University of the Region of Joinville
Sao Paulo, Brazil
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Hader D.-P.,Friedrich - Alexander - University, Erlangen - Nuremberg | Erzinger G.S.,University of the Region of Joinville
Chemosphere | Year: 2017

The microcrustacean Daphnia is sensitive to many toxic substances and can be cultured easily. The Daphniatox instrument is based on computerized image analysis tracking swimming organisms in real time. The software evaluates 14 endpoints including motility, swimming velocity, orientation with respect to light and gravity as well as cell form and size. The system determines movement vectors of a large number of organisms to warrant high statistical significance and calculates mean values as well as standard deviation. Tests with K dichromate show that the toxin inhibits motility (EC50 0.75 mg/L), swimming velocity (EC50 0.70 mg/L) and even causes a significant decrease in length (16% at 4 mg/L) and changes the form of the animals, This bioassay can be used to monitor the toxicity of a large number of dissolved pollutants and toxic substances such as arsenic, dichromate and persistent organic pollutants. © 2016 Elsevier Ltd

Plastic responses in plants can be induced by spatial heterogeneity, being the restinga a supportive ecosystem to understand these responses due to its limiting environmental conditions. This study evaluated so compared the leaf plastic responses in two populations of Tibouchina clavata (Melastomataceae) inhabiting the herbaceous and forest formations of the restinga Acaraí State Park, located in São Francisco do Sul-SC. In the ten individuals sample of each formation were measured leaf morphoanatomic attributes and stem. Environmental variables such as edaphic nutrition, gravimetric moisture and light radiation were measured. Mean values for each variable were compared by the Student t test. For each attribute, it was calculated phenotypic plasticity index. Morphological and anatomical attributes differentiate the two populations together, and the population of herbaceous formation typically xeromorphic due to more stringent environmental conditions. More favorable terms given by the increased supply of nutrients and water in the forest environment provided greater investment of growing individuals. Anatomical attributes were shown little plastic when compared to the morphological. T. clavata it proved to be a morphologically plastic kind that allows the understanding of the effects of the limiting factors of the restinga on plant development, with emphasis on nutrition, water and luminous conditions that induce xeromorphism.

Aptroot A.,ABL Herbarium | Gumboski E.L.,University of the Region of Joinville | Caceres M.E.D.S.,Federal University of Sergipe
Cryptogamie, Mycologie | Year: 2017

The following new species of Arthoniales are described, from Santa Catarina state in South Brazil: Herpothallon tricolor, Neosergipea bicolor, and Opegrapha xanthonica. In addition, 92 species are reported new to Santa Catarina state, 15 of which are new to Brazil, mostly species that are widespread in temperate regions on the northern hemisphere. © 2017 Adac. Tous droits réservés.

Da Silva L.A.L.,University of the Region of Joinville | Pezzini B.R.,University of the Region of Joinville | Soares L.,University of the Region of Joinville
Pharmacognosy Magazine | Year: 2015

Background: The chemical characterization is essential to validate the pharmaceutical use of vegetable raw materials. Ultraviolet spectroscopy is an important technique to determine flavonoids, which are important active compounds from Ocimum basilicum. Objective: The objective of this work was to optimize a spectrophotometric method, based on flavonoid-aluminum chloride (AlCl3 ) complexation to determine the total flavonoid content (TFC) in leaves of O. basilicum (herbal material), using response surface methodology. Materials and Methods: The effects of (1) the herbal material: Solvent ratio (0.02, 0.03, 0.05, 0.07, and 0.08 g/mL), (2) stock solution volume (0.8, 2.3, 4.4, 6.5, and 8.0 mL) and (3) AlCl3 volume (0.8, 1.0, 1.2, 1.4, and 1.6 mL) on the TFC were evaluated. The analytical performance parameters precision, linearity and robustness of the method were tested. Results: The herbal material: Solvent ratio and stock solution volume showed an important influence on the method response. After choosing the optimized conditions, the method exhibited a precision (RSD%) lower than 6% for repeatability (RSD%) and lower than 8% for intermediate precision (on the order of literature values for biotechnological methods), coefficient of correlation of 0.9984, and no important influence could be observed for variations of the time of complexation with AlCl3. However, the time and temperature of extraction were critical for TFC method and must be carefully controlled during the analysis. Conclusion: Thus, this study allowed the optimization of a simple, fast and precise method for the determination of the TFC in leaves of O. basilicum, which can be used to support the quality assessment of this herbal material.

de Oliveira E.L.,Hans Dieter Schmidt Regional Hospital | Westphal G.A.,Municipal Sao Jose Municipal Hospital | Mastroeni M.F.,University of the Region of Joinville
Brazilian Journal of Cardiovascular Surgery | Year: 2012

Objective: To describe the demographic and clinical characteristics of patients undergoing coronary artery bypass graft surgery (CABG) and to test their relation to mortality. Methods: This study was a retrospective medical record review of 655 consecutive patients undergoing CABG from May 2002 to April 2010. Results: Of the 655 patients, 12.1% died during the hospital stay. Mortality was significantly (p<0.05) higher in females (17.3%), aged < 70 years (22.8%), in emergency surgery (36.4%), in cases of readmission to the intensive care unit (ICU) (33.3%), when the stay in the ICU was < three days (16.3%), undergoing longer cardiopulmonary bypass (CPB), and with more comorbidities (15.4%). Predictor variables of death identified with logistical regression analysis were: female (OR=2.04), age > 70 years (OR=2.69), emergency surgery (OR=15.43) and urgency (OR=3.81), performance of CPB (OR=2.19) and readmission to the ICU (OR=4.33). Conclusion: Variables such as female sex, increased age, type of surgery, readmission to the ICU, ICU stay, comorbidities, and duration of CPB influence the outcome death in patients undergoing CABG. Thus, such aspects should be considered to reduce hospital mortality in patients undergoing such surgery.

