Petronilho F.,University of South Santa Catarina
Inflammation & allergy drug targets | Year: 2013
Gastrin-releasing peptide (GRP) is a neuropeptide that acts through G protein coupled receptors and is involved in signal transmission in both the central and peripheral nervous systems. Its receptor, gastrin-releasing peptide receptor (GRPR), is expressed by various cell types, and it is overexpressed in cancer cells. In recent years, studies have suggested the relationship of GRP and inflammatory diseases. RC-3095, a selective GRPR antagonist, was found to have antiinflammatory properties in models of arthritis, gastritis, uveitis and sepsis. Furthermore, GRP mediates air pollutioninduced airway hyperreactivity and airway inflammation in mice. In conclusion, GRP and its receptor are relevant to the inflammatory response, being a potential therapeutic target several diseases are related to inflammation.
Maraschin J.F.,University of South Santa Catarina
Advances in experimental medicine and biology | Year: 2012
Diabetes mellitus (DM) represents a heterogeneous group of conditions that share certain characteristics with hyperglycemia as a common feature. The first worldwide accepted classification scheme for DM was published in 1979 by the National Diabetes Data Group (NDDG) and classified DM based on the pharmacologic therapy applied into two major groups: Insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM). The terms coined by the NDDG became popular during the 1980s and 1990s, but with time, the misclassification of patients became evident. Since the correct classification of DM allows a more adequate treatment, the new classification proposed by the American Diabetes Association in 1997 was based in the pathogenesis of the disease and comprises four categories: Type 1 DM, Type 2 DM, other types and gestational diabetes. Despite significant advances in diabetes understanding, some gray areas still remain and new studies are necessary to further improve diabetes classification.
Traebert J.,University of South Santa Catarina
Oral health & preventive dentistry | Year: 2011
To assess the prevalence and severity of dental caries among 12-year-old schoolchildren and to examine its possible association with maternal schooling. A cross-sectional study involving a representative sample (n = 253) of the 12-year-old schoolchildren enrolled in 14 schools of the municipality of Curitibanos, Brazil was carried out in 2006. Clinical information was obtained through the World Health Organization criteria. Non-clinical data were obtained through interviews with schoolchildren. Associations were analysed using chi-square test or Fisher exact test followed by non-conditional multiple logistic regression analysis to test the independence of associations between outcome and explanatory variables. P-values were set at < 0.05. The prevalence of caries was 81.7% and the mean decayed, missing or filled teeth score was 4.08. Prevalence was significantly higher among girls, with a prevalence ratio of 2.58 (95% CI 1.25, 5.32) (P = 0.010); among schoolchildren from mothers with lower education level, with a prevalence ratio of 3.26 (95% CI 1.32, 8.06) (P = 0.010); and among schoolchildren who had ever visited a dentist, with a prevalence ratio of 2.91 (95% CI 1.14, 7.62) (P = 0.030). The prevalence and severity of caries were higher than the Brazilian national average. The prevalence was statistically associated with maternal schooling, had visited a dentist, and gender.
Bertelli J.A.,University of South Santa Catarina
Journal of Hand Surgery | Year: 2015
Purpose To report our experiences reconstructing thumb and finger flexion in patients with extensive palsy of the upper limb by transferring the radial nerve branch to the extensor carpi radialis brevis (ECRB) to the anterior interosseous nerve (AIN). Methods Within 8 months after injury, 4 patients with either a combined high median/ulnar nerve palsy or C7-T1 brachial plexus root avulsion underwent surgical reconstruction for thumb and finger flexion. As part of the reconstructive procedure, the branch of the radial nerve to the ECRB was transferred to the AIN. Results At final evaluation, which averaged 13 months postoperatively, all patients had recovered full finger and thumb flexion, scoring M4 per Medical Research Council guidelines. Average grasp strength was 5 kg, and pinch strength was 2 kg. Even in anesthetic fingers and with their eyes closed, patients could correctly identify passive extension of their distal interphalangeal joints. Wrist extension was preserved in all patients. Conclusions In 4 patients, transfer of the branch of the radial nerve to the ECRB to the AIN predictably reconstructed thumb and finger flexion. Finger flexion also recovered in those fingers in which the flexor digitorum profundus was primarily innervated by the ulnar nerve. Despite extended sensory deficits, patients ultimately were able to use their hands regularly in daily life. Type of study/level of evidence Therapeutic III. © 2015 American Society for Surgery of the Hand.
Bertelli J.A.,University of South Santa Catarina
The Journal of hand surgery, European volume | Year: 2013
Stretch injuries of the C5-C7 roots of the brachial plexus traditionally have been associated with palsies of shoulder abduction/external rotation, elbow flexion/extension, and wrist, thumb, and finger extension. Based on current myotome maps we hypothesized that, as far as motion is concerned, palsies involving C5-C6 and C5-C7 root injuries should be similar. In 38 patients with upper-type palsies of the brachial plexus, we examined for correlations between clinical findings and root injury level, as documented by CT tomomyeloscan. Contrary to commonly held beliefs, C5-C7 root injuries were not associated with loss of extension of the elbow, wrist, thumb, or fingers, but residual hand strength was much lower with C5-C7 vs C5-C6 lesions.