Manis Subang, Indonesia

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Lai Y.K.,UCSI University | Lai N.M.,University of Subang | Lee S.W.H.,Monash University
Annals of Hematology | Year: 2017

Emerging epidemiological evidence suggests that patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency may have a higher risk of developing diabetes. The aim of the review was to synthesise the evidence on the association between G6PD deficiency and diabetes. A systematic search on Medline, EMBASE, AMED and CENTRAL databases for studies published between January 1966 and September 2016 that assessed the association between G6PD deficiency and diabetes was conducted. This was supplemented by a review of the reference list of retrieved articles. We extracted data on study characteristics, outcomes and performed an assessment on the methodological quality of the studies. A random-effects model was used to compute the summary risk estimates. Fifteen relevant publications involving 949,260 participants were identified, from which seven studies contributed to the meta-analysis. G6PD deficiency was associated with a higher odd of diabetes (odds ratio 2.37, 95% confidence interval 1.50–3.73). The odds ratio of diabetes among men was higher (2.22, 1.31–3.75) compared to women (1.87, 1.12–3.12). This association was broadly consistent in the sensitivity analysis. Current evidence suggests that G6PD deficiency may be a risk factor for diabetes, with higher odds among men compared to women. Further research is needed to determine how G6PD deficiency moderates diabetes. © 2017 Springer-Verlag Berlin Heidelberg


Liang O.A.,National University of Malaysia | Subramaniam P.,National University of Malaysia | Paraidathathu T.,University of Subang
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2015

Objectives: The Malaysian Pharmaceutical Society (MPS) is the professional association for pharmacists in Malaysia. It plays a significant role in the continuous education of pharmacists by serving as a platform to inform members of the latest developments in pharmacy, to further stimulate interest and collaboration in research and also to uphold and enhance the standards and ethics of the profession. Unfortunately, like many professional associations, the goals of the MPS are hindered by its low membership rate. The objective of this study was to determine the membership rate, perception and knowledge of the MPS among recently licensed pharmacists. Methods: A voluntary survey was conducted, using a questionnaire, among pharmacists who were recently licensed and in the process of completing their compulsory service. The total number of respondents was 175. Results: Ninety-five percent of those surveyed felt that a professional association was important for the future of pharmacists, yet only 50% were MPS members. More than 85% of respondents were women and most of them (54.3%) were graduates from private universities. The majority of those who were not members of MPS indicated that they did not join MPS because they were unaware of the benefits of membership or lacked time for MPS activities. This is likely a contributing factor to low rates of membership observed among professional pharmaceutical associations worldwide. Conclusion: Accordingly, we believe that greater effort by MPS, and similar professional bodies, to improve awareness of the association and benefits of membership would increase membership and the long-term will benefit the pharmacy profession. © 2015, International Journal of Pharmacy and Pharmaceutical Sciences. All Rights Reserved.


Wong P.P.W.,University of Subang
Anatolia | Year: 2017

As competition among tourist destinations in the region to attract more tourists is becoming more intense, it is essential for destinations in Malaysia to identify and evaluate their competitive attributes to enable our different industry stakeholders to manage and maintain the destinations’ tourism resources more effectively. To evaluate our destinations’ competitiveness, it is necessary to look at the elements of both the comparative and competitive advantage of the destinations. This study seeks to evaluate the different competitiveness attributes of selected urban destinations in Malaysia and to examine the relationship between those attributes and destination loyalty. Results from a regression analysis confirmed the hypothesized relationships between the competitiveness attributes on destination loyalty. © 2017 Informa UK Limited, trading as Taylor & Francis Group.


