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Kiyomichi A.,Japan Synchrotron Radiation Research Institute | Adachi T.,High Energy Accelerator Research Organization | Akiyama A.,High Energy Accelerator Research Organization | Murasugi S.,High Energy Accelerator Research Organization | And 16 more authors.
IPAC 2010 - 1st International Particle Accelerator Conference | Year: 2010

The slow extraction beam from the J-PARC Main Ring (MR) to the Hadron Experimental Facility (HD-Hall) is used in various nuclear and particle physics experiments. A flat structure and low ripple noise are required for the spills of the slow extraction. The spill control system has been developed to make a flat structure and small ripple. It consists of the extraction quadrupole magnets and feedback device. The extraction magnets consist of two kinds of quadrupole magnets, EQ (Extraction Q-magnet) which make flat beam and RQ (Ripple Q-magnet) which reject the high frequent ripple noise. The feedback system, which is using Digital Signal Processor (DSP), makes a control pattern for EQ and RQ from spill beam monitor. The extraction magnets and feedback device were installed in September 2009, and spill feedback study has been successfully started from the beam time in October 2009. Here we report the operation status of magnets and first study of beam commissioning with spill feedback system. Source


Iwahashi K.,Azabu University | Fukamauchi F.,Enomoto Clinic | Fukamauchi F.,Tsukuba University of Technology | Aoki J.,Azabu University | And 5 more authors.
Japanese Journal of Neuropsychopharmacology | Year: 2010

During daycare programs of animal assisted therapy (AAT), we collected data on the brain function of two affective disorder patients who received psychotropic drug therapy with fNIRS, after written informed consent was obtained. A male patient at first showed a bloodstream drop, seen in the lower inside part of frontal lobe. In both patients, at least a slight activation of the function of the frontal lobe was seen during the therapy. Therefore, an activation effect of AAT was seen at least objectively by fNIRS. Source


Miyoshi H.,Sports Club NAS Co. | Kinugasa T.,Teikyo Heisei University | Urushihata T.,University of Tsukuba | Urushihata T.,Tsukuba University of Technology | Soma Y.,University of Tsukuba
Japanese Journal of Physical Fitness and Sports Medicine | Year: 2011

This study was carried out in order to compare stride time (gait) variability of walking not only between young and older adults, but also between "fallers" and "non-fallers". Moreover, this study aimed to clarify the relationship between stride time variability, balance ability, muscular strength and fall experience. The subjects were 12 young women aged 21.2±2.2 years (young group) and 27 older women aged 66.6±4.4 years (older group). The older group included 14 fallers and 13 non-fallers. They wore an accelerometer on their back and walked at a slow, preferred or fast pace. The time of heel contact was detected by acceleration waveform, and stride time was estimated. The stride time variability was computed by the coefficient of variance (CV) of stride time. The subjects underwent balance tests and muscular strength tests. The CV of stride time at the preferred and fast pace were significantly larger in the older group than in the young group, even though there was no difference in any of the gait speeds between the two. The CV of stride time was significantly larger in fallers than in non-fallers at the fast pace. Path analysis showed that fall experience was affected by an increase in the CV of stride time and decreased balance ability, but less affected by decreased muscular strength. Therefore, this study suggested that stride time variability when walking fast is useful as an early assessment of fall risk in middle-aged and elderly people and that fall experience was affected by stride time variability and balance ability. Source


Itoh Y.,Tsukuba University of Technology
IEEE Transactions on Consumer Electronics | Year: 2011

This paper introduces an innovative demosaicing algorithm for color filter array (CFA). Conventional demosaicing algorithms usually detect edges in horizontal-, vertical- or omni-direction, and apply a directional filtering along the edge direction. It is found that these algorithms do not properly work for diagonal edges. We, then, invent a similarity based filtering using unified high-frequency (UHF) map. This new technique enables flexible filtering masks so as to be able to deal with edges of any direction. It is confirmed through experiments that the proposed algorithm outperforms state-of-the-art algorithms in terms of PSNR and subjective quality. In addition, the proposed algorithm requires fewer resources than the state-of-the-art algorithms. © 2011 IEEE. Source


Togo T.,Health Science University | Togo T.,Juntendo University | Urata S.,Suzuka University of Medical Science | Sawazaki K.,Hamamatsu University | And 3 more authors.
Evidence-based Complementary and Alternative Medicine | Year: 2011

Complementary and alternative medicine (CAM) therapies have been provided at hospitals along with conventional medicine in industrialized nations. Previous studies conducted in Japan revealed high proportion of Japanese had experience of using CAM, but failed to discuss how it should be provided. The present study aims to clarify the demand for CAM practice at hospitals in Japan. A questionnaire consisting of 41 questions was mailed to 10000 adults randomly selected from the electoral roll of Mie prefecture, Japan in January 2007. The questionnaire asked the subjects about demand for CAM practice at hospitals, types of CAM therapy to be provided and associated reasons. Sociodemographic characteristics, perceived health status, experience and purpose of CAM use, and information resource for CAM were also surveyed. Completed answers were collected from 2824 (28.6) respondents. Two thousand and nineteen (71.5) of the respondents demanded CAM practice at hospitals with the most likely reason of "patients can receive treatment under the guidance of a physicians". The three most popular CAM therapies were Kampo, acupressure/massage/Shiatsu and acupuncture/moxibustion. The demand was positively associated with gender, ages of 40-59 years, annual household incomes of 5-7 million yen, occupation of specialist and technical workers and sales workers and poor health status. Higher demand was observed among those who used both CAM and conventional medical therapies for curative purposes. In conclusion, Japanese show a high demand for CAM practice, hoping to use CAM for curative purposes with monitoring by physicians at hospitals. Copyright 2011 Toshihiro Togo et al. Source


Donoyama N.,Tsukuba University of Technology | Satoh T.,University of Tsukuba | Hamano T.,H Statistics Co Ltd
Trials | Year: 2013

Background: Cancer patients and survivors regularly feel anxious about cancer recurrence or death, even after the conclusion of medical treatment, and they are often highly physiologically and psychologically stressed. Massage therapy is one of the most widely used complementary and alternative therapies used in the hope of alleviating such stress and physical and psychological complaints and to improve health-related quality of life. This randomized phase III, two-armed, parallel group, clinical trial was designed after obtaining positive findings in a preliminary study. The primary objective is to verify the effects of continuous Japanese massage therapy, referred to as Anma therapy, for cancer survivors. The secondary objective is to confirm the immediate effects of a single Anma massage session for cancer survivors.Methods/Design: Sixty cancer survivors older than 20 years of age who have had histologically confirmed uterine cervical, endometrial, ovarian, fallopian tube or peritoneal cancer in the past, but with no recurrence for more than 3 years since receiving standard medical treatment, are being recruited by gynecologists in medical facilities. In the coordinating office, they are randomly allocated to two groups (n = 30 each): an Anma massage group receiving a 40-min Anma massage session once weekly over a 2-month intervention period (total of eight Anma massage sessions) and a control group being followed by medical doctors and receiving no Anma massage sessions. The primary end point is the severity of physical subjective symptoms that cancer survivors report in daily life, assessed using a Visual Analogue Scale. Secondary end points are urine and saliva analyses, psychological condition and health-related quality-of-life scores as determined on the basis of a self-report questionnaire.Discussion: Using the evidence-based findings of this trial, medical professionals should be able to explain the benefits conferred by Anma massage to cancer survivors and provide higher-quality information to better inform patients regarding their decisions about whether to receive such therapy. © 2013 Donoyama et al.; licensee BioMed Central Ltd. Source


Kobayashi Y.,University of Tsukuba | Kobayashi Y.,Tsukuba University of Technology | Tamiya N.,University of Tsukuba | Moriyama Y.,University of Tsukuba | Nishi A.,Yale University
PLoS ONE | Year: 2015

Objective To examine the consequences of early-onset hearing loss on several social and health measures and any related gender differences in Japanese populations. Methods Data from a 2007 nationally representative cross-sectional household survey of 136,849 men and women aged 20 to 39 years were obtained (prevalence of self-reported hearing loss: 0.74%). We focused particularly on four social and health measures: employment status (employed/unemployed), marital status (married/unmarried), smoking behavior (yes/ no), and psychological distress (K6 instrument: ≥ 5 or not). We examined the association of hearing loss for each measure using generalized estimating equations to account for correlated individuals within households. Findings There was no significant association with employment status (p = 0.447). Men with hearing loss were more likely to be married, whereas women with hearing loss were less likely to be married (p < 0.001 for interaction). Although hearing loss was not associated with a current smoking status in men, women with hearing loss were more likely to be current smokers (p < 0.001 for interaction). Moreover, hearing loss was associated with psychological distress in men and women (both p < 0.001). Conclusion These findings suggest that hearing loss is related to social and health issues in daily life, including a lower likelihood of marriage, more frequent smoking, and poorer mental health, especially in women. These issues may reflect a gap between the actual needs of women with hearing loss and the formal support received as a result of existing public health policies in Japan. © 2015 Kobayashi et al. Source


Sakamoto H.,University of Tsukuba | Matsushita S.,Tsukuba University of Technology | Hyodo K.,High Energy Accelerator Research Organization | Tokunaga C.,University of Tsukuba | And 2 more authors.
Acta Radiologica | Year: 2015

Background: Previously, in our laboratory, synchrotron radiation coronary microangiography (SRCA) using Langendorff-perfused rat hearts could visualize a coronary artery of 50 μm in diameter. However, in vivo rat SRCA poses the problem of compromised temporal resolution due to the rapid heart rate of rats. Purpose: To establish a simple method of in vivo rat SRCA with bradycardia induced by intravenous injection of adenosine triphosphate disodium hydrate (ATP). Material and Methods: SRCA was performed at the Photon Factory of the High Energy Accelerator Research Organization (Tsukuba, Japan). Eight male Wistar rats were anesthetized. A catheter for injecting the contrast material was inserted into the carotid artery. Temporary bradycardia was induced by an intravenous bolus injection of 5 mg of ATP, and SRCA was performed immediately thereafter. Results: After ATP administration, the average heart rate decreased from 388 to 73 beats per minute. As a result, we could detect a coronary artery as small as 45 μm in diameter. Conclusion: Our SRCA system which has a high resolution of 9 μm per pixel could detect a coronary artery as small as 45 μm in diameter in the in vivo rat. © The Foundation Acta Radiologica 2014. Source


Sasaki N.,Tsukuba University of Technology
2014 IEEE 3rd Global Conference on Consumer Electronics, GCCE 2014 | Year: 2014

Since 2010, we have been developing a vibration watch application which can run on a visually impaired person's mobile phone. Our watch indicates the time by the number of vibrations. Although our watch worked effectively, its use was limited to Japanese mobile phones which can use Flash contents. In this paper, we propose a new version of the application which can operate on smart phones world-wide. We devised operations which are more suitable for a smart phone in order to check the time and we installed a smart phone version of the application program. Tests of time recognition by smart phone resulted in a high success rate. © 2014 IEEE. Source


Ikeda M.,Juntendo University | Hojo Y.,Juntendo University | Komatsuzaki Y.,Juntendo University | Okamoto M.,Juntendo University | And 3 more authors.
The Journal of endocrinology | Year: 2015

The corticosterone (CORT) level changes along the circadian rhythm. Hippocampus is sensitive to CORT, since glucocorticoid receptors are highly expressed. In rat hippocampus fixed in a living state every 3 h, we found that the dendritic spine density of CA1 pyramidal neurons increased upon waking (within 3 h), as compared with the spine density in the sleep state. Particularly, the large-head spines increased. The observed change in the spine density may be due to the change in the hippocampal CORT level, since the CORT level at awake state (∼30 nM) in cerebrospinal fluid was higher than that at sleep state (∼3 nM), as observed from our earlier study. In adrenalectomized (ADX) rats, such a wake-induced increase of the spine density disappeared. S.c. administration of CORT into ADX rats rescued the decreased spine density. By using isolated hippocampal slices, we found that the application of 30 nM CORT increased the spine density within 1 h and that the spine increase was mediated via PKA, PKC, ERK MAPK, and LIMK signaling pathways. These findings suggest that the moderately rapid increase of the spine density on waking might mainly be caused by the CORT-driven kinase networks. © 2015 Society for Endocrinology. Source


Yamaguchi K.,Nihon University | Suzuki M.,Kyushu University | Kanahori T.,Tsukuba University of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2014

DAISY or accessible EPUB3 could be a good solution to make e-textbooks more accessible. However, unfortunately, a good method to include Braille in them is not established, yet. Due to complicated Situations in Braille notations, automatically converting print contents, especially, ones for math/science into Braille has its own problem. Furthermore, Braille translation in Japanese is usually context-dependent. After reviewing those situations and how Braille is currently treated in DAISY, what are required for Braille capability in DAISY/ accessible EPUB3 are discussed. Based on our DAISY/EPUB3 authoring tools, "ChattyInfty3," and Braille editor, "BrailleInfty," a practical solution to realize the Braille capability is given. © 2014 Springer International Publishing. Source


Jia T.,Tohoku University | Ogawa Y.,Tohoku University | Miura M.,Tsukuba University of Technology | Ito O.,Tohoku University | Kohzuki M.,Tohoku University
PLoS ONE | Year: 2016

Music and exercise can both affect autonomic nervous system activity. However, the effects of the combination of music and exercise on autonomic activity are poorly understood. Additionally, it remains unknown whether music affects post-exercise orthostatic tolerance. The aim of this study was to evaluate the effects of music on autonomic nervous system activity in orthostatic tolerance after exercise. Twenty-six healthy graduate students participated in four sessions in a random order on four separate days: a sedentary session, a music session, a bicycling session, and a bicycling with music session. Participants were asked to listen to their favorite music and to exercise on a cycle ergometer. We evaluated autonomic nervous system activity before and after each session using frequency analysis of heart rate variability. High frequency power, an index of parasympathetic nervous system activity, was significantly increased in the music session. Heart rate was increased, and high frequency power was decreased, in the bicycling session. There was no significant difference in high frequency power before and after the bicycling with music session, although heart rate was significantly increased. Additionally, both music and exercise did not significantly affect heart rate, systolic blood pressure or also heart rate variability indices in the orthostatic test. These data suggest that music increased parasympathetic activity and attenuated the exercise-induced decrease in parasympathetic activity without altering the orthostatic tolerance after exercise. Therefore, music may be an effective approach for improving post-exercise parasympathetic reactivation, resulting in a faster recovery and a reduction in cardiac stress after exercise. © 2016 Jia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Source


Nagano Y.,University of Tsukuba | Nagano Y.,RIKEN | Matsui H.,University of Tsukuba | Shimokawa O.,University of Tsukuba | And 8 more authors.
Journal of Physiology and Pharmacology | Year: 2012

Nonsteroidal anti-inflammatory drugs (NSAIDs) often cause gastrointestinal complications such as gastric ulcers and erosions. Recent studies on the pathogenesis have revealed that NSAIDs induce lipid peroxidation in gastric epithelial cells by generating superoxide anion in mitochondria, independently with cyclooxygenase-inhibition and the subsequent prostaglandin deficiency. Although not clearly elucidated, the impairment of mitochondrial oxidative phosphorylation, or uncoupling, by NSAIDs is associated with the generation of superoxide anion. Physiologically, superoxide is immediately transformed into hydrogen peroxide and diatomic oxygen with manganese superoxide dismutase (MnSOD). Rebamipide is an antiulcer agent that showed protective effects against NSAID-induced lipid peroxidation in gastrointestinal tracts. We hypothesized that rebamipide may attenuate lipid peroxidation by increasing the expression of MnSOD protein in mitochondria and decreasing the leakage of superoxide anion in NSAID-treated gastric and small intestinal epithelial cells. Firstly, to examine rebamipide increases the expression of MnSOD proteins in mitochondria of gastrointestinal epithelial cells, we underwent Western blotting analysis against anti-MnSOD antibody in gastric RGM1 cells and small intestinal IEC6 cells. Secondly, to examine whether the pretreatment of rebamipide decreases NSAID-induced mitochondrial impairment and lipid peroxidation, we treated these cells with NSAIDs with or without rebamipide pretreatment, and examined with specific fluorescent indicators. Finally, to examine whether pretreatment of rebamipide attenuates NSAID-induced superoxide anion leakage from mitochondria, we examined the mitochondria from indomethacin-treated RGM1 cells with electron spin resonance (ESR) spectroscopy using a specific spin-trapping reagent, CYPMPO. Rebamipide increased the expression of MnSOD protein, and attenuated NSAID-induced mitochondrial impairment and lipid peroxidation in RGM1 and IEC6 cells. The pretreatment of rebamipide significantly decreased the signal intensity of superoxide anion from the mitochondria. We conclude that rebamipide attenuates lipid peroxidation by increasing the expression of MnSOD protein and decreasing superoxide anion leakage from mitochondria in both gastric and small intestinal epithelial cells. Source


Homma K.,Japan National Institute of Advanced Industrial Science and Technology | Usuba M.,Tsukuba University of Technology
2011 IEEE/SICE International Symposium on System Integration, SII 2011 | Year: 2011

We have been developing a passive motion exercise system for ankle dorsiflexion/plantarflexion that can be applied to patients with complicated ankle joint deformity. The developed system is expected to reduce edema in lower limbs, and currently we are aiming to find objective indicators for volume of edema by the use of our system. In this paper, the effects of passive motion provided with an ankle dorsiflexion/plantarflexion exercise system on peripheral circulation are examined. The result indicated that skin blood flow and surface skin temperature of the elderly subjects changed associated with passive motion, which suggests that decreased peripheral circulation can be improved with passive motion. © 2011 IEEE. Source


Hiraga R.,Tsukuba University of Technology
Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics | Year: 2011

Emotion recognition in polygons and curved shapes is described. Attneave-style polygons that have no specific meaning by themselves are generated following an algorithm. Attneave-style closed polygons and curved shapes that are transformed with the spline function from the polygons are used to see whether the two types of shapes have differences in emotion recognition. Subjects were found to recognize emotions in curved shapes more than they did in polygons. The kinds of emotions recognized in each type of drawing were different - subjects recognized mostly anger in polygons but joy in curved shapes. They least recognized anger in curved shapes. There were no specific emotion recognition relationships between the pairs of polygons and their transformed curved shapes. © 2011 IEEE. Source


Rai K.,University of Tsukuba | Matsui H.,University of Tsukuba | Kaneko T.,University of Tsukuba | Nagano Y.,University of Tsukuba | And 6 more authors.
Journal of Clinical Biochemistry and Nutrition | Year: 2011

Lansoprazole is effective in healing non-steroidal anti-inflammatory drugs induced ulcers, and antioxidant properties have been thought to play a key role in healing ulcers. We hypothesize that lansoprazole exerts a cytoprotective effect by inhibiting reactive oxygen species leakage from mitochondria and lipid peroxidation. We pretreated gastric epithelial RGM1 cells with lansoprazole and then treated them with indomethacin in vitro. We found that the lansoprazole pretreatment significantly reduced cellular injury, maintained mitochondrial transmembrane potential, and decreased lipid peroxidation. Furthermore, the signal intensity of the electron spin resonance spectrum of the indomethacin-treated mitochondria which were pretreated with lansoprazole showed considerable reduction compared to those without the lansoprazole pretreatment. These results suggest that lansoprazole reduced superoxide production in the mitochondria of indomethacin treated cells, and subsequently inhibited lipid peroxide and cellular injury in gastric epithelial cells. ©2011 JCBN. Source


