the scalar sector, the τ lepton is playing now a very important role at the LHC as a tool to test the Higgs properties and search for new physics at higher scales. © 2013 Elsevier B.V. All rights reserved. Source

De Valcarcel G.J.,University of Valencia | Staliunas K.,Polytechnic University of Catalonia
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2013

We study pattern formation in a passive nonlinear optical cavity on the basis of the classic Lugiato-Lefever model with a periodically modulated injection. When the injection amplitude sign alternates, e.g., following a sinusoidal modulation in time or in space, a phase-bistable response emerges, which is at the root of the spatial pattern formation in the system. An asymptotic description is given in terms of a damped nonlinear Schrödinger equation with parametric amplification, which allows gaining insight into the basic spatiotemporal dynamics of the system. One- and two-dimensional phase-bistable spatial patterns, such as bright and dark-ring cavity solitons and labyrinths, are demonstrated. © 2013 American Physical Society. Source

Hernandez-Rey J.J.,University of Valencia
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | Year: 2014

The KM3NeT Collaboration intends to build and operate a deep-sea research infrastructure that will host as its main facility a neutrino telescope of several cubic kilometres. The infrastructure will be distributed in three sites located near Toulon, France (40 km offshore and seabed at 2500 m), Capo Passero (80 km offshore and seabed at 3500 m) and Pylos, Greece (20 km offshore and seabed between 2500 and 5000 m). In this contribution we describe the technological choices made for the basic components of the three-dimensional array of photo-sensitive devices in which the telescope will consist. The Digital Optical Modules (DOMs) will use a 17 in. pressure-resistant sphere to accommodate 31 photomultipliers (PMTs) with a 3 in. photocathode each. These DOMs will be installed in detector units (DUs) consisting of vertical strings anchored to the seabed and kept taut by the appropriate buoyancy. These DUs will be deployed by means of launching vehicles that will allow several of them to be deployed in the same campaign. The main features of the telescope and its technical components, the science it can do and the recent progress made towards its construction will be described here. © 2013 Elsevier B.V. Source

The aim of the study was to identify predictors associated with a lower likelihood of achieving a clinical remission 1 year after the first break of the illness. Participants were 174 consecutive subjects included in a first episode programme with no prior treatment with antipsychotic medication. Patients were assigned to haloperidol, olanzapine or risperidone in a randomized, open-label, prospective clinical trial. The main outcome variable was the remission criteria developed by the Remission in Schizophrenia Working Group. Clinical variables were included in a logistic regression analysis in order to predict the remission state at 1 year. At 1 year, 31% of patients met criteria for remission. The logistic regression analysis revealed that the strongest predictors of achieving clinical remission 1 year away from a first episode of non-affective psychosis were the length of duration of untreated psychosis (DUP), the severity of negative symptomatology and the educational level attained at baseline. The results suggest that: (1) patients with a lengthy DUP, a greater severity of negative symptomatology at baseline and with a lower education level are in a higher risk of not achieving a clinical remission during the first year of treatment; and (2) early intervention clinical programs should aim to reduce the length of DUP in order to provide a better outcome for patients. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. Source

Lattanzi M.,University of Ferrara | Lineros R.A.,University of Valencia | Taoso M.,CEA Saclay Nuclear Research Center
New Journal of Physics | Year: 2014

The origin of neutrino masses and the nature of dark matter are two in most pressing open questions in modern astro-particle physics. We consider here the possibility that these two problems are related, and review some theoretical scenarios which offer common solutions. A simple possibility is that the dark matter particle emerges in minimal realizations of the seesaw mechanism, as in the majoron and sterile neutrino scenarios. We present the theoretical motivation for both models and discuss their phenomenology, confronting the predictions of these scenarios with cosmological and astrophysical observations. Finally, we discuss the possibility that the stability of dark matter originates from a flavor symmetry of the leptonic sector. We review a proposal based on an A4 flavor symmetry. © 2014 IOP Publishing Ltd and Deutsche Physikalische Gesellschaft. Source

Lucia O.,University of Zaragoza | Maussion P.,CNRS LAPLACE Lab | Dede E.J.,University of Valencia | Burdio J.M.,University of Zaragoza
IEEE Transactions on Industrial Electronics | Year: 2014

Induction heating (IH) technology is nowadays the heating technology of choice in many industrial, domestic, and medical applications due to its advantages regarding efficiency, fast heating, safety, cleanness, and accurate control. Advances in key technologies, i.e., power electronics, control techniques, and magnetic component design, have allowed the development of highly reliable and cost-effective systems, making this technology readily available and ubiquitous. This paper reviews IH technology summarizing the main milestones in its development and analyzing the current state of art of IH systems in industrial, domestic, and medical applications, paying special attention to the key enabling technologies involved. Finally, an overview of future research trends and challenges is given, highlighting the promising future of IH technology. © 2013 IEEE. Source

Perez-Escobar O.A.,Ludwig Maximilians University of Munich | Balbuena J.A.,University of Valencia | Gottschling M.,Ludwig Maximilians University of Munich
Systematic Biology | Year: 2016

