Uberaba, Brazil

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Souza H.M.,University of Uberaba | Ribeiro S.B.F.,Disciplina de Neurologia
Revista Brasileira de Hematologia e Hemoterapia | Year: 2010

Sickle cell disease (SCD) is the commonest genetic illness of human beings. In Brazil it is predominant among black and dark-skinned people; every year 3,500 children are born with SCD and 200,000 with the sickle cell trait. In conditions of hypoxia, red blood cells assume the shape of a sickle. Patients may evolve with capillary occlusion causing acute and chronic tissue lesions in organs, which is almost always accompanied by pain. With the purpose of improving knowledge related to the epidemiologic aspects of the illness and how patients cope with it, 47 over 18-year-old patients from the city of Uberaba were studied during home visits. Of these predominantly female patients (59.6%), 78.7% were black, 17% dark-skinned and 4.3% white. In respect to the type of hemoglobinopathy, 63.8% had hemoglobin SS; 17% had hemoglobin SC and 10.6% had sickle beta-thalassemia. The majority (74.5%) lived in poor regions of the city, 42.5% had concluded high school, 38.2% were either retired or did not have any specific profession, 48.9% earned up to one minimum wage and 19.1% did not receive any wages. In respect to their feelings, 38.3% showed they accepted their illness, 21.3% were resentful, 17% were sad and 46.8% said their lives had changed for the worse in relation to work and 31.9% in relation to leisure. It was possible to show with this study that SCD negatively reflects on activities related to work and on the patient's quality of life. Thus, difficulties in coping with the illness, such as poor housing, unemployment and/or badly paid jobs, may be minimized with social and psychotherapeutic accompaniment, which should be made available to every SCD patient.

Rogerio A.P.,University of Uberaba | Anibal F.F.,Federal University of São Carlos
Mediators of Inflammation | Year: 2012

Leukotrienes (LTs), formed by the 5-lipoxygenase-(5-LO-) catalyzed oxidation of arachidonic acid, are lipid mediators that have potent proinflammatory activities. Pharmacologic or genetic inhibition of 5-LO biosynthesis in animals is associated with increased mortality and impaired clearance of bacteria, fungi, and parasites. LTs play a role in the control of helminth and protozoan infections by modulating the immune system and/or through direct cytotoxicity to parasites; however, LTs may also be associated with pathogenesis, such as in cerebral malaria and schistosomal granuloma. Interestingly, some proteins from the saliva of insect vectors that transmit protozoans and secreted protein from helminth could bind LTs and may consequently modulate the course of infection or pathogenesis. In addition, the decreased production of LTs in immunocompromised individuals might modulate the pathophysiology of helminth and protozoan infections. Herein, in this paper, we showed the immunomodulatory and pathogenic roles of LTs during the helminth and protozoan infections. Copyright 2012 Alexandre P. Rogerio and Fernanda F. Anibal.

Fernandes A.L.T.,University of Uberaba | Fraga Jr. E.F.,University of Sao Paulo | Takay B.Y.,Syngenta
Revista Brasileira de Engenharia Agricola e Ambiental | Year: 2011

The present research aimed to accomplish a comparison between the reference method of estimation of evapotranspiration, Penman-Monteith, considered as the standard method by FAO, with Penman-Piché method, which uses measurements of the evaporation from the Piché's evaporimeter. The period from January 2003 to December 2008 was analyzed consideringdaily data of air temperature, solar radiation, relative humidity of air and wind speed, which were collected with an automatic weather station, located in the Experimental Farm of University of Uberaba, inUberaba, in the State of Minas Gerais, Brazil. Correlation coefficient (r), Willmott agreement index (d) and confidence index (c), which is the product between "r" and "d", were used in the comparison between reference evapotranspiration estimated by Penman-Monteith (ETpm) and Penman-Piche (ETpi). It was concluded that it is possible to estimate the reference evapotranspiration in a satisfactory manner through the evaporation measured by the Piche's evaporimeter. In the months of low relative humidity of air, the evapotranspiration estimated by themethod which considers the measures of Piche's evaporimeter shows reduction in precision, with "r" values of 0,70; 0,78 and 0,70, respectively for the months ofJune, August and September of the studied series.