Tsuchiya M.,University of Tsukuba | Mori M.,University of Tsukuba | Nitta S.-Y.,Tsukuba University of Technology | Nitta S.-Y.,Japan National Astronomical Observatory | And 2 more authors.
Monthly Notices of the Royal Astronomical Society | Year: 2013

We study fundamental properties of steady, spherically symmetric, isothermal galactic outflows in appropriate gravitational potential models. We aim at constructing a universal scale-free theory not only for galactic winds, but also for winds from clusters/groups of galaxies. In particular, we consider effects of mass-density distribution on the formation of transonic galactic outflows under several models of the density distribution profile predicted by cosmological simulations of structure formation based on the cold darkmatter (CDM) scenario. In this study, we have clarified that there exist two types of transonic solutions: outflows from the central region and from a distant region with a finite radius, depending upon the density distribution of the system. The system with a sufficiently steep density gradient at the centre is allowed to have the transonic outflows from the centre. The resultant criterion intriguingly indicates that the density gradient at the centre must be steeper than the prediction of conventional CDM models including Navarro, Frenk and White and Moore et al. This result suggests that an additional steeper density distribution originated by baryonic systems such as the stellar component and/or the central massive black hole is required to realize transonic outflows from the central region. On the other hand, we predict the outflow, which is started at the outskirts of the galactic centre and is slowly accelerated without any drastic energy injection like starburst events. These transonic outflows may contribute secularly to the metal enrichment of the intergalactic medium. © 2013 The Authors Published by Oxford University Press on behalf of the Royal Astronomical Society. Source


Hiraga R.,Tsukuba University of Technology | Hansen K.F.,KTH Royal Institute of Technology
IMMPD 2013 - Proceedings of the 3rd ACM International Workshop on Interactive Multimedia on Mobile and Portable Devices, Co-located with ACM Multimedia 2013 | Year: 2013

We performed an experiment to investigate differences between persons with and without hearing losses when playing a novel audio-based game on a tablet computer, and how persons with hearing losses appreciated the game when they played it with three different types of sound material - speech, music, or mixed speech and music. We analyzed game log files and participants' self-assessments and obtained results showing that there were significant differences between the two participant groups in terms of whether they completed the game. Moreover, the hearing loss group showed a preference for music among the three types of sounds and for the game itself. The two groups listened to music in different ways: hearing participants worked with the music material differently compared with other two types of material, implying that music is the most difficult among the three types. The hearing loss group showed preference for the music only-condition, which is consistent with the results from preliminary experiments we have done. We suggest that this novel game has the potential to improve the listening ability of persons with a hearing loss. © 2013 ACM. Source


Nakamura Y.,Tsukuba University of Technology | Aizawa K.,Tokyo Medical University | Imai T.,University of Tsukuba | Kono I.,University of Tsukuba | Mesaki N.,Teikyo Heisei University
Medicine and Science in Sports and Exercise | Year: 2011

Purpose: To investigate the effect of menstrual cycle states on ovarian and anabolic hormonal responses to acute resistance exercise in young women. Methods: Eight healthy women (eumenorrhea; EM) and eight women with menstrual disorders including oligomenorrhea and amenorrhea (OAM) participated in this study. The EM group performed acute resistance exercises during the early follicular (EF) and midluteal (ML) phases, and the OAM group performed the same exercises. All subjects performed three sets each of lat pull-downs, leg curls, bench presses, leg extensions, and squats at 75%-80% of one-repetition maximum with a 1-min rest between sets. Blood samples were obtained before exercise, immediately after, 30 min after, and 60 min after the exercise. Results: In the EM group, resting serum levels of estradiol and progesterone in the ML phase were higher than those in the EF phase and higher than those in the OAM group. Serum estradiol and progesterone in the ML phase increased after the exercise but did not change in the EF phase or in the OAM group. In contrast, resting levels of testosterone in the OAM group were higher than those in both the ML and EF phases of the EM group. After the exercise, serum growth hormone increased in both the ML and EF phases but did not change in the OAM group. Conclusions: The responses of anabolic hormones to acute resistance exercise are different among the menstrual cycle states in young women. Women with menstrual disturbances with low estradiol and progesterone serum levels have an attenuated anabolic hormone response to acute resistance exercise, suggesting that menstrual disorders accompanying low ovarian hormone levels may affect exercise-induced change in anabolic hormones in women. © 2011 by the American College of Sports Medicine. Source


Yoshitomi T.,University of Tsukuba | Hirayama A.,Tsukuba University of Technology | Nagasaki Y.,University of Tsukuba | Nagasaki Y.,Japan International Center for Materials Nanoarchitectonics
Biomaterials | Year: 2011

The ultimate objective of nanoparticle-based therapy is to functionalize nanomedicines in a micro-disease environment without any side effects. Here, we reveal that our pH-responsive nitroxide radical-containing nanoparticles (RNP pH) disintegrate within the renal acidic lesion and act as scavengers of reactive oxygen species (ROS), leading to a relief of acute kidney injury (AKI). RNP pH was prepared using amphiphilic block copolymers possessing 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) moieties via amine linkage as a side chain of the hydrophobic segment. The self-assembled RNP pH disintegrated at pH below 7.0 because of a protonation of the amino groups in the hydrophobic core of the nanoparticles, thereby resulting in an improvement in ROS scavenging activity. Using a renal ischemia-reperfusion AKI model in mice, the therapeutic effect of RNP pH on ROS damage was evaluated. Unlike the RNP without pH-triggered disintegration (RNP Non-pH), the RNP pH showed extremely high ROS scavenging activity and renal protective effects. It is interesting to note that the side effect of nitroxide radicals was markedly suppressed due to the compartmentalization of nitroxide radicals in the core of RNP pH in untargeted area. The morphology changes in RNP pH were confirmed by analyzing electron spin resonance spectra, and these findings provide the evidence of the real therapeutic effect of the environment-sensitive specific disintegration of nanoparticles in vivo. © 2011 Elsevier Ltd. Source


Xu D.,University of Tsukuba | Murakoshi N.,University of Tsukuba | Igarashi M.,University of Tsukuba | Hirayama A.,Tsukuba University of Technology | And 4 more authors.
Journal of Cardiovascular Electrophysiology | Year: 2012

PPAR-γ Activator as Upstream Therapy for Atrial Fibrillation in Rat. Introduction: The in vivo role of peroxisome proliferator-activated receptor (PPAR)-γ, an essential transcriptional mediator of lipid and glucose metabolism, in atrial fibrillation (AF) remains to be fully elucidated. We investigated the effects of pioglitazone, a PPAR-γ activator, in an in vivo AF rat model. Methods and Results: We studied 3 groups of Wistar rats: young group, 3-month-old rats treated with vehicle; aged group, 9-month-old rats treated with vehicle; and aged+Pio group, 9-month-old rats treated with pioglitazone. After 4-week treatment, AF duration induced by 30-second burst pacing, gene and protein expressions, and atrial structural changes were compared between the 3 groups. Atrial oxidant reducing activity was measured by electron spin resonance method. AF duration was markedly prolonged in the aged group but significantly shortened in the aged+Pio group. Age-induced decrease in free radical reducing activity was reversed by pioglitazone. Gene and protein expression levels of antioxidant molecules Sod2 (MnSOD) and Hspa1a (heat shock 70 protein) were significantly enhanced, and p22 phox and gp91 phox, two NADPH oxidase subunits, were significantly decreased in aged+Pio rats. Pioglitazone treatment significantly increased phosphorylated (p-) Akt but significantly reduced p-ERK1/2 and p-JNK. Pioglitazone significantly restored p-Bad and reduced cleaved caspase-3 and -9, indicating that pioglitazone prevented age-related enhancement of apoptotic signaling. Microscopic analysis revealed suppression of age-related histological changes (interstitial fibrosis and apoptosis) by pioglitazone. Conclusions: Pioglitazone inhibited age-related arrhythmogenic atrial remodeling and AF perpetuation by improving antioxidant capacity and inhibiting the mitochondrial apoptotic signaling pathway. PPAR-γ activators could become a novel upstream therapy for age-related AF. © 2011 Wiley Periodicals, Inc. Source


Jayatilake D.,University of Tsukuba | Ueno T.,University of Tsukuba | Teramoto Y.,University of Tsukuba | Nakai K.,University of Tsukuba | And 5 more authors.
IEEE Journal of Translational Engineering in Health and Medicine | Year: 2015

Dysphagia can cause serious challenges to both physical and mental health. Aspiration due to dysphagia is a major health risk that could cause pneumonia and even death. The videofluoroscopic swallow study (VFSS), which is considered the gold standard for the diagnosis of dysphagia, is not widely available, expensive and causes exposure to radiation. The screening tests used for dysphagia need to be carried out by trained staff, and the evaluations are usually non-quantifiable. This paper investigates the development of the Swallowscope, a smartphone-based device and a feasible real-time swallowing sound-processing algorithm for the automatic screening, quantitative evaluation, and the visualisation of swallowing ability. The device can be used during activities of daily life with minimal intervention, making it potentially more capable of capturing aspirations and risky swallow patterns through the continuous monitoring. It also consists of a cloud-based system for the server-side analyzing and automatic sharing of the swallowing sound. The real-time algorithm we developed for the detection of dry and water swallows is based on a template matching approach. We analyzed the wavelet transformation-based spectral characteristics and the temporal characteristics of simultaneous synchronised VFSS and swallowing sound recordings of 25% barium mixed 3-ml water swallows of 70 subjects and the dry or saliva swallowing sound of 15 healthy subjects to establish the parameters of the template. With this algorithm, we achieved an overall detection accuracy of 79.3% (standard error: 4.2%) for the 92 water swallows; and a precision of 83.7% (range: 66.6%-100%) and a recall of 93.9% (range: 72.7%-100%) for the 71 episodes of dry swallows. © 2015 IEEE. Source


Inaba M.,Tsukuba University of Technology | Chujo T.,University of Tsukuba | Hirano M.,University of Tsukuba
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | Year: 2016

In order to study the initial state of high-energy heavy-ion collisions, a forward calorimeter as an upgrade to the ALICE experiment is in the planning stage. The first beam test of the forward electro-magnetic calorimeter (FoCal-E) prototype was carried out in 2014 at the CERN PS and SPS accelerators. With the aim of reading out a signal from the low-granularity silicon pad sensors of FoCal-E, electronic circuits such as a temperature monitor, a trigger-signal converting-circuit, a trigger-signal processor, an independent regulated power circuit and an isolated high-voltage generator were developed. The electric noise problem was solved by means of both the power circuit and the high-voltage generator, and the signal was successfully read out. © 2015 Elsevier B.V. All rights reserved. Source


Fukushima M.,Showa University | Fukushima M.,Tsukuba University of Technology | Sunagawa M.,Showa University | Katahira H.,Showa University | And 6 more authors.
Journal of the Showa Medical Association | Year: 2015

Press tack needles (PTN) are a kind of acupuncture needle. The aim was to investigate the effects of PTN treatment on social isolation stress and the role of orexin A in this effect. Male rats were divided into three groups: non-stress group (Con), stress plus sham PTN treatment group (Sham) and stress plus PTN treatment group (PTN). The rats in the PTN and Sham groups were housed alone for eight days. In the PTN group, a PTN (Pyonex, Seirin Co., Japan) was fixed on the GV 20 acupuncture point (Baihui) on day 7. We measured the stress behavior based on the time the rats spent biting a wooden stick for ten minutes on days 7 and 8 and then measured the plasma corticosterone levels on day 8. In addition, the plasma orexin A levels and morphology of the lateral hypothalamic orexin neurons were investigated on day 8. On day 8, the biting time and the plasma corticosterone levels were observed to have significantly increased in the Sham group versus the Con group, although these increases were inhibited in the PTN group. Furthermore, the plasma orexin A levels and the number of hypothalamic orexin neurons were significantly increased in the Sham group versus the Con group; these increases were also inhibited in the PTN group. PTN may inhibit the response to social isolation stress. The inhibitory effects of the secretion of hypothalamic orexin may be one of the mechanisms underlying this phenomenon. Source


Sasaki N.,Tsukuba University of Technology | Ishii K.,Ishii Laboratory | Harakawa T.,Maebashi Institute of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2014

We have been developing the Body-Braille system, which transmits Braille characters to disabled people through vibrations on any part of the body. Five years ago, we began working on music applications of this. Using 9 micro vibrators, any melody with a sound range less than 2 octaves can be expressed by vibration. Last year, we developed the music presentation system using only two vibrators. Using special equipment (Pocket-Body braille, Pocket-Bbrll), we performed two experiments and obtained successful results for applying a small number of vibrations to music expression. The details of the system to present music tone by vibration and the results of the experiment are described. © 2014 Springer International Publishing. Source


Li E.,University of Tsukuba | Makita S.,University of Tsukuba | Hong Y.-J.,University of Tsukuba | Kasaragod D.,University of Tsukuba | And 4 more authors.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2016

Optical coherence tomography (OCT) visualizes cross-sectional microstructures of biological tissues. Recent developments of multifunctional OCT (MF-OCT) provides multiple optical contrasts which can reveal currently unknown tissue properties. In this contribution we demonstrate multifunctional OCT specially designed for dermatological investigation. And by utilizing it to measure four different body parts of in vivo human skin, three-dimensional scattering OCT, OCT angiography, polarization uniformity tomography, and local birefringence tomography images were obtained by a single scan. They respectively contrast the structure and morphology, vasculature, melanin content and collagen traits of the tissue. © 2016 SPIE. Source


Nitta S.-Y.,Japan National Astronomical Observatory | Nitta S.-Y.,Tokyo Institute of Technology | Nitta S.-Y.,University of Electro - Communications | Nitta S.-Y.,Tsukuba University of Technology
Astrophysical Journal | Year: 2010

We applied the "self-similar evolutionary model" of magnetic reconnection to simple pre-flare reconnection events driven by flux emergence as the first step in inspecting the realizability of the reconnection events predicted by this model. Previous works paid scant attention to the dependence of the magnetic Reynolds number (R*em) on reconnection events. We aim to clarify how the pre-flare phase of reconnection events in the high R*em range that is frequently encountered in astrophysical applications is observed. We clarify that (1) the time variation of the emission measure distribution strongly depends on R *em, (2) the expected light curve for sufficiently low R*em shows a long lifetime property while that for high R*em shows an impulsive property, and (3) in the case of recurrent small reconnection events on the same loop, the released magnetic energy scale is inversely correlated to the rear-end speed of the moving bright point along the loop. Note that other reconnection models cannot totally explain integration of these properties. If evidence of phenomena with these properties can be detected from, e.g., the Hinode observation, it strongly supports the validity of the self-similar reconnection model. © 2010. The American Astronomical Society. Source


To determine whether any difference exists in the skin-temperature responses of the lower limbs to hot-stone application relative to one-site and three-site abdominal application. Twenty-five female students participated in experimental sessions after a random allocation: 14 participants received a hot-stone application on the umbilicus, superior-umbilicus, and inferior-umbilicus regions (hereafter referred to as the three-site stimulation group); and 11 participants received the hot-stone application on the umbilicus region only (hereafter referred to as the one-site stimulation group). Heated stones were applied for 9 min to participants in both groups. Four arbitrary frames (the lower leg, ankle, proximal foot, and distal foot regions) were created in order to observe and analyze the skin temperature of a lower limb using a thermograph. Observation periods were as follows: before hot-stone stimulation, immediately after stimulation, and 5, 10, 15, and 20 min after stimulation. There was a significant offset interaction of distal foot skin temperature between the groups. The left-side distal foot skin temperature increased at 15 and 20 min following the three-site abdominal hot-stone stimulation. The right-side distal foot skin temperature increased immediately and at 5, 10, 15, and 20 min following the three-site abdominal hot-stone stimulation. No significant change in distal foot skin temperature was observed following the one-site stimulation. Lower-limb skin temperature was altered following hot-stone stimulation applied to the abdomen, and the one-site stimulation and three-site stimulation yielded different distal foot skin-temperature reactions. Source


Nitta S.,Japan National Astronomical Observatory | Nitta S.,Tsukuba University of Technology | Nitta S.,Japan Aerospace Exploration Agency | Nitta S.,Ehime University | And 3 more authors.
Solar Physics | Year: 2012

We find clear evidence for typical chromospheric evaporation associated with small transient brightenings, using the data from the X-ray Telescope (XRT) onboard Hinode. We found 13 events, each having a pair of evaporation upflows arising almost symmetrically from both foot points of a magnetic loop. These facts strongly support the standard flare model based on the magnetic reconnection. The apparent upflow velocities of three of the events are ≈ 500 km s -1, while those of the other events are ≈ 100 km s -1. This is the first clear direct detection of evaporating upflow motion in soft X-ray images from Hinode/XRT; such images were obtained with high cadence (≈ 60 s) and high spatial resolution (1 arcsec). © 2011 Springer Science+Business Media B.V. Source


Hirayama K.,Tokyo Medical University | Ishizu T.,Tsukuba Central Hospital | Shimohata H.,Tokyo Medical University | Miyamoto Y.,Tokyo Medical University | And 8 more authors.
Clinical and Experimental Nephrology | Year: 2010

Background: Bacterial superantigens produced by Staphylococcus aureus may be associated with the onset of proteinase-3 antineutrophil cytoplasmic antibody (PR3-ANCA)-associated vasculitis, including Wegener's granulomatosis. We investigated T-cell subsets to assess the superantigens present in patients with myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis. Methods: Peripheral-blood mononuclear cells (PBMC) obtained from 40 normal controls and ten patients with MPO-ANCA-associated vasculitis were stained with fluorescence-labeled monoclonal antibodies against T-cell markers, including 17 variable regions of T-cell receptor β-chains (TCR-Vβ) and were then analyzed using flow cytometry. Results: Among PBMCs, the percentage of CD3+ cells from patients with MPO-ANCA-associated vasculitis was significantly lower than that from normal controls, but there were no differences between the two groups in the percentage of CD19+ cells or CD16+ cells. Although there were no differences regarding the overall percentage of CD4+ cells between the two groups, the percentage of CD4+CD45RO+ cells in patients with MPO-ANCA-associated vasculitis was significantly higher than that in normal controls, and percentages of CD4+CD45RO+HLA-DR+ and CD4+CD45RO+CD62Llow cells in patients with MPO-ANCA-associated vasculitis were also significantly increased. There was no significant difference between the two groups in terms of the usage of the 17 different TCR-Vβ regions. Conclusion: There was no difference in bacterial superantigens between controls and MPO-ANCA-associated vasculitis patients because of the absence of specific usage of TCR-Vβ regions. Given the elevated levels of memory T cells, conventional antigens rather than superantigens may be associated with the pathogenesis of MPO-ANCA-associated vasculitis. © 2009 Japanese Society of Nephrology. Source