Phylogenetic relationships inferred from multilocus organellar and nuclear DNA data are often difficult to resolve because of evolutionary conflicts among gene trees. However, conflicting or "outlier" associations (i.e., linked pairs of "operational terminal units" in two phylogenies) among these data sets often provide valuable information on evolutionary processes such as chloroplast capture following hybridization, incomplete lineage sorting, and horizontal gene transfer. Statistical tools that to date have been used in cophylogenetic studies only also have the potential to test for the degree of topological congruence between organellar and nuclear data sets and reliably detect outlier associations. Two distance-based methods, namely ParaFit and Procrustean Approach to Cophylogeny (PACo), were used in conjunction to detect those outliers contributing to conflicting phylogenies independently derived from chloroplast and nuclear sequence data. We explored their efficiency of retrieving outlier associations, and the impact of input data (unit branch length and additive trees) between data sets, by using several simulation approaches. To test their performance using real data sets, we additionally inferred thephylogenetic relationships withinNeotropical Catasetinae (Epidendroideae,Orchidaceae), whichis a suitable group to investigate phylogenetic incongruence because of hybridization processes between some of its constituent species. A comparison between trees derived from chloroplast and nuclear sequence data reflected strong, well-supported incongruence within Catasetum, Cycnoches, and Mormodes. As a result, outliers among chloroplast and nuclear data sets, and in experimental simulations, were successfully detected by PACo when using patristic distance matrices obtained from phylograms, but not fromunit branch length trees. The performance of ParaFitwas overall inferior compared to PACo, using either phylograms or unit branch lengths as input data. Because workflows for applying cophylogenetic analyses are not standardized yet, we provide a pipeline for executing PACo and ParaFit as well as displaying outlier associations in plots and trees by using the software R. The pipeline renders a method to identify outliers with high reliability and to assess the combinability of the independently derived data sets by means of statistical analyses. © The Author(s) 2015. Published by Oxford University Press, on behalf of the Society of Systematic Biologists. All rights reserved. Source

Ferrando A.,University of Valencia
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2014

Discrete-Gauss states are a new class of Gaussian solutions of the free Schrödinger equation owning discrete rotational symmetry. They are obtained by acting with a discrete deformation operator onto Laguerre-Gauss modes. We present a general analytical construction of these states and show the necessary and sufficient condition for them to host embedded dark beam structures. We unveil the intimate connection between discrete rotational symmetry, orbital angular momentum, and the generation of focusing dark beams. The distinguishing features of focusing dark beams are discussed. The potential applications of discrete-Gauss states in advanced optical trapping and quantum information processing are also briefly discussed. © 2014 American Physical Society. Source

Lanas A.,University of Zaragoza | Garcia-Tell G.,University of Valencia | Armada B.,Pfizer | Oteo-Alvaro A.,Service of Orthopedics
BMC Medicine | Year: 2011

Background: Prescription of non-steroidal anti-inflammatory drugs (NSAIDs) should be based on the assessment of both gastrointestinal (GI) and cardiovascular (CV) risk for the individual patient. We aimed to assess the GI/CV risk profile and the pharmacological management of patients with osteoarthritis (OA) in clinical practice.Methods: We conducted a cross-sectional, multicentre, observational study of consecutive OA patients that visited 1,760 doctors throughout the Spanish National Health System (NHS) in a single day. The presence of GI risk factors, CV histories, hypertension and current pharmacological treatments was recorded.Results: Of the 60,868 patients, 17,105 had a diagnosis of OA and were evaluable. The majority (93.4%) had more than one GI risk factor and 60.3% were defined to be at high-GI risk. Thirty-two percent had a history of CV events, 57.6% were treated with anti-hypertensive therapy and 22.6% had uncontrolled hypertension. One-fifth of patients were treated with non-NSAID therapies, whereas the remaining patients received NSAIDs. Non-selective NSAIDs (nsNSAID) plus proton pump inhibitor (PPI) or cyclooxigenase-2 (COX-2)-selective NSAIDs alone were more frequently prescribed in patients at increased GI risk. Patients with a positive CV history received nsNSAIDs or COX-2-selective NSAIDs in 41.3% and 31.7% of cases, respectively. When both the GI and CV histories were combined, 51% of the overall population was being prescribed drugs that were either not recommended or contraindicated.Conclusions: Over 90% of patients with OA are at increased GI and/or CV risk. In over half of these patients, the prescription of NSAIDs was not in accordance with current guidelines or recommendations made by regulatory agencies. © 2011 Lanas et al; licensee BioMed Central Ltd. Source

Dowlati M.,University of Valencia | de la Guardia M.,University of Valencia | Dowlati M.,University of Tehran | Mohtasebi S.S.,University of Tehran
TrAC - Trends in Analytical Chemistry | Year: 2012

