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Enschede, Netherlands

University of Twente is a university located in Enschede, Netherlands. It offers research and degree programmes in the social and behavioral science and in engineering. In keeping with its entrepreneurial spirit, the University is committed to making economic and social contribution to the region of the Netherlands where it is based. The UT collaborates with Delft University of Technology and Eindhoven University of Technology under the umbrella of the 3TU.Federation, and is also a partner in the European Consortium of Innovative Universities . Wikipedia.


van Gemert-Pijnen J.E.,University of Twente
Journal of medical Internet research | Year: 2011

Many eHealth technologies are not successful in realizing sustainable innovations in health care practices. One of the reasons for this is that the current development of eHealth technology often disregards the interdependencies between technology, human characteristics, and the socioeconomic environment, resulting in technology that has a low impact in health care practices. To overcome the hurdles with eHealth design and implementation, a new, holistic approach to the development of eHealth technologies is needed, one that takes into account the complexity of health care and the rituals and habits of patients and other stakeholders. The aim of this viewpoint paper is to improve the uptake and impact of eHealth technologies by advocating a holistic approach toward their development and eventual integration in the health sector. To identify the potential and limitations of current eHealth frameworks (1999-2009), we carried out a literature search in the following electronic databases: PubMed, ScienceDirect, Web of Knowledge, PiCarta, and Google Scholar. Of the 60 papers that were identified, 44 were selected for full review. We excluded those papers that did not describe hands-on guidelines or quality criteria for the design, implementation, and evaluation of eHealth technologies (28 papers). From the results retrieved, we identified 16 eHealth frameworks that matched the inclusion criteria. The outcomes were used to posit strategies and principles for a holistic approach toward the development of eHealth technologies; these principles underpin our holistic eHealth framework. A total of 16 frameworks qualified for a final analysis, based on their theoretical backgrounds and visions on eHealth, and the strategies and conditions for the research and development of eHealth technologies. Despite their potential, the relationship between the visions on eHealth, proposed strategies, and research methods is obscure, perhaps due to a rather conceptual approach that focuses on the rationale behind the frameworks rather than on practical guidelines. In addition, the Web 2.0 technologies that call for a more stakeholder-driven approach are beyond the scope of current frameworks. To overcome these limitations, we composed a holistic framework based on a participatory development approach, persuasive design techniques, and business modeling. To demonstrate the impact of eHealth technologies more effectively, a fresh way of thinking is required about how technology can be used to innovate health care. It also requires new concepts and instruments to develop and implement technologies in practice. The proposed framework serves as an evidence-based roadmap.


Stoyanova I.I.,University of Twente
Neurobiology of Disease | Year: 2014

Along with the increase in life expectancy over the last century comes the increased risk for development of age-related disorders, including metabolic and neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's diseases. These chronic disorders share two main characteristics: 1) neuronal loss in motor, sensory or cognitive systems, leading to cognitive and motor decline and 2) a strong correlation between metabolic changes and neurodegeneration. In order to treat them, a better understanding of their complexity is required: it is necessary to interpret the neuronal damage in light of the metabolic changes, and to find the disrupted link between the peripheral organs governing energy metabolism and the CNS. This review is an attempt to present ghrelin as part of molecular regulatory interface between energy metabolism, neuroendocrine and neurodegenerative processes. Ghrelin takes part in lipid and glucose metabolism, in higher brain functions such as sleep-wake state, learning and memory consolidation; it influences mitochondrial respiration and shows neuroprotective effect. All these make ghrelin an attractive target for development of biomarkers or therapeutics for prevention or treatment of disorders, in which cell protection and recruitment of new neurons or synapses are needed. © 2014.


Vellekoop I.M.,University of Twente
Optics Express | Year: 2015

Light scattering was thought to be the fundamental limitation for the depth at which optical imaging methods can retain their resolution and sensitivity. However, it was shown that light can be focused inside even the most strongly scattering objects by spatially shaping the wavefront of the incident light. This review summarizes recently developed feedback-based approaches for focusing light inside and through scattering objects. © 2015 Optical Society of America.


Spreeuwers L.,University of Twente
International Journal of Computer Vision | Year: 2011

In this paper we present a new robust approach for 3D face registration to an intrinsic coordinate system of the face. The intrinsic coordinate system is defined by the vertical symmetry plane through the nose, the tip of the nose and the slope of the bridge of the nose. In addition, we propose a 3D face classifier based on the fusion of many dependent region classifiers for overlapping face regions. The region classifiers use PCA-LDA for feature extraction and the likelihood ratio as a matching score. Fusion is realised using straightforward majority voting for the identification scenario. For verification, a voting approach is used as well and the decision is defined by comparing the number of votes to a threshold. Using the proposed registration method combined with a classifier consisting of 60 fused region classifiers we obtain a 99.0% identification rate on the all vs first identification test of the FRGC v2 data. A verification rate of 94.6% at FAR = 0.1% was obtained for the all vs all verification test on the FRGC v2 data using fusion of 120 region classifiers. The first is the highest reported performance and the second is in the top-5 of best performing systems on these tests. In addition, our approach is much faster than other methods, taking only 2.5 seconds per image for registration and less than 0.1 ms per comparison. Because we apply feature extraction using PCA and LDA, the resulting template size is also very small: 6 kB for 60 region classifiers. © 2010 Springer Science+Business Media, LLC.


Hoekstra A.Y.,University of Twente | Wiedmann T.O.,University of New South Wales | Wiedmann T.O.,University of Sydney
Science | Year: 2014

Within the context of Earth's limited natural resources and assimilation capacity, the current environmental footprint of humankind is not sustainable. Assessing land, water, energy, material, and other footprints along supply chains is paramount in understanding the sustainability, efficiency, and equity of resource use from the perspective of producers, consumers, and government. We review current footprints and relate those to maximum sustainable levels, highlighting the need for future work on combining footprints, assessing trade-offs between them, improving computational techniques, estimating maximum sustainable footprint levels, and benchmarking efficiency of resource use. Ultimately, major transformative changes in the global economy are necessary to reduce humanity 's environmental footprint to sustainable levels.

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