Matsubara M.,University of Tsukuba | Terasawa H.,University of Tsukuba | Hiraga R.,Tsukuba University of Technology
Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics | Year: 2014

This paper describes an experiment on the rhythm perception by hearing-impaired people using three musical contents: Vocal-based songs, vocal-only songs, and instrumental music. The real world consists of many kinds of sounds, not only human speech but also music, songs, and environmental noises. Although typical listening ability exercises these days are primarily optimized for perception of speech rather than other sounds, we assume that musical features can help hearing impaired people to segregate information sounds and the other sounds. Our project is intended to create a musical training that enhances hearing-impaired people's listening ability. In this study, to begin the project, we investigated how the hearing impaired people recognize the rhythmical features in listening to the songs. Nine hearing-impaired undergraduates participated in the tapping experiment. Experimental results showed that musical experience significantly improved their rhythm perception. © 2014 IEEE. Source


Suzuki M.,Kyushu University | Terada Y.,NPO Science Accessibility Net | Kanahori T.,Tsukuba University of Technology | Yamaguchi K.,Nihon University
Studies in Health Technology and Informatics | Year: 2015

New features in our math-OCR software to convert PDF math contents into accessible e-books are shown. A method for recognizing PDF is thoroughly improved. In addition, contents in any selected area including math formulas in a PDF file can be cut and pasted into a document in various accessible formats, which is automatically recognized and converted into texts and accessible math formulas through this process. Combining it with our authoring tool for a technical document, one can easily produce accessible e-books in various formats such as DAISY, accessible EPUB3, DAISY-like HTML5, Microsoft Word with math objects and so on. Those contents are useful for various print-disabled students ranging from the blind to the dyslexic. © 2015 The authors and IOS Press. All rights reserved. Source


Yasduda T.,University of Shiga Prefecture | Hashimoto T.,Kinki University | Tanno I.,Tsukuba University of Technology | Tanaka Y.,Toyo Tire and Rubber Co. | And 3 more authors.
ECCOMAS 2012 - European Congress on Computational Methods in Applied Sciences and Engineering, e-Book Full Papers | Year: 2012

Quasi-equilibrium Lattice Boltzmann model (QELBM) has been developed in order to overcome disruptive non-linear instability occurring in the standard LBGK model and get stable solution at high Reynolds number flow simulation in recent years. In the computation using QELBM, 13 velocity model for 3-dimensional calculation can be used, thereby highly efficient computations of three dimensional flow in high Reynolds number region, which is important for industrial application such as flow around the automobile, are possible. However, the application of QELBM for 3-dimensonal flow has not been done yet, thus the detail about the advantage of QELBM over other methods is not known. In this study, we applied QELBM to lid-driven cubic cavity flow in Reynolds number Re = 100, 400 and 1000, liddriven velosity U = 0.1, and investigated the advantage of QELBM for the stability, accuracy and computational effort by comparing with 13 velocity MRT and 19 velocity LBGK model. Source


Tanno I.,Tsukuba University of Technology | Hashimoto T.,Kinki University | Yasuda T.,University of Shiga Prefecture | Tanaka Y.,Toyo Tire and Rubber Co. | And 3 more authors.
ECCOMAS 2012 - European Congress on Computational Methods in Applied Sciences and Engineering, e-Book Full Papers | Year: 2012

Lattice Boltzmann method (LBM) which is suitable for General Purpose Graphic Processing Unit (GPGPU) and Virtual flux method (VFM) which is one of a Cartesian grid method are implemented on a GPU. Flow around a circular cylinder was simulated by the coupling of LBM and VFM. Lengths of twin vortex behind the cylinder are compared. Present results are agreed with other researchers result. GPU acceleration of LBM and VFM is also examined. Present result evidently shows that a computational time of LBM and VFM on GPU was 17 times faster than that on one core of a CPU. Source


Hiraga R.,Tsukuba University of Technology | Matsubara M.,University of Tsukuba
Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics | Year: 2014

In this paper, we describe an experiment on the cognition of harmony done by three groups: people who have hearing-impairments, people who have little experience of playing music, and people who have a lot experience of playing music. By modifying the accompaniment key, we prepared five types of harmony for a single melody, provided them to the subjects, and asked for their preferred harmony. Their preferences for the accompaniments differed. People with music experience strongly preferred the original accompaniment, while hearing-impaired people cared little about whatever the harmony was. Two hearing groups' preferences did not differ much for the original and other accompaniments, but people with little musical experience had the preferences they lay between those of the other two subject groups. Though many hearing-impaired people are fond of music, this experiment on the cognition of harmony did not find that they appreciate musical harmony. The results of the different preferences of people with a little and a lot of musical experience suggest their preferences may differ between in other aspects of music. © 2014 IEEE. Source


Yamaguchi M.,Meiji University | Nakata T.,Japan National Institute of Advanced Industrial Science and Technology | Watanabe H.,Japan National Institute of Advanced Industrial Science and Technology | Okamoto T.,Tsukuba University of Technology | Kikuchi H.,Meiji University
Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics | Year: 2014

Many people with visual impairments complain about the poor accessibility of conventional CAPTCHA systems because the audio-style test is too difficult for humans. Even a U.S. governmental site, the "We the People" public website, was criticized for the same reason, and thus it implemented a more accessible quiz-based CAPTCHA system. However, this system is vulnerable to simple heuristics. In this study, we demonstrate the insecurity of this type of CAPTCHA system. We demonstrate that our solver program can beat the CAPTCHA with a success rate of over 99%. In addition, we propose a new verbal-style system to replace the quiz-based CAPTCHA. Our system synthesizes several sentences, which have different degrees of naturalness in terms of their contextual meaning, from a set of source documents using a flexible-order Markov chain. Only human users can perceive the difference in the semantics and select the most (or the least) meaningful option correctly. This test is implemented in a verbal style, which means that it is universally suitable for any type of perceptual channel. We implemented our proposed scheme and analyzed its security based on experiments. © 2014 IEEE. Source


Chen N.,Tokyo University of Science | Tanaka K.,Tokyo University of Science | Namatame M.,Tsukuba University of Technology | Watanabe K.,Tokyo University of Science
Proceedings of the 2015-7th International Conference on Knowledge and Smart Technology, KST 2015 | Year: 2015

Chen et al (In prepare) found that deaf people have established similar pattern of color-shape associations with hearing people, such as circle-red, triangle-yellow, and squareblue links. This result indicated that phonological information might have little effect on color-shape associations. However, the strength and consistency of color-shape associations in deaf people is currently unknown. In the present study, we examined the consistency of color-shape associations over a span of time in deaf people. Results showed that deaf people's color-shape associations (e.g., circle-red) were consistent and stable over time. Those results might provide further support for semantic sensory correspondence between colors and shapes. © 2015 IEEE. Source


Kuroki K.,University of Shizuoka | Kodera S.,University of Shizuoka | Kurata N.,Tsukuba University of Technology | Hamamoto T.,Tokyo City University | Saruwatari S.,University of Shizuoka
SenSys 2015 - Proceedings of the 13th ACM Conference on Embedded Networked Sensor Systems | Year: 2015

This paper presents our results of the acquisition of actual data of collapsing buildings, as part of our work on the Battleship Island monitoring project [1]. Our Battleship Island monitoring system performs its task by acquiring data of images, sounds, and acceleration of collapsing buildings. The system is powered by solar energy. To enable the efficient use of solar-powered energy, this paper proposes a datacentric task scheduling system which consists of the DC-LQ (Data Centric LQ-Tracker) and BLB scheduling (batterylevel based scheduling). An evaluation using computer simulation shows that data-centric task scheduling outperforms conventional task scheduling. Source


Noguchi E.,Tsukuba University of Technology
Autonomic Neuroscience: Basic and Clinical | Year: 2010

Digestive disorders impose a heavy medical and economical burden on society and they represent one of the most common reasons for seeking medical consultation. Acupuncture is one of the procedures available to treat these conditions; however, partly because of the limited scientific evidence as yet obtained, the method has not been widely accepted by the medical community as an evidence-based effective treatment.This article presents some recent experimental work on the effectiveness of acupuncture in changing motility in the stomach and duodenum in anesthetized rats. We have shown that electrical or mechanical acupuncture of abdominal points inhibits visceral motility; the effect is due to a spinal reflex that involves activation of sympathetic nerve fibers and requires a peripheral stimulation of skin or muscles capable of activating group VI afferent nerve fibers. In contrast, acupuncture to a hindlimb enhances gastric or duodenal motility, and the reflex at work is supra-spinal and involves the vagus nerve; the peripheral stimulation activates type III afferent fibers.In addition to the reflexes that are activated, the effects of acupuncture may be mediated via centers in the limbic system, the hypothalamus and the brain stem. © 2010 Elsevier B.V. Source


Zhang J.,Tsukuba University of Technology | Takuma J.,Fuji Fire and Marine Insurance Company
Proceedings of 2015 International Conference on Asian Language Processing, IALP 2015 | Year: 2015

Generally, people learn Kanji for The Japan Kanji Aptitude Test (commonly known as Kanken) by using workbooks. However, learners encounter the problems: the financial burden of workbook purchases and the insufficient volume of question collections. In order to solve these problems, we develop a Kanji learning system that can automatically generate question sentences of simulated Kanken tests based on Web search. After a user specifies the test grade and the number of questions, the system generates the specified number of question sentences in which Kanji of the specified grade are included. After the user answers the automatically generated questions, the system scores the answers and presents the learning results to the user. We conduct user studies on comparing three means of Kanji learning and the results show our Kanji learning system can help solve learners' above-mentioned problems. © 2015 IEEE. Source


Hiraga R.,Tsukuba University of Technology | Matsuda N.,University of Tsukuba
Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics | Year: 2010

We are building a musical performance assistance system that uses visual information to supplement the musical communication among deaf and hard-of-hearing people playing music together, enabling them to enjoy music communication playing music representing a certain emotion. We previously collected drawings for which the drawer had an emotion in mind in order to improve the communication in our system, which presents them to the players to enable them to focus on expressing a specific emotion. We thus need to better understand the properties of images that relate to an emotion. After computing the principal components of the image properties, we clustered the drawings into groups representing one of four emotions. We also asked viewers to categorize them on the basis of the emotion they elicited in the viewer. The results showed that the viewers based their judgment on the specific meaning of the drawing rather than the shape, if the shape of drawings was not abstract. The drawings intended to represent fear were well grouped by clustering, while the viewers categorized them as either fear or sadness. The results imply that we can add new drawings with intended emotions to our system as long as their image properties meet our analysis. ©2010 IEEE. Source


Owada S.,Dialysis Unit | Maeba T.,Dialysis Unit | Sugano Y.,Dialysis Unit | Hirayama A.,Tsukuba University of Technology | And 6 more authors.
Nephron - Experimental Nephrology | Year: 2010

Background/Aim: An imbalance in renal redox status contributes to progression of renal dysfunction. We investigated the effects of an oral charcoal adsorbent (AST-120) on renal redox status, superoxide production from renal mitochondria, and serum lipid peroxidation using chronic kidney disease (CKD) model rats. Methods: CKD was induced by 5/6 nephrectomy. CKD rats were divided into 2 groups: controls, and those treated with AST-120 for 20 weeks. We evaluated: (1) renal redox status by in vivo low-frequency electron spin resonance imaging (EPRI); (2) renal superoxide scavenging activity (SSA); (3) superoxide production from renal mitochondria; (4) immunostaining for Cu-Zn superoxide dismutase (SOD), and (5) oxidative stress markers including LDL-negative charge (LDL-CMF), serum lipid peroxide (LPO) and urinary hexanoyl-lysine (HEL). The effect of indoxyl sulfate, a uremic toxin, on mitochondrial superoxide production was also investigated. Results: AST-120 treatment improved renal function, renal SSA, renal mitochondrial superoxide production, renal SOD expression, renal redox status by EPRI, and oxidative stress profiles by LDL-CMF, LPO and urinary HEL. Addition of indoxyl sulfate increased mitochondrial superoxide production and AST-120 also decreased this. Conclusions: Improvements in the redox status and lipid peroxidation induced by AST-120 may delay the progression of CKD. Copyright © 2010 S. Karger AG, Basel. Source


Hashimoto T.,Kinki University | Tanno I.,Tsukuba University of Technology | Yasuda T.,University of Shiga Prefecture | Tanaka Y.,Toyo Tire and Rubber Co. | And 2 more authors.
Computers and Fluids | Year: 2014

Higher order approach of Kinetically Reduced Local Navier-Stokes (KRLNS) equations are applied for two-dimensional (2-D) simulations of Womersley problem and doubly periodic shear layers in order to demonstrate the accuracy, efficiency and the capability to capture the correct transient behavior for unsteady incompressible viscous flows. The numerical results obtained by the KRLNS equations using higher order difference approximations are in excellent agreement with those obtained by the Lattice Boltzmann method (LBM) and the pseudo-spectral method (PSM), which is a standard approach to incompressible viscous flows. It is confirmed that the KRLNS method can capture the correct transient behavior without use of sub-iterations due to a smoothing effect introduced by using the Grand potential in the continuity equation, and keep the fluctuation of velocity divergence at small level by taking sufficiently low Mach number. Parallel computations are carried out on a GPU based on NVIDIA Tesla C1060 system and the provided CUDA library. High values of speedup are obtained for three methods, the KRLNS equations, PSM and LBM. © 2014 Elsevier Ltd. Source


Muto R.,High Energy Accelerator Research Organization | Arakaki Y.,High Energy Accelerator Research Organization | Fan K.,High Energy Accelerator Research Organization | Ishii K.,High Energy Accelerator Research Organization | And 15 more authors.
IEEE Transactions on Applied Superconductivity | Year: 2010

The magnetic septa have been developed for the slow beam extraction from the 50 GeV Proton Synchrotron to the Hadron Experimental Hall at J-PARC (Japan Proton Accelerator Research Complex). The magnetic septa consist of two thin magnetic septa, four medium thick magnetic septa and four thick magnetic septa. The typical operating current is 3000 A and the total kick angle is 77 mrad with the 30 GeV proton beam. All parts of the thin and of the medium thick septum magnets are made of inorganic materials to resist high radiation environment. The positions of the thin and medium thick septa can be aligned remotely in the horizontal range of ± 5 mm, which enables us to minimize the beam loss at the magnetic septum section. © 2006 IEEE. Source


Hiraga R.,Tsukuba University of Technology | Hansen K.F.,KTH Royal Institute of Technology | Kano N.,University of Tsukuba | Matsubara M.,University of Tsukuba | And 3 more authors.
Proceedings - 2015 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2015 | Year: 2015

We previously investigated how hearing-impaired people perceive music in several types of musical experiments. By following-up on the results of some of these experiments with a single test subject Sd, we found that the ability of the subject to perceive music was high and that she appreciated music in a way that was different from that of hearing people. In this paper, we describe three musical experiments with hearing-impaired subjects, their results, and Sd's music perception through the experiments. The three experiments involved the Music Puzzle game, the appreciation of harmony, and tempo perception. Music Puzzle is a music game we made that is played on a tablet and is intended to be used by hearing-impaired persons as a serious game with which they can improve their hearing ability by continuously playing it. The experiment on appreciation of harmony was conducted with three subject groups, and the result showed that experience with music affected the appreciation of music accompanied with the tonal code. Tempo perception was investigated with a simple game in which the subjects tapped along with the tempo of the music. By examining the subjects' hearing acuity in standard medical hearing tests and crossing over the results of these musical experiments, we observed that hearing acuity is not necessarily related to the perception and understanding of music. © 2015 IEEE. Source


Hasegawa S.,Japan Braille Library | Sasaki N.,Tsukuba University of Technology | Harakawa T.,Maebashi Institute of Technology
2010 7th IEEE Consumer Communications and Networking Conference, CCNC 2010 | Year: 2010

There are several barriers to communicate between deaf-blind people and non-disabled people. The communication method of deaf-blind people is totally different from the language of non-disabled people, so they can't communicate with each other directly. Most importantly, deaf-blind people can't understand whether a communication partner is nearby or not. We resolved these issues by developing a system in which deafblind people can communicate bidirectionally using an infrared remote control system. In this system, as a result of the establishment of an infrared communication link, deaf-blind people can detect that communication partners are nearby. ©2010 IEEE. Source


Shiraishi Y.,Kyoto Sangyo University | Zhang J.,Tsukuba University of Technology | Kawai Y.,Kyoto Sangyo University | Akiyama T.,Kyoto Sangyo University
ACM International Conference Proceeding Series | Year: 2012

We present a novel system that combines the advantages of social communication and Web search by simultaneously discovering important pages and users. First, the system provides a communication interface attached to pages, which allows users to talk with each other in real time while browsing the same page, i.e., page-centric communication. Then, the system can efficiently provide two ranking lists of pages and users by analyzing a hybrid structure of hyperlinks (page-page relationship) and social links (page-user relationship and user-user relationship). Thus, users can efficiently search for important pages as well as important users related to their queries through the ranking function, and immediately obtain useful information or knowledge from not only pages themselves but also from other users. © 2012 Authors. Source


Okamoto E.,University of Tsukuba | Ishikawa E.,University of Tsukuba | Yamamoto T.,University of Tsukuba | Matsuda M.,University of Tsukuba | And 8 more authors.
Clinical Neurophysiology | Year: 2015

Objective: Criteria for motor evoked potential (MEP) monitoring include the amplitude criterion and threshold criterion. The aim of our study for the amplitude criterion during removal of brain lesions was to determine a suitable stimulus intensity that can reduce the variability in amplitudes. We also assessed the usefulness of the threshold criterion and amplitude criterion by comparing the variability between the two methods as a preliminary study. Methods: Seventeen patients including 12 cases with no neurological deterioration after surgery were enrolled in this study. The amplitudes in various stimulus intensities and the stimulation threshold (ST) were repeatedly measured during surgery. The stimulus intensities used in the amplitude criterion are described as 'the ST just after dura opening (ST(0))+additional intensity'. The variability was assessed with the coefficient of variation (CV). Results: With direct cortical stimulation (DCS), the CVs of amplitudes were significantly lower at stimulus intensities of more than ST(0)+4mA, with the smallest at ST(0)+10mA. The CV of STs was significantly smaller than that of amplitudes. Conclusions: The variability in the amplitude criterion was significantly reduced using stimulus intensities of more than ST(0)+4mA. The variability in the threshold criterion was significantly smaller than that of the amplitude criterion, even when using a strong stimulus intensity. Significance: The maximal stimulus intensity with no body motion should be used in the amplitude criterion for intraoperative MEP elicited by DCS. © 2014 International Federation of Clinical Neurophysiology. Source


Nagasaki Y.,University of Tsukuba | Yaguchi T.,University of Tsukuba | Matsumura T.,University of Tsukuba | Yoshitomi T.,University of Tsukuba | And 3 more authors.
Biomaterials Science | Year: 2014

