Ibaraki, Japan
Ibaraki, Japan

University of Tsukuba , one of the oldest national universities in Japan, is located in the city of Tsukuba, Ibaraki Prefecture in the Kantō region of Japan. The University has 28 college clusters and schools with a total of around 15,000 students . The main Tsukuba campus covers an area of 258 hectares , making it the largest single campus in Japan.It is famous for research in physics, economics, physical education and social science. Its Graduate School of Life and Environmental science is represented on the national Coordinating Committee for Earthquake Prediction. The university is one of the Japanese elite institutions of higher education as part of the Ministry of Education, Culture, Sports, Science and Technology's thirteen "Global 30" selected Project universities. Wikipedia.

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According to the present invention, various biological signals can be measured at an appropriate position without depending on an expert. A biological-signal measurement device includes a sensor 1 that is in contact with a nerve fiber N and detects a nerve action potential generated in the nerve fiber N, a signal processor 2 that is connected to the sensor 1 via wiring 5, the signal processor 2 obtaining a signal based on the nerve action potential from the sensor 1 and wirelessly transmitting the obtained signal, and a receiving/transmitting unit 3 that receives the signal from the signal processor 2. The sensor 1 and the signal processor 2 are embedded in a body. The receiving/transmitting unit 3 receives the signal from the signal processor 2 via skin S.


[Problem] To provide a method for efficiently producing a poly(ethylene glycol)-b-poly(halomethylstyrene), a novel poly(ethylene glycol)-b-poly(halomethylstyrene) produced using the method, and a derivative thereof. [Solution] The target novel copolymer can be provided by introducing a functional group, which enables reversible addition-fragmentation chain transfer (RAFT) polymerization, to the terminal of poly(ethylene glycol) and copolymerizing the resulting poly(ethylene glycol) with a halomethylstyrene.


Patent
University of Tsukuba and Nihon Kohden | Date: 2017-01-25

An electrocardiogram analyzer includes a first acquiring section that acquires a body surface electrocardiogram of a subject, a second acquiring section that acquires an intracardiac electrocardiogram of a ventricle of a heart of the subject, and an analyzing section that performs a frequency analysis on the intracardiac electrocardiogram and includes a range setting section that sets an analysis time range of the frequency analysis in the intracardiac electrocardiogram based on a unit waveform of the body surface electrocardiogram, and a calculating section that, in the analysis time range, performs the frequency analysis on the intracardiac electrocardiogram, and that calculates an index value indicating a ratio of local abnormal ventricular activities in the intracardiac electrocardiogram.


Patent
Kewpie Corporation and University of Tsukuba | Date: 2017-01-11

Hyaluronic acid modified with sphingosine-1-phosphoate, and a medicine comprising the hyaluronic acid as an active ingredient, wherein the medicine can alleviate hepatic disorder caused by hypoxia/reoxygenation by protecting the liver sinusoidal endothelial cells, and the medicine can prevent and/or treat liver failure due to liver transplantation, hepatectomy, or other surgeries associated with liver ischemia/reperfusion.


A biopotential can be measured with high accuracy without the electrodes coming into direct contact with the skin and without being affected by any motion artifact. The present invention comprises a first lead which detects a biopotential containing noise components, a second lead which is electrically isolated from the first lead and detects noise components, and a differential amplifier circuit which is input with a first signal output from the first lead and a second signal output from the second lead, and which amplifies and outputs a difference between the first signal and the second signal, wherein a value of an input impedance on the second signal side of the differential amplifier circuit is set so that the noise components detected from the second lead will have a frequency that is higher than a frequency spectrum of the biopotential.


Patent
Cyberdyne and University of Tsukuba | Date: 2017-04-26

There is provided a motion reproducing system and a motion reproducing apparatus that store human motions and reproduce them. The motion reproducing system includes a data acquiring apparatus acquiring body motion data representing a motion of a subject during the motion, and transmitting the body motion data, a data managing apparatus receiving the body motion data from the data acquiring apparatus, the data managing apparatus including a memory storing the body motion data, and a motion reproducing apparatus receiving the body motion data stored in the memory from the data managing apparatus, and allowing a reproducer to reproduce the motion of the subject using the body motion data, the motion being performed at the time of acquisition of the body motion data.


