The University of Szczecin is a public university in Szczecin, western Poland. It is the biggest university in West Pomerania, with 33,267 students and a staff of nearly 1,200. It consists of 9 faculties: Faculty of Humanities Faculty of Law and Administration Faculty of Natural science Faculty of Mathematics and Physics Faculty of Economics and Management Faculty of Management and Economics of Services Faculty of Theology Faculty of Geoscience Faculty of PhilologySince 1998, the University has been taking part in the Erasmus student exchange programme. Wikipedia.
Kruk J.,University Of Szczecin |
Kubasik-Kladna K.,Pomeranian Medical University |
Aboul-Enein H.Y.,National Research Center of Egypt
Mini-Reviews in Medicinal Chemistry | Year: 2016
Extensive research during the past three decades has demonstrated the mechanisms by which an imbalance in the redox status of prooxidant/antioxidant reactions in cells with advantage of prooxidant reactions (oxidative stress, OS) can cause peroxidation of nucleic acids, bases, lipids, proteins and carbohydrates, thus resulting in their damage. These actions result in stimulation of signal transduction pathways and activation of transcription factors that can lead to chronic inflammation and cause tissue dysfunction. The most important oxidants are reactive oxygen species (ROS) and reactive nitrogen species (RNS) generated by various metabolic pathways, physical, chemical and biological factors, and pathological conditions. The eye is one of the major target of the ROS/RNS attack due to exposition on several environmental factors like high pressure of oxygen, light exposure, ultraviolet rays, ionizing radiation, chemical pollutants, irritant, and pathogenic microbes, which are able to shift the redox status of a cell towards oxidizing conditions. There is increasing evidence indicating that persistent OS contributes to the development of many ocular diseases. Increases in the accumulation of hydrogen peroxide and markers of the oxidative damage to DNA, lipids, proteins observed in several eye diseases and usage of antioxidants in their treatment and prevention emphasize the involvement of OS pathways. This paper summarizes the present state of knowledge in the involvement of OS in the etiology of non-cancer ocular diseases (dry eye syndrome; corneal and conjunctive diseases; cataract; glaucoma; age-related macular degeneration; retinitis pigmentosa; diabetic retinopathy, autoimmune and inflammatory uveitis) and cancer ocular diseases (melanoma; retinoblastoma; lymphoma). The paper also discusses the potential applications of antioxidants in the prevention of eye diseases and shows a duality of physical exercise actions: protection against the ROS/RNS damage by regular-moderate physical activity and damaging effect through mediation of OS by endurance exercise without adaptable physical training. © 2016 Bentham Science Publishers.
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 1.60M | Year: 2017
The GHaNA project aims to explore and characterize a new marine bioresource, for blue biotechnology applications in aquaculture, cosmetics and possibly food and health industry. The project will determine the biological and chemical diversity of Haslea diatoms to develop mass-scale production for viable industrial applications by maximising biomass production and associated high-value compound production, including terpenoids, marennine-like pigments, lipids and silica skeletons. The genus Haslea species type H. ostrearia, produces marennine, a water-soluble blue pigment used for greening oysters in Western France, which is also a bioactive molecule. Haslea diatoms have thus a high potential for use in (1) existing oyster farming, (2) production of pigments and bioactive compounds with natural antibacterial properties, (3) application as a colouring agent within industry, and (4) use of silica skeletons as inorganic biocharges in the formulation of new elastomeric materials. This will be achieved through fundamental and applied-oriented research to isolate fast- growing strains of Haslea, optimising their growth environment to increase marennine and other high-value compound productivity; to develop blue biotechnology specifically applied to benthic microalgae (biorefinery approach, processes); and to develop industrial exploitation of colouring and bioactive compounds through commercial activities of aquaculture, food, cosmetics and health.
