The ' Universidad del Tolima ', is a faculty of higher education located in the Colombian city of Ibague capital of the department of Tolima, is a public autonomous institution departmental order created by Ordinance No. 005 of 1945, with legal, academic, administrative and financial autonomy and independent heritage that develops and manages its budget in accordance with the functions accordingly. In regard to policy and planning in the education sector is under the Ministry of National Education Colombia.It offers a wide range of academic, a modality has 23 undergraduate academic programs 3 technologies, 14 majors, 12 master's, one doctorate and distance mode offers 11 undergraduate degree programs, graduate 3, 4 technologies, 4 professional technicians, many of these programs are recognized for their high quality accreditation .The Universidad del Tolima has the Institute of Education.. Distance one of the largest and most important of Colombia because it has regional centers in the cities of Ibague, Bogotá , El Tunal, Kennedy Kennedy ), Medellin, Cali, Pereira, Neiva, Armenia, Popayán, Mocoa, Buenaventura , Girardot, Pitalito, El Espinal , Puerto Asis, Chaparral, Garzón , Campoalegre, Rivera , Algeciras Santander de Quilichao, Urabá, Villeta , Sibate, Fred and all municipalities in the department of TolimaIn the national rankings University of Tolima is one of the largest in the country and one of the students in academic and research best quality in the long list of public college’s remarkable career, and one of the top -level general. Wikipedia.
Cespedes-Rubio A.,University of Antioquia |
Cespedes-Rubio A.,University of Tolima |
Jurado F.W.,Autonomous University of Madrid |
Cardona-Gomez G.P.,University of Antioquia
Journal of Neuroscience Research | Year: 2010
Atorvastatin (ATV), a 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, exerts beneficial effects on stroke through several pleiotropic mechanisms. However, its role following cerebral ischemia is not completely understood yet. We evaluated the effect of ATV treatment on the synaptic adhesion proteins after a transient middle cerebral artery occlusion (t-MCAO) model in rats. Ischemic male Wistar rats were treated with 10 mg/kg ATV. The first dose was 6 hr after reperfusion, then every 24 hr for 3days. Our findings showed that ATV treatment produced an increase in pAkt ser473 and a decrease in pMAPK 44/42 protein levels 12 and 24 hr postischemia in the cerebral cortex and the hippocampus. However, p120 catenin and αN-catenin became drastically increased throughout the temporal course of postischemia treatment (12-72 hr), mainly in the hippocampus. Neurological recovery was observed at 48 and 72 hr, supported by a significant reduction of infarct volume, neuronal loss, and glial hyperreactivity after 72 hr of postischemia treatment with ATV. ATV treatment also up-regulated the association of p120ctn, αN-catenin to PSD-95, accompanied by a reduction of RhoA activation and the recovery of MAP2 immunoreactivity, these being significantly affected by the focal cerebral ischemia. Our findings suggested that p120ctn and αN-catenin synaptic adhesion proteins are crucial molecular targets in ATV-mediated neuroprotection and neuronal plasticity after focal cerebral ischemia. © 2010 Wiley-Liss, Inc.
Francel A.,University of Tolima
Urbe | Year: 2017
Ibagué is a Colombian medium-sized city in which the center is a commercially vibrant and socially depressed area. To solve their problems a proposal of urban redesign within the framework of national partial plans was made eventually incorporated into the planning principles the Ministry of Housing in 2012. However, the plan has not been implemented, as it has a condition of ideality and probability, common to urban planning since 1935. To understand the similarities and differences between these plans and the urban reality, a sector analysis was performed using the historic-artistic method in its object-based component adjusted for analyzing morphologies. The map overlay for identifying trends evidence the continued ignorance of the historical dynamics and miscalculation in planning processes. This research provides analysis criteria that can help incorporating historical morphological studies in order to make planning decisions in similar sectors and in cities that have overlaps between national policies and municipal development as a cause of conflicts.
Barbosa O.,University of Tolima |
Ortiz C.,Industrial University of Santander |
Berenguer-Murcia A.,University of Alicante |
Torres R.,Ecopetrol SA |
And 2 more authors.