Provided are a biological-information detecting apparatus and a seat with a backrest capable of detecting biological information about a measurement subject with high accuracy while reducing burdens on the measurement subject in non-contact and non-retraining manner. According to the embodiment, the biological-information detecting apparatus includes first blood-flow measuring means 2 provided at a seat surface of a seat, the first blood-flow measuring means measuring a condition of a blood flow of a popliteal artery of a measurement subject seated in the seat, second blood-flow measuring means 3 provided at a back of the seat, the second blood-flow measuring means measuring a condition of a blood flow of a thoracic aorta of the measurement subject, and blood-pressure calculation means determining a pulse-wave propagation velocity and a degree of arteriosclerosis from blood flow data acquired by the first blood-flow measuring means 2 and blood flow data acquired by the second blood-flow measuring means 3 and calculating blood pressures of the popliteal artery and the thoracic aorta of the measurement subject based on the pulse-wave propagation velocity and the degree of arteriosclerosis.


Patent
Cyberdyne and University of Tsukuba | Date: 2017-04-19

There is provided a wearing-type movement assistance device capable of sufficiently ensuring a degree of freedom of the upper body and coping with a body type difference between wearers. The wearing-type movement assistance device includes a frame to be worn on an upper limb of a wearer, a drive unit provided in each of joints of the frame, a biomedical signal detection unit detecting a biological potential signal of the wearer, a joint angle detection unit detecting an angle of each joint, and a control unit controlling the drive unit based on the biological potential signal and the angle of each joint. The frame includes a vertical frame that extends in a vertical direction, a shoulder frame that is laterally provided in a shoulder width direction from an upper end of the vertical frame, a first arm frame having one end coupled to an end of the shoulder frame via a shoulder joint unit, and a second arm frame having one end coupled to the other end of the first arm frame via an intermediate joint unit and the other end connected to an elbow joint unit. The shoulder joint unit, the intermediate joint unit, and the elbow joint unit are provided with the drive unit.


Patent
Cyberdyne and University of Tsukuba | Date: 2017-04-19

Provided are a prosthesis-mounted action-assist device and a wearable action-assist device that enable step-over-step stair ascending and descending and achieve smooth switching between tasks in accordance with a motion of a wearer. The prosthesis-mounted action-assist device assists an action of a knee disposed between an upper leg frame and a lower leg frame of a prosthetic leg. The device includes an actuator applying power to the prosthetic leg, an absolute angle sensor detecting a hip angle relative to a vertical direction, an angle sensor detecting a knee angle, a floor reaction force sensor detecting a floor reaction force to a wearer, a data storage unit storing reference parameters of phases of tasks, and a control unit comparing the hip angle, the knee angle, and the floor reaction force with the reference parameters stored in the data storage unit to estimate a phase of a task of the wearer and generating an autonomous command signal for causing the actuator to produce power for the phase.


Polarization-sensitive optical image measurement is subject to a non-negligible bias, and consequent deviation in birefringence, in a surrounding range of low SN ratios (signal-to-noise ratios) and low signal strengths; however, this deviation in birefringence is removed to make accurate quantitative measurement possible. Noise-containing OCT signals obtained by polarization OCT are processed using a birefringence calculation algorithm, to obtain measured birefringence, after which noise is statistically adjusted to simulate a measured birefringence distribution and determine the noise characteristics of the measured birefringence values, and then Monte Carlo calculations are repeated by assuming different values for the noise level and the true birefringence value, respectively, to form three-dimensional histogram of combinations of true birefringence values, SN ratios, and measured birefringence values, after which specified measured birefringence values and SN ratios are assumed from the three-dimensional histogram information to obtain a true birefringence probability density distribution, and true birefringence values are estimated from the true birefringence probability density distribution.

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