Udine, Italy
Udine, Italy

The University of Udine is a university in the city of Udine, Italy. It was founded in 1978 as part of the reconstruction plan of Friuli after the earthquake in 1976. Its aim was to provide the Friulian community with an independent centre for advanced training in cultural and scientific studies and it's an important centre for the studies of Friulian language. The University is actively involved in student and staff exchange projects with universities within the European Union, Australia and Canada, and is currently engaged in close collaboration with several universities from Eastern Europe and other non-EU countries. Moreover the University participates in many research projects at national and international level. The present number of students enrolled at the University is approximate 17,000. Wikipedia.


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Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-18-2015 | Award Amount: 6.31M | Year: 2016

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and consequently about 5-20.000 infants per year in Europe. Hypothermic treatment became the only established therapy to improve outcome after perinatal hypoxic-ischemic insults. Despite hypothermia and neonatal intensive care, 45-50% of affected children die or suffer from long-term neurodevelopmental impairment. Additional neuroprotective interventions, beside hypothermia, are warranted to further improve their outcome. Allopurinol is a xanthine oxidase inhibitor and reduces the production of oxygen radicals and brain damage in experimental, animal, and early human studies of ischemia and reperfusion. This project aims to evaluate the efficacy and safety of allopurinol administered immediately after birth to near-term infants with HIE in addition to hypothermic treatment. Beyond this primary objective, the project will provide information on the effect of hypothermia on pharmacokinetics of drugs with a similar metabolism as allopurinol in neonates. Furthermore it will give the opportunity to further develop and validate biomarkers for neonatal brain injury using advanced magnetic resonance imaging, biochemistry, and electroencephalogramms, which will then be available for future studies testing neuroprotective interventions. Finally, this trial will extend our knowledge about incidence of and risk factors for perinatal asphyxia and HIE possibly enabling generation of more preventive strategies for the future.


HarmonicSS vision is to create an International Network and Alliance of partners and cohorts, entrusted with the mission of addressing the unmet needs in primary Sjogren Syndrome; working together to create and maintain a platform with open standards and tools, designed to enable secure storage, governance, analytics, access control and controlled sharing of information at multiple levels along with methods to make results of analyses and outcomes comparable across centers and sustainable through Rheumatology associations. The overall idea of the HarmonicSS project is to bring together the largest well characterized regional, national and international longitudinal cohorts of patients with Primary Sjgrens Syndrome (pSS) including those participating in clinical trials, and after taking into consideration the ethical, legal, privacy and IPR issues for sharing data from different countries, to semantically interlink and harmonize them into an integrative pSS cohort structure on the cloud. Upon this harmonized cohort, services for big data mining, governance and visual analytics will be integrated, to address the identified clinical and health policy pSS unmet needs. In addition, tools for specific diagnostic procedures (e.g. ultrasonography image segmentation), patient selection for clinical trials and training will be also provided. The users of the HarmonicSS platform are researchers (basic/translational), clinicians, health policy makers and pharma companies. pSS is relevant not only due to its clinical impact but also as one of the few model diseases to link autoimmunity, cancer development (lymphoproliferation) and the pathogenetic role of infection. Thus, the study of pSS can facilitate research in many areas of medicine; for this reason, the possibility for sustainability and expandability of the platform is enhanced. Moreover, pSS has a significant impact on the healthcare systems, similar to that of rheumatoid arthritis.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-10a-2014 | Award Amount: 8.10M | Year: 2015

European aquaculture production provides direct employment to 80,000 people and a 3-billion annual turnover. Parasites cause severe disease outbreaks and high economic losses in finfish aquaculture. The overarching goal of ParaFishControl is to increase the sustainability and competitiveness of European Aquaculture by improving understanding of fish-parasite interactions and by developing innovative solutions and tools for the prevention, control and mitigation of the major parasites affecting Atlantic salmon, rainbow trout, common carp, European sea bass, gilthead sea bream and turbot. To achieve these objectives, ParaFishControl brings together a multidisciplinary consortium comprising 30 partners possessing world-leading, complementary, cross-cutting expertise and drawn from public and private research organisations, and the aquaculture industry. The consortium has access to excellent research facilities, diverse biological resources including host-parasite models, and state-of-the-art vaccinology, genomic, proteomic and transcriptomic technologies. The project will: 1) generate new scientific knowledge on key fish parasites, including genomics, life-cycle, invasion strategy and host-parasite interaction data, with special emphasis on host immunity, pathogen virulence and immunomodulation, providing a scientific basis for improved prophylaxis; 2) determine the transfer of parasites between farmed and wild host populations; 3) develop a wide range of novel prophylactic measures, including vaccines and functional feeds; 4) provide a range of advanced or alternative treatments for parasitic diseases; 5) develop cost-effective, specific and sensitive diagnostic tools for key parasitic diseases; 6) assess the risk factors involved in the emergence, transmission and pathogenesis of parasitic diseases; 7) map the zoonotic risks due to fish helminths and; 8) provide a catalogue of good husbandry practices to obtain safe and high-quality fish products.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: SC1-HCO-12-2016 | Award Amount: 1.97M | Year: 2016