Biotechnology Advances | Year: 2015
In this review, we detail the efforts performed to couple the purification and the immobilization of industrial enzymes in a single step. The use of antibodies, the development of specific domains with affinity for some specific supports will be revised. Moreover, we will discuss the use of domains that increase the affinity for standard matrices (ionic exchangers, silicates). We will show how the control of the immobilization conditions may convert some unspecific supports in largely specific ones. The development of tailor-made heterofunctional supports as a tool to immobilize-stabilize-purify some proteins will be discussed in deep, using low concentration of adsorbent groups and a dense layer of groups able to give an intense multipoint covalent attachment. The final coupling of mutagenesis and tailor made supports will be the last part of the review. © 2015 Elsevier Inc.
Calderon G.,Autonomous University of Coahuila |
Munoz J.H.,University of Tolima |
Vera C.E.,University of Tolima
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013
Axial-vector mesons a1(1260), f1(1285), h 1(1170), K1(1270), and K1(1400) can be produced in semileptonic τ→APντ decays, where P stands for the pseudoscalar mesons π or K. We calculate the branching ratios based in a meson dominance model. The exclusive channels τ-→a 1(1260)-π0ν, τ-→a 1(1260)0π-ν, and τ-→h 1(1170)π-ν turn out to be of order O(10 -3), the channel τ-→f1(1285)π -ν of order O(10-4), and channels τ -→K1(1270)-π0ν, τ -→K1(1270)0π-ν, τ -→K1(1400)-π0ν, and τ-→K1(1400)0π-ν of order O(10-6). These results indicate that the branching ratios could be measured in experiments. © 2013 American Physical Society.
Falguera V.,University of Lleida |
Quintero J.P.,University of Tolima |
Jimenez A.,Universidad Politécnica de Ingeniería |
Munoz J.A.,University of Tolima |
Ibarz A.,University of Lleida
Trends in Food Science and Technology | Year: 2011
Edible films and coatings are thin layers of edible materials applied on food products that play an important role on their conservation, distribution and marketing. Some of their functions are to protect the product from mechanical damage, physical, chemical and microbiological activities. Their use in food applications and especially highly perishable products such as horticultural ones, is based on some particular properties such as cost, availability, functional attributes, mechanical properties (flexibility, tension), optical properties (brightness and opacity), the barrier effect against gases flow, structural resistance to water and microorganisms and sensory acceptability. In this piece of work, the lastest advances on their composition (polymers to be used in the structural matrix), including nanoparticles addition, and properties have been reviewed, as well as the trends in the research about their different applications, including oil consumption reduction in deep-fat fried products, their use in combination with bioactive compounds that bring foodstuff additional functions and shelf life extension of highly perishable products. © 2011 Elsevier Ltd.
Barrios M.,University of Tolima |
Frances F.,Polytechnic University of Valencia
Hydrological Processes | Year: 2012
Nonlinear dynamics and spatial variability in hydrological systems make the formulation of scaling theories difficult. Therefore, the development of knowledge related to scale effects, scaling techniques, parameterization and linkages of parameters across scales is highly relevant. The main purpose of this work is to analyse the spatial effect of the static storage capacity parameter H u and the saturated hydraulic conductivity parameter k s from microscale (sub-grid level) to mesoscale (grid level) and its implication to the definition of an optimum cell size. These two parameters describe the upper soil water characteristics in the infiltration process conceptualization of the TETIS hydrological model. At microscale, the spatial heterogeneity of H u and k s was obtained generating random parameter fields through probability distribution functions and a spatial dependence model with pre-established correlation lengths. The effective parameters at mesoscale were calculated by solving the inverse problem for each parameter field. Results indicate that the adopted inverse formulation allows transferring the nonlinearity of the system from microscale to the mesoscale via non-stationary effective parameters. Their values at each cell and time step are in the range of zero to the mean value of the parameter at microscale. The stochastic simulations showed that the variance of the estimated effective parameters decreases when the ratio between mesoscale cell size and correlation length at microscale increases. For a ratio greater than 1, we found cell sizes having the characteristics of a representative elementary area (REA); in such case, the microscale variability pattern did not affect the system response at mesoscale. © 2011 John Wiley & Sons, Ltd.
