University of the Chinese

Beijing, China

University of the Chinese

Beijing, China
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Yao H.,CAS Institute of Computing Technology | Yao H.,University of the Chinese | Zhang S.,Peking University | Zhang Y.,CAS Institute of Computing Technology | And 3 more authors.
IEEE Transactions on Image Processing | Year: 2016

Recent years have witnessed the significant advance in fine-grained visual categorization, which targets to classify the objects belonging to the same species. To capture enough subtle visual differences and build discriminative visual description, most of the existing methods heavily rely on the artificial part annotations, which are expensive to collect in real applications. Motivated to conquer this issue, this paper proposes a multi-level coarse-to-fine object description. This novel description only requires the original image as input, but could automatically generate visual descriptions discriminative enough for fine-grained visual categorization. This description is extracted from five sources representing coarse-to-fine visual clues: 1) original image is used as the source of global visual clue; 2) object bounding boxes are generated using convolutional neural network (CNN); 3) with the generated bounding box, foreground is segmented using the proposed k nearest neighbour-based co-segmentation algorithm; and 4) two types of part segmentations are generated by dividing the foreground with an unsupervised part learning strategy. The final description is generated by feeding these sources into CNN models and concatenating their outputs. Experiments on two public benchmark data sets show the impressive performance of this coarse-to-fine description, i.e., classification accuracy achieves 82.5% on CUB-200-2011, and 86.9% on fine-grained visual categorization-Aircraft, respectively, which outperform many recent works. © 2016 IEEE.

News Article | November 15, 2016

SHANGHAI, Nov. 15, 2016 /PRNewswire/ -- Semiconductor Manufacturing International Corporation ("SMIC"; NYSE: SMI; SEHK: 981), one of the leading semiconductor foundries in the world and the largest and most advanced foundry in mainland China, and The Institute of Microelectronics of the Chinese Academy of Sciences ("IMECAS") announced the signing of a cooperation agreement for a MEMS R&D foundry platform to jointly develop MEMS sensor standard processes and build a complete MEMS supply chain. According to the agreement, SMIC and IMECAS will work together closely to take advantage of IMECAS's experiences in MEMS Sensor design and packaging technology design and SMIC's standardized process technology platforms, industry and market influence. Starting with the development of a MEMS environmental sensor and combining the features of other types of MEMS Sensors, SMIC and IMECAS will collaborate to create a platform-based standard as well as mass production technologies to shorten the development cycle from design to production, thus helping the MEMS industry grow more effectively and efficiently. "SMIC's R&D team has made a lot of achievements in developing new sensor technology platforms and introducing new customers. SMIC is willing to open our platforms to support commercialized production and the R&D of universities and research institutions," said Dr. Tzu-Yin Chiu, Chief Executive Officer and Executive Director of SMIC. "SMIC and IMECAS have cooperated in numerous logic process development projects. This time we will expand our collaboration and promote the R&D of complete standardized MEMS sensor technologies to help integrate and improve the MEMS supply chain." Ye Tianchun, Director of IMECAS, visited SMIC's middle-end production line of MEMS sensors and said, "Through the cooperation between SMIC and IMECAS, we can exploit our advantages and jointly build an open MEMS technology service platform and an electronic information integration platform for the MEMS supply chain. With the integration of design, manufacturing, packing, testing, public platform and venture investment, we can form a supply chain ecosystem and support the development of a global as well as domestic Chinese MEMS industry." Semiconductor Manufacturing International Corporation ("SMIC"; NYSE: SMI; SEHK: 981) is one of the leading semiconductor