Citizens digital health literacy is an essential element for successful eHealth deployment. However, citizens often do not have the necessary skills to find, understand and appraise online health information and apply their knowledge to make health decisions. Digitally health literate citizens are empowered to play a more active role in their health self-management, resulting in improved prevention, adherence to a healthier lifestyle and better health outcomes. IC-Health will provide support for the improvement of digital health literacy in Europe. In particular, the project will design 35 open access online courses (MOOCs), in seven different national languages, for different population cohorts including children, adolescents, pregnant and lactating women, elderly and people affected or susceptible to be affected by type 1 and type 2 diabetes. The identified population cohorts, along with health professionals, academics and other practitioners, will be organised in Communities of Practice and involved directly in the co-creation of the MOOCs content and structure. Once the courses are be designed, they will be tested by the members of the CoPs and by other users. MOOCs use and impact will be monitored and assessed in order to ensure their uptake and sustainability beyond the duration of the project.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.1.3-02 | Award Amount: 7.76M | Year: 2014

Global apiculture is facing an unprecedented crisis of increasing parasite pressure and a loss of hon-eybee biodiversity. SMARTBEES unites a team of experts with the necessary skills to build a bright and sustainable future. The SMARTBEES concept is low risk and high impact, using established protocols and state-of-the-art methods. Including world leading researchers from outwith the traditional honeybee sphere (e.g. acarology, genetic breeding and insect immunology). We will identify crucial facets of honeybee resistance to colony losses, Varroa and viruses. We will provide a step-change in the current mechanistic understanding of these traits, and will characterise the genetic background of the resistance mechanisms in honeybees. We will develop breeding strategies to increase the frequencies of these valuable traits in local honeybee populations, considering the variable need of both common and endangered subspecies and local beekeeping practises. Breeding efforts concentrating on very few races may endanger genetic diversity, to avoid this SMARTBEES will promote multiple local breeding efforts, to conserve local resilient populations and will develop molecular tools for describing and safeguarding future populations. SMARTBEES recognizes responsibility to protect our natural honeybee heritage. SMARTBEES will commission extension science, and work in cooperation with stakeholders to attain conservation by utilisation. SMARTBEES will establish a network of apiaries for performance testing, to encourage local uptake of resistant traits. These will be run mainly by beekeepers, thereby improving the local acceptability and dissemination, and support the long-term sustainability of the apicultural sector. SMARTBEES recognises the need to horizon scan for new threats, and the consortium includes the current EU reference laboratory to that end. SMARTBEES is an opportunity to make a lasting difference to the health, resilience and genetic diversity of our honeybees.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-14a-2014 | Award Amount: 5.35M | Year: 2016

The OLEUM project will generate innovative, more effective and harmonized analytical solutions to detect and fight the most common and emerging frauds and to verify the overall quality of olive oils (OOs). By a core group of 20 partners from 15 countries OLEUM will undertake RESEARCH ACTIVITIES based on the development of IMPROVED and NEW ANALYTICAL METHODS by targeted and omics approaches with the aim: i) to detect new markers of the soft deodorization process; ii) to discover illegal blends between OOs and other vegetable oils; iii) to control OO quality (e.g. freshness); iv) to improve the organoleptic assessment with a Quantitative Panel Test, based on current official methods, and supported by tailored reference materials for better calibration of the sensory panels coupled with rapid screening tools to facilitate the work of the panelists. The most promising OLEUM solutions will be subjected to VALIDATION in conformity with internationally agreed standards by peer laboratories. OLEUM will recreate a realistic deodorization scenario by producing tailored, soft deodorized OOs by lab-scale and up-scaled pilot plants to apply analytical solutions to known samples. Substantial KNOWLEDGE and TECHNOLOGY TRANSFER activities will be envisaged to aid in implementation of: a) a web-based easily-accessible, scalable and constantly updated OLEUM DATABANK, containing all the information from OLEUM research and other reliable international sources, will be available for download data and spectra and to help achieve satisfactory harmonization of analytical approaches among control laboratories; b) the OLEUM NETWORK of relevant OOs stakeholders to maximize the impact of proposed analytical solutions. Finally, a robust dissemination strategy by the OLEUM project aimed at effectively sharing results with all stakeholders in the OO supply chain has the potential to improve consumer and market confidence, and preserve the image of OOs on a global scale.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.71M | Year: 2014