Fernandes E.R.K.,University of the Region of Joinville | Marangoni C.,University of the Region of Joinville | Souza O.,University of the Region of Joinville | Sellin N.,University of the Region of Joinville
Energy Conversion and Management | Year: 2013

Wet and semi-dried banana leaves were characterized through elemental and proximate analyses, lignocellulosic fraction and thermogravimetric analysis (TG/DTG), differential scanning calorimetry (DSC) and high heating value analysis to assess their use as biomass in generating energy through combustion; they were also assessed to determine the potential of obtaining value-added products through pyrolysis. The wet banana leaves had high moisture content of 74.7%. The semi-dried samples exhibited 8.3% moisture, 78.8% volatile solids, 43.5% carbon and a higher heating value of 19.8 MJ/kg. The nitrogen and sulfur contents in the banana leaves were very low. The semi-dried and wet leaves had hemicellulose and lignin contents close to other biomass fuels, and the semi-dried leaves had the lowest cellulose content, of 26.7%. The wet and semi-dried samples showed the same thermal events in oxidizing and inert atmospheres, but with distinctly different mass loss and energy release intensities. The chemical characteristics and the thermal behavior demonstrated by the semi-dried samples indicate their potential for use as biomass, with results similar to other agro-industrial wastes currently used. © 2013 Elsevier Ltd. All rights reserved.

Romao L.M.,University of the Region of Joinville | Nievola J.C.,Pontifical Catholic University of Parana
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2012

The Gene Ontology (GO) project is a major bioinformatics initiative with the aim of standardizing the representation of gene and gene product attributes across species and databases. The classes in GO are hierarchically structured in the form of a directed acyclic graph (DAG), what makes its prediction more complex. This work proposes an adapted Learning Classifier Systems (LCS) in order to predict protein functions described in the GO format. Hence, the proposed approach, called HLCS (Hierarchical Learning Classifier System) builds a global classifier to predict all classes in the application domain and its is expressed as a set of IF-THEN classification rules, which have the advantage of representing more comprehensible knowledge. The HLCS is evaluated in four different ion-channel data sets structured in GO terms and compared with a Ant Colony Optimisation algorithm, named hAnt- Miner. In the tests realized the HLCS outperformed the hAnt-Miner in two out of four data sets. © Springer-Verlag Berlin Heidelberg 2012.

Ferrari F.,University of the Region of Joinville | Reis M.A.M.,University of the Region of Joinville
World Journal of Gastroenterology | Year: 2013

Aim: To study the association between the incidence of gastric cancer and populational exposure to risk/protective factors through an analysis of international databases. Methods: Open-access global databases concerning the incidence of gastric cancer and its risk/protective factors were identified through an extensive search on the Web. As its distribution was neither normal nor symmetric, the cancer incidence of each country was categorized according to ranges of percentile distribution. The association of each risk/protective factor with exposure was measured between the extreme ranges of the incidence of gastric cancer (under the 25th percentile and above the 75th percentile) by the use of the Mann-Whitney test, considering a significance level of 0.05. Results: A variable amount of data omission was observed among all of the factors under study. A weak or nonexistent correlation between the incidence of gastric cancer and the study variables was shown by a visual analysis of scatterplot dispersion. In contrast, an analysis of categorized incidence revealed that the countries with the highest human development index (HDI) values had the highest rates of obesity in males and the highest consumption of alcohol, tobacco, fruits, vegetables and meat, which were associated with higher incidences of gastric cancer. There was no significant difference for the risk factors of obesity in females and fish consumption. Conclusion: Higher HDI values, coupled with a higher prevalence of male obesity and a higher per capita consumption of alcohol, tobacco, fruits, vegetables and meat, are associated with a higher incidence of gastric cancer based on an analysis of populational global data. © 2013 Baishideng Publishing Group Co., Limited. All rights reserved.

The association between attention deficit and hyperactivity disorder (ADHD) and epilepsy can cause significant impact on the social life of affected individuals and their families. Clinical studies suggest that 30-40% of people with epilepsy also have ADHD. There are no studies which demonstrate that short or long-term treatment with methylphenidate increases the risk of seizures. Some studies attempt to relate drug interactions between methylphenidate and antiepileptic drugs, but adverse effects of methylphenidate have not been shown clearly. This review presents some neurobiological and physiopathogenic aspects, common to ADHD and epilepsy, from recent research studies, related to pharmacology, neuroimaging and electroencephalography. Possible risk of occurrence of seizures associated with the use of methylphenidate are also discussed.

Gumboski E.L.,University of the Region of Joinville
Lichenologist | Year: 2015

Calopadia saxicola is described as new to science. The species grows on rocky shores in southern Brazil and is characterized by the corticate thallus, pruinose apothecia with brownish to reddish brown disc, mainly 2-3-spored asci with muriform ascospores, and the absence of secondary metabolites. A description with ecological data, figures, comments and a key to all species in the genus known from Brazil are given. © 2015 British Lichen Society.

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