The University of Sydney is a public university located in Sydney, New South Wales. The main campus spreads across the suburbs of Camperdown and Darlington on the southwestern outskirts of the Sydney CBD. Founded in 1850, it is the oldest university in Australia and Oceania. It has 32,393 undergraduate and 16,627 graduate students . The University of Sydney is organised into sixteen faculties and schools, through which it offers bachelor's degrees, master's degrees, and doctoral degrees. Wikipedia.
University of Sydney and Northern Sydney Local Health District | Date: 2017-03-22
The present invention relates to a method for detecting cardiovascular oxidative stress in an individual, comprising detecting in a blood sample from the individual modification of a cysteine at position 45 of the 1-subunit of the human erythrocyte ATP-dependent Na^(+)K^(+ )pump protein or of an equivalent cysteine in a homologue or variant thereof. The invention further relates to a kit for detecting cardiovascular oxidative stress in an individual, the kit comprising at least one agent for detecting the presence of a modification in a cysteine at position 45 of the 1-subunit of the human erythrocyte ATP-dependent Na^(+)K^(+ )pump protein or of an equivalent cysteine in a homologue or variant thereof, wherein said modification is a result of oxidation.
University of Sydney | Date: 2017-01-18
University of Sydney and University of Technology, Sydney | Date: 2017-03-29
The present invention relates to new omega-3 fatty acid analogues and to their use in cancer therapy, including anti-metastatic therapy.
University of Sydney | Date: 2017-05-31
A method of adaptive suppression of over-smoothing in noise/artefact reduction techniques such as total variation minimization or other compressed sensing strategies for Cone Beam Computed Tomography (CBCT) images, the method including the steps of: (a) inputting a CBCT image; (b) identifying the anatomical structures of interest in the CBCT images by exploiting their likely shapes, attenuation coefficients, sizes, positions, or any other similar features that can be used to identify them from an image; (c) extracting intensity, gradient, or other image-related information of the identified anatomical structures from the CBCT image; (d) adaptively suppressing over-smoothing in noise/artefact reduction techniques such as total-variation minimization or other compressed sensing strategies at the anatomical structures of interest using the information of the anatomical structures extracted previously.
University of Sydney | Date: 2015-03-12
Salk Institute for Biological Studies and University of Sydney | Date: 2016-09-12
Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.
University of Sydney and Centenary Institute Of Cancer Medicine And Cell Biology | Date: 2017-02-28
The invention relates to the identification of antigens, including Mycobacterium sulphate assimilation pathway components such as CysD, for preventing and treating Mycobacterium infection, especially but not exclusively Mycobacterium tuberculosis infection; to expression systems including live Mycobacterium for expression of said antigens for prevention and treatment of said infection; and to use of said antigens and expression systems for prevention and treatment of said infection.
University of Sydney | Date: 2017-01-18
Systems and methods for identifying tumors having activated progesterone receptors are provided. Patients suspected of having a tumor susceptible to growth inhibition by anti-progestins can be treated with an anti-progestin.
Baxter R.C.,University of Sydney
Nature Reviews Cancer | Year: 2014
The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs) were originally characterized as passive reservoirs of circulating IGFs, but they are now understood to have many actions beyond their endocrine role in IGF transport. IGFBPs also function in the pericellular and intracellular compartments to regulate cell growth and survival-they interact with many proteins, in addition to their canonical ligands IGF-I and IGF-II. Intranuclear roles of IGFBPs in transcriptional regulation, induction of apoptosis and DNA damage repair point to their intimate involvement in tumour development, progression and resistance to treatment. Tissue or circulating IGFBPs might also be useful as prognostic biomarkers. © 2014 Macmillan Publishers Limited.
Jackson S.D.,University of Sydney
Nature Photonics | Year: 2012
The diverse output pulsewidths, linewidths and polarization states of fibre lasers provide both high efficiency and high output power in a small, low-maintenance format that is ideal for applications throughout research, defence and industry. New directions are constantly being pursued to exploit the capabilities of this technology. One such direction involves extending the emission wavelength further into the infrared, which will benefit numerous existing and future applications. Many exciting advances have been demonstrated and many challenges remain, the most significant of which are summarized in this Review. © 2012 Macmillan Publishers Limited. All rights reserved.