Machine vision is a non-destructive, rapid, economic, consistent and objective inspection tool and is also an evaluation technique based on image analysis and processing with a variety of applications.We review the use of machine vision and imaging technologies for fish-quality assessment.This review updates and condenses a representative selection of recent research and industrial solutions proposed in order to evaluate the general trends of machine vision and image processing in the visible range applied for inspection of fish and fish products. In order to determine freshness and composition, it is necessary to measure and to evaluate size and volume, to estimate weight, to measure shape parameters, to analyze skin and fillet in different color shades, to recognize fish species and sex, and to detect defects.Considering the overall trends, we propose some future directions for research. © 2012 Elsevier Ltd. Source

Hasanzadeh M.,Tabriz University of Medical Sciences | Shadjou N.,Pasteur Institute of Iran | Eskandani M.,Tabriz University of Medical Sciences | Guardia M.,University of Valencia
TrAC - Trends in Analytical Chemistry | Year: 2012

Biology and medicine have seen great advancements in the development of enzyme nanobiosensors capable of characterizing and quantifying biomolecules.We provide an overview of mesoporous silica (MPS)-based enzyme nanobiosensors developed for biological and medical applications, and we describe significant advances in these technologies.We review progress in constructing high-performance electrochemical enzyme biosensors. We also discuss: •MCM-41 and SBA-15-modified and MPS composite electrodes for enzyme biosensing;•incorporation of biorecognition elements into MPS material electrodes for enzyme biosensing; and,•MCM-41 and SBA-15-supported electrocatalytic MPS-based electrochemical enzyme biosensors. © 2012 Elsevier Ltd. Source

This study reviews the trends in the lifestyle, habitat distribution and trophic diversity of the 2377 described species of dinoflagellates (Dinophyceae). Most of the dinoflagellates inhabit marine waters, whereas 17% of the total species have colonized continental waters. Dinoflagellates are dominated by planktonic species, while benthic forms represented 8% of the species. From the total number of species, 49% are heterotrophic (devoid of plastids), while 51% of the species have been reported with plastids (that does not strictly imply autotrophy). All the basal dinoflagellates (ellobiopsids, Duboscquodinida, Syndiniales) are heterotrophic, with the exception of a few Noctilucales (Spatulodinium). The continental waters are highly dominated by plastid-containing species (88%), while in marine environments there is a slight dominance of heterotrophic species (58%). Most of the dinoflagellates are free-living forms; only 7% of the total species are parasites. The dinokaryotic parasites appear in separate clades, and about 40% of them contain plastids. The beneficial or mutualistic symbionts (21 species, 1%) are photosynthetic species dispersed into at least three clades. © 2012 The Natural History Museum. Source

Liu B.-C.,Xian Jiaotong University | Xie J.-J.,Zhengzhou University | Xie J.-J.,University of Valencia
Physical Review C - Nuclear Physics | Year: 2012

We report on a theoretical study of the K -p→ηΛ reaction near threshold by using an effective Lagrangian approach. The role of s-channel Λ(1670), t-channel K *, and u-channel proton pole diagrams are considered. We show that the total cross section data are well reproduced. However, only including the s-wave Λ(1670) state and the background contribution from t and u channels is not enough to describe the bowl structures in the angular distribution of the K -p→ηΛ reaction, which indicates that there should be higher partial waves contributing to this reaction in some energy region. Indeed, if we considered the contributions from a D 03 resonance, we could describe the bowl structures; however, a rather small width (∼2 MeV) of this resonance would be needed. © 2012 American Physical Society. Source

Zapata-Rodriguez C.J.,University of Valencia | Naserpour M.,Shiraz University
Optics Letters | Year: 2014

Spatially accelerating beams that are solutions to Maxwell equations may propagate along incomplete circular trajectories. Taking these truncated Bessel fields to the paraxial limit, some authors have sustained that it has recovered the known Airy beams (AiBs). Based on the angular spectrum representation of optical fields, we demonstrated that the paraxial approximation rigorously leads to off-axis focused beams instead of finite-energy AiBs. The latter will arise under the umbrella of a nonparaxial approach following elliptical trajectories in place of parabolas. The analytical expression of such a shape-preserving wave field under Gaussian apodization is disclosed by using thirdorder nonparaxial coefficients. Deviations from full-wave simulations appear more severely in beam positioning rather than its local profile. © 2014 Optical Society of America. Source

Barry J.,Max Planck Institute for Nuclear Physics | Dorame L.,University of Valencia | Rodejohann W.,Max Planck Institute for Nuclear Physics
European Physical Journal C | Year: 2012

There are various diagrams leading to neutrinoless double beta decay in left-right symmetric theories based on the gauge group SU(2) L×SU(2) R. All can in principle be tested at a linear collider running in electron-electron mode. We argue that the so-called λ-diagram is the most promising one. Taking the current limit on this diagram from double beta decay experiments, we evaluate the relevant cross section ēē → W̄ L W̄ R, where W̄ L is the Standard Model W-boson and W̄ R the one from SU(2) R. It is observable if the life-time of double beta decay and the mass of the W R are close to current limits. Beam polarization effects and the high-energy behaviour of the cross section are also analyzed. © 2012 Springer-Verlag / Società Italiana di Fisica. Source

