Manis Subang, Indonesia

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Manis Subang, Indonesia

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Kumarappan C.,University of Subang | Mandal S.C.,Jadavpur University
Indian Journal of Physiology and Pharmacology | Year: 2014

Introduction: The leaves of Ichnocarpus frutescens are used extensively as a decoction for the treatment of diabetes mellitus by the tribals of Karnataka and Uttar Pradesh states.Methods: Anti-diabetic activity of polyphenol extract of Ichnocarpus frutescens was investigated using dexamethasone (DEX) induced hyperglycemia in Wistar rats. Experimental animals were injected subcutaneously with dexamethasone 3 mg/kg/day. After one week, hyperglycemic rats were orally treated with polyphenol extract (PPE) extracts at the dose of 300 mg/kg/day and 150 mg/kg/day for a period of 14 days.Results: Administration of DEX to fasted rats for 21 days resulted in insulin resistance evidenced by the significant increase in mean fasting blood glucose level (162.33±4.72 mg/dl). Both 300 mg/kg and 150 mg/ kg of PPE markedly reversed DEX induced mean fasting blood glucose level to 104.00±3.30 mg/dl and 145.5±1.99 mg/dl, respectively when compared with the positive control (p<0.01).Conclusion: The possible mechanism by which polyphenol extract of I. frutescens brings about its antihyperglycemic action might be through potentiation of insulin sensitivity enhanced transport of blood glucose to the peripheral tissues. However, these findings suggest that polyphenol extract of I. frutescens therapy may reduce the risk of dexamethasone induced hyperglycemia in Wistar rats. These observations suggest that I. frutescens is a potential glucose lowering agent to ameliorate glucocorticoids induced hyperglycemia. © 2014, Association of Physiologists and Pharmacologists of India. All rights reserved.


Mousa A.,McGill University | Mousa A.,University of Subang
Arabian Journal of Geosciences | Year: 2016

The presence of silt-size particles is believed to be one of the chief factors behind the sketchy behavior of transitional soils. Although some studies have investigated reconstituted and local silty soils on many fronts, the disproportionate understanding of the effect of the “hybrid” fabric and structure has long stood against adequate characterization of silty soils. Supported by preliminary results, this study conceptually portrays a relationship between silt’s fabric and plasticity of natural transitional soils. Close examination of scanning electron microscopy (SEM) on a few selected silty soils demonstrates their transitional particulate structure. Patterns and coverage of clay coatings qualitatively support the noted transition in the structure and consistency. The use of mean size (D50-silt) and the mean weight diameter (MWDsilt) of the silt fraction, along with the fabric observed in micrographs, indicates a negative correlation between the coarseness of the silt-size particles and soil’s consistency. These preliminary observations further support the importance of understanding the role of silt’s fabric in transitional behavior. © 2015, Saudi Society for Geosciences.


Yatawatte H.,University of Colombo | Dharmaratne A.,University of Subang
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2015

With the advancement in networking, content produced and distributed over the Internet is exponentially increasing. This imposes the threat of distribution of obscene content freely and largely, urging mechanisms to control access by minor aged users. Manual retrieval and indexing of material is impossible for large video repositories. This paper proposes a method to detect videos with obscene adult content using content based video retrieval techniques. We propose an algorithm to summarize the video by extracting keyframes that mark video shot boundaries and apply BoVW algorithm to classify keyframes indicating the presence of obscenity. Despite the ignorance of high-level features in temporal domain, a higher recognition rate of 85% with spatial information alone is proved. Further, we show the irrelevance of color information to detect nudity in videos when using BoVW. © Springer International Publishing Switzerland 2015.


Karunatilaka D.,University of Subang | Kalavally V.,University of Subang | Parthiban R.,University of Subang
IEEE Photonics Technology Letters | Year: 2016

Wavelength division multiplexing (WDM) systems in visible light communication are able to increase the data rates by independently modulating colored light sources-generally red, green, and blue. We analytically model such a system using orthogonal frequency division multiplexing modulation and show that the main limitation in achieving higher capacity and illuminance is the red channel. We propose alternate WDM techniques-one which uses an additional red light emitting diode (LED) to offset this effect and another which uses an unmodulated amber LED. By evaluating these systems, we show that increased capacity, higher illuminance range, as well as superior light quality could be achieved by the latter. © 2016 IEEE.


