University of the East of Cuba

Santiago de Cuba, Cuba

University of the East of Cuba

Santiago de Cuba, Cuba
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Speck-Planche A.,University of Porto | Speck-Planche A.,University of the East of Cuba | Cordeiro M.N.D.S.,University of Porto
Current Topics in Medicinal Chemistry | Year: 2012

Hepatitis C constitutes an infectious disease that causes severe damages to the liver, and is caused by hepatitis C virus. There is no vaccine against this type of disease and the number of people infected continues to grow worldwide. The anti-viral therapy which is currently used is a mixture of interferon alpha-2a with ribavirin, but approximately half of the patients do not respond to therapy. Therefore, it is necessary to search for new compounds with anti-hepatitis C activity. Computer-aided drug design methodologies have been vital in the discovery of candidates to drugs. This review is dedicated to the role of computer-aided drug design methodologies for the development of new anti-hepatitis C agents. In addition, we introduce a QSAR model based on substructural approaches in order to model the anti-hepatitis C activity in vivo. © 2012 Bentham Science Publishers.

Speck-Planche A.,University of the East of Cuba | Scotti M.T.,Federal University of Paraiba | de Paulo-Emerenciano V.,University of Sao Paulo
Current Pharmaceutical Design | Year: 2010

The increasing resistance of Mycobacterium tuberculosis to the existing drugs has alarmed the worldwide scientific community. In an attempt to overcome this problem computer-aided drug design has provide an extraordinary support to the different strategies in drug discovery. There are around 250 biological receptors such as enzymes that can be used in principle, for the design of antituberculosis compounds that act by a specific mechanism of action. Also, there more than 5000 compound available in the literature, and that constitute important information in order to search new molecular patterns for the design of new antituberculosis agents. The purpose of this paper is to explored the current state of drug discovery of antituberculosis agents and how the different strategies supported by computeraided drug design methods has influenced in a determinant way in the design of new molecular entities that can result the future antituberculosis drugs. © 2010 Bentham Science Publishers Ltd.

The pharmaceutical preparations marketed in pharmacies of the Eastern region of Cuba during the 19th and 20th centuries were described. The formulations were characterized by their components and indications in addition to presenting the most demanded pharmaceutical specialties at that time. The national and foreignspecialties and their suppliers were also reported. The commercialization of pharmaceutical preparations in the Eastern region was characterized at the end of the XIX century and first half of the XX century by a gradual rise of sale of pharmaceutical specialties, mainly from the United States of America and France; however this did not go against the preparations in dispensaries where deep-rooted traditions and gradual evolution of pharmaceutical profession assured wide range of products in the pharmacies of the Eastern region. © 2016, Editorial Ciencias Medicas. All rights reserved.

Mockey Coureaux I.O.,University of the East of Cuba | Manzano E.,National University of Tucuman
Energy for Sustainable Development | Year: 2013

Road lighting facilities operate for over half of a year but they are permanently subjected to adverse weather conditions and environmental pollution. The major cause of the loss of light is generally the accumulation of dirt on the luminaires (lamps and lighting fixtures).The severity of the loss (depreciation) depends on the nature and density of environmental pollution and the degree of protection of the luminaires against dust and water. This depreciation is compensated, beginning from the design stage, by over-sizing facilities and, throughout its lifetime, by maintenance programs. There are several ways of estimating depreciation. This paper is a review of the different sources of information and findings of major investigations conducted in recent times. There is strong evidence which indicates that luminaire depreciation could be based on the level of sealing of the luminaires and on environment pollution categories. Luminaires with IP6X degree protection are only slightly influenced by environment pollution. New generations of LED luminaires are built to conform to IP6 and this will probably soon be the standard for road and urban lighting luminaires. Even if these luminaires have a higher rate of lamp survival, an exterior cleaning operation is still necessary and the luminaire depreciation behaviour model will still be useful. It is important to select a convenient maintenance factor to compensate for depreciation and to reduce the number of installed fixtures or the amount of over sizing of lamp power, which significantly transcends the energy and environmental impact. © 2013 International Energy Initiative.

Speck-Planche A.,University of the East of Cuba | Kleandrova V.V.,Moscow State University of Food Production
Molecular Diversity | Year: 2012

Rational design of entry inhibitors is an active area for the discovery of new and effective anti-HIV agents. C-C Chemokine receptors represent key targets for the HIV entry process. Several of these proteins with features to be HIV co-receptors have not been sufficiently studied or used for the design of novel entry inhibitors. With the purpose to overcome this problem, we develop here a fragment-based approach for the design of multi-target inhibitors against four C-C chemokine receptors. This approach was focused on the construction of a multi-target QSAR discriminant model using a large and heterogeneous database of compounds and substructural descriptors for the classification and prediction of inhibitors for C-C chemokine receptors. The model correctly classified more than 89% of active and inactive compounds in both: training and prediction series. As principal advantage, this model permitted the automatic and fast extraction of fragments responsible for the inhibitory activity against the different C-C chemokine receptors under study and new molecular entities were suggested as possible versatile inhibitors for these proteins. © 2011 Springer Science+Business Media B.V.