Geraldo-Martins V.R.,University of Sao Paulo | Geraldo-Martins V.R.,University of Uberaba | Lepri C.P.,University of Sao Paulo | Palma-Dibb R.G.,University of Sao Paulo
Lasers in Medical Science | Year: 2013

The objective of this study was to evaluate the effects of chromium:yttrium-scandium-gallium-garnet (Er,Cr:YSGG) laser irradiation on the acid resistance of dental enamel. Forty human enamel samples were divided into four groups. They were manually irradiated with an Er,Cr:YSGG laser device (λ = 2.78 μm, 20 Hz, 20 s), in a scanning mode, with and without water cooling, according to the following parameters: Group 1: 0.25 W, 62.5 J/cm 2, no water cooling; group 2: 0.25 W, 62.5 J/cm2, 5.0 ml/min; group 3: 0.5 W, 125 J/cm2, no water cooling; group 4: 0.5 W, 125 J/cm2, 5.0 ml/min. No airflow was used. Afterwards, the samples were submitted to an acid challenge and assessed by cross-sectional Knoop microhardness at different depths (20, 40, 60, 80, and 100 μm) from the outer enamel surface. Average values were obtained for both irradiated and control areas in each sample and they were compared to obtain a percentage of microhardness increase. Data were analyzed by analysis of variance and Fisher's exact test (α = 5%). The percentage of microhardness increase observed in group 1 (+23.58%) was similar to group 3 (+19.12%), but higher than groups 2 (+3.61%) and 4 (10.9%) (p < 0.05). The comparison of the depths showed that the Er,Cr:YSGG laser acted in the superficial layers of the dental enamel. The findings of the present study suggest that the energy densities of 62.5 and 125 J/cm2 were capable of increasing the acid resistance of human enamel. The presence of water during irradiation makes it difficult to obtain an enamel surface more resistant to acids. © 2012 Springer-Verlag London Ltd.

De Melo G.L.,Bairro Guanabara | Fernandes A.L.T.,University of Uberaba
Engenharia Agricola | Year: 2012

Evapotranspiration is the process of water loss of vegetated soil due to evaporation and transpiration, and it may be estimated by various empirical methods. This study had the objective to carry out the evaluation of the performance of the following methods: Blaney-Criddle, Jensen-Haise, Linacre, Solar Radiation, Hargreaves-Samani, Makkink, Thornthwaite, Camargo, Priestley-Taylor and Original Penman in the estimation of the potential evapotranspiration when compared to the Penman-Monteith standard method (FAO56) to the climatic conditions of Uberaba, state of Minas Gerais, Brazil. A set of 21 years monthly data (1990 to 2010) was used, working with the climatic elements: temperature, relative humidity, wind speed and insolation. The empirical methods to estimate reference evapotranspiration were compared with the standard method using linear regression, simple statistical analysis, Willmott agreement index (d) and performance index (c). The methods Makkink and Camargo showed the best performance, with "c" values of 0.75 and 0.66, respectively. The Hargreaves-Samani method presented a better linear relation with the standard method, with a correlation coefficient (r) of 0.88.

The present study aims to verify the effectiveness of cross hedging operations for the Uruguayan steer in the futures market for live cattle of the Brazilian Securities, Commodities and Futures Exchange (BM&FBovespa) in relation to risk and return. The tested hypothesis is that a position taken in the futures market of live cattle equal to a position taken in the cash market of Uruguayan steer cancels the price risk. This proposition derives from the classical approach in futures pricing, also known as the expectations hypothesis, which is based in the premise of absence risk premium that comes from market equilibrium theory, and therefore does not allow speculation with the difference between the spot and futures prices for part of the agents that act in the futures market. The hypothesis is tested by applying the full hedge strategy, which determines that the position taken in the futures market is always equal to the spot market. The results show that the futures market for Brazilian live cattle allows for speculation. Profit maximization was ascertained from the returns obtained with the exchange ratio of the uncertainties of prices in the spot market by the variance of the basis, related to cross hedging. The results showed that the average return of the portfolio protected reached approximately 2.60% with a prices risk mitigation of approximately 78%.

de Menezes F.C.,University of Uberaba
Quintessence international (Berlin, Germany : 1985) | Year: 2013

