University of Southern Denmark

www.sdu.dk
Odense, Denmark

The University of Southern Denmark, with campuses located in Funen, Southern Jutland and Zealand - is a research and educational institution with deep regional roots and an international outlook. Reaching even further south, the university offers a number of joint programmes in co-operation with the University of Flensburg and the University of Kiel. Contacts with regional industries and the international scientific community are strong. Wikipedia.

SEARCH FILTERS
Time filter
Source Type

Patent
University of Southern Denmark and Region Syddanmark | Date: 2015-06-19

A method is provided for treating or ameliorating a high-grade glioma in a patient, which method comprises intracerebral administering of a radioactive agent characterized by a short-range cytotoxic ionizing radiation by convection-enhanced delivery. Further, a radioactive agent characterized by a short-range cytotoxic ionizing radiation is provided for use in treating or ameliorating a high-grade glioma, where the agent is administered by intracerebral convection-enhanced delivery


Patent
University of Southern Denmark and Region Syddanmark | Date: 2017-04-26

A method is provided for treating or ameliorating a high-grade glioma in a patient, which method comprises intracerebral administering of a radioactive agent characterized by a short-range cytotoxic ionizing radiation by convection-enhanced delivery. Further, a radioactive agent characterized by a short-range cytotoxic ionizing radiation is provided for use in treating or ameliorating a high-grade glioma, where the agent is administered by intracerebral convection-enhanced delivery


Patent
Rigshospitalet, Copenhagen University and University of Southern Denmark | Date: 2017-01-06

The present invention relates to novel chimeric molecules of ficolin-associated polypeptides, such as fusion polypeptides for the use in the treatment of conditions associated with inflammation, apoptosis, autoimmunity, coagulation, thrombotic or coagulopathic related diseases. The present invention further relates to nucleic acid molecules encoding such fusion polypeptides, vectors and host cells used in the production of the fusion polypeptides.


Patent
University of Southern Denmark and University of Aarhus | Date: 2017-04-12

The present invention relates to glycosylated YghJ polypeptides from or derived from enterotoxigenic Escherichia coli (ETEC) that are immunogenic. In particular, the present invention relates to compositions or vaccines comprising the polypeptides and their application in immunization, vaccination, treatment and diagnosis of ETEC.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-21-2016 | Award Amount: 7.07M | Year: 2017

ImpleMentAll will develop, apply, and evaluate tailored implementation strategies in the context of on-going eHealth implementation initiatives in the EU and beyond. Common mental health disorders account for an alarming proportion of the global burden of disease. Being regarded as an evidence-based psychotherapeutic eHealth intervention, Internet-based Cognitive Behavioural Therapy (iCBT), has the potential to answer to this societal challenge by providing an efficacious and efficient treatment from which more people can benefit. As a result, various iCBT implementation projects are currently conducted across the world. We propose to use this natural laboratory to develop and evaluate a toolkit for tailored implementation strategies that is expected to make implementation trajectories more efficient. The objectives for ImpleMentAll are: 1) To develop a generic Integrated Theory-based Framework for Intervention Tailoring Strategies (the ItFits-toolkit) for data-driven tailored implementation of evidence-based eHealth services. 2) To demonstrate the impact of the ItFits toolkit on the implementation of eHealth for common mental disorders, in 9 European countries, 2 LMIC, and Australia. 3) To disseminate the validated toolkit in various healthcare contexts across Europe. ImpleMentAll is a true multidisciplinary international collaboration that unites key experts in clinical practice, health innovation, clinical research, and implementation science. Combined with its unique setup, ImpleMentAll will be able to test if tailoring implementation strategies lead to more efficient implementation. The resulting ItFits-toolkit will enable data driven evaluation of eHealth implementation projects in terms key performance indicators for process, effectiveness, and efficiency outcomes. Its methods, materials, and strategies will provide concrete guidance on tuning implementation interventions to local determinant of practice across a variety of health care systems.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-01-2016 | Award Amount: 16.02M | Year: 2017

The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC, ICGC, TwinsUK and Meta-HIT) to investigate human data sets on three major levels of resolution: whole blood signatures, signatures from purified immune cell types (with a focus on CD14 and CD4/CD8) and selected single cell level analyses. Principle data layers will comprise SNP variome, methylome, transcriptome and gut microbiome. SYSCID employs a dedicated data management infrastructure, strong algorithmic development groups (including an SME for exploitation of innovative software tools for data deconvolution) and will validate results in independent retrospective and prospective clinical cohorts. Using this setup we will focus on three fundamental aims : (i) the identification of shared and unique core disease signatures which are associated with the disease state and independent of temporal variation, (ii) the generation of predictive models of disease outcome- builds on previous work that pathways/biomarkers for disease outcome are distinct from initial disease risk and may be shared across diseases to guide therapy decisions on an individual patient basis, (iii) reprogramming disease - will identify and target temporally stable epigenetic alterations in macrophages and lymphocytes in epigenome editing approaches as biological validation and potential novel therapeutic tool. Thus, SYSCID will foster the development of solid biomarkers and models as stratification in future long-term systems medicine clinical trials but also investigate new causative therapies by editing the epigenome code in specific immune cells, e.g. to alleviate macrophage polarization defects.