Mura P.,University of Subang | Sharif S.P.,University of Subang
Journal of Tourism and Cultural Change | Year: 2017

While previous tourism studies on the visual have tended to focus on the analysis of photos, only recently videos have received more attention by tourism scholars. Within the emerging tourism literature on videos, little has been written on the videos produced and shared by online news and documentary networks and their persuasive effects on potential tourists’ perceptions about a destination. By focusing on Iran, this work investigates whether videos produced and shared by online news and documentary networks influence viewers’ perceptions about the country and their willingness to travel to the country. This study employs semi-structured, in-depth interviews to explore the meanings and interpretations attached to two videos about Iran, which were produced and shared by an Iranian online news and documentary network. A total of 15 participants, including a film producer and 14 respondents as audience were interviewed. Overall, the findings of this study highlight that the videos’ interpretations by the participants were multiple and often diverged from the producer’s intentions. Moreover, although the videos were perceived as tools produced to attract tourists, they were not regarded as sufficiently persuasive to totally change previously formed images about Iran and create a strong desire to visit the country. © 2017 Informa UK Limited, trading as Taylor & Francis Group


Esmaeilzadeh P.,Florida International University | Sambasivan M.,University of Subang
BMC Medical Informatics and Decision Making | Year: 2017

Background: Literature indicates that one of the most important factors affecting the widespread adoption of Health Information Exchange (HIE) is patient support and endorsement. In order to reap all the expected benefits of HIE, patients’ acceptance of technology is a challenge that is not fully studied. There are a few studies which have focused on requirements of electronic medical information exchange from consumers’ views and expectations. This study is aimed at reviewing the literature to articulate factors that affect patients to support HIE efforts. Methods: A literature review of current studies addressing patients’ views on HIE from 2005 was undertaken. Five electronic research databases (Science Direct, PubMed, Web of Science, CINAHL, and Academic Search Premiere) were searched to retrieve articles reporting pros and cons of HIE from patients’ opinion. Results: One hundred and ninety six articles were initially retrieved from the databases. Out of 196, 36 studies met the inclusion criteria and were fully reviewed. Our findings indicate that patient’s attitude toward HIE is affected by seven main factors: perceived benefits, perceived concerns, patient characteristics, patient participation level in HIE, type of health information, identity of recipients, and patient preferences regarding consent and features. Conclusions: The findings provide useful theoretical implications for research by developing a classification of significant factors and a framework based on the lessons learned from the literature to help guide HIE efforts. Our results also have fundamental practical implications for policy makers, current and potential organizers of HIEs by highlighting the role of patients in the widespread implementation of HIE. The study indicates that new approaches should be applied to completely underline HIE benefits for patients and also address their concerns. © 2017 The Author(s).


Mousa A.,University of Subang
International Journal of Geomechanics | Year: 2017

Conventional laboratory tests in geomechanics are inherently designed to create a uniform stress-strain field whereby relative homogeneity in data prevails at the expense of information diversity. The one-element convenience using stress homogeneity lends itself well to constitutive model calibration. From a mathematical standpoint, this approach potentially promotes uncertainty and error propagation. More recently, there has been a growing effort to utilize all data of conventional tests, including the effect of end restraints, to improve model calibration. This conceptual study revisits the notion of constitutive model calibration holding the perspective of inverse problems. For calibration purposes, nonconventional loading and complex boundary conditions were deemed to create a rich (nonuniform) strain-stress field. In this study, flexure excitation was investigated as a plausible test configuration in experimental geomechanics. An attempt was made to gauge the merits of flexural loading of a cylindrical soil specimen in providing independent data (information-rich test). The proposed test configuration was experimentally conducted and numerically optimized for assessment of model calibration. © 2017 American Society of Civil Engineers.