Vincent A.C.,University of Valencia | Scott P.,McGill University
Journal of Cosmology and Astroparticle Physics | Year: 2014

We use the formalism of Gould and Raffelt [1] to compute the dimensionless thermal conduction coefficients for scattering of dark matter particles with standard model nucleons via cross-sections that depend on the relative velocity or momentum exchanged between particles. Motivated by models invoked to reconcile various recent results in direct detection, we explicitly compute the conduction coefficients α and κ for cross-sections that go as v rel 2, vrel 4, vrel -2, q2, q4 and q-2, where v rel is the relative DM-nucleus velocity and q is the momentum transferred in the collision. We find that a vrel -2 dependence can significantly enhance energy transport from the inner solar core to the outer core. The same can true for any q-dependent coupling, if the dark matter mass lies within some specific range for each coupling. This effect can complement direct searches for dark matter; combining these results with state-of-the-art solar simulations should greatly increase sensitivity to certain DM models. It also seems possible that the so-called Solar Abundance Problem could be resolved by enhanced energy transport in the solar core due to such velocity- or momentum-dependent scatterings.©2014 IOP Publishing Ltd and Sissa Medialab srl. Source

Farzan Y.,Institute for Research in Fundamental Sciences | Palomares-Ruiz S.,University of Valencia
Journal of Cosmology and Astroparticle Physics | Year: 2014

Scalar (fermion) dark matter with mass in the MeV range coupled to ordinary neutrinos and another fermion (scalar) is motivated by scenarios that establish a link between radiatively generated neutrino masses and the dark matter relic density. With such a coupling, cosmic supernova neutrinos, on their way to us, could resonantly interact with the background dark matter particles, giving rise to a dip in their redshift-integrated spectra. Current and future neutrino detectors, such as Super-Kamiokande, LENA and Hyper-Kamiokande, could be able to detect this distortion. © 2014 IOP Publishing Ltd and Sissa Medialab srl. Source

Lopez-Moreno S.,National Autonomous University of Mexico | Errandonea D.,University of Valencia
Physical Review B - Condensed Matter and Materials Physics | Year: 2012

In this work we present a theoretical study of structural stability of CrVO 4-type orthophosphates InPO 4 and TiPO 4 at ambient and high pressures. Total energy calculations and lattice dynamics were used to obtain structural and vibrational properties of these compounds. Also, we have studied at ambient pressure the orthophosphates TlPO 4 and VPO 4 in order to compare their structural and vibrational properties with InPO 4 and TiPO 4. Here we analyze the variation of the Raman and IR frequencies as functions of the reduced mass. Using the phonon dispersion relations we have calculated the Gibbs free energy and evaluated the phase transitions at 300 K, at which most experimental measurements are performed. By taking into consideration the Bastide's diagram and previous theoretical and experimental studies in APO 4 compounds, we have considered 12 candidate structures for the high-pressure regime. We found the following sequence for pressure-driven structural transition: CrVO 4 type → zircon → scheelite → wolframite, for InPO 4 and TiPO 4. The equations of state, phonon frequencies, and their behavior with pressure of the most stable polymorphs are also reported. We also included the phonon spectrum and the projected phonon density of states of each phase for both compounds. Finally, calculation of the evolution of magnetic moment is reported for TiPO 4. © 2012 American Physical Society. Source

Gonzalez Felipe R.,Polytechnic Institute of Lisbon | Gonzalez Felipe R.,University of Lisbon | Serodio H.,University of Valencia
Nuclear Physics B | Year: 2014

In an attempt at explaining the observed neutrino mass-squared differences and leptonic mixing, lepton mass matrices with zero textures have been widely studied. In the weak basis where the charged lepton mass matrix is diagonal, various neutrino mass matrices with two zeros have been shown to be consistent with the current experimental data. Using the canonical and Smith normal form methods, we construct the minimal Abelian symmetry realizations of these phenomenological two-zero neutrino textures. The implementation of these symmetries in the context of the seesaw mechanism for Majorana neutrino masses is also discussed. © 2014 The Authors. Source

Vijande J.,University of Valencia | Valcarce A.,University of Salamanca
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2014

We present a plausible mechanism for the origin of the XYZ mesons in the heavy meson spectra within a standard quark-model picture. We discuss the conditions required for the existence of four-quark bound states or resonances contributing to the heavy meson spectra, being either compact or molecular. We concentrate on charmonium and bottomonium spectra, where several new states, difficult to understand as simple quark-antiquark pairs, have been reported by different experimental collaborations. The pivotal role played by entangled meson-meson thresholds is emphasized. © 2014 The Authors. Source

Pallis C.,University of Valencia | Shafi Q.,University of Delaware
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2014