The prevention of encapsulating peritoneal sclerosis (EPS) and the enhancement of dialysis efficiency are two important strategies that can improve the quality of life of patients undergoing peritoneal dialysis. We have thus far developed bionanoparticles that effectively scavenge reactive oxygen species (redox nanoparticles; RNPs). The objective of this study was to apply RNPs as a component of dialysate to reduce oxidative stress. Porous silica nanoparticles were combined with RNPs to enhance the effective adsorption capacity of low-molecular weight (LMW) compounds. The silica-containing RNPs (siRNPs) were confirmed to statistically decrease the level of creatinine and blood urea nitrogen in vivo. EPS model rats that underwent an intraperitoneal injection of chlorhexidine gluconate exhibited dysfunction of the peritoneal membrane. siRNP administration did not result in dysfunction of the peritoneal membrane. An LMW nitroxide compound, TEMPOL, also showed a weak peritoneal protective effect, although its efficiency was limited. No blood uptake of siRNPs was observed when they were administered into the peritoneal cavity. However, LMW-TEMPOL diffused into the blood stream, which might have decreased its effective concentration in the peritoneal cavity and led to adverse effects across the entire body. Considering these results, siRNPs are expected to be a new multi-functional nanomaterial for high performance peritoneal dialysis. © The Royal Society of Chemistry. Source


Yoshida K.,Toho University | Yoshida K.,Juntendo University | Yoshida K.,Tsukuba University of Technology
Journal of the Medical Society of Toho University | Year: 2012

Background: The Dong Eui Bo Gam ("Mirror of Eastern Medicine") is the most important book of traditional medicine in Korea. In 2009, it became the first medical book to be included in the UNESCO world's inheritance. After its publication in 1613, the Dong Eui Bo Gam greatly contributed to medical advances in both China and Japan. Research of the publication history of Dong Eui Bo Gam should yield valuable insights into the history of traditional East Asian medicine. The author conducted philological research on the Dong Eui Bo Gam at the library of the Nanjing University of Traditional Chinese Medicine. Methods: I studied the archival records for the Dong Eui Bo Gam in The Nanjing University of Traditional Chinese Medicine Library Bibliography of Traditional Chinese Medicine, which was published in 1992. Results: The library has 9 editions of the Dong Eui Bo Gam (2 Korean editions and 7 Chinese editions); however, the bibliography lists only 8 editions (2 Korean and 6 Chinese editions). Conclusions: Further investigation of collections of the Dong Eui Bo Gam in China will be vital in the historical study of traditional East Asian medicine. Source


Fuji S.,University of Tsukuba | Matsushita S.,Tsukuba University of Technology | Hyodo K.,High Energy Accelerator Research Organization | Osaka M.,University of Tsukuba | And 6 more authors.
General Thoracic and Cardiovascular Surgery | Year: 2016

Objectives: Pulmonary arterial hypertension (PAH) is a progressive disease which causes increased vascular resistance. In this study, our purpose was to quantify the micro-vascular remodeling in monocrotaline-induced PAH rats using synchrotron radiation pulmonary micro-angiography (SRPA), a method we have previously established in an in vivo rat model. To determine the relationship between endothelial function and vascular remodeling, the local expression of endothelin-1 (ET-1), endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VEGF) was evaluated using immunohistochemical staining. Methods: Monocrotaline-induced PAH rats were created by subcutaneous injection of monocrotaline. After 2 weeks, SRPA was performed at the Photon Factory of the High Energy Accelerator Research Organization. The internal diameters of pulmonary arterioles were measured using SRPA images. Semi-quantified analyses of ET-1, eNOS and VEGF expression in pulmonary arterioles were performed by immunohistochemical staining. Results: Micro-vascular density and the internal diameters of pulmonary arterioles were significantly decreased in PAH. ET-1 expression was significantly increased in PAH compared with the control (1.53 ± 0.45 vs. 0.80 ± 0.14) and eNOS expression was significantly decreased in PAH compared with the control (1.12 ± 0.59 vs. 1.91 ± 0.66), although VEGF expression did not differ between the groups. Conclusions: SRPA can be effectively used for visualizing the decreased pulmonary micro-vasculature associated with PAH. Increased ET-1 expression and decreased eNOS expression may contribute to the proliferation and vasospasm of pulmonary arterioles induced by endothelial dysfunction due to PAH. This SRPA technology may help to identify a correlation between endothelial function and micro-vasculature remodeling in PAH. © 2016 The Japanese Association for Thoracic Surgery Source


Kanebako J.,University of Tsukuba | Yamanaka T.,University of Tsukuba | Namatame M.,Tsukuba University of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

We examined the effect of tactile stimuli for rhythm discrimination and hearing impression with ABX methods. We used semantic differential scale composed of 10 impression word pairs. We set the experiment condition with Audio (A), Audio+Vibration (AV), and Vibration (V). In the rhythm discrimination test, the hearing loss group showed better performance in (AV) than (A). The without hearing loss group showed that (AV) differed non-significantly from (A). We focused to “Enjoyable-Not fun” in impression evaluation for the effect of tactile stimuli. As a result of “Enjoyable-Not fun” impression evaluation showed significant differences with hearing loss group and without hearing loss group in (AV) between (A). © Springer International Publishing Switzerland 2016. Source


Kobayashi M.,Tsukuba University of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

To realize a blind bowling support system that tells information to a blind player using a voice synthesizer, a function of ball course detection is being developed after implementation of a function of counting remaining pins. The new function detects a position of thrown ball on an area of arrow marks on the bowling lane using a depth sensor. The sensor is connected to a pipe frame that bridged over the lane. Based on the evaluation by a blind bowling player, it can be shown that the function works basically well, although there is still potential to improve its stability. © Springer International Publishing Switzerland 2016. Source


Namatame M.,Tsukuba University of Technology | Matsuda N.,Carnegie Mellon University
Proceedings 2012 17th IEEE International Conference on Wireless, Mobile and Ubiquitous Technology in Education, WMUTE 2012 | Year: 2012

This paper reports on a classroom practice that focuses on the effectiveness of peer review in drawing picture education for hard-of-hearing students. We developed a peer review application for art in special education (PRAISE). PRAISE consists of a basic evaluation function and a direct comment function that has been implemented in a tablet PC. We followed up on 2 sets of 30 artworks over two years and compared the results of paper review and using our application. We found that the hard-of-hearing students enjoyed collaborative learning using the application. We proposed an improved design of the peer review application for art education that would be useful for hard-of-hearing students. © 2012 IEEE. Source


Kanai Y.,Tokai University | Kanai Y.,Genesia Inc. | Murakami Y.,Tokai University | Murakami Y.,Tsukuba University of Technology | Wakaki M.,Tokai University
Applied Optics | Year: 2010

The photodoping phenomenon of Ag is one of the light-induced phenomena in GeS2 amorphous chalcogenide films. It has potential as a process for fabricating photonic structures, such as waveguides and micro-optics, but its fabrication method is still under research. A dual functional laser scanning system integrating microfabrication and microscope systems was developed. In situ nanoscale fabrication by a UV laser effective for photodoping, and observation by a VIS wavelength laser, which does not affect the material, were demonstrated under same setup in one system. Several fine doped patterns were fabricated and the optical performances were evaluated. These results give the feasibility of forming various photonic structures. © 2010 Optical Society of America. Source


Matsumoto Y.,University of Tsukuba | Noguchi E.,University of Tsukuba | Imoto Y.,University of Tsukuba | Imoto Y.,University of Fukui | And 5 more authors.
Allergology International | Year: 2011

Background: Seasonal allergic rhinitis (SAR) to Japanese cedar (Cryptomeria japonica; JC) is an IgEmediated type I allergy affecting the nasal mucosa. However, the molecular mechanisms that underlie SAR are only partially understood. The aim of the study was to identify novel genes related to SAR during natural exposure to pollens, by using microarray analysis. Methods: Subjects were 32 SAR patients and 25 controls. Total RNA was extracted from CD4+ T cells isolated from peripheral blood mononuclear cells and subjected to microarray analysis with Illumina Human Ref8 BeadChip arrays. The Mann-Whitney test was performed to identify genes whose expression was altered during allergen exposure. Quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) was performed on samples collected from SAR patients and controls to verify the microarray results. Results: Microarray analysis showed that the expression of 3 genes was significantly altered during allergen exposure. Among these 3 genes, the expression of interleukin 17 receptor beta (IL17RB) was confirmed to be upregulated in SAR patients compared to that of the IL17RB gene in healthy, non-allergic controls. The average fold change of IL17RB expression in the real-time RT-PCR experiment was 3.9 (P = 0.003). Conclusions: The present study identified upregulation of IL17RB during natural allergen exposure in patients with SAR, which may further elucidate the molecular mechanisms underlying SAR. © 2011 Japanese Society of Allergology. Source


Miura T.,Tokyo University of Information Sciences | Yabu K.-I.,Tokyo University of Science | Sakajiri M.,Tsukuba University of Technology | Ueda M.,Aviation Environment Research Center | And 4 more authors.
Proceedings of the 15th International ACM SIGACCESS Conference on Computers and Accessibility, ASSETS 2013 | Year: 2013

Accessibility information can allow disabled people to identify suitable pathways to reach their destinations, but it is difficult to obtain new accessible pathway information rapidly because of limited local information disclosure. Thus, it is necessary to develop a comprehensive system that acquires barrier-free information from various sources and makes that information available in an intuitive form. In this study, we aimed to develop a social platform to obtain and present appropriate information depending on the user's situation, such as the user's disabilities and location, and to share the barrier-free information provided by other users. Source


Arai M.,Tokai University | Katai S.,Tsukuba University of Technology | Muramatsu S.-I.,Jichi Medical University | Namiki T.,Chiba University | And 2 more authors.
BMC Complementary and Alternative Medicine | Year: 2012

Background: There have been a few but not precise surveys of the current status of traditional Japanese Kampo education at medical schools in Japan. Our aim was to identify problems and suggest solutions for a standardized Kampo educational model for all medical schools throughout Japan.Methods: We surveyed all 80 medical schools in Japan regarding eight items related to teaching or studying Kampo medicine: (1) the number of class meetings, target school year(s), and type of classes; (2) presence or absence of full-time instructors; (3) curricula contents; (4) textbooks in use; (5) desire for standardized textbooks; (6) faculty development programmes; (7) course contents; and (8) problems to be solved to promote Kampo education. We conducted descriptive analyses without statistics.Results: Eighty questionnaires were collected (100%). (1) There were 0 to 25 Kampo class meetings during the 6 years of medical school. At least one Kampo class was conducted at 98% of the schools, ≥4 at 84%, ≥8 at 44%, and ≥16 at 5%. Distribution of classes was 19% and 57% for third- and fourth-year students, respectively. (2) Only 29% of schools employed full-time Kampo medicine instructors. (3) Medicine was taught on the basis of traditional Japanese Kampo medicine by 81% of the schools, Chinese medicine by 19%, and Western medicine by 20%. (4) Textbooks were used by 24%. (5) Seventy-four percent considered using standardized textbooks. (6) Thirty-three percent provided faculty development programmes. (7) Regarding course contents, " characteristics" was selected by 94%, " basic concepts" by 84%, and evidence-based medicine by 64%. (8) Among the problems to be solved promptly, curriculum standardization was selected by 63%, preparation of simple textbooks by 51%, and fostering instructors responsible for Kampo education by 65%.Conclusions: Japanese medical schools only offer students a short time to study Kampo medicine, and the impetus to include Kampo medicine in their curricula varies among schools. Future Kampo education at medical schools requires solving several problems, including curriculum standardization. © 2012 Arai et al.; licensee BioMed Central Ltd. Source


Ling Y.,Niigata University | Watanabe M.,Niigata University | Watanabe M.,Tsukuba University of Technology | Yoshii H.,Tohoku University | Akazawa K.,Niigata University
BMC Public Health | Year: 2014

Background: The stigma of schizophrenia constitutes a major barrier to early detection and treatment of this illness. Anti-stigma education has been welcomed to reduce stigma among the general public. This study examined the factors associated with the effectiveness of a web-based educational program designed to reduce the stigma associated with schizophrenia. Methods. Using Link's Devaluation-Discrimination Scale to measure stigma, the effect of the program was measured by the difference in pre- and post-program tests. In the present study, we focused on program participants whose stigma towards schizophrenia had considerably improved (a reduction of three points or more between pre- and post-program tests) or considerably worsened (an increase of three points or more). The study participants were 1,058 parents of middle or high school students across Japan, including 508 whose stigma had significantly decreased after the program and 550 whose stigma had significantly increased. We used multiple logistic regression analysis to predict a considerable reduction in stigma (by three or more points) using independent variables measured before exposure to the program. In these models, we assessed the effects of demographic characteristics of the participants and four measures of knowledge and views on schizophrenia (basic knowledge, Link's Devaluation-Discrimination Scale, ability to distinguish schizophrenia from other conditions, and social distance). Results: Participants' employment status, occupation, basic knowledge of schizophrenia, pre-program Link's Devaluation-Discrimination Scale score, and social distance were significant factors associated with a considerable decrease in the stigma attached to schizophrenia following the educational program. Specifically, full-time and part-time employees were more likely to experience reduced stigma than parents who were self-employed, unemployed, or had other employment status. Considerable decreases in stigma were more likely among parents working in transportation and communication or as homemakers than among other occupational groups. In addition, parents with higher pre-program levels of stigma, lower basic knowledge, or lower social distance were more likely to have reduced levels of stigma. Conclusions: Based on the regression analysis results presented here, several possible methods of reducing stigma were suggested, including increasing personal contact with people with schizophrenia and the improvement of law and insurance systems in primary and secondary industries. © 2014 Ling et al.; licensee BioMed Central Ltd. Source


Yamamoto N.,University of Tsukuba | Shiroma S.,Ehime University | Nishioka T.,Tsukuba University of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2011

Various kinds of method that decrease the language effects have been tried for understanding the spatial cognition of hard of hearing students. An experimental method and its application are proposed that uses a programming language in this article. The communication using a simple language and graphical interface is expected to give us a useful way for students' understanding the question and expressing their ideas. The navigation problems in the experiments were built using the programming language. Operational indications of the subjects were described and collected using it as well. Comparable records of both hard of hearing and hearing students' reactions were obtained and analyzed. © 2011 Springer-Verlag. Source


Inaba M.,Tsukuba University of Technology | Tanno K.,University of Miyazaki | Tamura H.,University of Miyazaki | Ishizuka O.,Daiichi Institute of Technology
IEICE Transactions on Information and Systems | Year: 2010

In this paper, optimization and verification of the currentmode multiple-valued digit ORNS arithmetic circuits are presented. The multiple-valued digit ORNS is the redundant number system using digit values in the multiple-valued logic and it realizes the full-parallel calculation without any ripple carry propagation. First, the 4-bit addition and multiplication algorithms employing the multiple-valued digit ORNS are optimized through logic-level analyses. In the multiplier, the maximum digit value and the number of modulo operations in series are successfully reduced from 49 to 29 and from 3 to 2, respectively, by the arrangement of addition lines. Next, circuit components such as a current mirror are verified using HSPICE. The proposed switched current mirror which has functions of a current mirror and an analog switch is effective to reduce the minimum operation voltage by about 0.13 volt. Besides an ordinary strong-inversion region, the circuit components operated under the weak-inversion region show good simulation results with the unit current of 10 nanoamperes, and it brings both of the lower power dissipation and the stable operation under the lower supply voltage. Copyright © 2010 The Institute of Electronics, Information and Communication Engineers. Source


Nakazawa Y.,Niigata University | Makino H.,Niigata University | Nishimori K.,Niigata University | Wakatsuki D.,Tsukuba University of Technology | Komagata H.,Saitama Medical School
IPIN 2014 - 2014 International Conference on Indoor Positioning and Indoor Navigation | Year: 2014

We are focusing our research on indoor positioning technology; specifically, a type that uses Visible Light Communication (VLC); modulatable LED lights transmit data at 9600 bps, using 4 Pulse Position Modulation (4PPM), while a fish-eye lens-equipped camera receives the light signal over a 160-degree field-of-view. This type of lighting requires neither additional space nor-power. We assigned a unique ID to each LED, in order to recognize its position. Self-location is calculated from the relationship between the LED positions and coordinates on the image plane. In our previous research, we confirmed that self-location can be determined within 10 cm, using our system. However, we needed to attach dedicated transmitters to each LED used for positioning, especially in large buildings such as hospitals and shopping malls. So, in this paper, we propose LED-tracking and ID-estimation using LEDs with known IDs; doing so will significantly reduce the cost of installing- and running transmitters. Additionally, with the increased use of LEDs for positioning, accuracy naturally improves. We conducted experiments with the camera moving in 2 different environments: a) a small area, with just 4 LEDs; b) the VLC platform with a total of 24 LEDs, to demonstrate that as many as 13 LEDs can be identified. With 2 or more IDs detected beforehand, unidentified LEDs, as well as some that failed to be tracked, could be estimated, while the camera was in motion. Average positioning error in the smaller environment and the VLC platform were 3.78 cm and 6.96 cm, respectively. From this, location can be determined, even when some LEDs are offline. © 2014 IEEE. Source


Fukuyama H.,Japan Building Research Institute | Fujisawa M.,Tsukuba University of Technology | Abe A.,Tokyo Soil Research Co. | Kabeyasawa T.,Japan National Institute for Land and Infrastructure Management | And 2 more authors.
Journal of Disaster Research | Year: 2013

Unique foundations consisting of stones wrapped in vegetable fiber bags called shicra ("woven") have been found in many Pacific coast ruins constructed about 5,000 years ago as shrines in Peru. A shaking table test was conducted to investigate earthquake response properties of these shicra foundations. Results showed that in base isolation performance, shicra foundations "rolled" during earthquake vibration the same as in the case of roller base isolation systems. Source


Yamaguchi K.,Nihon University | Kanahori T.,Tsukuba University of Technology | Suzuki M.,Kyushu University
Assistive Technology Research Series | Year: 2013

A new system to produce DAISY textbooks for math and science from PDF is shown. In it, correct aloud-reading and speech control can be assigned to technical contents including math expressions. What are required in accessible math/science e-textbooks concerning speech and Braille output capabilities are also discussed. By making use of our system, we work on a collaborative project with the Japan Braille Library to produce accessible e-textbooks and to provide them to various print-disabled students. © 2013 The authors and IOS Press. All rights reserved. Source


Matsui H.,University of Tsukuba | Nagano Y.,University of Tsukuba | Shimokawa O.,University of Tsukuba | Kaneko T.,University of Tsukuba | And 7 more authors.
Journal of Gastroenterology | Year: 2011

