Los Angeles, CA, United States

University of Southern California

Los Angeles, CA, United States

The University of Southern California is a private, not-for-profit, nonsectarian, research university founded in 1880 with its main campus in the city area of Los Angeles, California. As California's oldest private research university, USC has historically educated a large number of the region's business leaders and professionals. In recent decades, the university has also leveraged its location in Los Angeles to establish relationships with research and cultural institutions throughout Asia and the Pacific Rim. In 2011, USC was named among the Top 10 Dream Colleges in the nation. It holds a vast array of trademarks and wordmarks to the term "USC."For the 2012-2013 academic year, there were 18,316 students enrolled in four-year undergraduate programs. USC is also home to 21,642 graduate and professional students in a number of different programs, including business, law, social work, and medicine. The university has a "very high" level of research activity and received $560.9 million in sponsored research from 2009 to 2010. USC sponsors a variety of intercollegiate sports and competes in the National Collegiate Athletic Association as a member of the Pacific-12 Conference. Members of the sports teams, the Trojans, have won 100 NCAA team championships, ranking them third in the nation, and 378 NCAA individual championships, ranking them second in the nation. Trojan athletes have won 287 medals at the Olympic games , more than any other university in the world. If USC were a country, it would rank 12th in most Olympic gold medals. Wikipedia.

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University of Southern California and Reolab Inc. | Date: 2017-04-19

A module may be provided with at least one opening, the opening being an endpoint of a microfluidic channel that passes through at least part of the module. A set of multiple such modules may be arranged into an arrangement of modules, which may be coupled together using one or more coupling mechanisms included on each module. The arrangement of modules may fit within a regular polyhedral grid, and each module within the arrangement of modules may have a form suitable for arrangement of the modules within the regular polyhedral grid. Fluid may then flow through at least a subset of the arrangement of modules via the microfluidic channel of each module of the subset of the arrangement of modules. Some modules may include sensors, actuators, or inner microfluidic channel surface coatings. The arrangement of modules may form a microfluidic circuit that can perform a microfluidic circuit function.

University of Southern California | Date: 2017-02-24

A method includes combining a coating material and an uncoated particulate core material in a solution having a selected ionic strength. The selected ionic strength promotes coating of the uncoated particulate core material with the coating material to form coated particles; and the coated particles can be collected after formation. The coating material has a higher electrical conductivity than the core material.

University of Southern California | Date: 2017-02-17

Benzolipoxin analogs, methods of their preparation and pharmaceutical compositions containing the compounds are provided. The compounds and compositions are useful in methods for treatment of various diseases, including, inflammation, autoimmune disease and abnormal cell proliferation.

University of Southern California | Date: 2017-06-14

This disclosure relates to apoptotic bodies. The disclosure particularly relates to a composition comprising the apoptotic bodies. The disclosure further relates to preparation of apoptotic bodies from stem cells. The disclosure also relates to medical treatments comprising the use of the composition comprising the apoptotic bodies. The apoptotic bodies may comprise apoptotic stem cells. The apoptosis of a cell may be induced by a starvation method, an ultra-violet irradiation method, a thermal stress method, a staurosporine method, or a combination thereof.

Medical College of Wisconsin and University of Southern California | Date: 2017-06-21

A swallow exerciser device that exercises and thereby strengthens the muscles involved in swallowing includes a rigid shell, an adjustable fastener, and an inflatable pad. The rigid shell has a longitudinal dimension such that the shell extends above and below the larynx of the subject when the swallow exerciser device is positioned over the larynx of the subject. The adjustable fastener is dimensioned to secure the shell around a neck of the subject with the shell positioned over the larynx of the subject. The inflatable pad is connected to a proximal surface of the shell. The inflatable pad is dimensioned to apply resistance to force of at least one swallowing muscle of the subject when the shell positioned over the larynx of the subject and when the inflatable pad is in an inflated position. The swallow exerciser device can be used in a method for improving swallowing function in a subject.

Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.

University of Southern California | Date: 2017-06-07

Medical instruments, particularly structurally-adjustable speculums and retractors for obstetrical and gynecological operations, procedures, and examinations, including a minimally obstructive compact speculum or retractor. The compact speculum may comprise a first wing and a second wing; and a hinge comprising at least one hinge component. The compact speculum may further comprise a ratchet that releasably holds the wings in an open position. The hinge component may comprise the ratchet, an illumination source, a fluid handler, a light guide, a lubrication source, or a combination thereof. The compact speculum may be a vaginal speculum.

Lieber M.R.,University of Southern California
Annual Review of Biochemistry | Year: 2010

Double-strand DNA breaks are common events in eukaryotic cells, and there are two major pathways for repairing them: homologous recombination (HR) and nonhomologous DNA end joining (NHEJ). The various causes of double-strand breaks (DSBs) result in a diverse chemistry of DNA ends that must be repaired. Across NHEJ evolution, the enzymes of the NHEJ pathway exhibit a remarkable degree of structural tolerance in the range of DNA end substrate configurations upon which they can act. In vertebrate cells, the nuclease, DNA polymerases, and ligase of NHEJ are the most mechanistically flexible and multifunctional enzymes in each of their classes. Unlike repair pathways for more defined lesions, NHEJ repair enzymes act iteratively, act in any order, and can function independently of one another at each of the two DNA ends being joined. NHEJ is critical not only for the repair of pathologic DSBs as in chromosomal translocations, but also for the repair of physiologic DSBs created during variable (diversity) joining [V(D)J] recombination and class switch recombination (CSR). Therefore, patients lacking normal NHEJ are not only sensitive to ionizing radiation (IR), but also severely immunodeficient. © 2010 by Annual Reviews. All rights reserved.

Jones P.A.,University of Southern California
Nature Reviews Genetics | Year: 2012

DNA methylation is frequently described as a 'silencing' epigenetic mark, and indeed this function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved genome-scale mapping of methylation, we can evaluate DNA methylation in different genomic contexts: transcriptional start sites with or without CpG islands, in gene bodies, at regulatory elements and at repeat sequences. The emerging picture is that the function of DNA methylation seems to vary with context, and the relationship between DNA methylation and transcription is more nuanced than we realized at first. Improving our understanding of the functions of DNA methylation is necessary for interpreting changes in this mark that are observed in diseases such as cancer. © 2012 Macmillan Publishers Limited. All rights reserved.

Lee A.S.,University of Southern California
Nature Reviews Cancer | Year: 2014

The glucose-regulated proteins (GRPs) are stress-inducible chaperones that mostly reside in the endoplasmic reticulum or the mitochondria. Recent advances show that the GRPs have functions that are distinct from those of the related heat shock proteins, and they can be actively translocated to other cellular locations and assume novel functions that control signalling, proliferation, invasion, apoptosis, inflammation and immunity. Mouse models further identified their specific roles in development, tumorigenesis, metastasis and angiogenesis. This Review describes their discovery and regulation, as well as their biological functions in cancer. Promising agents that use or target the GRPs are being developed, and their efficacy as anticancer therapeutics is also discussed. © 2014 Macmillan Publishers Limited. All rights reserved.

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