Kruk J.,University Of Szczecin
Asian Pacific Journal of Cancer Prevention | Year: 2014
Background: Although the nutritional may exert effect on the breast cancer risk, it is not clear whether the role diet is the same in sedentary and physically active women. The aim of this study was to evaluate the association between fruit, vegetable and carbohydrate intake and the risk of breast cancer among Polish women considering their physical activity level. Materials and Methods: A case-control study was conducted that included 858 women with histological confirmed breast cancer and 1,085 controls, free of any cancer diagnosis, aged 28-78 years. The study was based on a self-administered questionnaire to ascertain physical activity, dietary intake, sociodemographic characteristics, reproductive factors, family history of breast cancer, current weight and high, and other lifestyle factors. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated in unconditional logistic regression analyses including a broad range of potential confounders. Results: With comparison of the highest vs lowest quartile of intake, strong significant associations were observed for total vegetables (OR=0.37, 95%CI=0.20-0.69 P for trend <0.01 and OR=0.53, 95%CI=0.29-0.96, P for trend <0.02), and total fruits (OR=0.47, 95%CI=0.25-0.87, P for trend <0.05 and OR=0.47, 95%CI=0.24-0.90, P for trend <0.02) among women characterized by the lowest and the highest quartile of physical activity. No associations were observed for total carbohydrate intake. Additional analysis showed a positive association for sweets and desert intake among women in the lowest quartile of physical activity (OR=3.49, 95%CI=1.67-7.30, P for trend <0.009) for extreme quartiles of intake comparing to the referent group. Conclusions: The results suggest that a higher consumption of vegetable and fruit may be associated with a decreased risk of breast cancer, especially among women who were low or most physically active throughout their lifetimes. These findings do not support an association between diet high in carbohydrate and breast cancer. However, a higher intake of sweets and deserts may by associated with an increased risk of breast cancer among women who were less physically active.
Puc M.,University Of Szczecin
International Journal of Biometeorology | Year: 2012
Birch pollen is one of the main causes of allergy during spring and early summer in northern and central Europe. The aim of this study was to create a forecast model that can accurately predict daily average concentrations of Betula sp. pollen grains in the atmosphere of Szczecin, Poland. In order to achieve this, a novel data analysis technique-artificial neural networks (ANN)-was used. Sampling was carried out using a volumetric spore trap of the Hirst design in Szczecin during 2003-2009. Spearman's rank correlation analysis revealed that humidity had a strong negative correlation with Betula pollen concentrations. Significant positive correlations were observed for maximum temperature, average temperature, minimum temperature and precipitation. The ANN resulted in multilayer perceptrons 366 8: 2928-7-1:1, time series prediction was of quite high accuracy (SD Ratio between 0.3 and 0.5, R> 0.85). Direct comparison of the observed and calculated values confirmed good performance of the model and its ability to recreate most of the variation. © 2011 The Author(s).
Lubkowska A.,University Of Szczecin
Journal of biological regulators and homeostatic agents | Year: 2012
This paper reviews available reports on the advantages and possibilities of clinical use of platelet-rich plasma preparations, with particular emphasis on platelet growth factors. Platelets, an important reservoir of growth factors in the body, play an important role in many processes such as coagulation, immune response, angiogenesis and the healing of damaged tissues. Numerous proteins are contained in the alpha-granules of platelets: platelet-derived growth factor (PDGF), transforming growth factor (TGF), platelet factor interleukin (IL), platelet-derived angiogenesis factor (PDAF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), insulin-like growth factor IGF and fibronectin. The development of methods and systems for blood and cell sorting (e.g. CAPSS - compact advanced platelet sequestration system Elektromedics 500, PCCS - platelet concentrate collection system Curasan) have made it possible to obtain significant concentrations of platelets (even by 338 percent) and high concentrations of growth factors, in a form of sterile mass that can be used immediately for clinical purposes. Platelet-rich plasma (PRP; autologous platelet-rich plasma - APRP) are platelet concentrates made of autogenous blood with a high number of platelets in a small volume of plasma. The clinical efficacy of platelet concentrates depends mainly on the number of platelets and the concentration of their growth factors, which act as transmitters in most processes in tissues, particularly in healing where they are responsible for proliferation, differentiation, chemotaxis and tissue morphogenesis. They operate as part of autocrine, paracrine and endocrine mechanisms. Growth factors derived from centrifuged blood were first used in patients with chronic skin ulcers. The clinical use of PRP for a wide variety of applications has been reported mostly in oral and maxillo-facial surgery, orthopedic surgery, treatment of soft tissue diseases and injuries, treatment of burns, hard-to-heal wounds, tissue engineering and implantology.
Buchowiecki M.,University Of Szczecin
Chemical Physics Letters | Year: 2012
Temperature dependence of the rate constant of the NH 3 + H → NH 2 + H 2 reaction and its reverse was calculated for 200-1000 K temperature range within the quantum instanton method. The potential energy surface PES-1997 was used. Not being of the heavy-light-heavy type, the hydrogen abstraction by another hydrogen allows safe neglection of recrossing effects. Curvature of the Arrhenius plot is present at low temperatures, which is indicative of quantum effects due to light hydrogen atoms. Additionally, a fully quantum mechanical method of calculating the temperature dependence of the equilibrium constant is presented and applied. The method is based upon path-integral Monte Carlo simulations and subsequently on thermodynamic integration. © 2012 Elsevier B.V. All rights reserved.