Smart mechatronic structures of the future will have to be extremely energy efficient and self-powering in as many situations as possible. In addition to capabilities such as sensing and reacting to their environment in a predictable and desired manner, the next generation of smart structures will have to exhibit top class energy efficiency. In the context of the proposed ANTARES project (Advanced Training and Research in Energy Efficient Smart Structures) a new holistic approach to the design and implementation of smart structures will include top notch methods for extracting and reusing as much energy available from ambient vibrations as physically possible, developing novel energy efficient transducers for both control and energy harvesting, developing novel self-powered active control systems to reduce vibrations and noise emissions with maximum reductions in structural weight to further reduce the energy consumption. A special care will be taken that the weight reductions do not impair safety and structural integrity through development of appropriate structural health monitoring methods. The proposed ANTARES project aims to bring together early stage researchers and experienced specialists from key players in academia and industry across Europe. The fellows will be trained and supported in their phase of doctoral thesis to work innovative PhD topics as well as to receive specific education in theoretical and practical trainings. ANTARES is formed by 8 participating hosts combining leading education institutes, top research institutions and private sector representatives as well as 4 associated partners, established in European mechatronic and home appliances sector R&D, to assist in the dissemination and outreach or ANTARES results, and in providing dedicated training to enhance the entrepreneurial mind set of the ESRs. The Fellows will profit from top scientific research guidance in combination with highly relevant industrial supervision.


A new class of ligands derived from benzo[h]quinoline are described and these ligands are used to prepare several novel transition metal complexes. The complexes are preferably of the group VIII transition metals iron, ruthenium or osmium, with the benzo[h]quinolone ligands acting as tridentate ligands. The complexes described are proved to be very active catalysts for the reduction of ketones and aldehydes to alcohols, via hydrogen transfer and hydrogenation reactions. These compounds hence can be usefully employed as catalysts in said reduction reactions.


Grant
Agency: European Commission | Branch: H2020 | Program: ERC-ADG | Phase: ERC-ADG-2015 | Award Amount: 1.43M | Year: 2016

This project will explore the idea and gather the evidence to prove it that the so-called printing revolution does not consist in a change in book-making technology but in the process, prolonged over the entire course of the early modern age, of the formation of the printed book market and the creation of readers as purchasers and consumers of books. In order to demonstrate this, the project will reconstruct the economic and legal framework of the European book market by applying an interdisciplinary approach to the economic study of book history. By using unique and hitherto unexplored documentary evidence, this project addresses four fundamental questions relating to the growth of a fully developed book trade and the rise of a society of book consumers within the social and religious context of early modern Europe: the economic issue of book prices; the juridical and political issue of the book privilege system (which in turn influenced the process of book pricing); the management of the bookselling business (focusing on businesses in two major cities in the European book trade, Venice (Bernardino Giunti) and Antwerp (Christopher Plantin)); the technique of building and managing a transnational network for book distribution and sale (analyzing groundbreaking new evidence, an entire year (1522) of correspondence from a Venetian wholesale bookseller, Giovanni Bartolomeo Gabiano). These four research areas will feed into an overarching project which will examine the impact of books and the access of readers to them, together with the development in patterns of cultural consumption which meant that printed books lost the luxury status which they had had throughout the incunabula period to become transformed into popoluxe goods.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-IF-GF | Phase: MSCA-IF-2015-GF | Award Amount: 153.38K | Year: 2016

In many European countries, childbirth still includes a variety of routine medical interventions, such as labour-inducing drugs, the lithotomic position, epidurals, manoeuvres, episiotomy and an excess of surgical deliveries. These also happen for women with low-risk pregnancies, despite WHO recommendations and the findings of evidence-based medicine on the topic. Sometimes women can be coerced into accepting medical interventions, or these interventions are performed without their consent. In Latin America, over the past decade, the term obstetric violence has become part of the legal framework. The concept refers to acts in the context of labour and birth categorised as physically or psychologically violent due to unjustified use of medical interventions. Specific laws against obstetric violence a type of gender-based violence exist in Argentina (2009), Venezuela (2007) and Mexico (2014). In Europe, the issue is discussed by human rights organisations and social movements in order to fight for a more respectful birth, but no country has passed legislation on the matter yet. The project aims to reconstruct and analyse the historical, social and political processes that led to the legal recognition of obstetric violence in Latin America, focusing on the experience in Argentina. The impact that this recognition has had on birth care services and the training of health personnel will be analysed. A qualitative methodology based on case studies and social actors perspectives will be adopted. Medical anthropology with contributions from disciplines such as community health, human rights and gender studies will provide the theoretical framework for the project. Tools and best practices will be identified and transferred at the European level in order to contribute to the public debate on a respectful birth and to support a process of political recognition of obstetric violence in the European context. An Observatory on Obstetric Violence will be implemented.

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