foundries in the world and the largest and most advanced foundry in mainland China. SMIC provides integrated circuit (IC) foundry and technology services on process nodes from 0.35 micron to 28 nanometer. Headquartered in Shanghai, China, SMIC has an international manufacturing and service base. In China, SMIC has a 300mm wafer fabrication facility (fab) and a 200mm mega-fab in Shanghai; a 300mm mega-fab and a majority-owned 300mm fab for advanced nodes in Beijing; 200mm fabs in Tianjin and Shenzhen; and a majority-owned joint-venture 300mm bumping facility in Jiangyin; additionally, in Italy SMIC has a majority-owned 200mm fab. SMIC also has marketing and customer service offices in the U.S., Europe, Japan, and Taiwan, and a representative office in Hong Kong. For more information, please visit This press release contains, in addition to historical information, "forward-looking statements" within the meaning of the "safe harbor" provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements, including statements under "Fourth Quarter 2016 Guidance", "CapEx Summary" and the statements contained in the quotes of our CEO are based on SMIC's current assumptions, expectations and projections about future events. SMIC uses words like "believe," "anticipate," "intend," "estimate," "expect," "project," "target" and similar expressions to identify forward-looking statements, although not all forward-looking statements contain these words. These forward-looking statements involve significant risks, both known and unknown, uncertainties and other factors that may cause SMIC's actual performance, financial condition or results of operations to be materially different from those suggested by the forward-looking statements including, among others, risks associated with the cyclical nature of the semiconductor industry, changes in demand for our products, competition in our markets, our reliance on a small number of customers, orders or judgments from pending litigation, intensive intellectual property lawsuits in semiconductor industry and financial stability in end markets, general economic conditions and fluctuations in currency exchange rates. Investors should consider the information contained in SMIC's filings with the U.S. Securities and Exchange Commission ("SEC"), including its annual report on 20-F filed with the SEC on April 25, 2016, especially the consolidated financial statements, and such other documents that SMIC may file with the SEC or The Hong Kong Stock Exchange Limited ("SEHK") from time to time, including current reports on Form 6-K. Other unknown or unpredictable factors also could have material adverse effects on SMIC's future results, performance or achievements. In light of these risks, uncertainties, assumptions and factors, the forward-looking events discussed in this press release may not occur. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date stated, or if no date is stated, as of the date of this press release. Except as may be required by law, SMIC undertakes no obligation and does not intend to update any forward-looking statement, whether as a result of new information, future events or otherwise. The Institute of Microelectronics of the Chinese Academy of Sciences ("IMECAS") has become a key research institution integrated with both fundamental research and technology development, which is quite industry-oriented. It is also an entity of two centers and one college under the name of CAS. They are the CAS R&D Center for The Internet of Things, the CAS EDA Center (Electronic Design Automation Center) and the college of Microelectronics of UCAS (University of the Chinese Academy of Sciences). There are 14 departments at IMECAS including two key CAS Laboratories, four R&D centers for industry service, five R&D centers for typical applications, and three R&D centers for core product development. Among which, the Smart Sensing Center is conducting the research and development of sensor design, fabrication, packaging and testing. The CAS R&D Center for The Internet of Things has also established public service platforms, including a MEMS Design and Manufacture Platform and SIP Packaging Platform, a Communication System and Chip Design Test and Verification Platform, and more. For more information, please visit