Wodecka B.,University Of Szczecin
Applied and Environmental Microbiology | Year: 2011
A new protocol employing nested PCR-restriction fragment length polymorphism (RFLP) based on the flaB gene and two restriction enzymes was worked out. This protocol allows the identification of all Borrelia species transmitted by Ixodes ricinus in Europe, including Borrelia miyamotoi and 3 genetic variants of B. garinii. A dendrogram of flaB sequence similarity was in accordance with RFLP variants. © 2011, American Society for Microbiology.
Kruk J.,University Of Szczecin
Asian Pacific Journal of Cancer Prevention | Year: 2014
Breast cancer primary prevention is a high research priority due to the high psychological and economic costs. The disease is a multistep process and several risk factors have been recognized. Over the past three decades numerous studies have investigated the association of lifestyle with breast cancer, showing independent effects of various factors. We report here a summary of the present state of knowledge on the role of lifestyle patterns, such as physical activity, diet, smoking, hormone therapy, and experience of psychological stress in the modulation of breast cancer in women, and discuss commonly accepted biological mechanisms hypothesized as responsible for the associations. The findings indicate that regular physical activity of moderate to vigorous intensity is probably linked with the decreased breast cancer risk among postmenopausal females and suggestive for a decrease of the risk in premenopausal women. In contrast, the consumption of high-fat diet, alcohol intake, and use of combined estrogen and synthetic progestagen hormonal therapy may increase the risk. Epidemiological findings dealing with a role of smoking and experience of psychological stress are conflicting.
Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2010-IRSES | Award Amount: 670.70K | Year: 2011
The objective of PRORES project is transfer of knowledge in the field of restructuring from three perspectives: economic, ecological and social development. That is why four well prepared Universities from Ukraine, Lithuania and Poland were chosen to carried out the activity. Special attention in the project is given to early stage researchers. Due to project they will take an extensive training in hosting countries. Acquiring knowledge on these perspectives will allow gaining skills necessary to more efficient solving of restructuring problems in European and local markets. Even if PRORES project concerns mobility as a primary objective, the interdisciplinary research is also an important part. The project makes environmental issues central to research on organisational restructuring, stressing the ecological and the social issues. Basic methodology that will be used in project will be a case study covering selected companies in project partner countries. The results of the research, as a form of new knowledge, will be disseminated amongst different stakeholders of pro-ecological restructuring. Currently, the projects topic is of importance for several reasons. Firstly, in the context of the current global financial crisis organisational restructuring processes are widespread across Europe and are especially painful for workers selected for redundancy and their communities. Secondly, the ecological perspective in research is absent. Thirdly, this issue is especially urgent because of the imperatives of climate change and the EU policies aimed at securing a transition to a low carbon economy in both the EU and wider Europe, as Europe 2020: A European strategy for smart, sustainable and inclusive growth. Fourthly, projects partners perfectly fit for implementing and strengthening European Neighbourhood Policy. Moreover, Ukraine is a very important EU neighbour from not only economic but also social and political perspective.
Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2012-IRSES | Award Amount: 182.40K | Year: 2013
Undertaking the problem of culture of trust in the use of information and communication technology in education is justified by an increase in the number of available technological tools and associated with this the valuation and educational usefulness of digital information. The main task of the project is to learn the elements of the culture of trust in order to understand the behavior of educational entities in situations of the usage of ICT tools and programs in globalizing societies. The object of study is formal education, non-formal and informal. The research will be carried out in diverse environments in terms of education, history, economy, politics and religion from a perspective of: critical and emancipator pedagogy (Poland), multimedia learning (Norway), sensory learning (Germany), value pedagogy (India), pedagogical aspects of evaluation (China), pragmatic pedagogy and social constructivism (USA). It is important to discover the elements of a culture of trust in consideration of diverse media messages because of their source (who is the author of the information, opinion, appeal, advice), content (what is the subject of information, opinion, appeal, advice), motives, objectives and circumstances of resorting to the transmissions (why in what situation). The project will result in: 1) educational rapprochement of cultures, 2) breaking down of stereotypes, 3) preparation of professional teacher training standards in establishing a culture of trust in the use of digital media.