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Bristol, United Kingdom

The University of the West of England is a university located near the city of Bristol, United Kingdom. Its main campus is at Frenchay near Bristol, about five miles north of the city centre and close to the M32 motorway.UWE also has campuses at Glenside in north-east Bristol and Bower Ashton, near Ashton Court in south-west Bristol. There is also a regional centre at Gloucester Docks, Gloucestershire, and an associate faculty specialising in animal behaviour and welfare, agricultural and sports related courses in Hartpury, Gloucestershire.With around 27,000 students and 3,000 staff, UWE is the larger of the two universities in Bristol The university did not rank in the top 800 universities in the QS World University Rankings.The Chancellor of UWE is Sir Ian Carruthers and Steven West is the Vice-Chancellor. Wikipedia.

Adamatzky A.,University of the West of England
Organic Electronics: physics, materials, applications | Year: 2013

Acellular slime mould Physarum polycephalum is a popular now user-friendly living substrate for designing of future and emergent sensing and computing devices. P. polycephalum exhibits regular patterns of oscillations of its surface electrical potential. The oscillation patterns are changed when the slime mould is subjected to mechanical, chemical, electrical or optical stimuli. We evaluate feasibility of slime-mould based colour sensors by illuminating Physarum with red, green, blue and white colours and analysing patterns of the slime mould's electrical potential oscillations. We define that the slime mould recognises a colour if it reacts to illumination with the colour by a unique changes in amplitude and periods of oscillatory activity. In laboratory experiments we found that the slime mould recognises red and blue colour. The slime mould does not differentiate between green and white colours. The slime mould also recognises when red colour is switched off. We also map colours to diversity of the oscillations: illumination with a white colour increases diversity of amplitudes and periods of oscillations, other colours studied increase diversity either of amplitude or period. © 2013 Elsevier B.V. All rights reserved. Source

Ladomery M.,University of the West of England
International Journal of Cell Biology | Year: 2013

The vast majority of human genes are alternatively spliced. Not surprisingly, aberrant alternative splicing is increasingly linked to cancer. Splice isoforms often encode proteins that have distinct and even antagonistic properties. The abnormal expression of splice factors and splice factor kinases in cancer changes the alternative splicing of critically important pre-mRNAs. Aberrant alternative splicing should be added to the growing list of cancer hallmarks. © 2013 Michael Ladomery. Source

Adamatzky A.,University of the West of England
Sensors and Actuators, B: Chemical | Year: 2013

Slime mould Physarum polycephalum is a single cells visible by unaided eye. The cells shows a wide spectrum of intelligent behaviour. By interpreting the behaviour in terms of computation one can make a slime mould based computing device. The Physarum computers are capable to solve a range of tasks of computational geometry, optimisation and logic. Physarum computers designed so far lack of localised inputs. Commonly used inputs - illumination and chemo-attractants and -repellents - usually act on extended domains of the slime mould's body. Aiming to design massive-parallel tactile inputs for slime mould computers we analyse a temporal dynamic of P. polycephalum's electrical response to tactile stimulation. In experimental laboratory studies we discover how the Physarum responds to application and removal of a local mechanical pressure with electrical potential impulses and changes in its electrical potential oscillation patterns. © 2013 Elsevier B.V. Source

The separation of a mixture of neutral, strongly acidic and strongly basic compounds was studied in hydrophilic interaction chromatography using a bare silica phase, and bonded silica phases with diol, zwitterionic, amide and hydrophilic/hydrophobic groups. The mobile phase was acetonitrile-ammonium formate buffer at low pH. Differences in selectivity between these various columns indicate that the stationary phase cannot function merely as an inert support for a water layer into which the solutes partition from the bulk mobile phase. Attempts to fit the retention data to equations which describe either partition or adsorption mechanisms were inconclusive. Ion exchange was a significant contributor to the retention of ionised bases on all columns studied. Van Deemter plots indicated that the efficiency as a function of flow rate varied between the columns, which might be attributable in part to the presence of either monomeric or polymeric bonded phase layers. © 2010 Elsevier B.V. Source

Fused core or superficially porous columns offer the advantages of higher efficiency compared with totally porous columns of the same particle size, but similar operating pressures. However, their performance may be adversely affected by extra-column effects that become more significant as the column efficiency increases, and as the diameter of the column is reduced. In this study, we show that 10 cm × 0.46 cm fused-core columns can be used on modified conventional instruments (" microbore systems" ) without serious loss in performance, and this approach is at present likely to yield superior results compared with use of 0.21. cm columns (of identical efficiency) on current UHPLC instruments that have minimised extra-column volume. Furthermore, the true efficiency of commercial narrow-bore fused-core columns appears to be reduced compared with those of conventional bore, which may be due to packing difficulties for the former type. The fused-core columns in general gave excellent performance, showing no evidence of an upturn in the Knox plots at high flow velocities and elevated temperatures. Careful control of experimental conditions is necessary to ensure accurate data for these plots. © 2010 Elsevier B.V. Source

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