Background: Gastric hydrochloric acid (HCl) has been regarded as an inciting factor in gastric mucosal injuries and has been reported to induce lipid peroxidation in vitro. However, because HCl is not an oxidant per se, the exact mechanism by which the acid induces lipid peroxidation is unknown. We hypothesized that gastric acid may disrupt mitochondrial transmembrane potential and induce the production of superoxide in mitochondria, which subsequently may induce lipid peroxidation and apoptosis in gastric mucosal cells. Methods: Firstly we treated gastric epithelial RGM1 cells with solutions containing various concentrations of HCl (i.e., of varying pH), and examined cellular injury, lipid peroxidation, and apoptosis with specific fluorescent dyes. Secondly, we performed electron paramagnetic resonance (EPR) spectroscopy of isolated, acid-exposed mitochondria from the cells, using a spin-trapping reagent for superoxide, 5-(2,2-dimethyl-1,3-propoxy cyclophosphoryl)-5-methyl-1-pyrroline N-oxide (CYPMPO). Finally, we established novel RGM1 cells that overexpressed manganese superoxide dismutase (MnSOD), which removes superoxide from mitochondria, and examined the effect of acid treatment on cellular membrane lipid peroxidation. Results: The results indicated that the exposure to acid indeed induced cellular injury, cellular lipid peroxidation, apoptosis, and the demonstration of the exact superoxide spectra on EPR spectroscopy in gastric epithelial cells, and that overexpression of MnSOD decreased superoxide production and prevented cellular lipid peroxidation. Conclusion: These results suggested that gastric acid, like nonsteroidal anti-inflammatory drugs (NSAIDs), induces mitochondrial superoxide production, which induces gastric cellular injury by triggering cellular lipid peroxidation and apoptosis. © 2011 Springer. Source


Yamaguchi M.,Meiji University | Okamoto T.,Tsukuba University of Technology | Hiroaki K.,Meiji University
Proceedings - 2015 18th International Conference on Network-Based Information Systems, NBiS 2015 | Year: 2015

The "Completely Automated Public Turing test to tell Computers and Humans Apart" (CAPTCHA) is a technique that prevents unauthorized access by bots. Most studies of CAPTCHA systems use human cognitive capacities as a countermeasure to facilitate recognition techniques. Differentiating between natural and awkward objects is an approach used to distinguish humans from bots. However, this approach is vulnerable to adversaries who exploit the differences in relative frequency between natural and awkward objects because of the difficulty in collecting natural objects. In this study, we propose a new scheme that does not require the utilization of natural objects, thereby addressing this shortcoming. Our proposed method requires that humans always distinguish awkward objects, which are generated by different parameters. We evaluated our scheme in several experiments. © 2015 IEEE. Source


Tanno I.,Tsukuba University of Technology | Hashimoto T.,Kinki University | Yasuda T.,University of Shiga Prefecture | Tanaka Y.,Toyo Tire and Rubber Co. | And 3 more authors.
Computers and Fluids | Year: 2013

The authors implemented artificial compressibility method (ACM) with virtual flux method (VFM) on a GPU to simulate incompressible unsteady state flow fields around a cylinder, and lattice Boltzmann method (LBM) on a GPU to simulate incompressible turbulent flows. In this study, unsteady flow fields around a circular cylinder were calculated by LBM with VFM. The history of the length of twin vortex behind a circular cylinder and the Strouhal number were compared with that of the other researchers; also, the speedup obtained by a GPU is shown. © 2013 Elsevier Ltd. Source


Hashimoto T.,Kinki University | Tanno I.,Tsukuba University of Technology | Tanaka Y.,Toyo Tire and Rubber Co. | Morinishi K.,Kyoto Institute of Technology | Satofuka N.,University of Shiga Prefecture
Computers and Fluids | Year: 2013

Kinetically Reduced Local Navier-Stokes (KRLNS) equations are applied for two-dimensional (2-D) simulation of doubly periodic shear layers in order to demonstrate the accuracy, efficiency and the capability to capture the correct transient behavior. The numerical results obtained by the KRLNS equations are compared with those obtained by the artificial compressibility method (ACM) and the lattice Boltzmann method (LBM). The velocity divergence as a function of time in the KRLNS method is compared with that of the ACM. Parallel computations are carried out on a GPU by using the CUDA library provided by the NVIDIA. © 2013 Elsevier Ltd. Source


Jayatilake D.,University of Tsukuba | Suzuki K.,University of Tsukuba | Teramoto Y.,University of Tsukuba | Ueno T.,University of Tsukuba | And 5 more authors.
2014 IEEE-EMBS International Conference on Biomedical and Health Informatics, BHI 2014 | Year: 2014

Dysphagia can cause serious challenges to both physical and mental health. Aspiration due to dysphagia is a major health risk that could cause pneumonia, and even death. As a result, monitoring and managing dysphagia is of utmost importance. This study investigates the development of a smartphone-based device and a feasible real-time swallowing sound processing algorithm for the automatic screening for swallowing ability. The videofluoroscopic swallow study (VFSS), which is considered the gold standard for the diagnosis of dysphagia, is not widely available, expensive and causes exposure to radiation. The screening tests used for dysphagia need to be carried out by trained staff and the evaluations are often non-quantifiable. The Swallowscope we developed is a wearable device based on mobile health, and uses the swallowing sound to quantitatively evaluate swallowing ability. As swallowing sound can be captured continuously and during activities of daily life with minimal intervention, it is an ideal approach to monitor swallowing activities, and its continuous monitoring has a better probability of capturing aspirations and risky swallow patterns. This paper describes the real-time smartphone based algorithm and the application we developed to monitor swallowing activities and evaluates the recognition accuracy by comparing them with VFSS evidence. © 2014 IEEE. Source


Tomonaga S.,Kyoto Sangyo University | Nakajima S.,Kyoto Sangyo University | Inagaki Y.,Kizasi Company | Nakamoto R.,Kizasi Company | And 2 more authors.
Lecture Notes in Engineering and Computer Science | Year: 2014

The goal of our research is to discover factors which predict which words will become buzzwords-terms representing topics that have become popular-within the blogosphere. In this paper, we propose a method which evaluates bloggers' buzzword prediction ability by analyzing how early bloggers mentioned past buzzwords. We do so by measuring how early a buzzword is first mentioned until the buzzword's peak in popularity. We describe this method and also report the evaluation on buzzword classification. Source


Suzuki H.,University of Tsukuba | Kaneko T.,University of Tsukuba | Mizokami Y.,University of Tsukuba | Narasaka T.,University of Tsukuba | And 5 more authors.
World Journal of Gastroenterology | Year: 2013

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that may become intractable when treated with conventional medications such as aminosalicylates, corticosteroids, and azathioprine. The herbal medicine Qing Dai has traditionally been used in Chinese medicine to treat UC patients, but there is a lack of published data on the efficacy of Qing Dai in UC treatment. We report several cases of patients with intractable UC who take Qing Dai in a retrospective observational study. Furthermore, we explore the mechanisms of action of Qing Dai. Nine patients with active UC who received conventional medications but wished to receive Qing Dai as an alternative medication were included in our analysis. The UC severity level was determined based on the clinical activity index (CAI). Additionally, 5 of the 9 patients were endoscopically evaluated according to the Matts grading system. Each patient received 2 g/d of Qing Dai orally and continued taking other medications for UC as prescribed. Electron spin resonance was applied to explore the mechanisms of action of Qing Dai. After 4 mo of treatment with Qing Dai, the CAI score decreased from 8.3 ± 2.4 to 2.4 ± 3.4 (mean ± SD; P < 0.001). Similarly, the endoscopic Matts grade decreased from 3.4 ± 0.5 to 2.2 ± 0.8 (P = 0.02). Six of 7 patients who were on prednisolone upon enrollment in the study were able to discontinue this cortico-steroid. Electron spin resonance revealed that Qing Dai possesses strong hydroxyl radical scavenging activity. Qing Dai showed significant clinical and endoscopic efficacy in patients who failed to respond to conventional medications. Scavenging of hydroxyl radicals appears to be a potential mechanism through which Qing Dai acts, but the significance of the scavenging ability of Qing Dai with respect to the anti-inflammatory effect in UC patients warrants further investigation. © 2013 Baishideng. All rights reserved. Source


Ito H.,University of Tsukuba | Matsui H.,University of Tsukuba | Matsui H.,Kyoto Prefectural University of Medicine | Hirayama A.,Tsukuba University of Technology | And 3 more authors.
Journal of Clinical Biochemistry and Nutrition | Year: 2016

Photodynamic therapy is useful for the treatment of cancer because it is minimally invasive for patients. Certain porphyrin compounds and their derivatives have been used as the photosensitizer because they accumulate specifically in cancerous tissues. However, the detailed mechanism of this phenomenon has not been clarified. We previously reported that a proton-coupled folate transporter, HCP1, transported porphyrins and that regulation of the protein was associated with cancer-specific reactive oxygen species from mitochondria (mitROS). Therefore, over-generation of mitROS could increase HCP1 expression and the effect of photodynamic therapy. We investigated whether pretreatment with indomethacin influenced photodynamic therapy by using a rat normal gastric mucosal cell line, RGM1, its cancer-like mutated cell line, RGK1, and a manganese superoxide dismutase (MnSOD)-overexpressing RGK cell line, RGK-MnSOD. Indomethacin promotes the generation of cellular mitROS by inhibiting the electron transport chain, and MnSOD scavenges the mitROS. We elucidated that indomethacin enhanced cancer-specific mitROS generation and increased HCP1 expression. Furthermore, RGK1 cells showed higher cellular incorporation of hematoporphyrin and better therapeutic effect with indomethacin treatment whereas RGK-MnSOD cells did not show a difference. Thus, we concluded that indomethacin improved the effect of photodynamic therapy by inducing increased mitROS generation in cancer cells. © 2016 JCBN. Source


Itoh Y.,Tsukuba University of Technology
IEICE Transactions on Information and Systems | Year: 2011

This paper introduces a practical color filter array (CFA) interpolation technique. Among the many technologies proposed in this field, the inter-color methods that exploit correlation between color planes generally outperform the intra-color approaches. We have found that the filtering direction, e.g., horizontal or vertical, is among the most decisive factors for the performance of the CFA interpolation. However, most of the state-of-the-art technologies are not flexible enough in determining the filtering direction. For example, filtering only in the upper direction is not usually supported. In this context, we propose an inter-color CFA interpolation using a local map called unified geometry map (UGM). In this method, the filtering direction is determined based on the similarity of the local map data. Thus, it provides more choices of the filtering directions, which enhances the probability of finding the most appropriate direction. It is confirmed through simulations that the proposal outperforms the stateof- the-art algorithms in terms of objective quality measures. In addition, the proposed scheme is as inexpensive as the conventional methods with regard to resource consumption. © 2011 The Institute of Electronics, Information and Communication Engineers. Source


Zhang J.,Tsukuba University of Technology | Tomonaga S.,Drecom Co. | Nakajima S.,Kyoto Sangyo University | Inagaki Y.,Kizasi Company | Nakamoto R.,Kizasi Company
17th International Conference on Information Integration and Web-Based Applications and Services, iiWAS 2015 - Proceedings | Year: 2015

Identifying important users from social media has recently attracted much attention in information and knowledge management community. Although researchers have focused on users' knowledge levels on certain topics or inuence degrees on other users in social networks, previous works have not studied users' prediction ability on future popularity. In this paper, we propose a novel approach to find important bloggers based on their buzzword prediction ability. We conduct a time-series analysis in the blogosphere considering four factors: post earliness, content similarity, entry frequency and buzzword coverage. We perform preparatory work in categorizing a blogger into knowledgeable categories, identifying past buzzwords, analyzing a buzzword's peak time content and growth period, and finally evaluate a blogger's prediction ability on a buzzword and on a category. Experimental results on real-world blog data consisting of 150 million entries from 11 million bloggers demonstrate that the proposed approach can find prophetic bloggers and outperforms others that do not take temporal features into account. © 2015 ACM. Source


Yamamoto N.,University of Tsukuba | Shiroma S.,Joetsu University of Education | Nishioka T.,Tsukuba University of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2013

It is one of the basic approaches to use the graphical representation of problem spaces for the spatial cognition experiments of the hard of hearing students. Virtual items and the virtual space are thought to be used practical both to build up questions and to assemble answers between experimenters and subjects. Objects and their mutual relations are the basic components of structural model that have to be managed for forming problems. The object oriented processing is the significant and useful framework for modern programming languages. An object is theoretically the functional abstract closure. However, the idea of closure can be easily extended to the practical items. In this article, object oriented representation and its applying to constraint relation problem for interactive experiments are discussed. © 2013 Springer-Verlag Berlin Heidelberg. Source


Masaki I.,Tsukuba University of Technology
BioPsychoSocial Medicine | Year: 2015

Background: Although previous studies have shown detrimental effects of visual impairment on health-related quality of life (HRQOL), they were primarily conducted on elderly individuals with visual impairment. The objective of this cross-sectional study was to investigate if HRQOL is impaired in young college students with visual impairment and to explore the relationships between HRQOL and other factors. It was hypothesized that visual impairment is not influential enough to lower the HRQOL of young people due to their better physical fitness and more flexible mentality. Methods: A total of 21 college students (mean age = 25 years old) with varying degrees of visual impairment completed the short form (SF)-36 health survey and questionnaires on daily physical activities. Subjects were grouped depending on the type of visual impairment: blind (n = 11) or severely impaired (n = 10). In addition, grip strength and single-leg standing balance were assessed. Results: No between-group differences were found in the SF-36 scores. However, compared to the general Japanese standards (50.0 ± 10.0), the Vitality scores of the blind group were lower (41.9 ± 7.2, p = 0.004) and the Physical Function scores of the severely impaired group were higher (55.3 ± 2.4, p = 0.001). In addition, a negative correlation was found between standing balance (variability of foot center of pressure) and the Physical Component Summary score of the SF-36 (r2 = 0.35, p = 0.005). Conclusions: These findings suggest that even among young people severe visual impairment leads to reductions in some components of HRQOL. © 2015 Masaki. Source


Kanai Y.,Tokai University | Kanai Y.,Genesia Inc. | Murakami Y.,Tokai University | Murakami Y.,Tsukuba University of Technology | And 2 more authors.
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2011

The photodoping phenomenon of Ag is one of the light induced phenomena in GeS2 amorphous chalcogenide films. Photonic structures like wave guides and micro-optics may be possible to fabricate utilizing the refractive modulation caused by the doping process of Ag, but the practical fabrication method has not been established yet. The method to monitor the doping also has to be paid attention for precise processing. In this report, a dual functional laser scanning system integrating micro-machining and micro-scope systems is proposed. An UV laser, effective for photodoping phenomenon, is used to process the doping patterns, and a VIS laser, not influential upon the material, is used to monitor the fabricated patterns. In-situ nano scale manipulation and observation processes were possible under same setup in one system. As a typical photonic pattern, diffraction gratings of Ag/GeS2 were fabricated and optical performances were evaluated. An optical model of the light propagation in the doped layers is proposed and simulated. The mechanism for the enhanced broadening of the doped region was suggested well through the simulation. This system will open new device fabrication and help to advance the research of nanostructures and photonic crystals. Source


Murakami Y.,Tokai University | Murakami Y.,Tsukuba University of Technology | Iijima T.,Tokai University | Wakaki M.,Tokai University
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2011

The photodoping phenomenon was found by Kostyshin in Russia in 1965. Many researches have carried out studying on the photodoping phenomenon of Ag /a-As2S3 system, and various interesting behaviors have been reported. However, there are few works on the research of the photodoping phenomenon of Ag /a-GeS2 double layer system. It was reported that the lateral diffusion was small at the photodoping phenomenon of Ag /a-GeS 2 system compared with the Ag /a- As2S3 system. Therefore, the feasibility of application for fine patterning is expected for the Ag /a-GeS2 system. In general, a light beam with the photon energy near the optical gap energy (ca. 3.3eV) of a-GeS2 is irradiated to cause photodoping. In this study, the photodoping characteristics of multilayer films, GeS2/Ag/GeS2 and Ag/GeS 2/Ag, were fabricated and characterized. The photodoping characteristics are compared with the conventional two layer films. In the GeS2/Ag/GeS2 three layered system, strong selectivity of photodoping property relating with the incident light wavelength was found. The feasibility to apply three layered films to optical memories and waveguides were suggested. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE). Source


Kuroki H.,Tsukuba University of Technology | Kuroki H.,Utsunomiya University | Ino S.,Japan National Institute of Advanced Industrial Science and Technology | Nakano S.,University of Tokyo | And 5 more authors.
Kyokai Joho Imeji Zasshi/Journal of the Institute of Image Information and Television Engineers | Year: 2011

We have been studying a real-time speech-to-caption system using speech recognition technology with a repeat speaking method. In this system, we used a repeat speaker who listens to a lecturer's voice and then speaks back the lecturer's utterances into a speech recognition computer. Our developing system showed that the accuracy of the captions is about 97% in Japanese-Japanese conversion, and the conversion time from voices to captions is about 4 seconds in English-English conversion in some international conferences. Of course it required a lot of costs to achieve these high performances. In human communications, speech understanding depends not only on verbal information but also on non-verbal information such as speaker's gestures and face and mouth movements. Therefore, we found a suitable way to display the information of captions and speaker's face movement images to achieve higher comprehension after briefly storing information once into a computer. In this paper, we investigated the relationship of the display sequence and display timing between captions that have speech recognition errors and the speaker's face movement images. The results showed that the sequence displaying the caption before the speaker's face image improved the comprehension of the captions. The sequence displaying both simultaneously showed an improvement of only a few percent higher than that of the question sentence, and the sequence displaying the speaker's face image before the caption showed almost no change. In addition, the sequence displaying the caption 1 second before the speaker's face showed the most significant improvement of all the conditions in the hearing-impaired. Source


Suttirojpattana T.,Tsukuba University of Technology | Somfai T.,Japan National Agriculture and Food Research Organization | Matoba S.,Japan National Agriculture and Food Research Organization | Parnpai R.,Suranaree University of Technology | And 2 more authors.
Animal Science Journal | Year: 2016

Our aim was to improve the developmental competence of bovine oocytes during their liquid storage by using additives. In vitro matured oocytes were stored for 20h at 25°C in HEPES buffered TCM 199 medium (base medium). After storage, in vitro embryo development after in vitro fertilization was compared to those of non-stored (control) ones. Addition of 10% (v/v) newborn calf serum or 10.27mmol/L pyruvate alone to the base medium did not improve blastocyst formation rates in stored oocytes; however, their simultaneous addition significantly improved the rate compared with those stored in base medium (P<0.05). Supplementation of the holding medium with dithiothreitol (DTT) at any concentrations did not improve embryo development from stored oocytes. Although supplementation with cyclosporine A (CsA) significantly reduced apoptosis and membrane damage rates during storage, it did not improve the developmental competence of oocytes. 1,2-bis(2-aminophenoxy) ethane N,N,N',N'-tetraacetic acid tetrakis-acetoxymethyl ester and ruthenium red had no effect on oocyte apoptotic rates. Blastocyst formation rates in all stored groups remained significantly lower than that of the control. In conclusion, pyruvate and serum had a synergic effect to moderate the reduction of oocyte quality during storage, whereas mitochondrial membrane pore inhibitor CsA and the antioxidant DTT did not affect their developmental competence. © 2016 The Authors. Animal Science Journal published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Animal Science. Source


Tanno I.,Tsukuba University of Technology | Hashimoto T.,Kinki University | Yasuda T.,University of Shiga Prefecture | Tanaka Y.,Toyo Tire and Rubber Co. | And 2 more authors.
Computers and Fluids | Year: 2013