Adhesive restorations have increasingly been used in dentistry, and the adhesive system application technique may determine the success of the restorative procedure. The aim of this study was to evaluate the influence of the application technique of two adhesive systems (Clearfil SE Bond and Adper Scotchbond MultiPurpose) on the bond strength and adhesive layer of composite resin restorations. Eight human third molars were selected and prepared with Class I occlusal cavities. The teeth were restored with composite using various application techniques for both adhesives, according to the following groups (n = 10): group 1 (control), systems were applied and adhesive was immediately light activated for 20 seconds without removing excesses; group 2, excess adhesive was removed with a gentle jet of air for 5 seconds; group 3, excess was removed with a dry microbrushtype device; and group 4, a gentle jet of air was applied after the microbrush and then light activation was performed. After this, the teeth were submitted to microtensile testing. For the two systems tested, no statistical differences were observed between groups 1 and 2. Groups 3 and 4 presented higher bond strength values compared with the other studied groups, allowing the conclusion that excess adhesive removal with a dry microbrush could improve bond strength in composite restorations. Predominance of adhesive fracture and thicker adhesive layer were observed via scanning electron microscopy (SEM) in groups 1 and 2. For groups 3 and 4, a mixed failure pattern and thinner adhesive layer were verified. Clinicians should be aware that excess adhesive may negatively affect bond strength, whereas a thin, uniform adhesive layer appears to be favorable.

Adad S.J.,Federal University of Triângulo Mineiro | Barbosa E Silva G.,Federal University of Triângulo Mineiro | Jammal A.A.,University of Uberaba
Virchows Archiv | Year: 2012

In addition to neurons, interstitial cells of Cajal (ICC) play an important role in coordinating intestinal motility with a pacemaker function. This study aimed to quantitatively analyze ICC, neurons, and muscular area, the latter to correct for quantitation errors resulting from dilation in case of a megacolon and from the dispersion of ICC that can be attributed to muscular hypertrophy. We analyzed 30 colon samples: ten chagasic megacolon (CM), ten chagasic colons without megacolon (CXM), and ten nonchagasic control patients (NC). We measured the area of muscularis propria and counted the number of neurons of the myenteric plexus in a histological section of an intestinal ring and the number of ICC at the level of the myenteric plexus and circular muscle layer, the latter in a section immunohistochemically stained for CD117. Muscular hypertrophy occurred only in the CM group. Compared to the NC group, we found in the CM group a statistically significant reduction of 80 % in the number of neurons, 60% in the number of ICC in the myenteric plexus, and 38 % in the area of circular muscle. In the CXM group, these numbers were highly variable, and their reduction, less pronounced. We conclude that the number of ICC is significantly reduced in CM patients, and that this might contribute to the pathophysiology of CM. However, the development of CM requires severe denervation, whereas CXM generally exhibits less than 50 % denervation, favoring the hypothesis that the reduction in ICC number is, in part, a consequence of denervation. © Springer-Verlag 2012.

Marques V.P.,University of Uberaba
Jornal brasileiro de nefrologia : orgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia | Year: 2010

Acute glomerulonephritis (AGN) after infection of the upper airways or skin is a kidney disease usually caused by streptococcal nephritogenic strains and may present with sudden onset of gross hematuria, hypertension, edema and, occasionally, acute renal failure, is common in childhood and little incident in adults and younger individuals. To analyze, in a descriptive way, data from the initial presentation of GNA after infection of the upper airways or skin in patients over 14 years of age, with emphasis on its epidemiological and clinical aspects. We reviewed the clinical data of 82 patients treated at our department during the period 1972-2001, divided into three groups: group 1, with individuals between 14 and 20 years (n = 52), group 2, between 21 and 30 years (n = 19) and group 3, aged ≥; 31 years (n = 11). There was a predominance of the table among younger patients (group 1), male and white, mostly preceded by infection of the skin, appearing most commonly on lower extremity edema and/or face. In some cases, even with nephrotic syndrome, and hypertension, especially in adults over 30 years (group 3), being the least frequent finding of gross hematuria, and rarely, acute renal failure. Our findings underscore the importance of studying the AGN after infection of the upper airways or skin in younger individuals and adults, seeking to better characterize its clinical, mainly because it is a group of patients where the disease is less incident.

This study aimed to determine the prevalence of elderly patients with an indication of depression by sex and age group and to identify the factors associated with the indication of depression. Analytical, observational and cross studies were conducted with 850 elderly residents in the rural areas of the municipality of Minas Gerais. For data analysis, we applied the prevalence formula and logistic regression model (p<0.05). The project was approved by the Ethics in Research Human of the Triângulo Mineiro Federal University (Protocol No. 1477). The prevalence of the indicators of depression accounted for 22%, with a greater occurrence among females and individuals aged 6070 years. In females, a higher number of comorbidities and higher functional disability with respect to performing the activities of daily living remained associated with the indication of depression. These results reinforce the need to implement actions to promote health and disease prevention, focusing on depression.

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