Peh S.C.W.,University of Subang | Hong J.L.,University of Subang
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

The guided local search method has been successfully applied to a significant number of NP-hard optimization problems, producing results of similar caliber, if not better, compared to those obtained from algorithms specially designed for each singular optimization problem. Ranging from the familiar TSP and QAP to general function optimization problems, GLS sits atop many well-known algorithms such as Genetic Algorithm (GA), Simulated Annealing (SA) and Tabu Search (TS). With lesser parameters to adjust to, GLS is relatively simple to implement and apply in many problems. This paper focuses on the potential applications of GLS in ligand docking problems via drug design. Over the years, computer aided drug design (CADD) has spearheaded the drug design process, whereby much focus has been trained on efficient searching in de novo drug design. Previous and ongoing approaches of meta heuristic methods such as GA, SA & TS have proven feasible, but not without problems. Inspired by the huge success of Guided Local Search (GLS) in solving optimization problems, we incorporated it into the drug design problem in protein ligand docking and have found it to be effective. © Springer International Publishing Switzerland 2016.


Peh S.C.W.,University of Subang | Hong J.L.,University of Subang
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

The bacterial foraging optimization (BFO) method has been successfully applied in a number of optimization problems, especially alongside Particle Swarm Optimization as hybrid combinations. This relatively recent method is based on the locomotion and behavior of bacteria E.coli, with modifications made over the years to increase search time, space and reduce convergence time. Regardless of changes, BFO algorithms are still based on 4 main features which are Chemotaxis, reproduction, swarming, elimination and dispersal behaviours of E.coli. A nature based algorithm, BFO has been utilized in several optimization problems such as the power loss reduction problem and in the area of PID applications. Ligand docking is another optimization problem that can potentially benefit from BFO application and this paper will focus on the methodology of BFO application and its results. We are of the opinion that the incorporation of BFO in the ligand docking problem is effective and efficient. © Springer International Publishing Switzerland 2016.


Peh S.C.W.,University of Subang | Hong J.L.,University of Subang
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

Molecular docking is an essential topic of study as it is crucial in numerous biological processes such as signal transduction and gene expression. Computational efforts to predict ligand docking is preferable to costly x-ray crystallography and Nuclear Magnetic Resonance (NMR) yet technology today remains incompetent in exploring vast search spaces for optimal solutions. To create efficient and effective algorithms, research has led to De novo drug design: a technique to extract novel chemical structures from protein banks is largely evolutionary in nature, and has found measurable success in optimal solution searching. A study by Shara Amin in 1999 in her novel method: simulated jumping (SJ) has achieved promising results when tested on combinatorial optimization problems such as the Quadratic Assignment and Asymmetric Travelling Salesman problems. Following her success with SJ, we aim to incorporate SJ into protein ligand docking, another optimization problem. © Springer International Publishing Switzerland 2016.


Ghritas are Ayurvedic lipid based preparations in which oil or ghee is boiled with prescribed kasaya (decoction) and kalkas (fine paste) of drugs until the evaporation of aqueous phase transfers the contents into oily phase. The polyherbal decoction (kasaya) used in the preparation predominantly contains water soluble Active Botanical Ingredients (ABIs). Guggulu tiktaka ghrita (GTG) was taken as model ghrita for this study. The analysis of ghrita was affected by the contents of the ghee which interfered in the determination and estimation of ABIs in the formulation. Thus, it was important to remove those interferences before the chromatographic analysis by techniques like TLC, HPTLC, HPLC and GC. Solid phase extraction (SPE) was performed to remove the interferences followed by HPTLC and GCMS analysis. The results have shown that the interferences were completely removed by solid phase extraction which facilitates the determination of ABIs by other chromatographic techniques. © 2015, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.


Kee E.X.Y.,University of Subang | Hong J.L.,University of Subang
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2015

The growth of social media over the past years has revolutionized the interaction between individuals as well as the business conduct of many industries. In contest for extraction of the valuable insights available, the dynamic nature of the social media data is seen to be a challenging factor. With many tools available in the market today, the ultimate solution is yet to suffice the needs of businesses today. Therefore, the concept and approach of a heuristic data mining framework is to be proposed in overcoming this task. By having a robust framework of which is proven to conduct the dynamic data mining, the essence sustained within social media of which industries are looking for will be extracted to achieve greater milestones. © Springer International Publishing Switzerland 2015.


Toh H.J.,University of Subang | Hong J.L.,University of Subang
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2014

Webpage segmentation is a non trivial task and is a promising research area in the field of computing study. Webpage segments demarcate informative and non-informative content in a webpage through the extraction of text and image. Not only that, segments can also distinguish different types of information between segments. Webpage segmentation is certainly useful in web ranking, classification, and other web mining applications. Segments identification is also useful in page display for constraint limited screen devices such as smart phones, PDAs etc. Recent research focused on using ontology tool to segment a webpage. However, this tool only supports English language. In this paper, we propose a multilingual ontology tool for segmenting webpage. Our tool has shown higher accuracy than existing methods for webpage segmentation. © Springer International Publishing Switzerland 2014.

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