Motivated by the reported discovery of inflationary gravity waves by the Bicep2 experiment, we propose an inflationary scenario in supergravity, based on the standard superpotential used in hybrid inflation. The new model yields a tensor-to-scalar ratio r ≃ 0.14 and scalar spectral index ns ≃ 0.964, corresponding to quadratic (chaotic) inflation. The important new ingredients are the high-scale, (1.6-10) {dot operator} 1013GeV, soft supersymmetry breaking mass for the gauge singlet inflaton field and a shift symmetry imposed on the Kähler potential. The end of inflation is accompanied, as in the earlier hybrid inflation models, by the breaking of a gauge symmetry at (1.2-7.1) {dot operator} 1016GeV, comparable to the grand-unification scale. © 2014 Elsevier B.V. Source

Bou-Franch P.,University of Valencia | Garces-Conejos Blitvich P.,University of North Carolina at Charlotte
Journal of Pragmatics | Year: 2014

The aim of this paper is to examine how conflict begins, unfolds and ends in a massive, new media polylogue, specifically, a YouTube polylogue. Extant research has looked into how conflict begins, unfolds and/or ends. However, to our knowledge, the models and taxonomies developed so far have not been applied to the analysis of the mediated conflict of massive polylogues. Drawing on the difference between methods of analysis that are natively digital versus those that have been digitized, i.e., they were developed for off-line research and then migrated on-line, one of the goals of this paper is to test whether non-natively digital, extant models and taxonomies, if digitized, would be well equipped to handle massive mediated polylogues. A multilayered methodology was devised and applied to the analysis of a sizeable corpus of comments triggered by a public service announcement on teen homosexuality posted by a Spanish LGBT association. Findings reveal that extant, models and taxonomies of conflict - developed to account mostly for local, synchronic, dyadic conflict -, if solely digitized, would not be well equipped to explain societal, diachronic, massively polylogal conflict such as the one under analysis and that hybrid models that can tackle the affordances of digital technologies need to be developed. © 2014 Elsevier B.V. Source

Olmo G.J.,University of Valencia | Rubiera-Garcia D.,Federal University of Paraiba
Journal of Cosmology and Astroparticle Physics | Year: 2014

We point out that in certain four-dimensional extensions of general relativity constructed within the Palatini formalism stable self-gravitating objects with a discrete mass and charge spectrum may exist. The incorporation of nonlinearities in the electromagnetic field may effectively reduce their mass spectrum by many orders of magnitude. As a consequence, these objects could be within (or near) the reach of current particle accelerators. We provide an exactly solvable model to support this idea. Source

Civiletti M.,University of Delaware | Pallis C.,University of Valencia | Shafi Q.,University of Delaware
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2014

We explore the upper bound on the tensor-to-scalar ratio r in supersymmetric (F-term) hybrid inflation models with the gauge symmetry breaking scale set equal to the value 2.86 {dot operator} 1016 GeV, as dictated by the unification of the MSSM gauge couplings. We employ a unique renormalizable superpotential and a quasi-canonical Kähler potential, and the scalar spectral index n s is required to lie within the two-sigma interval from the central value found by the Planck satellite. In a sizable region of the parameter space the potential along the inflationary trajectory is a monotonically increasing function of the inflaton, and for this case, r ≲ 2.9 {dot operator} 10 -4, while the spectral index running, |dns/dlnk|, can be as large as 0.01. Ignoring higher order terms which ensure the boundedness of the potential for large values of the inflaton, the upper bound on r is significantly larger, of order 0.01, for subplanckian values of the inflaton, and |dns/dlnk| ≃ 0.006. © 2014 The Authors. Source

Valcarce A.,University of Salamanca | Garcilazo H.,National Polytechnic Institute of Mexico | Vijande J.,University of Valencia
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2014

We present a comparative Faddeev study of heavy baryon spectroscopy with nonrelativistic and relativistic kinematics. We show results for different standard hyperfine interactions with both kinematics in an attempt to learn about the light quark dynamics. We highlight the properties of particular states accessible in nowadays laboratories that would help in discriminating between different dynamical models. The advance in the knowledge of light quark dynamics is a key tool for the understanding of the existence of exotic hadrons. © 2014 The Authors. Source

Pallis C.,University of Valencia
Journal of Cosmology and Astroparticle Physics | Year: 2014

We generalize the embedding of induced-gravity inflation beyond the no-scale Supergravity presented in ref. [1] employing two gauge singlet chiral superfields, a superpotential uniquely determined by applying a continuous R and a discrete n symmetries, and a logarithmic Kähler potential including all the allowed terms up to fourth order in powers of the various fields. We show that, increasing slightly the prefactor (-3) encountered in the adopted Kähler potential, an efficient enhancement of the resulting tensor-to-scalar ratio can be achieved rendering the predictions of the model consistent with the recent BICEP2 results, even with subplanckian excursions of the original inflaton field. The remaining inflationary observables can become compatible with the data by mildly tuning the coefficient involved in the fourth order term of the Kähler potential which mixes the inflaton with the accompanying non-inflaton field. The inflaton mass is predicted to be close to 1014 GeV. Source