In this study, the lattice Boltzmann method, pseudospectral method, and artificial compressibility method were implemented on both CPU and GPU machines. Homogeneous isotropic turbulent flows were calculated using these three methods with the C language and CUDA library. The computational results show that the flow field obtained by the lattice Boltzmann method was almost the same as that obtained by the pseudospectral method. Among these three methods, the computational time of the lattice Boltzmann method on a GPU was the shortest of all calculations. Thus, the lattice Boltzmann method was well accelerated by GPUs. These results proved that the lattice Boltzmann method on a GPU has advantages of accuracy and computational speed. © 2012 Elsevier Ltd. Source


Murakami Y.,Tokai University | Murakami Y.,Tsukuba University of Technology | Wakaki M.,Tokai University
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2014

When metal layers like Ag or Cu deposited on the amorphous chalcogenide films such as As2S3, As2Se3, GeS2, and GeSe2, are illuminated by light, the metal elements diffuse abnormally into the amorphous chalcogenide layer. This abnormal diffusion of metal was found by Kostyshin in Russia in 1965 and called photodoping. The large modulation of refractive index is realized by the doping of large amount of Ag atoms into the amorphous network of chalcogenide film which gives the possibility for various photonic device applications. In this study, the quantitative characterization of photodoping phenomena was carried out for amorphous GeS2 films using Ag as a doping metal element to obtain the basic information to the photonic device fabrication. Quantum efficiency to reach the saturation of the doping was derived using the laser diodes with different wavelengths which cause a photodoping phenomenon. As for the wavelength dependence of the photodoping, it was suggested that the quantum efficiency was enhanced for the irradiated photon energy near the optical gap energy (ca. 3.3eV) of a-GeS2 and showed the tendency similar to the absorption spectrum of the amorphous GeS2 film. Photodoping rate was studied for various irradiated power densities of a He-Cd laser (441.5 nm) and the photodoping rate was proportional to the number of incident photons at low intensity. For the intensity over 10mW/cm2, the enhancement of photodoping rate was observed due to some extra effects like a thermal effect. Source


Hashimoto T.,Kinki University | Tanno I.,Tsukuba University of Technology | Tanaka Y.,Toyo Tire and Rubber Co. | Morinishi K.,Kyoto Institute of Technology | Satofuka N.,Kyoto Institute of Technology
Procedia Engineering | Year: 2013

Kinetically Reduced Local Navier-Stokes (KRLNS) equations are applied for two-dimensional (2-D) simulations of Womersley problem and doubly periodic shear layers in order to demonstrate the accuracy, efficiency and the capability to capture the correct transient behavior. The numerical results obtained by the KRLNS equations are compared with those obtained by the pseudo-spectral method (PSM), which is a standard approach to incompressible viscous flows for low Mach number, as well as Lattice Boltzmann Method (LBM). It is confirmed that the KRLNS method can capture the correct transient behavior without use of sub-iterations due to a smoothing effect introduced by using the Grand potential in the continuity equation, and keep the fluctuation of velocity divergence at smaller level by giving an appropriately low Mach number. Parallel computation is carried out on a GPU based on NVIDIA Tesla CI060 system and the provided CUDA library. © 2013 The Authors. Source


Matsubara M.,University of Tsukuba | Oba T.,University of Tsukuba | Kadone H.,University of Tsukuba | Terasawa H.,University of Tsukuba | And 2 more authors.
IEEE Multimedia | Year: 2015

GaitEcho is a wearable auditory biofeedback device that uses an instrumented ankle-foot orthosis for gait rehabilitation. The authors investigated its feasibility for rehabilitating sighted and blind individuals by employing a reference-tracking task for an ankle-joint exercise. Experimental results suggest that GaitEcho offers similarly adequate functionality (angle controllability, timing controllability, and task difficulty) for both blind and sighted participants in conducting ankle-joint exercises. Furthermore, blind participants reported higher understandability and enjoyment than sighted participants, suggesting positive emotional effect of auditory biofeedback for blind users. © 1994-2012 IEEE. Source


Hansen K.F.,KTH Royal Institute of Technology | Hiraga R.,Tsukuba University of Technology | Li Z.,KTH Royal Institute of Technology | Wang H.,KTH Royal Institute of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2013

The Music Puzzle is a computer game for tablets and smartphones using sounds for the gameplay. Just like an original picture is reconstructed from pieces with jigsaw puzzle, an original sound is reconstructed from musical segments with Music Puzzle. Each segment is distorted by shifting the pitch and equalization. To finish the game, the user listens to each segment visualized as pieces on the screen, reorders them, and corrects their pitch and equalization. The game has a possibility for deaf and hard of hearing people to improve their residual hearing ability since the observation shows their concentrating the game with sounds and preference for music. © Springer International Publishing 2013. Source


Kobayashi M.,Tsukuba University of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2010

Wall climbing became more and more popular sports among the visually challenged in these days. They can play and enjoy it together with sighted people without any additional rules. However, severely visually impaired climbers still have a problem. That is a difficulty to know where the climbing hold after next one is in advance. A visually impaired climber champion pointed out that to know the positions of holds of two or three steps ahead is very important and that information will be useful to make a strategy. To solve that problem, a basic inspection of support method is conducted. Web camera, a pair of ultra sonic devices and a bone conduction headphone with Bluetooth technology are tested. The results of these tests and comments by climbers suggested that to make a system which support bouldering using general-purpose equipments is available for the visually challenged climbers. © 2010 Springer-Verlag Berlin Heidelberg. Source


Minatani K.,Entrance | Watanabe T.,Niigata University | Yamaguchi T.,Niigata University | Watanabe K.,Niigata University | And 3 more authors.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2010

The authors have developed a tactile map creation system (TMACS). It is intended to assist blind persons' independent mobility. For this purpose, the system was designed to produce tactile maps, to be manipulated by the blind person and to support producing tactile maps of arbitrary locations of Japan. Through group interviews with blind persons, the authors collected information on what kind of strategies are useful for independent walk and what kind of objects can function as landmarks. TMACS is developed to make good use of these information. From the walking experiment, some assumptions which were made by the authors were confirmed. On the other hand, some unexpected or contradicted results were observed on the usefulness of landmarks and the cause of losing right routes. © 2010 Springer-Verlag Berlin Heidelberg. Source


Ayuzawa S.,Tsukuba University of Technology | Ihara S.,Tokyo Metropolitan Childrens Medical Center | Aoki T.,Tsukuba Central Hospital
Brain and Nerve | Year: 2014

The basic concept of neurosurgical procedures to treat spasticity is to decrease the hyperactivity of the stretch reflex. Selective peripheral neurotomy is a method to partially resect the peripheral motor nerve. The alpha motor and la afferent nerves are resected, but the latter is essential owing to its lasting effect in reducing spasticity. Focal spasticity in adult patients can be effectively treated using peripheral neurotomy. Functional posterior rhizotomy, mostly used to treat paraplegic spasticity in children with cerebral palsy, involves the sectioning of posterior rootlets associated with abnormal motor responses to electrical stimulation. Intrathecal baclofen therapy is useful in treating diffuse spasticity. Baclofen inhibits the activity of alpha motor neurons both pre and post synaptically at the level of the spinal cord. A decrease in Hmax/Mmax in the H-reflex electrophysiologically represents the effectiveness of these procedures. Good clinical results can be achieved by appropriate indication depending on the clinical features of spasticity in each patient. Source


Suzuki T.,Hiroshima Institute of Technology | Araki T.,Hiroshima Institute of Technology | Kawai K.,Hiroshima Institute of Technology | Murai Y.,Nihon Pharmaceutical University | Tatsumi H.,Tsukuba University of Technology
Proceedings - 2013 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2013 | Year: 2013

We have proposed a system, referred to as HALS, which supports visually impaired students in learning science and mathematics by using a haptic device [1]. This article describes the second stage towards HALS. The basic idea of the system is, by taking good advantage of the haptic device, to provide them with haptic perceptions of scientific things such as 3D objects and motions of a body and, through the experience, to enable them to have images of these things in their mind. We expect that such an image of natural things promotes better understanding of science. In this work, we realize partially the above ideas and develop several models which produce virtual things visually handicapped students can perceive by means of the device. Some models produce planar and spatial geometrical objects and others do moving bodies. The efficiency of these models were examined by blind undergraduate students. We finally address merits and demerits of our system, and clarify the points to be improved. © 2013 IEEE. Source


Kanahori T.,Tsukuba University of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2010

We can access to large amounts of information on the web. Searching and getting information has become much more important. Using assistive products, visually impaired people also can access to a goodly portion of them, but getting information they need still takes long time. We introduce our software "Finger Skitter", which is being developed not for reading a document but for getting information with voice navigation. This software provides 2 types of user interface to rapidly get "what the document is written about" and "where is the information in the document". We implement a prototype of the software with JavaScript, which uses live-regions supported in WAI-ARIA to control a speech engine. © 2010 Springer-Verlag Berlin Heidelberg. Source


Miyamoto O.,Tsukuba University of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2010

A special browser is a specialized browser designed only for a specific website, providing a very comfortable user interface for that website. However, it is usually necessary to update the special browser when there is a design change to the website. Therefore, a special browser should be easy to update. I propose such a browser here. The proposed browser also has robustness, meaning that it does not need to be updated for a small change to the website. abstract environment. © 2010 Springer-Verlag Berlin Heidelberg. Source


Akematsu Y.,Tsukuba University of Technology | Kageyama K.,University of Tokyo | Murayama H.,University of Tokyo
Procedia CIRP | Year: 2016

Carbon fiber reinforced plastic (CFRP) is widely used for many structures because of its high strength and rigidity characteristics. Recently, CFRP has been applied as the main structural material in commercial aircraft. However, CFRP is difficult to machine fine process because it consists of hard and soft materials. We have investigated the basic characteristics of EDM on CFRP by using an infrared thermal camera. Processing conditions such as the discharge voltage, current and duration were changed. A gap voltage of several hundred volts results in lightning damage, and a crater forms along the current flow direction. We show that the current flows through the carbon fibers. © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. Source


Sato C.,SBI Net Systems Co. | Okamoto T.,Tsukuba University of Technology | Okamoto E.,University of Tsukuba
International Journal of Applied Cryptography | Year: 2010

In this paper, we construct a strongly unforgeable ID-based signature scheme in the standard model (or without random oracles), with five signature parameters. The signature size of our scheme is smaller than that of other schemes based on varieties of the Diffie-Hellman (DH) problem or the discrete logarithm problem. The security of the scheme relies on the difficulty solving three problems related to the DH problem and a one-way isomorphism. Copyright © 2010 Inderscience Enterprises Ltd. Source


Watanabe M.,Tsukuba International University | Kaneoka K.,Waseda University | Wada Y.,University of Tsukuba | Matsui Y.,University of Tsukuba | And 2 more authors.
Journal of Back and Musculoskeletal Rehabilitation | Year: 2014

BACKGROUND AND OBJECTIVE: Sitting posture may often place large burden on trunk muscles, while trunk muscle activities in the sitting posture have not been well clarified. In this study, a difference in trunk muscle activity between two kinds of sitting postures was evaluated, focusing on low back pain induced by posture holding.MATERIAL AND METHODS: An experiment was conducted on the subjects sitting on a stable-seat and on an unstable-seat, with the pelvis inclined forward, backward, rightward, and leftward.RESULTS: With the pelvis inclined forward, rightward and leftward, muscle activities were significantly increased in a stable-seat sitting posture. In contrast, no significant increase in muscle activity was observed with the pelvis inclined in every direction in an unstable-seat sitting posture.CONCLUSIONS: With the pelvis inclined in the stable-seat sitting posture, muscle activities were imbalanced, while with the pelvis inclined in the unstable-seat sitting posture, muscle activities were not imbalanced. Thus, it is suggested that with the pelvis inclined to the maximum extent in the stable-seat sitting posture, low back pain may be induced by imbalanced muscle activities. © 2014 IOS Press and the authors. All rights reserved. Source


Namatame M.,Tsukuba University of Technology | Kitajima M.,Japan National Institute of Advanced Industrial Science and Technology
Proceedings of the IADIS International Conference e-Learning 2011, Part of the IADIS Multi Conference on Computer Science and Information Systems 2011, MCCSIS 2011 | Year: 2011

This paper reports on experiments investigating how hard-of-hearing students use e-learning education material for procedure learning and suggests requirements of usable e-learning material for these students. For the experiment, we developed course material that consists of an instruction window displaying balloon instructions and demonstrations, and a workspace window where the learners replicate the demonstrated operations. We recorded the eye movements of 20 hard-of-hearing students and 20 normal-hearing students while they were using the experimental course material, and investigated their use of the balloon instructions. We transcribed their interaction in terms of 32 operations categorized in four classes: 1) eye movement without operation, 2) instruction reading, 3) instruction control, and 4) operation on the workspace. We found that even if they accomplished the course material objectives, hard-of-hearing students did not use the material as the designer intended, i.e., 1) observe demonstration, 2) read balloon instruction, 3) stop the movie, 4) reproduce the demonstration on the work window, 5) restart the material. Possible improvements include providing a list of procedures or stopping the material before proceeding to the next unit and having the students select "replay" or "proceed." © 2011 IADIS. Source


Sato T.,Tokyo Medical University | Ito M.,Tojun Hospital | Sakamoto H.,Tsukuba University of Technology
Surgical and Radiologic Anatomy | Year: 2013

Purpose: This photographic review of actual dissections was compiled to demonstrate the various lymphatic pathways and their relationships to the surrounding structures to facilitate the development of QOL surgical procedures. Methods: For the purpose of demonstration, three male adult specimens, prepared with 10 % formaldehyde solution injected through the femoral artery and preserved in 60 % alcohol solution, were used. Dissection was carried out in typical fashion without the use of dyes or a microscope. The dissection results were recorded in sketches, photographs and video recording. Results: Two major lymphatic pathways from the gallbladder are demonstrated: (a) the left oblique pathway to the celiac nodes, and (b) the right descending pathway to the superior retropancreaticoduodenal node (Rouvière). A third and minor pathway to the superior mesenteric nodes is suggested. Conclusions: These three pathways finally reach the para-aortic (lumbar) lymph nodes. The importance of the interaorticocaval nodes at the level of the left renal vein should be emphasized, in particular the significance of the nodes of the right descending pathway, from the viewpoint of surgical treatment of cancer of the gallbladder and the pancreas head. © 2013 Springer-Verlag France. Source


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Ohkoshi N.,Tsukuba University of Technology | Ishii A.,University of Tsukuba
Neuro-Ophthalmology Japan | Year: 2014

Mitochondrial disease is a diverse group of disorders resulting from dysfunction of the respiratory chain, which is under the dual control of nuclear and mitochondrial DNA. The most commonly affected organ systems are muscles, the central nervous system, and the cardiac system. Mitochondrial myopathy selectively affects the extraocular muscles and/or limb and axial muscles. Ocular myopathy, which is manifested by slowly progressive ptosis and ophthalmoplegia, is an important feature in diagnosing mitochondrial disease. Limb muscle weakness is usually proximal but occasionally affects distal muscles as well. One of the most common muscular symptoms is exercise intolerance due to premature fatigue during activities. The exercise intolerance is disproportionately severe relative to muscle weakness. Bulbar muscle symptoms, such as dysphagia and dysarthria, occur in advanced cases. Serum and cerebrospinal fluid lactate and pyruvate ratios are an important screening tests for early diagnosis. Muscle biopsies typically show ragged-red fibers and cytochrome c oxidase-deficient fibers. MRI demonstrates stroke-like lesions in patients with MELAS and the atrophy of the cerebrum and cerebellum in MERRF. The identification of causative molecular defects in mitochondrial DNA and nuclear DNA enables a definitive diagnosis. Source


Igarashi A.,University of Tsukuba | Mori M.,University of Tsukuba | Nitta S.-Y.,Tsukuba University of Technology
AIP Conference Proceedings | Year: 2014

Galactic winds are widely recognized as important ingredients in galaxy evolution, and they impact the chemical enrichment of galaxies and the intergalactic medium. We investigate the acceleration process of isothermal, spherically symmetric steady galactic outflows in an appropriate galactic gravitational potential applying the transonic analysis which is the well-known approach for the solar wind. The results show that the transonic solutions of the galactic winds critically depend upon the mass distribution in a galaxy such as the dark matter halo (DMH) and the central super massive black hole (SMBH). We discover the existence of two types of transonic solutions in the gravity from the combination of DMH and SMBH. The first one is accelerated near the SMBH which is similar to the Parker solution, and the other is slowly accelerated over the entire region of DMH. These two transonic solutions have different mass fluxes and starting points. Therefore, they have different influences to the chemical evolution of galaxies and intergalactic space. We have found that the mass fluxes of two transonic solutions are considerably different by several orders of magnitude in spite of the same mass distribution. This result indicates that mass flux is very sensitive not only to the mass distribution but also to the chosen transonic solution. © 2014 AIP Publishing LLC. Source


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Makino Y.,University of Tsukuba | Noguchi E.,University of Tsukuba | Takahashi N.,University of Fukui | Matsumoto Y.,University of Tsukuba | And 12 more authors.
Journal of Allergy and Clinical Immunology | Year: 2010

Background: Allergic rhinitis is a global health problem that causes major illnesses and disability worldwide. Allergen-specific immunotherapy (SIT) is the only available treatment that can alter the natural course of allergic disease. However, the precise mechanism underlying allergen-SIT is not well understood. Objective: The aim of the current study was to identify protein expression signatures reflective of allergen-SIT - more specifically, sublingual immunotherapy (SLIT). Methods: Serum was taken twice from patients with seasonal allergic rhinitis caused by Japanese cedar: once before the pollen season and once during the season. A total of 25 patients was randomly categorized into a placebo-treated group and an active-treatment group. Their serum protein profiles were analyzed by 2-dimensional electrophoresis. Results: Sixteen proteins were found to be differentially expressed during the pollen season. Among the differentially expressed proteins, the serum levels of complement C4A, apolipoprotein A-IV (apoA-IV), and transthyretin were significantly increased in SLIT-treated patients but not in placebo-treated patients. Among these proteins, the serum levels of apoA-IV correlated with the clinical symptom-medication scores (r = -0.635; P < .05) and with quality of life scores (r = -0.516; P < .05) in the case of SLIT-treated patients. The amount of histamine released from the basophils in vitro was greatly reduced after the addition of recombinant apoA-IV in the medium (P < .01). Conclusion: Our data will increase the understanding of the mechanism of SLIT and may provide novel insights into the treatment of allergic rhinitis. © 2010 American Academy of Allergy, Asthma & Immunology. Source


Marushima A.,University of Tsukuba | Suzuki K.,University of Tsukuba | Suzuki K.,Dokkyo Medical University | Nagasaki Y.,University of Tsukuba | And 7 more authors.
Neurosurgery | Year: 2011

BACKGROUND: Antioxidant nitroxyl radicals such as 2,2,6,6- tetramethylpiperidine-1-oxyl (TEMPO) have been investigated for their ability to scavenge free radicals produced by ischemia-reperfusion injury. However, the short in vivo half-life and toxicity of TEMPO have limited their clinical application. OBJECTIVE: We developed a core-shell-type nanoparticle, termed a radical-containing nanoparticle (RNP), to deliver nitroxyl radicals with prolonged in vivo half-life and pH-sensitivity. We evaluated the ability of RNP to deliver TEMPO radicals to the ischemic brain and scavenge free radicals in cerebral ischemia-reperfusion injury using rats. METHODS: When RNPs were administrated to middle cerebral artery occlusion rats, the delivery and clearance of RNPs were detected using electron paramagnetic resonance (EPR) assay. The production of superoxide anion in neuronal cells was observed with dihydroethidium staining. The treatment effects were evaluated by measuring the cerebral infarction volumes, lipid peroxidation and protein oxidation, and neurological symptom scoring. RESULTS: The TEMPO radicals contained in RNPs were detected for 6 hours after intravenous administration as a triplet EPR signal in the ischemic brain, and RNPs significantly reduced the production of superoxide anion in neuronal cells compared with saline and 4-hydroxy-2,2,6,6- tetramethylpiperidine-1-oxyls (TEMPOL). The infarction volumes of rats treated by RNPs were significantly lower than those of rats treated by saline, micelles, and TEMPOL. In addition, RNP treatment suppressed lipid peroxidation and protein oxidation, and limited the adverse effects of TEMPO radicals such as hypotension. CONCLUSION: RNPs could be a promising neuroprotective agent with their enhanced ability to scavenge free radicals and reduced toxicity. Copyright © 2011 by the Congress of Neurological Surgeons. Source


Patent
University of Tsukuba and Tsukuba University of Technology | Date: 2013-02-06

Provided is an organic-inorganic hybrid composite of a polymerized cyclic nitroxide radical compound and inorganic nanoparticles. Such a composite is capable, for example, of maintaining a stable nanoparticle shape in gastric fluid, and can be used by itself or as a carrier for delivery of another drug to the intestines.


