Philadelphia, PA, United States

University of the Sciences in Philadelphia
Philadelphia, PA, United States

The University of the science , officially known as the University of the science in Philadelphia, is a university in the Spruce Hill neighborhood of Philadelphia. Uscience offers bachelor's, master's, and doctoral degrees in pharmacy and a variety of other health-related disciplines. Wikipedia.

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University of the Sciences in Philadelphia and Wayne State University | Date: 2017-01-09

An ionizing system includes a channel and a heater coupled to the channel. The channel has an inlet disposed in a first pressure region having a first pressure and an outlet disposed in a second pressure region having a second pressure. The first pressure is greater than the second pressure. The heater is for heating the channel, and the channel is configured to generate charged particles of a sample in response to the sample being introduced into the channel.

Pearce M.M.,University of the Sciences in Philadelphia
Current Opinion in Genetics and Development | Year: 2017

A key pathological hallmark of most neurodegenerative diseases is the misfolding of a particular protein, leading to deposition of toxic protein aggregates in brain tissue. Recent data provide compelling evidence that pathogenic protein aggregates have prion-like properties—they self-replicate by templated misfolding of monomeric proteins and spread between individual cells. Studies in genetic model organisms have expanded our understanding of how prion-like pathogenic aggregates propagate in vivo, revealing potential roles for spreading along neural networks and key cellular processes in both neurons and glial cells. These findings and future studies in genetic models will help guide the development of novel therapeutic strategies that directly target the molecular mechanisms underlying these devastating diseases. © 2017 Elsevier Ltd

Stefanacci R.G.,University of the Sciences in Philadelphia
The American journal of managed care | Year: 2011

Every 69 seconds, a person in the United States develops Alzheimer's disease (AD). By 2050, this rate is expected to double. Total direct costs of AD and dementia (AD/D) are estimated at $183 billion, and are expected to increase to $1.1 trillion by 2050. In 2010, unpaid care was valued at an estimated $202 billion. Caregivers of patients with AD are usually family members, and provide up to 70 hours of care per week. By delaying institutionalization of an AD patient, a savings of $2029 per month in direct healthcare costs could be realized; therefore, caregiver support is a significant factor in controlling costs. It is important for those with AD/D to have prescription plans that optimize access to AD/D therapies. Among older adults who previously did not have prescription coverage, 80% are now enrolled in Medicare Part D. Three preferred AD/D agents (donepezil, extended release galantamine hydrochloride, and memantine hydrochloride) have been identified by an expert panel. It is important, given the clinical course of AD, especially with progression to moderate-to-severe disease, that physicians continue to have access to preferred medications as demonstrated through evidence-based clinical evaluations. Many Medicare Part D beneficiaries are subject to a gap in prescription coverage known as the "donut hole," including 64% of patients with AD. Because of the increased out-of-pocket expenditures associated with this coverage gap, some patients stop taking their medication completely or reduce medication use. It is critical to avoid lapses in maintenance therapy, as functional and cognitive abilities cannot be regained. Numerous clinical trials have demonstrated the pharmacoeconomic benefits of appropriate and preferred AD therapies; greater therapeutic availability may lead to better adherence and therefore improved outcomes.

University of the Sciences in Philadelphia | Date: 2013-12-03

The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (iPSCs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells. More specifically, the exemplary methods disclosed herein can be used for creating induced pluripotent stem cells from various mammalian cell types, including human fibroblasts. Exemplary methods of feeder-free derivation of human induced pluripotent stem cells using synthetic messenger RNA are also disclosed.