Kumarappan C.,University of Subang | Mandal S.C.,Jadavpur University
Indian Journal of Physiology and Pharmacology | Year: 2014

Introduction: The leaves of Ichnocarpus frutescens are used extensively as a decoction for the treatment of diabetes mellitus by the tribals of Karnataka and Uttar Pradesh states.Methods: Anti-diabetic activity of polyphenol extract of Ichnocarpus frutescens was investigated using dexamethasone (DEX) induced hyperglycemia in Wistar rats. Experimental animals were injected subcutaneously with dexamethasone 3 mg/kg/day. After one week, hyperglycemic rats were orally treated with polyphenol extract (PPE) extracts at the dose of 300 mg/kg/day and 150 mg/kg/day for a period of 14 days.Results: Administration of DEX to fasted rats for 21 days resulted in insulin resistance evidenced by the significant increase in mean fasting blood glucose level (162.33±4.72 mg/dl). Both 300 mg/kg and 150 mg/ kg of PPE markedly reversed DEX induced mean fasting blood glucose level to 104.00±3.30 mg/dl and 145.5±1.99 mg/dl, respectively when compared with the positive control (p<0.01).Conclusion: The possible mechanism by which polyphenol extract of I. frutescens brings about its antihyperglycemic action might be through potentiation of insulin sensitivity enhanced transport of blood glucose to the peripheral tissues. However, these findings suggest that polyphenol extract of I. frutescens therapy may reduce the risk of dexamethasone induced hyperglycemia in Wistar rats. These observations suggest that I. frutescens is a potential glucose lowering agent to ameliorate glucocorticoids induced hyperglycemia. © 2014, Association of Physiologists and Pharmacologists of India. All rights reserved.


Peh S.C.W.,University of Subang | Hong J.L.,University of Subang
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

The guided local search method has been successfully applied to a significant number of NP-hard optimization problems, producing results of similar caliber, if not better, compared to those obtained from algorithms specially designed for each singular optimization problem. Ranging from the familiar TSP and QAP to general function optimization problems, GLS sits atop many well-known algorithms such as Genetic Algorithm (GA), Simulated Annealing (SA) and Tabu Search (TS). With lesser parameters to adjust to, GLS is relatively simple to implement and apply in many problems. This paper focuses on the potential applications of GLS in ligand docking problems via drug design. Over the years, computer aided drug design (CADD) has spearheaded the drug design process, whereby much focus has been trained on efficient searching in de novo drug design. Previous and ongoing approaches of meta heuristic methods such as GA, SA & TS have proven feasible, but not without problems. Inspired by the huge success of Guided Local Search (GLS) in solving optimization problems, we incorporated it into the drug design problem in protein ligand docking and have found it to be effective. © Springer International Publishing Switzerland 2016.


Peh S.C.W.,University of Subang | Hong J.L.,University of Subang
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

The bacterial foraging optimization (BFO) method has been successfully applied in a number of optimization problems, especially alongside Particle Swarm Optimization as hybrid combinations. This relatively recent method is based on the locomotion and behavior of bacteria E.coli, with modifications made over the years to increase search time, space and reduce convergence time. Regardless of changes, BFO algorithms are still based on 4 main features which are Chemotaxis, reproduction, swarming, elimination and dispersal behaviours of E.coli. A nature based algorithm, BFO has been utilized in several optimization problems such as the power loss reduction problem and in the area of PID applications. Ligand docking is another optimization problem that can potentially benefit from BFO application and this paper will focus on the methodology of BFO application and its results. We are of the opinion that the incorporation of BFO in the ligand docking problem is effective and efficient. © Springer International Publishing Switzerland 2016.


Peh S.C.W.,University of Subang | Hong J.L.,University of Subang
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

Molecular docking is an essential topic of study as it is crucial in numerous biological processes such as signal transduction and gene expression. Computational efforts to predict ligand docking is preferable to costly x-ray crystallography and Nuclear Magnetic Resonance (NMR) yet technology today remains incompetent in exploring vast search spaces for optimal solutions. To create efficient and effective algorithms, research has led to De novo drug design: a technique to extract novel chemical structures from protein banks is largely evolutionary in nature, and has found measurable success in optimal solution searching. A study by Shara Amin in 1999 in her novel method: simulated jumping (SJ) has achieved promising results when tested on combinatorial optimization problems such as the Quadratic Assignment and Asymmetric Travelling Salesman problems. Following her success with SJ, we aim to incorporate SJ into protein ligand docking, another optimization problem. © Springer International Publishing Switzerland 2016.

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