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Hader D.-P.,Friedrich - Alexander - University, Erlangen - Nuremberg | Erzinger G.S.,University of the Region of Joinville
Chemosphere | Year: 2017

The microcrustacean Daphnia is sensitive to many toxic substances and can be cultured easily. The Daphniatox instrument is based on computerized image analysis tracking swimming organisms in real time. The software evaluates 14 endpoints including motility, swimming velocity, orientation with respect to light and gravity as well as cell form and size. The system determines movement vectors of a large number of organisms to warrant high statistical significance and calculates mean values as well as standard deviation. Tests with K dichromate show that the toxin inhibits motility (EC50 0.75 mg/L), swimming velocity (EC50 0.70 mg/L) and even causes a significant decrease in length (16% at 4 mg/L) and changes the form of the animals, This bioassay can be used to monitor the toxicity of a large number of dissolved pollutants and toxic substances such as arsenic, dichromate and persistent organic pollutants. © 2016 Elsevier Ltd


de Oliveira E.L.,Hans Dieter Schmidt Regional Hospital | Westphal G.A.,Municipal Sao Jose Municipal Hospital | Mastroeni M.F.,University of the Region of Joinville
Brazilian Journal of Cardiovascular Surgery | Year: 2012

Objective: To describe the demographic and clinical characteristics of patients undergoing coronary artery bypass graft surgery (CABG) and to test their relation to mortality. Methods: This study was a retrospective medical record review of 655 consecutive patients undergoing CABG from May 2002 to April 2010. Results: Of the 655 patients, 12.1% died during the hospital stay. Mortality was significantly (p<0.05) higher in females (17.3%), aged < 70 years (22.8%), in emergency surgery (36.4%), in cases of readmission to the intensive care unit (ICU) (33.3%), when the stay in the ICU was < three days (16.3%), undergoing longer cardiopulmonary bypass (CPB), and with more comorbidities (15.4%). Predictor variables of death identified with logistical regression analysis were: female (OR=2.04), age > 70 years (OR=2.69), emergency surgery (OR=15.43) and urgency (OR=3.81), performance of CPB (OR=2.19) and readmission to the ICU (OR=4.33). Conclusion: Variables such as female sex, increased age, type of surgery, readmission to the ICU, ICU stay, comorbidities, and duration of CPB influence the outcome death in patients undergoing CABG. Thus, such aspects should be considered to reduce hospital mortality in patients undergoing such surgery.


Fernandes E.R.K.,University of the Region of Joinville | Marangoni C.,University of the Region of Joinville | Souza O.,University of the Region of Joinville | Sellin N.,University of the Region of Joinville
Energy Conversion and Management | Year: 2013

Wet and semi-dried banana leaves were characterized through elemental and proximate analyses, lignocellulosic fraction and thermogravimetric analysis (TG/DTG), differential scanning calorimetry (DSC) and high heating value analysis to assess their use as biomass in generating energy through combustion; they were also assessed to determine the potential of obtaining value-added products through pyrolysis. The wet banana leaves had high moisture content of 74.7%. The semi-dried samples exhibited 8.3% moisture, 78.8% volatile solids, 43.5% carbon and a higher heating value of 19.8 MJ/kg. The nitrogen and sulfur contents in the banana leaves were very low. The semi-dried and wet leaves had hemicellulose and lignin contents close to other biomass fuels, and the semi-dried leaves had the lowest cellulose content, of 26.7%. The wet and semi-dried samples showed the same thermal events in oxidizing and inert atmospheres, but with distinctly different mass loss and energy release intensities. The chemical characteristics and the thermal behavior demonstrated by the semi-dried samples indicate their potential for use as biomass, with results similar to other agro-industrial wastes currently used. © 2013 Elsevier Ltd. All rights reserved.


Franco S.C.,University of the Region of Joinville | Hernaez A.M.,Rovira i Virgili University
Ciencia e Saude Coletiva | Year: 2013

Distinct models of health management reflect the core principles upon which they were founded and their institutional arrangement can lead to the improvement of health policy. This paper seeks to reflect on the potential benefits and limitations of the organizational structure and the social capital to lead to changes in the performance of public health organizations in the quest for enhanced quality of care. The description and analysis of two experiences of universal public health systems, in Catalonia and in Brazil, reveal similarities in the legal basis of both health systems. However, the mode of deployment differed greatly, which gave rise to divergent management experiences. One prioritized managerial organization, while the other concentrated on the importance of the social actors promoting the institutionalization of social capital. It is suggested that models of management with dialogue between an efficient organizational design and citizen participation capable of constructing social capital may lead to change in the organizational culture and enhance the quality of care.


Romao L.M.,University of the Region of Joinville | Nievola J.C.,Pontifical Catholic University of Parana
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2012

The Gene Ontology (GO) project is a major bioinformatics initiative with the aim of standardizing the representation of gene and gene product attributes across species and databases. The classes in GO are hierarchically structured in the form of a directed acyclic graph (DAG), what makes its prediction more complex. This work proposes an adapted Learning Classifier Systems (LCS) in order to predict protein functions described in the GO format. Hence, the proposed approach, called HLCS (Hierarchical Learning Classifier System) builds a global classifier to predict all classes in the application domain and its is expressed as a set of IF-THEN classification rules, which have the advantage of representing more comprehensible knowledge. The HLCS is evaluated in four different ion-channel data sets structured in GO terms and compared with a Ant Colony Optimisation algorithm, named hAnt- Miner. In the tests realized the HLCS outperformed the hAnt-Miner in two out of four data sets. © Springer-Verlag Berlin Heidelberg 2012.