Kouvaris C.,University of Southern Denmark
Physical Review Letters | Year: 2012

We impose new severe constraints on the self-interactions of fermionic asymmetric dark matter based on observations of nearby old neutron stars. Weakly interacting massive particle (WIMP) self-interactions mediated by Yukawa-type interactions can lower significantly the number of WIMPs necessary for gravitational collapse of the WIMP population accumulated in a neutron star. Even nearby neutron stars located at regions of low dark matter density can accrete a sufficient number of WIMPs that can potentially collapse, form a mini black hole, and destroy the host star. Based on this, we derive constraints on the WIMP self-interactions which in some cases are by several orders of magnitude stricter than the ones from the bullet cluster. © 2012 American Physical Society.


Thamdrup B.,University of Southern Denmark
Annual Review of Ecology, Evolution, and Systematics | Year: 2012

Our understanding of the players and pathways of the global nitrogen cycle has advanced substantially over recent years with discoveries of several new groups of organisms and new types of metabolism. This review focuses on recently discovered processes that add new functionality to the nitrogen cycle and on the organisms that perform these functions. The processes include denitrification and other dissimilatory nitrogen transformations in eukaryotes, anaerobic ammonium oxidation, and anaerobic methane oxidation with nitrite. Of these, anaerobic ammonium oxidation coupled to nitrite reduction by anammox bacteria has been well documented in natural environments and constitutes an important sink for fixed nitrogen. Benthic foraminifera also contribute substantially to denitrification in some sediments, in what potentially represents an ancestral eukaryotic metabolism. The ecophysiology of the novel organisms and their interactions with classical types of nitrogen metabolism are important for understanding the nitrogen cycle and its tight links to the cycling of carbon today, in the past, and in the future. © 2012 by Annual Reviews. All rights reserved.


Han Z.,University of Southern Denmark
Reports on progress in physics. Physical Society (Great Britain) | Year: 2013

Surface plasmon polaritons (SPPs) are electromagnetic (EM) modes propagating along metal-dielectric interfaces, in which surface collective excitations of free electrons in the metal are coupled to evanescent EM fields in the dielectric. Various SPP modes can be supported by flat and curved, single and multiple surfaces, exhibiting remarkable properties, including the possibility of concentrating EM fields beyond the diffraction limit, i.e. on the nanoscale, while enhancing local field strengths by several orders of magnitude. This unique feature of SPP modes, along with the ever-increasing demands for miniaturization of photonic components and circuits, generates an exponentially growing interest in SPP-mediated radiation guiding and SPP-based waveguide components. Here we review the current status of this rapidly developing field, starting with a brief presentation of the main planar SPP modes along with the techniques employed for their excitation and manipulation by sets of nanoparticles. We then describe in detail various SPP-based waveguide configurations that ensure two-dimensional mode confinement in the plane perpendicular to the propagation direction and compare their characteristics. Excitation of SPP waveguide modes and recent progress in the development of SPP-based waveguide components are also discussed, concluding with our outlook on challenges and possible future developments in this field.


Placenta has a wide range of functions. Some are supported by novel genes that have evolved following gene duplication events while others require acquisition of gene expression by the trophoblast. Although not expressed in the placenta, high-affinity fetal hemoglobins play a key role in placental gas exchange. They evolved following duplications within the beta-globin gene family with convergent evolution occurring in ruminants and primates. In primates there was also an interesting rearrangement of a cassette of genes in relation to an upstream locus control region. Substrate transfer from mother to fetus is maintained by expression of classic sugar and amino acid transporters at the trophoblast microvillous and basal membranes. In contrast, placental peptide hormones have arisen largely by gene duplication, yielding for example chorionic gonadotropins from the luteinizing hormone gene and placental lactogens from the growth hormone and prolactin genes. There has been a remarkable degree of convergent evolution with placental lactogens emerging separately in the ruminant, rodent, and primate lineages and chorionic gonadotropins evolving separately in equids and higher primates. Finally, coevolution in the primate lineage of killer immunoglobulin-like receptors and human leukocyte antigens can be linked to the deep invasion of the uterus by trophoblast that is a characteristic feature of human placentation. © 2012 the American Physiological Society.

Loading University of Southern Denmark collaborators
Loading University of Southern Denmark collaborators