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Manis Subang, Indonesia

Mousa A.,McGill University | Mousa A.,University of Subang
Arabian Journal of Geosciences | Year: 2016

The presence of silt-size particles is believed to be one of the chief factors behind the sketchy behavior of transitional soils. Although some studies have investigated reconstituted and local silty soils on many fronts, the disproportionate understanding of the effect of the “hybrid” fabric and structure has long stood against adequate characterization of silty soils. Supported by preliminary results, this study conceptually portrays a relationship between silt’s fabric and plasticity of natural transitional soils. Close examination of scanning electron microscopy (SEM) on a few selected silty soils demonstrates their transitional particulate structure. Patterns and coverage of clay coatings qualitatively support the noted transition in the structure and consistency. The use of mean size (D50-silt) and the mean weight diameter (MWDsilt) of the silt fraction, along with the fabric observed in micrographs, indicates a negative correlation between the coarseness of the silt-size particles and soil’s consistency. These preliminary observations further support the importance of understanding the role of silt’s fabric in transitional behavior. © 2015, Saudi Society for Geosciences. Source

Kumarappan C.,University of Subang | Mandal S.C.,Jadavpur University
International Journal of Diabetes in Developing Countries | Year: 2015

The leaves of Ichnocarpus frutescens (L). Br. (Apocynaceae) are used extensively in the form of decoction in Ayurveda for treating diabetes. The objective of this investigation was taken to ascertain the scientific basis for the use of I. frutescens in the management of diabetes, using streptozotocin-induced type II diabetic rats. The total polyphenol extract of the plant leaf was tested for its oral glucose tolerance test (OGTT) antidiabetic efficacy for 30 days on carbohydrate metabolism in streptozotocin-induced diabetic rats. In OGTT, at 60 min, the maximum decrease of blood glucose was observed with 200 mg/kg of polyphenolic extracts (PPE). Oral administration of I. frutescens leaves PPE in graded doses caused a significantly lowered fasting blood glucose levels and lipid profiles in the liver of type II diabetic rats. Effects of PPE on glycolytic enzymes showed a significant increase in their levels, whereas a significant decrease was observed in the levels of gluconeogenic enzyme in treated diabetic rats. The present investigation suggests that the antihyperglycemic effect of PPE of leaves of I. frutescens is mediated through modulation of hepatic carbohydrate-metabolizing enzymes in streptozotocin-induced type II diabetic rats. It also explains the basis for its traditional use by tribal community of southern India. © 2015, Research Society for Study of Diabetes in India. Source

Kumarappan C.,University of Subang | Mandal S.C.,Jadavpur University
Indian Journal of Physiology and Pharmacology | Year: 2014

Introduction: The leaves of Ichnocarpus frutescens are used extensively as a decoction for the treatment of diabetes mellitus by the tribals of Karnataka and Uttar Pradesh states.Methods: Anti-diabetic activity of polyphenol extract of Ichnocarpus frutescens was investigated using dexamethasone (DEX) induced hyperglycemia in Wistar rats. Experimental animals were injected subcutaneously with dexamethasone 3 mg/kg/day. After one week, hyperglycemic rats were orally treated with polyphenol extract (PPE) extracts at the dose of 300 mg/kg/day and 150 mg/kg/day for a period of 14 days.Results: Administration of DEX to fasted rats for 21 days resulted in insulin resistance evidenced by the significant increase in mean fasting blood glucose level (162.33±4.72 mg/dl). Both 300 mg/kg and 150 mg/ kg of PPE markedly reversed DEX induced mean fasting blood glucose level to 104.00±3.30 mg/dl and 145.5±1.99 mg/dl, respectively when compared with the positive control (p<0.01).Conclusion: The possible mechanism by which polyphenol extract of I. frutescens brings about its antihyperglycemic action might be through potentiation of insulin sensitivity enhanced transport of blood glucose to the peripheral tissues. However, these findings suggest that polyphenol extract of I. frutescens therapy may reduce the risk of dexamethasone induced hyperglycemia in Wistar rats. These observations suggest that I. frutescens is a potential glucose lowering agent to ameliorate glucocorticoids induced hyperglycemia. © 2014, Association of Physiologists and Pharmacologists of India. All rights reserved. Source

Sukumaran S.,University of Subang | Chandran K.,Sunway University
Lecture Notes in Business Information Processing | Year: 2015

This conceptual paper sheds light on how analysts deal with the issue of unspoken or unconscious requirements that users might have with regards to Knowledge Management Systems (KMS). Current approaches to requirements elicitation of KMS tend to concentrate mainly on technical aspects, but they ignore human and social influences. How do analysts recognize requirements that users don’t or can’t tell them about? What approaches have been used and are there (if any) methods that have specifically been developed to identify such requirements? Are KM researchers and practitioners in the area of requirements elicitation aware of the ongoing research in the social and behavioural fields? The paper sheds light on how to improve the way analysts currently obtain requirements from stakeholders. These proposed Knowledge Management – Requirement Elicitation (KMRE) framework is a resource to elicit requirements regarding the human context of a system using a set of analytical techniques and knowledge from Activity Theory and Co-creation. The framework enables collaborative work between requirements engineers, who gather these inputs in the form of software requirements, social practitioners, who provide the knowledge and processes underlying these tools, and the stakeholders, who know the domain and intended application of the projects. © Springer International Publishing Switzerland 2015. Source

Peh S.C.W.,University of Subang | Hong J.L.,University of Subang
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

The guided local search method has been successfully applied to a significant number of NP-hard optimization problems, producing results of similar caliber, if not better, compared to those obtained from algorithms specially designed for each singular optimization problem. Ranging from the familiar TSP and QAP to general function optimization problems, GLS sits atop many well-known algorithms such as Genetic Algorithm (GA), Simulated Annealing (SA) and Tabu Search (TS). With lesser parameters to adjust to, GLS is relatively simple to implement and apply in many problems. This paper focuses on the potential applications of GLS in ligand docking problems via drug design. Over the years, computer aided drug design (CADD) has spearheaded the drug design process, whereby much focus has been trained on efficient searching in de novo drug design. Previous and ongoing approaches of meta heuristic methods such as GA, SA & TS have proven feasible, but not without problems. Inspired by the huge success of Guided Local Search (GLS) in solving optimization problems, we incorporated it into the drug design problem in protein ligand docking and have found it to be effective. © Springer International Publishing Switzerland 2016. Source

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