Lobo F.S.N.,University of Lisbon | Martinez-Asencio J.,University of Alicante | Olmo G.J.,University of Valencia | Olmo G.J.,Federal University of Paraiba | Rubiera-Garcia D.,Federal University of Paraiba
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2014

We consider the collapse of a charged radiation fluid in a Planck-suppressed quadratic extension of General Relativity (GR) formulated à la Palatini. We obtain exact analytical solutions that extend the charged Vaidya-type solution of GR, which allows to explore in detail new physics at the Planck scale. Starting from Minkowski space, we find that the collapsing fluid generates wormholes supported by the electric field. We discuss the relevance of our findings in relation to the quantum foam structure of space-time and the meaning of curvature divergences in this theory. © 2014. Source

Racker J.,University of Valencia
Journal of Cosmology and Astroparticle Physics | Year: 2014

In models for thermal baryogenesis from particle decays, the mass of the decaying particle is typically many orders of magnitude above the TeV scale. We will discuss different ways to lower the energy scale of baryogenesis and present the corresponding lower bounds on the particle's mass. This is done specifically for the inert doublet model with heavy Majorana neutrinos and then we indicate how to extrapolate the results to other scenarios. We also revisit the question of whether or not dark matter, neutrino masses, and the cosmic baryon asymmetry can be explained simultaneously at low energies in the inert doublet model. © 2014 IOP Publishing Ltd and Sissa Medialab srl. Source

In this paper it is presented a thermodynamic analysis that aims to find the mathematical expression of the variation of extent of reaction with the infinitesimal variation in the temperature at constant volume of a chemical equilibrium mixture. The goal of this paper is to establish an alternative approach to avoid both the Le Chatelier's principle and the problems that emerge when trying to apply its qualitative statements. This attempt is based on the laws of thermodynamics. Source

Pallis C.,University of Valencia
Journal of Cosmology and Astroparticle Physics | Year: 2014

Supersymmetric versions of induced-gravity inflation are formulated within Supergravity (SUGRA) employing two gauge singlet chiral superfields. The proposed superpotential is uniquely determined by applying a continuous R and a discrete n symmetry. We select two types of logarithmic Kähler potentials, one associated with a no-scale-type SU(2,1)/SU(2)× U(1) R×n Kähler manifold and one more generic. In both cases, imposing a lower bound on the parameter cR involved in the coupling between the inflaton and the Ricci scalar curvature - e.g. c ≳ 76, 105, 310 for n=2,3 and 6 respectively - , inflation can be attained even for subplanckian values of the inflaton while the corresponding effective theory respects the perturbative unitarity. In the case of no-scale SUGRA we show that, for every n, the inflationary observables remain unchanged and in agreement with the current data while the inflaton mass is predicted to be 3·1013 GeV. Beyond no-scale SUGRA the inflationary observables depend mildly on n and crucially on the coefficient involved in the fourth order term of the Kähler potential which mixes the inflaton with the accompanying non-inflaton field. Source

Kiuchi K.,Kyoto University | Shibata M.,Kyoto University | Montero P.J.,Max Planck Institute for Astrophysics | Font J.A.,University of Valencia
Physical Review Letters | Year: 2011

Black hole (BH)-torus systems are promising candidates for the central engine of γ-ray bursts (GRBs), and also possible outcomes of the collapse of supermassive stars to supermassive black holes (SMBHs). By three-dimensional general relativistic numerical simulations, we show that an m=1 nonaxisymmetric instability grows for a wide range of self-gravitating tori orbiting BHs. The resulting nonaxisymmetric structure persists for a time scale much longer than the dynamical one, becoming a strong emitter of large amplitude, quasiperiodic gravitational waves. Our results indicate that both, the central engine of GRBs and newly formed SMBHs, can be strong gravitational wave sources observable by forthcoming ground-based and spacecraft detectors. © 2011 American Physical Society. Source

Zapata-Rodriguez C.J.,University of Valencia | Miret J.J.,University of Alicante
Journal of the Optical Society of America B: Optical Physics | Year: 2014

Received September 5, 2013; accepted November 11, 2013; posted November 25, 2013 (Doc. ID 196974); published December 18, 2013 Recent progress is emerging on nondiffracting subwavelength fields propagating in complex plasmonic nanostructures. In this paper, we present a thorough discussion on diffraction-free localized solutions of Maxwell's equations in a periodic structure composed of nanowires. This self-focusing mechanism differs from others previously reported, which lie on regimes with ultraflat spatial dispersion. By means of the Maxwell-Garnett model, we provide a general analytical expression of the electromagnetic fields that can propagate along the direction of the cylinder's axis, keeping its transverse waveform unaltered. Numerical simulations based on the finite element method support our analytical approach. In particular, moderate filling fractions of the metallic composite lead to nonresonant-plasmonic spots of light propagating with a size that remains far below the limit of diffraction. © 2013 Optical Society of America. Source