Agency: NSF | Branch: Continuing grant | Program: | Phase: Macromolec/Supramolec/Nano | Award Amount: 459.00K | Year: 2011

With the support of this award from the Macromolecular, Supramolecular, and Nanochemistry (MSN) program of the Chemistry Division, Dr. Vojislava Pophristic and Dr. Guillermo Moyna, of the Department of Chemistry and Biochemistry at the University of Sciences in Philadelphia (USP), and Dr. Alexey Teslja, of the Department of Chemistry and Pharmaceutical Science at the Fairleigh Dickinson University (FDU), will develop an approach to enhance rational design of foldamers. Foldamers are synthetic oligomers that adopt defined, stable secondary structures in solution, and have many realized and potential applications in a number of different scientific areas. The main objective of this proposal is to establish information transferability between the foldamer building blocks and the final foldamer structure. The research will focus on an important class of foldamers, the arylamide class, which features a backbone with a [-(aromatic ring-peptide unit)n-] pattern whose conformational preference significantly depends on specific nature and location of aromatic ring substituents, as well as the environment. Utilizing a combination of computational chemistry methods, synthesis, NMR and IR spectroscopy, the researchers will study the conformation and energetics of dimer to dodecamer units of the arylamide class in various solvents. The effort will lead to building a databank with the ultimate goal of rapid and accurate prediction of arylamide foldamer conformations. The research will also generate appropriate force field parameters and outline a general strategy to enhance rational design of foldamers.

The potential impact of this research is in an increased ability to model, and thus design new foldamers, with novel applications. The results and data will be made available through peer reviewed publications and presentations at scientific meetings, as well as through a publicly accessible databank. Based on the general nature of the information to be provided by the proposed research, as well as its applicability to foldamer specific research, it is expected that both the broad scientific community, e.g. chemists, biochemists, and material scientists, as well as researchers working on specific foldamer topics, will benefit from this research very positively. The outreach plans of this project involve FDU, a non-Ph.D. granting institution, to promote and facilitate development of their research program in chemistry. Undergraduate and graduate students at both USP and FDU will be trained on a number of skill sets including computational chemistry, synthesis, NMR and IR spectroscopy, as well as on how to use them together efficiently.

Agency: NSF | Branch: Continuing grant | Program: | Phase: CONDENSED MATTER PHYSICS | Award Amount: 66.93K | Year: 2015

This project will investigate sub-structure in the superconducting energy gap of very clean samples of multi-gapped superconductors such as magnesium diboride (MgB2) and some iron-based superconductors. The energy gap is a key feature in the study of these novel materials and the results of these experiments can help validate existing theories, provide new data, and contribute to a better understanding of the role of gap distribution in multi-gapped superconductivity. Experiments will involve high-resolution tunneling spectroscopy made possible by cooling samples to low to very low (sub-Kelvin) temperatures and using high-resolution techniques of data acquisition. Samples will consist of thin film Josephson junctions to be obtained from several collaborators who are world leaders in the fabrication of high-quality samples. This research will be carried out at a primarily undergraduate institution, where undergraduate research is rapidly growing. This project will support the training of undergraduate and pre-college students and open physics research opportunities for women and minorities in a liberal arts environment where majority of students are women.

This project supports the experimental study of superconductors in a primarily undergraduate institution. The energy gap of a superconductor is an important property that enables us to better understand and apply these novel materials. While many superconductors have only a single energy gap, this research will probe, to very high resolution, the energy gap of multi-gapped superconductors such as magnesium diboride and some of the recently-discovered iron-based superconductors. This will be made possible by using very clean thin film Josephson junctions obtained from research collaborators who are world leaders in the fabrication of high-quality samples. The samples will be cooled to temperatures close to absolute zero and probed using tunneling spectroscopy and high-resolution data acquisition techniques. The results will help validate existing theories and provide new data to better understand multi-gapped superconductivity. This project supports the education and training of undergraduates in solid-state physics in a liberal arts setting where sixty-four percent of students are women. Undergraduates will receive training in low-noise electronics, cryogenics, and materials characterization skills needed for graduate studies or work in physics and many STEM fields. Furthermore, the educational component of this research makes possible a three-day summer science camp for middle school girls. The camp is designed to enhance the interest in science through interactive experiments and demonstrations of real-world physics, role-playing activities, laboratory tours, and other hands-on activities.

Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 345.00K | Year: 2011

With support from the Chemical Measurement and Imaging Program, Professor Charles N. McEwen of the University of the Sciences seeks improved understanding of certain newly developed mass spectrometric (MS) ionization methods, with aims of improving reproducibility and sensitivity. These ionization methods (discovered in collaboration with Professor Sarah Trimpin of Wayne State University) have attributes of both matrix assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI). They each produce multiply charged ions, similar to ESI, allowing analysis of high mass compounds and enhancing utility of ion mobility techniques. Increasing the sensitivity and reproducibility of these new ionization methods may make possible high spatial resolution imaging under atmospheric conditions.

Areas requiring high throughput analyses (such as consumer protection, counter-terrorism, environmental monitoring, clinical applications, and biological materials analysis) will be impacted by these developments. The broad training gained by the graduate and undergraduate students involved will enhance their future scientific potential.

Agency: NSF | Branch: Standard Grant | Program: | Phase: OFFICE OF MULTIDISCIPLINARY AC | Award Amount: 175.00K | Year: 2012

With this award from the Major Research Instrumentation Program, Professor Preston Moore from University of the Sciences in Philadelphia and colleagues Michael Bruist, Randy Zauhar, Vojislava Pophristic and Zhijun Li will acquire a high performance CPU-GPU computer cluster. The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) coarse grain molecular dynamics models to investigate complex interfacial systems such as solid/liquid interface and protein/lipid systems; (b) methodology and parameters for the prediction of arylamide foldamer structure to aid the design of foldamers; (c) molecular database and web accessible interface for computer aided drug design (CADD); (d) homology modeling of membrane proteins with low sequence identity; and (e) noncanonical base pairs in RNA loops and the role of conformational changes in protein-DNA complexes.

Computer systems and clusters of computers are used by chemists and biochemists to investigate reactions and the properties of chemicals and materials using theoretical models and programs. The computer calculations are used, often along with experimental data, to model and better understand many types of complex chemical and biological phenomena. They are also used to predict results and guide experiments. This resource will be used in research and in course work by undergraduate and graduate students as well as faculty training them in computational chemistry methodology with a modern computer system. Collaborations with local industries such as Y-Carbon will enhance the manufacturing of nanomaterials by design, which is essential to improving the U.S. manufacturing base of advanced materials. In addition, outreach programs for Philadelphia high schools and the community, which is predominately composed of underrepresented groups, will also use the cluster.

University of the Sciences in Philadelphia | Date: 2015-11-20

The present invention relates to compositions useful in inhibiting Bcl-XL or MCL-1 and disrupting p53-MDM2 and p53-MDMX interactions, and methods of using those compositions for treating a subject for conditions responsive to increasing p53 mediated activity or promoting p53 independent apoptosis, such as treating cancer. In some aspects, the compositions of this invention relate to fusion polypeptides comprising a human serum polypeptide and a p53-peptide, which can be, in some aspects, a p53 derived peptide and/or a p53 activating peptide.

University of the Sciences in Philadelphia | Date: 2013-01-24

An ion source able to ionize liquid and gaseous effluents from interfaced liquid or gaseous separation techniques and from direct introduction of the analyte to the entrance of the ionization region. The liquid effluents from sources such as a liquid chromatograph are ionized by inlet ionization methods and the gaseous effluents from sources such as a gas chromatograph are ionized by a corona or Townsend electrical discharge, or an alpha or beta emitter, or by inlet ionization, or by photoionization. Ionization occurs in an intermediate pressure region linking atmospheric pressure and the vacuum of the mass analyzer. The source has the ability to ionize compounds from both liquid and gaseous sources, which facilitates ionization of volatile compounds separated by gas chromatography, volatile or non-volatile compounds separated by liquid chromatography, or infused into the ionization. The ionization methods can be achieved with a single configuration or with separately optimized configurations.

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