Reyes J.B.,University of the East of Cuba | Shapiro M.,Escuela Superior de Fisica y Matematicas
Mathematical Methods in the Applied Sciences | Year: 2010

For a positive integer n let Cl0,n be the universal Clifford algebra with the signature (0,n). The name Clifford analysis is usually referred to the function theories for functions in the kernels of the two operators: the (Cliffordian) Cauchy- Riemann operator and the Dirac operator. For n = 2, Cl0,2 becomes the skew-field of Hamilton's quaternions for which the two operators are widely known: the Moisil-Théodoresco and the Fueter operators. We establish the precise relations between the Moisil-Théodoresco operator and the Dirac operator for Cl0,3. It turns out that the case of the Cauchy- Riemann operator for Cl0,3 and the Fueter operator is more sophisticated, and we describe the peculiarities emerging here. © 2009 John Wiley & Sons, Ltd.

Speck-Planche A.,University of the East of Cuba | Kleandrova V.V.,Moscow State University of Food Production | Rojas-Vargas J.A.,University of the East of Cuba
Molecular Diversity | Year: 2011

The increasing resistance of several phytopathogenic fungal species to the existing agrochemical fungicides has alarmed to the worldwide scientific community. There is no available methodology to predict in an efficient way if a new fungicide will have resistance risk due to fungal species which cause considerable crop losses. In an attempt to overcome this problem, a multi-resistance risk QSAR model, based on substructural descriptors was developed from a heterogeneous database of compounds. The purpose of this model is the classification, design, and prediction of agrochemical fungicides according to resistance risk categories. The QSAR model classified correctly 85.11% of the fungicides and the 85.07% of the inactive compounds in the training series, for an accuracy of 85.08%. In the prediction series, the percentages of correct classification were 85.71 and 86.55% for fungicides and inactive compounds, respectively, with an accuracy of 86.39%. Some fragments were extracted and their quantitative contributions to the fungicidal activity were calculated taking into consideration the different resistance risk categories for agrochemical fungicides. In the same way, some fragments present in molecules with fungicidal activity and with negative contributions were analyzed like structural alerts responsible of resistance risk. © 2011 Springer Science+Business Media B.V.

Portuondo I.P.,University of the East of Cuba
Revista Cubana de Salud Publica | Year: 2012

Introduction: Gram positive bacterium Bacillus cereus is widely distributed in the environment. This bacterium is responsible for two food poisoning syndromes (emetic and diarrheal) and also it has been related to other diseases such as endocarditis and endophthalmitis; therefore it is recognized as opportunist pathogen. Objective: to review the information about Bacillus cereus toxins and its connection with food poisoning, as well as to address others factors influencing this bacterium's virulence. Data sources: for collecting this information, search engines such as Google and Scirus. Reviewed articles included research articles, systematic reviews on this topic and free accessed book chapters, or requested from the authors. Data synthesis: the review delved into Knowledge on diarrheal and emetic toxins, clinical symptomatology and time of occurrence, as soon as foodstuffs involved in each syndrome. This helps the clinician to look for the causes of toxin infections. A general overview of Bacillus cereus microbiology and others factors that explain its virulence and other implications in the human health was given. Conclusions: the acquired knowledge shows that Bacillus cereus is one bacterium with clinical importance rather than a mere environmental pollutant.

Kleandrova V.V.,Moscow State University of Food Production | Speck-Planche A.,University of the East of Cuba
Frontiers in Bioscience - Elite | Year: 2013

The chemical risk assessment is determinant for the approval of any kind of chemical. Each aspect of chemical is taken into consideration for the new chemical legislation registration, evaluation, and authorization of chemicals (REACH). However, some improvements can be made in order to select and authorize a chemical. QSAR techniques have been used for the study of several kind of toxicological properties in order to realize a deeper study concerning to risk assessment. For this reason, this work is focused into present a review of chemical legislation policies in the European Union (EU) and in Russia, and changes in chemicals regulations to meet the requirement of REACH. Also, we reported the used of several approaches and chemo-bioinformatics tools applied to QSAR methodologies for the several parameters relative to toxicity and how they can be used for regulatory purposes in risk assessment.

Gil-Garcia R.,University of the East of Cuba | Pons-Porrata A.,University of the East of Cuba
Pattern Recognition Letters | Year: 2010

In this paper, two clustering algorithms called dynamic hierarchical compact and dynamic hierarchical star are presented. Both methods aim to construct a cluster hierarchy, dealing with dynamic data sets. The first creates disjoint hierarchies of clusters, while the second obtains overlapped hierarchies. The experimental results on several benchmark text collections show that these methods not only are suitable for producing hierarchical clustering solutions in dynamic environments effectively and efficiently, but also offer hierarchies easier to browse than traditional algorithms. Therefore, we advocate its use for tasks that require dynamic clustering, such as information organization, creation of document taxonomies and hierarchical topic detection. © 2009 Elsevier B.V. All rights reserved.

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