Background:Although survival for neuroblastoma patients has dramatically improved in recent years, a substantial number of children in the high-risk subgroup still die.Methods:We aimed to define a subgroup of ultra-high-risk patients from within the high-risk cohort. We used advanced morphometric approaches to quantify and characterise blood vessels, reticulin fibre networks, collagen type I bundles, elastic fibres and glycosaminoglycans in 102 high-risk neuroblastomas specimens. The Kaplan–Meier method was used to correlate the analysed elements with survival.Results:The organisation of blood vessels and reticulin fibres in neuroblastic tumours defined an ultra-high-risk patient subgroup with 5-year survival rate <15%. Specifically, tumours with irregularly shaped blood vessels, large sinusoid-like vessels, smaller and tortuous venules and arterioles and with large areas of reticulin fibres forming large, crosslinking, branching and haphazardly arranged networks were linked to the ultra-high-risk phenotype.Conclusions:We demonstrate that quantification of tumour stroma components by morphometric techniques has the potential to improve risk stratification of neuroblastoma patients.British Journal of Cancer advance online publication, 14 July 2016; doi:10.1038/bjc.2016.210 www.bjcancer.com. © 2016 Cancer Research UK Source

INTRODUCTION. Chronic migraine is the most frequent complication of migraine. Its management is complex and difficult, and is based essentially on preventive measures. AIM. To analyse the development of the use of Onabotulinumtoxin A (OnabotA) in migraine, especially in its chronic form, the method of administration, its mechanism of action, its safety profile and its possible indications in clinical practice. DEVELOPMENT. The study conducts a thorough review of all the clinical trials in the literature that have used OnabotA in the prevention of migraine, both in its episodic and its chronic forms, and the outcomes in the chronic form are analysed in detail. CONCLUSIONS. In studies in phase III, OnabotA has proved to be effective in the treatment of patients with chronic migraine, with significant reductions in the mean frequency of days with headaches, the number of headache episodes, the days with migraine or the proportion of patients with severe disability, in addition to other parameters. It is also effective in the subgroup of patients with symptomatic headache due to medication abuse. OnabotA has proved to be safe and well tolerated in this indication, with foreseeable, usually mild or moderate, transitory side effects. In sum, OnabotA is a safe, well-tolerated alternative in the preventive treatment of chronic migraine. Source

Paolucci M.,National Research Council Italy | Grimaldo F.,University of Valencia
Scientometrics | Year: 2014

Peer review works as the hinge of the scientific process, mediating between research and the awareness/acceptance of its results. While it might seem obvious that science would regulate itself scientifically, the consensus on peer review is eroding; a deeper understanding of its workings and potential alternatives is sorely needed. Employing a theoretical approach supported by agent-based simulation, we examined computational models of peer review, performing what we propose to call redesign, that is, the replication of simulations using different mechanisms. Here, we show that we are able to obtain the high sensitivity to rational cheating that is present in literature. In addition, we also show how this result appears to be fragile against small variations in mechanisms. Therefore, we argue that exploration of the parameter space is not enough if we want to support theoretical statements with simulation, and that exploration at the level of mechanisms is needed. These findings also support prudence in the application of simulation results based on single mechanisms, and endorse the use of complex agent platforms that encourage experimentation of diverse mechanisms. © 2014 Akadémiai Kiadó, Budapest, Hungary. Source

Han X.-F.,Yantai University | Wang L.,Yantai University | Wang L.,University of Valencia
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2016

We examine the implication of the 750 GeV diphoton resonance on the two-Higgs-doublet model by imposing various theoretical and experimental constraints. The production rate of the two-Higgs-doublet model is smaller than the cross section observed at the LHC by 2 orders of magnitude. In order to accommodate the 750 GeV diphoton resonance, we extend the two-Higgs-doublet model by introducing additional Higgs fields, and focus on two different extensions: an inert complex Higgs triplet and a real scalar septuplet. As the 125 GeV Higgs is in agreement with the observed data, the production rate for the 750 GeV diphoton resonance can be enhanced to 0.6 fb for the former and 4.5 fb for the latter. The results of the latter are well consistent with the 750 GeV diphoton excess at the LHC. © 2016 American Physical Society. Source

Lorente L.,University of Valencia
International journal of psychology : Journal international de psychologie | Year: 2014

Traditionally, research focussing on psychosocial factors in the construction industry has focused mainly on the negative aspects of health and on results such as occupational accidents. This study, however, focuses on the specific relationships among the different positive psychosocial factors shared by construction workers that could be responsible for occupational well-being and outcomes such as performance. The main objective of this study was to test whether personal resources predict self-rated job performance through job resources and work engagement. Following the predictions of Bandura's Social Cognitive Theory and the motivational process of the Job Demands-Resources Model, we expect that the relationship between personal resources and performance will be fully mediated by job resources and work engagement. The sample consists of 228 construction workers. Structural equation modelling supports the research model. Personal resources (i.e. self-efficacy, mental and emotional competences) play a predicting role in the perception of job resources (i.e. job control and supervisor social support), which in turn leads to work engagement and self-rated performance. This study emphasises the crucial role that personal resources play in determining how people perceive job resources by determining the levels of work engagement and, hence, their self-rated job performance. Theoretical and practical implications are discussed. © 2014 International Union of Psychological Science. Source

