The University of Ulsan was founded on February 19, 1969 as the Ulsan Institute of Technology. The University was promoted to a full-fledged University on March 1, 1985. The university is located in Mugeo-dong, Ulsan, South Korea. The University currently has approximately 10,500 students enrolled.The city of Ulsan has been recognized as the Korean city which was built around the corporate base of the multinational Hyundai conglomerate. Thus, the Hyundai Conglomerate announced its plan to give 40 billion won to assist a variety of university-industry cooperation projects.This corporate relationship has helped turn the University into one of South Korea's top rated institutions for graduate job placement, as well as increasing its reputation more broadly as one of the top private universities outside of Seoul. Wikipedia.
Yang S.-K.,University of Ulsan
Nature Genetics | Year: 2014
Thiopurine therapy, commonly used in autoimmune conditions, can be complicated by life-threatening leukopenia. This leukopenia is associated with genetic variation in TPMT (encoding thiopurine S-methyltransferase). Despite a lower frequency of TPMT mutations in Asians, the incidence of thiopurine-induced leukopenia is higher in Asians than in individuals of European descent. Here we performed an Immunochip-based 2-stage association study in 978 Korean subjects with Crohn's disease treated with thiopurines. We identified a nonsynonymous SNP in NUDT15 (encoding p.Arg139Cys) that was strongly associated with thiopurine-induced early leukopenia (odds ratio (OR) = 35.6; Pcombined = 4.88 × 10-94). In Koreans, this variant demonstrated sensitivity and specificity of 89.4% and 93.2%, respectively, for thiopurine-induced early leukopenia (in comparison to 12.1% and 97.6% for TPMT variants). Although rare, this SNP was also strongly associated with thiopurine-induced leukopenia in subjects with inflammatory bowel disease of European descent (OR = 9.50; P = 4.64 × 10-4). Thus, NUDT15 is a pharmacogenetic determinant for thiopurine-induced leukopenia in diverse populations. Source
Back S.H.,University of Ulsan |
Kaufman R.J.,Sanford Burnham Institute for Medical Research
Annual Review of Biochemistry | Year: 2012
Given the functional importance of the endoplasmic reticulum (ER), an organelle that performs folding, modification, and trafficking of secretory and membrane proteins to the Golgi compartment, the maintenance of ER homeostasis in insulin-secreting β-cells is very important. When ER homeostasis is disrupted, the ER generates adaptive signaling pathways, called the unfolded protein response (UPR), to maintain homeostasis of this organelle. However, if homeostasis fails to be restored, the ER initiates death signaling pathways. New observations suggest that both chronic hyperglycemia and hyperlipidemia, known as important causative factors of type 2 diabetes (T2D), disrupt ER homeostasis to induce unresolvable UPR activation and β-cell death. This review examines how the UPR pathways, induced by high glucose and free fatty acids (FFAs), interact to disrupt ER function and cause β-cell dysfunction and death. © 2012 by Annual Reviews. All rights reserved. Source
University of Ulsan | Date: 2013-09-23
A stator of a switched reluctance motor includes a stator core part, stator coiling parts, stator salient parts, and pairs of permanent magnets. The stator coiling parts protrude inwardly from the stator core part and have coils wound on an external side thereof. The stator salient parts protrude inwardly from the stator core part and are disposed between the stator coiling parts. Each pair of the permanent magnets is inserted into each of the stator coiling parts and magnetized in the same direction as a direction of a magnetic field generated by the excitation of the coils. This stator has an electromagnetic structure designed to prevent the reversal of a magnetic field generated by the excited coils. The output of the motor is enhanced by inserting the permanent magnets so as to be magnetized in the same direction as a direction of a magnetic field generated by the excited coils.
University of Ulsan and Samsung | Date: 2014-03-26
Disclosed herein are a RF resonator, a RF coil, and a magnetic resonance imaging (MRI) apparatus. The RF resonator includes a dielectric substance which is provided, on one surface thereof, with an electric conductor, and at least one conductor line which is installed on another surface of the dielectric substance so as to face the electric conductor and provided with a plurality of open-cut portions which are disposed in a plurality of rows.
The Asan Foundation and University of Ulsan | Date: 2014-03-27
The present invention relates to a composition for treatment or metastasis suppression of cancers which includes a p34 expression inhibitor or activity inhibitor as an active ingredient. According to the present invention, the p34 protein knock-down causes monoubiquitination of PTEN and accordingly nuclear localization of PTEN is induced, as a result, an Akt pathway which is related to survival, proliferation, invasive properties and metastatic properties of tumors is inhibited, and thus there is an effect of significantly reducing clonogenic potential and tumor forming potential of various cancer cells which simultaneously express PTEN and NEDD4-1. Consequently, the p34 gene expression inhibitor or p34 protein activity inhibitor according to the present invention can be effectively used as a treatment agent or a metastasis suppression agent for cancers.