Scolaro B.,Regional University of Blumenau | Delwing-De Lima D.,University of the Region of Joinville | Da Cruz J.G.P.,Regional University of Blumenau | Delwing-Dal Magro D.,Regional University of Blumenau
Oxidative Medicine and Cellular Longevity | Year: 2012

Objective. The aim of this study was to evaluate the influence of acute and chronic intake of mate tea on the effects elicited by acute and chronic administration of ethanol. Methods. Oxidative stress was evaluated by measuring thiobarbituric acid-reactive substances (TBARS), as well as the activities of the antioxidant enzymes, catalase (CAT), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) in the hippocampus and blood of rats. Male Wistar rats were randomly assigned to four groups, for both acute and chronic treatment: (1) control group, (2) treated group, (3) intoxicated group, (4) and intoxicated group treated with mate tea. Results. Both ethanol administrations significantly increased TBARS in plasma and hippocampus of rats and altered antioxidant enzyme activities, changes which were reverted by mate tea administration. Conclusions. Data indicate that acute and chronic ethanol administration induced oxidative stress in hippocampus and blood and that mate tea treatment was able to prevent this situation. Copyright 2012 Bianca Scolaro et al.


Ferrari F.,University of the Region of Joinville | Reis M.A.M.,University of the Region of Joinville
World Journal of Gastroenterology | Year: 2013

Aim: To study the association between the incidence of gastric cancer and populational exposure to risk/protective factors through an analysis of international databases. Methods: Open-access global databases concerning the incidence of gastric cancer and its risk/protective factors were identified through an extensive search on the Web. As its distribution was neither normal nor symmetric, the cancer incidence of each country was categorized according to ranges of percentile distribution. The association of each risk/protective factor with exposure was measured between the extreme ranges of the incidence of gastric cancer (under the 25th percentile and above the 75th percentile) by the use of the Mann-Whitney test, considering a significance level of 0.05. Results: A variable amount of data omission was observed among all of the factors under study. A weak or nonexistent correlation between the incidence of gastric cancer and the study variables was shown by a visual analysis of scatterplot dispersion. In contrast, an analysis of categorized incidence revealed that the countries with the highest human development index (HDI) values had the highest rates of obesity in males and the highest consumption of alcohol, tobacco, fruits, vegetables and meat, which were associated with higher incidences of gastric cancer. There was no significant difference for the risk factors of obesity in females and fish consumption. Conclusion: Higher HDI values, coupled with a higher prevalence of male obesity and a higher per capita consumption of alcohol, tobacco, fruits, vegetables and meat, are associated with a higher incidence of gastric cancer based on an analysis of populational global data. © 2013 Baishideng Publishing Group Co., Limited. All rights reserved.


The association between attention deficit and hyperactivity disorder (ADHD) and epilepsy can cause significant impact on the social life of affected individuals and their families. Clinical studies suggest that 30-40% of people with epilepsy also have ADHD. There are no studies which demonstrate that short or long-term treatment with methylphenidate increases the risk of seizures. Some studies attempt to relate drug interactions between methylphenidate and antiepileptic drugs, but adverse effects of methylphenidate have not been shown clearly. This review presents some neurobiological and physiopathogenic aspects, common to ADHD and epilepsy, from recent research studies, related to pharmacology, neuroimaging and electroencephalography. Possible risk of occurrence of seizures associated with the use of methylphenidate are also discussed.


The present study provides information about the diet of sympatric populations of small cetaceans in the Babitonga Bay estuary. This is the first study on the diet of these species in direct sympatry. The stomach contents of seven Guiana dolphins Sotalia guianensis and eight franciscanas Pontoporia blainvillei were analyzed. The prey of both cetaceans was mostly teleost fishes, followed by cephalopods. We identified 13 teleost fishes as part of the diet of the franciscanas, and 20 as part of the diet of Guiana dolphins. Lolliguncula brevis was the only cephalopod recorded, and was the most important prey for both cetaceans. Stellifer rastrifer and Gobionellus oceanicus were also important for franciscana, so as Mugil curema and Micropogonias furnieri were important for Guiana dolphins. Stellifer rastrifer and Cetengraulis edentulus were the fishes with the highest frequency of occurrence for franciscana (50%), while Achirus lineatus, C. edentulus, S. brasiliensis, Cynoscion leiarchus, M. furnieri, M. curema, Diapterus rhombeus, Eugerres brasilianus and G. oceanicus showed 28.6% of frequency of occurrence for Guiana dolphins. Franciscanas captured greater cephalopods than the Guiana dolphins in both total length (z= -3.38; n= 40; p< 0.05) and biomass (z = -2.46; n = 40; p<0.05). All of the prey species identified occur inside the estuary, which represents a safe habitat against predators and food availability, reinforcing the importance of the Babitonga Bay for these cetacean populations.


Gumboski E.L.,University of the Region of Joinville
Lichenologist | Year: 2015

Calopadia saxicola is described as new to science. The species grows on rocky shores in southern Brazil and is characterized by the corticate thallus, pruinose apothecia with brownish to reddish brown disc, mainly 2-3-spored asci with muriform ascospores, and the absence of secondary metabolites. A description with ecological data, figures, comments and a key to all species in the genus known from Brazil are given. © 2015 British Lichen Society.

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