Moya R.,Costa Rica Institute of Technology |
Marin J.D.,University of Tolima
New Forests | Year: 2011
Commercial Tectona grandis plantations using clones have attracted considerable interest for lumber production in tropical regions where small areas are frequent. However, studies on wood properties are limited. Therefore, the purpose of this study is to group clones with similar wood color characteristics using the CIELab system, and mechanical resistance by dynamic stiffness (Ed) in order to obtain different types of clones for different climate and edaphic conditions. It was found that lightness (L*), yellowness (b*), redness (a*), and Ed are similar to those found for other plantation trees. These wood characteristics are significantly influenced by clone and site. Variance due to clone and site went from 31 to 53% and from 2.95 to 24.22%, respectively. Another source of variance was distance from pith, with the exception of parameter b*, which was not affected. Finally, clones were grouped (using multivariate analysis) according to color and mechanical resistance. This analysis established 4 groups by color and 5 groups by Ed. Clone clustering will allow us to choose or use clones with similar wood properties according to site and environmental conditions increasing area production and wood quality uniformity. © 2011 Springer Science+Business Media B.V.
Canal N.A.,University of Tolima
Zootaxa | Year: 2010
Anastrepha is the most diverse and economically important genus of Tephritidae in the American tropics and many species remain undescribed. Three new species A. acuminata, A. carreroi and A. sinuosa collected from Colombia are described in this paper and six species: A.isolata, A. perdita, A. sororcula, A. montei, A. panamensis and A. lanceola are reported from Colombia for the first time. The Colombian species of Anastrepha are discussed. Copyright © 2010 Magnolia Press.
Carvajal-Carmona L.G.,University of Oxford |
Carvajal-Carmona L.G.,University of Tolima
Current Opinion in Genetics and Development | Year: 2010
The case for identifying rare, disease-associated germline variants rather than undertaking larger genome-wide association (GWA) studies for common variants is increasingly being advocated. I agree with the importance of identifying rare variation in human disease, but believe more thought needs to be put into the limitations of such enterprises before advocating a dramatic departure from the GWA approach. In this paper, I discuss some of the main challenges in identifying rare disease variants with modest effects in disease, including: the overoptimistic expectations about their effects; the need for very large studies needed to prove, beyond doubt, statistical associations; the problems associated with private variants, including the need for functional studies; the difficulties in prioritisation of candidates for further validation and the issues related to the accurate estimation of the risk associated with individual rare variants. The rare variant approach is very promising, but it remains largely untested in comparison with the proven and successful GWA approach. Both strategies must continue to be pursued in parallel and their advantages and pitfalls must be considered without excessive scepticism or expectation. © 2010 Elsevier Ltd.
Agency: European Commission | Branch: FP7 | Program: CP-SICA | Phase: HEALTH-2007-2.4.1-14 | Award Amount: 3.96M | Year: 2009
Colorectal cancer (CRC) is common in both sexes, has relatively poor outcome and has no major avoidable risk factor. Recent studies have shown that common inherited single nucleotide polymorphisms (SNPs) can increase cancer risk. We have shown CRC risk to be associated with SNPs on chromosomes 8q24.21, 15q14 and 8q21. These variants account for <5% of the genetic risk of CRC, but will be very important when their effects are added to those of other, as-yet undetected CRC SNPs. A few genome-wide association studies (GWASs) based on populations of European descent are trying to identify the remaining common CRC genes. Evidence suggests that these studies will not be large enough on their own to detect all CRC SNPs, as: relative risks associated with most SNPs are modest; some disease alleles are rare, at least in Europe; and many variants may lie outside conventional gene boundaries or haplotype blocks. The admixed LA population provides an exciting opportunity to identify new CRC genes that are more tractable to detection in LA, or have been missed by chance in European studies. We shall undertake a combined GWAS and admixture mapping study for CRC predisposition genes in 6,000 LA cases and 6,000 controls. We shall test the disease-associated variants in 3,500 cases and 3,500 controls from Europe. We aim primarily to detect SNPs with effects in both LA and Europe, but also SNPs with effects specific to LA. Eventually, we aim to develop a polymorphism panel for predicting the risk of CRC in the general population, so that those at increased risk can be offered effective measures to prevent cancer. CRC is increasing in frequency in LA and prognosis is poorer than in Europe. We shall use our project as a focus for education about CRC, especially in LA. The study will also provide training for young LA researchers. Our work will provide a direct benefit to medical science and the populations of LA and Europe.