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University of Technology of Compiègne, France

Chattopadhyay C.,University of Texas M. D. Anderson Cancer Center | Kim D.W.,H. Lee Moffitt Cancer Center and Research Institute | Gombos D.S.,The University of Texas Anderson Cancer Center | Oba J.,University of Texas M. D. Anderson Cancer Center | And 6 more authors.
Cancer | Year: 2016

Melanomas of the choroid, ciliary body, and iris of the eye are collectively known as uveal melanomas. These cancers represent 5% of all melanoma diagnoses in the United States, and their age-adjusted risk is 5 per 1 million population. These less frequent melanomas are dissimilar to their more common cutaneous melanoma relative, with differing risk factors, primary treatment, anatomic spread, molecular changes, and responses to systemic therapy. Once uveal melanoma becomes metastatic, therapy options are limited and are often extrapolated from cutaneous melanoma therapies despite the routine exclusion of patients with uveal melanoma from clinical trials. Clinical trials directed at uveal melanoma have been completed or are in progress, and data from these well designed investigations will help guide future directions in this orphan disease. © 2016 American Cancer Society.

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