Boucenna S.M.,National Institute of Nuclear Physics, Italy | Morisi S.,University of Naples Federico II | Vicente A.,University of Valencia
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2016

Motivated by what is possibly the first sign of new physics seen at the LHC, the diphoton excess at 750 GeV in ATLAS and CMS, we present a model that provides naturally the necessary ingredients to explain the resonance. The simplest phenomenological explanation for the diphoton excess requires a new scalar state, X(750), as well as additional vectorlike (VL) fermions introduced in an ad-hoc way in order to enhance its decays into a pair of photons and/or increase its production cross section. We show that the necessary VL quarks and their couplings can emerge naturally from a complete framework based on the SU(3)L - U(1)X gauge symmetry. © 2016 American Physical Society. Source

Perez-Prieto J.,University of Valencia
Photochemistry and Photobiology | Year: 2013

Photoactive spherical metal and semiconductor nanoparticles (NPs) are smart systems that exhibit unique properties, such as a high surface-to-volume ratio, a broad absorption spectrum and size-dependent properties. They are capped with a considerable number of ligands required to give rise to stable organic and aqueous NP colloidal solutions. In addition, the ligands can also be used to introduce functionality at the NP periphery. In this case, the NP could act as a 3D-scaffold, which would make a high local concentration of a functional moiety at the NP periphery possible, moreover, the photophysical properties of the NP could be tuned. The combined action of the organic capping and the inorganic core can exert an encapsulating effect, i.e. the organic capping could establish specific interactions with nearby molecules and this would enable the molecules to approach or interact with the NP surface. Therefore, the NP core and the ligand can work together providing the overall hybrid system with new properties or capacities. The relevance of the cooperative action between the spherical photoactive core and the capping are shown in this report with several recent examples developed by my research group, some of them in collaboration with other groups. © 2013 The American Society of Photobiology. Source

Ferrer-Blasco T.,University of Valencia | Madrid-Costa D.,European University at Madrid
Clinical and Experimental Optometry | Year: 2011

Background: To evaluate near stereoacuity with the balanced Proclear Multifocal simultaneous vision contact lens.Methods: Twenty-five presbyopic subjects were fitted binocularly with the Proclear Multifocal contact lens and with distance contact lenses combined with reading spectacles, which served as controls. After one month, stereoacuity was measured using the vectographic Titmus and Random dot stereotests and the Howard-Dolman (HD) apparatus under photopic conditions (85 cd/m2) at 40 cm. Binocular high-contrast visual acuities (BHCVA) at distance and near were examined.Results: For the multifocal group, mean stereoacuity with the Howard-Dolman method was 22.40 ± 8.23 seconds of arc. Using the Titmus and the Random dot sterereotests, the values were 56.40 ± 18.00 and 54.80 ± 20.23 seconds of arc, respectively. For the SCL group, mean stereoacuities were 19.9 ± 4.6, 51.2 ± 16.4 and 51.2 ± 20.88 seconds of arc, with the Howard-Dolman, Titmus and the Random dot, respectively. There were no statistically significant differences among groups for Howard-Dolman (p = 0.07), Titmus (p = 0.10) and Random dot (p = 0.17) stereotests. No statistically significant differences were found between the Titmus and the Random dot stereotest values (multifocal group: p = 0.30 and SCL group: p = 0.50), however, these values differ significantly from those found using the Howard-Dolman method for both groups (p < 0.001). For the multifocal group, BHCVA was -0.007 ± 0.060 and 0.012 ± 0.063 logMAR for distance and near vision, respectively. For the SCL group, these values were -0.02 ± 0.05 and -0.01 ± 0.06 logMAR, for distance and near vision, respectively. Comparing both groups there were no statistically significant differences between groups for either distance (p = 0.08) or near (p = 0.09).Conclusions: The Proclear Multifocal contact lens provided good distance and near visual acuity preserving stereopsis. Multifocal optics with one lens biased to distance viewing and the other lens biased toward near viewing minimally affects stereoacuity. © 2010 The Authors. Clinical and Experimental Optometry © 2010 Optometrists Association Australia. Source

Aristizabal Sierra D.,University of Liege | Herrero-Garcia J.,Albanova University Center | Restrepo D.,University of Antioquia | Vicente A.,University of Valencia
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2016

The ATLAS Collaboration (and also CMS) has recently reported an excess over Standard Model expectations for gauge boson pair production in the invariant mass region 1.8-2.2 TeV. In light of these results, we argue that such a signal might be the first manifestation of the production and further decay of a heavy CP-even Higgs resulting from a type-I two Higgs doublet model. We demonstrate that in the presence of colored vectorlike fermions, its gluon fusion production cross section is strongly enhanced, with the enhancement depending on the color representation of the new fer