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Miura T.,Tokyo University of Information Sciences | Miura T.,Japan National Institute of Advanced Industrial Science and Technology | Sakajiri M.,Tsukuba University of Technology | Eljailani M.,Tsukuba University of Technology | And 3 more authors.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2014

Regardless of the improvement of accessibility functions, people with visual impairments have problems using touchscreen computers. Though the size of accessible objects may differ for visually impaired users because of the manipulations under screen readers are different from those without screen readers, the characteristics of desired objects and useful gestures on the touchscreen computers for the visually impaired remain unclear. In this paper, our objective is to clarify the accessible single button characteristics and preferable gestures for visually impaired users of touchscreen computers. We studied these characteristics by evaluating the single button interaction of touchscreen interfaces for visually impaired people under a screen reader condition. As a result, the performance of task completion time on selecting task with a single button decreased as the button size became larger; they were ranked in descending order of double-tapping after flicking, double-tapping after tracing, and split-tapping after tracing. © 2014 Springer International Publishing. Source


Miura T.,University of Tokyo | Miura T.,Japan National Institute of Advanced Industrial Science and Technology | Ebihara Y.,Tsukuba University of Technology | Sakajiri M.,Tsukuba University of Technology | Ifukube T.,University of Tokyo
Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics | Year: 2011

The visually-impaired people have the difficulty on perceive the largeness of a space and objects existed in a space by means of visual information. Particularly auditory-trained visually-impaired people can recognize 3-D spatial information with environmental sounds. However, systematic learning method of auditory training for acquired visually-impaired is not established sufficiently because the self-experience of the visually-impaired people is the main reason of ability acquisition in the actual environment because they do not have enough information about moving in the real environment. In this paper, the authors aim at demonstrating moving situations and moving needs of the visually-impaired, for example, which acoustical factors can be used in some living situation, what kind of environmental situation they think it difficult to perceive silent objects and what kind of aid they need. Results indicated following facts: Totally visually-impaired people tend to get more spatial information from auditory than not-totally visually-impaired people. Regarding available auditory cues, items of rotating head in order to listen carefully to environmental sound, and hitting floors stronger by a white cane or foot for voluming up reflected or reverberated sounds were much selected by the totally visually-impaired participants who can perceive obstacles with auditory information. Result of question about conventional devices indicated that most totally visually-impaired participants selected electrical sounding device informing obstacle distance, while most not-totally visually-impaired participants selected vibrating device informing the distance of walls or doors and tactually-stimulated device informing obstacle distance. © 2011 IEEE. Source


Miura T.,Tokyo University of Information Sciences | Miura T.,Japan National Institute of Advanced Industrial Science and Technology | Sakajiri M.,Tsukuba University of Technology | Matsuzaka H.,Tsukuba University of Technology | And 5 more authors.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2014

This paper demonstrates the usage of touchscreen interfaces in the Japanese visually impaired population by means questionnaire surveys conducted in 2011, 2012, and 2013. In 2011 and 2013, we carried out usage situations of touchscreens and the reasons why some of them did not use it. The surveys in 2012 and 2013 comprised the questionnaire items regarding specific manipulation situations of touchscreens. Some of the results indicate that an increasing number of visually impaired people used and required to use touchscreen computers; some of them did not want to use it because they were satisfied with conventional cell phones, and because they are waiting for the device which can feedback tactually; the users of touchscreen computers with total and partial vi- sual impairments mainly uses double-tapping after tracing for selecting buttons and objects; The proper uses and manipulations of smartphones and tablet computers mainly depends on the application usability and the screen size, respectively. © 2014 Springer International Publishing. Source


Yamaguchi M.,Meiji University | Yamaguchi M.,Tsukuba University of Technology | Nakata T.,Japan National Institute of Advanced Industrial Science and Technology | Okamoto T.,Tsukuba University of Technology | Kikuchi H.,Meiji University
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2014

We propose a new scheme of CAPTCHA that does not become a perceptual barrier for disable people. Our CAPTCHA system generates the tests in verbal style, so its use is not limited in specific perceptual channels. The tests are composed of several phrases and there are two kinds of tests: Human users try to (1) distinguish a phrase of strange meaning from others, and (2) identify the common topic among them.In our test we utilize open documents for material. Note that there is quite a large amount of documents on the net, so we can generate brand-new tests every time. One may say that adversaries can look for the phrases over the Internet and get several hints. Our system hides the sources by substituting the consonants of the phrases against such an attack.The mechanism is designed to imitate the phenomenon called "consonant gradation" of natural languages. © 2014 Springer International Publishing. Source


Ito H.,University of Tsukuba | Matsushita S.,University of Tsukuba | Matsushita S.,Tsukuba University of Technology | Hyodo K.,High Energy Accelerator Research Organization | And 2 more authors.
Journal of Synchrotron Radiation | Year: 2013

Owing to limitations in spatial resolution and sensitivity, it is difficult for conventional angiography to detect minute changes of perfusion in diffuse lung diseases, including pulmonary emphysema (PE). However, a high-gain avalanche rushing amorphous photoconductor (HARP) detector can give high sensitivity to synchrotron radiation (SR) angiography. SR angiography with a HARP detector provides high spatial resolution and sensitivity in addition to time resolution owing to its angiographic nature. The purpose of this study was to investigate whether this SR angiography with a HARP detector could evaluate altered microcirculation in PE. Two groups of rats were used: group PE and group C (control). Transvenous SR angiography with a HARP detector was performed and histopathological findings were compared. Peak density of contrast material in peripheral lung was lower in group PE than group C (p < 0.01). The slope of the linear regression line in scattering diagrams was also lower in group PE than C (p < 0.05). The correlation between the slope and extent of PE in histopathology showed significant negative correlation (p < 0.05, r = 0.61). SR angiography with a HARP detector made it possible to identify impaired microcirculation in PE by means of its high spatial resolution and sensitivity. © 2013 International Union of Crystallography. Source


Watanabe K.,Tokyo University of Science | Watanabe K.,Japan National Institute of Advanced Industrial Science and Technology | Watanabe K.,Japan Science and Technology Agency | Matsuda T.,Tamagawa University | And 2 more authors.
PLoS ONE | Year: 2011

Knowing where people look when viewing faces provides an objective measure into the part of information entering the visual system as well as into the cognitive strategy involved in facial perception. In the present study, we recorded the eye movements of 20 congenitally deaf (10 male and 10 female) and 23 (11 male and 12 female) normal-hearing Japanese participants while they evaluated the emotional valence of static face stimuli. While no difference was found in the evaluation scores, the eye movements during facial observations differed among participant groups. The deaf group looked at the eyes more frequently and for longer duration than the nose whereas the hearing group focused on the nose (or the central region of face) more than the eyes. These results suggest that the strategy employed to extract visual information when viewing static faces may differ between deaf and hearing people. © 2011 Watanabe et al. Source


Onishi J.,Tsukuba University of Technology | Sakajiri M.,Tsukuba University of Technology | Miura T.,Tokyo University of Information Sciences | Miura T.,Japan National Institute of Advanced Industrial Science and Technology | Ono T.,Tsukuba University of Technology
Proceedings - 2013 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2013 | Year: 2013

The touchscreens of recent years are used in variety of purposes, since it can implement a switch to the software that can control easily and cheaply as well as present visual images at the same time. Traditional switch had physical shape and tactile feel, which made it possible to find and operate by touch, but with touchscreen type switch, the texture would be uniform all over like the surface of a glass, so in order to operate the switch, one has to gaze at the image. This presents a huge obstacle to visually impaired or aged persons who cannot easily access visual information. On the other hand, the technology to bring about virtual reality with haptic feedback is beginning to be noticed, and touchscreens with haptic feedback functions are gradually becoming viable. So in this paper, based on the assumption that in the coming days securing accessibility will be achieved by using haptic perception, human's virtual haptic information differentiation accuracy and memory will be examined, using touchscreens with haptic feedback function. The main focus will be on the result of fundamental study carried out with visually impaired persons. © 2013 IEEE. Source


Miura T.,Tokyo University of Information Sciences | Miura T.,Japan National Institute of Advanced Industrial Science and Technology | Matsuzaka H.,Tsukuba University of Technology | Sakajiri M.,Tsukuba University of Technology | Ono T.,Tsukuba University of Technology
Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics | Year: 2012

Along with the spread of touchscreen computers, the accessibility of the touchscreen interfaces should be secured for visually impaired people. Some of them had interest and own touchscreen computers, usage condition and needs of the computer was not investigated. Specifically, following situations concerning touchscreen computers remain unknown: what kind of inconvenience they found in their using, what kind of functions they need, why some of them avoid using regardless of their interest, etc. In order to propose and familiarize user-friendly interface for visually impaired people, it is necessary not only to research accessible touchscreen computer but also to investigate current situation regarding touchscreen computers. In this paper, we aimed at demonstrating the needs and usages of touchscreen interfaces such as smartphones and tablet computers in people with visual impairment. These situations are investigated through a questionnaire for Japanese visually impaired people. Part of the results indicated that most of them would like to use touchscreen computer, that most of owners uses by means of screen readers regardless of their visual conditions, and that dynamic and even stable tactile feedback can be effective. © 2012 IEEE. Source


Hasegawa S.,Ouunkai | Sasaki N.,Tsukuba University of Technology | Harakawa T.,Maebashi Institute of Technology
2013 IEEE 2nd Global Conference on Consumer Electronics, GCCE 2013 | Year: 2013

Body-Braille is a mechanism for presenting one Braille cell using micro-vibrators on any part of the body. One application of Body-Braille is the Helen Keller Phone system which is a communication system for deaf-blind people. It is currently in the commercial stage. Since it is expected that users of Body-Braille will increase in number, a self-learning system for Body-Braille is required. Moreover, such a self-learning system must be easy for deaf-blind users to use. In this paper, we describe a wireless device which we have developed for this purpose and details of a self-learning system for Body-Braille. In order to test the system, we performed an experiment in which 14 subjects recognized Body-braille patterns in the first stage of self-learning. The recognition rate was 74.1%. However, postexperiment interviews revealed a keystroke issue that if corrected, would yield a 92.0% recognition rate. © 2013 IEEE. Source


Sasaki N.,Tsukuba University of Technology | Nakajima K.,Tsukuba University of Technology | Ishii K.,Ishii Laboratory | Harakawa T.,Maebashi Institute of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2014

We have been studying the Body-Braille system that transmits Braille characters to disabled people through vibrations on any part of the body. Two years ago, we began to use a SMA (Shape Memory Alloy) device instead of a micro-vibrator. As a result, several advantages were obtained such as smaller equipment size, high resolution transmission, and low power consumption. This year, we developed test equipment for the SMA device which can supply flexible PWM (Pulse Width Modulation) parameters and performed several tests for Braille reading. The test results reveal several possibilities for using a SMA device as a communication channel. © 2014 Springer International Publishing. Source


Sasaki N.,Tsukuba University of Technology | Hasegawa S.,Ouunkai | Harakawa T.,Maebashi Institute of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2012

In this paper, two new Body-Braille devices are described. After the Body-Braille system and its current development status is explained, first, a new device for Braille-based real-time communication over internet (via Skype) is introduced and second, a new device for autonomous learning, which adopts wireless communication, is explained. The former is already developed and being used in the field test stage; the latter one is being developed now. © 2012 Springer-Verlag. Source


Nakadai T.,Tokyo University of Science | Taguchi T.,Tokyo University of Science | Mizoguchi H.,Tokyo University of Science | Egusa R.,Kobe University | And 6 more authors.
2014 IEEE International Conference on Robotics and Biomimetics, IEEE ROBIO 2014 | Year: 2014

We developed a sound separation system that uses a microphone array to separate children's voices from background noise in general living environments. Our focus in the development of this system is on 'a clear separation of the human voice' so that it will be easy for children to use. Evaluations conducted of sound separation performance in previous research have not always measured how easily listeners hear separate sounds. In this paper, we examine the validity of our system design by evaluating this factor from the perspectives of engineering and psychology. © 2014 IEEE. Source


Sasaki N.,Tsukuba University of Technology | Hasegawa S.,Ouunkai | Harakawa T.,Maebashi Institute of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2010

We have developed a musical score system for visually impaired people and deaf-blind people using Body-Braille. The normal musical score is very convenient for non-disabled people, but it is difficult for disabled people to use it. In order to resolve this issue, 9 micro vibrators are used to express the note and the duration time of each sound, which we call "vibration score system". This system is very suitable not only for the study of a melody but also for disabled people's reference while playing. We performed several experiments with a subject, and in each case, we obtained successful results. © 2010 Springer-Verlag Berlin Heidelberg. Source


Donoyama N.,Tsukuba University of Technology | Hotoge S.,University of Tsukuba | Ohkoshi N.,Tsukuba University of Technology
Acupuncture in Medicine | Year: 2011

A 26-year-old top female athlete (height 157 cm), who took part in competitive sport similar to middle- and long-distance running, became amenorrhoeic in February 2009. In late May 2009, athletic amenorrhoea was diagnosed and a norgestrel-ethinyl estradiol combination (norgestrel 0.5 mg and ethinyl estradiol 0.05 mg three times daily) was prescribed for 2 weeks. She experienced menstrual bleeding on one occasion for 4 days in mid-June before becoming amenorrhoeic again. The athlete visited our centre to try acupuncture treatment. Forty-six acupuncture sessions were given between 1 October 2009 and 2 November 2010. Acupuncture point selection was based on classical acupuncture medicine and included points long used for gynaecological disorders in Japan-namely, CV6, CV12, LR3, LR14, BL17, BL18, BL23, SP6 and SP10. On 7 May 2010, owing to lack of regular normal vaginal bleeding, she again consulted her gynaecologist and was prescribed the same hormone preparation as used previously. She took it for 2 weeks in conjunction with acupuncture treatment. From July, the amount and duration of menstrual fl ow increased at regular intervals. Throughout July, a biphasic pattern in basal body temperature (BBT) was gradually established. In conclusion, the single hormone replacement therapy in May 2009 without acupuncture treatment was not effective for the amenorrhoea, nor was the single acupuncture treatment between October 2009 and May 2010. However, after hormone replacement therapy was started in May 2010 in conjunction with regular acupuncture treatment, menstrual blood fl ow restarted and BBT moved close to the biphasic pattern. Source


Sasaki N.,Tsukuba University of Technology | Hasegawa S.,Ouunkai | Harakawa T.,Maebashi Institute of Technology
2012 IEEE Consumer Communications and Networking Conference, CCNC'2012 | Year: 2012

We introduce and demonstrate the "Helen Keller Phone" system, which enables deaf-blind people to communicate with each other without any support person and talk over the telephone for free with Skype. All communication is done via Body-Braille and is analogous to audio chat communication by non-disabled people. Real-time conversation using Braille instead of audio signals is possible and would dramatically improve deaf-blind people's quality of life. The Body-Braille system, which presents one Braille cell using six micro vibrators, has been introduced twice in previous CCNCs. This time we will present newly developed equipment which is very small and portable and includes a new presentation method for Braille cells using only two vibrators, called the "two point system". This new equipment makes portable use possible. We will demonstrate Braille-based communication through Skype, where one user is at home, the other is on the road. © 2012 IEEE. Source


Sakajiri M.,Tsukuba University of Technology | Miyoshi S.,Tsukuba University of Technology | Nakamura K.,Tokyo University of Science | Fukushima S.,Tokyo University of Science | Ifukube T.,University of Tokyo
Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics | Year: 2011

It is difficult for the deafblind or the hearing impaired to control the pitch of their voice because they cannot perceive it. In particular, when singing, it is very difficult for them to control their voice pitch because they need to maintain a stable tone. We have developed a voice pitch control system to assist their singing by means of a tactile display. Using this tactile feedback system, we verified in a previous study that two deafblind subjects were able to control the pitch of their voices with as much accuracy as hearing children. By using this tactile feedback system, the correspondence between musical scale and proprioceptive sensation (muscular sensation and so on) of the two subjects was returned to pre-hearing loss levels. They sung using not only tactile feedback but also proprioceptive feedback. In this paper, we investigate the ability of hearing subjects to control the pitch of their voice, without auditory feedback, using our tactile feedback system. Seven hearing participants were examined under two conditions - "without tactile feedback" and "with tactile feedback" - to ascertain their abilities to control their pitch while subjected to masking noise. The results indicated hearing subjects could not sing with accurate pitch using only proprioceptive feedback ("without tactile feedback" condition). © 2011 IEEE. Source


Ohashi T.,Tsukuba University of Technology | Miura T.,University of Tokyo | Sakajiri M.,Tsukuba University of Technology | Onishi J.,Tsukuba University of Technology | Ono T.,Tsukuba University of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

Accessibility functions on touchscreen computers improved user experience of people with visual impairments. Regardless of this situation, they have some problems using touchscreen interfaces including smartphones and tablets. The reason includes the arrangements of accessible objects may differ for visually impaired users because of the manipulations under screen readers are different from those without screen readers, the characteristics of desired object sizes and arrangements on the touchscreen computers for the visually impaired remain unclear. The purpose of this research is to find a way for the visually impaired to accurately and efficiently manipulate the keyboard. This study especially seeks to find the optimum conditions for the number and sizes of buttons (including the area) for the visually impaired. For this purpose, we developed an experimental application. © Springer International Publishing Switzerland 2016. Source