Zhang W.-C.,University of the Chinese | Zheng X.-J.,University of the Chinese | Du L.-J.,University of the Chinese | Sun J.-Y.,University of the Chinese | And 20 more authors.
Cell Research | Year: 2015

High salt is positively associated with the risk of many diseases. However, little is known about the mechanisms. Here we showed that high salt increased proinflammatory molecules, while decreased anti-inflammatory and proendocytic molecules in both human and mouse macrophages. High salt also potentiated lipopolysaccharide-induced macrophage activation and suppressed interleukin 4-induced macrophage activation. High salt induced the proinflammatory aspects by activating p38/cFos and/or Erk1/2/cFos pathways, while inhibited the anti-inflammatory and proendocytic aspects by Erk1/2/signal transducer and activator of transcription 6 pathway. Consistent with the in vitro results, high-salt diet increased proinflammatory gene expression of mouse alveolar macrophages. In mouse models of acute lung injury, high-salt diet aggravated lipopolysaccharide-induced pulmonary macrophage activation and inflammation in lungs. These results identify a novel macrophage activation state, M(Na), and high salt as a potential environmental risk factor for lung inflammation through the induction of M(Na). © 2015 IBCB, SIBS, CAS.

Wu Q.,University of the Chinese | Wu Q.,Zhejiang University | Wang H.,University of the Chinese | Wang H.,Zhejiang University | And 11 more authors.
Antioxidants and Redox Signaling | Year: 2015

Hereditary hemochromatosis (HH) is an iron overload disease that is caused by mutations in HFE, HJV, and several other genes. However, whether HFE-HH and HJV-HH share a common pathway via hepcidin regulation is currently unclear. Recently, some HH patients have been reported to carry concurrent mutations in both the HFE and HJV genes. To dissect the roles and molecular mechanisms of HFE and/or HJV in the pathogenesis of HH, we studied Hfe-/-, Hjv-/-, and Hfe-/-Hjv-/- double-knockout mouse models. Results: Hfe-/-Hjv-/- mice developed iron overload in multiple organs at levels comparable to Hjv-/- mice. After an acute delivery of iron, the expression of hepcidin (i.e., Hamp1 mRNA) was increased in the livers of wild-type and Hfe-/- mice, but not in either Hjv-/- or Hfe-/-Hjv-/- mice. Furthermore, iron-induced phosphorylation of Smad1/5/8 was not detected in the livers of Hjv-/- or Hfe-/-Hjv-/- mice. Innovation: We generated and phenotypically characterized Hfe-/-Hjv-/- double-knockout mice. In addition, because they faithfully phenocopy clinical HH patients, these mouse models are an invaluable tool for mechanistically dissecting how HFE and HJV regulate hepcidin expression. Conclusions: Based on our results, we conclude that HFE may depend on HJV for transferrin-dependent hepcidin regulation. The presence of residual hepcidin in the absence of HFE suggests either the presence of an unknown regulator (e.g., TFR2) that is synergistic with HJV or that HJV is sufficient to maintain basal levels of hepcidin. Antioxid. Redox Signal. 22, 1325-1336. © 2015 Mary Ann Liebert, Inc.

Chen L.,Sun Yat Sen University | Ding M.-L.,Sun Yat Sen University | Wu F.,Sun Yat Sen University | He W.,Sun Yat Sen University | And 6 more authors.
Hypertension | Year: 2016

Although hyperaldosteronemia exerts detrimental impacts on vascular endothelium in addition to elevating blood pressure, the effects and molecular mechanisms of hyperaldosteronemia on early endothelial progenitor cell (EPC)-mediated endothelial repair after arterial damage are yet to be determined. The aim of this study was to investigate the endothelial repair capacity of early EPCs from hypertensive patients with primary hyperaldosteronemia (PHA). In vivo endothelial repair capacity of early EPCs from PHAs (n=20), age-and blood pressure-matched essential hypertension patients (n=20), and age-matched healthy subjects (n=20) was evaluated by transplantation into a nude mouse carotid endothelial denudation model. Endothelial function was evaluated by flow-mediated dilation of brachial artery in human subjects. In vivo endothelial repair capacity of early EPCs and flow-mediated dilation were impaired both in PHAs and in essential hypertension patients when compared with age-matched healthy subjects; however, the early EPC in vivo endothelial repair capacity and flow-mediated dilation of PHAs were impaired more severely than essential hypertension patients. Oral spironolactone improved early EPC in vivo endothelial repair capacity and flow-mediated dilation of PHAs. Increased oxidative stress, oxidative 5,6,7,8-tetrahydrobiopterin degradation, endothelial nitric oxide synthase uncoupling and decreased nitric oxide production were found in early EPCs from PHAs. Nicotinamide adenine dinucleotide phosphate oxidase subunit p47phox knockdown or 5,6,7,8-tetrahydrobiopterin supplementation attenuated endothelial nitric oxide synthase uncoupling and enhanced in vivo endothelial repair capacity of early EPCs from PHAs. In conclusion, PHAs exhibited more impaired endothelial repair capacity of early EPCs than did essential hypertension patients independent of blood pressure, which was associated with mineralocorticoid receptor-dependent oxidative stress and subsequently 5,6,7,8-tetrahydrobiopterin degradation and endothelial nitric oxide synthase uncoupling. © 2015 American Heart Association, Inc.

Zhang D.-Y.,CAS Dalian Institute of Chemical Physics | Zhang D.-Y.,University of the Chinese | Shao L.,CAS Dalian Institute of Chemical Physics | Shao L.,University of the Chinese | And 2 more authors.
ACS Catalysis | Year: 2015

A catalytic asymmetric [3 + 2] cycloaddition of hydrazines to bis-electrophilic C3 synthons generated from propargylic acetates, followed by an intramolecular 1,3-H migration, for the regio- and enantioselective construction of chiral 2-pyrazolines has been reported. By employment of copper catalysis in combination with a structurally rigid tridentate P,N,N-ligand, a variety of chiral 2-pyrazolines were obtained in good yields and with high enantioselectivities (up to 96% ee). A possible transition state has been proposed to explain the origin of the regio- and enantioselectivities. © 2015 American Chemical Society.

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