Matsuo M.,Tsukuba University of Technology | Miura T.,University of Tokyo | Sakajiri M.,Tsukuba University of Technology | Onishi J.,Tsukuba University of Technology | Ono T.,Tsukuba University of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

Although many computer games have recently become diversified, plenty of effort and ingenuity is needed to produce games that persons with a total visual impairment can enjoy. Though some games for visually impaired persons have been developed, games that use only auditory information present challenges for sighted persons. Moreover, unfortunately, it is still difficult for visually impaired persons to play the same game with sighted persons and for sighted and visually impaired persons to share a common subject. To solve this problem, we developed a barrier-free game that both sighted and visually impaired persons can play using their dominant senses including visual, auditory and tactile senses. Moreover, we developed a map editor for a game developer with blindness and provided an integrated game development environment for them. In this paper, we describe the development and reflections of the barrier-free game and the map editor. © Springer International Publishing Switzerland 2016. Source


Onishi J.,Tsukuba University of Technology | Sakai T.,NHK Engineering System | Sakajiri M.,Tsukuba University of Technology | Ogata A.,Tsukuba University of Technology | And 5 more authors.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

In most of cases, communications based on multimedia form is inaccessible to the visually impaired. Thus, persons lacking eyesight are eager for a method that can provide them with access to progress in technology. We consider that the main important key for inclusive education is to real-timely provide materials which a teacher shows in a lesson. In this study, we present tactile sense and kinesthetic sense assisting system in order to provide figure or graphical information without an any assistant. This system gives us more effective teaching under inclusive education system. © Springer International Publishing Switzerland 2016. Source


Onishi J.,Tsukuba University of Technology | Sakajiri M.,Tsukuba University of Technology | Miura T.,Tokyo University of Information Sciences | Ono T.,Tsukuba University of Technology
Proceedings - 2015 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2015 | Year: 2015

The role of human sight becomes increasingly important as information technology progresses. Presentations based on multimedia help to explain many kinds of situations. However, this form of communication, so convenient for persons gifted with sight, is inaccessible to the visually impaired. Thus, persons lacking eyesight are eager for a method that can provide them with access to progress in technology. In education, the presentation of lecture materials involves a lecture focused on oral explanation with the use of compensating information through information technology, however, the lecturer is unable to confirm which part of the materials the students are accessing, and conversely it is not easy to direct the students to access the part on which the lecturer is currently focusing. In this paper, we propose terminal operation learning software which provides more effective to easy access many console messages under inclusive education system. © 2015 IEEE. Source


Minami K.,Kyoto Sangyo University | Wakamiya S.,University of Hyogo | Hata N.,Kyoto Sangyo University | Kawai Y.,Kyoto Sangyo University | And 3 more authors.
Lecture Notes in Engineering and Computer Science | Year: 2014

We have developed a novel system for comprehensive Web search considered the diversity of sentiments. Recently, lots of studies and services based on sentiment analysis have been conducted, because it is still difficult to search and summarize information satisfying users' needs by text analysis only. In this paper, we propose a method to extract multidimensional sentiments of Web pages on a topic such as "Happy⇔Sad," "Glad⇔Angry," and "Peaceful⇔Strained." Specifically, the system can extract common sentiments for a topic and also retrieve and present various Web pages based on comprehensive sentiments. In the experiment, we evaluate our proposed method using the developed system. Source


Tani T.,Tsukuba University of Technology | Gotoh H.,Tsukuba University of Technology | Kuwabara Y.,Technocoa | Aoshima S.,Technocoa | And 2 more authors.
16th International Symposium on Electromachining, ISEM 2010 | Year: 2010

This paper describes surface modification and surface deposition using a high peak current discharge in an air gap. The process of this method is controlled manually using a rotating tool. The discharge circuit is an RC circuit, and switching is executed by means of a thyristor. The deposition of nickel onto a steel surface was carried out using a nickel-based alloy for the electrode. The influence that the capacitance of the capacitor and the diameter of the electrode had on deposition was investigated. In addition, surface deposition using a mask of an arbitrary shape was performed, and partial surface deposition was achieved. Source


Sakajiri M.,Tsukuba University of Technology | Miyoshi S.,Tsukuba University of Technology | Onishi J.,Tsukuba University of Technology | Ono T.,Tsukuba University of Technology | Ifukube T.,University of Tokyo
IEEE SSCI 2014 - 2014 IEEE Symposium Series on Computational Intelligence - CIR2AT 2014: 2014 IEEE Symposium on Computational Intelligence in Robotic Rehabilitation and Assistive Technologies, Proceedings | Year: 2014

Deafblind and hearing impaired persons cannot perceive their own voice pitch, and thus have difficulty controlling it. While singing, the voice pitch needs to be controlled to maintain a stable tone. To address this problem, a tactile voice pitch control system was developed to assist such people in singing. In a previous study, two deafblind subjects used the proposed system to control their voice pitch with accuracy comparable to that of the hearing children. In the present study, we investigate the proprioceptive pitch control and the effect of the proposed voice pitch control system on normal-hearing people under conditions of added noise. The results show that the total average mean deviation without tactile feedback is 405.6 cents (SD: 42.4), whereas, with tactile feedback, it is 57.5 cents (SD: 12.2). © 2014 IEEE. Source


Onishi J.,Tsukuba University of Technology | Miura T.,Tokyo University of Information Sciences | Sakajiri M.,Tsukuba University of Technology | Ono T.,Tsukuba University of Technology
Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics | Year: 2014

Through the development of information technology in recent years, it is now common for lectures to involve education using PowerPoint materials and similar. Likewise, in education for the visually impaired, the presentation of lecture materials involves a lecture focused on oral explanation with the use of compensating information through information technology; however, the lecturer is unable to confirm which part of the materials the students are accessing, and conversely it is not easy to direct the students to access the part on which the lecturer is currently focusing. Here, in this paper, I present an experimental software through which lecture materials are distributed to students via a TCP/IP network, in which the lecturer can instruct the students which items to focus on and the students can immediately confirm these through screen readers. © 2014 IEEE. Source


Zhang J.,Tsukuba University of Technology | Minami K.,Kyoto Sangyo University | Kawai Y.,Kyoto Sangyo University | Shiraishi Y.,Tsukuba University of Technology | Kumamoto T.,Chiba Institute of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2013

Re-ranking and re-retrieval of search results are useful techniques for satisfying users' search intentions, since current search engines cannot always return user-desired pages at the top ranks. In this paper, we propose a system for personalized Web search considering users' emotional aspects. Given a query topic, the system presents the major emotion tendency on this topic that search results returned from search engines are reflecting. The system also enables users to specify the polarities and strengths of their emotions (e.g., happy or sad, glad or angry, peaceful or strained) on this topic and offers a re-ranking list of initial search results based on the similarity of emotions. Particularly, the system can automatically obtain Web pages with minor emotion tendency on the query topic by extracting sub-queries with opposite emotions and conducting a re-retrieval. Experimental evaluations show the re-ranking and the re-retrieval achieve encouraging search results in comparison with initial search results. © 2013 IFIP International Federation for Information Processing. Source


Sakajiri M.,Tsukuba University of Technology | Miyoshi S.,Tsukuba University of Technology | Nakamura K.,Tsukuba University of Technology | Fukushima S.,Tokyo University of Science | Ifukube T.,University of Tokyo
Proceedings - 2013 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2013 | Year: 2013

Deafblind and hearing impaired persons cannot perceive their own voice pitch and thus find it difficult to control. While singing, the voice pitch needs to be controlled to maintain a stable tone. Hence, a voice pitch control system was developed to assist such persons in singing. In a previous study, two deafblind subjects using this system could control their voice pitch with comparable accuracy as hearing children while singing "Frog Round," even though successive notes in the song' melody were adjacent in the musical scale. Herein, the pitch control accuracy is investigated for "Frog Round," and song in which successive notes are separated by wider intervals in the musical scale, for comparison. No tendency is found in the interval deviations of the pitch for different musical notes or changes in the musical interval. The effect of changes in melody on accuracy will be investigated in a future work. © 2013 IEEE. Source


Gotoh H.,Tsukuba University of Technology | Tani T.,Tsukuba University of Technology | Mohri N.,University of Tokyo
Procedia CIRP | Year: 2016

Electrical discharge machining (EDM) is available and effective for precise, complex shaping. Recently, by using the assisting electrode method, EDM can be applied to insulating ceramics. In this method, a pulse discharge that is longer than the set pulse duration is generated. With this long pulse discharge, an electrical conductive layer is formed on the surface of the insulating ceramic, which maintains stable machining. In this paper, we describe how to control this electrical conductive surface layer. The layer control sequence is applied to the wire electrical discharge milling method (WED-milling) with a wire guide on a hemisphere tip in order to realize 3D machining of insulating ceramics. © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. Source


Tani T.,Tsukuba University of Technology | Gotoh H.,Tsukuba University of Technology | Hirao A.,Niigata University | Mohri N.,University of Tokyo
Procedia CIRP | Year: 2016

In this paper, we propose the simultaneous machining of a polygonal microelectrode and microholes using a tandem electrical discharge machining (EDM) mechanism. Two types of power sources for forming the polygonal pillar electrode and hole machining were installed on the same machine. A mask plate with the target shape is used to form the electrode. Planar motion was applied to the mask plate, and a polygonal micropillar electrode was produced by reducing operation. In this process, the low wear condition of the mask plate and the high wear condition of the electrode were chosen. Zinc alloy, which is easy to form by EDM, was used for the electrode material. After the electrode was formed, polygonal microholes were drilled into a tungsten plate using this electrode. Microhole machining with a zinc alloy electrode resulted in a removal rate that was higher than that with a copper electrode of the same shape. To perform simultaneous machining of a microelectrode and microholes, a tandem structure mechanism was constructed. Continuous polygonal microhole machining was attained by applying the tandem EDM mechanism under the appropriate conditions. © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. Source


Hirayama A.,Tsukuba University of Technology | Okamoto T.,Iskra Industry Co. | Kimura S.,Tsukuba University of Technology | Nagano Y.,University of Tsukuba | And 4 more authors.
Journal of Clinical Biochemistry and Nutrition | Year: 2016

Kangen-karyu, a prescription containing six herbs, has been shown to achieve its pharmacological effect through oxidative stress-dependent pathways in animal models. The aim of this study is to investigate the relationship between the antioxidative effect and pharmacological mechanisms of Kangen-karyu, specifically its body temperature elevating effect in humans. Healthy human volunteers, age 35 ± 15 years old, were enrolled in this study. Surface body temperature, serum nitrite, reactive oxygen species (ROS) scavenging activities, and inflammatory cytokines were investigated before and 120 min after Kangen-karyu oral intake. Kangen-karyu significantly increased the surface-body temperature of the entire body; this effect was more remarkable in the upper body and continued for more than 120 min. Accompanying this therapeutic effect, serum nitrite levels were increased 120 min after oral administration. Serum ROS scavenging activities were enhanced against singlet oxygen and were concomitantly decreased against the alkoxyl radical. Serum nitrite levels and superoxide scavenging activities were positively correlated, suggesting that Kangen-karyu affects the O2 ·l--NO balance in vivo. Kangen-karyu had no effect on IL-6, TNF-α and adiponectin levels. These results indicate that the therapeutic effect of Kangenkaryu is achieved through NO- and ROS-dependent mechanisms. Further, this mechanism is not limited to ROS production, but includes ROS-ROS or ROS-NO interactions. © 2016 JCBN. Source


Sakajiri M.,Tsukuba University of Technology | Nakamura K.,Tokyo University of Science | Fukushima S.,Tokyo University of Science | Miyoshi S.,Tsukuba University of Technology | Ifukube T.,University of Tokyo
Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics | Year: 2012

It is difficult for the deafblind or the hearing impaired to control the pitch of their voice because they cannot perceive it. In particular, when singing, it is very difficult for them to control their voice pitch because they need to maintain a stable tone. We have developed a voice pitch control system to assist such people in their singing by means of a tactile display. Using this tactile feedback system, we verified in a previous study that two deafblind subjects were able to control the pitch of their voices with as much accuracy as hearing children. By using this tactile feedback system, the correspondence between musical scale and proprioceptive sensation (muscular sensation and so on) of the two subjects was returned to pre-hearing loss levels. They sung using not only tactile feedback but also proprioceptive feedback. In this paper, we investigate the effect of voice pitch training, without auditory feedback, using our tactile feedback display system. Eight hearing participants were examined under two conditions - "without tactile feedback" and "with tactile feedback" - to ascertain their abilities to control their pitch while subjected to masking noise. The results indicated the subjects could sing with more accurate pitch using only proprioceptive feedback after tactile feedback pitch control training than that of before tactile feedback one. © 2012 IEEE. Source


Yoshida R.,Tokyo University of Science | Adachi T.,Tokyo University of Science | Muratsu K.,Japan Society for the Promotion of Science | Muratsu K.,Kobe University | And 7 more authors.
CSEDU 2015 - 7th International Conference on Computer Supported Education, Proceedings | Year: 2015

In this paper, we propose and develop a full-body interaction system and simulation game called "Human SUGOROKU," which helps elementary school students learn about vegetation succeßion while having fun. We found that the students became more involved in the game because they were required to play it using their body movements. An experiment conducted with students verified that the participants became immersed in the virtual world of vegetation succeßion while playing Human SUGOROKU. This paper describes the structure of our game and the results of its evaluation. Source


Beuchat J.-L.,University of Tsukuba | Doi H.,Institute of Information Security | Fujita K.,FDK Module System Technology Corporation | Inomata A.,Nara Institute of Science and Technology | And 12 more authors.
Computers and Electrical Engineering | Year: 2010

Since their introduction in constructive cryptographic applications, pairings over (hyper)elliptic curves are at the heart of an ever increasing number of protocols. As they rely critically on efficient implementations of pairing primitives, the study of hardware accelerators has become an active research area. In this paper, we propose two coprocessors for the reduced ηT pairing introduced by Barreto et al. as an alternative means of computing the Tate pairing on supersingular elliptic curves. We prototyped our architectures on FPGAs. According to our place-and-route results, our coprocessors compare favorably with other solutions described in the open literature. We eventually present the first ASIC implementation of the reduced ηT pairing. © 2009 Elsevier Ltd. All rights reserved. Source


Tso R.,National Chengchi University | Yi X.,Victoria University | Yi X.,University of Tsukuba | Ito T.,Victoria University | And 3 more authors.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2010

This paper presents a new kind of (k,n)-threshold ring signature ((k,n)-ring signature) which is just a combination of k (1,n)-ring signatures. Our construction guarantees that a single signer can close at most one ring so the result of the combination is the required (k,n)-ring signature. This construction is useful in, for example, electronic negotiations or games where gradual revelation on how many people signed a given document is required. It also provides flexibility of the threshold k. The threshold-flexibility means that, in our scheme, we can change a (k,n)-ring signature into a (k′,n)-ring signature for any k′ ≤ n without revoking the original (k,n)-ring signature. This is useful for signers to withdraw their signatures afterward and/or is useful for new signers to add their (partial of the ring) signatures into the original ring signature. In addition, when k′ < k, this modification requires no extra computation. The security of the proposed scheme is proved in the random oracle model based on the hardness of the discrete logarithm problem and the intractability of inverting cryptographic one-way hash functions. © 2010 Springer-Verlag. Source


Onuma S.,Tokyo City University | Mochiki K.-I.,Tokyo City University | Adachi T.,High Energy Accelerator Research Organization | Muto R.,High Energy Accelerator Research Organization | And 7 more authors.
IPAC 2010 - 1st International Particle Accelerator Conference | Year: 2010

J-PARC (Japan Proton Accelerator Research Complex) is a new accelerator facility to produce MW class high power proton beams. In J-PARC main ring (MR) the proton beams is supplied hadron experimental facility by slow extraction to carry out various nuclear and particle physics experiments. A flat structure and small ripple noise are required for these beams to improve the efficiency of experiments and the availability of the accelerated beam. We are developing a spill control system to realize the requirement. The spill control system consists of extraction quadrupole magnets and a new feedback unit. From October 2009 we started spill feedback operation in J-PARC MR. Source


Tomizawa M.,High Energy Accelerator Research Organization | Adachi T.,High Energy Accelerator Research Organization | Ando A.,High Energy Accelerator Research Organization | Arakaki Y.,High Energy Accelerator Research Organization | And 23 more authors.
IPAC 2010 - 1st International Particle Accelerator Conference | Year: 2010

The proton beam from the J-PARC main ring is slowly extracted using a third integer resonance and delivered to the experimental hall for various nuclear and particle physics experiments. The slow extraction devices comprise two electro static septa, ten magnetic septa, four bump magnets, eight resonant sextupole magnets and their power supplies. We will report the extraction efficiency and spill structure obtained by the beam commissioning so far. We will also mention upgrade plans based on some ideas to aim at higher performance. Source


Okada R.,Tamagawa University | Nakagawa J.,Tamagawa University | Nakagawa J.,Tokyo Medical and Dental University | Takahashi M.,Tamagawa University | And 5 more authors.
Neuroscience Research | Year: 2015

The phonological abilities of congenitally deaf individuals are inferior to those of people who can hear. However, deaf individuals can acquire spoken languages by utilizing orthography and lip-reading. The present study used functional magnetic resonance imaging (fMRI) to show that deaf individuals utilize phonological representations via a mnemonic process. We compared the brain activation of deaf and hearing participants while they memorized serially visually presented Japanese kana letters (Kana), finger alphabets (Finger), and Arabic letters (Arabic). Hearing participants did not know which finger alphabets corresponded to which language sounds, whereas deaf participants did. All of the participants understood the correspondence between Kana and their language sounds. None of the participants knew the correspondence between Arabic and their language sounds, so this condition was used as a baseline. We found that the left superior temporal gyrus (STG) was activated by phonological representations in the deaf group when memorizing both Kana and Finger. Additionaly, the brain areas associated with phonological representations for Finger in the deaf group were the same as the areas for Kana in the hearing group. Overall, despite the fact that they are superior in visual information processing, deaf individuals utilize phonological rather than visual representations in visually presented verbal memory. © 2014. Source


Ryohei E.,Kobe University | Fusako K.,Tama Art University | Kumiko W.,Tama Art University | Hiroshi M.,Tokyo University of Science | And 2 more authors.
ACM International Conference Proceeding Series | Year: 2012

In this study, we examined the feature of the audience participation in the progress of the story in Puppet Theater. Puppet Theater is a puppet show system developed that is designed for appreciation by hearing-impaired children. Wada et al. (2012) conducted preliminary evaluation experiments performed with 52 healthy elementary school children who were surveyed using both questionnaires and interviews. The results indicated that audience participation in the progress of the story had the effect of encouraging the audience to think about the story. It was also confirmed that, through this participation, the audience is imbued with a sense of emotional investment in the characters, which stimulates audience into immersive participation in the story. © 2012 ACM. Source